CN103735863B - A kind of Chinese medicine composition of preventing and treating radiation - Google Patents
A kind of Chinese medicine composition of preventing and treating radiation Download PDFInfo
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- CN103735863B CN103735863B CN201410022608.4A CN201410022608A CN103735863B CN 103735863 B CN103735863 B CN 103735863B CN 201410022608 A CN201410022608 A CN 201410022608A CN 103735863 B CN103735863 B CN 103735863B
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Abstract
The present invention relates to prevent and treat the Chinese medicine composition of radiation, can effectively solve and accept for a long time the hypoimmunity that radiation causes, the problem of hematopoiesis function damage, the technical scheme of its solution is, this Chinese medicine composition is the material medicine by following weighing scale: radix pseudostellariae 10-30g, Psoralea corylifolia 5-15g, fruit of Chinese wolfberry 10-30g, stem of noble dendrobium 5-30g, radix polygonati officinalis 10-20g, cordate houttuynia 10-30g, wolf's milk 10-30g, Han dish 10-30g, pseudo-ginseng 3-10g, reticulate millettia 10-30g and madder 5-15g make, wherein, above-mentioned raw materials medicine is mixed, with distilled water immersion 1 hour, add the ethanol that the water of material medicine 4-6 times weight or the volumetric concentration of 4-6 times of weight are 70% at every turn, decoct 2 times, each 70 minutes, merge 2 times decoction liquor, filter, the liquid extract that while being concentrated into 60 DEG C, relative density is 1.16, obtain, the hematopoiesis function damage that the present invention causes in the long-term radiation of improvement, improve immunity aspect, curative effect certainly, it is the innovation on radiopharmaceutical.
Description
Technical field
The present invention relates to medicine, particularly a kind of Chinese medicine composition of preventing and treating radiation.
Background technology
Along with developing rapidly that nuclear technology is applied at aspects such as industry, medical science, life sciences, the chance that people contact with radioactive rayIncreasing, such as the extensive use of computer, mobile phone, TV, micro-wave oven etc., radiation is not affecting ours all the timeModern day life. At medical domain, radiodiagnosis and treatment are also widely used. Especially clinical tumor patient is putTreat the conventional means that has become oncotherapy. These have all increased the probability that medical personnel contact with radioactive ray.
Accept for a long time the damage that radiation can cause a lot of organs and systems, accepting in a large number radiation even can induced tumor, makeBecome early ageing. The modal toxicity of radiotherapy and destroy hemopoietic system, reduce function of immune system. Due to some known toolsThere is the chemicals toxicity of radiation resistance larger, therefore study the radiopharmaceutical that toxic and side effect is little and seem very important. Therefore,The improvement of radiopharmaceutical is the problem of needing at present solution badly.
Summary of the invention
For above-mentioned situation, for solving the defect of prior art, the present invention's object is just to provide a kind of Chinese drug-treated group of preventing and treating radiationCompound, can effectively solve the hypoimmunity of accepting for a long time radiation and causing, the problem of hematopoiesis function damage.
The technical scheme that the present invention solves is that this Chinese medicine composition is the material medicine by following weighing scale: radix pseudostellariae 10-30g,Psoralea corylifolia 5-15g, fruit of Chinese wolfberry 10-30g, stem of noble dendrobium 5-30g, radix polygonati officinalis 10-20g, cordate houttuynia 10-30g, wolf's milk 10-30g,Han dish 10-30g, pseudo-ginseng 3-10g, reticulate millettia 10-30g and madder 5-15g make, and wherein, above-mentioned raw materials medicine are blended inTogether, use distilled water immersion 1 hour adds the water of material medicine 4-6 times weight at every turn or the volumetric concentration of 4-6 times of weight is 70%Ethanol, decoct 2 times, each 70 minutes, merge 2 times decoction liquor, filter, while being concentrated into 60 DEG C, relative density is 1.16Liquid extract, to obtain final product.
Adopt conventional preparation technology, Chinese medicine composition of the present invention the tablet of auxiliary oncotherapy, granule, capsule, pill,Application in oral liquid, any medicine of syrup.
The present invention, tonifying the liver and kidney, on nourishing qi and blood medicine radix pseudostellariae, Psoralea corylifolia, the fruit of Chinese wolfberry, reticulate millettia basis, adds heat-clearing rawTianjin, promoting blood circulation Chinese Medicinal Houttuynia Cordata Thunb, wolf's milk, Han dish, the stem of noble dendrobium, radix polygonati officinalis, pseudo-ginseng, reticulate millettia and madder, improving for a long timeHematopoiesis function damage, raising immunity aspect that radiation causes, curative effect is sure, is the innovation on radiopharmaceutical.
Detailed description of the invention
Below in conjunction with embodiment, the specific embodiment of the present invention is described in further detail.
Embodiment 1
This Chinese medicine composition is the material medicine by following weighing scale: radix pseudostellariae 10g, Psoralea corylifolia 5g, fruit of Chinese wolfberry 10g, the stem of noble dendrobium5g, radix polygonati officinalis 10g, cordate houttuynia 10g, wolf's milk 10g, Han dish 10g, pseudo-ginseng 3g, reticulate millettia 10g and madder 5g make,Wherein, above-mentioned raw materials medicine is mixed, uses distilled water immersion 1 hour, add the water of 4 times of weight of material medicine at every turn,Decoct 2 times, each 70 minutes, merge 2 times decoction liquor, filter, the liquid extract that while being concentrated into 60 DEG C, relative density is 1.16,Obtain.
Embodiment 2
This Chinese medicine composition is the material medicine by following weighing scale: radix pseudostellariae 20g, Psoralea corylifolia 10g, fruit of Chinese wolfberry 20g, the stem of noble dendrobium18g, radix polygonati officinalis 15g, cordate houttuynia 20g, wolf's milk 20g, Han dish 20g, pseudo-ginseng 6g, reticulate millettia 20g and madder 10g make,Wherein, above-mentioned raw materials medicine is mixed, use distilled water immersion 1 hour, add the volume of 5 times of weight of material medicine at every turnConcentration is 70% ethanol, decocts 2 times, and each 70 minutes, merge 2 times decoction liquor, filter, relatively close while being concentrated into 60 DEG CDegree is 1.16 liquid extract, to obtain final product.
Embodiment 3
This Chinese medicine composition is the material medicine by following weighing scale: radix pseudostellariae 30g, Psoralea corylifolia 15g, fruit of Chinese wolfberry 30g, the stem of noble dendrobium30g, radix polygonati officinalis 20g, cordate houttuynia 30g, wolf's milk 30g, Han dish 30g, pseudo-ginseng 10g, reticulate millettia 30g and madder 15g make,Wherein, above-mentioned raw materials medicine is mixed, uses distilled water immersion 1 hour, add the water of 6 times of weight of material medicine at every turn,Decoct 2 times, each 70 minutes, merge 2 times decoction liquor, filter, the liquid extract that while being concentrated into 60 DEG C, relative density is 1.16,Obtain.
Embodiment 4
This Chinese medicine composition is the material medicine by following weighing scale: radix pseudostellariae 10-19g, Psoralea corylifolia 5-9g, fruit of Chinese wolfberry 10-19g,Stem of noble dendrobium 5-17g, radix polygonati officinalis 10-14g, cordate houttuynia 10-19g, wolf's milk 10-19g, Han dish 10-19g, pseudo-ginseng 3-5g, chicken bloodRattan 10-19g and madder 5-9g make, and wherein, above-mentioned raw materials medicine are mixed, and use distilled water immersion 1 hour, everyThe ethanol that the inferior volumetric concentration that adds material medicine 4-6 times weight is 70%, decocts 2 times, each 70 minutes, merges 2 decoctionsLiquid, filters, and the liquid extract that while being concentrated into 60 DEG C, relative density is 1.16, to obtain final product.
Embodiment 5
This Chinese medicine composition is the material medicine by following weighing scale: radix pseudostellariae 21-30g, Psoralea corylifolia 11-15g, the fruit of Chinese wolfberry21-30g, stem of noble dendrobium 19-30g, radix polygonati officinalis 16-20g, cordate houttuynia 21-30g, wolf's milk 21-30g, Han dish 21-30g, pseudo-ginseng 7-10g,Reticulate millettia 21-30g and madder 11-15g make, and wherein, above-mentioned raw materials medicine are mixed, little with distilled water immersion 1Time, add the ethanol that the water of material medicine 4-6 times weight or the volumetric concentration of 4-6 times of weight are 70% at every turn, decoct 2 times, everyInferior 70 minutes, merge 2 times decoction liquor, filter, the liquid extract that while being concentrated into 60 DEG C, relative density is 1.16, to obtain final product.
The foregoing is only best case study on implementation of the present invention, is only illustrative for the purpose of the present invention, and nonrestrictive.Those skilled in the art is understood, and can carry out some amendments to it, but all will fall in the scope of the claims in the present inventionIn protection scope of the present invention.
The present invention have tonify the liver and kidney, effect of nourishing qi and blood, clearing heat and promoting fluid, promoting blood circulation, can effectively improve long-term radiation and makeThe hematopoiesis function damage, the immunity degradation etc. that become, curative effect is sure, through repeated tests, has all obtained useful technique effect,Correlation test data is as follows:
One, Antiradiation injury pharmacodynamic experiment
1. materials and methods
1.1 material
SPF level Kunming mouse, in age in 6-8 week, male, Mouse Weight is 18-22g, 50.
1.2 animal grouping and methods
Experiment is divided into Normal group, irradiation control group, Chinese medicine preparation high dose group of the present invention (TCM-H), middle dosage group(TCM-M), low dose group (TCM-L). The disposable full-body exposure of 60Co gamma-rays, 3.2 seconds/cGy of close rate, irradiation field25cm × 25cm, ource-skin Distance 80cm, exposure dose 6Gy. 60Co γ respectively at experiment first day and the tenth day with same dosageIrradiate. After irradiation, mouse is total to gastric infusion 20 days. Variable concentrations Chinese medicine preparation of the present invention (12,24,48g/kg) 0.2mlGavage, control group is with 0.2ml physiological saline gavage. Test the 20th day, detect each experimental index, finish experiment.
2. detect index
2.1 analysis on hemogram
Measure leucocyte, red blood cell and platelet count with blood-counter system, and record result.
2.2 bone marrow nucleated cell countings
Get a side femur, clean with normal saline flushing, cut off two ends epiphysis, with No. 7 needle pierces femur ends, use PBSLiquid rinses ossis repeatedly, until femur punching is white (at least 10 times). The bone marrow fluid of going out is by No. 4 syringe needle mistakesFilter stand-by. Get 0.5ml4% acetic acid and 0.5ml bone marrow fluid and be placed in another test tube and mix, place 2 minutes, again fully mix, soAfter get a little and splash into tally, count under the microscope karyocyte. Number of nucleated cells (L)=4 large grid karyocyte sum/ 4 × 104 × extension rate
2.3 thymus gland and spleen weight
Experiment finishes to get spleen, and assay balance is weighed. Spleen index=spleen weight/body weight × 1000
2.4 statistical analysis
Experimental result all withRepresent, adopt SPSS15.0 statistical package to carry out statistical analysis. Adopt single factor variance to divideAnalyse (ANOVA), between group, compare between two, adopt the inspection of LSD method, P < 0.05 has conspicuousness for difference.
3 results
The impact of 3.1 the present invention on radiation murine peripheral hemogram
Studies show that, the obvious reduction of irradiation control group leucocyte, red blood cell and blood platelet and Normal group, the present invention is eachDosage group energy increasing leukocyte, red blood cell and platelet counts, with irradiation control group comparison, have remarkable statistical significance (P <0.05). In table 1.
The impact of table 1 the present invention on radiation murine peripheral hemogram
With model group comparison, * P < 0.05, * * P < 0.01
3.2 the present invention are heavy on radiation murine bone marrow nucleated cell number and mice spleen, the impact of spleen index
Spleen is maximum lymphoid organ, is also one of important peripheral immune organ, contains a large amount of T cell, NKTThe killer cell of cell and Lymphokine etc. Spleen is also the place that haematogenous antigen is produced to immune response, can synthesize alsoSecretion is as the bioactivator such as complement, IFN, and spleen weight and index and spleen index have reflected the immune state of body indirectly. Studies show that,Irradiation control group mice spleen weight and spleen index, bone marrow nucleated cell digital display work reduce, and the high, medium and low dosage group of the present invention significantly risesThe high heavy and spleen index of the spleen of mouse after irradiating, high, the middle dosage group of the present invention and irradiation control group comparison, have obvious statistics to anticipateJustice (P < 0.05), low, the middle dosage group of the present invention and irradiation control group comparison, have remarkable statistical significance (P < 0.05), thisInvention high dose group and irradiation control group comparison, have and significant difference (P < 0.01). In table 2.
Table 2 the present invention is heavy on radiation murine bone marrow nucleated cell number and mice spleen, the impact of spleen index
With model group comparison, * P < 0.05, * * P < 0.01
Two, clinical trial
1. materials and methods
1.1 material
Collect case 90 examples, be pathology and make a definite diagnosis tumor patient, all do not accept radiotherapy. Wherein male 48 examples, female's 42 examples;Nasopharyngeal carcinoma 15 examples, 20 cases of breast cancer, lung cancer 33 examples, glioma 4 examples, the cancer of the esophagus 18 examples, age 30-75 year, flatEqual 54 years old. >=60 points of Karnofsky scorings, without radiotherapy contraindication. Patient is divided into 2 groups at random, treatment group 44 examples are rightAccording to group 46 examples, two groups at equal no difference of science of statistics in aspect such as sex, age, the state of an illness.
1.2 therapeutic scheme
All patients accept radiotherapy, and radiotherapy technology comprises three dimensional conformal radiation therapy and conventional radiotheraphy, during all Patients Treated by Radiotherapies notWith chemotherapy, immunization therapy or the treatment of other Chinese herbal medicine for preventing. Control group: patient accepts radiation alone. Treatment group: control at control groupOn the basis for the treatment of, it is oral that Chinese medicine composition of the present invention is pressed crude drug concentration 0.65-1.35g/ml water drug-decocting concentrating liquid 200ml, once a day,Treat altogether 2 months.
1.3 observation index
Prosperous according to NCI-CTC[week border. practical Internal Medicine-Oncology is learned [M] .2 version. Beijing: People's Health Publisher, 2003:29.] classification markThe accurate leucocyte decline degree of observing, detects T lymphocyte subsets situation before all patient treatments and after treatment.
1.4 statistical analysis
Experimental result all withRepresent, adopt SPSS15.0 statistical package to carry out statistical analysis. Adopt single factor variance to divideAnalyse (ANOVA), P < 0.05 has conspicuousness for difference.
2 experimental results
The impact of 2.1 the present invention on radiotherapy patient leucocyte decline degree
Experimental result shows, treatment group is being improved after radiotherapy aspect leucocyte decline degree, and its result for the treatment of is obviously better than control group,2 groups relatively have remarkable significant difference. In table 3.
Table 3 treatment group and control group are to the comparison of radiotherapy patient leucocyte decline degree [example (%)]
With relatively △ P < 0.05 of control group
The impact of 2.2 the present invention on radiotherapy patient T cell subsets
Originally studies show that, after treatment of control group, with this group before treatment, CD3 cell and CD4/CD8 ratio significantly reduce,After prompting radiotherapy, Immune Function is low. And after treatment group treatment, with comparison after treatment of control group, CD3 cell ratioExample and CD4/CD8 ratio raise, and significant difference is remarkable, have shown the facilitation that the present invention recovers body's immunity.In table 4.
Table 4 liang group patient T cell subsets comparison
With this group before treatment, △ P < 0.05, △ △ P < 0.01; With comparison * P < 0.05 after treatment of control group, * * P < 0.01
Chinese medicine composition of the present invention has effect of Antiradiation injury, improving the hematopoiesis function damage that radiation causes, improves bodyImmunity aspect, curative effect is sure, is the innovation on radiopharmaceutical, has actual clinical meaning.
Claims (7)
1. prevent and treat the Chinese medicine composition of radiation for one kind, it is characterized in that, this Chinese medicine composition is the material medicine by following weighing scale: radix pseudostellariae 10-30g, Psoralea corylifolia 5-15g, fruit of Chinese wolfberry 10-30g, stem of noble dendrobium 5-30g, radix polygonati officinalis 10-20g, cordate houttuynia 10-30g, wolf's milk 10-30g, Han dish 10-30g, pseudo-ginseng 3-10g, reticulate millettia 10-30g and madder 5-15g make, wherein, above-mentioned raw materials medicine is mixed, with distilled water immersion 1 hour, add the ethanol that the water of material medicine 4-6 times weight or the volumetric concentration of 4-6 times of weight are 70% at every turn, decoct 2 times, each 70 minutes, merge 2 times decoction liquor, filter, the liquid extract that while being concentrated into 60 DEG C, relative density is 1.16, obtain.
2. the Chinese medicine composition of control radiation according to claim 1, it is characterized in that, this Chinese medicine composition is the material medicine by following weighing scale: radix pseudostellariae 10g, Psoralea corylifolia 5g, fruit of Chinese wolfberry 10g, stem of noble dendrobium 5g, radix polygonati officinalis 10g, cordate houttuynia 10g, wolf's milk 10g, Han dish 10g, pseudo-ginseng 3g, reticulate millettia 10g and madder 5g make, wherein, above-mentioned raw materials medicine is mixed, with distilled water immersion 1 hour, add the water of 4 times of weight of material medicine at every turn, decoct 2 times, each 70 minutes, merge 2 times decoction liquor, filter, the liquid extract that while being concentrated into 60 DEG C, relative density is 1.16, obtain.
3. the Chinese medicine composition of control radiation according to claim 1, it is characterized in that, this Chinese medicine composition is the material medicine by following weighing scale: radix pseudostellariae 20g, Psoralea corylifolia 10g, fruit of Chinese wolfberry 20g, stem of noble dendrobium 18g, radix polygonati officinalis 15g, cordate houttuynia 20g, wolf's milk 20g, Han dish 20g, pseudo-ginseng 6g, reticulate millettia 20g and madder 10g make, wherein, above-mentioned raw materials medicine is mixed, with distilled water immersion 1 hour, the ethanol that the volumetric concentration that at every turn adds 5 times of weight of material medicine is 70%, decoct 2 times, each 70 minutes, merge 2 times decoction liquor, filter, the liquid extract that while being concentrated into 60 DEG C, relative density is 1.16, obtain.
4. the Chinese medicine composition of control radiation according to claim 1, it is characterized in that, this Chinese medicine composition is the material medicine by following weighing scale: radix pseudostellariae 30g, Psoralea corylifolia 15g, fruit of Chinese wolfberry 30g, stem of noble dendrobium 30g, radix polygonati officinalis 20g, cordate houttuynia 30g, wolf's milk 30g, Han dish 30g, pseudo-ginseng 10g, reticulate millettia 30g and madder 15g make, wherein, above-mentioned raw materials medicine is mixed, with distilled water immersion 1 hour, add the water of 6 times of weight of material medicine at every turn, decoct 2 times, each 70 minutes, merge 2 times decoction liquor, filter, the liquid extract that while being concentrated into 60 DEG C, relative density is 1.16, obtain.
5. the Chinese medicine composition of control radiation according to claim 1, it is characterized in that, this Chinese medicine composition is the material medicine by following weighing scale: radix pseudostellariae 10-19g, Psoralea corylifolia 5-9g, fruit of Chinese wolfberry 10-19g, stem of noble dendrobium 5-17g, radix polygonati officinalis 10-14g, cordate houttuynia 10-19g, wolf's milk 10-19g, Han dish 10-19g, pseudo-ginseng 3-5g, reticulate millettia 10-19g and madder 5-9g make, wherein, above-mentioned raw materials medicine is mixed, with distilled water immersion 1 hour, the ethanol that the volumetric concentration that at every turn adds material medicine 4-6 times weight is 70%, decoct 2 times, each 70 minutes, merge 2 times decoction liquor, filter, the liquid extract that while being concentrated into 60 DEG C, relative density is 1.16, obtain.
6. the Chinese medicine composition of control radiation according to claim 1, it is characterized in that, this Chinese medicine composition is the material medicine by following weighing scale: radix pseudostellariae 21-30g, Psoralea corylifolia 11-15g, fruit of Chinese wolfberry 21-30g, stem of noble dendrobium 19-30g, radix polygonati officinalis 16-20g, cordate houttuynia 21-30g, wolf's milk 21-30g, Han dish 21-30g, pseudo-ginseng 7-10g, reticulate millettia 21-30g and madder 11-15g make, wherein, above-mentioned raw materials medicine is mixed, with distilled water immersion 1 hour, add the ethanol that the water of material medicine 4-6 times weight or the volumetric concentration of 4-6 times of weight are 70% at every turn, decoct 2 times, each 70 minutes, merge 2 times decoction liquor, filter, the liquid extract that while being concentrated into 60 DEG C, relative density is 1.16, obtain.
7. the Chinese medicine composition of the control radiation described in claim 1 or 2-6 any one is in the application of preparing in the tablet of auxiliary oncotherapy, granule, capsule, pill, oral liquid, any medicine of syrup.
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| CN104491688A (en) * | 2014-12-02 | 2015-04-08 | 国家电网公司 | Preparation method of biological agent for preventing electromagnetic radiation |
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