CN107970523A - A kind of implanted flexibility impulse generator - Google Patents
A kind of implanted flexibility impulse generator Download PDFInfo
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- CN107970523A CN107970523A CN201610961848.XA CN201610961848A CN107970523A CN 107970523 A CN107970523 A CN 107970523A CN 201610961848 A CN201610961848 A CN 201610961848A CN 107970523 A CN107970523 A CN 107970523A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36125—Details of circuitry or electric components
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/378—Electrical supply
- A61N1/3785—Electrical supply generated by biological activity or substance, e.g. body movement
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- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Electrotherapy Devices (AREA)
Abstract
The invention discloses a kind of implanted flexibility impulse generator, including the flexible energy conversion unit by flexible package, with the Power Management Unit being stacked, energy-storage units and the integrated circuit unit encapsulated by the second encapsulated layer, energy conversion unit is connected by conducting wire with Power Management Unit, each unit is flexible structure, wherein, Power Management Unit, the electric energy for energy conversion unit to be produced are converted into suitable for being stored in the regulated power of energy-storage units；Receive and handle the feedback signal from integrated circuit unit and monitor the charge condition of energy-storage units, and according to the discharge and recharge of monitoring situation control energy-storage units；Integrated circuit unit is connected with power supply energy administrative unit, for the generation and amplification of boost pulse, and collection, analysis and feedback from itself with human body coherent signal.Implantable Pulse Generator provided by the invention, disclosure satisfy that long term device power demand.
Description
Technical field
The present invention relates to built-in type device field, and in particular, to a kind of implanted flexibility impulse generator.
Background technology
In recent years, Implantable Pulse Generator (such as pacemaker, brain pacemaker etc.) is widely used in medical diagnosis
And therapy field, Implantable Pulse Generator (such as pacemaker, brain pacemaker etc.) are widely used in medical diagnosis and control
Treatment field, volume, quality and the battery durable of Implantable Pulse Generator etc. still suffers from huge challenge.
Flexible electronic technology is the electronic technology revolution started in recent years, causes global extensive concern and obtains
Develop rapidly.Its unique flexibility/ductility and efficiently, inexpensive manufacturing process can greatly reduce device into
Originally, size and weight, there is huge application prospect in implantable medical field.But in order to ensure certain service life, at present
The huge lithium battery that implantable medical device has to use hard to encapsulate is as power supply, therefore most of volume of whole device
Occupied with weight by battery, existing battery technology is difficult to take into account capacity and volume to reduce device size using flexible electronic technique
Space is very limited.
Friction nanometer power generator is using the position difference in friction potential sequence (Triboelectricity series)
Material there is a phenomenon where electronics transfer generates electricity when contacting with each other and/or rubbing.Nano generator has flexible, small, matter
The features such as light is measured, the energy that the biomechanical motion of in vivo produces can be converted into electric energy by it, be very suitable for driving
Dynamic implanted, portable and small-sized self-driving type electronic equipment.
Therefore flexible nano generator is combined with flexible electronic technology, may realizes built-in type device from power supply to function
Partly comprehensive flexibility, significantly reduces cost, size and the weight of device, so as to mitigate the body burden and economy of patient significantly
Burden.
The content of the invention
The object of the present invention is to provide a kind of implanted flexibility impulse generator, by flexible nano generator and flexible electrical
Sub- device combines, and obtains the implantable collection of energy of flexibility, solves asking for existing built-in type device size, weight and continuation of the journey
Topic.
To achieve these goals, the present invention provides a kind of implanted flexibility impulse generator, including：
Energy conversion unit, is packaged by the first flexible package layer；For the biomechanical energy of implant site to be converted
For electric energy；Power Management Unit, energy-storage units and integrated circuit unit, are packaged by the second encapsulated layer；The energy conversion
Unit is connected by conducting wire with the Power Management Unit；
Each unit is flexible structure, wherein, the Power Management Unit, for produce the energy conversion unit
Electric energy is converted into suitable for being stored in the regulated power of the energy-storage units；Receive and handle from the anti-of the integrated circuit unit
The charge condition of feedback signal and the monitoring energy-storage units, and according to the discharge and recharge of the monitoring situation control energy-storage units；
The integrated circuit unit, for the generation and amplification of boost pulse, and the collection from implant coherent signal, analysis and
Feedback.
Preferably, the Power Management Unit respectively with the energy conversion unit, energy-storage units and integrated circuit unit
Connection, the energy-storage units are connected by power supply energy administrative unit with the energy conversion unit and integrated circuit unit.
Preferably, the Power Management Unit, energy-storage units and integrated circuit unit for layer structure and are stacked.
Preferably, the energy conversion unit is using piezoelectric nano generator or the electric nano generator of friction.
Preferably, the structure of the friction nanometer power generator includes：
The first electrode layer fitted closely and the first frictional layer；
The second electrode lay and the second frictional layer fitted closely, second frictional layer separate face-to-face with the first frictional layer
Certain space is set；
Two frictional layers are contacted with each other separation by the effect of implant site organ biological energy source, in the first electrode layer and
Electric charge flowing is formed between two electrode layers.
Preferably, first frictional layer is different from the surface receiving and losing electrons ability of the second friction layer material.
Preferably, first frictional layer and the second friction layer material are conductor, semiconductor or insulator.
Preferably, the first friction layer material is semiconductor or insulator；
The second friction layer material is conductor, omits the second electrode lay.
Preferably, the Power Management Unit includes rectification circuit, potential device, stable-pressure device and controlling switch.
Preferably, the energy-storage units use flexible thin-film battery.
Preferably, the integrated circuit unit includes signal processing, perceives amplification, logic control function.
Preferably, the Power Management Unit, energy-storage units and integrated circuit unit carry out flexible package respectively.
Preferably, second encapsulated layer is flexible or rigid encapsulated layer.
Preferably, second encapsulated layer is Metal Packaging layer.
Preferably, the multilayer encapsulation knot that the first flexible package layer is organic material, inorganic material alternating encapsulation is formed
Structure；
And/or the flexible package layer forms single encapsulating structure for organic and inorganic mixing material.
Through the above technical solutions, the beneficial effects of the invention are as follows：
Implanted flexibility impulse generator provided by the invention, including the flexible energy conversion unit by flexible package,
With the Power Management Unit being stacked, energy-storage units and the integrated circuit unit encapsulated by the second encapsulated layer, using internal
The electric energy that biomechanical energy is transformed meets long term device power demand, solves the continuous of current Implantable Pulse Generator part
Boat problem.
The nano generator of impulse generator funtion part integrated circuit unit and energy conversion unit is individually sealed
Dress, allows energy conversion unit to be implanted near the organ of biomechanical energy, and the Power Management Unit of funtion part, storage
Energy unit and integrated circuit unit can be implanted in other positions, mitigate the burden for the organ for having biomechanical energy.
In addition, the present invention realizes the liter of other functional areas of device using flexible battery technology and flexible electronic technique
Level, so as to reduce the overall dimensions and weight and cost of device.Impulse generator has longer service life, the ruler of smaller
Very little, lighter weight and lower cost, it will greatly improve the use situation of current implantable medical device, promoting should
Field develops rapidly.
Brief description of the drawings
Attached drawing is for providing a further understanding of the present invention, and a part for constitution instruction, with following tool
Body embodiment is used to explain the present invention together, but is not construed as limiting the invention.In the accompanying drawings：
Fig. 1 is the structure diagram of the implanted flexibility impulse generator of the present invention；
Fig. 2 is the connection diagram of each unit in implanted flexibility impulse generator of the invention；
Fig. 3 is typical structure schematic diagram of the friction nanometer power generator as energy conversion unit.
Embodiment
The embodiment of the present invention is described in detail below in conjunction with attached drawing.It should be appreciated that this place is retouched
The embodiment stated is merely to illustrate and explain the present invention, and is not intended to limit the invention.
In the present invention, in the case where not making conversely explanation, the noun of locality such as " upper and lower " used refers to the side in diagram
To；" interior " refers to towards inside corresponding construction, and " outer " refers to towards outside corresponding construction.
At present Implantable Pulse Generator using the huge lithium battery of hard encapsulation as power supply, the size of lithium battery, again
Amount and continuation of the journey are that current Implantable Pulse Generator part develops faced main problem.The application is light-weight using small
Flexible nano generator, internal mechanical energy be converted into electric energy supplement device energy consumption by lasting, so that prominent
Broken limitation of the battery capacity to volume.Under the continued support of nano generator, it can be expired using the less flexible battery of capacity
The demand of sufficient device continuation of the journey for a long time.On this basis, the circuit of device and funtion part are prepared using flexible electronic technique,
Further optimised devices overall dimensions and weight.By flexible nano generator, flexible battery and flexible electronic technique processing
Power management, circuit and funtion part stack up, and the type implanting pulse for obtaining size, weight and cruising ability optimization occurs
Device.
Implanted flexibility impulse generator provided by the invention, the typical structure of device is referring to Fig. 1, including individually encapsulates
Two parts：Energy conversion unit 1, is packaged by the first flexible package layer 5；Power Management Unit 2, energy-storage units 3 and integrated
Circuit unit 4, is packaged by the second encapsulated layer 6；Wherein, energy part of the energy conversion unit 1 as the device, for inciting somebody to action
The biomechanical energy of implant site is converted into electric energy, is connected by conducting wire with Power Management Unit 2；Power Management Unit 2, energy storage
Unit 3 and integrated circuit unit 4 form the funtion part of impulse generator, and Power Management Unit 2 is used for energy conversion unit 1
The electric energy of generation is converted into suitable for being stored in the regulated power of energy-storage units 3, is received and is handled from the anti-of integrated circuit unit 4
Feedback signal and the charge condition for monitoring energy-storage units 3, and according to the discharge and recharge of monitoring situation control energy-storage units 3；Integrated electricity
Road unit 4 has the function of device signal collection, data processing and produces electric pulse etc..
In order to reduce energy consumption, energy conversion unit 1 and the distance between Power Management Unit 2 are as small as possible, to save
Connecting wire.
Compacter for the structure of impulse generator, Power Management Unit 2, energy-storage units 3 and integrated circuit unit 4 can
To use layer structure, it is stacked mutually.The manufacture of flexible electronic technique can be used to make Power Management Unit 2, energy storage list
Member 3 and integrated circuit unit 4 are flexible structure, to adapt to et al. Ke environment.
Different funtion parts is individually packaged by the impulse generator of the present invention, and the connection between each unit is referring to figure
2.Energy conversion unit 1, energy-storage units 3 and integrated circuit unit 4 are respectively connected to Power Management Unit 2.Energy conversion unit 1
It is sustainable that internal biomechanical energy (such as heartbeat, breathing, body movement) is converted into electric energy (alternating current), this part electricity
The stable DC electricity to be adapted to charging to use can be handled by Power Management Unit 2, and it is (such as soft to be temporarily stored in energy-storage units 3
Property battery) among.Energy-storage units 3 (flexible battery) carry out relevant processing with stable energy resource supply integrated circuit unit 4, and
Electric pulse is discharged for stimulating electrode by Pacing lead 8, stimulation therapy is carried out to privileged site.
In the present embodiment, flexible energy conversion unit 1 can use nano generator, flexible nano generator 1
Structure can be the nano generator of existing any structure, include the friction of the nano generator and friction structure of piezoelectric structure
Nano generator.
The typical structure of friction nanometer power generator is shown in Fig. 3, and separated two power generation parts can be contacted with each other by having, mutual
It is in contact in separation process since triboelectrification and electrostatic induction act on and to form electricity output.Friction nanometer power generator 1 includes close
11 and first frictional layer 12 of first electrode layer of fitting, forms the first power generation part；The second electrode lay 14 fitted closely and
Two frictional layers 13, form the second power generation part, and the second frictional layer 13 and the first frictional layer 12 separate certain space setting face-to-face；
The modes such as isolated part or domes can be set between the first frictional layer 12 and the second frictional layer 13 in two frictional layers
Between form gap.Two frictional layers of friction nanometer power generator 1 are contacted with each other point by the effect of implant site organ biological energy source
From since the surface receiving and losing electrons ability of two friction layer materials is different, under triboelectrification and electrostatic induction effect, in the first electricity
Electric charge flowing is formed between pole layer 11 and the second electrode lay 14, realizes and the mechanical energy of organ movement is changed into electric energy.
In friction nanometer power generator 1, the material selection range of the first frictional layer 12 and the second frictional layer 13 is very wide, herein
It is not particularly limited, can is conductor, semiconductor or insulating material, as long as the material of two kinds of frictional layers has to obtain dead electricity
Sub- capacity variance.If the material selection conductor of the second frictional layer 13, the second electrode lay 14, the second friction may be omitted with
Layer 13 functions simultaneously as frictional layer and electrode layer.In the present invention, each part of friction nanometer power generator uses flexible material, with
The motion mode of its implant site is adapted to, and maximum possible absorbs internal biomechanical energy..Such as:First friction
Material selection PET, PI, PTFE, PDMS of 12 and second frictional layer 13 of layer etc. possess flexible and biocompatibility macromolecule material
The nano level metal coating such as material, the material selection gold, silver of first electrode layer 11 and the second electrode lay 14, copper, aluminium, titanium, can also
Select other conductive materials such as carbon nanotubes, conducting polymer, ITO.
Certainly, the friction nanometer power generator of the present embodiment needs to carry out flexible package, the wire portion for electric signal output
Point, the electrode layer of friction nanometer power generator draws encapsulated layer by conducting wire in practical devices, is connected with Power Management Unit 2.
The effect of first flexible package layer 5 is insulation and protection built-in component, makes friction nanometer power generator from external complex physiologic ring
The influence in border.
In order to save space, make device architecture compacter, Power Management Unit 2, energy-storage units 3 in funtion part
With integrated circuit unit 4, layer structure can be used, and be stacked.The order of stacking is not specially limited, and sequentially may be used
To exchange.
Power Management Unit 2, based on existing flexible electronic technique, will have rectification, transformation, current stabilization and discharge and recharge intelligence
The funtion part that the circuit production of the power management functions such as control is formed in flexible macromolecule/metallic substrates.Power management list
Member 2 is energy bridge joint, the part of transfer in device, is connected respectively with energy conversion unit 1, energy-storage units 3, integrated circuit unit 4
Connect.
The major function of Power Management Unit 2 has two parts：1) by the friendship that such as nano generator produces of energy conversion unit 1
The unstable electric energy of impulse form is flowed, is converted into the regulated power for being suitable for such as battery charging of energy-storage units 3, and further pass through
Connection circuit is stored in energy-storage units 3；2) receive and handle feedback signal and monitoring battery from integrated circuit unit 4
Charge condition；The charging/discharging function of energy-storage units 3 is controlled according to these signals, realizes the intermittent phase (people in pulse generation function
When electro photoluminescence is not required in body) electric discharge is terminated in due course；And stop charging in due course in 3 electricity saturation of energy-storage units.Power management
2 layers of unit can carry out independent flexible package, to protect internal component.
The specific device of Power Management Unit 2 can include rectification circuit, potential device, stable-pressure device and controlling switch etc.
Device.
Energy-storage units 3 can use flexible thin-film battery (such as battery capacity is more than 100mAh), for storing
The electric energy that vivo biodistribution mechanical movement is transformed by energy conversion unit 1, and integrated circuit unit 4 is supplied to when needed
Carry out signal acquisition, processing and the functional activities such as electric pulse occur.Energy-storage units 3 are connected with power supply energy administrative unit 2, and
Established and connected by power supply energy administrative unit 2 and energy conversion unit 1 and integrated circuit unit 4.3 layers of energy-storage units can be into
The independent flexible package of row, to protect internal component.
Integrated circuit unit 4 is based on existing flexible electronic technique, is IC functional circuits by existing pacemaker in addition to the battery
The functional layer formed in flexible macromolecule/metallic substrates is produced on, including signal processing, perception amplification, logic control etc. are mainly
Function.4 part of integrated circuit unit is mainly responsible for the generation and amplification of boost pulse, and from implant such as human body or animal
Collection, analysis and the feedback of body coherent signal.The part is mainly attached with power supply energy administrative unit 2, receives electric energy confession
Feedback signal should and be provided.4 layers of integrated circuit unit can carry out independent flexible package, to protect internal component.
The above-mentioned each section of impulse generator can be respectively provided with independent flexible package, play insulation and the internal member of protection
The effect of part, makes each unit from the influence of external complex physiological environment.In addition, the second encapsulated layer 6 can be flexible package,
Can be hardness encapsulation, be packaged for example with Metal Packaging layer or flexible organic material is packaged, using with
The encapsulated layer of biological safety, mainly for the protection of the electricity of internal power management unit 2, energy-storage units 3 and integrated circuit unit 4
Influence of the sub- component from external complex physiological environment and from implant site mechanical shock.
The Pacing lead 6 that connection integrated circuit unit 4 (IC circuit units) can be drawn from the second encapsulated layer 6 is used for for thorn
Swash electrode etc. and power supply is provided.
First flexible package layer 5 is using flexible organic (such as high molecular material) material and inorganic (such as metal and metal compound
Thing) material preparation.The usually organic and inorganic material multilayer encapsulation structure that alternately encapsulation is formed.Flexible multi-layered encapsulating structure, example
Such as PDMS and the alternate stepped construction of metal oxide.Metal oxide is generally aluminium oxide, zirconium oxide, silica etc..
The impulse action that Pacing lead 6 is used to produce device is in respective regions.According to the difference of device implant site, lead
Line length can be adapted to accordingly.
The preferred embodiment of the present invention is described in detail above in association with attached drawing, still, the present invention is not limited to above-mentioned reality
The detail in mode is applied, in the range of the technology design of the present invention, a variety of letters can be carried out to technical scheme
Monotropic type, these simple variants belong to protection scope of the present invention.For example, the change of the shape, material and size of each component.
It is further to note that each particular technique feature described in above-mentioned embodiment, in not lance
In the case of shield, it can be combined by any suitable means.In order to avoid unnecessary repetition, the present invention to it is various can
The combination of energy no longer separately illustrates.In addition, any group can also be carried out between a variety of embodiments of the present invention
Close, as long as it without prejudice to the thought of the present invention, it should equally be considered as content disclosed in this invention.
Claims (15)
- A kind of 1. implanted flexibility impulse generator, it is characterised in that including：Energy conversion unit, is packaged by the first flexible package layer；For the biomechanical energy of implant site to be converted into electricity Energy；Power Management Unit, energy-storage units and integrated circuit unit, are packaged by the second encapsulated layer；The energy conversion unit It is connected by conducting wire with the Power Management Unit；Each unit is flexible structure, wherein, the Power Management Unit, for the electric energy for producing the energy conversion unit It is converted into suitable for being stored in the regulated power of the energy-storage units；Receive and handle the feedback letter from the integrated circuit unit Number and the monitoring energy-storage units charge condition, and control according to monitoring situation the discharge and recharge of the energy-storage units；It is described Integrated circuit unit, for the generation and amplification of boost pulse, and the collection from implant coherent signal, analysis and anti- Feedback.
- 2. impulse generator according to claim 1, it is characterised in that the Power Management Unit respectively with the energy Conversion unit, energy-storage units are connected with integrated circuit unit, and the energy-storage units pass through power supply energy administrative unit and the energy Amount conversion unit is connected with integrated circuit unit.
- 3. impulse generator according to claim 1 or 2, it is characterised in that the Power Management Unit, energy-storage units and Integrated circuit unit is layer structure and is stacked.
- 4. according to the impulse generator described in claim any one of 1-3, it is characterised in that the energy conversion unit uses Piezoelectric nano generator or the electric nano generator of friction.
- 5. impulse generator according to claim 4, it is characterised in that the structure of the friction nanometer power generator includes：The first electrode layer fitted closely and the first frictional layer；The second electrode lay and the second frictional layer fitted closely, second frictional layer and the first frictional layer separate necessarily face-to-face Space is set；Two frictional layers are contacted with each other separation by the effect of implant site organ biological energy source, in the first electrode layer and the second electricity Electric charge flowing is formed between the layer of pole.
- 6. impulse generator according to claim 7, it is characterised in that first frictional layer and the second friction layer material Surface receiving and losing electrons ability it is different.
- 7. the impulse generator according to claim 5 or 6, it is characterised in that first frictional layer and the second frictional layer Material is conductor, semiconductor or insulator.
- 8. the impulse generator according to claim 5 or 6, it is characterised in that the first friction layer material is semiconductor Or insulator；The second friction layer material is conductor, omits the second electrode lay.
- 9. according to claim 1-8 any one of them impulse generators, it is characterised in that the Power Management Unit includes whole Current circuit, potential device, stable-pressure device and controlling switch.
- 10. according to claim 1-9 any one of them impulse generators, it is characterised in that the energy-storage units are using flexible Hull cell.
- 11. according to claim 1-10 any one of them impulse generators, it is characterised in that the integrated circuit unit includes Signal processing, perceive amplification, logic control function.
- 12. according to claim 1-11 any one of them impulse generators, it is characterised in that the Power Management Unit, storage Energy unit and integrated circuit unit carry out flexible package respectively.
- 13. according to claim 1-12 any one of them impulse generators, it is characterised in that second encapsulated layer is flexibility Or rigid encapsulated layer.
- 14. according to claim 1-12 any one of them impulse generators, it is characterised in that second encapsulated layer is metal Encapsulated layer.
- 15. according to claim 1-14 any one of them impulse generators, it is characterised in that the first flexible package layer is Organic material, inorganic material the multilayer encapsulation structure that alternately encapsulation is formed；And/or the flexible package layer is organic material, inorganic material is mixed to form single encapsulating structure.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610961848.XA CN107970523A (en) | 2016-11-04 | 2016-11-04 | A kind of implanted flexibility impulse generator |
| CN202211364151.6A CN115800801A (en) | 2016-11-04 | 2016-11-04 | Implanted flexible pulse generator |
| PCT/CN2017/109042 WO2018082593A1 (en) | 2016-11-04 | 2017-11-02 | Implantable flexible pulse generator |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610961848.XA CN107970523A (en) | 2016-11-04 | 2016-11-04 | A kind of implanted flexibility impulse generator |
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| CN202211364151.6A Division CN115800801A (en) | 2016-11-04 | 2016-11-04 | Implanted flexible pulse generator |
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| CN202211364151.6A Pending CN115800801A (en) | 2016-11-04 | 2016-11-04 | Implanted flexible pulse generator |
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| CN111408046A (en) * | 2020-04-16 | 2020-07-14 | 北京纳米能源与系统研究所 | Electrical stimulation system for promoting nerve repair in vivo |
| CN111631813A (en) * | 2020-05-27 | 2020-09-08 | 武汉联影智融医疗科技有限公司 | Automatic sequencing method, sequencing system, equipment and computer-readable storage medium for implantable electrodes |
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| CN115800801A (en) | 2023-03-14 |
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