CN104491689A - Ionization radiation injury protective agent - Google Patents

Ionization radiation injury protective agent Download PDF

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Publication number
CN104491689A
CN104491689A CN201410716826.8A CN201410716826A CN104491689A CN 104491689 A CN104491689 A CN 104491689A CN 201410716826 A CN201410716826 A CN 201410716826A CN 104491689 A CN104491689 A CN 104491689A
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China
Prior art keywords
parts
protective agent
radiation injury
herba
ionization radiation
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Pending
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CN201410716826.8A
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Chinese (zh)
Inventor
魏若琳
刘幸幸
梁志超
刘学昊
常俊军
曲若纹
王彬彬
孙瀚之
李娜
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JUNAN POWER SUPPLY CO Ltd
State Grid Corp of China SGCC
Linyi Power Supply Co of State Grid Shandong Electric Power Co Ltd
Original Assignee
JUNAN POWER SUPPLY CO Ltd
State Grid Corp of China SGCC
Linyi Power Supply Co of State Grid Shandong Electric Power Co Ltd
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Priority to CN201410716826.8A priority Critical patent/CN104491689A/en
Publication of CN104491689A publication Critical patent/CN104491689A/en
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Abstract

The invention relates to an ionization radiation injury protective agent. The ionization radiation injury protective agent is prepared from the following raw materials: jasminum cinnamomifolium, houttuynia cordata, polygonatum odoratum, fructus lycii, cortex phellodendri, ginkgo leaves, perilla leaves, duckweed, loquat leaves, glossy privet fruits, curcuma aromatica and the like. The ionization radiation injury protective agent is convenient to use, has a radiation protection effect and also has an auxiliary radiation injury treatment effect, the adopted raw materials are traditional Chinese medicinal materials common in China and are widely distributed, the cost is low, and low cost is one of the advantages of the ionization radiation injury protective agent in future development and application, so that the ionization radiation injury protective agent has broad application prospects.

Description

A kind of ionization radiation injury protective agent
Technical field
The invention belongs to Traditional Chinese medicine healthcare drug technical field, particularly, relate to a kind of containing Chinese medicinal components for ionization radiation injury protective agent.
Background technology
Along with the development of science and technology, ionizing radiation has penetrated into the many fields in human being's production life, inevitably cause radiation damage to people, as the space radiation etc. that radioactivity damages and in space travel, personnel are subject to of occupational irradiation personnel, work of electric power system personnel are due to job specification, face more radiation in various degree, and science shows that these ionizing radiation affect the healthy of staff invariably, it can bring out cancer and accelerate the cancer cell multiplication of human body.Electromagnetic radiation pollution can affect the blood circulation of human body, immunity, reproduction and metabolic function, serious also can bring out cancer, and the cancer cell multiplication of human body can be accelerated, the electromagnetic radiation of high dose also can affect and destroy the original bioelectric current of human body and biological magnetic field, original electromagnetic field in human body is occurred abnormal.
Radioprotectant refers to that body or a certain biosystem are subject to before and after ionization radiation irradiation, and give certain substance in early days and alleviate its radiation damage, promote that it recovers, the compound with this effect is called radioprotectant.Modern main radioprotectant has: thioctic acid analog derivative, estrogens, calcium ion antagonist, bacterial toxins, cytokine, polysaccharide and Chinese medicine etc.Although found the compound of some effectively pre-antisitic defects, because mostly being sulphur-containing substance, toxicity is comparatively large, is applied directly to clinical probability less.Natural drug becomes rapidly the new focus of radioprotector research with little, the resourceful advantage of its toxic and side effects.The traditional Chinese medical science thinks that many symptoms that acute radiation sickness their early stage shows are that excessive noxious heat causes, and antipyretic and antidotal type medicine has the effects such as antibacterial, antiviral, and can the immunologic function of enhancing body, also has Study On The Radioprotective.In fact, carry out research to some Chinese herbal medicine and the active component that is separated to from Chinese herbal medicine to find, there is heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, the Chinese medicinal formulae of blood yiqi and single medicinal material and all have radiation resistance in various degree, at present, the research of Traditional Chinese Medicine Anti radiation aspect mainly rests in the aspect of single rich in nutrition medicine, but Chinese medicine compound is used for radioprotector report seldom.So it is little that people expect to develop toxicity, can be used for the product of clinical prevention.Therefore developing anti-radiation product, is developing direction main at present.
Summary of the invention
The object of this invention is to provide a kind ofly to have no side effect, safe ready, cheap ionization radiation injury protective agent, overcome prior art protective agent sulfur-bearing, toxicity is larger waits related defects, and effective solution accepts the problem such as hypoimmunity, hemopoietic function damage that radiation causes for a long time.
Present inventor is according to forefathers' experience and oneself medical practice for many years, by the research to Chinese medicine, and in conjunction with dialectical demonstration, in many ways collect the length of many families, seek therapeutic regimen, from motherland's medical treasure-house, filter out the natural Chinese medicine of benefiting QI and nourishing blood, liver and kidney tonifying, clearing away heat and promoting production of body fluid effect, by theory of Chinese medical science prescription, improve hemopoietic function damage that chronic exposure causes, improve immunity aspect, curative effect certainly, is the innovation on radiopharmaceutical.
For achieving the above object, the technical solution used in the present invention is as follows:
A kind of ionization radiation injury protective agent, is characterized in that, is prepared and obtain by following weight proportioning raw material,
30 parts, spun gold rattan, Herba Houttuyniae 30 parts, Rhizoma Polygonati Odorati 30 parts, Fructus Lycii 28 parts, Cortex Phellodendri 28 parts,
Folium Ginkgo 28 parts, Folium Perillae 28 parts, 25 parts, Herba Spirodelae, Folium Eriobotryae 25 parts, Fructus Ligustri Lucidi 25 parts,
Radix Curcumae 20 parts, Myrrha 20 parts, Olibanum 20 parts, Semen Cassiae 20 parts, Flos Lonicerae 18 parts,
Radix Salviae Miltiorrhizae 18 parts, Herba Portulacae 18 parts, Herba Bidentis Bipinnatae 15 parts, Semen Coicis 15 parts, Herba Hedyotidis Diffusae 15 parts,
10 parts, Radix Glycyrrhizae, Fructus Schisandrae Chinensis 10 parts, Fructus Crataegi 10 parts, Spina Gleditsiae 7 parts, Herba Schizonepetae 5 parts,
Be prepared from by the following method:
Get Herba Houttuyniae 30 parts, Rhizoma Polygonati Odorati 30 parts, Fructus Lycii 28 parts, Cortex Phellodendri 28 parts, Folium Ginkgo 28 parts, Myrrha 20 parts, Olibanum 20 parts, Semen Coicis 15 parts, Herba Hedyotidis Diffusae 15 parts, 10 parts, Radix Glycyrrhizae, Fructus Schisandrae Chinensis 10 parts, add 70% soak with ethanol 2 hours; reflux, extract, twice; each 1 hour; merge extractive liquid; filter; be condensed into the extractum that relative density is 1.2g/ml, crushed after being dried obtains A;
Get residual components and decoct extraction 2 times, first time extracts the water adding 5 times of weight, and extraction time is 0.5 hour; Second time extracts the water adding 3 times of weight, and extraction time is 0.5 hour; Filter, merging filtrate, be concentrated into the thick paste that density is 1.2g/ml, crushed after being dried obtains complex B;
Mixed complex A and complex B obtain the application for ionization radiation injury protective agent.
Usage and dosage: oral, each 0.2g, every day three times five days is a course for the treatment of.
The present invention is based on the differential diagnosis of diseases of motherland's medical science and the dialectical principle combined, treating both the principal and secondary aspects of a disease, deficiency and excess is also controlled, inside and outside logical tune, its Effective Component of Chinese Medicine all adopts natural raw material of Chinese medicine, its preparation is easy, medicine source is extensive, with low cost, it follows the prescriptions principle of the traditional Chinese medical science, reliably evident in efficacy through clinical practice, mild in medicine property and, there is not toxic and side effects, drug use is convenient, the existing Study On The Radioprotective of medicine, also the effect of auxiliary radiation injury in treating is had, raw materials used is China's common Chinese medicine material, widely distributed, cheap, it is one of advantage of its following input Application and Development, have a extensive future.
Detailed description of the invention
Below in conjunction with specific embodiment, set forth the present invention further.These embodiments are only not used in for illustration of the present invention and limit the scope of the invention.The experimental technique of unreceipted actual conditions in the following example, the usually conveniently conditioned disjunction condition of advising according to manufacturer.Unless otherwise defined, all specialties used in literary composition and scientific words and one skilled in the art the same meaning be familiar with.In addition, any method similar or impartial to described content and material all can be applicable in the inventive method.The use that better implementation method described in literary composition and material only present a demonstration.
Embodiment 1
A kind of ionization radiation injury protective agent, is characterized in that, is prepared and obtain by following weight proportioning raw material,
30 parts, spun gold rattan, Herba Houttuyniae 30 parts, Rhizoma Polygonati Odorati 30 parts, Fructus Lycii 28 parts, Cortex Phellodendri 28 parts,
Folium Ginkgo 28 parts, Folium Perillae 28 parts, 25 parts, Herba Spirodelae, Folium Eriobotryae 25 parts, Fructus Ligustri Lucidi 25 parts,
Radix Curcumae 20 parts, Myrrha 20 parts, Olibanum 20 parts, Semen Cassiae 20 parts, Flos Lonicerae 18 parts,
Radix Salviae Miltiorrhizae 18 parts, Herba Portulacae 18 parts, Herba Bidentis Bipinnatae 15 parts, Semen Coicis 15 parts, Herba Hedyotidis Diffusae 15 parts,
10 parts, Radix Glycyrrhizae, Fructus Schisandrae Chinensis 10 parts, Fructus Crataegi 10 parts, Spina Gleditsiae 7 parts, Herba Schizonepetae 5 parts,
Be prepared from by the following method:
Get Herba Houttuyniae 30 parts, Rhizoma Polygonati Odorati 30 parts, Fructus Lycii 28 parts, Cortex Phellodendri 28 parts, Folium Ginkgo 28 parts, Myrrha 20 parts, Olibanum 20 parts, Semen Coicis 15 parts, Herba Hedyotidis Diffusae 15 parts, 10 parts, Radix Glycyrrhizae, Fructus Schisandrae Chinensis 10 parts, add 70% soak with ethanol 2 hours; reflux, extract, twice; each 1 hour; merge extractive liquid; filter; be condensed into the extractum that relative density is 1.2g/ml, crushed after being dried obtains complex A;
Get residual components and decoct extraction 2 times, first time extracts the water adding 5 times of weight, and extraction time is 0.5 hour; Second time extracts the water adding 3 times of weight, and extraction time is 0.5 hour; Filter, merging filtrate, be concentrated into the thick paste that density is 1.2g/ml, crushed after being dried obtains complex B;
Mixed complex A and complex B obtain the application for ionization radiation injury protective agent.
Usage and dosage: oral, each 0.2g, every day three times five days is a course for the treatment of.
 
Embodiment 2
Hemopoietic tissue is to ionizing radiation very sensitive organization, and the radiation damage of hemopoietic system and the hematopoietic disorder brought thus are the key pathogenetic links of acute radiation sickness pathological change.Therefore, protection hemopoietic tissue is from radiation damage or alleviate degree of injury, is one of important research direction of radiation damage prevention and control field all the time.After hematopoietic cell raying damage, therefore the quantity of leucocyte be reflected in peripheral blood routine acutely declines, and this experimental selection peripheral hemogram is functional verification index.
Experimental technique
Select healthy SPF level Kunming mouse, male, 60, be divided into 3 groups at random by body weight, often organize 20, that is: normal group, irradiation control group, embodiment 1 preparation group.Successive administration 14 days.
The foundation of model:
In administration the 7th day, except normal group, all the other are respectively organized mice and all adopt the irradiation of 60Co γ-source to set up Radiation damage models.During irradiation, mice puts special mouse cage restraint, carries out whole body single uniform irradiation under waking state.Radioactive source is 60Co γ-source, exposure dose rate 1.0Gy/min, and accumulative exposure dose is 6.5Gy.
Testing index:
Continue empirically design administration after irradiation, and in latter 3rd day, 7 days of irradiation, eye socket got blood, adds in EDTA-2Na anticoagulant tube, detects erythrocyte by blood-counter system, leukocyte, platelet.
After irradiation the 3rd day
Result is as shown in table 1, compares with normal group, has significant difference (P<0.01).Prompting, modeling success.Compare with irradiation control group, the RBC of normal group and embodiment group, WBC recover all there is significant difference (P<0.01).
Table 1 irradiates latter 3 days mice indexs
Group RBC(10 12Individual/L) WBC(10 9Individual/L) HGB(g/L)
Normal group 10.39±1.03 7.35±0.58 152.37±3.21
Irradiation control group 5.27±0.89 2.02±0.63 103.41±3.51
Experimental group (embodiment 1 group) 10.15±1.07 6.51±0.47 141.29±4.13
Table 2 irradiates latter 7 days mice indexs
Group RBC(10 12Individual/L) WBC(10 9Individual/L) HGB(g/L)
Normal group 10.13±1.25 7.28±0.45 152.29±3.03
Irradiation control group 3.25±0.93 1.53±0.45 83.43±4.38
Experimental group (embodiment 1 group) 9.51±1.03 6.31±0.38 139.71±3.59
Above-mentioned experimentation display, in peripheral hemogram, preparation prepared by the present invention has protective action to radiation damage.
 
Embodiment 3
Radiation murine bonemarrow nucleated cells number and mice spleen weigh, the impact of spleen index
Spleen is maximum lymphatic organ, is also one of important peripheral immune organ, containing a large amount of T cell, natural killer cell and Tumor-infiltrating lymphocytes etc.Spleen is also place haematogenous antigen being produced to immunne response, can synthesize and secrete as the bioactive substance such as complement, IFN, and spleen weight and index and spleen index reflect the immune state of body indirectly.
SPF level Kunming mouse, 6-8 week age, male, Mouse Weight is 18-22g, 60.
Animal grouping and method
Experiment is divided into normal group, irradiation control group, the embodiment of the present invention 1 medicine group, often organizes 20.The disposable total irradiation of 60Co gamma-rays, close rate 3.2 seconds/cGy, irradiation field 25cm × 25cm, source-skin distance 80cm, exposure dose 6Gy.60Co γ respectively at experiment first day and the tenth day with same dose irradiation.After irradiation, mice is total to gastric infusion 20 days.Matched group is with 0.2ml normal saline gavage.Test the 20th day, detect each experimental index, terminate experiment.
Testing index
Frangments smear
Get side femur, clean with normal saline flushing, cut off two ends epiphysis, with No. 7 needle pierces femur ends, repeatedly rinse medullary cavity with PBS liquid, till femur punching is for white.The bone marrow fluid gone out filters stand-by by No. 4 syringe needles.Get 0.5ml 4% acetic acid and 0.5ml bone marrow fluid to be placed in another test tube and to mix, place 2 minutes, again fully mix, then get and instill counting chamber a little, count nucleated cell under the microscope.Number of nucleated cells (L)=4 block plaid nucleated cell sum/4 × 10 4× extension rate
Thymus and spleen weight
Spleen is got in experiment end, and analytical balance is weighed.Spleen index=spleen weight/body weight × 1000
After the result embodiment of the present invention as shown in table 31 group significantly increases and irradiates, the spleen of mice weighs and spleen index, compares, have obvious statistical significance with irradiation control group
Table 3 irradiation is on bone marrow nucleated cell and mice spleen is heavy, spleen index impact
Group Bone marrow nucleated cell (× 10 5Individual/root) Spleen heavy (g) Spleen index
Normal group 90.21±12.37 0.1377±0.0261 4.61±0.31
Irradiation control group 50.15±9.38 0.0827±0.0145 3.21±0.28
Experimental group (embodiment 1 group) 75.53±13.04 0.1154±0.0285 4.17±0.42
Embodiment 4
High certain, man, 37 years old, during because of ultrasonic therapeutic, misoperation, occurred afterwards feeling sick, and lassitude, was off one's feed and waits symptom, after taking four courses for the treatment of of Chinese medicine preparation of the present invention, transference cure.
Woods master worker, due to working principle, there is the symptoms such as skin is dark yellow, lassitude in transformer station operating personnel, even uncomfortable in chest, the symptom such as to feel sick, through diagnosis, after taking three courses for the treatment of of invention formulation, transference cure, and without recurrence.
What more than enumerate is only best specific embodiment of the present invention.Obviously, the invention is not restricted to above embodiment, all minor variations that those of ordinary skill in the art can directly derive from content disclosed by the invention or associate, all should protection scope of the present invention be thought.

Claims (2)

1. an ionization radiation injury protective agent, is characterized in that, described protective agent is prepared by following weight parts raw material and obtains,
30 parts, spun gold rattan, Herba Houttuyniae 30 parts, Rhizoma Polygonati Odorati 30 parts, Fructus Lycii 28 parts, Cortex Phellodendri 28 parts,
Folium Ginkgo 28 parts, Folium Perillae 28 parts, 25 parts, Herba Spirodelae, Folium Eriobotryae 25 parts, Fructus Ligustri Lucidi 25 parts,
Radix Curcumae 20 parts, Myrrha 20 parts, Olibanum 20 parts, Semen Cassiae 20 parts, Flos Lonicerae 18 parts,
Radix Salviae Miltiorrhizae 18 parts, Herba Portulacae 18 parts, Herba Bidentis Bipinnatae 15 parts, Semen Coicis 15 parts, Herba Hedyotidis Diffusae 15 parts,
10 parts, Radix Glycyrrhizae, Fructus Schisandrae Chinensis 10 parts, Fructus Crataegi 10 parts, Spina Gleditsiae 7 parts, Herba Schizonepetae 5 parts.
2. ionization radiation injury protective agent according to claim 1, is characterized in that, described protective agent is prepared from by the following method:
(1) each raw material is got according to parts by weight;
(2) Herba Houttuyniae, Rhizoma Polygonati Odorati, Fructus Lycii, Cortex Phellodendri, Folium Ginkgo, Myrrha, Olibanum, Semen Coicis, Herba Hedyotidis Diffusae, Radix Glycyrrhizae and Fructus Schisandrae Chinensis is got, add 70% soak with ethanol 2 hours, reflux, extract, twice, each 1 hour, merge extractive liquid, filter, be condensed into the extractum that density is 1.2g/ml, crushed after being dried obtains complex A;
(3) get residual components, decoct extraction 2 times, first time extracts the water adding 5 times of weight, and decocting time is 0.5 hour; Second time extracts the water adding 3 times of weight, and decocting time is 0.5 hour; Filter, merging filtrate, be concentrated into the thick paste that density is 1.2g/ml, crushed after being dried obtains complex B;
(4) by complex A and complex B mix homogeneously, to obtain final product.
CN201410716826.8A 2014-12-02 2014-12-02 Ionization radiation injury protective agent Pending CN104491689A (en)

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CN105412809A (en) * 2015-10-25 2016-03-23 国网山东临沭县供电公司 Protection product used for electric power operation
CN105435092A (en) * 2015-10-25 2016-03-30 国网山东蒙阴县供电公司 Protection product for electric power outdoor operation and application thereof
CN105497774A (en) * 2015-10-25 2016-04-20 国网山东省电力公司临沂供电公司 Transformer substation electromagnetic radiation prevention preparation and preparation technology thereof
CN105998807A (en) * 2016-06-28 2016-10-12 牡丹江医学院 Traditional Chinese medicine composition capable of invigorating health and resisting radiation and preparing method thereof

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CN103735863A (en) * 2014-01-16 2014-04-23 河南中医学院 Traditional Chinese medicine composition for preventing and controlling radiation

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Publication number Priority date Publication date Assignee Title
CN1486709A (en) * 2002-12-31 2004-04-07 张立中 Health care Chinese medicine for computer worker and TV watcher
CN101069559A (en) * 2006-05-12 2007-11-14 赵海洲 Ganoderma-lucidum grain lotus-seed-heart powder
CN103735863A (en) * 2014-01-16 2014-04-23 河南中医学院 Traditional Chinese medicine composition for preventing and controlling radiation

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CN105412809A (en) * 2015-10-25 2016-03-23 国网山东临沭县供电公司 Protection product used for electric power operation
CN105435092A (en) * 2015-10-25 2016-03-30 国网山东蒙阴县供电公司 Protection product for electric power outdoor operation and application thereof
CN105497774A (en) * 2015-10-25 2016-04-20 国网山东省电力公司临沂供电公司 Transformer substation electromagnetic radiation prevention preparation and preparation technology thereof
CN105998807A (en) * 2016-06-28 2016-10-12 牡丹江医学院 Traditional Chinese medicine composition capable of invigorating health and resisting radiation and preparing method thereof
CN105998807B (en) * 2016-06-28 2019-11-26 牡丹江医学院 It builds up health anti-radiation Chinese medicine composition and preparation method

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