CN103550864A - Hybrid-driven pacemaker and hybrid driving method of pacemaker electrode - Google Patents

Hybrid-driven pacemaker and hybrid driving method of pacemaker electrode Download PDF

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Publication number
CN103550864A
CN103550864A CN201310520450.9A CN201310520450A CN103550864A CN 103550864 A CN103550864 A CN 103550864A CN 201310520450 A CN201310520450 A CN 201310520450A CN 103550864 A CN103550864 A CN 103550864A
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pacemaker
electrode
super capacitor
decision circuitry
thin film
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CN103550864B (en
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李舟
石波璟
王中林
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Beijing Institute of Nanoenergy and Nanosystems
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National Center for Nanosccience and Technology China
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Abstract

The invention discloses a hybrid-driven pacemaker and a hybrid driving method of a pacemaker electrode. According to the hybrid-driven pacemaker, mechanical energy generated by the contraction and release of an organ is converted into electric energy through a nanogenerator, the hybrid-driven pacemaker is attached to the organ, the electric energy is stored in a super capacitor, and when the pacemaker electrode needs to work, the pacemaker electrode is driven to work under the control of a control module. A battery module only supplies a power supply to the pacemaker electrode when power in the super capacitor is insufficient. Correspondingly, the hybrid driving method of the pacemaker electrode is further provided. According to the pacemaker, the service life of the battery module is greatly prolonged, and reoperation risks and economic loads caused by battery replacement to a patient are lowered.

Description

A kind of method of pacemaker of combination drive and combination drive pacemaker electrode
Technical field
The present invention relates to medical instruments field, be specifically related to a kind of pacemaker based on nano generator combining super capacitor device and rechargeable battery combination drive and the method for combination drive pacemaker electrode.
Background technology
Pacemaker, also claims pulse generator.The pacemaker that people are usually said, refers to whole pacing system.Pacing system is comprised of pacemaker, pacing electrode wire and program control instrument, wherein pacemaker and pacing electrode wire implant into body.Pacemaker is comprised of the circuit and the battery that are arranged in can.Pacemaker mainly can be divided into cardiac pacemaker, brain pacemaker, larynx pacemaker etc. at present.
Existing cardiac pacemaker, brain pacemaker, larynx pacemaker etc. all need to implant, and need battery to power.At present, the battery in pacemaker is generally the lithium-iodine battery being enclosed in titanium alloy casing, and when battery electric quantity exhausts, needs of patients performs the operation to change battery again could continue to use pacemaker, has caused great burden to patient's body and mind and economy.
Summary of the invention
The invention provides a kind of pacemaker of the combination drive with nano generator combining super capacitor and rechargeable battery, in order to solve current pacemaker battery limited problem in cruising time.
To achieve these goals, the invention provides a kind of pacemaker of combination drive, comprising: nano generator, rectification circuit, super capacitor, control module, battery module and pacemaker electrode, wherein,
The mechanical force that described nano generator produces for collecting organ, and produce the alternating-current pulse signal of telecommunication;
Described rectification circuit changes DC signal into for the signal of telecommunication that described nano generator is produced, the DC pulse signal of telecommunication that super capacitor produces for storing described rectification circuit;
Described control module is for occurring in the current potential information of pacemaker therapentic part when abnormal, and super capacitor drives described pacemaker electrode to discharge to pacemaker therapentic part described in instruction; When the electric weight in super capacitor is not enough to drive pacemaker electrode electric discharge, described control module drives pacemaker electrode electric discharge for instruction battery module.
Preferably, when described pacemaker electrode does not discharge, described control module is used for instruction super capacitor to described charging battery module.
Preferably, described control module comprises the first decision circuitry, filter circuit and mu balanced circuit, wherein,
Described the first decision circuitry, for accepting the pacemaker therapentic part current potential information of pacemaker electrode feedback and judging whether extremely, occurs that in current potential information when abnormal, instruction super capacitor output electric energy is given described filter circuit; Described the first decision circuitry is also for judging whether the electric weight of described super capacitor can drive pacemaker electrode electric discharge, when the electric weight in super capacitor is not enough to drive pacemaker electrode 6 electric discharge, described the first decision circuitry drives pacemaker electrode for battery module described in instruction; The electric quantity signal that described the first decision circuitry is also sent for receiving battery module, the electric weight in battery module when setting limit value, described the first decision circuitry for instruction super capacitor to described charging battery module;
Described filter circuit is for carrying out filtering by the Rectified alternating current of described super capacitor output;
Described mu balanced circuit is for discharging to pacemaker therapentic part offering pacemaker electrode after the further voltage stabilizing of unidirectional current of described filter circuit output.
Preferably, described the first decision circuitry comprises: central processor CPU, memory RAM and A/D converter, wherein,
The signal input port of described the first decision circuitry is exported instruction according to judged result after receiving and being transferred to central processor CPU and memory RAM after signal storing and judge after A/D converter is processed by signal outlet.
Preferably, described battery module comprises the second decision circuitry and rechargeable battery, and wherein, the effect of the second decision circuitry is to judge that whether electric weight in rechargeable battery is lower than described setting limit value; The effect of the second decision circuitry is also to receive the instruction that the first decision circuitry provides, and rechargeable battery is discharged or charged.
Preferably, described the second decision circuitry comprises: central processor CPU, memory RAM and A/D converter, wherein,
The signal input port of described the second decision circuitry is exported instruction according to judged result after receiving and being transferred to central processor CPU and memory RAM after signal storing and judge after A/D converter is processed by signal outlet.
Preferably, described nano generator is franklinic electricity nano generator.
Preferably, described franklinic electricity nano generator comprises: the first electrode, polymeric dielectric layer, metal nanoparticle and the second electrode, wherein, the first electrode contact is arranged at the upper surface of polymeric dielectric layer, metal nanoparticle is attached to the upper surface of the second electrode, and the lower surface of polymeric dielectric layer and the second electrodes have the surface of metal nanoparticle to be oppositely arranged; When franklinic electricity nano generator generation deformation, described polymeric dielectric layer lower surface and described gold nano grain rub.
Preferably, described polymeric dielectric layer is selected from politef, polydimethylsiloxane, Kapton, aniline-formaldehyde resin thin film, polyformaldehyde thin film, ethyl cellulose film, polyamide film, melamino-formaldehyde thin film, Polyethylene Glycol succinate thin film, cellulose membrane, cellulose acetate film, 10PE27 thin film, polydiallyl phthalate thin film, regenerated fiber sponge thin film, elastic polyurethane body thin film, styrene-acrylonitrile copolymer copolymer film, styrene-butadiene-copolymer thin film, staple fibre thin film, poly-methyl thin film, methacrylic acid ester film, polyvinyl alcohol film, mylar, polyisobutylene thin film, polyurethane flexible sponge thin film, pet film, polyvinyl butyral film, phenolic resins thin film, neoprene thin film, butadiene-propylene copolymer thin film, natural rubber thin film, polyacrylonitrile thin film, poly-(vinylidene chloride-co-acrylonitrile) thin film or polyethylene the third diphenol carbonate thin film, polystyrene, polymethyl methacrylate, Merlon or polymeric liquid crystal copolymer, polychlorobutadiene, polyacrylonitrile, poly-biphenol carbonic ester, CPPG, polyvinylidene chloride, polyethylene, polypropylene and polrvinyl chloride.
Preferably, described the first electrode and/or the second electrode are metallic film.
Preferably, described metal nanoparticle is gold nano grain.
Preferably, described nano generator is piezoelectric type nano generator, and described piezoelectric type nano generator comprises top electrode, dielectric layer, piezoelectric layer and the hearth electrode of stacked close contact from top to bottom.
Preferably, described piezoelectric type nano generator is flexible structure.
Preferably, described piezoelectric layer is piezoelectric membrane or piezoelectric nano structural material.
Preferably, described super capacitor is carbon nano-tube super electric capacity.
Accordingly, the present invention also provides the method for a kind combination drive pacemaker electrode to comprise step:
Nano generator is provided;
Described nano generator is subject to the effect generation deformation of power, produces ac signal; The effect of described power is from the motion of the attached organ of described nano generator note;
Described ac signal is stored in super capacitor after rectification circuit rectification is DC signal;
The current potential information of pacemaker electrode perception pacemaker therapentic part, and described current potential information is fed back to control module;
Described control module judges that whether described current potential information is normal, if normal, pacemaker electrode does not discharge; If undesired, whether the electric weight of control module test super capacitor can drive pacemaker electrode electric discharge, and if so, the electric energy in control module instruction super capacitor drives pacemaker electrode electric discharge; If not, the electric energy in control module instruction battery module drives pacemaker electrode electric discharge.
Preferably, described control module comprises the first decision circuitry, filter circuit and mu balanced circuit, and described control module judges that whether described current potential information is normal, is specially, and described the first decision circuitry judges that whether described current potential information is normal;
Whether the electric weight of control module test super capacitor can drive pacemaker electrode electric discharge, is specially, and whether the electric weight of the first decision circuitry test super capacitor can drive pacemaker electrode electric discharge;
Control module instruction super capacitor or battery module drive pacemaker electrode electric discharge, are specially, and the electric energy in the first decision circuitry instruction super capacitor or battery module offers pacemaker electrode electric discharge after circuit and mu balanced circuit after filtering.
Preferably, also comprise step: the electric energy in battery module is when setting limit value, and the electric energy transmitting storing in super capacitor described in control module instruction is to battery module.
Preferably, described battery module comprises the second decision circuitry and rechargeable battery, and wherein, under the instruction of described the first decision circuitry, the second decision circuitry is controlled described rechargeable battery and discharged to pacemaker electrode.
Preferably, the span of described setting limit value is the 50%-95% of described battery module Full Charge Capacity.
The pacemaker of combination drive provided by the invention, compared with prior art has following advantages:
In the present invention, the mechanical energy producing while transforming the attached organ of its note (as heart or diaphram) folding and unfolding by nano generator is electric energy and is stored in super capacitor, drives pacemaker electrode work when pacemaker electrode need to be worked under the control of control module; Battery module when only the electric weight in super capacitor is not enough for pacemaker electrode provides power supply.The pacemaker of relatively traditional lithium-iodine battery power supply, adopt pacemaker and the pacemaker electrode driving method of combination drive of the present invention, greatly extended the service life of battery module, reduced and changed risk and the financial burden of operation again that battery brings to patient.
In addition, by the control of control module, super capacitor can also be charging battery module, can further extend the service life of battery module.
Accompanying drawing explanation
Accompanying drawing is to be used to provide a further understanding of the present invention, and forms a part for description, is used from explanation the present invention, but is not construed as limiting the invention with the specific embodiment one below.In the accompanying drawings:
Fig. 1 is the structural representation of combination drive pacemaker of the present invention;
Fig. 2 is the structural representation of control module in combination drive pacemaker of the present invention;
Fig. 3 is the structural representation of battery module in combination drive pacemaker of the present invention;
Fig. 4-6 are the structural representation of franklinic electricity nano generator in combination drive pacemaker of the present invention;
Fig. 7 is the structural representation of piezoelectric type nano generator in combination drive pacemaker of the present invention;
Fig. 8 is the schematic diagram of the first decision circuitry in control module;
Fig. 9 is the schematic diagram of combination drive pacemaker electrode method of the present invention.
The specific embodiment
For making the object, technical solutions and advantages of the present invention clearer, below in conjunction with specific embodiment, and with reference to accompanying drawing, the present invention is described in further detail.
The invention provides a kind of pacemaker of combination drive, can solve in prior art, pacemaker can only rely on battery powered, causes service life limited and need to change the problems such as battery.
Fig. 1 shows the structural representation of combination drive pacemaker provided by the invention, and this pacemaker comprises: nano generator 1, rectification circuit 2, super capacitor 3, control module 4, battery module 5 and pacemaker electrode 6.
Wherein, the mechanical force that nano generator 1 produces for collecting organ, and produce the alternating-current pulse signal of telecommunication.
Rectification circuit 2 changes DC signal into for the signal of telecommunication that nano generator 1 is produced, the DC pulse signal of telecommunication that super capacitor 3 produces for storing rectification circuit 2.
Control module 4 occurs when abnormal for the current potential information at pacemaker therapentic part, and instruction super capacitor drives pacemaker electrode 6 to discharge to pacemaker therapentic part; When the electric weight in super capacitor is not enough to drive pacemaker electrode 6 electric discharge, for instruction battery module 5, drive pacemaker electrode 6.
When pacemaker electrode 6 does not discharge, instruction super capacitor 3 can be to battery module 5 chargings.
Pacemaker therapentic part described in the present invention, is specially and needs pacemaker to carry out the position of electric pulse stimulation, organs such as heart, brain, nerve.
As an embodiment, referring to Fig. 2, control module 4 can comprise the first decision circuitry 7, filter circuit 8 and mu balanced circuit 9.Wherein, the first decision circuitry 7, for accepting the pacemaker therapentic part current potential information of pacemaker electrode 6 feedback and judging whether extremely, occurs that in current potential information when abnormal, instruction super capacitor 3 output electric energy are to filter circuit 8; The first decision circuitry 7 is also for judging whether the electric weight of super capacitor 3 can drive pacemaker electrode 6 electric discharges, when the electric weight in super capacitor 3 is not enough to drive pacemaker electrode 6 electric discharge, the first decision circuitry 7 drives pacemaker electrode 6 for instruction battery module; The electric quantity signal that the first decision circuitry 7 is also sent for receiving battery module, the electric weight in battery module is when setting limit value, and the first decision circuitry 7 is for 5 chargings of 3 pairs of battery modules of instruction super capacitor.Filter circuit 8 is for carrying out filtering by the Rectified alternating current of super capacitor 3 outputs; Mu balanced circuit 9 is for discharging to pacemaker therapentic part offering pacemaker electrode 6 after the further voltage stabilizing of unidirectional current of filter circuit 8 outputs.
Pacemaker of the present invention, the electric weight in battery module is when setting limit value, and control module can instruction super capacitor be charging battery module.Described setting limit value is the charge capacity limit value of in advance battery module 5 being set, the electric weight in battery module during lower than this limit value to charging battery module, during higher than this limit value not to charging battery module.The span of described setting limit value can be the 50%-95% of battery module 5 Full Charge Capacities.
As an embodiment, referring to Fig. 3, battery module 5 can comprise the second decision circuitry 10 and rechargeable battery 11.Wherein, the effect of the second decision circuitry 10 is to judge that whether electric weight in rechargeable battery 11 is lower than described setting limit value; The effect of the second decision circuitry 10 is also to receive the instruction that the first decision circuitry 7 provides, and rechargeable battery 11 is discharged or charged.When pacemaker electrode 6 needs electric discharge and the electric energy that stores in super capacitor 3 when not enough, the instruction that the second decision circuitry 10 is accepted the first decision circuitry 7 in control module makes rechargeable battery 11 provide driving electric energy to pacemaker electrode 6; When pacemaker electrode 6 does not need electric discharge, and in rechargeable battery 11, electric weight is when setting limit value, and the instruction that the second decision circuitry 10 is accepted the first decision circuitry 7 in control module makes super capacitor 3 for rechargeable battery 11 chargings.
Introduce the structure of each several part in combination drive pacemaker of the present invention below.
Nano generator 1 can be designed to laminated structure, after coated with biocompatible materials, note is attached to heart, diaphram etc. and can produces on the organ of motion, drives nano generator 1 that deformation occurs and impel between two electrodes of nano generator to produce the output of the alternating-current pulse signal of telecommunication when the organ normal operations such as heart, diaphram.
Nano generator 1 can be franklinic electricity nano generator, and the structure of franklinic electricity nano generator, referring to Fig. 4, comprising: the first electrode 13, polymeric dielectric layer 14, metal nanoparticle 15 and the second electrode 16.Concrete, the first electrode 13 contacts are arranged at the upper surface 14a of polymeric dielectric layer 14.The metallic film that the first electrode 13 and the second electrode 16 are conduction, preferred, be gold thin film, the first electrode 13 can be plated on the lower surface 14a of described polymeric dielectric layer 14 by vacuum sputtering and vapour deposition method.Metal nanoparticle 15 is attached to the upper surface of the second electrode 16, and the surface that the lower surface 14b of polymeric dielectric layer 14 and the second electrode 16 are attached with metal nanoparticle is oppositely arranged, and wherein, metal nanoparticle, is preferably gold nano grain.
Polymeric dielectric layer 14 can be politef, polydimethylsiloxane, Kapton, aniline-formaldehyde resin thin film, polyformaldehyde thin film, ethyl cellulose film, polyamide film, melamino-formaldehyde thin film, Polyethylene Glycol succinate thin film, cellulose membrane, cellulose acetate film, 10PE27 thin film, polydiallyl phthalate thin film, regenerated fiber sponge thin film, elastic polyurethane body thin film, styrene-acrylonitrile copolymer copolymer film, styrene-butadiene-copolymer thin film, staple fibre thin film, poly-methyl thin film, methacrylic acid ester film, polyvinyl alcohol film, mylar, polyisobutylene thin film, polyurethane flexible sponge thin film, pet film, polyvinyl butyral film, phenolic resins thin film, neoprene thin film, butadiene-propylene copolymer thin film, natural rubber thin film, polyacrylonitrile thin film, poly-(vinylidene chloride-co-acrylonitrile) thin film or polyethylene the third diphenol carbonate thin film, polystyrene, polymethyl methacrylate, Merlon or polymeric liquid crystal copolymer, polychlorobutadiene, polyacrylonitrile, poly-biphenol carbonic ester, CPPG, polyvinylidene chloride, polyethylene, polypropylene and polrvinyl chloride etc.
Franklinic electricity nano generator is encapsulated to rear note and be attached to the organ surfaces such as heart, diaphram, when organ diastole, drive the deformation such as franklinic electricity nano generator bends, schematic cross-section when Fig. 5 shows the bending of franklinic electricity nano generator, when franklinic electricity nano generator bends, can there is friction with the surface of polymeric dielectric layer 14 and produce electrostatic charge in gold nano grain 15, the generation of electrostatic charge can make the electric capacity between the first electrode 13 and the second electrode 16 change, thereby makes to occur electric potential difference between the first electrode 13 and the second electrode 16.
Fig. 6 shows the schematic diagram that in the preferred embodiment of the present invention, franklinic electricity nano generator is connected with external circuit, between two electrodes of franklinic electricity nano generator, connects an ammeter 17, with the external circuit that represents that nano generator connects.
When the electric potential difference shown in Fig. 5 occurs, free electron by by external circuit by the low lateral electrode of electromotive force the second electrode 16 flow to i.e. the first electrode 13 of electrode that electromotive force is high, thereby at external circuit, form electric current, in ammeter 17, have electric current to flow through.When nano generator is returned to the state as Fig. 4 from case of bending, at this moment the built-in potential between the first electrode 13 and the second electrode 16 disappears, insulation characterisitic due to whole franklinic electricity generator polymeric dielectric layer 14, can prevent that free electron is in the inner neutralization of franklinic electricity nano generator, now between Balanced the first electrode 13 and the second electrode 16, will again produce reverse potential difference, free electron is got back to i.e. the second electrode 16 of an original lateral electrode by external circuit from the first electrode 13, thereby in external circuit, forms reverse current.The operation principle of Here it is franklinic electricity nano generator.
Nano generator also can adopt piezoelectric type nano generator, and the typical structure of piezoelectric type nano generator, referring to Fig. 7, comprises top electrode 23, dielectric layer 24, piezoelectric layer 25 and the hearth electrode 26 of stacked close contact from top to bottom.Top electrode 23 and hearth electrode 24 are preferably thin-film material, can select conventional electrode material, for example, can be selected from metal, conductive oxide and conducting polymer.Metal can be selected from gold, silver, platinum, aluminum, nickel, copper, titanium, chromium or selenium, and the alloy being formed by above-mentioned metal.The material of piezoelectric layer 25 can be polymer, as PMMA(polymethyl methacrylate), PI(pi), PET(polyethylene terephthalate), PS(polystyrene) etc.The material of piezoelectric layer 25 can be any piezoelectric membrane or piezoelectric nano structural material, for example: ZnO, Pb (Zr, Ti) O 3, BaTiO 3, GaN etc. thin film, nano wire or nanometer rods etc., be preferably the nano wire of the wurtzite structure piezoelectrics such as ZnO, GaN, piezoelectric layer 25 is ZnO nanowire array more preferably, the two ends of described nano wire are connected with hearth electrode 26 with piezoelectric layer 25 respectively.
Piezoelectric type nano generator is preferably flexible structure, piezoelectric type nano generator encapsulates rear note and is attached to heart, the organ surfaces such as diaphram, when organ diastole, drive franklinic electricity nano generator to bend and piezoelectric layer 25 is exerted pressure while making it that deformation occur, piezoelectric layer 25 is inner can produce a corresponding piezoelectric field by strain, this piezoelectric field can make the surface of top electrode and hearth electrode produce electric potential difference, and then drive the electronics of external circuit from one end electrode stream to other end electrode, thereby formation electric current, until the electronics of accumulating on electrode and piezoelectric field reach balance, and when applied stress unloads, the electric potential difference being formed by piezoelectric field disappears, the electrons accumulating on one of them electrode is flowed back to by rightabout, has so just formed the current signal of an interchange.
In the present invention, rectification circuit 2 changes direct current signal into for the alternating-current pulse signal of telecommunication that nano generator is produced, and can be bridge rectifier.Super capacitor 3, for storing from the DC signal of rectification circuit 2 outputs, is preferably carbon nano-tube super electric capacity.Pacemaker electrode is a pulse generator, under control module is controlled by the electric energy transmitting in super capacitor or battery module to pulse generator, to pacemaker therapentic part, apply electric pulse.Pacemaker electrode 6 can also have the function of surveying pacemaker therapentic part current potential information and feeding back to control module 4.
Referring to Fig. 8, in control module 4, the first decision circuitry 7 can comprise central processor CPU, memory RAM and A/D converter, the signal input port In of the first decision circuitry exports instruction according to judged result after receiving and being transferred to central processor CPU and memory RAM after signal storing and judge after A/D converter is processed by signal outlet Out.The signal that signal input port In receives comprises: pacemaker therapentic part current potential information, the information about power of super capacitor and the information about power of battery module that pacemaker electrode returns.The signal of signal outlet Out output comprises: whether to pacemaker electrode electric discharge, select super capacitor or battery module to pacemaker electrode electric discharge and super capacitor to charging battery module.The realization of the concrete function of the first decision circuitry 7 can realize by write-in program in central processor CPU, memory RAM and A/D converter.
Particularly, filter circuit 8 and mu balanced circuit 9 are common circuit, and physical circuit and parameter can reasonably design as required.
In battery module 5, the second decision circuitry 10 is connected between the first decision circuitry and rechargeable battery, for controlling rechargeable battery 11, to pacemaker electrode 6, discharges electric energy; Can also be for judging whether the electric weight of rechargeable battery 11 is less than setting limit value, if be less than setting limit value, the second decision circuitry 10 is controlled 3 pairs of rechargeable batteries 11 of super capacitor and is charged.In battery module 5, the second decision circuitry 10 can be identical with the first decision circuitry 7 structures, the second decision circuitry 10 can comprise central processor CPU, memory RAM and A/D converter, referring to Fig. 8, the signal input port In of the second decision circuitry exports instruction according to judged result after receiving and being transferred to central processor CPU and memory RAM after signal storing and judge after A/D converter is processed by signal outlet Out.The signal that signal input port In receives comprises: the charging instruction of control module 4 or electric discharge instruction.The signal of signal outlet Out output comprises: electric quantity of rechargeable battery signal; Whether rechargeable battery discharges or charging signals.The realization of the concrete function of the second decision circuitry 10 can realize by write-in program in central processor CPU, memory RAM and A/D converter.Rechargeable battery 11 is preferably lithium ion battery.
Conventional pacemaker can be divided into cardiac pacemaker, brain pacemaker, larynx pacemaker etc.Cardiac pacemaker is a kind ofly by the Pacing lead contacting with heart, to transmit electricity irritation, finally cause whole atrium (or) device of ventricular systole, can be used for treating that acute and chronic arrhythmia, neural mediation are fainted, the disease such as obstructive heart disease and obstinate type heart failure.Brain pacemaker, claim again brain deep brain stimulation device, specific nerve nucleus implant electrode in brain, discharge high-frequency electrical stimulation, lower that pathological changes is neuronic is overexcited, suppress to cause the abnormal brain nerve signal of parkinson disease symptom, thereby alleviate Parkinsonian cardinal symptom: tremble, stiff and bradykinesia, especially center line symptom has good improvement effect, as started to walk and standing up difficulty etc.Larynx pacemaker, its main part is a pulse generator, this implantable pulse generator can make the patient of laryngeal muscles bilateral paralysis speak normally and breathe.No matter which kind of pacemaker, all need to carry out electricity irritation to pacemaker therapentic part at power drives pulse generator, in existing pacemaker, adopts lithium ion battery as power supply, with pulse generator, control device and pacemaker electrode together in implantable bioartificial body.Because the electric weight of lithium ion battery is limited, when battery electric quantity is not enough to drive pacemaker electrode, pacemaker cisco unity malfunction, to patient's health even life cause great threat, need to again perform the operation and carry out battery altering, not only to patient, cause financial burden, and can affect patient's physical and mental health.
Adopt the pacemaker of combination drive of the present invention, mainly utilized nano generator to collect the contraction of patient's organ such as heart etc. and the energy of diastole, changed into electric energy and drive pacemaker electrode.This pacemaker also comprises battery module simultaneously, and as stand-by power supply, when the electric weight storing in super capacitor is not enough to drive pacemaker electrode, battery module will be as power drives pacemaker electrode.The use of the pacemaker of combination drive of the present invention has solved the problem that existing pacemaker need to be changed battery, work that can be for a long time stable.
Cardiac pacemaker take below as example, in conjunction with Fig. 1, specifically introduce the work process of the pacemaker of combination drive of the present invention, generation current after the mechanical energy when nano generator 1 is subject to as heart beating or contraction of diaphragm and diastole.Because the electric current producing is like this alternating current, the alternating current that therefore by rectification circuit 2, nano generator 1 is produced becomes unidirectional current.By the electric current after rectification, super capacitor 3 is charged.When delaying or overrunning appearred in patient's heart beating, pacemaker is started working, and now super capacitor 3, to pacemaker electrode 6 input electric energy, drives its work; When patient's heart beating is normal, the sensor feedback signal in pacemaker electrode 6, to control module 4, is controlled super capacitor 3 and is made super capacitor 3 to pacemaker electrode 6, not provide electric energy, but charge to battery module 5 by control module 4.When pacemaker long period work and the stored energy of super capacitor 3 temporarily cannot meet pacemaker time, control module 4 instruction battery modules 5 are started working and are provided electric energy to pacemaker electrode 6, thereby have guaranteed that the heart device of fighting can work long hours.
No matter nano generator 1 adopts piezoelectric type nano generator or franklinic electricity nano generator, and preferred, nano generator is flexible device.Particularly franklinic electricity nano generator can adopt high molecular polymer to make, and making nano generator whole is flexible structure.Flexible nano generator 1 is attached to heart or diaphram surface, utilize the diastole of heart or diaphram to change and make nano generator that corresponding bending change occur along with the variation of heart with the heart surface curvature of shrinking generation, thereby the two electrodes generation electric potential differences at electromotor drive free electron to flow in peripheral circuit, then through rectification circuit, change the applicable electric current that can charge to energy-storage travelling wave tube into, or drive the work of cardiac pacemaker electrode.Brain pacemaker is identical with the operation principle of cardiac pacemaker with the operation principle of larynx pacemaker.
Accordingly, the present invention also provides a kind of method of combination drive pacemaker electrode, and flow chart shown in Figure 9, comprises step:
Nano generator is provided;
Described nano generator is subject to the effect generation deformation of power, produces ac signal AC; The effect of described power is from the motion of the attached organ of described nano generator note;
Described ac signal AC is stored in super capacitor after rectification circuit rectification is DC signal DC;
The current potential information EF of pacemaker electrode perception pacemaker therapentic part, and described current potential information EF is fed back to control module;
Described control module judges that whether described current potential information EF is normal, if normal, pacemaker electrode does not discharge; If undesired, whether the electric weight of control module test super capacitor can drive pacemaker electrode electric discharge, and if so, the electric energy Q(in control module instruction super capacitor provides electric current I) drive pacemaker electrode to discharge; If not, the electric energy Q-out(in control module instruction battery module provides electric current I) drive pacemaker electrode to discharge.
The method of combination drive pacemaker electrode provided by the invention, the main raw energy of nano generator catcher official career movable property that relies on is changed into electrical power storage in ultracapacitor, for pacemaker electrode provides power supply, when the electric weight in super capacitor is not enough to drive pacemaker electrode, battery module provides power supply for pacemaker electrode, realizes combination drive pacemaker electrode.Method advantage of the present invention is, mainly relies on the electrical power storage that nano generator produces and powers in super capacitor, and battery module supplementing when the electric weight of super capacitor is not enough just, therefore, battery module can be used for a long time.
Preferably, also comprise step: the electric energy in battery module is when setting limit value, and the electric energy Q storing in super capacitor described in control module instruction is transferred to battery module.This step makes battery module obtain electric energy from super capacitor, further extends the life-span of battery module.The span of described setting limit value can be the 50%-95% of battery module 5 Full Charge Capacities.
Preferably, control module comprises the first decision circuitry, filter circuit and mu balanced circuit, and described control module judges that whether described current potential information is normal, is specially, and described the first decision circuitry judges that whether described current potential information is normal.Whether the electric weight of control module test super capacitor can drive pacemaker electrode electric discharge, is specially, and whether the electric weight of the first decision circuitry test super capacitor can drive pacemaker electrode electric discharge.Control module instruction super capacitor or battery module drive pacemaker electrode electric discharge, are specially, and the electric energy in the first decision circuitry instruction super capacitor or battery module offers pacemaker electrode electric discharge after circuit and mu balanced circuit after filtering.Control module instruction battery module drives pacemaker electrode electric discharge, is specially, and described the first decision circuitry instruction battery module drives pacemaker electrode electric discharge.
Preferably, described battery module comprises the second decision circuitry and rechargeable battery.Wherein, under the instruction of described the first decision circuitry, the second decision circuitry is controlled described rechargeable battery and is discharged to pacemaker electrode.
Preferably, under the instruction of described the first decision circuitry, the second decision circuitry is tested the whether satisfied limit value of setting of electric weight of described rechargeable battery, do not meet while setting limit value, the second decision circuitry is returned to the request that needs charging to the first decision circuitry, the electric energy transmitting storing in super capacitor described in described the first decision circuitry instruction is to described rechargeable battery.
Above-described specific embodiment; object of the present invention, technical scheme and beneficial effect are further described; be understood that; the foregoing is only specific embodiments of the invention; be not limited to the present invention; within the spirit and principles in the present invention all, any modification of making, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.

Claims (20)

1. a pacemaker for combination drive, is characterized in that, comprising: nano generator, rectification circuit, super capacitor, control module, battery module and pacemaker electrode, wherein,
The mechanical force that described nano generator produces for collecting organ, and produce the alternating-current pulse signal of telecommunication;
Described rectification circuit changes DC signal into for the signal of telecommunication that described nano generator is produced, the DC pulse signal of telecommunication that super capacitor produces for storing described rectification circuit;
Described control module is for occurring in the current potential information of pacemaker therapentic part when abnormal, and super capacitor drives described pacemaker electrode to discharge to pacemaker therapentic part described in instruction; When the electric weight in super capacitor is not enough to drive pacemaker electrode electric discharge, described control module drives pacemaker electrode electric discharge for instruction battery module.
2. pacemaker according to claim 1, is characterized in that, when described pacemaker electrode does not discharge, described control module is used for instruction super capacitor to described charging battery module.
3. pacemaker according to claim 1 and 2, is characterized in that, described control module comprises the first decision circuitry, filter circuit and mu balanced circuit, wherein,
Described the first decision circuitry, for accepting the pacemaker therapentic part current potential information of pacemaker electrode feedback and judging whether extremely, occurs that in current potential information when abnormal, instruction super capacitor output electric energy is given described filter circuit; Described the first decision circuitry is also for judging whether the electric weight of described super capacitor can drive pacemaker electrode electric discharge, when the electric weight in super capacitor is not enough to drive pacemaker electrode 6 electric discharge, described the first decision circuitry drives pacemaker electrode for battery module described in instruction; The electric quantity signal that described the first decision circuitry is also sent for receiving battery module, the electric weight in battery module when setting limit value, described the first decision circuitry for instruction super capacitor to described charging battery module;
Described filter circuit is for carrying out filtering by the Rectified alternating current of described super capacitor output;
Described mu balanced circuit is for discharging to pacemaker therapentic part offering pacemaker electrode after the further voltage stabilizing of unidirectional current of described filter circuit output.
4. pacemaker according to claim 3, is characterized in that, described the first decision circuitry comprises: central processor CPU, memory RAM and A/D converter, wherein,
The signal input port of described the first decision circuitry is exported instruction according to judged result after receiving and being transferred to central processor CPU and memory RAM after signal storing and judge after A/D converter is processed by signal outlet.
5. according to the pacemaker described in claim 3 or 4, it is characterized in that, described battery module comprises the second decision circuitry and rechargeable battery, and wherein, the effect of the second decision circuitry is to judge that whether electric weight in rechargeable battery is lower than described setting limit value; The effect of the second decision circuitry is also to receive the instruction that the first decision circuitry provides, and rechargeable battery is discharged or charged.
6. pacemaker according to claim 5, is characterized in that, described the second decision circuitry comprises: central processor CPU, memory RAM and A/D converter, wherein,
The signal input port of described the second decision circuitry is exported instruction according to judged result after receiving and being transferred to central processor CPU and memory RAM after signal storing and judge after A/D converter is processed by signal outlet.
7. according to the pacemaker described in claim 1-6 any one, it is characterized in that, described nano generator is franklinic electricity nano generator.
8. pacemaker according to claim 7, it is characterized in that, described franklinic electricity nano generator comprises: the first electrode, polymeric dielectric layer, metal nanoparticle and the second electrode, wherein, the first electrode contact is arranged at the upper surface of polymeric dielectric layer, metal nanoparticle is attached to the upper surface of the second electrode, and the lower surface of polymeric dielectric layer and the second electrodes have the surface of metal nanoparticle to be oppositely arranged; When franklinic electricity nano generator generation deformation, described polymeric dielectric layer lower surface and described gold nano grain rub.
9. pacemaker according to claim 8, is characterized in that, described polymeric dielectric layer is selected from politef, polydimethylsiloxane, Kapton, aniline-formaldehyde resin thin film, polyformaldehyde thin film, ethyl cellulose film, polyamide film, melamino-formaldehyde thin film, Polyethylene Glycol succinate thin film, cellulose membrane, cellulose acetate film, 10PE27 thin film, polydiallyl phthalate thin film, regenerated fiber sponge thin film, elastic polyurethane body thin film, styrene-acrylonitrile copolymer copolymer film, styrene-butadiene-copolymer thin film, staple fibre thin film, poly-methyl thin film, methacrylic acid ester film, polyvinyl alcohol film, mylar, polyisobutylene thin film, polyurethane flexible sponge thin film, pet film, polyvinyl butyral film, phenolic resins thin film, neoprene thin film, butadiene-propylene copolymer thin film, natural rubber thin film, polyacrylonitrile thin film, poly-(vinylidene chloride-co-acrylonitrile) thin film or polyethylene the third diphenol carbonate thin film, polystyrene, polymethyl methacrylate, Merlon or polymeric liquid crystal copolymer, polychlorobutadiene, polyacrylonitrile, poly-biphenol carbonic ester, CPPG, polyvinylidene chloride, polyethylene, polypropylene and polrvinyl chloride.
10. pacemaker according to claim 8 or claim 9, is characterized in that, described the first electrode and/or the second electrode are metallic film.
11. pacemakers according to claim 8, is characterized in that, described metal nanoparticle is gold nano grain.
12. according to the pacemaker described in claim 1-6 any one, it is characterized in that, described nano generator is piezoelectric type nano generator, and described piezoelectric type nano generator comprises top electrode, dielectric layer, piezoelectric layer and the hearth electrode of stacked close contact from top to bottom.
13. pacemakers according to claim 12, is characterized in that, described piezoelectric type nano generator is flexible structure.
14. according to the pacemaker described in claim 12 or 13, it is characterized in that, described piezoelectric layer is piezoelectric membrane or piezoelectric nano structural material.
15. according to the pacemaker described in claim 1-14 any one, it is characterized in that, described super capacitor is carbon nano-tube super electric capacity.
The method of 16. 1 kinds of combination drive pacemaker electrodes, is characterized in that, comprises step:
Nano generator is provided;
Described nano generator is subject to the effect generation deformation of power, produces ac signal; The effect of described power is from the motion of the attached organ of described nano generator note;
Described ac signal is stored in super capacitor after rectification circuit rectification is DC signal;
The current potential information of pacemaker electrode perception pacemaker therapentic part, and described current potential information is fed back to control module;
Described control module judges that whether described current potential information is normal, if normal, pacemaker electrode does not discharge; If undesired, whether the electric weight of control module test super capacitor can drive pacemaker electrode electric discharge, and if so, the electric energy in control module instruction super capacitor drives pacemaker electrode electric discharge; If not, the electric energy in control module instruction battery module drives pacemaker electrode electric discharge.
17. methods according to claim 16, it is characterized in that, described control module comprises the first decision circuitry, filter circuit and mu balanced circuit, and described control module judges that whether described current potential information is normal, be specially, described the first decision circuitry judges that whether described current potential information is normal;
Whether the electric weight of control module test super capacitor can drive pacemaker electrode electric discharge, is specially, and whether the electric weight of the first decision circuitry test super capacitor can drive pacemaker electrode electric discharge;
Control module instruction super capacitor or battery module drive pacemaker electrode electric discharge, are specially, and the electric energy in the first decision circuitry instruction super capacitor or battery module offers pacemaker electrode electric discharge after circuit and mu balanced circuit after filtering.
18. according to the method described in claim 16 or 17, it is characterized in that, also comprises step: the electric energy in battery module is when setting limit value, and the electric energy transmitting storing in super capacitor described in control module instruction is to battery module.
19. methods according to claim 18, is characterized in that, described battery module comprises the second decision circuitry and rechargeable battery, and wherein, under the instruction of described the first decision circuitry, the second decision circuitry is controlled described rechargeable battery and discharged to pacemaker electrode.
20. according to the method described in claim 18 or 19, it is characterized in that, the span of described setting limit value is the 50%-95% of described battery module Full Charge Capacity.
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