CN103536755B - A kind of preparation method for the treatment of the decoction of knee joint osseous arthritis - Google Patents
A kind of preparation method for the treatment of the decoction of knee joint osseous arthritis Download PDFInfo
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- CN103536755B CN103536755B CN201310475734.0A CN201310475734A CN103536755B CN 103536755 B CN103536755 B CN 103536755B CN 201310475734 A CN201310475734 A CN 201310475734A CN 103536755 B CN103536755 B CN 103536755B
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- 210000000629 knee joint Anatomy 0.000 title claims abstract description 30
- 206010003246 arthritis Diseases 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 241001533451 Ajuga ciliata Species 0.000 claims abstract description 4
- 241000903946 Clematidis Species 0.000 claims abstract description 4
- 241000628997 Flos Species 0.000 claims abstract description 4
- 239000000706 filtrate Substances 0.000 claims abstract description 4
- 238000007789 sealing Methods 0.000 claims abstract description 4
- 210000000582 semen Anatomy 0.000 claims abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 4
- 230000000694 effects Effects 0.000 abstract description 6
- 238000000034 method Methods 0.000 abstract description 4
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 208000002193 Pain Diseases 0.000 description 9
- 230000036407 pain Effects 0.000 description 9
- 230000008407 joint function Effects 0.000 description 7
- 208000006820 Arthralgia Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 239000003814 drug Substances 0.000 description 4
- 208000035475 disorder Diseases 0.000 description 3
- 238000007689 inspection Methods 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 206010020880 Hypertrophy Diseases 0.000 description 2
- 210000001188 articular cartilage Anatomy 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 210000003141 lower extremity Anatomy 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 230000002688 persistence Effects 0.000 description 2
- 208000037920 primary disease Diseases 0.000 description 2
- 210000005065 subchondral bone plate Anatomy 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 206010065564 Floating patella Diseases 0.000 description 1
- 241000521257 Hydrops Species 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 201000000023 Osteosclerosis Diseases 0.000 description 1
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- 238000001467 acupuncture Methods 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- -1 analgesia Substances 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940124599 anti-inflammatory drug Drugs 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- 230000002917 arthritic effect Effects 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 210000001612 chondrocyte Anatomy 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
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- 239000000835 fiber Substances 0.000 description 1
- 239000003862 glucocorticoid Substances 0.000 description 1
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Abstract
The present invention relates to a kind of preparation method for the treatment of the decoction of knee joint osseous arthritis, its the following step: take Rhizoma Paridis 50 grams, Cortex Dictamni 100 grams, Radix Polygoni Ciliinerve 100 grams, Radix Ophiopogonis 50 grams, Folium Isatidis 100 grams, Herba Rabdosiae Lophanthoidis 50 grams, Radix Polygalae 50 grams, Semen Raphani 50 grams, Flos Lonicerae 100 grams, Herba Leonuri 150 grams, Radix Tripterygii Wilfordii 150 grams, Radix Rhapontici 300 grams, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 100 grams, Cortex Mori 250 grams, Radix Clematidis 200 grams, Rhizoma Alismatis 50 grams and 5000 grams, water, be placed in the flask of sealing, heat 5 hours under the water-bath of 90 DEG C, be cooled to room temperature, filter, collect filtrate and namely obtain decoction of the present invention.The decoction of the treatment knee joint osseous arthritis that the method for the invention obtains has the advantages that cost is low, preparation is easy, toxic and side effects is little, curative effect shows.
Description
The divisional application that the present invention is the applying date is on November 14th, 2012, application number is 2012104529852, denomination of invention is the invention of " a kind of decoction for the treatment of knee joint osseous arthritis "
Technical field
The present invention relates to field of orthopaedics, relate in particular to a kind of preparation method for the treatment of the decoction of knee joint osseous arthritis.
Background technology
Knee joint osseous arthritis is the commonly encountered diseases of Orthopaedics Clinic, and clinical manifestation is kneed swelling, pain, and can there be joint deformity in the later stage, patient's walking, upper downstairs, difficulty of having squatted, quality of life is had a strong impact on.Primary disease more than 60 years old crowd has 49% generation primary disease, and women's prevalence is higher than male.The pathogenic factor more complicated of knee joint osseous arthritis, mainly comprise the stress equilibrium imbalance etc. of wound, obesity, age, over loading motion, sex, environment, biomechanics aspect, wherein, middle-aged and elderly people is principal pathogenetic colony.Its basic pathology is changed to that articular cartilage is softened, the spasm of osteosclerosis, synovitis, Secondary cases joint capsule fibre modification and Surrounding muscles under cartilage surface.Past expectant treatment mainly with oral antipyretic, analgesia, anti-inflammatory drug, or intraarticular injection glucocorticoid medicine, though there is certain clinical efficacy, but paresthesia alleviateding time is short, as its untoward reaction of prolonged application is difficult to again avoid, especially intraarticular injection, puncture frequently and easily cause infecting, more easily cause chondrocyte to destroy, thus be unfavorable for the reparation of articular cartilage, the arthritic development process of accelerated bone.Therefore, in the urgent need to finding a kind of medicament for the treatment of knee joint osseous arthritis.
Summary of the invention
The object of this invention is to provide a kind of preparation method for the treatment of the decoction of knee joint osseous arthritis.
In order to realize object of the present invention, the invention provides a kind of preparation method for the treatment of the decoction of knee joint osseous arthritis, its the following step: take Rhizoma Paridis 50 grams, Cortex Dictamni 100 grams, Radix Polygoni Ciliinerve 100 grams, Radix Ophiopogonis 50 grams, Folium Isatidis 100 grams, Herba Rabdosiae Lophanthoidis 50 grams, Radix Polygalae 50 grams, Semen Raphani 50 grams, Flos Lonicerae 100 grams, Herba Leonuri 150 grams, Radix Tripterygii Wilfordii 150 grams, Radix Rhapontici 300 grams, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 100 grams, Cortex Mori 250 grams, Radix Clematidis 200 grams, Rhizoma Alismatis 50 grams and 5000 grams, water, be placed in the flask of sealing, heat 5 hours under the water-bath of 90 DEG C, be cooled to room temperature, filter, collect filtrate and namely obtain decoction of the present invention.
The decoction of the treatment knee joint osseous arthritis that the method for the invention obtains has the advantages that cost is low, preparation is easy, toxic and side effects is little, curative effect shows.
Detailed description of the invention
Below by way of the description of detailed description of the invention, the invention will be further described, but this is not limitation of the present invention, those skilled in the art are according to basic thought of the present invention, various amendment or improvement can be made, but only otherwise depart from basic thought of the present invention, all within the scope of the present invention.
Embodiment 1: the preparation of decoction of the present invention
Take Rhizoma Paridis 50 grams, Cortex Dictamni 100 grams, Radix Polygoni Ciliinerve 100 grams, Radix Ophiopogonis 50 grams, Folium Isatidis 100 grams, Herba Rabdosiae Lophanthoidis 50 grams, Radix Polygalae 50 grams, Semen Raphani 50 grams, Flos Lonicerae 100 grams, Herba Leonuri 150 grams, Radix Tripterygii Wilfordii 150 grams, Radix Rhapontici 300 grams, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 100 grams, Cortex Mori 250 grams, Radix Clematidis 200 grams, Rhizoma Alismatis 50 grams and 5000 grams, water, be placed in the flask of sealing, heat 5 hours under the water-bath of 90 DEG C, be cooled to room temperature, filter, collect filtrate and namely obtain decoction of the present invention.
Experimental example
Diagnosis basis
1. the gonalgia, is often persistence dull pain, generally increases the weight of after exercise, alleviate after rest.2. knee joint often has deadlocked phenomenon, namely rests on some positions for a long time, has a kind of stiff sense during motion, takes a turn for the better, and have the phenomenon of soft lower limb for falling after movable.3. knee joint function is slight or moderate is limited, walking disorder, difficulty of squatting down.4. the person that has hydrops, floating patella test is positive.5. x-ray knee joint anterioposterior and lateral film shows: joint space narrows, subchondral bone matter edge hypertrophy, or joint margins has bony spur to be formed.6. lab testing: rheumatoid factor negative, erythrocyte sedimentation rate, antistreptolysin O normal (Zhu Hanzhang. pin cutter medical science. Beijing: China Traditional Chinese Medicine Publishing House, 2004:538-540.).
Physical data
Choosing the patient's physical data meeting above-mentioned standard originally organizes in 84 examples, man 35 example, female 49 example, age 37-78 year, 56.2 years old mean age.The course of disease is the shortest 3 months, the longest 1 year, bilateral knee joint 32 example, unilateral knee joint 52 example, above patient all through medicine, acupuncture, massage, the method such as to force on treatment, poor effect.
Take the decoction of preparation in embodiment 1, three times on the one, each 100 milliliters.It within 30 days, is 1 course for the treatment of.
The standard of curative effect evaluation
Cure: transference cure after treatment, pressure pain point disappears, and knee joint function recovers normal.Effective: treatment posterior joint pain, stiff and swelling situation obviously alleviate, and function recovers normal substantially.Effective: treatment posterior joint pain, stiff and swelling situation alleviate, but still pain, and function is slightly limited.Invalid: after treatment, symptom compares without improving with preoperative.
Through treatment, find the transference cure of 84 examples, pressure pain point disappears, and knee joint function recovers normal.Therefore, the standard of healing is all met.And do not find obvious untoward reaction over the course for the treatment of.
Typical pathologic
Sui, female, 37 years old, left knee joint persistence dull pain, increased the weight of after exercise, alleviates after rest.X-ray knee joint anterioposterior and lateral film shows subchondral bone matter edge hypertrophy.On inspection, confirm as knee joint osseous arthritis.Take the decoction of preparation in embodiment 1, three times on the one, each 100 milliliters, continuously treatment 30 days.The transference cure of patient after treatment, pressure pain point disappears, and knee joint function recovers normal.
Zhang, man, 41 years old, two knee joints often had deadlocked phenomenon, rested on some positions for a long time, had a kind of stiff sense during motion, take a turn for the better, and have the phenomenon of soft lower limb for falling, walking disorder, difficulty of squatting down, the gonalgia after movable.On inspection, confirm as knee joint osseous arthritis.Take the decoction of preparation in embodiment 1, three times on the one, each 100 milliliters, continuously treatment 30 days.The transference cure of patient after treatment, pressure pain point disappears, and knee joint function recovers normal.
King so-and-so, female, 51 years old, knee joint function was slight or moderate is limited, walking disorder, difficulty of squatting down, the gonalgia.On inspection, confirm as knee joint osseous arthritis.Take the decoction of preparation in embodiment 1, three times on the one, each 100 milliliters, continuously treatment 30 days.The transference cure of patient after treatment, pressure pain point disappears, and knee joint function recovers normal.
Claims (1)
1. treat the preparation method of the decoction of knee joint osseous arthritis for one kind, it is characterized in that it comprises the following steps: to take Rhizoma Paridis 50 grams, Cortex Dictamni 100 grams, Radix Polygoni Ciliinerve 100 grams, Radix Ophiopogonis 50 grams, Folium Isatidis 100 grams, Herba Rabdosiae Lophanthoidis 50 grams, Radix Polygalae 50 grams, Semen Raphani 50 grams, Flos Lonicerae 100 grams, Herba Leonuri 150 grams, Radix Tripterygii Wilfordii 150 grams, Radix Rhapontici 300 grams, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 100 grams, Cortex Mori 250 grams, Radix Clematidis 200 grams, Rhizoma Alismatis 50 grams and 5000 grams, water, be placed in the flask of sealing, heat 5 hours under the water-bath of 90 DEG C, be cooled to room temperature, filter, collect filtrate and namely obtain described decoction.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210452985.2A CN102908510B (en) | 2012-11-14 | 2012-11-14 | Decoction for treating knee osteoarthritis |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210452985.2A Division CN102908510B (en) | 2012-11-14 | 2012-11-14 | Decoction for treating knee osteoarthritis |
Publications (2)
| Publication Number | Publication Date |
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| CN103536755A CN103536755A (en) | 2014-01-29 |
| CN103536755B true CN103536755B (en) | 2015-11-25 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201210452985.2A Expired - Fee Related CN102908510B (en) | 2012-11-14 | 2012-11-14 | Decoction for treating knee osteoarthritis |
| CN201310475734.0A Expired - Fee Related CN103536755B (en) | 2012-11-14 | 2012-11-14 | A kind of preparation method for the treatment of the decoction of knee joint osseous arthritis |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201210452985.2A Expired - Fee Related CN102908510B (en) | 2012-11-14 | 2012-11-14 | Decoction for treating knee osteoarthritis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103656529B (en) * | 2013-12-23 | 2015-10-28 | 傅晓倩 | One treats cirsoid External-applicationtraditional traditional Chinese medicinal |
| CN103720839B (en) * | 2014-01-20 | 2015-04-08 | 张龙强 | Traditional Chinese medicine for treating knee osteoarthritis |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1618448A (en) * | 2003-11-19 | 2005-05-25 | 北京双鹤药业股份有限公司 | Medicine composition for treating osseous arthritis, and its prepn. method |
| CN102327380A (en) * | 2011-10-22 | 2012-01-25 | 李进峰 | Chinese medicinal composition for treating knee osteoarthritis |
| CN102579634A (en) * | 2012-02-23 | 2012-07-18 | 熊桂华 | Externally applied traditional Chinese medicine composition for treating knee osteoarthritis (OA) |
-
2012
- 2012-11-14 CN CN201210452985.2A patent/CN102908510B/en not_active Expired - Fee Related
- 2012-11-14 CN CN201310475734.0A patent/CN103536755B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1618448A (en) * | 2003-11-19 | 2005-05-25 | 北京双鹤药业股份有限公司 | Medicine composition for treating osseous arthritis, and its prepn. method |
| CN102327380A (en) * | 2011-10-22 | 2012-01-25 | 李进峰 | Chinese medicinal composition for treating knee osteoarthritis |
| CN102579634A (en) * | 2012-02-23 | 2012-07-18 | 熊桂华 | Externally applied traditional Chinese medicine composition for treating knee osteoarthritis (OA) |
Non-Patent Citations (1)
| Title |
|---|
| 清热解毒法治疗活动性类风湿性关节炎概况;周海蓉等;《山东中医药大学学报》;19990520;第23卷(第03期);228-231 * |
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| Publication number | Publication date |
|---|---|
| CN103536755A (en) | 2014-01-29 |
| CN102908510A (en) | 2013-02-06 |
| CN102908510B (en) | 2014-01-15 |
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