CN103535574A - Royal jelly composition and preparation method thereof - Google Patents
Royal jelly composition and preparation method thereof Download PDFInfo
- Publication number
- CN103535574A CN103535574A CN201210243301.8A CN201210243301A CN103535574A CN 103535574 A CN103535574 A CN 103535574A CN 201210243301 A CN201210243301 A CN 201210243301A CN 103535574 A CN103535574 A CN 103535574A
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- China
- Prior art keywords
- royal jelly
- weight portions
- composition
- vitamin
- seed extract
- Prior art date
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- 229930195729 fatty acid Natural products 0.000 description 1
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- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 1
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- 229940035034 maltodextrin Drugs 0.000 description 1
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- HGVVOUNEGQIPMS-UHFFFAOYSA-N procyanidin Chemical compound O1C2=CC(O)=CC(O)=C2C(O)C(O)C1(C=1C=C(O)C(O)=CC=1)OC1CC2=C(O)C=C(O)C=C2OC1C1=CC=C(O)C(O)=C1 HGVVOUNEGQIPMS-UHFFFAOYSA-N 0.000 description 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000000754 repressing effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
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- 239000000377 silicon dioxide Substances 0.000 description 1
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- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000011122 softwood Substances 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
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- 238000007619 statistical method Methods 0.000 description 1
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- 235000000346 sugar Nutrition 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
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- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 210000003606 umbilical vein Anatomy 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 239000010497 wheat germ oil Substances 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L21/00—Marmalades, jams, jellies or the like; Products from apiculture; Preparation or treatment thereof
- A23L21/20—Products from apiculture, e.g. royal jelly or pollen; Substitutes therefor
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a royal jelly composition and a preparation method thereof. The composition is prepared from royal jelly lyophilized powder, L-carnitine, grape seed extract, vitamin C and vitamin E succinate. The preparation method comprises the following steps: mixing L-carnitine, grape seed extract and vitamin E succinate; adding ethanol, and mixing to prepare a soft material; pelletizing, drying and granulating; adding royal jelly lyophilized powder and vitamin C, uniformly mixing, and tabletting. The invention also provides application of the royal jelly composition in preparation of medicaments for relieving physical fatigue.
Description
Technical field
The present invention relates to a kind of composition and method of making the same, particularly the preparation method of a kind of royal jelly composition and tablet thereof.
Background technology
The energy " exhaustion " theory for tired mechanism: energy is mainly derived from sugar, fat, protein and aerobic or anaerobic metabolism, along with the prolongation of run duration, energy substance exhausted, body can not maintain predetermined strength, has occurred fatigue.
Royal jelly is by a kind of milky or the flaxen corpus mamillare of worker bee Shang the hypopharyngeal gland secretion of growing up, and contains outside three large nutritions, also contains vitamin, several mineral materials, various bioactivators; The main function of l-cn is that the form with fat phthalein carnitine is transported to LCFA in film from mitochondrial membrane as carrier, carries out beta oxidation, produce power in mitochondria; L-cn can regulate acyl group ratio in mitochondria, can also be able to participate in the transportation of branched-chain amino acid metabolite, guarantees normal energetic supersession; L-cn can be discharged excessive in body or irrational acyl group group, eliminates body because of the metabolism toxicity that acyl group accumulation causes, and can also promote the oxidation of second phthalein acetic acid, in the elimination of ketoboidies with in utilizing, works, and prevents the toxicity that in animal body, excess ammonia produces; L-cn can be used as biological anti-oxidant and removes free radical, maintains the stable of film, improve animal immunity and disease-resistant anti-stress ability; Grape seed extract contains OPC, Tea Polyphenols and three kinds of compositions of natural VE, is a kind of free radical scavenger, high-performance bio antioxidant; Vitamin C is heavy polyphenoils in the inside and outside chemical reaction of human body cell, in cellular oxidation defence, play an important role, participate in and promote that between collagen and tissue, cementin forms, co-factor or the auxiliary substrate of plurality of enzymes, can strengthen body to infectious disease resistivity, improve adaptive capacity, humoral immunity, cellular immunity are all had to important regulative; Vitamin E also claims " tocopherol ", belongs to liposoluble vitamin.Vitamin E can suppress the generation of free radical, and Human Umbilical Vein Endothelial Cells has important protective effect, can maintain the stable of endothelial cell endocrine function.
In the prior art, application number is in the Chinese invention patent of CN201010168399.6, disclose and adopted 29 kinds of raw materials such as grape juice, grape pip juice, SOD, glutathione, nucleotides, royal jelly through front and back fermenting twice, to manufacture the technology of SOD grape health care wine, made this product can play the effect that strengthens body immunity and resistance; In the Chinese invention patent that is CN200410009332.2 at application number, disclose a kind of food with health role containing pollen, royal jelly, grape seed extract, this product has the multi-efficiencies such as auxiliary beauty treatment, delaying senility, raising immunity; In the Chinese invention patent that is CN200510019602.2 at application number, a kind of health honey concentrated juice is disclosed, its formulation weight percentage is honey, rice vinegar, grape juice, royal jelly dried powder, the functions such as this product has liver-protecting and alcoholism-relieving, skin maintenance, anti-ageing, defaecation is secret, softening blood vessel; In the Chinese invention patent that is CN200510123935.X at application number, disclose a kind of health products with radiation-resisting functional and preparation method thereof, it is to take the composition that the extracts such as gadol extract, grape seed extract, royal jelly freeze-dried powder, propolis are component; In the Chinese invention patent that is CN200910081850.8 at application number, a kind of nutraceutical with anti-oxidation function and preparation method thereof is disclosed, mainly by following medicine and food raw materials, made: stone column ginseng, chrysanthemum, Sessileflower Acanthopanax Bark tea, Poria cocos, Semen sesami nigrum, peach kernel, Bee Pollen, white fungus, black fungus, Hericium erinaceus, mushroom, grape pip, lycopene, royal jelly, this product has obvious oxidation resistant effect, can also improve immunity simultaneously; In the Chinese invention patent that is CN02157385.9 at application number, disclose a kind of adjusting blood fat composition, said composition is comprised of royal jelly freeze-dried powder, rape pollen, propolis, vitamin C, maltodextrin; In the Chinese invention patent that is CN200910117322.3 at application number, disclose a kind of for improving or control mankind subhealth symptom, anti-ageing oral agents, adopt honey, royal jelly, inosine, vitaminAD, vitamin C, B1, B2, licorzinc combination formula, anti-ageing for improving inferior health; In the Chinese invention patent that is CN200510036965.7 at application number, disclose a kind of snail health products, by following raw material, made: snail freeze-dried powder, royal jelly freeze-dried powder, vitamin C, dietary fiber have been, galactolipin; In the Chinese invention patent that is CN200510114726.9 at application number, a kind of nutrient that prevents sudden death is disclosed, linoleic acid, the leukotrienes of pure natural of take is matrix, take tocopheronic acid as powerful antioxidant, with the best of breed of the nutrients such as normal, trace elements K, calcium, magnesium, zinc, selenium and vitamin V A, VC, VE and royal jelly, honey, algal polysaccharides, collagen, make the nutrient of a kind of nutrition " cardiac muscle ", " heart and brain " cell, prevention sudden death; In the Chinese invention patent that is CN200810224200.X at application number, disclose a kind of for preventing inborn defect and improving the pharmaceutical composition of remembering, comprise the bighead atractylodes rhizome, royal jelly, vitamin A, beta carotene, vitamin B compound, vitamin C, vitamin D, vitamin E and macroelement calcium, magnesium, mainly be applicable to pregnant front women, pregnant woman, wet nurse, in prevention inborn defect with improve aspect memory very effective; In the Chinese invention patent that is CN200910039183.7 at application number, disclose a kind of health food that strengthens body immunity and supplementary mineral matter function that has, comprised following component: FOS, taurine, aloe extract, royal jelly, pollen, vitamin C, lysine, alanine, mineral mixture; In the Chinese invention patent that is CN200610163286.0 at application number, disclose a kind of health food with fat-reducing and anti-oxidation function, by grape seed extract, oolong tea extract, l-cn, wheat-germ oil, made; In the Chinese invention patent that is CN200910061078.3 at application number, disclose and a kind ofly can be applicable to women's body shaping, gynaecologic antibiotic anti-inflammatory, improve the preparation of women's life quality, by l-cn, collagen, amino acid, grape pip, chamomile, Sodium Benzoate, Nano silver solution, water miscible Laurocapram, carbomer, propane diols, cordate telosma essence etc., formed.In paper < < combined L-carnitine and acetyl-L-carnitine compound formulation and vitamin E use in conjunction, on the affecting in > > of idiopathic asthénospermie sperm quality, combined L-carnitine and acetyl-L-carnitine compound formulation and the impact of vitamin E use in conjunction on idiopathic asthénospermie sperm quality have been recorded, at paper < < vitamin E and l-cn, improve in the clinical observation > > of Maintenance Hemodialysis Patients renal anemia, recorded vitamin E and l-cn (VBT) effect in uremic renal anemia treatment, at paper < < Effects of L-carnitine, royal jelly and pomegranate seed on peripheral blood cells in rats > >, < < Support therapy with integrators after varicocelectomy > >, in < < Ergogenic aids:Sports performance effect of a nutritional complex > >, recorded the correlative study of royal jelly and l-cn combination, at paper < < Chronic dietary supplementation of proanthocyanidins corrects the mitochondrial dysfunction of brown adipose tissue caused by diet-induced obesity in Wistar rats > >, < < Proanthocyanidins modulate triglyceride secretion by repressing the expression of long chain acyl-CoA synthetases in Caco2 intestinal cells > >, < < A grape polyphenol extract modulates muscle membrane fatty acid composition and lipid metabolism in high-fathigh-sucrose diet-fed rats > >, < < Use of complementary and alternative medicine among adults with skin disease > >, < < Nutrient supplementation approaches in the treatment of ADHD > >, < < Effect of lycopene on cyclophosphamide-induced hemorrhagic cystitis in rats > >, < < Dietary procyanidins lower triglyceride levels signaling through the nuclear receptor small heterodimer partner > >, < < Effect of grape seed water extract on lipid metabolism and erythrocyte antioxidant defense system in high-fat diet-induced obese C57BL/6 mice > >, < < Natural compounds:Evidence for a protective role in eye disease > >, < < Patterns of usage of complementary and alternative medicine in general surgicalpatients > >, in < < Nutritional issues and supplements in amyotrophic lateral sclerosis and other neurodegenerative disorders > >, recorded the correlative study of l-cn and grape pip combination.
At present, in the prior art, relating to royal jelly, l-cn, grape pip or vitamin, to have the document of health care a lot, but it is less to relate to the report of mutual combination of these several raw materials, and there is no above-mentioned raw materials optimum organization is brought into play to synergistic research and report.
Summary of the invention
The object of the invention is to provide a kind of royal jelly composition, and another object of the present invention is to provide the Preparation method and use of said composition.
The present invention seeks to be achieved through the following technical solutions
The raw material of royal jelly composition of the present invention consists of:
Royal jelly freeze-dried powder 60-100 weight portion, l-cn 60-100 weight portion, grape seed extract 30-80 weight portion, vitamin C 10-40 weight portion, VE-succinate 5-30 weight portion.
Above-mentioned raw materials preferred weight proportioning is as follows:
Royal jelly freeze-dried powder 83.3 weight portions, l-cn 83.3 weight portions, grape seed extract 50 weight portions, Catergen 5 weight portions, VE-succinate 16.7 weight portions.
Above-mentioned raw materials preferred weight proportioning is as follows:
Royal jelly freeze-dried powder 72 weight portions, l-cn 90 weight portions, grape seed extract 43 weight portions, Catergen 9 weight portions, VE-succinate 12 weight portions.
Above-mentioned raw materials preferred weight proportioning is as follows:
Royal jelly freeze-dried powder 91 weight portions, l-cn 72 weight portions, grape seed extract 57 weight portions, Catergen 1 weight portion, VE-succinate 20 weight portions.
Above-mentioned raw materials adds conventional auxiliary material, makes the formulation of mentioning in acceptable capsule, tablet, pill, granule, powder, liquid preparation or other any pharmacies according to common process.
The concrete preparation method of royal jelly composition tablet of the present invention is as follows:
Get raw material l-cn, grape seed extract, VE-succinate, mixes with the microcrystalline cellulose of 80-90 weight portion, adds 80% ethanol, crosses 20 eye mesh screens and granulates; Fluidized drying 40-60 minute, after naturally cooling to room temperature, crosses the whole grain of 20 mesh sieves; Add royal jelly freeze-dried powder, vitamin C, mix, compressing tablet, makes tablet.
Royal jelly composition of the present invention significantly relieve chronic is tired, strengthens body tolerance, obviously slows down damage and the tired generation of free radical, alleviating physical fatigue.
Following experimental example and embodiment are used for further illustrating but are not limited to the present invention.
Experimental example 1 exercise tolerance experiment
1. experiment purpose
By exercise tolerance, test (mouse swimming test), observe the antifatigue effect of royal jelly composition of the present invention, for determining that formula consumption provides experimental basis.
2. experiment material and reagent
2.1 for reagent thing
Prescription one (G1): royal jelly freeze-dried powder 83.3g;
Prescription two (G2): l-cn 83.3g;
Prescription three (G3): grape seed extract 50g;
Prescription four (G4): vitamin C 25g;
Prescription five (G5): VE-succinate 16.7g;
Prescription six (G6): royal jelly freeze-dried powder 83.3g, l-cn 83.3g;
Prescription seven (G7): royal jelly freeze-dried powder 83.3g, grape seed extract 50g;
Prescription eight (G8): royal jelly freeze-dried powder 83.3g, l-cn 83.3g, grape seed extract 50g;
Prescription nine (G9): royal jelly freeze-dried powder 83.3g, l-cn 83.3g, VE-succinate 16.7g
Prescription ten (G10): l-cn 83.3g, grape seed extract 50g;
Prescription 11 (G11): l-cn 83.3g, vitamin C 25g;
Prescription 12 (G12): l-cn 83.3g, grape seed extract 50g, vitamin C 25g;
Prescription 13 (G13): royal jelly freeze-dried powder 83.3g, l-cn 83.3g, grape seed extract 50g, vitamin C 25g;
Prescription 14 (G14): royal jelly freeze-dried powder 83.3g, l-cn 83.3g, grape seed extract 50g, VE-succinate 16.7g;
Prescription 15 (G15): l-cn 83.3g, grape seed extract 50g, vitamin C 25g, VE-succinate 16.7g;
Prescription 13 (G13): royal jelly freeze-dried powder 83.3g, grape seed extract 50g, Catergen 5g, VE-succinate 16.7g;
Prescription 14 (G14): royal jelly freeze-dried powder 83.3g, l-cn 83.3g, vitamin C 25g, VE-succinate 16.7g;
Prescription 15 (G15): royal jelly freeze-dried powder 83.3g, l-cn 83.3g, grape seed extract 50g, vitamin C 25g;
Prescription 16 (G16): royal jelly freeze-dried powder 83.3g, l-cn 83.3g, grape seed extract 50g, vitamin C 25g, VE-succinate 16.7g;
Prescription 17 (G17): royal jelly freeze-dried powder 72g, l-cn 90g, grape seed extract 43g, Catergen 9g, VE-succinate 12g;
Prescription 18 (G18): royal jelly freeze-dried powder 91g, l-cn 72g, grape seed extract 57g, Catergen 1g, VE-succinate 20g;
Prescription 19 (G19): royal jelly freeze-dried powder 60g, l-cn 100g, grape seed extract 30g, vitamin C 40g, VE-succinate 30g.
Prescription 20 (G20): royal jelly freeze-dried powder 100g, l-cn 60g, grape seed extract 80g, vitamin C 10g, VE-succinate 5g.
2.2 reagent:
Liver/muscle glycogen testing cassete, builds up institute of biological products purchased from Nanjing;
The concentrated sulfuric acid (AR), Nanjing Chemistry Reagent Co., Ltd.;
Physiological saline, Shangdong Changfu Jiejing Pharmaceutical Industry Co., Ltd..
3. animal used as test
ICR mouse, ♂, clean level, body weight 18-22g ，You Yangzhou University's comparative medicine center provides,
The quality certification number: SCXK(Soviet Union) 2007 – 0001, the free diet of experimental session mouse.
4. key instrument
Aluminum swimming trunk (50cm * 50cm * 40cm), galvanized wire, low-temperature and high-speed centrifuge: 5804R Xing， Eppendrof company; Water-bath: DK-S26 type, the grand experimental facilities of upper Nereid Co., Ltd; Electronic scale: BS224S Xing， Sartorius company; Stopwatch, thermometer
5. experiment grouping
5.1 dosage groupings and given the test agent give the time
Mouse is divided into 21 groups at random, 10 every group, the 1st group to the 20th group medicine of giving respectively G1～G20, the 21st group is blank group, gives isopyknic distilled water, every group of every average daily gavage 1 time, gavage volume is 0.2ml/10g, gives continuously given the test agent 30 days.
5.2 sample preparation
The 1st group to the 20th group: take 2.25g drug sample, with distilled water, be assigned to 150ml;
Blank group: distilled water 150ml.
6. experimental technique
After 6.1 swimmings with a load attached to the body experiments last administration 30min, put mouse in swimming trunk, the depth of water is no less than 30cm, 25 ± 1 ℃ of water temperatures, and the load sheet lead of 5% body weight of mouse root of the tail portion, records mouse swimming and starts to the dead time, as mouse swimming time.
6.2 mice serum urea are measured after last administration 30min, in temperature, be not swimming with a load attached to the body 90min in the water of 30 ℃, after rest 60min, pluck eyeball blood sampling 0.5mL (not adding anti-coagulants), put 4 ℃ of refrigerator 3h, the centrifugal 15min of 2000r/min after blood clotting, gets serum and send First People's Hospital, Lianyungang clinical laboratory to detect.
After the mensuration last administration 30min of 6.3 hepatic glycogen, in temperature, be not swimming with a load attached to the body 90min in the water of 25 ± 1 ℃, mouse is put to death in cervical vertebra dislocation, with physiological saline, clean, and with after filter paper suck dry moisture, accurately taking liver 100mg, hepatic glycogen detection kit detects Mouse Liver glycogen content.
After the mensuration last administration 30min of 6.4 blood lactic acid, take a blood sample, then do not bear a heavy burden and stop after temperature is the water went swimming 10min of 30 ℃.Lactic acid instrument assay method: respectively before swimming, after swimming, the 20 μ L that respectively take a blood sample after rest 20min after swimming add in 40 μ L rupture of membranes liquid, the smudge cells that fully vibrates is immediately measured with lactic acid instrument.(blood lactic acid TG-AUC=5 * (the blood Lactate of the rear 20min of blood Lactate+2 * swimming of the rear 0min of blood Lactate+3 * swimming before swimming)
7. observation index swimming with a load attached to the body time, blood lactic acid, urea, glycogen initial value
8. statistical method experimental data is used
represent, employing t check is compared between organizing
9. experimental result
The impact of 9.1 present compositions on Mouse Weight
Each organizes mouse after giving G1～G20 medicine, before, in, shown in post-weight sees the following form respectively, initial body weight and weightening finish body weight and the more equal no difference of science of statistics of control group (P > 0.05) that each organizes mouse, show that G1～G20 medicine is all without obvious toxicity.Experimental result refers to table 1.
The initial body weight of table 1 swimming with a load attached to the body experiment mice, mid-term body weight and finish body weight
The impact of 9.2 present compositions on the mice burden swimming time
Per os gives after mouse G1～G20 medicine, G1～G15 medicine and the comparison of blank group, the mice burden swimming time can obviously be extended, there is significant difference (P < 0.05), present composition G16～G20 medicine and the comparison of blank group, can the significant prolongation mice burden swimming time, there is utmost point significant difference (P < 0.01), and be obviously better than G1～G15 medicine.The results detailed in Table 2.
The impact of table 2 royal jelly composition of the present invention on the mice burden swimming time
" * " p<0.05vs blank; " * * " p<0.01vs blank;
The impact of 9.3 present compositions on blood lactic acid before and after mouse movement
Per os gives after mouse royal jelly composition of the present invention, present composition G16～G20 medicine to mouse movement after blood lactic acid TG-AUC and control group relatively have significant difference (P < 0.05), though G1～G15 medicine group Mouse Blood lactic acid TG-AUC and control group comparison decrease, and no difference of science of statistics (P > 0.05).The results are shown in Table 3.
The impact of table 3 royal jelly composition of the present invention on blood lactate level before and after mouse movement
" * " p<0.05vs blank;
The impact of 9.4 present compositions on Mouse Liver glycogen
Per os gives after mouse G1～G20 medicine, G1～G15 medicine and the comparison of blank group, Mouse Liver glycogen content all has obvious rising, there is significant difference (P < 0.05), present composition G16～G20 medicine with the comparison of blank group, Mouse Liver glycogen content all has obvious rising, has utmost point significant difference (P < 0.01), and is obviously better than G1～G15 medicine.The results detailed in Table 4.The impact of table 4 royal jelly composition of the present invention on Mouse Liver glycogen content
" * " p<0.05vs blank; " * * " p<0.01vs blank;
The impact of 9.5 present compositions on mice serum urea
Per os gives after mouse G1～G20 medicine, G1～G15 medicine group and the comparison of blank group, after mouse movement, serum urea content all has obvious reduction, there is significant difference (P < 0.05), present composition G16～G20 medicine with the comparison of blank group, after mouse movement, serum urea content all has obvious reduction all to have obvious reduction, has utmost point significant difference (P < 0.01), and is obviously better than G1～G15 medicine.The results detailed in Table 5.
The impact of table 5 royal jelly composition of the present invention on mice serum urea content
" * " p<0.05vs blank; " * * " p<0.01vs blank;
10. experiment conclusion
This experiment is mainly tested by mice burden swimming, and the deposit that simultaneously detects Mouse Liver glycogen is observed the antifatigue effect of royal jelly composition of the present invention.Preliminary Results shows below:
1, G16～G20 composition of the present invention all can extend the mice burden swimming time (P < 0.01), and successful is better than the composition of other G1～G15.
2, biochemistry detection aspect shows, each dosage group of G16～G20 composition of the present invention all can reduce the lactic acid content that in the rear mice serum of motion, glucose anerobic glycolysis produces, relatively there is significant difference (P < 0.05) with control group, and although the composition of other G1～G15 also can reduce the lactic acid content that in the rear mice serum of motion, glucose anerobic glycolysis produces, but with control group comparison, no difference of science of statistics (P > 0.05);
3, each dosage group of G16～G20 composition of the present invention all can significantly improve the deposit (P < 0.01) of glycogen in mouse liver, and successful is better than the composition of other G1～G15;
4, high lithemia model is found, G16～G20 composition of the present invention can significantly reduce the content (P < 0.01) of the rear urea in serum of mouse swimming, and successful is better than the composition of other G1～G15;
11. discuss
Above-mentionedly experimental results show that the present composition can significantly reduce the content of urea in serum and lactic acid after mouse movement, and can significantly improve the deposit of glycogen in mouse liver, point out it by the metabolism of two large main energy matter protein and glucose in minimizing energetic supersession, to reduce the loss of energy, contribute to alleviate the fatigue that exercise load causes; Can extend the time that mice burden swimming to power exhausts.
Present composition primary raw material is royal jelly freeze-dried powder, for tired generation mechanism, has also added l-cn, grape seed extract, vitamin C, vitamin E, has the health care of alleviating physical fatigue.Add l-cn to play facilitation in Power supply step, for alleviating organism fatigue, play effect effectively.Add grape seed extract alleviating physical fatigue effectively; grape pip procyanidin can be protected and stable vitamin C; and contribute to ascorbic absorption; thereby reduce vitamin E free radical and make vitamin E regeneration reduce the loss of vitamin E in cell; strengthen the normal antioxidant level of body that maintains, slow tired generation.Can obviously slow down damage and the tired generation of free radical, help alleviating physical fatigue.
Following embodiment all can realize the effect described in above-mentioned experimental example.
The preparation of embodiment 1 royal jelly composition tablet
Royal jelly freeze-dried powder 83.3g l-cn 83.3g grape seed extract 50g
Catergen 5g VE-succinate 16.7g
Make 1000, tablet (every heavy 0.35g)
Get above-mentioned l-cn, grape seed extract, VE-succinate, mixes with the microcrystalline cellulose of 85g, adds 80% ethanol, crosses 20 eye mesh screens and granulates; Fluidized drying 40-60 minute, after naturally cooling to room temperature, crosses the whole grain of 20 mesh sieves; Add royal jelly freeze-dried powder, vitamin C, mix, compressing tablet, makes tablet.
The preparation of embodiment 2 royal jelly composition tablets
Royal jelly freeze-dried powder 72g, l-cn 90g, grape seed extract 43g, Catergen 9g, VE-succinate 12g.
Get above-mentioned royal jelly freeze-dried powder, l-cn, grape seed extract, VE-succinate, vitamin C, mix, add one or more in the dilution such as silica, dextrin, starch, phosphate, carbonate, sweet mellow wine, sorbierite, sorbic acid or sylvite, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol auxiliary material, dry, pulverize, sieve, compressing tablet, makes tablet.
The preparation of embodiment 3 royal jelly composition tablets
Royal jelly freeze-dried powder 91g, l-cn 72g, grape seed extract 57g, Catergen 1g, VE-succinate 20g.
Get above-mentioned l-cn, grape seed extract, VE-succinate, mixes with the microcrystalline cellulose of 81g, adds suitable 75% ethanol, mixes, and makes softwood, granulates, dry, and whole grain, adds royal jelly freeze-dried powder, vitamin C, mixes compressing tablet.
The preparation of embodiment 4 royal jelly composition hard shell capsules
Royal jelly freeze-dried powder 83.3g l-cn 83.3g grape seed extract 50g Catergen 5g
VE-succinate 16.7g.
Get above-mentioned raw materials, add conventional auxiliary material, encapsulated according to common process, obtain.
The preparation of embodiment 5 royal jelly composition pills
Royal jelly freeze-dried powder 72g, l-cn 90g, grape seed extract 43g, Catergen 9g, VE-succinate 12g.
Get above-mentioned raw materials, add conventional auxiliary material, according to common process pill, obtain.
The preparation of embodiment 6 royal jelly composition oral liquid
Royal jelly freeze-dried powder 91g, l-cn 72g, grape seed extract 57g, Catergen 1g, VE-succinate 20g.
Get above-mentioned raw materials, add conventional auxiliary material, according to common process, make oral liquid.
The preparation of embodiment 7 royal jelly composition softs
Royal jelly freeze-dried powder 85g, l-cn 65g, grape seed extract 70g, vitamin C 30g, VE-succinate 28g.
Get above-mentioned raw materials, add conventional auxiliary material, according to common process, make soft capsule.
The preparation of embodiment 8 royal jelly composition powders
Royal jelly freeze-dried powder 60g, l-cn 100g, grape seed extract 30g, vitamin C 40g, VE-succinate 30g.
Get above-mentioned raw materials, add conventional auxiliary material, according to common process, make powder.
The preparation of embodiment 9 royal jelly composition grains
Royal jelly freeze-dried powder 100g, l-cn 60g, grape seed extract 80g, vitamin C 10g, VE-succinate 5g.
Get above-mentioned raw materials, add conventional auxiliary material, according to common process, granulation.
Claims (7)
1. a royal jelly composition, is characterized in that the raw material of said composition consists of:
Royal jelly freeze-dried powder 60-100 weight portion, l-cn 60-100 weight portion, grape seed extract 30-80 weight portion, vitamin C 10-40 weight portion, VE-succinate 5-30 weight portion.
2. royal jelly composition as claimed in claim 1, is characterized in that the raw material of said composition consists of:
Royal jelly freeze-dried powder 83.3 weight portions, l-cn 83.3 weight portions, grape seed extract 50 weight portions, vitamin C 25 weight portions, VE-succinate 16.7 weight portions.
3. royal jelly composition as claimed in claim 1, is characterized in that the raw material of said composition consists of:
Royal jelly freeze-dried powder 72 weight portions, l-cn 90 weight portions, grape seed extract 43 weight portions, Catergen 9 weight portions, VE-succinate 12 weight portions.
4. royal jelly composition as claimed in claim 1, is characterized in that the raw material of said composition consists of:
Royal jelly freeze-dried powder 91 weight portions, l-cn 72 weight portions, grape seed extract 57 weight portions, Catergen 1 weight portion, VE-succinate 20 weight portions.
5. the preparation method of the royal jelly composition as described in claim 1,2,3 or 4, is characterized in that the method comprises the following steps:
Get raw material and add conventional auxiliary material, according to common process, make the formulation of mentioning in acceptable capsule, tablet, pill, granule, powder, liquid preparation or other any pharmacies.
6. the preparation method of the royal jelly composition tablet as described in claim 1,2,3 or 4, is characterized in that the method comprises the following steps:
Get raw material l-cn, grape seed extract, VE-succinate, mixes with the microcrystalline cellulose of 80-90 weight portion, adds 80% ethanol, crosses 20 eye mesh screens and granulates; Fluidized drying 40-60 minute, after naturally cooling to room temperature, crosses the whole grain of 20 mesh sieves; Add royal jelly freeze-dried powder, vitamin C, mix, compressing tablet, makes tablet.
7. the royal jelly composition as described in claim 1,2,3 or 4 is being prepared relieve chronic fatigue, the application in the medicine of enhancing body tolerance.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1593191A (en) * | 2004-07-14 | 2005-03-16 | 北京东方兴企食品工业技术有限公司 | Pollen, bee milk food and its preparation method |
| CN100998411A (en) * | 2006-12-18 | 2007-07-18 | 东北虎药业股份有限公司 | Health-care food with anti-oxidation and lowering weight functions |
| CN101518336A (en) * | 2009-04-14 | 2009-09-02 | 北京惠中铭捷生物科技有限公司 | Nutrition food with oxidation resistance function and preparation method thereof |
| CN101810336A (en) * | 2010-04-30 | 2010-08-25 | 广东仙乐制药有限公司 | Chewable soft capsules and method for preparing same |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1593191A (en) * | 2004-07-14 | 2005-03-16 | 北京东方兴企食品工业技术有限公司 | Pollen, bee milk food and its preparation method |
| CN100998411A (en) * | 2006-12-18 | 2007-07-18 | 东北虎药业股份有限公司 | Health-care food with anti-oxidation and lowering weight functions |
| CN101518336A (en) * | 2009-04-14 | 2009-09-02 | 北京惠中铭捷生物科技有限公司 | Nutrition food with oxidation resistance function and preparation method thereof |
| CN101810336A (en) * | 2010-04-30 | 2010-08-25 | 广东仙乐制药有限公司 | Chewable soft capsules and method for preparing same |
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