CN103535801B - A kind of health drink that there is alleviating physical fatigue and improve anoxia endurance - Google Patents
A kind of health drink that there is alleviating physical fatigue and improve anoxia endurance Download PDFInfo
- Publication number
- CN103535801B CN103535801B CN201210234925.3A CN201210234925A CN103535801B CN 103535801 B CN103535801 B CN 103535801B CN 201210234925 A CN201210234925 A CN 201210234925A CN 103535801 B CN103535801 B CN 103535801B
- Authority
- CN
- China
- Prior art keywords
- parts
- acid
- potassium
- sodium
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 206010021143 Hypoxia Diseases 0.000 title claims abstract description 30
- 206010002660 Anoxia Diseases 0.000 title claims abstract description 29
- 241000976983 Anoxia Species 0.000 title claims abstract description 29
- 230000007953 anoxia Effects 0.000 title claims abstract description 29
- 230000036541 health Effects 0.000 title claims abstract description 28
- 241001165494 Rhodiola Species 0.000 claims abstract description 35
- 240000005373 Panax quinquefolius Species 0.000 claims abstract description 33
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 33
- 240000006079 Schisandra chinensis Species 0.000 claims abstract description 33
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 33
- 240000002948 Ophiopogon intermedius Species 0.000 claims abstract description 30
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 26
- 102000007544 Whey Proteins Human genes 0.000 claims abstract description 16
- 108010046377 Whey Proteins Proteins 0.000 claims abstract description 16
- 235000021119 whey protein Nutrition 0.000 claims abstract description 16
- 238000002360 preparation method Methods 0.000 claims description 90
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 86
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 69
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 60
- 239000002253 acid Substances 0.000 claims description 60
- 239000001103 potassium chloride Substances 0.000 claims description 56
- 235000011164 potassium chloride Nutrition 0.000 claims description 56
- 235000003599 food sweetener Nutrition 0.000 claims description 51
- 239000003765 sweetening agent Substances 0.000 claims description 51
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 48
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 47
- 235000001727 glucose Nutrition 0.000 claims description 47
- 239000008103 glucose Substances 0.000 claims description 47
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 46
- 235000020357 syrup Nutrition 0.000 claims description 46
- 239000006188 syrup Substances 0.000 claims description 46
- -1 oligoisomaltose Substances 0.000 claims description 45
- 239000002994 raw material Substances 0.000 claims description 44
- 239000011780 sodium chloride Substances 0.000 claims description 30
- 235000002639 sodium chloride Nutrition 0.000 claims description 30
- 159000000000 sodium salts Chemical class 0.000 claims description 26
- 239000004310 lactic acid Substances 0.000 claims description 24
- 235000014655 lactic acid Nutrition 0.000 claims description 24
- 239000000203 mixture Substances 0.000 claims description 24
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 23
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 claims description 23
- 108010011485 Aspartame Proteins 0.000 claims description 23
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 23
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 23
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 23
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 23
- 229920002472 Starch Polymers 0.000 claims description 23
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims description 23
- 239000004376 Sucralose Substances 0.000 claims description 23
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 23
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 23
- 235000010358 acesulfame potassium Nutrition 0.000 claims description 23
- 229960004998 acesulfame potassium Drugs 0.000 claims description 23
- 239000000619 acesulfame-K Substances 0.000 claims description 23
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 23
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 23
- 239000000605 aspartame Substances 0.000 claims description 23
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 23
- 235000010357 aspartame Nutrition 0.000 claims description 23
- 229960003438 aspartame Drugs 0.000 claims description 23
- 239000001506 calcium phosphate Substances 0.000 claims description 23
- 235000015165 citric acid Nutrition 0.000 claims description 23
- WDRWZVWLVBXVOI-QTNFYWBSSA-L dipotassium;(2s)-2-aminopentanedioate Chemical compound [K+].[K+].[O-]C(=O)[C@@H](N)CCC([O-])=O WDRWZVWLVBXVOI-QTNFYWBSSA-L 0.000 claims description 23
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 23
- 239000004220 glutamic acid Substances 0.000 claims description 23
- 235000013922 glutamic acid Nutrition 0.000 claims description 23
- 235000021552 granulated sugar Nutrition 0.000 claims description 23
- 235000012907 honey Nutrition 0.000 claims description 23
- GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 claims description 23
- 239000004137 magnesium phosphate Substances 0.000 claims description 23
- 229960002261 magnesium phosphate Drugs 0.000 claims description 23
- 229910000157 magnesium phosphate Inorganic materials 0.000 claims description 23
- 235000010994 magnesium phosphates Nutrition 0.000 claims description 23
- 239000001630 malic acid Substances 0.000 claims description 23
- 235000011090 malic acid Nutrition 0.000 claims description 23
- 235000020429 malt syrup Nutrition 0.000 claims description 23
- 239000000845 maltitol Substances 0.000 claims description 23
- 235000010449 maltitol Nutrition 0.000 claims description 23
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims description 23
- 229940035436 maltitol Drugs 0.000 claims description 23
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 23
- 235000013919 monopotassium glutamate Nutrition 0.000 claims description 23
- 235000011007 phosphoric acid Nutrition 0.000 claims description 23
- 235000019698 starch Nutrition 0.000 claims description 23
- 239000008107 starch Substances 0.000 claims description 23
- 229940013618 stevioside Drugs 0.000 claims description 23
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims description 23
- 235000019202 steviosides Nutrition 0.000 claims description 23
- 235000019408 sucralose Nutrition 0.000 claims description 23
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims description 23
- 239000011975 tartaric acid Substances 0.000 claims description 23
- 235000002906 tartaric acid Nutrition 0.000 claims description 23
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 23
- 229940078499 tricalcium phosphate Drugs 0.000 claims description 23
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims description 23
- 235000019731 tricalcium phosphate Nutrition 0.000 claims description 23
- 239000000811 xylitol Substances 0.000 claims description 23
- 235000010447 xylitol Nutrition 0.000 claims description 23
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 23
- 229960002675 xylitol Drugs 0.000 claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 108010035532 Collagen Proteins 0.000 claims description 10
- 102000008186 Collagen Human genes 0.000 claims description 10
- 229920001436 collagen Polymers 0.000 claims description 10
- 102000004407 Lactalbumin Human genes 0.000 claims description 8
- 108090000942 Lactalbumin Proteins 0.000 claims description 8
- 239000006228 supernatant Substances 0.000 claims description 6
- 229920002494 Zein Polymers 0.000 claims description 5
- 239000005019 zein Substances 0.000 claims description 5
- 229940093612 zein Drugs 0.000 claims description 5
- 241000251468 Actinopterygii Species 0.000 claims description 4
- 244000068988 Glycine max Species 0.000 claims description 4
- 235000010469 Glycine max Nutrition 0.000 claims description 4
- 241000251511 Holothuroidea Species 0.000 claims description 4
- 108010038807 Oligopeptides Proteins 0.000 claims description 4
- 102000015636 Oligopeptides Human genes 0.000 claims description 4
- 108010073771 Soybean Proteins Proteins 0.000 claims description 4
- 238000011049 filling Methods 0.000 claims description 4
- 235000019710 soybean protein Nutrition 0.000 claims description 4
- MVORZMQFXBLMHM-QWRGUYRKSA-N Gly-His-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)CN)CC1=CN=CN1 MVORZMQFXBLMHM-QWRGUYRKSA-N 0.000 claims description 3
- 241000270666 Testudines Species 0.000 claims description 3
- 108010038983 glycyl-histidyl-lysine Proteins 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 claims description 3
- 108010055615 Zein Proteins 0.000 claims description 2
- 238000009835 boiling Methods 0.000 claims description 2
- 239000012467 final product Substances 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 239000008213 purified water Substances 0.000 claims description 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- 235000003704 aspartic acid Nutrition 0.000 claims 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 12
- 235000013305 food Nutrition 0.000 description 67
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 44
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 44
- 239000000546 pharmaceutical excipient Substances 0.000 description 44
- 239000006187 pill Substances 0.000 description 44
- SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 description 44
- 239000002552 dosage form Substances 0.000 description 43
- 241000699666 Mus <mouse, genus> Species 0.000 description 24
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 22
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 22
- 229960005261 aspartic acid Drugs 0.000 description 22
- 239000002775 capsule Substances 0.000 description 22
- CEYULKASIQJZGP-UHFFFAOYSA-L disodium;2-(carboxymethyl)-2-hydroxybutanedioate Chemical compound [Na+].[Na+].[O-]C(=O)CC(O)(C(=O)O)CC([O-])=O CEYULKASIQJZGP-UHFFFAOYSA-L 0.000 description 22
- 239000003937 drug carrier Substances 0.000 description 22
- BEGBSFPALGFMJI-UHFFFAOYSA-N ethene;sodium Chemical group [Na].C=C BEGBSFPALGFMJI-UHFFFAOYSA-N 0.000 description 22
- 235000013373 food additive Nutrition 0.000 description 22
- 239000002778 food additive Substances 0.000 description 22
- 238000009472 formulation Methods 0.000 description 22
- 239000008187 granular material Substances 0.000 description 22
- 235000011056 potassium acetate Nutrition 0.000 description 22
- 239000001508 potassium citrate Substances 0.000 description 22
- 229960002635 potassium citrate Drugs 0.000 description 22
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 22
- 235000011082 potassium citrates Nutrition 0.000 description 22
- 239000001632 sodium acetate Substances 0.000 description 22
- 235000017281 sodium acetate Nutrition 0.000 description 22
- 229910000029 sodium carbonate Inorganic materials 0.000 description 22
- 239000001509 sodium citrate Substances 0.000 description 22
- 229910052938 sodium sulfate Inorganic materials 0.000 description 22
- 235000011152 sodium sulphate Nutrition 0.000 description 22
- MSXHSNHNTORCAW-GGLLEASOSA-M sodium;(2s,3s,4s,5r,6s)-3,4,5,6-tetrahydroxyoxane-2-carboxylate Chemical compound [Na+].O[C@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O MSXHSNHNTORCAW-GGLLEASOSA-M 0.000 description 22
- 239000007901 soft capsule Substances 0.000 description 22
- 239000003826 tablet Substances 0.000 description 22
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 22
- 229940038773 trisodium citrate Drugs 0.000 description 22
- 235000013361 beverage Nutrition 0.000 description 19
- 230000009182 swimming Effects 0.000 description 17
- 210000004369 blood Anatomy 0.000 description 13
- 239000008280 blood Substances 0.000 description 13
- 241000699670 Mus sp. Species 0.000 description 11
- 102100026189 Beta-galactosidase Human genes 0.000 description 9
- 108010059881 Lactase Proteins 0.000 description 9
- 108010005774 beta-Galactosidase Proteins 0.000 description 9
- 229940116108 lactase Drugs 0.000 description 9
- 239000000463 material Substances 0.000 description 9
- 210000001124 body fluid Anatomy 0.000 description 8
- 239000010839 body fluid Substances 0.000 description 8
- 238000002474 experimental method Methods 0.000 description 8
- 238000003304 gavage Methods 0.000 description 8
- 239000013642 negative control Substances 0.000 description 8
- PNNCWTXUWKENPE-UHFFFAOYSA-N [N].NC(N)=O Chemical compound [N].NC(N)=O PNNCWTXUWKENPE-UHFFFAOYSA-N 0.000 description 6
- 239000001301 oxygen Substances 0.000 description 6
- 229910052760 oxygen Inorganic materials 0.000 description 6
- 210000002966 serum Anatomy 0.000 description 6
- 210000004243 sweat Anatomy 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 5
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 5
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 5
- 230000006735 deficit Effects 0.000 description 5
- 235000008434 ginseng Nutrition 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 241000432824 Asparagus densiflorus Species 0.000 description 4
- 230000037396 body weight Effects 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 231100000572 poisoning Toxicity 0.000 description 4
- 230000000607 poisoning effect Effects 0.000 description 4
- 239000013641 positive control Substances 0.000 description 4
- 230000004083 survival effect Effects 0.000 description 4
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 230000018044 dehydration Effects 0.000 description 3
- 238000006297 dehydration reaction Methods 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000003792 electrolyte Substances 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 208000028867 ischemia Diseases 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 210000003205 muscle Anatomy 0.000 description 3
- 230000029058 respiratory gaseous exchange Effects 0.000 description 3
- 241001412627 Adenophora liliifolia Species 0.000 description 2
- 241000756943 Codonopsis Species 0.000 description 2
- 229920002527 Glycogen Polymers 0.000 description 2
- 239000009636 Huang Qi Substances 0.000 description 2
- 230000002929 anti-fatigue Effects 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000009661 fatigue test Methods 0.000 description 2
- 229940096919 glycogen Drugs 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000005464 sample preparation method Methods 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 230000035900 sweating Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000012549 training Methods 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- VZQHRKZCAZCACO-PYJNHQTQSA-N (2s)-2-[[(2s)-2-[2-[[(2s)-2-[[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]prop-2-enoylamino]-3-methylbutanoyl]amino]propanoic acid Chemical group OC(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)C(=C)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCCNC(N)=N VZQHRKZCAZCACO-PYJNHQTQSA-N 0.000 description 1
- JPOKAKNGULMYHZ-UILVTTEASA-N (2s)-6-amino-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-6-amino-2-[[(2s)-2-[[(2s)-6-amino-2-[[(2s)-6-amino-2-[[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]hexanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]hexanoyl]amino]-3-(4-hydroxyp Chemical group C([C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCN=C(N)N)C1=CC=C(O)C=C1 JPOKAKNGULMYHZ-UILVTTEASA-N 0.000 description 1
- MUSGYEMSJUFFHT-UWABRSFTSA-N 2-[(4R,7S,10S,13S,19S,22S,25S,28S,31S,34R)-34-[[(2S,3S)-2-[[(2R)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-[[(2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl]-methylcarbamoyl]-25-(3-amino-3-oxopropyl)-7-(3-carbamimidamidopropyl)-10-(1H-imidazol-5-ylmethyl)-19-(1H-indol-3-ylmethyl)-13,17-dimethyl-28-[(1-methylindol-3-yl)methyl]-6,9,12,15,18,21,24,27,30,33-decaoxo-31-propan-2-yl-1,2-dithia-5,8,11,14,17,20,23,26,29,32-decazacyclopentatriacont-22-yl]acetic acid Chemical group CC[C@H](C)[C@H](NC(=O)[C@H](N)Cc1ccc(O)cc1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](C)NC(=O)CN(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2cn(C)c3ccccc23)NC(=O)[C@@H](NC1=O)C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)C(N)=O MUSGYEMSJUFFHT-UWABRSFTSA-N 0.000 description 1
- ZKHQWZAMYRWXGA-KQYNXXCUSA-J ATP(4-) Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-J 0.000 description 1
- ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 description 1
- 208000002381 Brain Hypoxia Diseases 0.000 description 1
- 201000006474 Brain Ischemia Diseases 0.000 description 1
- OBMZMSLWNNWEJA-XNCRXQDQSA-N C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 Chemical compound C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 OBMZMSLWNNWEJA-XNCRXQDQSA-N 0.000 description 1
- 206010008120 Cerebral ischaemia Diseases 0.000 description 1
- 206010014418 Electrolyte imbalance Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241000581650 Ivesia Species 0.000 description 1
- 208000007101 Muscle Cramp Diseases 0.000 description 1
- 208000010428 Muscle Weakness Diseases 0.000 description 1
- 208000029549 Muscle injury Diseases 0.000 description 1
- 206010028372 Muscular weakness Diseases 0.000 description 1
- 101710176384 Peptide 1 Proteins 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 210000004404 adrenal cortex Anatomy 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000004099 anaerobic respiration Effects 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- 230000007954 hypoxia Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000005374 membrane filtration Methods 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000002232 neuromuscular Effects 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229960003975 potassium Drugs 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- HUAUNKAZQWMVFY-UHFFFAOYSA-M sodium;oxocalcium;hydroxide Chemical compound [OH-].[Na+].[Ca]=O HUAUNKAZQWMVFY-UHFFFAOYSA-M 0.000 description 1
- 235000011496 sports drink Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/02—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation containing fruit or vegetable juices
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a kind of health drink that there is alleviating physical fatigue and improve anoxia endurance.It is prepared from by the tuber of dwarf lilyturf, the fruit of Chinese magnoliavine, dark plum, American Ginseng, rhodiola root, whey protein peptide etc.There is alleviating physical fatigue and improve the effect of anoxia endurance, the tired crowd of the tired god of the power that is applicable to, sport and body-building and summer tour in the field crowd, high-temperature operation and outwork crowd eat.
Description
Technical field
The present invention relates to a kind of health drink that there is alleviating physical fatigue and improve anoxia endurance.
Background technology
The fast pace of the modern life, make people more by time consumption in the work of bustling about, people run every day in busy work and life, and often have ignored most important health problem, health majority presents the state of one " inferior health ", namely body is without organic disease, but has the state that some functions change.According to World Health Organization's update, the whole world has the adult of 70% to be in sub-health state, and wherein, what show as battle-weary symptom accounts for more than 80%.Luckily, along with the promotion of health care in recent years, people slow busy step, and increasing general public joins the main forces of physical training in order to improve the health, because they know that a reason-health is only best capital, what carrys out happy life not have healthy health.
People, in daily physical training, can discharge sweat.Somebody thinks to have the effect of toxin expelling by the metabolic waste can discharged by sweat in body, so it is The more the better to feel to perspire.Sweat carrys out autoblood in fact, containing certain blood constituent in sweat, in sweat except some metabolic wastes, also has many materials useful to body, as mineral matter, protein, amino acid, vitamin etc.Along with the loss of sweat, these nutriments also lost thereupon.For a small amount of perspiration, can take notice of very much, but for a large amount of perspirations, just should not regard as unimportant.Perspiring because a large amount of makes body fluid reduce, if fluid infusion not in time, blood volume can be caused to decline, increased heart rate, perspire rate declines, and heat-sinking capability declines, and body temperature raises, and body electrolyte disturbance and acid-base balance, cause dehydration.Dehydration causes some major organs physiological functions of body to be affected, as heart burden, compromised kidneys.Electrolytical a large amount of loss such as sodium, potassium can cause neuro-muscular system disorders, causes the symptom such as muscle weakness, muscle cramp.Dehydration also can make locomitivity decline, and produces sense of fatigue, causes the discomfort of body.
Traditional Chinese medicine is thought, body fluid and body fluid, a large amount of perspiration easily causes body fluid to consume, if long-term a large amount of perspiration also can cause the adverse consequences such as " profuse sweating impairment of yin ", " depletion of fluid involving qi desertion ", therefore exploitation has alleviating physical fatigue and improves the product of body anoxia endurance, make people both obtain supplementing of sufficient energy and body fluid, muscle power can be made again to be restored rapidly, there is significant realistic meaning.
The present invention is at patent " a kind of raw arteries and veins sports drink and preparation method thereof " (number of patent application: the secondary innovation 201010524215.5) on basis.Its innovative point is: rhodiola root is added prescription by the present invention, effectively strengthens prescription and is improving the effect in body anoxia endurance and antifatigue.Research shows, rhodiola root can accelerate adrenal cortex and return to normal condition from depletion state, improves the oxygen supply of body tissue organ, and the hemorheological sex change change caused by suppressing anoxic realizes its oxygen lack resistant function.Rhodiola root also accelerates blood circulation by preventing the contraction of capillary, improves the adaptability to low-oxygen environment.Rhodiola root body is more saved utilize glycogen and Adenosine triphosphate capable; for muscle activity provides energy more fully; to diaphragmatic fatigue and diaphragmatic muscle damage, there is protective effect; the fatigue that a large amount of motion can be made to be formed improves; be the good ancillary drug of one of endurance exercise and the motion of resistance to speed, also can be used as health treatment and improve Healthy People aerobic capacity and anti-fatigue ability.In addition, the present invention's American Ginseng prescription, American Ginseng is cool in nature, and long-term taking can boosting qi and nourishing yin, clearing heat and promoting fluid, the body fluid of body and the recovery of physical efficiency after suitable motion.Clinical research shows, the present invention not only can supplement rapidly the loss of the rear protein of motion and body fluid, maintains body electrolyte balance, and can improve body anoxia endurance, make the rapid fatigue-relieving of body.
Summary of the invention
The object of the present invention is to provide a kind of health drink that there is alleviating physical fatigue and improve anoxia endurance, there is alleviating physical fatigue and improve the effect of anoxia endurance, the tired crowd of the tired god of the power that is applicable to, sport and body-building and summer tour in the field crowd, high-temperature operation and outwork crowd eat.
Technical scheme of the present invention:
A kind of health drink that there is alleviating physical fatigue and improve anoxia endurance, it is characterized in that mainly containing following raw material composition and weight proportion is prepared from: the tuber of dwarf lilyturf 1 ~ 30 part, 1 ~ 20 part, the fruit of Chinese magnoliavine, dark plum 1 ~ 20 part, American Ginseng 1 ~ 20 part, rhodiola root 1 ~ 20 part, whey protein peptide 1 ~ 20 part, sodium salt 0.1 ~ 2 part, sylvite 0.05 ~ 0.5 part, sweetener 0.1 ~ 120 part, acid 0.1 ~ 8 part.Preferred weight ratio range of the present invention is: the tuber of dwarf lilyturf 4 ~ 18 parts, 2 ~ 12 parts, the fruit of Chinese magnoliavine, dark plum 2 ~ 12 parts, American Ginseng 2 ~ 10 parts, rhodiola root 2 ~ 10 parts, whey protein peptide 3 ~ 15 parts, sodium salt 0.3 ~ 1.5 part, sylvite 0.1 ~ 0.35 part, sweetener 0.2 ~ 90 part, acid 0.5 ~ 4 part.Optimum weight proportioning of the present invention is: the tuber of dwarf lilyturf 8 parts, 4 parts, the fruit of Chinese magnoliavine, dark plum 4 parts, American Ginseng 3 parts, rhodiola root 3 parts, whey protein peptide 6 parts, sodium salt 0.6 part, sylvite 0.2 part, sweetener 50 parts, acid 2.5 parts.
As mentioned above, a kind of have alleviating physical fatigue and improve the health drink of anoxia endurance, it is characterized in that can changing effect into by equivalent substitutivity principle American Ginseng, cure mainly in similar ginseng, Radix Codonopsis, radix pseudostellariae or the Radix Astragali any one or more.
As mentioned above, a kind of have alleviating physical fatigue and improve the health drink of anoxia endurance, it is characterized in that can changing effect into the tuber of dwarf lilyturf by equivalent substitutivity principle, any one cured mainly in close asparagus fern, the root of straight ladybell.
As mentioned above, a kind of health drink that there is alleviating physical fatigue and improve anoxia endurance, it is characterized in that sodium salt can be any one in sodium chloride, sodium acetate, gluconic acid sodium salt, sodium sulphate, sodium ethylene diamine tetracetate, sodium carbonate, natrium citricum, trisodium citrate or several, preferred sodium chloride; Sylvite can be any one in potassium chloride, saleratus, potassium acetate, potassium citrate or several, preferred potassium chloride.
As mentioned above, there is alleviating physical fatigue and improve the health drink of anoxia endurance, it is characterized in that whey protein peptide can use any one in lactalbumin, collagen, soybean protein, zein, soybean oligopeptide, collagen peptide, fish skin collagen peptide, turtle peptide, sea cucumber peptide or several replacement.
As mentioned above, there is alleviating physical fatigue and improve the health drink of anoxia endurance, it is characterized in that sweetener can be any one or more in white granulated sugar, glucose, starch syrup, malt syrup, glucose syrup, maltitol, xylitol, antierythrite, oligoisomaltose, Sucralose, Aspartame, stevioside, acesulfame potassium or honey element; Acid can be any one or more in citric acid, malic acid, tartaric acid, lactic acid, phosphoric acid, glutamic acid, magnesium phosphate, C-aspartic acid, tricalcium phosphate, potassium glutamate.
As mentioned above, a kind of health drink that there is alleviating physical fatigue and improve anoxia endurance, it is characterized in that preparation method takes the tuber of dwarf lilyturf, the fruit of Chinese magnoliavine, dark plum, American Ginseng, rhodiola root by recipe quantity, boiling twice, 10 ~ 15 times amount that at every turn add water decoct 1 ~ 3 hour, and collecting decoction, is cooled to room temperature, centrifugal through supercentrifuge, supernatant is for subsequent use; Take lactalbumin Gly-His-Lys, sodium chloride, potassium chloride, sweetener, acid by recipe quantity again, add water and make abundant dissolving in right amount, merge with supernatant, add purified water and be settled to 1000mL, mixing, filter, filling, sterilizing, to obtain final product.
As mentioned above, there is a health drink for alleviating physical fatigue and raising anoxia endurance, it is characterized in that finished dosage forms can be the granule, tablet, capsule, soft capsule, pill, the pill that adopt pharmaceutically acceptable carrier or excipient to make.
As mentioned above, a kind of have alleviating physical fatigue and improve the health drink of anoxia endurance, it is characterized in that finished product can also be adopt acceptable excipient or food additives on food, routinely the food made of food preparation processes.
As mentioned above, a kind of have alleviating physical fatigue and improve the health drink of anoxia endurance, it is characterized in that the application in the food preparing alleviating physical fatigue and improve anoxia endurance or health products.
The invention has the advantages that:
The sport beverage formula sold in the market is single, major part adopts carbohydrate (sucrose or glucose) to add electrolyte formula, the functional component that people's physical efficiency utilizes is more single, and can not meet the demand of the anaerobic respiration that such crowd produces for profuse sweating impairment of yin, depletion of fluid involving qi desertion, strenuous exercise.We instruct, scientific compatibility, synergy, play alleviating physical fatigue, raising anoxia endurance, adjustment electrolyte balance and enhance tolerance and strength, improve the albumen synthesis of muscle, promote effect that glycogen is laid in.We can be made into sugar-free formulation product, and applicable crowd is wider, and diabetic etc. also can long-term taking.
The invention provides a kind of health drink that there is alleviating physical fatigue and improve anoxia endurance, both there is enriching yin, tonifying Qi, the effect of promoting the production of body fluid, can supplement again because motion or high temperature perspiration cause electrolytical loss, there is effect of alleviating physical fatigue and raising anoxia endurance.Modern study shows: this product can extend the mice burden swimming time, reduces the rear blood lactase acid value of mouse swimming, reduces the blood lactase acid TG-AUC after swimming, reduce mice serum urea nitrogen, the our effect with alleviating physical fatigue of prompting; In addition, originally can extend mouse Hypoxia under normal pressure, natrium nitrosum poisoning rear mouse survival time and Ischemia Injury in Brain hypoxia mice breathing time, prompting we have the effect improving anoxia endurance.
1 alleviating physical fatigue test
1.1 materials: beverage of the present invention: be prepared from by American Ginseng, the tuber of dwarf lilyturf, the fruit of Chinese magnoliavine, dark plum, rhodiola root, whey protein peptide, sodium chloride, potassium chloride etc.; Positive control: be prepared from according to prescription and preparation method in patent 201010524215.5 by ginseng, the tuber of dwarf lilyturf, the fruit of Chinese magnoliavine, dark plum, whey protein peptide, sodium chloride, potassium chloride etc.; 120 male mice in kunming, body weight 18 ~ 22g, is provided by Animal Experimental Study center, Hubei Province.
1.2 sample preparations: get beverage of the present invention, positive control drug concentrated respectively after be mixed with every milliliter in be the liquid of 0.275g containing crude drug, for beverage group of the present invention and positive controls mouse stomach, negative control group gavage gives physiological saline, and each experimental group is all by 0.20ml/10g body weight capacity gavage.
1.3 experimental techniques (1) Loaned swimming test: often organize 10 mouse, the continuous gavage of mouse 30 days, last is to 30min after tested material, and mouse tail root bears a heavy burden 5% body weight, puts swimming trunk went swimming and observes mouse from swimming to the death time.(2) mensuration of Serum lactic acid content: often organize 10 mouse, the continuous gavage of mouse 30 days, last, to 30min after tested material, puts into the water went swimming 10min of 30 DEG C, before swimming, after swimming at once, swimming have a rest after 20min get blood (endocanthion gets blood) respectively for three times and measure blood lactase acid value.(3) mensuration of serum urea nitrogen content: the continuous gavage of mouse 30 days, last, to 30min after tested material, puts into the water went swimming 90min of 30 DEG C, and after water outlet, rest 60min, eyeball gets hematometry serum urea nitrogen content.
1.4 index detection method blood lactase acid values adopt Nanjing to build up the blood lactase acid kit measurement of bio-engineering corporation's production.Kit lot number: 20110330; Determination of urea nitrogen adopts Hitachi 7020 type automatic clinical chemistry analyzer to measure.Kit lot number: 101051.
1.5 result
1.5.1 beverage of the present invention is on the impact of mice burden swimming time
Beverage of the present invention can extend the mice burden swimming time, compares with negative control group, and difference has significant difference (P<0.01), in table 1.
1.5.2 beverage of the present invention is on mouse swimming blood lactase acid value and the impact of blood lactase acid TG-AUC
Beverage of the present invention can reduce the blood lactase acid value after mouse swimming, compares have significant difference (P<0.01), in table 2 with negative control group.Meanwhile, beverage of the present invention can reduce the blood lactase acid TG-AUC of mouse swimming, compares have significant difference (P<0.01), in table 3 with negative control group.
1.5.3 beverage of the present invention is on the impact of mice serum urea nitrogen
Beverage of the present invention can reduce mice serum urea nitrogen, compares have significant difference (P<0.01), in table 4 with negative control group.
2 alleviating physical fatigue tests
2.1 materials: beverage of the present invention: be prepared from by American Ginseng, the tuber of dwarf lilyturf, the fruit of Chinese magnoliavine, dark plum, rhodiola root, whey protein peptide, sodium chloride, potassium chloride etc.; Positive control: be prepared from according to prescription and preparation method in patent 201010524215.5 by ginseng, the tuber of dwarf lilyturf, the fruit of Chinese magnoliavine, dark plum, whey protein peptide, sodium chloride, potassium chloride etc.; 144 male mice in kunming, body weight 18 ~ 22g, is provided by Animal Experimental Study center, Hubei Province.
2.2 sample preparations: with 1.2.
2.3 experimental techniques: (1) oxygen deficit tolerance is tested: often organize 12 mouse, the continuous gavage of mouse 30 days, last gives 1h after tested material, each group of mouse is put into respectively the 250ml port grinding bottle (1 every bottle) filling 5g soda lime, seal bottleneck with vaseline, cover tightly, make it air tight, manual time-keeping immediately, stops as index to breathe, observes the time of mouse death because of anoxic.(2) the poisoning survival experiment of natrium nitrosum: often organize 10 mouse, the continuous gavage of mouse 30 days, last gives 1h after tested material, and each treated animal is by 240mg/kgBW dosage lumbar injection natrium nitrosum (injection volume is 0.1ml/10gBW), manual time-keeping immediately, record animal survival time.(3) Ischemia Injury in Brain anoxic experiment: the continuous gavage of mouse 30 days, last gives 1h after tested material, each treated animal from neck by only breaking end, immediately by after stopwatch record mouse broken end to dwell time of breathing of dehiscing.
1.4 result
1.4.1 beverage of the present invention is on the impact of mouse oxygen deficit tolerance experiment time-to-live
Beverage of the present invention can obviously extend the mouse oxygen deficit tolerance time-to-live, compares have significant difference (P < 0.01), in table 5 with negative control group.
1.4.2 beverage of the present invention is on the impact of mouse natrium nitrosum poisoning survival experiment time-to-live
Beverage of the present invention obviously can extend the natrium nitrosum poisoning rear time-to-live, compares have significant difference (P < 0.01), in table 6 with negative control group.
1.4.3 beverage of the present invention affecting beverage of the present invention and obviously can extend Ischemia Injury in Brain anoxic experiment mice breathing time the Acute cerebral ischemia in mice anoxic experiment time-to-live, compare with negative control group, there is significant difference (P < 0.01), see
Table 7.
2, conclusion
Can be drawn by above pharmacological tests, beverage of the present invention has alleviating physical fatigue and improves the health care of anoxia endurance.
four, detailed description of the invention
With specific embodiment, the present invention is elaborated below:
Embodiment 1
Press column weight amount to match and get raw material: the tuber of dwarf lilyturf 2 parts, 1 part, the fruit of Chinese magnoliavine, dark plum 1.5 parts, American Ginseng 2 parts, rhodiola root 3 parts, whey protein peptide 3 parts, sodium salt 0.13 part, sylvite 0.1 part, sweetener 19 parts, acid 1.1 parts.
Preparation method: the tuber of dwarf lilyturf, the fruit of Chinese magnoliavine, dark plum, American Ginseng, rhodiola root are added 13 times of soak by water 2 hours, liquid filters, and 10 times amount that continue to add water decoct 1.5 hours, merging filtrate, and be cooled to room temperature, centrifugal, supernatant is for subsequent use.Get lactalbumin Gly-His-Lys, sodium chloride, potassium chloride, sweetener, acid, add water and make abundant dissolving in right amount, merge with supernatant, add water to 1000ml and stir, through 0.45 μm of diatomite micropore composite filter membrane filtration, filling, sterilizing.
Raw material as above, sodium chloride can use any one in sodium acetate, gluconic acid sodium salt, sodium sulphate, sodium ethylene diamine tetracetate, sodium carbonate, natrium citricum, trisodium citrate or several replacement; Potassium chloride can use any one in saleratus, potassium acetate, potassium citrate or several replacement; Sweetener can be any one or more in white granulated sugar, glucose, starch syrup, malt syrup, glucose syrup, maltitol, xylitol, antierythrite, oligoisomaltose, Sucralose, Aspartame, stevioside, acesulfame potassium or honey element; Acid can be any one or more in citric acid, malic acid, tartaric acid, lactic acid, phosphoric acid, glutamic acid, magnesium phosphate, C-aspartic acid, tricalcium phosphate, potassium glutamate.
Preparation method as above, is characterized in that finished dosage forms can be the formulation adopting pharmaceutically acceptable carrier or excipient to make, as granule, tablet, capsule, soft capsule, pill, pill.
Preparation method as above, is characterized in that finished dosage forms can also be adopt acceptable excipient or food additives on food, routinely the food made of food preparation processes.
Embodiment 2
Press column weight amount to match and get raw material: the tuber of dwarf lilyturf 28 parts, 12 parts, the fruit of Chinese magnoliavine, dark plum 17 parts, American Ginseng 15 parts, rhodiola root 18 parts, whey protein peptide 18 parts, sodium salt 0.2 part, sylvite 0.3 part, sweetener 95 parts, acid 2.5 parts.
Preparation method is with embodiment 1
Raw material as above, sodium chloride can use any one in sodium acetate, gluconic acid sodium salt, sodium sulphate, sodium ethylene diamine tetracetate, sodium carbonate, natrium citricum, trisodium citrate or several replacement; Potassium chloride can use any one in saleratus, potassium acetate, potassium citrate or several replacement; Sweetener can be any one or more in white granulated sugar, glucose, starch syrup, malt syrup, glucose syrup, maltitol, xylitol, antierythrite, oligoisomaltose, Sucralose, Aspartame, stevioside, acesulfame potassium or honey element; Acid can be any one or more in citric acid, malic acid, tartaric acid, lactic acid, phosphoric acid, glutamic acid, magnesium phosphate, C-aspartic acid, tricalcium phosphate, potassium glutamate.
Preparation method as above, is characterized in that finished dosage forms can be the formulation adopting pharmaceutically acceptable carrier or excipient to make, as granule, tablet, capsule, soft capsule, pill, pill.
Preparation method as above, is characterized in that finished dosage forms can also be adopt acceptable excipient or food additives on food, routinely the food made of food preparation processes.
Embodiment 3
Raw material is taken: the tuber of dwarf lilyturf 4 parts, 2 parts, the fruit of Chinese magnoliavine, dark plum 2.5 parts, American Ginseng 2.5 parts, rhodiola root 3 parts, whey protein peptide 4 parts, sodium salt 0.3 part, sylvite 0.15 part, sweetener 22.5 parts, acid 1.9 parts according to following proportioning.
Preparation method is with embodiment 1
Raw material as above, sodium chloride can use any one in sodium acetate, gluconic acid sodium salt, sodium sulphate, sodium ethylene diamine tetracetate, sodium carbonate, natrium citricum, trisodium citrate or several replacement; Potassium chloride can use any one in saleratus, potassium acetate, potassium citrate or several replacement; Sweetener can be any one or more in white granulated sugar, glucose, starch syrup, malt syrup, glucose syrup, maltitol, xylitol, antierythrite, oligoisomaltose, Sucralose, Aspartame, stevioside, acesulfame potassium or honey element; Acid can be any one or more in citric acid, malic acid, tartaric acid, lactic acid, phosphoric acid, glutamic acid, magnesium phosphate, C-aspartic acid, tricalcium phosphate, potassium glutamate.
Preparation method as above, is characterized in that finished dosage forms can be the formulation adopting pharmaceutically acceptable carrier or excipient to make, as granule, tablet, capsule, soft capsule, pill, pill.
Preparation method as above, is characterized in that finished dosage forms can also be adopt acceptable excipient or food additives on food, routinely the food made of food preparation processes.
Embodiment 4
Raw material is taken: the tuber of dwarf lilyturf 17 parts, 10 parts, the fruit of Chinese magnoliavine, dark plum 10.5 parts, American Ginseng 9.5 parts, rhodiola root 10 parts, whey protein peptide 14 parts, sodium salt 0.8 part, sylvite 0.25 part, sweetener 72.5 parts, acid 2.3 parts according to following proportioning.
Preparation method is with embodiment 1
Raw material as above, sodium chloride can use any one in sodium acetate, gluconic acid sodium salt, sodium sulphate, sodium ethylene diamine tetracetate, sodium carbonate, natrium citricum, trisodium citrate or several replacement; Potassium chloride can use any one in saleratus, potassium acetate, potassium citrate or several replacement; Sweetener can be any one or more in white granulated sugar, glucose, starch syrup, malt syrup, glucose syrup, maltitol, xylitol, antierythrite, oligoisomaltose, Sucralose, Aspartame, stevioside, acesulfame potassium or honey element; Acid can be any one or more in citric acid, malic acid, tartaric acid, lactic acid, phosphoric acid, glutamic acid, magnesium phosphate, C-aspartic acid, tricalcium phosphate, potassium glutamate.
Preparation method as above, is characterized in that finished dosage forms can be the formulation adopting pharmaceutically acceptable carrier or excipient to make, as granule, tablet, capsule, soft capsule, pill, pill.
Preparation method as above, is characterized in that finished dosage forms can also be adopt acceptable excipient or food additives on food, routinely the food made of food preparation processes.
Embodiment 5
Raw material is taken: the tuber of dwarf lilyturf 8 parts, 4 parts, the fruit of Chinese magnoliavine, dark plum 4 parts, American Ginseng 3 parts, rhodiola root 3 parts, whey protein peptide 6 parts, sodium salt 0.6 part, sylvite 0.2 part, sweetener 50 parts, acid 2.5 parts according to following proportioning.
Preparation method is with embodiment 1
Raw material as above, sodium chloride can use any one in sodium acetate, gluconic acid sodium salt, sodium sulphate, sodium ethylene diamine tetracetate, sodium carbonate, natrium citricum, trisodium citrate or several replacement; Potassium chloride can use any one in saleratus, potassium acetate, potassium citrate or several replacement; Sweetener can be any one or more in white granulated sugar, glucose, starch syrup, malt syrup, glucose syrup, maltitol, xylitol, antierythrite, oligoisomaltose, Sucralose, Aspartame, stevioside, acesulfame potassium or honey element; Acid can be any one or more in citric acid, malic acid, tartaric acid, lactic acid, phosphoric acid, glutamic acid, magnesium phosphate, C-aspartic acid, tricalcium phosphate, potassium glutamate.
Preparation method as above, is characterized in that finished dosage forms can be the formulation adopting pharmaceutically acceptable carrier or excipient to make, as granule, tablet, capsule, soft capsule, pill, pill.
Preparation method as above, is characterized in that finished dosage forms can also be adopt acceptable excipient or food additives on food, routinely the food made of food preparation processes.
Embodiment 6
Raw material is taken: the tuber of dwarf lilyturf 8 parts, 4 parts, the fruit of Chinese magnoliavine, dark plum 4 parts, American Ginseng 3 parts, rhodiola root 3 parts, collagen 7 parts, sodium salt 0.6 part, sylvite 0.2 part, sweetener 55 parts, acid 2.3 parts according to following proportioning.
Preparation method is with embodiment 1
Raw material as above, sodium chloride can use any one in sodium acetate, gluconic acid sodium salt, sodium sulphate, sodium ethylene diamine tetracetate, sodium carbonate, natrium citricum, trisodium citrate or several replacement; Potassium chloride can use any one in saleratus, potassium acetate, potassium citrate or several replacement; Sweetener can be any one or more in white granulated sugar, glucose, starch syrup, malt syrup, glucose syrup, maltitol, xylitol, antierythrite, oligoisomaltose, Sucralose, Aspartame, stevioside, acesulfame potassium or honey element; Acid can be any one or more in citric acid, malic acid, tartaric acid, lactic acid, phosphoric acid, glutamic acid, magnesium phosphate, C-aspartic acid, tricalcium phosphate, potassium glutamate.
Preparation method as above, is characterized in that finished dosage forms can be the formulation adopting pharmaceutically acceptable carrier or excipient to make, as granule, tablet, capsule, soft capsule, pill, pill.
Preparation method as above, is characterized in that finished dosage forms can also be adopt acceptable excipient or food additives on food, routinely the food made of food preparation processes.
Embodiment 7
Raw material is taken: the tuber of dwarf lilyturf 7.8 parts, 4 parts, the fruit of Chinese magnoliavine, dark plum 4 parts, American Ginseng 3 parts, rhodiola root 3 parts, fish skin collagen peptide 7.5 parts, sodium salt 0.6 part, sylvite 0.2 part, sweetener 58 parts, acid 2 parts according to following proportioning.
Preparation method is with embodiment 1
Raw material as above, sodium chloride can use any one in sodium acetate, gluconic acid sodium salt, sodium sulphate, sodium ethylene diamine tetracetate, sodium carbonate, natrium citricum, trisodium citrate or several replacement; Potassium chloride can use any one in saleratus, potassium acetate, potassium citrate or several replacement; Sweetener can be any one or more in white granulated sugar, glucose, starch syrup, malt syrup, glucose syrup, maltitol, xylitol, antierythrite, oligoisomaltose, Sucralose, Aspartame, stevioside, acesulfame potassium or honey element; Acid can be any one or more in citric acid, malic acid, tartaric acid, lactic acid, phosphoric acid, glutamic acid, magnesium phosphate, C-aspartic acid, tricalcium phosphate, potassium glutamate.
Preparation method as above, is characterized in that finished dosage forms can be the formulation adopting pharmaceutically acceptable carrier or excipient to make, as granule, tablet, capsule, soft capsule, pill, pill.
Preparation method as above, is characterized in that finished dosage forms can also be adopt acceptable excipient or food additives on food, routinely the food made of food preparation processes.
Embodiment 8
Raw material is taken: the tuber of dwarf lilyturf 7.8 parts, 4 parts, the fruit of Chinese magnoliavine, dark plum 4 parts, American Ginseng 3 parts, rhodiola root 3 parts, turtle peptide 6.5 parts, sodium salt 0.6 part, sylvite 0.2 part, sweetener 48 parts, acid 1.7 parts according to following proportioning.
Preparation method is with embodiment 1
Raw material as above, sodium chloride can use any one in sodium acetate, gluconic acid sodium salt, sodium sulphate, sodium ethylene diamine tetracetate, sodium carbonate, natrium citricum, trisodium citrate or several replacement; Potassium chloride can use any one in saleratus, potassium acetate, potassium citrate or several replacement; Sweetener can be any one or more in white granulated sugar, glucose, starch syrup, malt syrup, glucose syrup, maltitol, xylitol, antierythrite, oligoisomaltose, Sucralose, Aspartame, stevioside, acesulfame potassium or honey element; Acid can be any one or more in citric acid, malic acid, tartaric acid, lactic acid, phosphoric acid, glutamic acid, magnesium phosphate, C-aspartic acid, tricalcium phosphate, potassium glutamate.
Preparation method as above, is characterized in that finished dosage forms can be the formulation adopting pharmaceutically acceptable carrier or excipient to make, as granule, tablet, capsule, soft capsule, pill, pill.
Preparation method as above, is characterized in that finished dosage forms can also be adopt acceptable excipient or food additives on food, routinely the food made of food preparation processes.
Embodiment 9
Raw material is taken: the tuber of dwarf lilyturf 7.8 parts, 4 parts, the fruit of Chinese magnoliavine, dark plum 4 parts, American Ginseng 3 parts, rhodiola root 3 parts, sea cucumber peptide 9.5 parts, sodium salt 0.4 part, sylvite 0.18 part, sweetener 48 parts, acid 2 parts according to following proportioning.
Preparation method is with embodiment 1
Raw material as above, sodium chloride can use any one in sodium acetate, gluconic acid sodium salt, sodium sulphate, sodium ethylene diamine tetracetate, sodium carbonate, natrium citricum, trisodium citrate or several replacement; Potassium chloride can use any one in saleratus, potassium acetate, potassium citrate or several replacement; Sweetener can be any one or more in white granulated sugar, glucose, starch syrup, malt syrup, glucose syrup, maltitol, xylitol, antierythrite, oligoisomaltose, Sucralose, Aspartame, stevioside, acesulfame potassium or honey element; Acid can be any one or more in citric acid, malic acid, tartaric acid, lactic acid, phosphoric acid, glutamic acid, magnesium phosphate, C-aspartic acid, tricalcium phosphate, potassium glutamate.
Preparation method as above, is characterized in that finished dosage forms can be the formulation adopting pharmaceutically acceptable carrier or excipient to make, as granule, tablet, capsule, soft capsule, pill, pill.
Preparation method as above, is characterized in that finished dosage forms can also be adopt acceptable excipient or food additives on food, routinely the food made of food preparation processes.
Embodiment 10
Raw material is taken: the tuber of dwarf lilyturf 7.8 parts, 4 parts, the fruit of Chinese magnoliavine, dark plum 4 parts, American Ginseng 3 parts, rhodiola root 3 parts, zein 9.5 parts, sodium salt 0.4 part, sylvite 0.14 part, sweetener 48 parts, acid 2.2 parts according to following proportioning.
Preparation method is with embodiment 1
Raw material as above, sodium chloride can use any one in sodium acetate, gluconic acid sodium salt, sodium sulphate, sodium ethylene diamine tetracetate, sodium carbonate, natrium citricum, trisodium citrate or several replacement; Potassium chloride can use any one in saleratus, potassium acetate, potassium citrate or several replacement; Sweetener can be any one or more in white granulated sugar, glucose, starch syrup, malt syrup, glucose syrup, maltitol, xylitol, antierythrite, oligoisomaltose, Sucralose, Aspartame, stevioside, acesulfame potassium or honey element; Acid can be any one or more in citric acid, malic acid, tartaric acid, lactic acid, phosphoric acid, glutamic acid, magnesium phosphate, C-aspartic acid, tricalcium phosphate, potassium glutamate.
Preparation method as above, is characterized in that finished dosage forms can be the formulation adopting pharmaceutically acceptable carrier or excipient to make, as granule, tablet, capsule, soft capsule, pill, pill.
Preparation method as above, is characterized in that finished dosage forms can also be adopt acceptable excipient or food additives on food, routinely the food made of food preparation processes.
Embodiment 11
Raw material is taken: the tuber of dwarf lilyturf 8 parts, 4.5 parts, the fruit of Chinese magnoliavine, dark plum 5 parts, American Ginseng 3.8 parts, rhodiola root 4.3 parts, lactalbumin 9.5 parts, sodium salt 0.5 part, sylvite 0.15 part, sweetener 50 parts, acid 1.2 parts according to following proportioning.
Preparation method is with embodiment 1
Raw material as above, sodium chloride can use any one in sodium acetate, gluconic acid sodium salt, sodium sulphate, sodium ethylene diamine tetracetate, sodium carbonate, natrium citricum, trisodium citrate or several replacement; Potassium chloride can use any one in saleratus, potassium acetate, potassium citrate or several replacement; Sweetener can be any one or more in white granulated sugar, glucose, starch syrup, malt syrup, glucose syrup, maltitol, xylitol, antierythrite, oligoisomaltose, Sucralose, Aspartame, stevioside, acesulfame potassium or honey element; Acid can be any one or more in citric acid, malic acid, tartaric acid, lactic acid, phosphoric acid, glutamic acid, magnesium phosphate, C-aspartic acid, tricalcium phosphate, potassium glutamate.
Preparation method as above, is characterized in that finished dosage forms can be the formulation adopting pharmaceutically acceptable carrier or excipient to make, as granule, tablet, capsule, soft capsule, pill, pill.
Preparation method as above, is characterized in that finished dosage forms can also be adopt acceptable excipient or food additives on food, routinely the food made of food preparation processes.
Embodiment 12
Raw material is taken: the tuber of dwarf lilyturf 7 parts, 4 parts, the fruit of Chinese magnoliavine, dark plum 4.5 parts, American Ginseng 4 parts, rhodiola root 5 parts, soybean protein 9 parts, sodium salt 0.45 part, sylvite 0.17 part, sweetener 42 parts, acid 1.5 parts according to following proportioning.
Preparation method is with embodiment 1
Raw material as above, sodium chloride can use any one in sodium acetate, gluconic acid sodium salt, sodium sulphate, sodium ethylene diamine tetracetate, sodium carbonate, natrium citricum, trisodium citrate or several replacement; Potassium chloride can use any one in saleratus, potassium acetate, potassium citrate or several replacement; Sweetener can be any one or more in white granulated sugar, glucose, starch syrup, malt syrup, glucose syrup, maltitol, xylitol, antierythrite, oligoisomaltose, Sucralose, Aspartame, stevioside, acesulfame potassium or honey element; Acid can be any one or more in citric acid, malic acid, tartaric acid, lactic acid, phosphoric acid, glutamic acid, magnesium phosphate, C-aspartic acid, tricalcium phosphate, potassium glutamate.
Preparation method as above, is characterized in that finished dosage forms can be the formulation adopting pharmaceutically acceptable carrier or excipient to make, as granule, tablet, capsule, soft capsule, pill, pill.
Preparation method as above, is characterized in that finished dosage forms can also be adopt acceptable excipient or food additives on food, routinely the food made of food preparation processes.
Embodiment 13
Raw material is taken: the tuber of dwarf lilyturf 6 parts, 2 parts, the fruit of Chinese magnoliavine, dark plum 4 parts, American Ginseng 3 parts, rhodiola root 3 parts, soybean oligopeptide 6 parts, sodium salt 0.55 part, sylvite 0.15 part, sweetener 40 parts, acid 3 parts according to following proportioning.
Preparation method is with embodiment 1
Raw material as above, sodium chloride can use any one in sodium acetate, gluconic acid sodium salt, sodium sulphate, sodium ethylene diamine tetracetate, sodium carbonate, natrium citricum, trisodium citrate or several replacement; Potassium chloride can use any one in saleratus, potassium acetate, potassium citrate or several replacement; Sweetener can be any one or more in white granulated sugar, glucose, starch syrup, malt syrup, glucose syrup, maltitol, xylitol, antierythrite, oligoisomaltose, Sucralose, Aspartame, stevioside, acesulfame potassium or honey element; Acid can be any one or more in citric acid, malic acid, tartaric acid, lactic acid, phosphoric acid, glutamic acid, magnesium phosphate, C-aspartic acid, tricalcium phosphate, potassium glutamate.
Preparation method as above, is characterized in that finished dosage forms can be the formulation adopting pharmaceutically acceptable carrier or excipient to make, as granule, tablet, capsule, soft capsule, pill, pill.
Preparation method as above, is characterized in that finished dosage forms can also be adopt acceptable excipient or food additives on food, routinely the food made of food preparation processes.
Embodiment 14
Raw material is taken: the tuber of dwarf lilyturf 10 parts, 3 parts, the fruit of Chinese magnoliavine, dark plum 6 parts, American Ginseng 4 parts, rhodiola root 6 parts, collagen peptide 9 parts, sodium salt 0.4 part, sylvite 0.12 part, sweetener 48 parts, acid 1.2 parts according to following proportioning.
Preparation method is with embodiment 1
Raw material as above, sodium chloride can use any one in sodium acetate, gluconic acid sodium salt, sodium sulphate, sodium ethylene diamine tetracetate, sodium carbonate, natrium citricum, trisodium citrate or several replacement; Potassium chloride can use any one in saleratus, potassium acetate, potassium citrate or several replacement; Sweetener can be any one or more in white granulated sugar, glucose, starch syrup, malt syrup, glucose syrup, maltitol, xylitol, antierythrite, oligoisomaltose, Sucralose, Aspartame, stevioside, acesulfame potassium or honey element; Acid can be any one or more in citric acid, malic acid, tartaric acid, lactic acid, phosphoric acid, glutamic acid, magnesium phosphate, C-aspartic acid, tricalcium phosphate, potassium glutamate.
Preparation method as above, is characterized in that finished dosage forms can be the formulation adopting pharmaceutically acceptable carrier or excipient to make, as granule, tablet, capsule, soft capsule, pill, pill.
Preparation method as above, is characterized in that finished dosage forms can also be adopt acceptable excipient or food additives on food, routinely the food made of food preparation processes.
Embodiment 15
Raw material is taken: asparagus fern 7.8 parts, 4 parts, the fruit of Chinese magnoliavine, dark plum 4 parts, ginseng 3 parts, rhodiola root 3 parts, zein 9.5 parts, sodium salt 0.4 part, sylvite 0.14 part, sweetener 48 parts, acid 2.6 parts according to following proportioning.
Preparation method is with embodiment 1
Raw material as above, sodium chloride can use any one in sodium acetate, gluconic acid sodium salt, sodium sulphate, sodium ethylene diamine tetracetate, sodium carbonate, natrium citricum, trisodium citrate or several replacement; Potassium chloride can use any one in saleratus, potassium acetate, potassium citrate or several replacement; Sweetener can be any one or more in white granulated sugar, glucose, starch syrup, malt syrup, glucose syrup, maltitol, xylitol, antierythrite, oligoisomaltose, Sucralose, Aspartame, stevioside, acesulfame potassium or honey element; Acid can be any one or more in citric acid, malic acid, tartaric acid, lactic acid, phosphoric acid, glutamic acid, magnesium phosphate, C-aspartic acid, tricalcium phosphate, potassium glutamate.
Preparation method as above, is characterized in that finished dosage forms can be the formulation adopting pharmaceutically acceptable carrier or excipient to make, as granule, tablet, capsule, soft capsule, pill, pill.
Preparation method as above, is characterized in that finished dosage forms can also be adopt acceptable excipient or food additives on food, routinely the food made of food preparation processes.
Embodiment 16
Raw material is taken: the root of straight ladybell 8 parts, 4.5 parts, the fruit of Chinese magnoliavine, dark plum 5 parts, American Ginseng 3.8 parts, rhodiola root 4.3 parts, lactalbumin 9.5 parts, sodium salt 0.5 part, sylvite 0.15 part, sweetener 50 parts, acid 2.2 parts according to following proportioning.
Preparation method is with embodiment 1
Raw material as above, sodium chloride can use any one in sodium acetate, gluconic acid sodium salt, sodium sulphate, sodium ethylene diamine tetracetate, sodium carbonate, natrium citricum, trisodium citrate or several replacement; Potassium chloride can use any one in saleratus, potassium acetate, potassium citrate or several replacement; Sweetener can be any one or more in white granulated sugar, glucose, starch syrup, malt syrup, glucose syrup, maltitol, xylitol, antierythrite, oligoisomaltose, Sucralose, Aspartame, stevioside, acesulfame potassium or honey element; Acid can be any one or more in citric acid, malic acid, tartaric acid, lactic acid, phosphoric acid, glutamic acid, magnesium phosphate, C-aspartic acid, tricalcium phosphate, potassium glutamate.
Preparation method as above, is characterized in that finished dosage forms can be the formulation adopting pharmaceutically acceptable carrier or excipient to make, as granule, tablet, capsule, soft capsule, pill, pill.
Preparation method as above, is characterized in that finished dosage forms can also be adopt acceptable excipient or food additives on food, routinely the food made of food preparation processes.
Embodiment 17
Raw material is taken: the tuber of dwarf lilyturf 7 parts, 4 parts, the fruit of Chinese magnoliavine, dark plum 4.5 parts, ginseng 4 parts, rhodiola root 5 parts, soybean protein 9 parts, sodium salt 0.45 part, sylvite 0.17 part, sweetener 42 parts, acid 2.5 parts according to following proportioning.
Preparation method is with embodiment 1
Raw material as above, sodium chloride can use any one in sodium acetate, gluconic acid sodium salt, sodium sulphate, sodium ethylene diamine tetracetate, sodium carbonate, natrium citricum, trisodium citrate or several replacement; Potassium chloride can use any one in saleratus, potassium acetate, potassium citrate or several replacement; Sweetener can be any one or more in white granulated sugar, glucose, starch syrup, malt syrup, glucose syrup, maltitol, xylitol, antierythrite, oligoisomaltose, Sucralose, Aspartame, stevioside, acesulfame potassium or honey element; Acid can be any one or more in citric acid, malic acid, tartaric acid, lactic acid, phosphoric acid, glutamic acid, magnesium phosphate, C-aspartic acid, tricalcium phosphate, potassium glutamate.
Preparation method as above, is characterized in that finished dosage forms can be the formulation adopting pharmaceutically acceptable carrier or excipient to make, as granule, tablet, capsule, soft capsule, pill, pill.
Preparation method as above, is characterized in that finished dosage forms can also be adopt acceptable excipient or food additives on food, routinely the food made of food preparation processes.
Embodiment 18
Raw material is taken: the tuber of dwarf lilyturf 6 parts, 2 parts, the fruit of Chinese magnoliavine, dark plum 4 parts, Radix Codonopsis 3 parts, rhodiola root 3 parts, soybean oligopeptide 6 parts, sodium salt 0.55 part, sylvite 0.15 part, sweetener 40 parts, acid 1.9 parts according to following proportioning.
Preparation method is with embodiment 1
Raw material as above, sodium chloride can use any one in sodium acetate, gluconic acid sodium salt, sodium sulphate, sodium ethylene diamine tetracetate, sodium carbonate, natrium citricum, trisodium citrate or several replacement; Potassium chloride can use any one in saleratus, potassium acetate, potassium citrate or several replacement; Sweetener can be any one or more in white granulated sugar, glucose, starch syrup, malt syrup, glucose syrup, maltitol, xylitol, antierythrite, oligoisomaltose, Sucralose, Aspartame, stevioside, acesulfame potassium or honey element; Acid can be any one or more in citric acid, malic acid, tartaric acid, lactic acid, phosphoric acid, glutamic acid, magnesium phosphate, C-aspartic acid, tricalcium phosphate, potassium glutamate.
Preparation method as above, is characterized in that finished dosage forms can be the formulation adopting pharmaceutically acceptable carrier or excipient to make, as granule, tablet, capsule, soft capsule, pill, pill.
Preparation method as above, is characterized in that finished dosage forms can also be adopt acceptable excipient or food additives on food, routinely the food made of food preparation processes.
Embodiment 19
Raw material is taken: asparagus fern 8 parts, 3 parts, the fruit of Chinese magnoliavine, dark plum 5 parts, radix pseudostellariae 4 parts, rhodiola root 5 parts, zein 9 parts, sodium salt 0.4 part, sylvite 0.12 part, sweetener 48 parts, acid 1.8 parts according to following proportioning.
Preparation method is with embodiment 1
Raw material as above, sodium chloride can use any one in sodium acetate, gluconic acid sodium salt, sodium sulphate, sodium ethylene diamine tetracetate, sodium carbonate, natrium citricum, trisodium citrate or several replacement; Potassium chloride can use any one in saleratus, potassium acetate, potassium citrate or several replacement; Sweetener can be any one or more in white granulated sugar, glucose, starch syrup, malt syrup, glucose syrup, maltitol, xylitol, antierythrite, oligoisomaltose, Sucralose, Aspartame, stevioside, acesulfame potassium or honey element; Acid can be any one or more in citric acid, malic acid, tartaric acid, lactic acid, phosphoric acid, glutamic acid, magnesium phosphate, C-aspartic acid, tricalcium phosphate, potassium glutamate.
Preparation method as above, is characterized in that finished dosage forms can be the formulation adopting pharmaceutically acceptable carrier or excipient to make, as granule, tablet, capsule, soft capsule, pill, pill.
Preparation method as above, is characterized in that finished dosage forms can also be adopt acceptable excipient or food additives on food, routinely the food made of food preparation processes.
Embodiment 20
Raw material is taken: asparagus fern 7 parts, 2.5 parts, the fruit of Chinese magnoliavine, dark plum 5 parts, radix pseudostellariae 4 parts, rhodiola root 5 parts, sea cucumber peptide 9 parts, sodium salt 0.4 part, sylvite 0.12 part, sweetener 60 parts, acid 2 parts according to following proportioning.
Preparation method is with embodiment 1
Raw material as above, sodium chloride can use any one in sodium acetate, gluconic acid sodium salt, sodium sulphate, sodium ethylene diamine tetracetate, sodium carbonate, natrium citricum, trisodium citrate or several replacement; Potassium chloride can use any one in saleratus, potassium acetate, potassium citrate or several replacement; Sweetener can be any one or more in white granulated sugar, glucose, starch syrup, malt syrup, glucose syrup, maltitol, xylitol, antierythrite, oligoisomaltose, Sucralose, Aspartame, stevioside, acesulfame potassium or honey element; Acid can be any one or more in citric acid, malic acid, tartaric acid, lactic acid, phosphoric acid, glutamic acid, magnesium phosphate, C-aspartic acid, tricalcium phosphate, potassium glutamate.
Preparation method as above, is characterized in that finished dosage forms can be the formulation adopting pharmaceutically acceptable carrier or excipient to make, as granule, tablet, capsule, soft capsule, pill, pill.
Preparation method as above, is characterized in that finished dosage forms can also be adopt acceptable excipient or food additives on food, routinely the food made of food preparation processes.
Embodiment 21
Raw material is taken: the tuber of dwarf lilyturf 7 parts, 2.5 parts, the fruit of Chinese magnoliavine, dark plum 5 parts, the Radix Astragali 4 parts, rhodiola root 5 parts, fish skin collagen peptide 3 parts, lactalbumin 3 parts, sodium salt 0.4 part, sylvite 0.12 part, sweetener 62 parts, acid 2 parts according to following proportioning.
Preparation method is with embodiment 1
Raw material as above, sodium chloride can use any one in sodium acetate, gluconic acid sodium salt, sodium sulphate, sodium ethylene diamine tetracetate, sodium carbonate, natrium citricum, trisodium citrate or several replacement; Potassium chloride can use any one in saleratus, potassium acetate, potassium citrate or several replacement; Sweetener can be any one or more in white granulated sugar, glucose, starch syrup, malt syrup, glucose syrup, maltitol, xylitol, antierythrite, oligoisomaltose, Sucralose, Aspartame, stevioside, acesulfame potassium or honey element; Acid can be any one or more in citric acid, malic acid, tartaric acid, lactic acid, phosphoric acid, glutamic acid, magnesium phosphate, C-aspartic acid, tricalcium phosphate, potassium glutamate.
Preparation method as above, is characterized in that finished dosage forms can be the formulation adopting pharmaceutically acceptable carrier or excipient to make, as granule, tablet, capsule, soft capsule, pill, pill.
Preparation method as above, is characterized in that finished dosage forms can also be adopt acceptable excipient or food additives on food, routinely the food made of food preparation processes.
Claims (3)
1. the health drink that there is alleviating physical fatigue and improve anoxia endurance, it is characterized in that being prepared from by following raw material composition and weight proportion: the tuber of dwarf lilyturf 8 parts, 4 parts, the fruit of Chinese magnoliavine, dark plum 4 parts, American Ginseng 3 parts, rhodiola root 3 parts, whey protein peptide 6 parts, sodium salt 0.6 part, sylvite 0.2 part, sweetener 50 parts, acid 2.5 parts; Take the tuber of dwarf lilyturf, the fruit of Chinese magnoliavine, dark plum, American Ginseng, rhodiola root during preparation, boiling twice, 10 ~ 15 times amount that at every turn add water decoct 1 ~ 3 hour, and collecting decoction, is cooled to room temperature, centrifugal through supercentrifuge, and supernatant is for subsequent use; Take lactalbumin Gly-His-Lys, sodium chloride, potassium chloride, sweetener, acid by recipe quantity again, add water and make abundant dissolving in right amount, merge with supernatant, add purified water and be settled to 1000mL, mixing, filter, filling, sterilizing, to obtain final product.
2. a kind of as claimed in claim 1 have alleviating physical fatigue and improve the health drink of anoxia endurance, it is characterized in that whey protein peptide can use any one in lactalbumin, collagen, soybean protein, zein, soybean oligopeptide, collagen peptide, fish skin collagen peptide, turtle peptide, sea cucumber peptide or several replacement.
3. a kind of as claimed in claim 1 have alleviating physical fatigue and improve the health drink of anoxia endurance, it is characterized in that sweetener can be any one or more in white granulated sugar, glucose, starch syrup, malt syrup, glucose syrup, maltitol, xylitol, antierythrite, oligoisomaltose, Sucralose, Aspartame, stevioside, acesulfame potassium or honey element; Acid can be any one or more in citric acid, malic acid, tartaric acid, lactic acid, phosphoric acid, glutamic acid, magnesium phosphate, ASPARTIC ACID, tricalcium phosphate, potassium glutamate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210234925.3A CN103535801B (en) | 2012-07-09 | 2012-07-09 | A kind of health drink that there is alleviating physical fatigue and improve anoxia endurance |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210234925.3A CN103535801B (en) | 2012-07-09 | 2012-07-09 | A kind of health drink that there is alleviating physical fatigue and improve anoxia endurance |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103535801A CN103535801A (en) | 2014-01-29 |
| CN103535801B true CN103535801B (en) | 2016-04-20 |
Family
ID=49959963
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210234925.3A Active CN103535801B (en) | 2012-07-09 | 2012-07-09 | A kind of health drink that there is alleviating physical fatigue and improve anoxia endurance |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103535801B (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104138000A (en) * | 2014-07-29 | 2014-11-12 | 陆佩 | Method for making qi-tonifying and health-maintaining soup |
| CN105029447B (en) * | 2015-08-11 | 2019-03-22 | 湖南科尔生物技术有限公司 | A kind of ocean fish oligopeptide powder containing active probiotic |
| CN105211881A (en) * | 2015-11-19 | 2016-01-06 | 哈尔滨圣吉药业股份有限公司 | A kind of health food and production method thereof with develop immunitypty function |
| CN106333356A (en) * | 2016-04-14 | 2017-01-18 | 安徽华瑞医药技术开发有限公司 | Functional food for improving anoxia endurance of athletes |
| CN106343544A (en) * | 2016-06-08 | 2017-01-25 | 安徽华瑞医药技术开发有限公司 | Functional food capable of relieving chronic fatigue syndrome |
| CN107691952A (en) * | 2017-08-22 | 2018-02-16 | 北京同仁堂健康药业股份有限公司 | A kind of resisting kinetic fatigue, the composition for promoting postexercise recovery and preparation method thereof |
| CN107853622A (en) * | 2017-11-17 | 2018-03-30 | 荣成奥汛海洋生物科技有限公司 | One kind improves anoxia endurance and chews piece and preparation method thereof |
| WO2019191947A1 (en) * | 2018-04-04 | 2019-10-10 | 浙江泛亚生物医药股份有限公司 | Isaria cicadae miquel-hippophae fructus sports drinks and preparation method therefor |
| CN110559354A (en) * | 2019-09-02 | 2019-12-13 | 西南科技大学 | Compound rhodiola rosea composition and preparation method thereof |
| CN113397076A (en) * | 2021-06-25 | 2021-09-17 | 长春帮尔保健食品有限公司 | Traditional Chinese medicine beverage composition and preparation method thereof |
| CN115153032B (en) * | 2022-05-25 | 2022-12-06 | 北京东方红航天生物技术股份有限公司 | Composition for promoting health of sports people and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101263907A (en) * | 2008-04-25 | 2008-09-17 | 北京市科威华食品工程技术有限公司 | Common stonecrop herb fatigue-resistance health care beverage and preparation thereof |
| CN101623120A (en) * | 2008-07-08 | 2010-01-13 | 张殿明 | American ginseng cola beverage and production method thereof |
| CN102090692A (en) * | 2010-09-06 | 2011-06-15 | 山东好当家海洋发展股份有限公司 | Oyster polypeptide anti-fatigue beverage and preparation method thereof |
| CN102450718A (en) * | 2010-10-29 | 2012-05-16 | 钟虹光 | Pulse sports beverage and preparation method thereof |
| CN102524872A (en) * | 2012-02-02 | 2012-07-04 | 福建康之味食品工业有限公司 | Ginseng peptide amino acid drink |
-
2012
- 2012-07-09 CN CN201210234925.3A patent/CN103535801B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101263907A (en) * | 2008-04-25 | 2008-09-17 | 北京市科威华食品工程技术有限公司 | Common stonecrop herb fatigue-resistance health care beverage and preparation thereof |
| CN101623120A (en) * | 2008-07-08 | 2010-01-13 | 张殿明 | American ginseng cola beverage and production method thereof |
| CN102090692A (en) * | 2010-09-06 | 2011-06-15 | 山东好当家海洋发展股份有限公司 | Oyster polypeptide anti-fatigue beverage and preparation method thereof |
| CN102450718A (en) * | 2010-10-29 | 2012-05-16 | 钟虹光 | Pulse sports beverage and preparation method thereof |
| CN102524872A (en) * | 2012-02-02 | 2012-07-04 | 福建康之味食品工业有限公司 | Ginseng peptide amino acid drink |
Non-Patent Citations (3)
| Title |
|---|
| 乳清制品与保健饮料;翁秀花;《中国食品工业》;19990630(第06期);46-47 * |
| 增强免疫力、缓解体力疲劳保健饮料的研制;戴晶晶等;《食品科技》;20080320(第03期);98-100 * |
| 西洋参保健饮料的研制;邓茉香等;《食品工业科技》;20060325(第03期);126-128 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103535801A (en) | 2014-01-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103535801B (en) | A kind of health drink that there is alleviating physical fatigue and improve anoxia endurance | |
| CN102090692B (en) | Oyster polypeptide anti-fatigue beverage and preparation method thereof | |
| CN102150692B (en) | Biscuit with function of curing diabetes and preparation method thereof | |
| CN102048210A (en) | Red-date health protection beverage with function of alleviating fatigue | |
| CN106418545A (en) | Functional food with balanced nutrients | |
| CN103919227B (en) | A kind of maize oligopeptide beverage with memory reinforcing effect and production technology thereof | |
| CN103005558A (en) | Spleen tonifying and appetite promoting drink and preparation method thereof | |
| CN106497751A (en) | A kind of compound assembled alcoholic drinks of sealwort oyster and preparation method | |
| CN108175024A (en) | A kind of sunflower flower powder solid beverage and preparation method | |
| CN101669624B (en) | Chinese medicinal assorted Chinese herbal tea with function of improving woman anemia and preparation method thereof | |
| CN102113534B (en) | Moon cake with function of treating diabetes and preparation method thereof | |
| CN108740620A (en) | A kind of prune clear beverage and preparation method thereof | |
| US20160199431A1 (en) | Composition with anoxia-tolerant and anti-fatigue effects and use thereof | |
| CN110432493A (en) | A kind of red ginseng composition, its application and red ginseng composite beverage | |
| CN113855766A (en) | Gingko and cordyceps militaris granules capable of regulating blood pressure | |
| CN102106577B (en) | Natural and organic beverage capable of improving male sleep quality | |
| CN103238889A (en) | Anti-fatigue apple vinegar health beverage and preparation method thereof | |
| CN103349121A (en) | Hyperglycemia-hyperlipidemia-hypertension relieving health protection tea and preparation method thereof | |
| CN101756227A (en) | Chinese wolfberry health tea and processing method thereof | |
| CN101253986B (en) | Multifunctional nutrition composite health care drink and method of preparing the same | |
| CN102150844B (en) | Dried noodles with function of treating diabetes and preparation method of dried noodles | |
| CN106581292A (en) | Longzu paste and preparation method thereof | |
| CN102113668B (en) | Quick-frozen boiled dumplings applicable to diabetes and preparation method thereof | |
| CN103584244A (en) | Preparation method of heat clearing and lung moistening beverage | |
| CN103156956A (en) | Blood replenishing oral liquid and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20170308 Address after: 330096 Jiangxi city of Nanchang province Wanli District Zhaoxian Road No. 1 River Valley Patentee after: JIANGXI JIANGZHONG DIETOTHERAPY TECHNOLOGY Co.,Ltd. Address before: 330096 Nanchang high tech Zone, Jiangxi Torch Road, No. 788 Patentee before: Zhong Hongguang |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20210804 Address after: 332020 No.188 Chaoyang Avenue, Gongqing high tech Zone, Jiujiang City, Jiangxi Province Patentee after: Jiangzhong dietotherapy Technology Co.,Ltd. Address before: 330096 jiangzhongyao Valley, No.1, Zhaoxian Road, Wanli District, Nanchang City, Jiangxi Province Patentee before: JIANGXI JIANGZHONG DIETOTHERAPY TECHNOLOGY Co.,Ltd. |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A health drink that can alleviate physical fatigue and improve hypoxia tolerance Effective date of registration: 20231127 Granted publication date: 20160420 Pledgee: Jiangxi Guofang Asset Operation Co.,Ltd. Pledgor: Jiangzhong dietotherapy Technology Co.,Ltd. Registration number: Y2023980067616 |