CN103566047B - A kind of cordyceps sinensis composition of blood fat reducing - Google Patents
A kind of cordyceps sinensis composition of blood fat reducing Download PDFInfo
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- CN103566047B CN103566047B CN201310634806.1A CN201310634806A CN103566047B CN 103566047 B CN103566047 B CN 103566047B CN 201310634806 A CN201310634806 A CN 201310634806A CN 103566047 B CN103566047 B CN 103566047B
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- cordyceps
- cordyceps sinensis
- sinensis composition
- cortex eucommiae
- herba cistanches
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Abstract
The invention discloses a kind of cordyceps sinensis composition, described compositions includes Herba Cistanches, Radix Ginseng, Radix Notoginseng, Fructus Mori, Semen Euryales, Fructus Lycii, the Cortex Eucommiae, Cordyceps and maca powder.Animal experiments prove that the cordyceps sinensis composition of the present invention can reduce Normal Mouse Serum positive C, LDL level, have compared with the more preferable effect of Cordyceps, it has certain auxiliary lipid-lowering function.
Description
Technical field
The invention belongs to the field of Chinese medicines, in particular to a kind of cordyceps sinensis composition with blood fat reducing function, with
Improve Cordyceps effect in terms of blood fat reducing.
Background technology
In recent years, along with factor impacts such as living habit and dietary habit changes, hyperlipemia disease sickness rate rises appreciably
Gesture, has become as one of healthy major disease of harm human body.The generation of dyslipidemia phase close with life factor
Close, as high fat diet, obesity, age increase the decline of lipolysaccharide metabolic capacity, estrogen deficiency or glucocorticoids medicine
Thing stimulates and long-term bad life habits etc..Hyperlipidemia can cause atherosclerosis, causes cardiovascular disease.High
Cholesterol and hyperlipoproteinemia are the Major Risk Factors of cardiovascular disease, after dyslipidemia occurs, and lipid shape in blood
Becoming fatty spew or fibrous plaque, cause arterial lumen narrow, tube wall hardens, and then causes a series of and blood vessel aspect disease
Sick relevant complication, such as angina pectoris, cerebral infarction is waited indefinitely.Also can be formed hypertension, diabetes, eye ground angiopathy,
Nephropathy and upper and lower limb gangrene etc., have a strong impact on quality of life and life security.Reducing blood plasma cholesterol level is that treatment is dynamic
The effective ways of pulse atherosclerosis disease, the coronary heart disease study on prevention that U.S. cardiopulmonary blood academy is carried out 7 years confirms, drops blood
The application of fat medicine can reduce deaths from heart disease rate 24%, reduces non-lethality heart attack rate 19%.Therefore, blood fat reducing
The research and development of medicine is increasingly subject to people's attention.Generally acknowledge that adjusting the most effective and wide variety of Western medicine of fat is him at present
Spit of fland class, but its side effect is the most notable.And from the point of view of relative to Western medicine, Chinese medicine application for the treatment of hyperlipemia more and more
In disease, and Chinese medicine lipid lowerers curative effect is affirmed, lasting, side effect is little.
Cordyceps, is that section ergot fungus cordyceps sinensis colonizes in the Stroma on Hepialidae insect larvae and larva corpse
The complex of body, is a kind of traditional famous and precious tonic Chinese medicine material, has regulation function of immune system, antitumor, resisting fatigue,
The multiple efficacies such as blood fat reducing.In pharmacology's modern study result, Cordyceps contains cordycepic acid about 7%, carbohydrate
28.9%, fat about 8.4%, protein about 25%, in fat, 82.2% is unsaturated fatty acid, additionally, it is raw still to contain dimension
Element B12, Ergota lipidol, hexose alcohol, alkaloid etc..Cordyceps has good lipid-lowering effect, it is possible to notable
Reduce triglyceride in high fat diet mouse blood, cholesterol, low-density lipoprotein cholesterol, and improve high density lipoprotein level
The content of white cholesterol.And it also is able to significantly reduce blood lipid level in stress rats and Induced by High Fat Diet in Rats blood, reduce
Erythrocyte membrane microviscosity.But, the resource scarcity of Cordyceps own, expensive, simple Cordyceps blood fat reducing
The most how limited efficacy, be used in combination Cordyceps with other Chinese medicine ingredients, improves the blood fat reducing function of Cordyceps,
It is technical problem urgently to be resolved hurrily to one skilled in the art.
Summary of the invention
It is an object of the invention to provide a kind of cordyceps sinensis composition with blood fat reducing function, the compositions of the present invention is with tool
The Cordyceps having blood fat reducing function is main component, and other Chinese medicine ingredients of compatibility is made, the worm summer in winter that fictitious hosts is expensive
Grass.
In a preferred embodiment of the present invention, the cordyceps sinensis composition of the present invention mainly comprises following crude drug
(calculated in weight percent)；Cordyceps 30-60%, Fructus Lycii 5-20%, maca powder 5-20%, Fructus Mori 5-20%,
Herba Cistanches 5-15%, Cortex Eucommiae 5-15% owner joins 3-10%, Radix Notoginseng 3-10%, Semen Euryales 2-10%.
The preparation method of the present composition specifically includes that Herba Cistanches, Radix Ginseng, Radix Notoginseng, Fructus Mori, Semen Euryales 70% ethanol
Reflux, extract, three times, and extracting solution is reduced pressure, concentrate, be dried, sieve；Fructus Lycii and Cortex Eucommiae water carry 3 times, and will
Extracting solution reduces pressure, and concentrates, and is dried, sieves.Add Cordyceps and maca powder after being mixed by extract, make 10-20
Mesh powder, loads capsule, sterilizing.
Animal experiments prove that this cordyceps sinensis composition can reduce Normal Mouse Serum positive C, LDL level, there is the relatively winter
Worm summer grass preferably effect, effectively reduces cost.
Detailed description of the invention
Embodiment 1 has the preparation of blood fat reducing function cordyceps sinensis composition
By Herba Cistanches 8 its, Radix Ginseng 5 its, Radix Notoginseng 5 its, Fructus Mori 10 its, Semen Euryales 4 its with 70% alcohol reflux three times, and
Extracting solution is reduced pressure, concentrates, be dried, sieve；Fructus Lycii 10 itself and the Cortex Eucommiae 8 its carry 3 times with water, and extracting solution is subtracted
Pressure, concentrates, and is dried, sieves.Add after extract is mixed Cordyceps 40 itself and maca powder 10 its, make 10-20
Mesh powder, load capsule, after packing in60The flat sterilizing of 5000Ra under C hundred source.
Embodiment 2 cordyceps sinensis composition blood fat reducing function
Healthy ICR mice, S also F level, male, body weight 18-22 its, animal uses prospective adaptation environment 1～2 flat, rejects not
3 groups it are randomly divided into, i.e. Cordyceps compositions group, Cordyceps group and normal group, often group 16 after qualified animal.First gavage is given
Give 200m its/(k its. flat) Cordyceps compositions 15 days, then with 100m its/(k its. flat) dosage gavage (hereinafter referred to as combines for 15 days
Thing group)；The first gavage of Cordyceps group give 250m its/(k its. flat) Cordyceps micropowder 15 days, then with 125m its/(k its. flat) dosage gavage
15 days (hereinafter referred to as Cordyceps group)；Normal group gavage give 10ml/ (k its. flat) 0.5% sodium carboxymethyl cellulose 30 days
(hereinafter referred to as normal group).After last administration, each group of mice is carried out respectively T-CHOL in serum (positive C), triglyceride
(positive G), high density lipoprotein (HDL), low density lipoprotein, LDL (LDL) measure.
The impact on normal lipid of mice of the table 1 Cordyceps composition product
Result is as shown in table 1, and in Cordyceps group serum, positive C and just C/HDL level are remarkably decreased, but align G, LDL with
The level of HDL does not affect；Cordyceps sinensis composition can reduce Normal Mouse Serum positive C, LDL and positive C/HDL level,
But G and HDL positive on normal mouse does not affect.Cordyceps compositions group is similar to Cordyceps group in the positive C level of reduction, but
It is in reduction LDL level, to be significantly higher than Cordyceps group, point out it to have certain auxiliary lipid-lowering function aspect and Cordyceps
Similar and notable reducing LDL horizontal aspect function.
It should be appreciated that the detailed description of the invention of the present invention is merely for the sake of the purpose of exemplary illustration, it is not with any
Mode limits protection scope of the present invention, and those skilled in the art can be improved according to the above description or convert, and
All these modifications and variations all should belong to the protection domain of claims of the present invention.
Claims (4)
1. the cordyceps sinensis composition of a blood fat reducing, it is characterised in that be made up of the crude drug of following weight percentage ratio: Cordyceps 30-60%, Fructus Lycii 5-20%, maca powder 5-20%, Fructus Mori 5-20%, Herba Cistanches 5-15%, Cortex Eucommiae 5-15%, Radix Ginseng 3-10%, Radix Notoginseng 3-10%, Semen Euryales 2-10%；Described compositions is made by the steps and obtains: Herba Cistanches, Radix Ginseng, Radix Notoginseng, Fructus Mori, Semen Euryales 60-80% alcohol reflux 2-4 time, and is reduced pressure by extracting solution, concentrates, is dried, sieves；Fructus Lycii and Cortex Eucommiae water carry 2-4 time, and are reduced pressure by extracting solution, concentrate, and are dried, sieve；Add Cordyceps and maca powder after being mixed by extract, make 10-20 mesh powder, load capsule, pack rear sterilizing.
2. according to the cordyceps sinensis composition described in claims 1, the crude drug wherein preparing said composition is Cordyceps 35-45%, Fructus Lycii 8-12%, maca powder 8-12%, Fructus Mori 8-12%, Herba Cistanches 6-10%, Cortex Eucommiae 6-10%, Radix Ginseng 4-6%, Radix Notoginseng 4-6%, Semen Euryales 3-5%, all crude drug component sums are 100%.
3. the application in preparing blood lipid-lowering medicine or health product of the cordyceps sinensis composition described in claim 1 or 2.
4. the application in preparation prevention and/or treatment coronary heart disease, fatty liver medicament of the cordyceps sinensis composition described in claim 1 or 2.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103892172B (en) * | 2014-03-18 | 2015-04-22 | 岳洪伟 | Nerves-calming and sleep-assisting flour and preparation method thereof |
| CN103961380A (en) * | 2014-05-28 | 2014-08-06 | 郭海涛 | Cordyceps sinensis tablet and preparation method thereof |
| CN104171153A (en) * | 2014-08-01 | 2014-12-03 | 安徽方氏中药饮片有限公司 | Maca tea and preparation method thereof |
| CN106975067A (en) * | 2017-05-25 | 2017-07-25 | 马同发 | It is a kind of can three high drop integration of drinking and medicinal herbs composition and preparation method |
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|---|---|---|---|---|
| CN1400016A (en) * | 2002-08-13 | 2003-03-05 | 马金堂 | Capsule for cleaning blood and reducing fat |
| CN101879207A (en) * | 2010-05-21 | 2010-11-10 | 郭景龙 | Pharmaceutical composition having function of reducing blood fat |
| CN102240310A (en) * | 2010-05-13 | 2011-11-16 | 郭国康 | Blood-sugar-reducing composition and preparation method thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1400016A (en) * | 2002-08-13 | 2003-03-05 | 马金堂 | Capsule for cleaning blood and reducing fat |
| CN102240310A (en) * | 2010-05-13 | 2011-11-16 | 郭国康 | Blood-sugar-reducing composition and preparation method thereof |
| CN101879207A (en) * | 2010-05-21 | 2010-11-10 | 郭景龙 | Pharmaceutical composition having function of reducing blood fat |
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| 中药降血脂作用研究进展;庄瑞丰;《河北医药》;20090531;第31卷(第9期);第1119右栏第2段及第2.1节 * |
| 玛咖醇提取物对去卵巢大鼠内分泌激素及血脂水平的影响;张永忠等;《中国新药杂志》;20081231;第17卷(第24期);摘要部分 * |
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Effective date of registration: 20170309 Address after: 810003 Qinghai science and Technology Industrial Park, Qinghai, Xining, No. three, No. 26 Patentee after: Qinghai science and Technology Co., Ltd. Address before: Hangzhou City, Zhejiang province 310000 Binjiang District West Street No. 88 Jiangling Road, building 9, room 1001 Patentee before: HANGZHOU GUOCAO BIOTECHNOLOGY CO., LTD. |
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Effective date of registration: 20180726 Address after: 817000 the Green Industrial Park of Delingha City, Haixi Mongolian and Tibetan Autonomous Prefecture, Qinghai, west of Minle Road, west of Tanggula road. Patentee after: Beijing Tongren Tang Health Pharmacy (Qinghai) Co., Ltd. Address before: 810003 Qinghai biological science and Technology Industrial Park, Xining, Qinghai, No. 26, No. three road. Patentee before: Qinghai science and Technology Co., Ltd. |
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