CN103550326B - 一种治疗慢性盆腔炎的药剂的制备方法 - Google Patents
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Abstract
本发明涉及一种治疗慢性盆腔炎的药剂的制备方法，该方法包括下列步骤：取三十六荡80克、上树鳖60克、密花草50克、绢毛菊40克、铁栏杆80克、捆仙丝90克、桃儿七50克、珠子参60克、柞树皮50克和花楸果70克，加入水5000毫升，在90℃下加热5小时，过滤，滤液蒸干，粉碎，过60目筛，加入200克半合成脂肪酸甘油酯，搅拌，在水浴上加热熔融，在混合均匀后加入100个中空栓剂模具中，冷却后，制得100粒栓剂。本发明所述的栓剂的全部成分都是天然材料，安全性较好，疗效明确，适于在临床上大规模推广。
Description
技术领域
本发明涉及妇科领域，具体来说涉及一种治疗慢性盆腔炎的药剂的制备方法。
背景技术
慢性盆腔炎是发生于女性内生殖器及其周围结缔组织和盆腔腹膜的慢性炎症，患者常表现为不同程度的慢性腹痛、月经紊乱、白带增多、不孕、腰痛，伴有或不伴有慢性附件炎。是临床常见病，具有病程长，病情易反复等特点，严重影响患者生活和健康。为了进一步提高治疗效率，缩短病。
发明内容
本发明的目的是提供一种治疗慢性盆腔炎的药剂的制备方法。
为了实现本发明的目的，本发明提供一种治疗慢性盆腔炎的药剂的制备方法，该方法包括下列步骤：取三十六荡80克、上树鳖60克、密花草50克、绢毛菊40克、铁栏杆80克、捆仙丝90克、桃儿七50克、珠子参60克、柞树皮50克和花楸果70克，加入水5000毫升，在回流的条件下加热5小时，过滤，滤液蒸干，粉碎，过60目筛，加入200克半合成脂肪酸甘油酯，搅拌，在水浴上加热熔融，在混合均匀后加入100个中空栓剂模具中，冷却后，制得本发明的100粒栓剂。
更优选地，所述药剂可以是片剂、分散片、胶囊剂或栓剂。
本发明所述的栓剂的全部成分都是天然材料，安全性较好，疗效明确，适于在临床上大规模推广。
附图说明
参照《中药大辞典》第二版，本发明中使用的原料药说明如下：
图1是三十六荡的说明；
图2是上树鳖的说明；
图3是密花草的说明；
图4是绢毛菊的说明；
图5是铁栏杆的说明；
图6是捆仙丝的说明；
图7是桃儿七的说明；
图8是珠子参的说明；
图9是柞树皮的说明；
图10是花楸果的说明。
具体实施方式
下面通过实施例进一步说明本发明。应该理解的是，本发明的实施例是用于说明本发明而不是对本发明的限制。根据本发明的实质对本发明进行的简单改进都属于本发明要求保护的范围。除非另有说明，否则本发明中的百分数是重量百分数。
实施例本发明的栓剂
取三十六荡80克、上树鳖60克、密花草50克、绢毛菊40克、铁栏杆80克、捆仙丝90克、桃儿七50克、珠子参60克、柞树皮50克和花楸果70克，加入水5000毫升，在回流的条件下加热5小时，过滤，滤液蒸干，粉碎，过60目筛，加入200克半合成脂肪酸甘油酯，搅拌，在水浴上加热熔融，在混合均匀后加入100个中空栓剂模具中，冷却后，制得本发明的100粒栓剂。
实验例
临床资料
本组50例患者均为就诊的慢性盆腔炎患者，年龄18-50岁，平 均年龄(28.4±12.6)岁；病程6-45个月，平均(25.2±18.7)月。入选标准：(1)年龄18-50岁；(2)肝肾功能正常；(3)无内科治疗禁忌症；(4)能正常交流，并签署知情同意书。排除标准：(1)年龄<18岁或者>50岁；(2)合并急性生殖系统炎症；(3)肝肾功能异常；(4)妊娠、哺乳期患者；(5)对所应用药物过敏；(6)中断治疗和随访者。
诊断标准
参照《中药新药临床研究指导原则》制订。症状：下腹及腰痛，下腹坠胀，腰骸部酸痛，常在劳累、性交后、排便时及月经前后加重，可伴有低热、月经增多和白带增多。妇科检查：子宫常呈后位，活动受限或粘连固定，输卵管炎时在子宫一侧或两侧可触及条索状物，并有轻压痛；盆腔结缔组织发炎时，子宫一侧或两侧有片状增厚、压痛；或在盆腔一侧或两侧摸到包块。
使用实施例1中制得的栓剂来进行治疗，每天1次，每次1粒，治疗两周为一个疗程。
疗效标准
参照《中药新药临床研究指导原则》制订。痊愈：症状、体征消失，妇科检查正常；显效：症状消失，妇科检查有显著性改善；有效：症状、体征及检查均有减轻；无效：治疗后无改善。
经过一个疗程的观察，发现全部患者症状、体征消失，妇科检查正常，均符合痊愈的治疗标准。
不良反应和毒副作用监管
在治疗过程中，通过检测患者的血压、脉搏、是否出现恶心、呕吐、眩晕的临床症状来判断不良反应。发现50例患者的收缩压为 90-140mmHg，舒张压60-90mmHg，脉搏为60-100次／每分钟，血压和脉搏全部都在正常范围内，并且没有出现恶心、呕吐、眩晕的临床症状，患者意识清醒，经询问并无任何不适。在治疗后随访一月，未发现患者出现任何异常，生活正常，这说明本发明的药物组合物没有明显的不良反应，进而证明该药物对于人体没有明显的毒副作用。
Claims (1)
1.一种治疗慢性盆腔炎的药剂的制备方法，其特征在于，该方法包括下列步骤：取三十六荡80克、上树鳖60克、密花草50克、绢毛菊40克、铁栏杆80克、捆仙丝90克、桃儿七50克、珠子参60克、柞树皮50克和花楸果70克，加入水5000毫升，在90℃下加热5小时，过滤，滤液蒸干，粉碎，过60目筛，加入200克半合成脂肪酸甘油酯，搅拌，在水浴上加热熔融，在混合均匀后加入100个中空栓剂模具中，冷却后，制得100粒栓剂。
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103120775A (zh) * | 2013-03-02 | 2013-05-29 | 刘长美 | 一种治疗慢性盆腔炎的中药制剂 |
| CN103330793A (zh) * | 2013-07-05 | 2013-10-02 | 孔庆芹 | 一种治疗慢性盆腔炎的中药灌肠剂 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103120775A (zh) * | 2013-03-02 | 2013-05-29 | 刘长美 | 一种治疗慢性盆腔炎的中药制剂 |
| CN103330793A (zh) * | 2013-07-05 | 2013-10-02 | 孔庆芹 | 一种治疗慢性盆腔炎的中药灌肠剂 |
Non-Patent Citations (1)
| Title |
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| 南京中医药大学.中药大辞典.《中药大辞典 上下册》.上海科学技术出版社,2006,(第2版),第91-92、216、3164、2793、2612、2568、2545、2546、2475、2236、1477页各对应药物项下. * |
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