CN103582419A - 有效量的(3aR)-1,3a,8-三甲基-1,2,3,3a,8,8a-六氢吡咯并[2,3-b]吲哚-5-基氨基甲酸苯酯及其方法 - Google Patents

有效量的(3aR)-1,3a,8-三甲基-1,2,3,3a,8,8a-六氢吡咯并[2,3-b]吲哚-5-基氨基甲酸苯酯及其方法 Download PDF

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CN103582419A
CN103582419A CN201280021686.1A CN201280021686A CN103582419A CN 103582419 A CN103582419 A CN 103582419A CN 201280021686 A CN201280021686 A CN 201280021686A CN 103582419 A CN103582419 A CN 103582419A
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administration
administering
acid
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Chinese (zh)
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M·马切克基尼
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Annovis Bio Inc
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QR Pharma Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201280021686.1A 2011-03-04 2012-02-28 有效量的(3aR)-1,3a,8-三甲基-1,2,3,3a,8,8a-六氢吡咯并[2,3-b]吲哚-5-基氨基甲酸苯酯及其方法 Pending CN103582419A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/041,211 2011-03-04
US13/041,211 US20120225922A1 (en) 2011-03-04 2011-03-04 Effective Amounts of (3aR)-1,3a,8-Trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo [2,3-b]indol-5-yl Phenylcarbamate and Methods of Treating or Preventing Neurodegeneration
PCT/US2012/026984 WO2012154285A1 (en) 2011-03-04 2012-02-28 Effective amounts of (3ar)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl phenylcarbamate and methods thereof

Publications (1)

Publication Number Publication Date
CN103582419A true CN103582419A (zh) 2014-02-12

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CN201280021686.1A Pending CN103582419A (zh) 2011-03-04 2012-02-28 有效量的(3aR)-1,3a,8-三甲基-1,2,3,3a,8,8a-六氢吡咯并[2,3-b]吲哚-5-基氨基甲酸苯酯及其方法

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US (9) US20120225922A1 (enExample)
EP (1) EP2683242B8 (enExample)
JP (2) JP2014513065A (enExample)
KR (1) KR20140019361A (enExample)
CN (1) CN103582419A (enExample)
AU (1) AU2012254093B2 (enExample)
BR (1) BR112013022673A2 (enExample)
CA (1) CA2829039C (enExample)
DK (1) DK2683242T3 (enExample)
WO (1) WO2012154285A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120225922A1 (en) * 2011-03-04 2012-09-06 Qr Pharma Effective Amounts of (3aR)-1,3a,8-Trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo [2,3-b]indol-5-yl Phenylcarbamate and Methods of Treating or Preventing Neurodegeneration
CA2994974C (en) * 2015-08-14 2024-04-09 Qr Pharma Methods of treatment or prevention of acute brain or nerve injuries
WO2018217892A1 (en) * 2017-05-24 2018-11-29 Qr Pharma, Inc. Prevention or treatment of disease states due to metal dis-homeostasis via administration of posiphen to healthy or sick humans
WO2020061404A1 (en) * 2018-09-21 2020-03-26 Aristea Translational Medicine Corporation Compositions and methods for inhibiting brain trauma-induced neurodegeneration and related conditions
BR112021007476A2 (pt) 2018-11-21 2021-11-03 Ionis Pharmaceuticals Inc Compostos e métodos para reduzir a expressão de príon
WO2021067864A1 (en) * 2019-10-02 2021-04-08 Sangamo Therapeutics, Inc. Zinc finger protein transcription factors for treatment of prion disease
US20220370412A1 (en) * 2021-05-18 2022-11-24 Annovis Bio, Inc. Inhibition of neurological injuries due to infections via administration of butanetap and analogs thereof
WO2023164696A2 (en) * 2022-02-28 2023-08-31 Ionis Pharmaceuticals, Inc. Rnai agents of prion expression
EP4629980A1 (en) * 2022-12-06 2025-10-15 SRI International Antimicrobial compounds
WO2024263878A2 (en) * 2023-06-21 2024-12-26 Annovis Bio, Inc. Solid forms of posiphen d-tartrate

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020094999A1 (en) * 1997-07-09 2002-07-18 Greig Nigel H. Highly selective butyrylcholinesterase inhibitors for the treatment and diagnosis of Alzheimer's disease and dementias
US20050013869A1 (en) * 2003-07-18 2005-01-20 Chaw Cheng Shu Sustained release formulation for carbamates and a method therefor

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5171750A (en) 1991-09-26 1992-12-15 The United States Of America As Represented By The Department Of Health And Human Services Substituted phenserines as specific inhibitors of acetylcholinesterase
US5409948A (en) * 1992-11-23 1995-04-25 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method for treating cognitive disorders with phenserine
ATE345803T1 (de) 2000-03-03 2006-12-15 Eisai Co Ltd Neue methoden unter verwendung von cholinesteraseinhibitoren
CA2465534C (en) 2000-11-02 2009-10-27 Nigel H. Greig Agents useful for reducing amyloid precursor protein and treating dementia and methods of use thereof
WO2003024450A1 (en) * 2001-09-20 2003-03-27 Eisai Co., Ltd. Methods for treating prion diseases
US6495700B1 (en) 2002-01-09 2002-12-17 Axonyx, Inc. Process for producing phenserine and its analog
US20040024043A1 (en) * 2002-03-22 2004-02-05 Nigel Greig Method for treating cognitive disorders
WO2004034963A2 (en) 2002-05-17 2004-04-29 Eisai Co., Ltd. Methods and compositions using cholinesterase inhibitors
US20050031651A1 (en) * 2002-12-24 2005-02-10 Francine Gervais Therapeutic formulations for the treatment of beta-amyloid related diseases
EP1617844A4 (en) 2003-04-03 2009-07-22 Prana Biotechnology Ltd TREATMENT OF NEUROLOGICAL DISEASES
US20050182044A1 (en) 2004-02-17 2005-08-18 Bruinsma Gosse B. Combinatorial therapy with an acetylcholinesterase inhibitor and (3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3,-b]indol-5-yl phenylcarbamate
WO2005089746A1 (en) * 2004-03-19 2005-09-29 Axonyx, Inc. Dosage titration for treatment of cognitive disorders
WO2005091987A2 (en) 2004-03-19 2005-10-06 Axonyx, Inc. Method of treating down syndrome
CA2509265A1 (en) * 2004-06-08 2005-12-08 Axonyx, Inc. Methods of delaying alzheimer's disease progression using a beta-amyloid precursor protein inhibitor and hmg coa reductase inhibitor
US20060160852A1 (en) * 2004-12-27 2006-07-20 Eisai Co. Ltd. Composition containing anti-dementia drug
US7858803B2 (en) 2007-04-27 2010-12-28 The General Hospital Corporation Imaging tracers for early detection and treatment of amyloid plaques caused by Alzheimer's disease and related disorders
AU2008262438A1 (en) * 2007-06-07 2008-12-18 Dynogen Pharmaceuticals, Inc. Compositions useful for treating gastroesophageal reflux disease
JP4690362B2 (ja) * 2007-07-04 2011-06-01 株式会社リコー Ｓｉｍｄ型マイクロプロセッサおよびｓｉｍｄ型マイクロプロセッサのデータ転送方法
WO2010117727A2 (en) * 2009-03-30 2010-10-14 The General Hospital Corporation Phenserine and posiphen for treating neuropsychiatric and neurodegenerative conditions
US20120225922A1 (en) 2011-03-04 2012-09-06 Qr Pharma Effective Amounts of (3aR)-1,3a,8-Trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo [2,3-b]indol-5-yl Phenylcarbamate and Methods of Treating or Preventing Neurodegeneration

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020094999A1 (en) * 1997-07-09 2002-07-18 Greig Nigel H. Highly selective butyrylcholinesterase inhibitors for the treatment and diagnosis of Alzheimer's disease and dementias
US20050013869A1 (en) * 2003-07-18 2005-01-20 Chaw Cheng Shu Sustained release formulation for carbamates and a method therefor

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MACCECCHINI ET AL: "Posiphen lowers amyloid precursor protein and amyloid β as well as acetylcholinesterase levels in culture, animals and humans", 《INTERNATIONAL CONFERENCE ON ALZHEIMER’S DISEASE》, 12 July 2009 (2009-07-12), pages 287 *

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Publication number Publication date
DK2683242T3 (da) 2020-07-06
EP2683242B1 (en) 2020-04-08
US11096926B2 (en) 2021-08-24
CA2829039C (en) 2021-09-14
US20200375947A1 (en) 2020-12-03
US20150374664A1 (en) 2015-12-31
CA2829039A1 (en) 2012-11-15
EP2683242A4 (en) 2014-09-03
US11382893B2 (en) 2022-07-12
US20210093610A1 (en) 2021-04-01
AU2012254093B2 (en) 2015-08-06
US11376238B2 (en) 2022-07-05
EP2683242A1 (en) 2014-01-15
US20220323413A1 (en) 2022-10-13
US12144798B2 (en) 2024-11-19
US20170304266A1 (en) 2017-10-26
US20200375948A1 (en) 2020-12-03
EP2683242B8 (en) 2020-06-03
KR20140019361A (ko) 2014-02-14
JP2018076332A (ja) 2018-05-17
US10383851B2 (en) 2019-08-20
US20120225922A1 (en) 2012-09-06
US11400075B2 (en) 2022-08-02
JP2014513065A (ja) 2014-05-29
US20250114330A1 (en) 2025-04-10
WO2012154285A1 (en) 2012-11-15
AU2012254093A1 (en) 2013-09-26
US20190381007A1 (en) 2019-12-19
BR112013022673A2 (pt) 2017-03-28

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Application publication date: 20140212