CN103550615A - 一种治疗脾肾两虚证型泄泻病的中药 - Google Patents
一种治疗脾肾两虚证型泄泻病的中药 Download PDFInfo
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Abstract
本发明公开了一种治疗脾肾两虚证型泄泻病的中药，其特征是由下列重量配比的原料制成的：黄芪30份、当归15份、葛根24份、熟地黄30份、桃仁10份、红花20份、桂枝20份、土鳖虫10份、杜仲10份、牛膝15份、桑寄生15份、桔梗10份、甘草6份、炒白芍30份、牡蛎30份、蜈蚣1条、山茱萸15份、薏苡仁30份、伸筋草30份、鸡血藤30份。本发明的采用适宜的中药，各种药物之产是相互配合，协调作用，所制得的中药具有温肾健脾，温阳固涩止泻的功效，能有效治疗脾肾两虚证型泄泻病，五年来，通过对168名患者的使用表明，有效率达94%，治疗效果好，愈后不再复发。
Description
技术领域
本发明涉及一种中药，特别是一种用于治疗脾肾两虚证型泄泻病的中药。
背景技术
泄泻是指大便次数增多，粪便稀薄，甚至泻出如水样的病证。大便溏薄而势缓者为泄，大便清稀如水而直下者为泻。泄泻的证型有多种，如寒湿内证盛证型、湿热伤中证型、脾肾两虚证型等，脾肾两虚证型为常见的泄泻。目前治疗脾肾两虚证型泄泻病，西医一般只是单纯采用止泻类药，所以用药效果不好，而且只是治标不治本，即使有的患者当时被治好了，但过后很快就会复发，并且还有许多副作用，中医治疗泄泻病具有标本兼治的效果，而且副作用少，但目前还没有一种专用于治疗脾肾两虚证型泄泻病的中药。
发明内容
本发明旨在提供一种治疗脾肾两虚证型泄泻病的中药，通过选择合适的药材及其配比，达到安全有效治疗脾肾两虚证型泄泻病的目的。
为达到上述目的，本发明采用以下技术方案：一种治疗脾肾两虚证型泄泻病的中药，其特征是由下列重量配比的原料制成的：
黄芪30份、当归15份、葛根24份、熟地黄30份、桃仁10份、红花20份、桂枝20份、土鳖虫10份、杜仲10份、牛膝15份、桑寄生15份、桔梗10份、甘草6份、炒白芍30份、牡蛎30份、蜈蚣1条、山茱萸15份、薏苡仁30份、伸筋草30份、鸡血藤30份。
本发明配方中所述的各种药材的来源及功能主治如下：
黄芪【来源】 本品为豆科植物蒙古黄芪 Astragalus membranaceus （Fisch.） Bge. var. mongholicus （Bge.）Hsiao 或膜荚黄芪 Astragalus membranaceus （Fisch.） Bge.的干燥根。【性味】 甘，温。【归经】 归肺、脾经。【功能主治】 补气固表，利尿托毒，排脓，敛疮生肌。用于气虚乏力，食少便溏，中气下陷，久泻脱肛，便血崩漏，表虚自汗，气虚水肿，痈疽难溃，久溃不敛，血虚痿黄，内热消渴；慢性肾炎蛋白尿，糖尿病。
当归【来源】 本品为伞形科植物当归Angelica sinensis （Oliv.） Diels 的干燥根。【性味】 甘、辛，温。【归经】 归肝、心、脾经。
【功能主治】 补血活血，调经止痛，润肠通便。用于血虚萎黄，眩晕心悸，月经不调，经闭痛经，虚寒腹痛，肠燥便秘，风湿痹痛，跌扑损伤，痈疽疮疡。
葛根【来源】 本品为豆科植物野葛Pueraria lobata （Willd.）Ohwi或甘葛藤Pueraria thomsonii Benth.的干燥根。【性味】 甘、辛，凉。
【归经】 归脾、胃经。【功能主治】 解肌退热，生津，透疹，升阳止泻。用于外感发热头痛、项背强痛，口渴，消渴，麻疹不透，热痢，泄泻；高血压颈项强痛。
熟地黄【来源】 本品为玄参科植物地黄Rehmannia glutinosa Libosch. 的新鲜或干燥块根。炮制：本品为生地黄的炮制加工品。【性味】 甘，微温。【归经】 归肝、肾经。【功能主治】 滋阴补血，益精填髓。用于肝肾阴虚，腰膝酸软，骨蒸潮热，盗汗遗精，内热消渴，血虚萎黄，心悸怔忡，月经不调，崩漏下血，眩晕，耳鸣，须发早白。
桃仁【来源】 本品为蔷薇科植物桃Prunus persica （L.） Batsch 或山桃 Prunus davidiana （Carr.）Franch.的干燥成熟种子。【性味】 苦、甘，平。【归经】 归心、肝、大肠经。【功能主治】 活血祛瘀，润肠通便。用于经闭，痛经，癓瘕痞块，跌扑损伤，肠燥便秘。
红花【来源】 本品为菊科植物红花Carthamus tinctorius L.的干燥花。【性味】 辛，温。【归经】 归心、肝经。【功能主治】 活血通经，散瘀止痛。用于经闭，痛经，恶露不行，症瘕痞块，跌扑损伤，疮疡肿痛。
桂枝【来源】 本品为樟科植物肉桂 Cinnamomum cassia Presl的干燥嫩枝。【性味】 辛、甘，温。【归经】 归心、肺、膀胱经。【功能主治】 发汗解肌，温通经脉，助阳化气，平冲降气。用于风寒感冒，脘腹冷痛，血寒经闭，关节痹痛，痰饮，水肿，心悸，奔豚。
土鳖虫【来源】 本品为鳖蠊科昆虫地鳖Eupolyphaga sinensis Walker 或冀地鳖Steleophaga plancyi（Boleny）的雌虫干燥体。【性味】 咸，寒；有小毒。【归经】 归肝经。【功能主治】 破瘀血，续筋骨。用于筋骨折伤，瘀血经闭，症瘕痞块。
杜仲【来源】 药材基源：为杜仲科植物杜仲的叶。【性味】 微辛，性温。【归经】入肝，肾经。【功能主治】 补肝肾，强筋骨，降血压。主腰背疼痛，足膝酸软乏力，高血压病。
牛膝【来源】 本品为苋科植物牛膝Achyranthes bidentata Blume. 的干燥根。【性味】 苦、酸，平。【归经】 归肝、肾经。【功能主治】 补肝肾，强筋骨，逐瘀通经，引血下行。用于腰膝酸痛，筋骨无力，经闭症瘕，肝阳眩晕。
桑寄生【来源】 本品为桑寄生科植物桑寄生Taxillus chinensis （DC.）Danser 的干燥带叶茎枝。【性味】 苦、甘，平。【归经】 归肝、肾经。【功能主治】 补肝肾，强筋骨，祛风湿，安胎元。用于风湿痹痛，腰膝酸软，筋骨无力，崩漏经多，妊娠漏血，胎动不安；高血压。
桔梗【来源】 本品为桔梗科植物桔梗Platycodon grandiflorum（Jacq.）A.DC.的干燥根。【性味】 苦、辛，平。【归经】 归肺经。【功能主治】 宣肺，利咽，祛痰，排脓。用于咳嗽痰多，胸闷不畅，咽痛，音哑，肺痈吐脓，疮疡脓成不溃。
甘草【来源】 本品为豆科植物甘草 Glycyrrhiza uralensis Fisch.、胀果甘草 Glycyrrhiza inflata Bat. 或光果甘草 Glycyrrhiza glabra L. 的干燥根。【性味】 甘，平。【归经】 归心、肺、脾、胃经 。【功能主治】 补脾益气，清热解毒，祛痰止咳，缓急止痛，调和诸药。用于脾胃虚弱，倦怠乏力，心悸气短，咳嗽痰多，脘腹、四肢挛急疼痛，痈肿疮毒，缓解药物毒性、烈性。
炒白芍【来源】 本品为毛茛科植物芍药Paeonia lactiflora Pall. 的干燥根。炒白芍：取净白芍片，锅内炒至微黄色。【性味】 苦、酸，微寒。【归经】 归肝、脾经。【功能主治】 平肝止痛，养血调经，敛阴止汗。用于头痛眩晕，胁痛，腹痛，四肢挛痛，血虚萎黄，月经不调，自汗，盗汗。
牡蛎【来源】 本品为牡蛎科动物长牡蛎Ostrea gigas Thunberg、大连湾牡蛎Ostrea talienwhanensis Crosse 或近江牡蛎Ostrea rivularis Gould的贝壳。【性味】 咸，微寒。【归经】 归肝、胆、肾经。【功能主治】 重镇安神，潜阳补阴，软坚散结。用于惊悸失眠，眩晕耳鸣，瘰疬痰核，症瘕痞块。
蜈蚣【来源】 本品为蜈蚣科动物少棘巨蜈蚣Scolopendra subspinipes mutilans L. Koch的干燥体。【性味】 辛，温；有毒。【归经】 归肝经。【功能主治】 息风镇痉，功毒散结，通络止痛。用于小儿惊风，抽搐痉挛，中风口歪，半身不遂，破伤风，风湿顽痹，疮疡，瘰疬，毒蛇咬伤。
山茱萸【来源】 本品为山茱萸科植物山茱萸Cornus officinalis Sieb. et Zucc. 的干燥成熟果肉。【性味】 酸、涩，微温。【归经】 归肝、肾经。【功能主治】 补益肝肾，涩精固脱。用于眩晕耳鸣，腰膝酸痛，阳痿遗精，遗尿尿频，崩漏带下，大汗虚脱。内热消渴。
薏苡仁【来源】 本品为禾本科植物薏苡Coix lacryma-jobi L. var. ma-yuen （Roman.）Stapf的干燥成熟种仁。【性味】 甘、淡，凉。【归经】 归脾、胃、肺经。【功能主治】 健脾渗湿，除痹止泻，清热排浓。用于水肿，脚气，小便不利，湿痹拘挛，脾虚泄泻，肺痈，肠痈；扁平疣。
伸筋草【来源】 本品为石松科植物石松Lycopodium japonicum Thunb. 的干燥全草。【性味】 微苦、辛，温。【归经】 归肝、脾、肾经。【功能主治】 祛风除湿，舒筋活络。用于关节酸痛，屈伸不利。
鸡血藤【来源】 本品为豆科植物密花豆（大血藤、血风藤、三叶鸡血藤、九层风）Spatholobus suberectus Dunn 的干燥藤茎。【性味】 苦、甘，温。【归经】 归肝、肾经。【功能主治】 补血，活血，通络。用于月经不调，血虚萎黄，麻木瘫痪，风湿痹痛。
中医认为：指肾阳不足，命门火衰，火不生土则脾失健运，清浊不分，气机升降失调，脾失温煦，运化失职，成为脾肾两脏阳气俱虚而致的泄泻。患者表现为形寒肢冷，腰膝酸软，大便稀溏，完谷不化，形体消瘦，神疲纳呆，面色少华，或面目虚浮，四肢欠温，舌淡苔白，脉细无力。本发明的采用适宜的中药，各种药物之产是相互配合，协调作用，所制得的中药具有温肾健脾，温阳固涩止泻的功效，能有效治疗脾肾两虚证型泄泻病，五年来，通过对168名患者的使用表明，有效率达94%，治疗效果好，愈后不再复发。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2008年4月-2013年5月间共收集了168例脾肾两虚证型泄泻病门诊患者，其中，男92例，女76例，年龄29-58岁，病情半个月-3年。随机分为：治疗组100例，对照组68例。两组年龄等资料无显著性差异，具有可比性。
2、试验方法
2.1对照组口服四神丸，按照说明书服用。疗程7天。
2.2治疗组口服本发明按照具体实施例1制得的胶囊，早、中、晚各一次。疗程7天。
3、疗效标准及治疗结果
3.1疗效标准：
痊愈：临床症状全部消失，试验室检查正常。好转：临床症状减轻，病情得到控制，实验检查改善或正常。无效：临床症状无明显好转或加重。
3.2治疗统计结果见表1。
表1 两组疗效比较
| 组别 | n | 痊愈 | 好转 | 无效 | 总有效率（%） |
| 治疗组 | 100 | 32 | 62 | 6 | 94% |
| 空白组 | 68 | 9 | 30 | 29 | 57.4% |
由此可见，本发明制得的药物能够安全有效治疗脾肾两虚证型泄泻病。
具体实施方式
为了更好地理解与实施本发明，下面结合具体实施例进一步说明本发明。
具体实施例1
称取黄芪30克、当归15克、葛根24克、熟地黄30克、桃仁10克、红花20克、桂枝20克、土鳖虫10克、杜仲10克、牛膝15克、桑寄生15克、桔梗10克、甘草6克、炒白芍30克、牡蛎30克、蜈蚣1条、山茱萸15克、薏苡仁30克、伸筋草30克、鸡血藤30克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，装入胶囊壳，即得符合正常成人1天用量的胶囊剂。
用于治疗脾肾两虚证型泄泻病。口服，每日分早、中、晚三次服用。
具体实施例2
称取黄芪30克、当归15克、葛根24克、熟地黄30克、桃仁10克、红花20克、桂枝20克、土鳖虫10克、杜仲10克、牛膝15克、桑寄生15克、桔梗10克、甘草6克、炒白芍30克、牡蛎30克、蜈蚣1条、山茱萸15克、薏苡仁30克、伸筋草30克、鸡血藤30克，加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，包装，即得符合正常成人1天用量的散剂。
用于治疗脾肾两虚证型泄泻病。口服，每日分早、中、晚三次服用。
具体实施例3
称取黄芪30克、当归15克、葛根24克、熟地黄30克、桃仁10克、红花20克、桂枝20克、土鳖虫10克、杜仲10克、牛膝15克、桑寄生15克、桔梗10克、甘草6克、炒白芍30克、牡蛎30克、蜈蚣1条、山茱萸15克、薏苡仁30克、伸筋草30克、鸡血藤30克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，再加入适量糊精和矫味剂，按照本领域常规工艺制粒，包装，即得符合正常成人1天用量的颗粒剂。
用于治疗脾肾两虚证型泄泻病。口服，每日分早、中、晚三次服用。
Claims (1)
1.一种治疗脾肾两虚证型泄泻病的中药，其特征是由下列重量配比的原料制成的：黄芪30份、当归15份、葛根24份、熟地黄30份、桃仁10份、红花20份、桂枝20份、土鳖虫10份、杜仲10份、牛膝15份、桑寄生15份、桔梗10份、甘草6份、炒白芍30份、牡蛎30份、蜈蚣1条、山茱萸15份、薏苡仁30份、伸筋草30份、鸡血藤30份。
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| CN108434420A (zh) * | 2018-05-03 | 2018-08-24 | 甘肃中医药大学 | 一种用于治疗结直肠癌术后泄泻的中药制剂 |
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| CN1457831A (zh) * | 2003-04-18 | 2003-11-26 | 侯增光 | 经络血管动力药 |
| CN101703692A (zh) * | 2009-11-05 | 2010-05-12 | 卢速江 | 一种治疗骨伤的中药制剂及其制备方法 |
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| CN1457831A (zh) * | 2003-04-18 | 2003-11-26 | 侯增光 | 经络血管动力药 |
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| CN108434420A (zh) * | 2018-05-03 | 2018-08-24 | 甘肃中医药大学 | 一种用于治疗结直肠癌术后泄泻的中药制剂 |
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