CN103550649A - 一种治疗连续性肢端皮炎的中药 - Google Patents
一种治疗连续性肢端皮炎的中药 Download PDFInfo
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Abstract
本发明涉及一种治疗连续性肢端皮炎的中药，由以下重量配比的药材制备而成：蛤蒌8份、秃疮花12份、土良姜12份、川牛膝10份、红花岩松14份、白花龙胆12份、破牛膝12份、骑马参14份、葛花8份、破天菜10份、云南丹参12份、毛葡萄16份、毛叶轮环藤12份、广防风14份、慈菇10份、紫背菜12份、大独脚金12份、棉籽10份。临床实验证明，本发明能够安全有效治疗连续性肢端皮炎。
Description
技术领域
本发明涉及一种中药，具体涉及一种治疗连续性肢端皮炎的中药。
背景技术
连续性肢端皮炎又称肢端脓疱病、脓疱性肢端皮炎、Hallopeau顽固性皮炎，为一种罕见的慢性复发性无菌性脓疱病，好发于指(趾)部，常在外伤后发病。病因与发病机制尚不明确，有人认为与细菌感染有关，或与体内感染病灶有关，亦有认为属脓疱性银屑病的一型。好发于中年，两性发病率无差别。多从手指的甲周起病，偶尔先发于足趾，常先有外伤感染，似甲沟炎，以后出现多数小脓疱或水疱，破溃、糜烂、结痂。
对于连续性肢端皮炎目前尚缺少公认安全有效的治疗药物。
本发明中药所涉及药材的研究现状如下：
蛤蒌【来源】胡椒科胡椒属植物假蒌Piper sarmentosum Roxb.，以全株、根、叶或果实入药。全株、根随时可采；叶及果秋季采集，晒干。【功能主治】温中散寒，祛风利湿，消肿止痛。用于胃肠寒痛，风寒咳嗽，水肿，疟疾，牙痛，风湿骨痛，跌打损伤。
秃疮花【来源】罂粟科秃疮花属植物秃疮花Dicranostigma leptopodum(Maxim.)Fedde，以全草入药。春夏采集，晒干。【功能主治】清热解毒，消肿止痛，杀虫。用于扁桃体炎，牙痛，淋巴结结核；外用治头癣，体癣。
土良姜【来源】为姜科姜花属植物土良姜.的根状茎，果实也入药。秋季采挖根状茎，洗净，切片，晒干或鲜用；秋冬收果实、种子，晒干。【功能主治】温中散寒，理气止痛。用于胃寒痛，呕吐，消化不良，寒疝气痛；外用治膝关节痛。
川牛膝【来源】本品为苋科植物川牛膝的干燥根。秋、冬二季采挖，除去芦头、须根及泥沙，炕或晒至半干，堆放回润，再炕干或晒干。【功能主治】逐瘀通经，通利关节，利尿通淋。用于经闭癥瘕，胞衣不下，关节痹痛，足痿筋挛，尿血血淋，跌扑损伤。
红花岩松【来源】景天科华景天属植物石莲。【功能主治】清热解毒，止血止痢。用于咽喉肿痛，痢疾，崩漏，便血；外用治疮疡久不收口，烧烫伤。
白花龙胆【来源】龙胆科龙胆属植物高山龙胆，以全草入药。7～9月采挖带根全草，洗净晒干。【功能主治】清肝胆，除湿热，健胃。用于流行性脑脊髓膜炎，目赤，烟痛，肺热咳嗽，胃炎，尿痛，阴痒，阴囊湿疹。
破牛膝【来源】毛茛科银莲花属植物小花草玉梅，以根或全草入药。夏秋采收，洗净晒干。【功能主治】健胃消食，散瘀消结。用于肝炎，阴疽，痈肿作痛。
骑马参【来源】兰科舌唇兰属植物舌唇兰，以带根全草入药。夏季采挖，洗净，晒干。【功能主治】润肺，祛痰止咳。用于肺热咳嗽，喘咳。
葛花【来源】豆科植物野葛或甘葛藤的花。秋季采集，晒干，生用。【功能主治】解酒止渴。用于酒醉烦渴。
破天菜【来源】桔梗科山梗菜属植物破天菜，以根或全草入药。秋季采集，洗净，根切片，晒干或鲜用。【功能主治】消炎，止痛，解毒，杀虫。用于风湿性关节炎，跌打损伤，疮疡肿毒。
云南丹参【来源】唇形科鼠尾草属植物云南丹参以根入药。秋季采挖，洗净切片晒干。【功能主治】活血调经，行瘀止痛。用于月经不调，闭经，痛经，产后腹痛，跌打损伤，关节疼痛，疝痛，腰痛，痈疮肿毒。
毛葡萄【来源】葡萄科葡萄属植物毛葡萄。【功能主治】根皮：调经活血，舒筋活络。用于月经不调，白带；外用治跌打损伤，筋骨疼痛。叶：止血。用于外伤出血。
毛叶轮环藤【来源】为防己科轮环藤属植物毛叶轮环藤，以根入药。全年可采，去净泥土，切片晒干。【功能主治】散热解毒，散淤止痛。用于急性扁桃体炎，咽喉炎，牙痛，胃痛，腹痛，胃肠炎，疟疾，跌打损伤。
广防风【来源】唇形科防风草属植物广防风，以全草入药。夏秋采收，洗净，鲜用或晒干。【功能主治】祛风解表，理气止痛。用于感冒发热，风湿关节痛，胃痛，胃肠炎；外用治皮肤湿疹，神经性皮炎，虫蛇咬伤，痈疮肿毒。
慈菇【来源】泽泻科慈菇属植物慈，以球茎及全草入药。秋季采集，洗净晒干。【功能主治】清热止血，解毒消肿，散结。用于咯血，吐血，难产，产后胞衣不下，崩漏带下，尿路结石，小儿丹毒；外用治痈肿疮毒，毒蛇咬伤。
紫背菜【来源】菊科土三七属植物紫背菜.，以全草或茎、叶入药。全年可采。因茎、叶富含水汁，难以晒干，一般多鲜用。【功能主治】凉血止血，清热消肿。用于咳血，血崩，痛经，血气痛，支气管炎，盆腔炎，中暑，阿米巴痢疾；外用治创伤出血，溃疡久不收口，疔疮痈肿，甲沟炎。
大独脚金【来源】玄参科独脚金属植物大独脚金以全草入药。夏秋采集，切碎，晒干。【功能主治】健脾消食，清热利湿。用于小儿疳积，食欲不振，泌尿道感染，黄疸型肝炎。
棉籽【来源】锦葵科棉属植物草棉、树棉(中国棉)及陆地棉(高地棉)的种籽。夏秋采收，晒干。【功能主治】补肝肾，强腰膝，暖胃止痛，止血，催乳。用于月经过多，功能性子宫出血，乳汁缺乏，胃痛，腰膝无力。
发明内容
本发明旨在提供一种治疗连续性肢端皮炎的中药，通过选择合适的药材及其配比，达到安全有效治愈连续性肢端皮炎的目的。
为了达到上述目的，本发明采用以下技术方案：
一种治疗连续性肢端皮炎的中药，其特征在于，由以下重量配比的药材制备而成：蛤蒌8份、秃疮花12份、土良姜12份、川牛膝10份、红花岩松14份、白花龙胆12份、破牛膝12份、骑马参14份、葛花8份、破天菜10份、云南丹参12份、毛葡萄16份、毛叶轮环藤12份、广防风14份、慈菇10份、紫背菜12份、大独脚金12份、棉籽10份。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2008年4月-2011年8月间共收集100例连续性肢端皮炎的门诊患者，年龄25-58岁，病程1-7年。随机分为：治疗组70例，空白组30例。两组年龄、病情等资料无显著性差异，具有可比性。
2、试验方法
2.1治疗组口服本发明按照具体实施例1制得的胶囊，早晚各一次。疗程15天。
2.2空白组口服安慰剂胶囊，早晚各一次。疗程15天。
3、疗效标准与治疗结果
3.1疗效标准
痊愈：临床症状全部消失，试验室检查正常。好转：临床症状减轻，病情得到控制，实验室检查改善或正常。无效：临床症状无明显好转或加重。
3.2治疗统计结果见表1。
表1 两组疗效比较
| 组别 | n | 痊愈 | 好转 | 无效 | 不良反应例 | 总有效率(％) |
| 治疗组 | 70 | 13(18.6％) | 40(57.1％) | 17(24.2％) | 0 | 75.7％ |
| 空白组 | 30 | 0 | 6(20％) | 24(80％) | 0 | 20％ |
可见，本发明制得的药物能够安全有效治连续性肢端皮炎。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
具体实施例1
称取：蛤蒌8克、秃疮花12克、土良姜12克、川牛膝10克、红花岩松14克、白花龙胆12克、破牛膝12克、骑马参14克、葛花8克、破天菜10克、云南丹参12克、毛葡萄16克、毛叶轮环藤12克、广防风14克、慈菇10克、紫背菜12克、大独脚金12克、棉籽10克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，装入胶囊壳，即得符合正常成人1天用量的胶囊剂。
用于治疗连续性肢端皮炎。口服，每日分早晚两次服用。
具体实施例2
称取：蛤蒌8克、秃疮花12克、土良姜12克、川牛膝10克、红花岩松14克、白花龙胆12克、破牛膝12克、骑马参14克、葛花8克、破天菜10克、云南丹参12克、毛葡萄16克、毛叶轮环藤12克、广防风14克、慈菇10克、紫背菜12克、大独脚金12克、棉籽10克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，粉碎，即得符合正常成人1天用量的散剂。
用于治疗连续性肢端皮炎。口服，每日分早晚两次服用。
具体实施例3
称取：蛤蒌8克、秃疮花12克、土良姜12克、川牛膝10克、红花岩松14克、白花龙胆12克、破牛膝12克、骑马参14克、葛花8克、破天菜10克、云南丹参12克、毛葡萄16克、毛叶轮环藤12克、广防风14克、慈菇10克、紫背菜12克、大独脚金12克、棉籽10克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，再加入适量糊精和矫味剂，按照本领域常规工艺制粒，包装，即可制得符合正常成人1天用量的颗粒剂。
用于治疗连续性肢端皮炎。口服，每日分早晚两次服用。
Claims (1)
1.一种治疗连续性肢端皮炎的中药，其特征在于，由以下重量配比的药材制备而成：蛤蒌8份、秃疮花12份、土良姜12份、川牛膝10份、红花岩松14份、白花龙胆12份、破牛膝12份、骑马参14份、葛花8份、破天菜10份、云南丹参12份、毛葡萄16份、毛叶轮环藤12份、广防风14份、慈菇10份、紫背菜12份、大独脚金12份、棉籽10份。
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| CN101152409A (zh) * | 2007-09-18 | 2008-04-02 | 尹克山 | 治疗郁积性皮炎的中药 |
| CN101461890A (zh) * | 2007-12-17 | 2009-06-24 | 王清河 | 一种治疗皮炎的中药制剂及其制备方法 |
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| CN101152409A (zh) * | 2007-09-18 | 2008-04-02 | 尹克山 | 治疗郁积性皮炎的中药 |
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