CN103550762B - Novel vaccine distributing equipment and distributed-vaccine production method - Google Patents
Novel vaccine distributing equipment and distributed-vaccine production method Download PDFInfo
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- CN103550762B CN103550762B CN201310525337.XA CN201310525337A CN103550762B CN 103550762 B CN103550762 B CN 103550762B CN 201310525337 A CN201310525337 A CN 201310525337A CN 103550762 B CN103550762 B CN 103550762B
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Abstract
The invention relates to novel vaccine distributing equipment and a distributed-vaccine production method. The novel vaccine distributing equipment comprises a filtering device, a vaccine distributing barrel and a weighing magnetic agitator which are arranged from top to bottom in sequence. The distributed-vaccine production method comprises the steps of distributing vaccine, charging inert gas, agitating, and storing at low temperature. According to the novel vaccine distributing equipment, an agitating brush matched with a funnel is arranged at the upper end of a fixing frame and used for agitating a solution in the funnel and brushing the residual filtered tissue to the side edge of the funnel, so that a filter screen can be prevented from being blocked by the residual filtered tissue; an air ventilating port, an air inlet and a subpackaging and discharging port are formed in the neck part of a vaccine distributing barrel; more than one baffle plate is arranged on the inner wall of a batching barrel body, by which the vaccine liquid can be stopped and change the rotating direction during being agitated in the batching barrel by the magnetic agitator, thus large vortex cannot be produced, and as a result, the vaccine liquid can be highly uniformly mixed.
Description
Technical field
The present invention relates to vaccine and join Seedling field, particularly relate to a kind of new generation vaccine and join Seedling equipment and join Seedling production method.
Background technology
Along with the continuous maturation of biotechnology, vaccines arts have also been obtained good development, and current vaccination is considered to the most effective measure of prevention to infectious disease.Seedling joined by vaccine is very important operation in live vaccine production process, and direct relation the quality of vaccine finished product quality.
The Seedling technological process of production joined by vaccine general at present: be filled in vial with a scale by one with the funnel that funnel fixing bracket is fixed after vaccine antigen thaws, funnel has a manual frotton, in order to accelerate the speed of filtering in the process of filtering, frotton constantly grinds the vaccine antigen in funnel by hand, being poured into by the vaccine antigen after vial with a scale measures appropriate filtration joins in Seedling bucket, join Seedling bucket without scale, and charging aperture is wide-mouth, join in Seedling bucket and a hand whisk is installed, after whole vaccine antigen joins and joins Seedling bucket, the protective agent of requirement joined join in Seedling bucket with being equipped with protectant vial (having scale), and constantly Seedling bucket is joined in stirring, the vaccine liquid prepared is stirred, finally preserve joining Seedling bucket and being put in the freezer of 2-8 DEG C, use to be packed.
This vaccine is joined the Seedling technological process of production and be there is following defect:
1) manual constantly grinding is needed when the funnel filtered filters, effort, efficiency is low, vaccine antigen after filtration needs to join after graduated vial measures joins in Seedling bucket, effort, exist and break because of carelessness due to vial, exist and vaccine caused damage and the risk of injury to personnel, measure antigen amount with vial not accurate enough simultaneously.
2), after whole vaccine antigen and protective agent join and join Seedling bucket, agitator mixes vaccine liquid by hand, and labor intensity is large.
3) charging aperture of joining Seedling bucket designs for wide-mouth, the diameter of charging aperture is identical with the diameter of joining Seedling bucket body, join Seedling bucket and there is no cervical region, if when loading amount is more, when being pulled to other positions with car, more easily rock vaccine liquid to be spilt and join outside Seedling bucket, exist and vaccine caused damage and the risk of injury to personnel.
4) vaccine antigen and protective agent vial measure, and measure not accurate enough, there is larger error.
5) join Seedling bucket non-fully Seal Design, can contact with air after vaccine liquid prepares, cause the physicochemical character of vaccine liquid by the gases affect such as oxygen, carbon dioxide in air.
Summary of the invention
Technical problem to be solved by this invention is: improve the degree of accuracy that vaccine joins vaccine antigen in Seedling process and protective agent dosage and vaccine liquid total amount; the labor intensity in Seedling joined by reduction vaccine; improve and join Seedling efficiency; reduce vaccine and join the breakage of waste and container used in Seedling process, the risk of injury to personnel, improve safety.
To achieve these goals, the present invention adopts following technical scheme:
A kind of new generation vaccine joins Seedling equipment, and it comprises the defecator sequentially arranged from top to bottom, joins Seedling bucket and magnetic stirring apparatus of weighing;
Be provided with the funnel of filter screen and the fixed mount of fixed funnel in described defecator comprises, described fixed mount upper end is provided with the Mixing Brush coordinated with funnel, and described Mixing Brush is connected with motor; Described funnel lower end with join Seedling bucket and coordinate;
Mixing Brush can play the effect to the solution stirring in funnel, the tissue that filtration is remaining can be brushed again the edge of funnel, make it not block filter screen.Mixing Brush is connected with motor, makes Mixing Brush realize automatization.
Described Seedling bucket of joining comprises and joins Seedling bucket body, described Seedling bucket body cervical region upper end of joining is provided with charging aperture, described charging aperture increases gradually to the cross section of joining Seedling bucket body cervical region lower end, the diameter that diameter due to charging aperture matches well Seedling bucket body is little, therefore be not easy vaccine liquid is spilt during running, Loss reducing; Join Seedling bucket body cervical region and be provided with blow vent, air inlet and subpackage discharging opening, mixer inner body wall is provided with more than one baffle plate, when unlatching magnetic stirring apparatus is stirred the vaccine liquid in mixer, the vaccine liquid be stirred is subject to the stop of baffle plate, the direction of rotation can be changed, large vortex can not be formed, therefore make that vaccine liquid mixes evenly; Described mixer is placed in weighs on magnetic stirring apparatus;
Described magnetic stirring apparatus of weighing comprises magnetic stirring apparatus and weighing device; described weighing device is located at and is weighed in magnetic stirring apparatus; described magnetic stirring apparatus one end of weighing is provided with the weight display be connected with weighing device; weighing device joins vaccine antigen in Seedling bucket and protective agent weighs to joining; magnetic stirring apparatus can stir the vaccine liquid of joining in Seedling bucket, saves manpower.
Universal wheel is provided with bottom the fixed mount of described defecator.Can move defecator as required.
It is described that to join Seedling bucket body diameter be 50-70cm, height is 70-90cm, can regulate the size of joining Seedling bucket as required, the capacity of joining Seedling bucket is 120-180L, intake port is 15-25cm, the diameter that the diameter of charging aperture matches well Seedling bucket body is little, ensures to be not easy vaccine liquid is spilt when joining the running of Seedling bucket.
Described Seedling bucket of joining also comprises upper cover, and described upper cover is fastened on the edge of opening of charging aperture, joins after Seedling terminates, is fastened by upper cover, reduces the pollution of joining dust etc. that the vaccine liquid in Seedling bucket touches air or air and causing it.
Described Seedling bucket body outer wall of joining is provided with handle, conveniently moves or moves and join Seedling bucket.
Be respectively equipped with valve in described blow vent, air inlet and subpackage discharging opening, conveniently control the folding of blow vent, air inlet and subpackage discharging opening.
Described plate washer is four, and effect is best, and baffle plate is wide is 4-6cm, its lower end is 5-15cm apart from joining Seedling bucket body bottom portion, do not disturb the running of magnetic stir bar, upper end extends to joins Seedling bucket body cervical region lower end, ensures that most of vaccine liquid of joining in Seedling bucket can both touch.
Weight display one end of described magnetic stirring apparatus of weighing is also provided with pushing hands, the movement of magnetic stirring apparatus of conveniently weighing.
Universal wheel is provided with, the movement of magnetic stirring apparatus of conveniently weighing bottom described magnetic stirring apparatus of weighing.
Adopt above-mentioned new generation vaccine to join the production method of Seedling equipment, it comprises the following steps:
1) Seedling is joined: magnetic stir bar put into and join Seedling bucket, vaccine antigen after thawing is added in funnel, open the motor of defecator, drive Mixing Brush, vaccine antigen is filled into and joins in Seedling bucket, weigh the weight of vaccine antigen, after calculating need join the vaccine liquid total amount of Seedling according to the weight of vaccine antigen and proportioning thereof, protective agent is added in funnel to be filled into and join in Seedling bucket, stop until reaching the vaccine liquid total amount need joining Seedling;
2) filling with inert gas: cover the upper cover of joining Seedling bucket, closes the valve of blow vent, blow vent is connected vacuum pump, extract the air of joining in Seedling bucket out, air inlet passes into the noble gas after aseptic filtration, will join air in Seedling bucket and be replaced by noble gas, the impact of isolated outer bound pair vaccine liquid;
3) to stir and low temperature: open magnetic stirring apparatus, after being stirred by the vaccine liquid of joining in Seedling bucket, the magnetic stirring apparatus and join Seedling bucket and move to the preservation of 2-8 DEG C of freezer together of will weighing, waits to be packed.
New generation vaccine of the present invention is adopted to join Seedling equipment and join Seedling production method, by the defecator from top to bottom sequentially arranged, join Seedling bucket and magnetic stirring apparatus of weighing realizes vaccine and joins Automated condtrol in Seedling process, reduce vaccine and join labor intensity in Seedling, improve and join Seedling efficiency; Be provided with the funnel of filter screen and the fixed mount of fixed funnel in described defecator comprises, described fixed mount upper end is provided with the Mixing Brush coordinated with funnel, and described Mixing Brush is connected with motor; Described funnel lower end with join Seedling bucket and coordinate; Mixing Brush can play the effect to the solution stirring in funnel, the tissue that filtration is remaining can be brushed again the edge of funnel, make it not block filter screen.Mixing Brush is connected with motor, makes Mixing Brush realize automatization.Described Seedling bucket of joining comprises and joins Seedling bucket body, described Seedling bucket body cervical region upper end of joining is provided with charging aperture, described charging aperture increases gradually to the cross section of joining Seedling bucket body cervical region lower end, the diameter that diameter due to charging aperture matches well Seedling bucket body is little, therefore be not easy vaccine liquid is spilt during running, Loss reducing; Join Seedling bucket body cervical region and be provided with blow vent, air inlet and subpackage discharging opening, mixer inner body wall is provided with more than one baffle plate, when unlatching magnetic stirring apparatus is stirred the vaccine liquid in mixer, the vaccine liquid be stirred is subject to the stop of baffle plate, the direction of rotation can be changed, large vortex can not be formed, therefore make that vaccine liquid mixes evenly; Described magnetic stirring apparatus of weighing comprises magnetic stirring apparatus and weighing device; described weighing device is located at and is weighed in magnetic stirring apparatus; described magnetic stirring apparatus one end of weighing is provided with the weight display be connected with weighing device; weighing device joins vaccine antigen in Seedling bucket and protective agent weighs to joining; improve the degree of accuracy that vaccine joins vaccine antigen in Seedling process and protective agent dosage and vaccine liquid total amount; magnetic stirring apparatus can stir the vaccine liquid of joining in Seedling bucket, saves manpower.Decrease the use of glass drying oven in the present invention, reduce vaccine and join the breakage of waste and container used in Seedling process, the risk of injury to personnel, improve safety.
Accompanying drawing explanation
Illustrate that the present invention is further detailed explanation with detailed description of the invention below in conjunction with accompanying drawing:
Fig. 1 is the structural representation that a kind of new generation vaccine of the present invention joins Seedling equipment;
Fig. 2 is the structural representation that a kind of new generation vaccine of the present invention joins Mixing Brush in Seedling equipment.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is further detailed explanation:
As shown in Figure 1-2, a kind of new generation vaccine of the present invention joins Seedling equipment, and it comprises the defecator 1 sequentially arranged from top to bottom, joins Seedling bucket 2 and magnetic stirring apparatus 3 of weighing;
Be provided with the funnel 11 of filter screen 111 and the fixed mount 12 of fixed funnel 11 in described defecator 1 comprises, described fixed mount 12 upper end is provided with the Mixing Brush 13 coordinated with funnel 11, and described Mixing Brush 13 is connected with motor; Described funnel 11 lower end with join Seedling bucket 2 and coordinate; Mixing Brush 13 can play the effect to the solution stirring in funnel 11, the tissue that filtration is remaining can be brushed again the edge of funnel 11, make it can not block filter screen 111.Mixing Brush 13 is connected with motor, makes Mixing Brush realize automatization.
Described Seedling bucket 2 of joining comprises and joins Seedling bucket body 21, described Seedling bucket body 21 cervical region upper end of joining is provided with charging aperture 22, described charging aperture 22 increases gradually to the cross section of joining Seedling bucket body 21 cervical region lower end, the diameter that diameter due to charging aperture 22 matches well Seedling bucket body 21 is little, therefore be not easy vaccine liquid is spilt during running, Loss reducing; Join Seedling bucket body 21 cervical region and be provided with blow vent 23, air inlet 24 and subpackage discharging opening 25, mixer body 21 inwall is provided with more than one baffle plate 26, when vaccine liquid in unlatching magnetic stirring apparatus 31 pairs of mixers 2 is stirred, the vaccine liquid be stirred is subject to the stop of baffle plate 26, the direction of rotation can be changed, large vortex can not be formed, therefore make that vaccine liquid mixes evenly; Described mixer 2 is placed in weighs on magnetic stirring apparatus 3;
Described magnetic stirring apparatus 3 of weighing comprises magnetic stirring apparatus 31 and weighing device (not marking in figure); described weighing device is located at and is weighed in magnetic stirring apparatus 3; described magnetic stirring apparatus 3 one end of weighing is provided with the weight display 32 be connected with weighing device; weighing device joins vaccine antigen in Seedling bucket 2 and protective agent weighs to joining; magnetic stirring apparatus 31 can stir the vaccine liquid of joining in Seedling bucket 2, saves manpower.
Universal wheel 14 is provided with bottom the fixed mount 12 of described defecator 1.Can move defecator 1 as required.
It is described that to join Seedling bucket body 21 diameter be 50-70cm, height is 70-90cm, can regulate the size of joining Seedling bucket 2 as required, the capacity of joining Seedling bucket 2 is 120-180L, charging aperture 22 diameter is 15-25cm, the diameter that the diameter of charging aperture 22 matches well Seedling bucket body 21 is little, ensures to join when Seedling bucket 2 operates to be not easy vaccine liquid is spilt.
Described Seedling bucket 2 of joining also comprises upper cover (not marking in figure), and described upper cover is fastened on the edge of opening of charging aperture 22, joins after Seedling terminates, is fastened by upper cover, reduces the pollution of joining dust etc. that the vaccine liquid in Seedling bucket 2 touches air or air and causing it.
Described Seedling bucket body 21 outer wall of joining is provided with handle 27, conveniently moves or moves and join Seedling bucket 2.
Valve 28 is respectively equipped with, the convenient folding controlling blow vent 23, air inlet 24 and subpackage discharging opening 25 in described blow vent 23, air inlet 24 and subpackage discharging opening 25.
Described plate washer 26 is four, and effect is best, and baffle plate 26 is wide is 4-6cm, its lower end is 5-15cm apart from joining bottom Seedling bucket body 21, do not disturb the running of magnetic stir bar, upper end extends to joins Seedling bucket body 21 cervical region lower end, ensures that most of vaccine liquid of joining in Seedling bucket 2 can both touch.
Weight display 32 one end of described magnetic stirring apparatus 3 of weighing is also provided with pushing hands 33, the movement of magnetic stirring apparatus 3 of conveniently weighing.
Universal wheel 34 is provided with, the movement of magnetic stirring apparatus 3 of conveniently weighing bottom described magnetic stirring apparatus 3 of weighing.
Adopt above-mentioned new generation vaccine to join the production method of Seedling equipment, it comprises the following steps:
1) Seedling is joined: magnetic stir bar put into and join Seedling bucket 1, vaccine antigen after thawing is added in funnel 11, open the motor of defecator 1, drive Mixing Brush 13, vaccine antigen is filled into and joins in Seedling bucket 1, weigh the weight of vaccine antigen, after calculating need join the vaccine liquid total amount of Seedling according to the weight of vaccine antigen and proportioning thereof, protective agent is added in funnel 11 to be filled into and join in Seedling bucket 1, stop until reaching the vaccine liquid total amount need joining Seedling;
2) filling with inert gas: the stirrer adding magnetic stirring apparatus 31, cover the upper cover 27 of joining Seedling bucket 1, close the valve 29 of blow vent 23, blow vent 23 is connected vacuum pump, extract the air of joining in Seedling bucket 1 out, air inlet 24 passes into the noble gas after aseptic filtration, will join 1 air in Seedling bucket and be replaced by noble gas, the impact of isolated outer bound pair vaccine liquid;
3) to stir and low temperature: open magnetic stirring apparatus 31, after being stirred by the vaccine liquid of joining in Seedling bucket 2, the magnetic stirring apparatus 3 and join Seedling bucket 2 and move to the preservation of 2-8 DEG C of freezer together of will weighing, waits to be packed.
Claims (8)
1. new generation vaccine joins a Seedling equipment, it is characterized in that: it comprises the defecator sequentially arranged from top to bottom, joins Seedling bucket and magnetic stirring apparatus of weighing;
Be provided with the funnel of filter screen and the fixed mount of fixed funnel in described defecator comprises, described fixed mount upper end is provided with the Mixing Brush coordinated with funnel, and described Mixing Brush is connected with motor; Described funnel lower end with join Seedling bucket and coordinate;
Described Seedling bucket of joining comprises and joins Seedling bucket body, described Seedling bucket body cervical region upper end of joining is provided with charging aperture, described charging aperture increases gradually to the cross section of joining Seedling bucket body cervical region lower end, described Seedling bucket of joining also comprises upper cover, described upper cover is fastened on the edge of opening of charging aperture, described Seedling bucket body cervical region of joining is provided with blow vent, air inlet and subpackage discharging opening, and be respectively equipped with valve in described blow vent, air inlet and subpackage discharging opening, mixer inner body wall is provided with more than one baffle plate; Described mixer is placed in weighs on magnetic stirring apparatus;
Described magnetic stirring apparatus of weighing comprises magnetic stirring apparatus and weighing device, and described weighing device is located at and is weighed in magnetic stirring apparatus, described in magnetic stirring apparatus one end of weighing be provided with the weight display be connected with weighing device.
2. a kind of new generation vaccine according to claim 1 joins Seedling equipment, it is characterized in that: be provided with universal wheel bottom the fixed mount of described defecator.
3. a kind of new generation vaccine according to claim 1 joins Seedling equipment, it is characterized in that: described in join Seedling bucket body diameter be 50-70cm, height is 70-90cm, and intake port is 15-25cm.
4. a kind of new generation vaccine according to claim 1 joins Seedling equipment, it is characterized in that: described in join Seedling bucket body outer wall and be provided with handle.
5. a kind of new generation vaccine according to claim 1 joins Seedling equipment, it is characterized in that: described plate washer is four, and baffle plate is wide is 4-6cm, and its lower end is 5-15cm apart from joining Seedling bucket body bottom portion, and upper end extends to joins Seedling bucket body cervical region lower end.
6. a kind of new generation vaccine according to claim 1 joins Seedling equipment, it is characterized in that: described in weigh weight display one end of magnetic stirring apparatus be also provided with pushing hands.
7. a kind of new generation vaccine according to claim 1 joins Seedling equipment, it is characterized in that: described in weigh bottom magnetic stirring apparatus and be provided with universal wheel.
8. adopt one of claim 1-7 described new generation vaccine to join the production method of Seedling equipment, it is characterized in that: it comprises the following steps:
1) Seedling is joined: magnetic stir bar put into and join Seedling bucket, vaccine antigen after thawing is added in funnel, open the motor of defecator, drive Mixing Brush, vaccine antigen is filled into and joins in Seedling bucket, weigh the weight of vaccine antigen, after calculating need join the vaccine liquid total amount of Seedling according to the weight of vaccine antigen and proportioning thereof, protective agent is added in funnel to be filled into and join in Seedling bucket, stop until reaching the vaccine liquid total amount need joining Seedling;
2) filling with inert gas: cover the upper cover of joining Seedling bucket, closes the valve of blow vent, blow vent is connected vacuum pump, extract the air of joining in Seedling bucket out, air inlet passes into the noble gas after aseptic filtration, will join air in Seedling bucket and be replaced by noble gas, the impact of isolated outer bound pair vaccine liquid;
3) to stir and low temperature: open magnetic stirring apparatus, after being stirred by the vaccine liquid of joining in Seedling bucket, the magnetic stirring apparatus and join Seedling bucket and move to the preservation of 2-8 DEG C of freezer together of will weighing, waits to be packed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310525337.XA CN103550762B (en) | 2013-10-30 | 2013-10-30 | Novel vaccine distributing equipment and distributed-vaccine production method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310525337.XA CN103550762B (en) | 2013-10-30 | 2013-10-30 | Novel vaccine distributing equipment and distributed-vaccine production method |
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| CN103550762A CN103550762A (en) | 2014-02-05 |
| CN103550762B true CN103550762B (en) | 2015-07-22 |
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| CN201310525337.XA Active CN103550762B (en) | 2013-10-30 | 2013-10-30 | Novel vaccine distributing equipment and distributed-vaccine production method |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105413554B (en) * | 2015-12-25 | 2018-09-18 | 奥星制药设备（石家庄）有限公司 | Match liquid platform and its stirring preparation and conveyer method based on disposable sterilized bag |
| CN114797566B (en) * | 2022-04-24 | 2023-04-14 | 北京中科健兰集团有限公司 | Production equipment and method of influenza B vaccine |
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| CN102575913A (en) * | 2009-09-04 | 2012-07-11 | Abec公司 | Heat transfer baffle system and uses thereof |
| CN203075866U (en) * | 2012-11-12 | 2013-07-24 | 福州大北农生物技术有限公司 | Movable type vaccine allocation tank |
| CN203525015U (en) * | 2013-10-30 | 2014-04-09 | 福州大北农生物技术有限公司 | Novel vaccine preparing equipment |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRMU8601558U (en) * | 2006-04-17 | 2007-12-11 | David Fredrick Smith | constructive arrangement introduced in egg vaccinator |
| US20110234061A1 (en) * | 2010-03-25 | 2011-09-29 | Vaxcare Corporation | Vaccination cart for optimized distribution and administration of vaccinations |
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- 2013-10-30 CN CN201310525337.XA patent/CN103550762B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102575913A (en) * | 2009-09-04 | 2012-07-11 | Abec公司 | Heat transfer baffle system and uses thereof |
| CN203075866U (en) * | 2012-11-12 | 2013-07-24 | 福州大北农生物技术有限公司 | Movable type vaccine allocation tank |
| CN203525015U (en) * | 2013-10-30 | 2014-04-09 | 福州大北农生物技术有限公司 | Novel vaccine preparing equipment |
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| CN103550762A (en) | 2014-02-05 |
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Address after: Gushan Town Park in Jinan District of Fuzhou city in Fujian province village 110 350000 Patentee after: Zhaofenghua Biotechnology (Fuzhou) Co.,Ltd. Address before: Gushan Town Park in Jinan District of Fuzhou city in Fujian province village 110 350000 Patentee before: FUZHOU DA BEI NONG BIOTECH Co.,Ltd. |
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Effective date of registration: 20200618 Address after: 211102, 999 Ting Dong Road, Jiangning economic and Technological Development Zone, Nanjing, Jiangsu Co-patentee after: Zhaofenghua Biotechnology (Fuzhou) Co.,Ltd. Patentee after: Zhaofenghua Biotechnology (Nanjing) Co.,Ltd. Address before: Gushan Town Park in Jinan District of Fuzhou city in Fujian province village 110 350000 Patentee before: Zhaofenghua Biotechnology (Fuzhou) Co.,Ltd. |