CN102949634B - Traditional Chinese medicine for treating cervical spondylosis, lumbar disc herniation and scapulohumeral periarthritis and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine for treating cervical spondylosis, lumbar disc herniation and scapulohumeral periarthritis and a preparation method thereof. The main ingredients of the traditional Chinese medicine for treating the cervical spondylosis, the lumbar disc herniation and the scapulohumeral periarthritis disclosed by the invention are as follows: clematis intricata, lycopodium clavatum, radix clematidis, erythrina indica lam, cortex acanthopanacis, drynaria rhizome, rhizoma sparganii and daemonorops draco. The traditional Chinese medicine is prepared into various preparations in common use according to a traditional technology for the traditional Chinese medicine. The traditional Chinese medicine disclosed by the invention fully reflects a therapeutic principle of the diagnosis and treatment based on syndrome differentiation of traditional Chinese medical science; the composition is scientific and reasonable; the raw materials are easily and conveniently obtained; the traditional Chinese medicine is economical and applicable; the property of the medicine is stable; the effect is comprehensive; the traditional Chinese medicine has better curative effect for the diseases such as the cervical spondylosis, the lumbar disc herniation, the scapulohumeral periarthritis, and osteoarthritis; and after ligusticum wallichii, radix angelicae, pawpaw and borneol are added, the curative effect for the diseases is better.

Description

Chinese medicine for the treatment of cervical spondylosis, prolapse of lumbar intervertebral disc, scapulohumeral periarthritis and preparation method thereof

Technical field

The present invention relates to field of medicaments, be specifically related to a kind of Chinese medicine for the treatment of cervical spondylosis, prolapse of lumbar intervertebral disc, scapulohumeral periarthritis and preparation method thereof.

Background technology

Cervical spondylosis refers to because cervical vertebra degeneration causes cervical spinal canal or intervertebral foramina distortion, narrow, stimulates, compressing cervical spinal cord, nerve root, and causes the disease of corresponding clinical symptoms, and this disease is more common in more than 40 years old patient.Cervical spondylosis refers to that the plump hypertrophy of degeneration of cervical intervertebral disc, cervical vertebra and neck injury etc. cause hyperosteogeny of cervical vertebra, or prolapse of intervertebral disc, ligament thicken, and stimulates or compressing cervical spinal, cervical region nerve, blood vessel and produce the clinical syndrome of series of symptoms.Main manifestations is neck and shoulder pain, dizziness headache, upper limb numbness, amyotrophy, the two lower limb spasm of severe patient, difficulty in walking, even quadriplegia, and, there is paralysis in defecation obstacle.Multiple at middle-aged and elderly people, male's sickness rate is higher than women.

In the developing of cervical spondylosis, chronic strain is primary arch-criminal, the damage of local muscle for a long time, ligament, joint capsule, can cause local hemorrhage edema, change is inflamed, engender inflammation machine at the position of pathological changes, and form hyperosteogeny, affect local nerve and blood vessel.Wound is the pathogenetic direct factor of cervical vertebra.Often, had pathological changes in various degree wound forefathers, made cervical vertebra in highly dangerous state, the direct induced symptom of wound occurs.Bad posture is other one large reason of cervical spine injury.The work of bowing for a long time, lies on a bed and sees TV, reading, likes high pillow, long-time operation computer, and violent rotation cervical region or head are slept on the car travelling, and these bad postures all can make musculi colli in long-term fatigue state, easily damage.The dysplasia of cervical vertebra or defect are also one of cervical spondylosis generation assignable causes, and ethnic group vertebral canal volume with respect to occidentals in Asia is less, and compression of spinal cord more easily occurs, and produce symptom.One-sided vertebral artery lack as patient, the incidence rate of vertebral artery type of cervical spondylosis is almost 100%, the sooner or later of difference.In addition, basilar impression, congenitally melt that vertebra, root pipe are narrow, little canalis spinalis etc. is all congenital dysplasias, is also this pathogenetic major reason.

Oral drug therapy is mainly used in alleviating pain, local antiinflammatory, the treatment that relaxs one's muscles, clearer and more definite for curative effects such as the local soft tissue strains of the secondary such as cervical vertebra shakiness, but can not fundamentally treat cervical spondylosis.For with myasthenia of limbs or numb patient, can also use neurotrophy medicine recovering aid, promote the recovery of pressurized nerve.

Clear and definite to diagnosis cervical spondylosis, nerve root compression symptom is serious, after expectant treatment, symptom should be taked operative treatment without the person of being clearly better, and for CSM patients, be that main manifestations is the patient of two lower limb symptoms such as unable, walking is unstable on foot, should carry out as early as possible operative treatment, to obtain good recovery effects, because this class patient's therapeutic effect and nerve compression time length have substantial connection.And for the patient of vertebral artery and sympathetic activation type, surgical effect is just not too definite comparatively speaking.

Prolapse of lumbar intervertebral disc is that after Anular disruption, the outstanding pressuring neural root of vertebral pulp causes the disease taking lumbago and skelalgia as main manifestations.Lumbar intervertebral disc is equivalent to an amphiarthrosis, is made up of hyaline cartilage plate, fibrous ring and vertebral pulp, is distributed between lumbar vertebra.Anular disruption due to lumbar intervertebral disc degenerative change or wound, vertebral pulp is deviate from from rent, compressing lumbar vertebra nerve, thus there is waist lower limb radiated pain.

Prolapse of lumbar intervertebral disc is due to lumbar intervertebral disc degeneration, Anular disruption, a series of clinical symptoms and sign that the outstanding stimulation of vertebral pulp or pressuring neural root, cauda equina nerve show, be commonly called as in " waist dash forward disease ", be clinical commonly encountered diseases and cause the topmost reason of lumbago and skelalgia, the normal live and work of giving patient brings many miseries, even causes deformity, disability.Prolapse of lumbar intervertebral disc is the main cause of lumbago and skelalgia, is one of the most common illness of Orthopedic Clinical, accounts for the 10%-15% of Orthopaedics Clinic low back pain, and because of lumbago and skelalgia inpatient's 25%-40%.Prolapse of lumbar intervertebral disc is current frequently-occurring disease, and rehabilitation difficulty is larger, need to change irrational life style.The most common symptom of patients with lumbar disc herniation is pain, can show as lumbago and backache, sciatica, and typical sciatica shows as the radiating pain by buttocks, thigh rear side, shank outside to heel or instep.According to clinical statistics, approximately 95% the prominent disease patient of waist has lumbago in various degree, and 80% patient has leg pain.Particularly lumbago, is not only the modal symptom of prolapse of lumbar intervertebral disc, is also one of symptom occurring the earliest.

Prolapse of lumbar intervertebral disc is one of orthopaedics commonly encountered diseases, and approximately 1/5 lumbago and skelalgia patient is that prolapse of lumbar intervertebral disc causes.This disease is proposed existing more than 70 years so far from Mixterher in 1934 and Barr.From domestic and international Analysis of epidemic disease, population ratio and the absolute figure of its sickness rate are all in rising trend.How old age of onset is from having by tens years old, and we once saw the prolapse of lumbar intervertebral disc patient of 9 years old.This sick sickness rate rises, and the environment of living with us, the custom of live and work change relevant, and long-term bad being accustomed to waist is main cause.

More traditional Chinese medical science external medication prolapse of lumbar intervertebral disc, take and invigorate blood circulation, and pain relieving is changed and become silted up, the network that stimulates the menstrual flow away, has one's ideas straightened out deep, the medicine of expelling wind and cold texts, by returning through effect and conditioning human body equilibrium between yin and yang of medicine, the tip that excites nerve, promotes local blood microcirculation etc.　

The operative treatment of prolapse of lumbar intervertebral disc is to retain bone structure and the soft tissue structure that needn't remove as far as possible, reaches enough appearing with minimum wound, carefully removes up hill and dale pathological tissues, reaches therapeutic purposes.Traditional lumbar discectomy has the methods such as fenestration, semi-vertebral plate excision and laminectomy.Fenestration soft tissue less separation, sclerotin excision limitation, less on spinal stability impact, most of intervertebral disk hernia can adopt the method.Intervertebral disk hernia merges obvious degenerative change, needs to detect more widely or decompression person, can adopt hemilaminectomy.

Lumbar Disc has certain risk, and operation related complication has intraoperative hemorrhage, blood vessel injury, spinal dura mater damage, cauda equina injury, nerve root damage etc.After operation likely there is shock, dark venous thrombosis, dyspnea, pulmonary infection and pulmonary atelectasis, urinary tract infection, the whole body complication such as abdominal distention vomiting in peri-operation period.Need the close observation state of an illness to note abnormalities in time, give rapidly correct processing.

Scapulohumeral periarthritis, full name is scapulohumeral periarthritis, is the shoulder joint soft tissue injury such as muscle, ligament, tendon, synovial bursa, joint capsule, regression and the joint capsule that causes and the chronic aseptic inflammation of one of periarticular soft tissues around.Its clinical manifestation is that onset is slow, and the course of disease is longer, and the course of disease generally, in 1 year, can reach 1-2 compared with elder.Age of onset is most more than 40 years old, and women's sickness rate is a little more than male, and is more common in physical labourer.Because the people of about 50 years old easily suffers from this disease, so primary disease is called again bursitis of shoulder.Scapulohumeral periarthritis motherland medical science is referred to as " scapulohumeral periarthritis ", " congealed shoulder ", " bursitis of shoulder " etc., is taking shoulder arthralgia as main, is first paroxysmal to ache, and then moves a kind of commonly encountered diseases, the frequently-occurring disease of obstacle.Suffer from the patient of scapulohumeral periarthritis, conscious have cold air to enter shoulder, also has patient to feel to have cold air outwards to emerge from shoulder joint inside, therefore claim again " scapulohumeral periarthritis ".Its lesion characteristic is that extensively pain is extensive, function limitation is extensive, tenderness is extensive.

The early stage available blood circulation promoting and blood stasis dispelling of scapulohumeral periarthritis, relaxing muscles and tendons and activating QI and blood in the collateral, the Chinese medicine external of anti-inflammatory analgetic etc. effects, is equipped with acupuncture, cup, scrape therapy and then reaches the object for the treatment of both the principal and secondary aspects of a disease.

Osteoarthritis is a kind of chronic joint disease, and its main change is degeneration and the insecondary hyperosteogeny of articular cartilage face.Main manifestations is arthralgia and movable dumb, and x-ray performance joint space narrows, the densification of subchondral bone matter, and bone trabecula fracture, has sclerosis and cystis degeneration.There is lip sample hypertrophy at edge, joint.Later stage epiphysis distortion, articular surface is uneven.Intraarticular cartilage peels off, and the cracked joint that enters of sclerotin forms articular mobile corpus.Osteoarthritis is named again degenerative osteoarthritis, and actual not inflammation, is mainly degeneration, belongs to the aging of joint premature aging, particularly articular cartilage.Osteoarthritis is representing the aging in joint, thus be referred to as senile arthritis, the degeneration that pathological characteristic is focal articular cartilage, subchondral bone qualitative change close (sclerosis), marginality bone cartilage hyperosteogeny forms and joint deformity.The common site of osteoarthritis comprises hands, knee joint, hip, foot etc.Can there is the pathological changes at a more than position in same patient.

Knee joint osseous arthritis refers to the chronic osteoarthrosis illness of the one causing due to knee cartilage degeneration, hyperosteogeny, is called again gonarthrosis, degenerative osteoarthritis and osseous arthritis etc., also can there is adolescence in the multiple middle-aged and elderly people of being born in of primary disease; Can one-sidedly fall ill, also can bilateral morbidity.

The interior injection of clinical conventional articular cavity hyaluronate sodium. glucosamine, external non-steroidal antalgic anti-inflammatory agent patch can suppress the synthetic of Cycloxygenase and prostaglandin, to anti-inflammatory response, alleviates hydrarthrosis and pain.At present also have a lot of Chinese medicine to be applied among treatment, but curative effect is difficult to evaluate.

To knee joint osteoarthritis, someone advocates arthroscopic cleaning art in advance, and this class operation has certain curative effect to some patient's postoperative short-term, but long-term effect can not be affirmed.Joint replacement surgery is for most of osteoarthritis, femur head necrosis, rheumatoid arthritis people, aspect alleviating pain, recovery function of joint, there is remarkable result, but because joint replacement surgery exists certain recent and long term complication, as loosening and wearing and tearing, the bone of parts dissolve, these complication can't solve at present completely.Therefore the surgical indication of, strictly grasping joint replacement seems very important.

These diseases existing identical ill mechanism and feature, also have mutual difference part, and finding one can all have definite curative effect to these diseases, and uses safety, and the little Chinese medicine of side effect is highly significant.　　

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine for the treatment of cervical spondylosis, prolapse of lumbar intervertebral disc, scapulohumeral periarthritis and preparation method thereof, the reasonable science of Chinese prescription for the treatment of cervical spondylosis provided by the present invention, prolapse of lumbar intervertebral disc, scapulohumeral periarthritis, determined curative effect, side effect is little.

The Chinese medicine for the treatment of cervical spondylosis of the present invention, prolapse of lumbar intervertebral disc, scapulohumeral periarthritis is prepared from by the raw material that comprises following weight portion:

Herba clematidis intricatae 10～40 Herba Lycopodii 10～40 Radix Clematidis 10～40

Cortex erythrinae 10～40 Cortex Acanthopancis 10～40 Rhizoma Drynariae 10～40

Rhizoma Sparganii 10～40 Sanguis Draxonis 1～10.

In above-mentioned raw material composition, can also add the Rhizoma Chuanxiong of 10～40 weight portions, the Radix Angelicae Dahuricae of 10～40 weight portions, the Fructus Chaenomelis of 10～40 weight portions, the Borneolum Syntheticum of 1～6 weight portion, increase curative effect.

The Chinese medicine for the treatment of cervical spondylosis of the present invention, prolapse of lumbar intervertebral disc, scapulohumeral periarthritis, its preferred version is to be prepared from by the raw material that comprises following weight portion:

Herba clematidis intricatae 10～30 Herba Lycopodii 10～30 Radix Clematidis 10～30

Cortex erythrinae 10～30 Cortex Acanthopancis 10～30 Rhizoma Drynariae 10～30

Rhizoma Sparganii 10～30 Sanguis Draxonis 3～8.

In above-mentioned raw material composition, can also add the Rhizoma Chuanxiong of 10～30 weight portions, the Radix Angelicae Dahuricae of 10～30 weight portions, the Fructus Chaenomelis of 10～30 weight portions, the Borneolum Syntheticum of 3～6 weight portions, increase curative effect.

The Chinese medicine for the treatment of cervical spondylosis of the present invention, prolapse of lumbar intervertebral disc, scapulohumeral periarthritis, its further preferred version is to be prepared from by the raw material that comprises following weight portion:

Herba clematidis intricatae 20 Herba Lycopodii 20 Radix Clematidis 20

Cortex erythrinae 20 Cortex Acanthopancis 20 Rhizoma Drynariae 20

Rhizoma Sparganii 20 Sanguis Draxonis 5 Rhizoma Chuanxiongs 15

The Radix Angelicae Dahuricae 15 Fructus Chaenomelis 12 Borneolum Syntheticums 5.

The Chinese medicine for the treatment of cervical spondylosis of the present invention, prolapse of lumbar intervertebral disc, scapulohumeral periarthritis, the active component of its first composition of raw materials is prepared from by the following method:

Get the 8 taste medical materials such as Herba clematidis intricatae, Herba Lycopodii, Radix Clematidis, Cortex erythrinae, Cortex Acanthopancis, Rhizoma Drynariae, Rhizoma Sparganii, Sanguis Draxonis, add and be equivalent to the alcohol dipping 12～48 hours that the volume by volume concentration of 1～2 times of this 8 taste medical material gross weight is 40%～60%, then the ethanol that is 40%～60% with volume by volume concentration carries out percolation with the speed that accounts for raw material total weight parts 0.2%～0.6% per minute, collection is equivalent to the percolate that this 8 taste medical material gross weight 5-10 doubly measures, reclaim ethanol, be evaporated to and be equivalent to 1～2 times of this 8 taste medical material gross weight, filter, obtain active component.

The Chinese medicine for the treatment of cervical spondylosis of the present invention, prolapse of lumbar intervertebral disc, scapulohumeral periarthritis, the active component of its another kind of composition of raw materials is to be prepared from by following method for optimizing:

Get Herba clematidis intricatae, Herba Lycopodii, Radix Clematidis, Cortex erythrinae, Cortex Acanthopancis, Rhizoma Drynariae, Rhizoma Sparganii, Sanguis Draxonis, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, the 11 taste medical materials such as Fructus Chaenomelis, add and be equivalent to the alcohol dipping 12～48 hours that the volume by volume concentration of 1～2 times of this 11 taste medical material gross weight is 40%～60%, then the ethanol that is 40%～60% with volume by volume concentration carries out percolation with the speed that accounts for raw material total weight parts 0.2%～0.6% per minute, collection is equivalent to the percolate that this 11 taste medical material gross weight 5-10 doubly measures, reclaim ethanol, be evaporated to and be equivalent to 1～2 times of this 11 taste medical material gross weight, filter, obtain medicinal liquid A,

Medicinal liquid A and Borneolum Syntheticum are active component.

Described medicinal liquid A can use according to different dosage form technique from Borneolum Syntheticum, is prepared into various common dosage forms.

The Chinese medicine for the treatment of cervical spondylosis of the present invention, prolapse of lumbar intervertebral disc, scapulohumeral periarthritis, can coordinate with pharmaceutically acceptable carrier, makes various common dosage forms.

The Chinese medicine of described treatment cervical spondylosis, prolapse of lumbar intervertebral disc, scapulohumeral periarthritis is as the application of preparation treatment medicine for treating arthritis.

In the present invention, Chinese medicine details is as follows:

Herba clematidis intricatae

This product is the dry herb of ranunculaceae plant Herba clematidis intricatae Clematis intricate Bunge.Acrid in the mouth, warm in nature.Enter lung, spleen two warps.Function wind-damp dispelling; External cures mainly rheumatic arthritis, prurigo, mange.

Herba Lycopodii

This product is the dry herb of lycopsid Lycopodium clavatum Lycopodium japonicum Thunb..Mildly bitter flavor, pungent, warm in nature.Return liver,spleen,kidney warp.Function expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral.For joint aches, joint stuffiness.

Radix Clematidis

This product is the dry root and rhizome of ranunculaceae plant Radix Clematidis Clematis chinensis Osbeck, Clematis hexapetala Clematis hexapetala Pall. or northeast clematis Clematis manshurica Rupr..Mildly bitter flavor, pungent, warm in nature.Return liver,spleen,kidney warp.Function expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral.For joint aches, joint stuffiness.

Cortex erythrinae

This product is the dry bark of leguminous plant erythrina indica Erythrina variegate L.var orientalis (L) Merr or Erythrinae Arborescentis Erythrina arborescens Roxb.Bitter in the mouth, pungent, property is flat.Enter liver, spleen channel.Function wind-damp dispelling, the meridian dredging, parasite killing.Dispelling the wind and dampness pathogens arthralgia pain, dysentery, toothache, scabies.

Cortex Acanthopancis

This product is the dry root bark of Araliaceae acanthopanax gracilistylus Acanthopanax gracilistylus W.W.Smith.Acrid in the mouth, hardship, warm in nature.Return liver, kidney channel.Function expelling wind and removing dampness, liver and kidney tonifying. bone and muscle strengthening, inducing diuresis to remove edema.For Bi condition, muscles and bones flaccidity is soft, youngster's walking retardation in children, and body void is weak, edema, beriberi.

Rhizoma Sparganii

This product is the dry tuber of Sparganiaceae plant rhizoma scirpi Sparganium stoloni ferum Buch.-Ham..Acrid in the mouth, hardship, property is flat.Return liver, spleen channel.The circulation of qi promoting of function removing blood stasis, removing food stagnancy pain relieving.For abdominal mass abdominal mass mass in the abdomen, dysmenorrhea, blood stasis amenorrhea, obstruction of qi in the chest and cardialgia, food stagnation distending pain.

Rhizoma Drynariae

This product is the dry rhizome of Plants of Polypodiaceae Mongolian oak Herba pteridii latiusculi Drynaria fortunei (Kunze) J. Sm..Bitter in the mouth, warm in nature.Return liver.Kidney channel.The function pain relieving of curing the wound, the kidney invigorating bone strengthening. external pathogenic wind expelling speckle dispelling.Be used for falling winking and frustrate, injured bone, lumbago due to renal deficiency, muscles and bones flaccidity is soft, Hiccough and deaf, odontoseisis; External treatment alopecia areata, vitiligo.

Sanguis Draxonis

This product is that the resin that oozes out of babassu Sanguis Draxonis Daemonorops draco Bl. fruit is through being processed into.Sweet in the mouth, salty, property is flat.GUIXIN, Liver Channel.The function analgesic therapy of invigorating blood circulation, removing stasis to stop bleeding, promoting tissue regeneration and ulcer healing.For traumatic injury, trusted subordinate's stasis of blood pain, traumatic hemorrhage, skin infection is not held back.

Rhizoma Chuanxiong

This product is the dry rhizome of samphire Rhizoma Chuanxiong Ligusticum chuanxiong Hort..Acrid in the mouth, warm in nature.Return liver, gallbladder, pericardium channel.Function blood-activating and qi-promoting, wind-expelling pain-stopping.For obstruction of qi in the chest and cardialgia, the twinge of the breast side of body, tumbling and swelling, menoxenia, amenorrhea dysmenorrhea, abdominal mass abdominal mass stomachache, headache, rheumatic arthralgia.

The Radix Angelicae Dahuricae

This product is plant Radix Angelicae Dahuricae Angelica dahurica (Fisch.ex Hoffm.) the Benth. et Hook.f. of umbellate form section or Radix angelicae dahuricae Angelica dahurica(Fisch.ex Hoffm.) Benth.et Hook.f. var.formosana(Boiss.) dry root of Shan et Yuan.Acrid in the mouth, warm in nature.Return stomach, large intestine, lung meridian.The function cold expelling that induces sweat, wind-expelling pain-stopping, a surname's clearing the nasal passage, dampness leukorrhagia stopping, detumescence and apocenosis.For headache due to common cold, supraorbital bone pain, nasal obstruction watery nasal discharge, allergic rhinitis, nasal sinusitis, toothache, leukorrhagia, skin infection swells and ache.

Fructus Chaenomelis

This product is the dry almost ripe fruit of rosaceous plant chaenomeles lagenaria Chaenomeles speciosa (Sweet) Nakai.Sour in the mouth, warm in nature.Return liver, spleen channel.Function relaxing muscles and tendons and activating QI and blood in the collateral. stomach function regulating removing dampness.For arthralgia chiefly caused by damp pathogen contracture. the heavy pain of waist knee joint acid. heat-damp in summer is vomited and diarrhoea, convulsion spasm and pain, beriberi edema.

Borneolum Syntheticum: this product is borneolum syntheticum.Meet the requirements under " Chinese Pharmacopoeia " 2010 version 136 pages of Borneolum Syntheticums of a text (borneolum syntheticum).

The Chinese medicine for the treatment of cervical spondylosis of the present invention, prolapse of lumbar intervertebral disc, scapulohumeral periarthritis, for fracture muscle and tendon injury, QI-blood circulation is not smooth, and blood stasis is most, the contracture of muscle flesh, the diseases such as anemofrigid-damp arthralgia joint joint stuffiness, with bone strengthening exhibition muscle, clear sharp joint, fresh breeze dredging collateral is key point.

Among raw material composition of the present invention, Herba clematidis intricatae expelling wind and removing dampness, channels sootheing and network vessel quickening, promoting blood circulation and stopping pain, Cortex erythrinae wind-damp dispelling, removing obstruction in the collateral to relieve pain, Herba Lycopodii relaxing muscles and tendons and activating QI and blood in the collateral, the active relaxing muscles and tendons of three medicines, eliminating impediment, promoting blood circulation, dredging meridian and relieving pain;

Cortex Acanthopancis, Radix Clematidis dispelling wind and removing obstruction in the collateral strengthening bone and muscle, " Mingyi Bielu " " invigorating middle warmer benefit essence, hard muscles and bones ", Rhizoma Drynariae invigorating the liver and kidney, bone and muscle strengthening, the meridian dredging;

RHZOMA SPARGANII, Sanguis Draxonis are the stagnant pain card of traumatology and stasis of blood key medicine, " Haiyao Bencao, Oversea Materia Medica " " leading wound is fallen damage, all pain, and tonify deficiency and vim and vigour are stirred thorn, interior blood trouble is poly-", two medicines are played removing blood stasis altogether, effect of circulation of qi promoting analgesic therapy;

Full side's compatibility, bone strengthening exhibition muscle, clear sharp joint, fresh breeze dredging collateral, makes that bone is strong, muscle relaxes, joint is sharp, through ruton.

Chinese medicine of the present invention has fully demonstrated the Therapeutic Principle of tcm treatment according to syndrome differentiation, and prescription is scientific and reasonable, and raw material is easy to be easy to get, economic and practical, the property of medicine is steady, and effect comprehensively, all has good curative effect for diseases such as cervical spondylosis, prolapse of lumbar intervertebral disc, osteoarthritis.After having added Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Fructus Chaenomelis, Borneolum Syntheticum, better to the therapeutic effect of above disease.Chinese medicine of the present invention has outstanding substantive distinguishing features and significant progressive with respect to prior art.

As the clinical test results of embodiment 11～14 shows, Chinese medicine external of the present invention can effectively be treated cervical spondylosis, prolapse of lumbar intervertebral disc, osteoarthritis etc., in the clinical process treating, has no toxic and side effects, safe and reliable.

Detailed description of the invention

Embodiment 1

Herba clematidis intricatae 100g Herba Lycopodii 100g Radix Clematidis 100g

Cortex erythrinae 100g Cortex Acanthopancis 100g Rhizoma Drynariae 100g

Rhizoma Sparganii 100g Sanguis Draxonis 100g

Get above-mentioned medical material, adding 800g volume by volume concentration is 45% alcohol dipping 18 hours, then the ethanol that is 45% with volume by volume concentration carries out percolation with the speed that accounts for raw material total weight parts 0.3% per minute, collect the percolate of 4800g, reclaim ethanol, be evaporated to 800g, filter, obtain active component.

Embodiment 2

Herba clematidis intricatae 400g Herba Lycopodii 100g Radix Clematidis 400g

Cortex erythrinae 400g Cortex Acanthopancis 100g Rhizoma Drynariae 100g

Rhizoma Sparganii 400g Sanguis Draxonis 10g.

Get above-mentioned medical material, adding 3900g volume by volume concentration is 56% alcohol dipping 36 hours, and the ethanol that is then 56% with volume by volume concentration carries out percolation with the speed that accounts for raw material total weight parts 0.5% per minute, collects the percolate of 15000g, filter, obtain tincture of the present invention.

Embodiment 3

Herba clematidis intricatae 300g Herba Lycopodii 300g Radix Clematidis 200g

Cortex erythrinae 200g Cortex Acanthopancis 300g Rhizoma Drynariae 300g

Rhizoma Sparganii 100g Sanguis Draxonis 30g.

Get above-mentioned medical material, adding 2600g volume by volume concentration is 48% alcohol dipping 40 hours, then the ethanol that is 50% with volume by volume concentration carries out percolation with the speed that accounts for raw material total weight parts 0.4% per minute, collect the percolate of 20000g, reclaim ethanol, be evaporated to 3000g, filter, obtain active component.

Active component is concentrated in right amount, adds the adjuvants such as appropriate adhesive, wetting agent, filler, stir, coat on back lining materials, obtain gel rubber plaster unguentum of the present invention.

Embodiment 4

Herba clematidis intricatae 400g Herba Lycopodii 400g Radix Clematidis 400g

Cortex erythrinae 200g Cortex Acanthopancis 200g Rhizoma Drynariae 200g

Rhizoma Sparganii 200g Sanguis Draxonis 60g.

Get above-mentioned medical material, adding 2500g volume by volume concentration is 52% alcohol dipping 44 hours, then the ethanol that is 45% with volume by volume concentration carries out percolation with the speed that accounts for raw material total weight parts 0.5% per minute, collect the percolate of 18000g, reclaim ethanol, be evaporated to 2300g, filter, obtain active component.

Active component is mixed homogeneously with appropriate antioxidant, propellant, obtain aerosol of the present invention.

Embodiment 5

Herba clematidis intricatae 100g Herba Lycopodii 200g Radix Clematidis 100g

Cortex erythrinae 300g Cortex Acanthopancis 300g Rhizoma Drynariae 300g

Rhizoma Sparganii 200g Sanguis Draxonis 80g.

Get above-mentioned medical material, adding 3000g volume by volume concentration is 52% alcohol dipping 22 hours, then the ethanol that is 50% with volume by volume concentration carries out percolation with the speed that accounts for raw material total weight parts 0.2% per minute, collect the percolate of 12000g, reclaim ethanol, be evaporated to 3000g, filter, obtain active component.

Active component is concentrated in right amount, coordinates with appropriate water-soluble base, stir, obtain ointment of the present invention.

Embodiment 6

Herba clematidis intricatae 100g Herba Lycopodii 100g Radix Clematidis 100g

Cortex erythrinae 100g Cortex Acanthopancis 100g Rhizoma Drynariae 100g

Rhizoma Sparganii 100g Sanguis Draxonis 100g Rhizoma Chuanxiong 100g

Radix Angelicae Dahuricae 100g Fructus Chaenomelis 100g Borneolum Syntheticum 60g

Get 11 taste medical materials except Borneolum Syntheticum, the alcohol dipping that the volume by volume concentration that adds 1100g is 40% 12 hours, then the ethanol that is 40% with volume by volume concentration carries out percolation with the speed that accounts for raw material total weight parts 0.2% per minute, collect the percolate of 5500g, reclaim ethanol, be evaporated to 1100g, filter, obtain medicinal liquid A;

Medicinal liquid A and Borneolum Syntheticum are active component.

Embodiment 7

Herba clematidis intricatae 400 Herba Lycopodii 400 Radix Clematidis 100

Cortex erythrinae 100 Cortex Acanthopancis 400 Rhizoma Drynariae 100

Rhizoma Sparganii 100 Sanguis Draxonis 100 Rhizoma Chuanxiongs 400

The Radix Angelicae Dahuricae 100 Fructus Chaenomelis 400 Borneolum Syntheticums 40

Get 11 taste medical materials except Borneolum Syntheticum, the alcohol dipping that the volume by volume concentration that adds 5200g is 60% 48 hours, then the ethanol that is 60% with volume by volume concentration carries out percolation with the speed that accounts for raw material total weight parts 0.6% per minute, collect the percolate of 26000g, add Borneolum Syntheticum, stir, filter, obtain tincture of the present invention.

Embodiment 8

Herba clematidis intricatae 200g Herba Lycopodii 100g Radix Clematidis 200g

Cortex erythrinae 300g Cortex Acanthopancis 300g Rhizoma Drynariae 300g

Rhizoma Sparganii 300g Sanguis Draxonis 70g Rhizoma Chuanxiong 200g

Radix Angelicae Dahuricae 300g Fructus Chaenomelis 100g Borneolum Syntheticum 30g

Get 11 taste medical materials except Borneolum Syntheticum, the alcohol dipping that the volume by volume concentration that adds 3400g is 60% 42 hours, then the ethanol that is 56% with volume by volume concentration carries out percolation with the speed that accounts for raw material total weight parts 0.3% per minute, collect the percolate of 22000g, reclaim ethanol, be evaporated to 3000g, filter, obtain medicinal liquid A;

By a small amount of dissolve with ethanol of Borneolum Syntheticum, mix homogeneously with medicinal liquid A, appropriate antioxidant, propellant, obtain aerosol of the present invention.

Embodiment 9

Herba clematidis intricatae 400g Herba Lycopodii 400g Radix Clematidis 400g

Cortex erythrinae 200g Cortex Acanthopancis 200g Rhizoma Drynariae 200g

Rhizoma Sparganii 400g Sanguis Draxonis 10g Rhizoma Chuanxiong 200g

Radix Angelicae Dahuricae 200g Fructus Chaenomelis 200g Borneolum Syntheticum 10g

Get 11 taste medical materials except Borneolum Syntheticum, the alcohol dipping that the volume by volume concentration that adds 4000g is 52% 20 hours, then the ethanol that is 52% with volume by volume concentration carries out percolation with the speed that accounts for raw material total weight parts 0.4% per minute, collect the percolate of 15000g, reclaim ethanol, be evaporated to 3200g, filter, obtain medicinal liquid A;

By a small amount of dissolve with ethanol of Borneolum Syntheticum, obtain solution B;

Medicinal liquid A is concentrated in right amount, mixes with solution B, coordinate with appropriate water-soluble base, stir, obtain ointment of the present invention.

Embodiment 10

Herba clematidis intricatae 200g Herba Lycopodii 200g Radix Clematidis 200g

Cortex erythrinae 200g Cortex Acanthopancis 200g Rhizoma Drynariae 200g

Rhizoma Sparganii 200g Sanguis Draxonis 50g Rhizoma Chuanxiong 150g

Radix Angelicae Dahuricae 150g Fructus Chaenomelis 120g Borneolum Syntheticum 50g

Get 11 taste medical materials except Borneolum Syntheticum, the alcohol dipping that the volume by volume concentration that adds 2880g is 54% 24 hours, then the ethanol that is 54% with volume by volume concentration carries out percolation with the speed that accounts for raw material total weight parts 0.3% per minute, collect the percolate of 11520g, reclaim ethanol, be evaporated to 2880g, filter, obtain medicinal liquid A;

By a small amount of dissolve with ethanol of Borneolum Syntheticum, obtain solution B;

Medicinal liquid A is concentrated in right amount, mixes with solution B, add the adjuvants such as appropriate adhesive, wetting agent, filler, stir, coat on back lining materials, obtain gel rubber plaster unguentum of the present invention.

Embodiment 11

The clinical trial situation for the treatment of by Chinese herbs cervical spondylosis of the present invention:

1, case selection: Drug therapy Patients with Cervical Spondylopathy 24 examples of the clinical use embodiment 3 of Chinese medicine of the present invention, Drug therapy Patients with Cervical Spondylopathy 38 examples of embodiment 10, age 27-70 year, course of disease January-15 year; The diagnosis that patient clinical symptom, sign and imaging examination all meet cervical spondylosis of controlling.

2, diagnostic criteria

(1) medical diagnosis on disease

With reference to Chinese Association of Rehabilitation Medicine cervical spondylosis Professional Committee " cervical spondylosis diagnosis and treatment and rehabilitation guide " in 2009.

There is symptom (numb, pain) and sign that root distributes.

Intervertebral foramina squeeze test is or/and the brachial plexus nerve distraction test positive.

Iconography finding is consistent substantially with clinical manifestation.

(2) Syndrome Diagnostic

Wind chill blockage card: neck, shoulder, upper limb string pain numbness, taking pain as main, head has sense of heaviness, and Wry Neck is movable unfavorable, aversion to cold anemophobia.Light red tongue, white and thin fur, stringy and tense pulse.

Syndrome of blood stasis and stagnant qi: neck and shoulder part, upper limb twinge, sore spot is fixed, with numb limbs and tense tendons.Dark tongue quality, stringy pulse.

Syndrome of phlegm-dampness blocking collaterals: have a dizzy spell, heaviness of the head as if it were tightly bandaged, numb limbs and tense tendons, indigestion and loss of appetite.Red tongue, thick and greasy fur, stringy and rolling pulse.

Deficiency of the liver and kindey card: dizziness and headache, Hiccough and deaf, insomnia and dreamful sleep, numb limbs and tense tendons, flushing conjunctival congestion.The few tongue of red tongue, stringy pulse.

Deficiency of qi and blood card: have a dizzy spell, pale complexion, shortness of breath and palpitation, numb limbs and tense tendons, fatigue and weakness.Light red tongue tongue is few, thready and weak pulse.

3, curative effect determinate standard:

Clinic control: after treatment, symptom and sign disappears, and cervical vertebra moving is normal, after treatment, symptom integral 0-1 divides, therapeutic index >90%.

Effective: after treatment, symptom and sign disappears substantially, and cervical vertebra moving normal, can participate in normal activity and work, therapeutic index >70% ,≤90%.

Effective: after treatment, symptom and sign makes moderate progress, cervical vertebra moving normal, participates in normal activity and ability to work and improves, therapeutic index >30% ,≤70%.

Invalid: after treatment, before symptom and sign and treatment, to be not improved therapeutic index≤30%.

* integration × 100% before therapeutic index=(the rear integration of integration-treatment before treatment)/treatment

4, drug use method and points for attention

Formula one: Herba clematidis intricatae, Herba Lycopodii, Radix Clematidis, Cortex erythrinae, Cortex Acanthopancis, Rhizoma Drynariae, Rhizoma Sparganii, Sanguis Draxonis, the medicine of the embodiment of the present invention 3, each medicine that is equivalent to crude drug amount 140g that uses.

Formula two: Herba clematidis intricatae, Herba Lycopodii, Radix Clematidis, Cortex erythrinae, Cortex Acanthopancis, Rhizoma Drynariae, Rhizoma Sparganii, Sanguis Draxonis, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Fructus Chaenomelis, Borneolum Syntheticum, the medicine of embodiment 10, each medicine that is equivalent to crude drug amount 190g that uses.

Be affixed on affected part external, once-a-day, each 6-8 hour; Skin allergy, local skin ulceration or blood disease, anemia of pregnant woman are cautious use of.

Using continuously 7 days was 1 course for the treatment of, treated two to three courses for the treatment of, can significantly improve the symptoms such as cervical pain, dizziness, upper limb numbness.

5, therapeutic outcome table

Title	Clinical effective	Clinical effective	Invalid	Total effective rate
					Embodiment 3	8 examples (33.3%)	14 examples (58.3%)	2 examples (8.3)	22 examples (91.6%)
Embodiment 10	17 examples (44.7%)	19 examples (50%)	2 examples (5.3%)	36 examples (94.7%)

Embodiment 12

The clinical trial situation for the treatment of by Chinese herbs prolapse of lumbar intervertebral disc of the present invention:

1, case selection: Drug therapy patients with lumbar disc herniation 21 examples of the clinical use embodiment 2 of Chinese medicine of the present invention, are used Drug therapy 46 examples of embodiment 7, age 35-68 year, course of disease first quarter moon-20 year; The diagnosis that patient clinical symptom, sign and imaging examination all meet prolapse of lumbar intervertebral disc of controlling.

2, diagnostic criteria

(1) medical diagnosis on disease

With reference to People's Republic of China's Chinese medicine industry standard (traditional Chinese medical science disease Standardization of diagnosis and curative effect) of State Administration of Traditional Chinese Medicine's issue in 1994.

There are waist wound, chronic strain or cold-damp history more.Most of patient has chronic back pain history at premorbid more.

Normal sending out in person between twenty and fifty.

Lumbago is to buttocks and lower limb radiation, and when abdominal pressure increases (as cough, sneeze), pain increases the weight of.

Scoliosis, lumbar vertebra physiologic radian disappears, and diseased region vertebra is other tenderness, and to lower limb radiation, waist limitation of activity.

The lower limb innervation district that gets involved feels irritatedly or blunt, and amyotrophy can appear in course of disease elder.Straight lower limb is raised or to strengthen test positive, knee joint, with treading on hyporeflexia or disappearance, and the big toe back of the body power of stretching can weaken.

X-ray is taken the photograph sheet inspection: scoliosis, waist physiology lordosis shoal, and pathological interspinal gap may narrow, and respective edges can have osteophytosis.CT or MRI check position and the degree that can show intervertebral disk hernia.

(2) Syndrome Diagnostic

Syndrome of blood stasis and stagnant qi: waist has trauma history in the recent period, and lumbago and skelalgia is violent, localized pain, twinge, waist is stiff, and pitching activity is difficult, sore spot tenderness, body of the tongue is dark violet, or has ecchymosis, thin white fur of tongue or BOHUANG, deep and hesitant pulse or stringy pulse.

Cold-dampness numbness card: waist shank cold type of pain is weighing, and changes one's position unfavorable, and localized pain, does not also subtract or increase the weight of on the contrary though repose, a day light night is heavy, and pain increase in intensity under coldness obtains and hotly subtracts, and body of the tongue is fat light, and tongue is greasy in vain, and stringy and tense pulse, string are slow or heavy tight.

Damp-heat arthralgia resistance card: lumbago and skelalgia, sore spot is with hotness, or sees podomere redness, feeling thirst but no desire to drink, yellow and greasy fur, soft and rapid pulse or sliding number.

Caused by liver and kidney deficiency card: with the passing of time lumbago and skelalgia touching, outbreak repeatedly, weak, do not endure hardships, labor increases the weight of, sleeping alleviate; Comprise the hepatic and renal YIN deficiency and deficiency of yang of liver and kidney card.Yin deficiency syndrome disease is seen: vexed insomnia, bitter taste in the mouth and dry throat, red tongue with a little fluid, stringy and thready pulse and counting.Yang deficiency syndrome disease is seen: extremity are not warm, and cold physique fear is cold, the contracture of muscle arteries and veins, the disease such as pale tongue is fat, deep,thready and forceless pulse.

3, curative effect determinate standard:

Carry out therapeutic evaluation with reference to JOA lumbago and skelalgia marking system, treatment improvement rate=[(scoring before scoring-treatment after treatment) ÷ (scoring before full marks 29-treatment)] × 100%.

Clinic control: improvement rate >=75%; Lumbago and skelalgia and relevant symptoms disappear, and Negative straight-leg raising test recovers normally to work;

Effective: lumbago and skelalgia and relevant symptoms disappear substantially, Negative straight-leg raising test, basic recovery normally worked; Improvement rate >=50 and <75%;

Effective: lumbago and skelalgia and relevant symptoms alleviate, straight-leg raising test probable positive, part is resumed work, but has recurrence after drug withdrawal; Improvement rate >=25 and <50%;

Invalid: lumbago and skelalgia and relevant symptoms sign be without improvement, the straight-leg raising test positive, or increase the weight of improvement rate <25%.

4, drug use method and points for attention

Formula one: Herba clematidis intricatae, Herba Lycopodii, Radix Clematidis, Cortex erythrinae, Cortex Acanthopancis, Rhizoma Drynariae, Rhizoma Sparganii, Sanguis Draxonis, the medicine of the embodiment of the present invention 2, each medicine that is equivalent to crude drug amount 80g that uses.

Formula two: Herba clematidis intricatae, Herba Lycopodii, Radix Clematidis, Cortex erythrinae, Cortex Acanthopancis, Rhizoma Drynariae, Rhizoma Sparganii, Sanguis Draxonis, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Fructus Chaenomelis, Borneolum Syntheticum, the medicine of embodiment 7, each medicine that is equivalent to crude drug amount 100g that uses.

With towel soak in affected part external, three times on the one, each 1-2 hour; Skin allergy, local skin ulceration or blood disease, anemia of pregnant woman are cautious use of.

Using continuously 7 days was 1 course for the treatment of, treated one to three course for the treatment of, obtained good clinical effectiveness.

5, therapeutic outcome table

Title	Clinical effective	Clinical effective	Invalid	Total effective rate
					Embodiment 2	6 examples (28.5%)	11 examples (52.4%)	4 examples (19.1)	17 examples (80.9%)
Embodiment 7	20 examples (43.4%)	21 examples (45.7%)	5 examples (10.9%)	41 examples (89.1%)

Embodiment 13

The clinical trial situation for the treatment of by Chinese herbs knee joint numbness disease of the present invention:

1, case selection: Drug therapy knee joint numbness patient 18 examples of the clinical use embodiment 3 of Chinese medicine of the present invention, knee joint numbness disease is also referred to as knee joint osseous arthritis, uses Drug therapy 47 examples of embodiment 10, age 40-78 year, course of disease half a year-20 year; The diagnostic criteria that patient clinical symptom, sign and imaging examination all meet knee joint numbness disease of controlling.

2, diagnostic criteria

(1) medical diagnosis on disease

With reference to orthopaedics and tranmstology branch of Chinese Medical Association " osteoarthrosis diagnosis and treatment guide " (version in 2007).

Clinical manifestation: kneed pain and tenderness, ankylosis, arthroncus, bony crepitus (sense), joint are unable, moving obstacle.

Imaging examination

X-ray checks: the x-ray feature of osteoarthritis shows as asymmetry joint space and narrows, Subchondral bone sclerosis and cystis degeneration, and edge, joint hyperosteogeny and hyperosteogeny form; Articular mobile corpus, joint deformity and subluxation.

Lab testing: the indications such as routine blood test, protein electrophoresis, immune complex and SC are generally in normal range.Slightly raise with the visible c reactive protein of synovitis person (CRP) and erythrocyte sedimentation rate (ESR), rheumatoid factor and negative antinuclear antibodies.

(2) Syndrome Diagnostic

Arthralgia due to wind-cold-dampness disease: the miserable pain of limbs joint, sore spot are fixed, just like lancinating or having obvious weighing sense or affected part performance swelling sense, joint motion is owed flexibly, and anemophobia is cold, get Re Zeshu.Pale tongue, tongue is greasy in vain, tense pulse or moisten.

Rheumatic fever arthromyodynia: onset is more anxious, pathological changes redness and swelling of joints, scorching hot, pain, even pain can not be touched, and obtains cold relaxing for feature; Can generate heat with whole body, or skin erythema, scleroma.Red tongue, yellow fur, slippery and rapid pulse.

Blood stasis impatency card: limbs joint twinge, sore spot is fixed, and there is stiff sense part, or apathetic, purplish tongue, Tai Bai and dry and astringent.

Caused by liver and kidney deficiency card: knee joint has a dull ache, and soreness of the waist and knees is unable, aching and tired pain, meets labor more very, red tongue, few tongue, deep,thready and forceless pulse.

3, curative effect determinate standard:

Clinical cure: gonalgia, swelling disappear completely, walking and stair activity are without sense of discomfort.

Effective: tranquillization is without gonalgia, and without swelling, pain while occasionally having activity, without pain, does not affect work and life when walking.

Effective: while sending out when gonalgia, only, when walking, still have mild pain, upper slightly sense inconvenience downstairs, joint motion is slightly limited.

Invalid: gonalgia, swelling and when movable pain be not improved.

Adopt international knee osteoarthritis WOMAC scale (v3. 1) to carry out joint index scoring criterion.

4, drug use method and points for attention

Formula one: Herba clematidis intricatae, Herba Lycopodii, Radix Clematidis, Cortex erythrinae, Cortex Acanthopancis, Rhizoma Drynariae, Rhizoma Sparganii, Sanguis Draxonis, the medicine of the embodiment of the present invention 5, each medicine that is equivalent to crude drug amount 100g that uses.

Formula two: Herba clematidis intricatae, Herba Lycopodii, Radix Clematidis, Cortex erythrinae, Cortex Acanthopancis, Rhizoma Drynariae, Rhizoma Sparganii, Sanguis Draxonis, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Fructus Chaenomelis, Borneolum Syntheticum, the medicine of embodiment 9, each medicine that is equivalent to crude drug amount 130g that uses.

Be affixed on affected part external, once-a-day, each 3-4 hour; Skin allergy, local skin ulceration or blood disease, anemia of pregnant woman are cautious use of.

Using continuously 7 days was 1 course for the treatment of, treated one to three course for the treatment of, obtained good clinical effectiveness.

5, therapeutic outcome table

Title	Clinical effective	Clinical effective	Invalid	Total effective rate
					Embodiment 5	9 examples (50%)	7 examples (38.9%)	2 examples (11.1)	16 examples (88.9%)
Embodiment 9	32 examples (68%)	11 examples (23%)	4 examples (9%)	43 examples (91%)

Embodiment 14

The clinical trial situation for the treatment of by Chinese herbs scapulohumeral periarthritis of the present invention:

1, case selection: Drug therapy Patients with Cervical Spondylopathy 21 examples of the clinical use embodiment 3 of Chinese medicine of the present invention, Drug therapy Patients with Cervical Spondylopathy 35 examples of embodiment 10, age 45-70 year, course of disease January-1.5 year; The diagnosis that patient clinical symptom, sign and imaging examination all meet scapulohumeral periarthritis of controlling.

2, diagnostic criteria

(1), tcm diagnosis: with reference to " People's Republic of China's Chinese medicine industry standard " disease of tcm Standardization of diagnosis and curative effect " (ZY/T001.9-94).

1., wind and cold damp syndrome: shoulder is altered pain, meets wind and cold pain and increases, and obtains warm pain slow, anemophobia aversion to cold; Or shoulder has sense of heaviness.Light red tongue, thin white fur of tongue or greasy, stringy and rolling pulse or stringy and tense pulse.

2., the stagnant card of the stasis of blood: shoulder swells and ache, pain with tenderness, with night for very.Tongue is dark or have an ecchymosis, the white or BOHUANG of tongue fur, stringy pulse or carefully puckery.

3., QI and blood deficiency syndrome: shoulder is ached, tired after pain increase the weight of, companion has a dizzy spell, the lazy speech of breathing hard, palpitation and insomnia, limbs fatigue, light red tongue, few tongue or tongue fur are white, thready and weak pulse or heavy.

(2), Western medicine diagnose standard: with reference to " newly organized practical orthopaedics and tranmstology " second edition (Tao Tianzun chief editor, military medicine Science Press, 2008).

1., symptom and sign: this disease is chronic disease, and most without trauma history, minority only has microtrauma.Cardinal symptom is shoulder pain and the shoulder joint moving obstacle increasing the weight of gradually.

A, pain can be radiated to elbow, hands and omoplate district outside being positioned at before shoulder sometimes, but numbness obstacle.Night, pain increased the weight of, and impact sleep, dare not Ipsilateral clinostatism.Constant pain can cause muscle spasm and amyotrophy.Take on forward and backward side, under acromion, there is tenderness at triangular muscle stop place, and the most obvious with brachial biceps portion tenderness, when abduction of the upper limb, outward turning, after the pain increased while stretching.

B, early stage shoulder joint activity are only rotary with slight effect internally, outward, should fix scapula, both sides comparison when inspection.Late period, upper arm was in inward turning position, and all directions activity is all limited, but limited obviously with abduction, interior outward turning, the activity of fore-and-aft direction generally exists., sometimes because upper limb blood circulatory disorder occurs in concurrent vasospasm, there is forearm and hand swelling in the now obvious atrophy of shoulder muscle, sends out cool and the symptom such as finger movement pain.

2., x-ray inspection: can Non Apparent Abnormality.Shoulder joint radiography has capsula articularis humeri contraction, joint capsule bottom gauffer to disappear, the scapulohumeral periarthritis later stage can occur that serious osteoporosis changes, particularly proximal humerus, the performance that severe one has similar " molten bone " destroys, but have a medical check-up and be easy to differentiate and come with bone tumor by medical history and part.

3, curative effect determinate standard:

Entirety efficacy evaluation is the criterion of therapeutical effect about " scapulohumeral periarthritis " with reference to " new Chinese medicine guideline of clinical investigations " (Ministry of Public Health is developed and published, 1997 the 3rd volume):

Cure (clinical recovery): shoulder pain disappears, it is normal that shoulder joint range of activity is recovered.

Effective: shoulder pain is alleviated obviously, and shoulder joint range of activity is improved obviously.

Effective: shoulder pain is alleviated substantially, shoulder joint range of activity part is improved.

Invalid: symptom is without change.

4, drug use method and points for attention

Formula one: Herba clematidis intricatae, Herba Lycopodii, Radix Clematidis, Cortex erythrinae, Cortex Acanthopancis, Rhizoma Drynariae, Rhizoma Sparganii, Sanguis Draxonis, the medicine of the embodiment of the present invention 3, each medicine that is equivalent to crude drug amount 120g that uses.

Formula two: Herba clematidis intricatae, Herba Lycopodii, Radix Clematidis, Cortex erythrinae, Cortex Acanthopancis, Rhizoma Drynariae, Rhizoma Sparganii, Sanguis Draxonis, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Fructus Chaenomelis, Borneolum Syntheticum, the medicine of embodiment 10, each medicine that is equivalent to crude drug amount 180g that uses.

Be affixed on affected part external, once-a-day, each 6-8 hour; Skin allergy, local skin ulceration or blood disease, anemia of pregnant woman are cautious use of.

Using continuously 7 days was 1 course for the treatment of, treated two to three courses for the treatment of, can significantly improve the symptom such as shoulder pain, shoulder joint activity.

5, therapeutic outcome table

Title	Clinical effective	Clinical effective	Invalid	Total effective rate
					Embodiment 3	8 examples (38.1%)	11 examples (52.4%)	2 examples (9.5)	22 examples (90.4%)
Embodiment 10	16 examples (45.7%)	17 examples (48.6%)	2 examples (5.7%)	36 examples (94.3%)

Embodiment 15

1, Huang × ×, female, 42 years old, on February 20th, 2012 was medical.Because " neck-shoulder pain companion right upper extremity is altered pain numb one week " is admitted to hospital.Patient's private prosecution sense neck and shoulder part pain miserable discomfort that began before 1 week, movable unfavorable, it is numb that companion's right upper extremity is altered pain, through having a rest, remission is not obvious after massage voluntarily; The disease opinion of being admitted to hospital: the miserable discomfort of neck and shoulder part pain, movable unfavorable, companion's right upper extremity alters that pain is numb, when movable, pain increases the weight of, cold extremities, fear of cold, spirit is general, receive can, two just can, sleep poor, without having a dizzy spell, Hiccough and deaf, shortness of breath and palpitation.C spine open mouth, positive side diclinic position, function bit slice show: cervical vertebra degenerative change, hyperosteogeny of cervical vertebra.AD: cervical spondylosis (spondylotic radiculopathy)--wind chill blockage card.Give medicine of the present invention, once a day, after the course for the treatment of, patient's neck and shoulder part pain obviously alleviates in cervical region external application, and right upper extremity fiber crops pain is obviously alleviated, cervical region improving action; Continue to use one week, totally 2 courses for the treatment of, patient's neck and shoulder part pain is not obvious, and right upper extremity is without significant discomfort, and cervical region is movable normal, without cold extremities, fear of cold, does not recur so far again.

2, old × ×, man, 46 years old, on February 9th, 2012 was medical.Because " neck and shoulder part pain, movable unfavorable companion's left upper extremity fiber crops pain one week " is admitted to hospital.The disease opinion of being admitted to hospital: neck and shoulder part pain, cervical vertebra moving is unfavorable, left upper extremity fiber crops pain, moving pain increases the weight of, and has a dizzy spell, head is tired weighs, without Hiccough and deaf, shortness of breath and palpitation; Without aversion to cold anemophobia, spirit can, indigestion and loss of appetite, large loose stool, sleeping night can.C spine open mouth, positive side diclinic position, function bit slice show: cervical vertebra degenerative change, hyperosteogeny of cervical vertebra.AD: cervical spondylosis (spondylotic radiculopathy)--syndrome of phlegm-dampness blocking collaterals.After being admitted to hospital, give medicine cervical region of the present invention external application once a day, use after the course for the treatment of, patient's neck and shoulder part and left upper extremity pain before alleviate, and cervical vertebra moving is front improvement, and dizzy symptom alleviates, and a tired reinfection is alleviated; Continue external application for curing, cure and leave hospital after totally 2 courses for the treatment of, patient's neck and shoulder part pain is not obvious, and left upper extremity is without significant discomfort, and cervical region is movable normal, and without having a dizzy spell, head is without tired reinfection; Follow up a case by regular visits to so far, not recurrence.

3, Ni × ×, female, 42 years old, medical on March 26th, 2012.There is flank pain without obvious inducement in patient's private prosecution, limitation of activity, still can stand at the beginning of 2011, and stand activity and meet cold postemphasis of fatigue, alleviates after lying up.The back lumbar part pain of suffering from cold of drenching with rain before 1 week increases the weight of, and to right lower extremity radiating pain, when cough and abdominal part are exerted oneself, the pain increased, can not stand up.Disease is seen: waist shank cold type of pain is weighing, and changes one's position unfavorable, and localized pain, does not also subtract or increase the weight of on the contrary though repose, and a day light night is heavy, and pain increase in intensity under coldness obtains and hotly subtracts.Lumbar vertebra MRI shows: lumbar retrogression, L5/S1 intervertebral disk hernia.DR(l spine ap & lat+mistake extends through bends position+left and right loxosis) show: lumbar vertebra front and rear edge degree of taking a favourable turn hyperostosis osteosclerosis, lumbar vertebra osteoarthritis.Diagnosis: L5/S1 intervertebral disc prolapse (acute stage)--cold-dampness numbness card.Give the local external application of medicine of the present invention, once a day, use continuously after 1 week, patient tells the miserable discomfort of flank pain and alleviates, and functional activity improves; Continue to use Drug therapy of the present invention, totally 2 courses for the treatment of, patient's lumbago is removed to the greatest extent, and right lower extremity is without sense of discomfort, and activity obviously improves, and follows up a case by regular visits to so far not recurrence.

4, symbol × ×, man, 48 years old, goes to a doctor because of " waist is interrupted pain and within more than 2 years, increases the weight of to accompany left lower extremity radiating pain 1 week " on May 25th, 2012.Disease is seen: patient god is clear, spirit can, without discomforts such as fever with aversion to cold, dizziness headache, nausea and vomiting, tell waist shank cold type of pain weighing, change one's position unfavorable, localized pain, does not also subtract or increases the weight of on the contrary though repose, and day light night is heavy, pain increase in intensity under coldness, must hotly subtract, body of the tongue is fat light, and tongue is greasy in vain, stringy and tense pulse.Lumbar vertebra CT shows: L4/5 prolapse of lumbar intervertebral disc, and left side root compression is obvious, degenerative lumbar; MRI shows: L4/5 prolapse of lumbar intervertebral disc, and left side root compression is obvious, lumbar degenerative changes; DR shows: L4/5 intervertebral disc prolapse; Lumbar vertebra osteoarthritis.Diagnosis: L4/5 intervertebral disc prolapse (acute stage)--cold-dampness numbness card.Give the outstanding sections corresponding position Herbal medicines for external use of the present invention of waist, once a day, treat continuously after 2 courses for the treatment of, patient's waist is without obvious pain, and left lower extremity is without obvious radiating pain, and left lower extremity straight-leg raising test (-), strengthens test (-).Follow up a case by regular visits to so far, more not recurrence.

5, old × ×, man, 67 years old, medical on May 29th, 2012.Because " double knee joint pain, limitation of activity more than 6 years, increase the weight of January " is in hospital.The disease opinion of being admitted to hospital: double knee joint mild swelling, twinge, sore spot is fixed, and there is stiff sense part, limitation of activity.Patient's mind is clear, and spirit is general, stomach receive can, two just adjust, the peace of sleeping night, purplish tongue, Tai Bai and dry and astringent, stringy pulse.Two knee joint x-rays show: double knee joint gap asymmetry narrows, and edge, joint hyperosteogeny is obvious, meets double knee joint degenerative change.AD: two knee joint numbness diseases (mid-term)--blood stasis impatency card.Give the local external application of medicine double knee joint of the present invention, once a day, treat after 2 courses for the treatment of, patient tells double knee joint without obvious pain, and tranquillization is without gonalgia, without swelling.Follow up a case by regular visits to so far, not recurrence.

6, woods × ×, female, 76 years old, goes to a doctor because of " the right gonalgia, limitation of activity more than 1 year, increase the weight of January " on February 14th, 2012.Disease is seen: right knee joint mild swelling, and twinge, sore spot is fixed, and there is stiff sense part, limitation of activity.Patient's mind is clear, and spirit is general, stomach receive can, two just adjust, the peace of sleeping night, purplish tongue, Tai Bai and dry and astringent, stringy pulse.Right knee joint x-ray shows: right knee space asymmetry narrows, and edge, joint hyperosteogeny is obvious, meets knee joint degenerative change, right knee joint osseous arthritis, patella degeneration.Diagnosis: right knee joint numbness disease (mid-term)--blood stasis impatency card.Give the local external application of the right knee joint of medicine of the present invention, once a day, treat after one week, the right gonalgia of patient obviously alleviates before, mobility improvement; Continue to use the local external application of medicine of the present invention, the right knee joint of patient is without obvious pain, without swelling, local without obvious tenderness, the activity of bending and stretching can, when walking without pain.Follow up a case by regular visits to so far, have no recurrence.

7, leaf × ×, female, 52 years old, on November 21st, 2011 was medical.Because " left shoulder pain, left shoulder joint limitation of activity February " is admitted to hospital.Patient's private prosecution began to feel the miserable discomfort of left shoulder pain before February, movable unfavorable, and after having a rest, massaging voluntarily, remission is not obvious; The disease opinion of being admitted to hospital: the miserable discomfort of left shoulder pain, left shoulder joint activity is unfavorable, upper act and the back of the body are stretched limited, anemophobia aversion to cold, spirit is general, receive can, two just can, sleep poor, without having a dizzy spell, Hiccough and deaf, shortness of breath and palpitation.Left shoulder joint X sheet (118524) shows: left shoulder joint osteoarthritis, greater tubercle hyperosteogeny.AD: left scapulohumeral periarthritis--wind and cold damp syndrome.Give medicine cervical region of the present invention external application once a day, after the course for the treatment of, the left shoulder pain of patient obviously alleviates, left shoulder joint improving action; Continue to use one week, totally 2 courses for the treatment of, the left shoulder pain of patient is not obvious, and left shoulder joint activity normal, without cold extremities, fear of cold, does not recur so far again.

8, week × ×, man, 57 years old, on January 5th, 2012 was medical.Because " left shoulder pain, movable unfavorable companion is remaining January " is admitted to hospital.The disease opinion of being admitted to hospital: left shoulder pain, left shoulder joint activity is unfavorable, and moving pain increases the weight of, and head is tired heavy, companion's Hiccough and deaf, shortness of breath and palpitation; Without aversion to cold anemophobia, spirit can, sleep night can, under left acromion, there is obvious tenderness at intertubercular sulcus place.Left shoulder joint X sheet (121654) shows: left shoulder joint osteoarthritis changes, and joint space narrows, and sees bone calcification around.AD: left scapulohumeral periarthritis--QI and blood deficiency syndrome.After being admitted to hospital, give medicine cervical region of the present invention external application once a day, use after the course for the treatment of, the left shoulder pain of patient before alleviates, and joint motion is front improvement, and dizzy symptom alleviates; Continue Herbal medicines for external use treatment of the present invention, cure and leave hospital after totally 2 courses for the treatment of, the left shoulder pain of patient is not obvious, and left shoulder joint activity is normal, without obviously having a dizzy spell; Follow up a case by regular visits to so far, not recurrence.

Claims (15)

1. treat an external application Chinese medicine for cervical spondylosis, prolapse of lumbar intervertebral disc, scapulohumeral periarthritis, it is characterized in that it is to be prepared from by the raw material of following weight portion:

Herba clematidis intricatae 10～40 Herba Lycopodii 10～40 Radix Clematidis 10～40

Cortex erythrinae 10～40 Cortex Acanthopancis 10～40 Rhizoma Drynariae 10～40

Rhizoma Sparganii 10～40 Sanguis Draxonis 1～10.

2. the external application Chinese medicine for the treatment of cervical spondylosis as claimed in claim 1, prolapse of lumbar intervertebral disc, scapulohumeral periarthritis, is characterized in that it is to be prepared from by the raw material of following weight portion:

Herba clematidis intricatae 10～30 Herba Lycopodii 10～30 Radix Clematidis 10～30

Cortex erythrinae 10～30 Cortex Acanthopancis 10～30 Rhizoma Drynariae 10～30

Rhizoma Sparganii 10～30 Sanguis Draxonis 3～8.

3. the external application Chinese medicine for the treatment of cervical spondylosis as claimed in claim 1 or 2, prolapse of lumbar intervertebral disc, scapulohumeral periarthritis, is characterized in that the preparation method of its active component comprises the following steps:

Get 8 described taste medical materials, add and be equivalent to the alcohol dipping 12～48 hours that the volume by volume concentration of 1～2 times of this 8 taste medical material gross weight is 40%～60%, then the ethanol that is 40%～60% with volume by volume concentration carries out percolation with the speed that accounts for raw material total weight parts 0.2%～0.6% per minute, collection is equivalent to the percolate that this 8 taste medical material gross weight 5-10 doubly measures, reclaim ethanol, be evaporated to and be equivalent to 1～2 times of 8 taste medical material gross weights, filter, obtain active component.

4. treat an external application Chinese medicine for cervical spondylosis, prolapse of lumbar intervertebral disc, scapulohumeral periarthritis, it is characterized in that it is to be prepared from by the raw material of following weight portion:

Herba clematidis intricatae 10～40 Herba Lycopodii 10～40 Radix Clematidis 10～40

Cortex erythrinae 10～40 Cortex Acanthopancis 10～40 Rhizoma Drynariae 10～40

Rhizoma Sparganii 10～40 Sanguis Draxonis 1～10 Rhizoma Chuanxiongs 10～40

The Radix Angelicae Dahuricae 10～40 Fructus Chaenomelis 10～40 Borneolum Syntheticums 1～6.

5. the external application Chinese medicine for the treatment of cervical spondylosis as claimed in claim 4, prolapse of lumbar intervertebral disc, scapulohumeral periarthritis, is characterized in that it is to be prepared from by the raw material of following weight portion:

Herba clematidis intricatae 10～30 Herba Lycopodii 10～30 Radix Clematidis 10～30

Cortex erythrinae 10～30 Cortex Acanthopancis 10～30 Rhizoma Drynariae 10～30

Rhizoma Sparganii 10～30 Sanguis Draxonis 3～8 Rhizoma Chuanxiongs 10～30

The Radix Angelicae Dahuricae 10～30 Fructus Chaenomelis 10～30 Borneolum Syntheticums 3～6.

6. the external application Chinese medicine for the treatment of cervical spondylosis as claimed in claim 5, prolapse of lumbar intervertebral disc, scapulohumeral periarthritis, is characterized in that it is to be prepared from by the raw material of following weight portion:

Herba clematidis intricatae 20 Herba Lycopodii 20 Radix Clematidis 20

Cortex erythrinae 20 Cortex Acanthopancis 20 Rhizoma Drynariae 20

Rhizoma Sparganii 20 Sanguis Draxonis 5 Rhizoma Chuanxiongs 15

The Radix Angelicae Dahuricae 15 Fructus Chaenomelis 12 Borneolum Syntheticums 5.

7. the external application Chinese medicine of the treatment cervical spondylosis as described in claim 4-6 any one, prolapse of lumbar intervertebral disc, scapulohumeral periarthritis, is characterized in that the preparation method of its active component comprises the following steps:

Get 11 taste medical materials except Borneolum Syntheticum, add and be equivalent to the alcohol dipping 12～48 hours that the volume by volume concentration of 1～2 times of this 11 taste medical material gross weight is 40%～60%, then the ethanol that is 40%～60% with volume by volume concentration carries out percolation with the speed that accounts for raw material total weight parts 0.2%～0.6% per minute, collection is equivalent to the percolate that this 11 taste medical material gross weight 5-10 doubly measures, reclaim ethanol, be evaporated to and be equivalent to 1～2 times of 11 taste medical material gross weights, filter, obtain medicinal liquid A;

Medicinal liquid A and Borneolum Syntheticum are active component.

8. treat a Chinese medicine for outer use for cervical spondylosis, prolapse of lumbar intervertebral disc, scapulohumeral periarthritis, comprise the Chinese medicine described in any one in claim 1-2 and pharmaceutically acceptable carrier.

9. treat a Chinese medicine for outer use for cervical spondylosis, prolapse of lumbar intervertebral disc, scapulohumeral periarthritis, comprise Chinese medicine claimed in claim 3 and pharmaceutically acceptable carrier.

10. treat a Chinese medicine for outer use for cervical spondylosis, prolapse of lumbar intervertebral disc, scapulohumeral periarthritis, comprise the Chinese medicine described in any one in claim 4-6 and pharmaceutically acceptable carrier.

Treat the Chinese medicine for outer use of cervical spondylosis, prolapse of lumbar intervertebral disc, scapulohumeral periarthritis for 11. 1 kinds, comprise Chinese medicine claimed in claim 7 and pharmaceutically acceptable carrier.

12. if the external application Chinese medicine of the treatment cervical spondylosis as described in any one, prolapse of lumbar intervertebral disc, scapulohumeral periarthritis in claim 1～2 is as the application of preparation treatment knee joint numbness medicine.

13. if the external application Chinese medicine of the treatment cervical spondylosis as described in any one, prolapse of lumbar intervertebral disc, scapulohumeral periarthritis in claim 4～6 is as the application of preparation treatment knee joint numbness medicine.

The external application Chinese medicine of 14. treatment cervical spondylosiss as claimed in claim 3, prolapse of lumbar intervertebral disc, scapulohumeral periarthritis is as the application of preparation treatment knee joint numbness medicine.

The external application Chinese medicine of 15. treatment cervical spondylosiss as claimed in claim 7, prolapse of lumbar intervertebral disc, scapulohumeral periarthritis is as the application of preparation treatment knee joint numbness medicine.