CN103585589B - 一种治疗慢性类风湿性关节炎的药物 - Google Patents
一种治疗慢性类风湿性关节炎的药物 Download PDFInfo
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Abstract
本发明公开了一种治疗慢性类风湿性关节炎的药物，由以下按重量份计的组分组成：石膏25-30份，知母10-15份，桂枝15-20份，防己10-15份，薏米25-30份，穿山龙15-20份，木瓜15-20份，清风藤25-30份，海风藤25-30份，忍冬藤25-30份，苍术10-15份，黄柏10-15份，蒲公英10-15份，紫花地丁15-20份，白花蛇舌草25-30份，紫草10-15份，蜂房15-20份，土鳖虫10-15份，补骨脂10-15份，续断15-20份，胆南星10-15份，牛膝10-15份，白芍15-20份，鸡血藤25-30份，狗脊10-15份，车前子25-30份，僵蚕15-20份，虎杖15-20份，姜黄10-15份，甘草10-15份。
Description
技术领域
本发明涉及一种治疗类风湿性关节炎的药物。
背景技术
类风湿性关节炎是一种原因不明的慢性多系统疾病。对称性地累及外周关节的持续性滑膜炎是类风湿性关节炎特征性表现，而滑膜炎症可导致软骨破坏和骨质侵蚀，最终影响关节完整性继而引起关节强直、畸形而功能丧失。现西医临床常用改善病情药物、非甾类消炎药、糖皮质激素，免疫调节药物，抗细胞因子制剂通常会引起很多副作用。特别是急性期，通常会加大激素量易引起骨质疏松，胃粘膜损伤等副作用。
发明内容
本发明提供一种治疗慢性类风湿性关节炎的药物，利用中医中药解决慢性类风湿性关节炎的在急性期内的症状，避免使用西药给人带来的各种副作用及潜在较大的副作用。
为了实现上述发明目的，一种治疗慢性类风湿性关节炎的药物，由以下按重量份计的组分组成：
石膏25-30份，知母10-15份，桂枝15-20份，防己10-15份，薏米25-30份，穿山龙15-20份，木瓜15-20份，清风藤25-30份，海风藤25-30份，忍冬藤25-30份，苍术10-15份，黄柏10-15份，蒲公英10-15份，紫花地丁15-20份，白花蛇舌草25-30份，紫草10-15份，蜂房15-20份，土鳖虫10-15份，补骨脂10-15份，续断15-20份，胆南星10-15份，牛膝10-15份，白芍15-20份，鸡血藤25-30份，狗脊10-15份，车前子25-30份，僵蚕15-20份，虎杖15-20份，姜黄10-15份，甘草10-15份。
本发明根据类风湿关节炎的发病病因病理，通过祛风去湿，通经、活血、行气、止痛、补肝肾、强筋骨的办法进行调理达到治愈的目的。其中各个组分的功效如下：石膏：清热泻火，为方中君药之一。
知母：清热泻火，生津润燥。
桂枝：祛风湿而善达四肢经络，通利关节，痹症新久、寒热均可适用。
防己：辛能散，苦寒降泄，既能祛风除湿止痛又能清热，对风湿痹症湿热偏盛，肢体酸重，关节红肿疼痛尤宜。
薏米：利湿消肿，健脾而利湿。
车前子：利水通淋，渗湿，使湿邪从小便出。
木瓜：舒筋活络，和胃化湿，祛风利关节。
穿山龙：祛风湿，活血通络，因微寒清热治热证适宜，血热易致血瘀。
清风藤：清热解毒通络，主要有效成分为青藤碱，具有抗炎镇痛、抗风湿及免疫抑制等多方面的药理作用。青风藤及其制剂临床用于RA的治疗，具有起效快、疗效确切、应用范围广、毒副作用小等优点。
海风藤：有效成分新木脂素类中海风藤酮已被实验证实为血小板活化因子(PAF)受体拮抗剂，而PAF是一种与花生四烯酸代谢密切相关的内源性活性脂质介质，具有广泛的生物学效应，在血栓、哮喘、溃疡、炎症、心脑血管缺血性疾病的发病中起主要作用。
忍冬藤：清热利湿，利关节。
苍术：燥湿健脾，祛风散寒。
黄柏：清热燥湿，泻火解毒，与苍术、牛膝、薏米共组四妙丸有清热利湿之功。
蒲公英：清热解毒、消痈散结、凉血、利尿。
紫花地丁：清热解毒，凉血消肿。
白花蛇舌草：清热解毒，利湿通淋，是现代研究表明有一定的免疫调节作用。
紫草：凉血活血，清热解毒，防热毒。
蜂房：清热通络祛风。
土鳖虫：祛瘀止血，消肿止痛，通络理伤，接筋续骨。
补骨脂：其性大温，味辛、苦、入脾、肾经，具有补肾壮阳、止泻功效，有较强的雌性激素样作用。补骨脂中的黄酮化合物补骨脂异黄酮和补骨脂二氧黄酮在体外有直接促进骨细胞增殖和分化活性，有抗骨质疏松作用。
续断：补肝肾；强筋骨；调血脉；续折伤。
胆南星：清热化痰，息风定惊。
牛膝：活血通经，补肝肾，强筋骨，利水通淋，引血下行，为引经药。
白芍：苦、酸、微寒，入肝经。具有平肝止痛、养血调经、敛阴止汗、补血和血，缓急止痛功效。其有效成分白芍总甙及芍药甙均有一定的镇痛作用。实践证明，白芍对急性渗出性炎症及增生性炎症均有效。
鸡血藤：行血补血，舒筋通络，活血化瘀。
狗脊；补肝肾，强腰膝，坚筋骨，能行能补。
僵蚕：祛风定惊、化痰散结。
虎杖：清热解毒，利胆退黄，祛风利湿，散瘀定痛。
姜黄：破血行气，通经止痛。
甘草：解毒和中，调和诸药。
本发明根据中医理论，辩证施治，标本兼治的理念，达到治愈病情的目的。本发明产品使用方便、价廉、疗效好，能显著改善并解除疼痛症状，常规剂量下使用未发现副作用。其疗效明显优于针灸、推拿、穴位注射及其他中药，而且还能避免晕针、感染及推拿不到位而导致的局部损伤或加重；与西药相比没有消炎激素类药物的各种副作用。
具体实施方式
取以下药物量进行配制：
石膏30g，知母10g，桂枝15g，防己15g，薏米30g，穿山龙20g，木瓜15g，清风藤30g，海风藤30g，忍冬藤30g，苍术15g，黄柏10g，蒲公英15g，紫花地丁15g，白花蛇舌草30g，紫草15g，蜂房15g，土鳖虫10g，补骨脂15g，续断15g，胆南星10g，牛膝10g，白芍15g，鸡血藤30g，狗脊15g，车前子30g，僵蚕15g，虎杖15g，姜黄10g，甘草10g；将以上药物煎熬制成汤剂进行服用。
病例1、患者朱某，女65岁，有类风湿性关节炎一年余，复发5天就诊，见周身关节超过15个疼痛，尤以腕关节、肘关节、膝关节为重，关节肿胀疼痛红肿灼热，晨僵明显，口干，口苦，大便干结，步履艰难，小便黄，舌红，苔黄，干裂，脉滑数，查体：关节肿胀，压痛(+)双膝关节可见baker囊肿，关节明显活动受限，验血结果为：RF166Iu/ml、ESR103m/h、CRP60mg/l，经上方治疗30剂后，关节肿胀消退，活动自如，自如行走，查体：关节活动无明显受限，压痛(-)皮温肤色正常，复查：ESR15、CRP2.0、RF16，表明炎症得到有效控制。
病例2、患者仇某，女，78岁，有类风湿性关节炎多年，复发2天就诊，见周身关节超过10个疼痛，尤以腕关节、膝关节为重，关节肿胀疼痛红肿灼热，，口干，步履艰难，小便黄，舌红，苔黄，查体：关节肿胀，压痛(+)关节活动受限，查RF128、ESR94、CRP72，经上方治疗30剂后，关节肿胀消退，活动自如，自如行走，查体：关节活动无明显受限，压痛(-)皮温肤色正常，复查：血液的ESR13、CRP2.1、RF15，表明炎症得到有效控制。
Claims (1)
1.一种治疗慢性类风湿性关节炎的药物，其特征在于：由以下按重量份计的组分组成：
石膏25-30份，知母10-15份，桂枝15-20份，防己10-15份，薏米25-30份，穿山龙15-20份，木瓜15-20份，清风藤25-30份，海风藤25-30份，忍冬藤25-30份，苍术10-15份，黄柏10-15份，蒲公英10-15份，紫花地丁15-20份，白花蛇舌草25-30份，紫草10-15份，蜂房15-20份，土鳖虫10-15份，补骨脂10-15份，续断15-20份，胆南星10-15份，牛膝10-15份，白芍15-20份，鸡血藤25-30份，狗脊10-15份，车前子25-30份，僵蚕15-20份，虎杖15-20份，姜黄10-15份，甘草10-15份。
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| CN1229658A (zh) * | 1998-03-24 | 1999-09-29 | 刘月江 | 复方三痹痛风药酒 |
| CN1375298A (zh) * | 2001-01-04 | 2002-10-23 | 黄兆元 | 三七复方止痛合剂 |
| CN101703708A (zh) * | 2009-11-10 | 2010-05-12 | 卢速江 | 一种治疗类风湿关节炎、痛风的中药制剂及其制备方法 |
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| CN1229658A (zh) * | 1998-03-24 | 1999-09-29 | 刘月江 | 复方三痹痛风药酒 |
| CN1375298A (zh) * | 2001-01-04 | 2002-10-23 | 黄兆元 | 三七复方止痛合剂 |
| CN101703708A (zh) * | 2009-11-10 | 2010-05-12 | 卢速江 | 一种治疗类风湿关节炎、痛风的中药制剂及其制备方法 |
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