CA2829039C - Effective amounts of (3ar)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl phenylcarbamate and methods thereof - Google Patents
Effective amounts of (3ar)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl phenylcarbamate and methods thereof Download PDFInfo
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- CA2829039C CA2829039C CA2829039A CA2829039A CA2829039C CA 2829039 C CA2829039 C CA 2829039C CA 2829039 A CA2829039 A CA 2829039A CA 2829039 A CA2829039 A CA 2829039A CA 2829039 C CA2829039 C CA 2829039C
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- 235000007586 terpenes Nutrition 0.000 description 1
- TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 1
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- 229940126585 therapeutic drug Drugs 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/041,211 US20120225922A1 (en) | 2011-03-04 | 2011-03-04 | Effective Amounts of (3aR)-1,3a,8-Trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo [2,3-b]indol-5-yl Phenylcarbamate and Methods of Treating or Preventing Neurodegeneration |
| US13/041,211 | 2011-03-04 | ||
| PCT/US2012/026984 WO2012154285A1 (en) | 2011-03-04 | 2012-02-28 | Effective amounts of (3ar)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl phenylcarbamate and methods thereof |
Publications (2)
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| CA2829039A1 CA2829039A1 (en) | 2012-11-15 |
| CA2829039C true CA2829039C (en) | 2021-09-14 |
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| CA2829039A Active CA2829039C (en) | 2011-03-04 | 2012-02-28 | Effective amounts of (3ar)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl phenylcarbamate and methods thereof |
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| US (9) | US20120225922A1 (enExample) |
| EP (1) | EP2683242B8 (enExample) |
| JP (2) | JP2014513065A (enExample) |
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| CN (1) | CN103582419A (enExample) |
| AU (1) | AU2012254093B2 (enExample) |
| BR (1) | BR112013022673A2 (enExample) |
| CA (1) | CA2829039C (enExample) |
| DK (1) | DK2683242T3 (enExample) |
| WO (1) | WO2012154285A1 (enExample) |
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| US20120225922A1 (en) | 2011-03-04 | 2012-09-06 | Qr Pharma | Effective Amounts of (3aR)-1,3a,8-Trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo [2,3-b]indol-5-yl Phenylcarbamate and Methods of Treating or Preventing Neurodegeneration |
| CA2994974C (en) * | 2015-08-14 | 2024-04-09 | Qr Pharma | Methods of treatment or prevention of acute brain or nerve injuries |
| EP3654957A4 (en) | 2017-05-24 | 2021-06-23 | Annovis Bio, Inc. | PREVENTION OR TREATMENT OF DISEASE CONDITIONS DUE TO METAL DIS-HOMEOSTASIS BY ADMINISTERING POSIPHES TO HEALTHY OR SICK PEOPLE |
| WO2020061404A1 (en) * | 2018-09-21 | 2020-03-26 | Aristea Translational Medicine Corporation | Compositions and methods for inhibiting brain trauma-induced neurodegeneration and related conditions |
| US12281305B2 (en) | 2018-11-21 | 2025-04-22 | Ionis Pharmaceuticals, Inc. | Compounds and methods for reducing prion expression |
| US20230002459A1 (en) * | 2019-10-02 | 2023-01-05 | Sangamo Therapeutics, Inc. | Zinc Finger Protein Transcription Factors for Treatment of Prion Disease |
| US20220370412A1 (en) * | 2021-05-18 | 2022-11-24 | Annovis Bio, Inc. | Inhibition of neurological injuries due to infections via administration of butanetap and analogs thereof |
| JP2025507749A (ja) * | 2022-02-28 | 2025-03-21 | アイオーニス ファーマシューティカルズ， インコーポレーテッド | プリオン発現のＲＮＡｉ剤 |
| WO2024123663A1 (en) * | 2022-12-06 | 2024-06-13 | Sri International | Antimicrobial compounds |
| WO2024263878A2 (en) * | 2023-06-21 | 2024-12-26 | Annovis Bio, Inc. | Solid forms of posiphen d-tartrate |
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| US5409948A (en) * | 1992-11-23 | 1995-04-25 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method for treating cognitive disorders with phenserine |
| ES2255170T3 (es) * | 1997-07-09 | 2006-06-16 | Axonyx | Inhibidores de butirilcolinesterasa altamente selectivos para el tratamiento y diagnostico de demencias y de la enfermedad de alzheimer. |
| EP1311272B1 (en) | 2000-03-03 | 2006-11-22 | Eisai Co., Ltd. | Novel methods using cholinesterase inhibitors |
| DE60135579D1 (de) | 2000-11-02 | 2008-10-09 | Us Gov Health & Human Serv | Wirkstoffe für die verminderung von amyloid precursor protein und die behandlung von schwachsinn, und deren verfahren der verwendung |
| WO2003024450A1 (en) * | 2001-09-20 | 2003-03-27 | Eisai Co., Ltd. | Methods for treating prion diseases |
| US6495700B1 (en) | 2002-01-09 | 2002-12-17 | Axonyx, Inc. | Process for producing phenserine and its analog |
| US20040024043A1 (en) * | 2002-03-22 | 2004-02-05 | Nigel Greig | Method for treating cognitive disorders |
| WO2004034963A2 (en) | 2002-05-17 | 2004-04-29 | Eisai Co., Ltd. | Methods and compositions using cholinesterase inhibitors |
| US20050031651A1 (en) * | 2002-12-24 | 2005-02-10 | Francine Gervais | Therapeutic formulations for the treatment of beta-amyloid related diseases |
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| US20050013869A1 (en) * | 2003-07-18 | 2005-01-20 | Chaw Cheng Shu | Sustained release formulation for carbamates and a method therefor |
| US20050182044A1 (en) | 2004-02-17 | 2005-08-18 | Bruinsma Gosse B. | Combinatorial therapy with an acetylcholinesterase inhibitor and (3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3,-b]indol-5-yl phenylcarbamate |
| WO2005091987A2 (en) | 2004-03-19 | 2005-10-06 | Axonyx, Inc. | Method of treating down syndrome |
| WO2005089746A1 (en) * | 2004-03-19 | 2005-09-29 | Axonyx, Inc. | Dosage titration for treatment of cognitive disorders |
| WO2005123068A2 (en) | 2004-06-08 | 2005-12-29 | Axonyx, Inc. | Methods of dealying alzheimer’s disease progression using a beta-amyloid precursor protein inhibitor and a hmg coa reductase inhibitor |
| US20060160852A1 (en) * | 2004-12-27 | 2006-07-20 | Eisai Co. Ltd. | Composition containing anti-dementia drug |
| US7858803B2 (en) | 2007-04-27 | 2010-12-28 | The General Hospital Corporation | Imaging tracers for early detection and treatment of amyloid plaques caused by Alzheimer's disease and related disorders |
| CA2690581A1 (en) * | 2007-06-07 | 2008-12-18 | Dynogen Pharmaceuticals, Inc. | Compositions useful for treating gastroesophageal reflux disease |
| JP4690362B2 (ja) * | 2007-07-04 | 2011-06-01 | 株式会社リコー | Ｓｉｍｄ型マイクロプロセッサおよびｓｉｍｄ型マイクロプロセッサのデータ転送方法 |
| WO2010117727A2 (en) * | 2009-03-30 | 2010-10-14 | The General Hospital Corporation | Phenserine and posiphen for treating neuropsychiatric and neurodegenerative conditions |
| US20120225922A1 (en) * | 2011-03-04 | 2012-09-06 | Qr Pharma | Effective Amounts of (3aR)-1,3a,8-Trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo [2,3-b]indol-5-yl Phenylcarbamate and Methods of Treating or Preventing Neurodegeneration |
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2011
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2012
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- 2012-02-28 DK DK12782326.8T patent/DK2683242T3/da active
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- 2012-02-28 WO PCT/US2012/026984 patent/WO2012154285A1/en not_active Ceased
- 2012-02-28 BR BR112013022673A patent/BR112013022673A2/pt not_active IP Right Cessation
- 2012-02-28 EP EP12782326.8A patent/EP2683242B8/en active Active
- 2012-02-28 CN CN201280021686.1A patent/CN103582419A/zh active Pending
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2015
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2017
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2019
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2024
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Also Published As
| Publication number | Publication date |
|---|---|
| CA2829039A1 (en) | 2012-11-15 |
| US11400075B2 (en) | 2022-08-02 |
| BR112013022673A2 (pt) | 2017-03-28 |
| US20200375947A1 (en) | 2020-12-03 |
| EP2683242A1 (en) | 2014-01-15 |
| AU2012254093B2 (en) | 2015-08-06 |
| JP2014513065A (ja) | 2014-05-29 |
| EP2683242B1 (en) | 2020-04-08 |
| US11376238B2 (en) | 2022-07-05 |
| US20200375948A1 (en) | 2020-12-03 |
| US20150374664A1 (en) | 2015-12-31 |
| US20220323413A1 (en) | 2022-10-13 |
| EP2683242A4 (en) | 2014-09-03 |
| US10383851B2 (en) | 2019-08-20 |
| US12144798B2 (en) | 2024-11-19 |
| WO2012154285A1 (en) | 2012-11-15 |
| KR20140019361A (ko) | 2014-02-14 |
| US20170304266A1 (en) | 2017-10-26 |
| JP2018076332A (ja) | 2018-05-17 |
| US11382893B2 (en) | 2022-07-12 |
| AU2012254093A1 (en) | 2013-09-26 |
| US20210093610A1 (en) | 2021-04-01 |
| DK2683242T3 (da) | 2020-07-06 |
| CN103582419A (zh) | 2014-02-12 |
| EP2683242B8 (en) | 2020-06-03 |
| US20250114330A1 (en) | 2025-04-10 |
| US11096926B2 (en) | 2021-08-24 |
| US20190381007A1 (en) | 2019-12-19 |
| US20120225922A1 (en) | 2012-09-06 |
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| Date | Code | Title | Description |
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| EEER | Examination request |
Effective date: 20170118 |