CN103520681B - A kind of Chinese medicine for the treatment of yang deficiency of spleen and stomache chronic colitis - Google Patents
A kind of Chinese medicine for the treatment of yang deficiency of spleen and stomache chronic colitis Download PDFInfo
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Abstract
The present invention relates to the Chinese medicine for the treatment of yang deficiency of spleen and stomache chronic colitis, effectively can solve the medication problem for the treatment of yang deficiency of spleen and stomache chronic colitis, its technical scheme solved is, this Chinese medicine is by following weighing scale: Radix Codonopsis 12-18g, Radix Astragali Preparata 27-33g, Poria 12-18g, Rhizoma Atractylodis Macrocephalae 9-15g, Fructus Psoraleae 12-18g, Fructus Schisandrae Chinensis 4-8g, Semen Myristicae 4-8g, Zhu's Wu cornel 2-4g, Arillus Longan 12-18g, Rhizoma Dioscoreae 27-33g, Pseudobulbus Bletillae (Rhizoma Bletillae) 17-23g, Herba Portulacae 27-33g, Fructus Amomi 6-12g, Pericarpium Citri Reticulatae 9-15g, Rhizoma Zingiberis 4-8g and Radix Glycyrrhizae Preparata 4-8g forms, the present invention has warming and recuperating the spleen and kidney, intestine-stabling and anti-diarrheal, warming middle-JIAO residence is puckery, effect of regulating QI intestinal stasis relieving, be effective to treatment yang deficiency of spleen and stomache chronic colitis, good effect, drug safety, it is the innovation on treatment yang deficiency of spleen and stomache chronic colitis medicine.
Description
Technical field
The present invention relates to medicine, particularly a kind of Chinese medicine for the treatment of yang deficiency of spleen and stomache chronic colitis.
Background technology
Chronic colitis is a kind of cause of disease rectum still not fully aware of and colon chronic nonspecific inflammation disease, and pathological changes is mainly limited to colorectal mucosa and Submucosa, and clinical manifestation is diarrhoea, mucus bloody purulent stool, stomachache.State of an illness weight not etc., many chronic courses of disease in recurrent exerbation.Primary disease treatment difficulty is large, and there is certain relation with the morbidity of colon cancer, is classified as one of modern difficult treatment by World Health Organization (WHO).
Modern medicine it be unclear that its etiology and pathology pathogenesis system, and research relatively lags behind, cause clinical treatment slow curative effect and lack specificity, at present to the therapeutic purposes of colitis be induction and maintainable remission, Therapeutic Principle controls symptom as early as possible for active stage; Catabasis maintaining treatment, control recurrence; Prevent and treat complication, perform the operation in time if desired.
The integrative therapy means of current colitis are various, have drug oral (dosage form has decoct, pill, pellet, tablet etc.), plug anus, coloclysis, acupuncture and additive method as hydrotherapy, abdomen bag, air-flow disperse, recombination energy, stem cell transplantation etc.Clinical treatment still lacks satisfied Therapeutic Method, and the medicine that western medicine is conventional has minosalicylates, drugs, corticosteroid, immunomodulator, antibiotic etc.Base acid salicylic acid is the first-line drug for the treatment of UC, but headache may be there is, feel sick in a few patients, stomachache, erythra, dizziness and arthralgia, the untoward reaction such as hepatorenal damage.Adrenocortical hormone is still the classical medicine for the treatment of UC active stage, and being also that serious symptom UC choice drug is normal share with minosalicylates, drugs, but this kind of medicine has the danger and rebound phenomenon of bringing out or increase the weight of infection.Chinese medicine report is more, have that heat-clearing and toxic substances removing, heat clearing and damp drying, regulating QI row are wet, expelling wind and dampness, regulating QI to relieve pain, invigorating the spleen and benefiting QI, spleen invigorating suppressing the hyperactive liver, reinforcing spleen and kidney, removing the necrotic tissue and promoting granulation, blood circulation promoting and blood stasis dispelling, detoxification and removing stasis, astringing to arrest bleeding, removing heat from blood and promoting blood circulation, warming YANG and invigorating QI etc., be summed up and how control from spleen, liver, kidney opinion, control from wet, heat, void, opinion of becoming silted up, but clinical efficacy is not etc., and therapeutic effect is not good.Therefore, the improvement for the treatment of yang deficiency of spleen and stomache chronic colitis medicine is the problem needing solution at present badly.
Summary of the invention
For above-mentioned situation, for solving the defect of prior art, the object of the present invention is just to provide a kind of Chinese medicine for the treatment of yang deficiency of spleen and stomache chronic colitis, effectively can solve the medication problem for the treatment of yang deficiency of spleen and stomache chronic colitis.
The technical scheme that the present invention solves is that this Chinese medicine is by following weighing scale: Radix Codonopsis 12-18g, Radix Astragali Preparata 27-33g, Poria 12-18g, Rhizoma Atractylodis Macrocephalae 9-15g, Fructus Psoraleae 12-18g, Fructus Schisandrae Chinensis 4-8g, Semen Myristicae 4-8g, Zhu's Wu cornel 2-4g, Arillus Longan 12-18g, Rhizoma Dioscoreae 27-33g, Pseudobulbus Bletillae (Rhizoma Bletillae) 17-23g, Herba Portulacae 27-33g, Fructus Amomi 6-12g, Pericarpium Citri Reticulatae 9-15g, Rhizoma Zingiberis 4-8g and Radix Glycyrrhizae Preparata 4-8g form.
Chinese medicine of the present invention is granule or oral liquid, or makes the one of tablet, decoction, powder, pill, powder according to a conventional method.
The present invention has effect of warming and recuperating the spleen and kidney, intestine-stabling and anti-diarrheal, puckery, the regulating QI intestinal stasis relieving of warming middle-JIAO residence, is effective to treatment yang deficiency of spleen and stomache chronic colitis, good effect, drug safety, is the innovation on treatment yang deficiency of spleen and stomache chronic colitis medicine.
Detailed description of the invention
Below in conjunction with embodiment, the specific embodiment of the present invention is described in further detail.
Embodiment 1
This Chinese medicine is by following weighing scale: Radix Codonopsis 12g, Radix Astragali Preparata 27g, Poria 12g, Rhizoma Atractylodis Macrocephalae 9g, Fructus Psoraleae 12g, Fructus Schisandrae Chinensis 4g, Semen Myristicae 4g, Zhu's Wu cornel 2g, Arillus Longan 12g, Rhizoma Dioscoreae 27g, Pseudobulbus Bletillae (Rhizoma Bletillae) 17g, Herba Portulacae 27g, Fructus Amomi 6g, Pericarpium Citri Reticulatae 9g, Rhizoma Zingiberis 4g and Radix Glycyrrhizae Preparata 4g form.
Embodiment 2
This Chinese medicine is by following weighing scale: Radix Codonopsis 15g, Radix Astragali Preparata 30g, Poria 15g, Rhizoma Atractylodis Macrocephalae 12g, Fructus Psoraleae 15g, Fructus Schisandrae Chinensis 6g, Semen Myristicae 6g, Zhu's Wu cornel 3g, Arillus Longan 15g, Rhizoma Dioscoreae 30g, Pseudobulbus Bletillae (Rhizoma Bletillae) 20g, Herba Portulacae 30g, Fructus Amomi 9g, Pericarpium Citri Reticulatae 12g, Rhizoma Zingiberis 6g and Radix Glycyrrhizae Preparata 6g form.
Embodiment 3
This Chinese medicine is by following weighing scale: Radix Codonopsis 18g, Radix Astragali Preparata 33g, Poria 18g, Rhizoma Atractylodis Macrocephalae 15g, Fructus Psoraleae 18g, Fructus Schisandrae Chinensis 8g, Semen Myristicae 8g, Zhu's Wu cornel 4g, Arillus Longan 18g, Rhizoma Dioscoreae 33g, Pseudobulbus Bletillae (Rhizoma Bletillae) 23g, Herba Portulacae 33g, Fructus Amomi 12g, Pericarpium Citri Reticulatae 15g, Rhizoma Zingiberis 8g and Radix Glycyrrhizae Preparata 8g form.
Embodiment 4
This Chinese medicine is by following weighing scale: Radix Codonopsis 12-15g, Radix Astragali Preparata 27-30g, Poria 12-15g, Rhizoma Atractylodis Macrocephalae 9-12g, Fructus Psoraleae 12-15g, Fructus Schisandrae Chinensis 4-6g, Semen Myristicae 4-6g, Zhu's Wu cornel 2-2.5g, Arillus Longan 12-15g, Rhizoma Dioscoreae 27-30g, Pseudobulbus Bletillae (Rhizoma Bletillae) 17-20g, Herba Portulacae 27-30g, Fructus Amomi 6-9g, Pericarpium Citri Reticulatae 9-12g, Rhizoma Zingiberis 4-6g and Radix Glycyrrhizae Preparata 4-6g form.
Embodiment 5
This Chinese medicine is by following weighing scale: Radix Codonopsis 16-18g, Radix Astragali Preparata 31-33g, Poria 16-18g, Rhizoma Atractylodis Macrocephalae 13-15g, Fructus Psoraleae 16-18g, Fructus Schisandrae Chinensis 7-8g, Semen Myristicae 7-8g, Zhu's Wu cornel 3-4g, Arillus Longan 16-18g, Rhizoma Dioscoreae 31-33g, Pseudobulbus Bletillae (Rhizoma Bletillae) 21-23g, Herba Portulacae 31-33g, Fructus Amomi 10-12g, Pericarpium Citri Reticulatae 13-15g, Rhizoma Zingiberis 7-8g and Radix Glycyrrhizae Preparata 7-8g form.
Chronic colitis yang deficiency of spleen and stomache be clinical in one of the most common pattern of syndrome, mostly be the course of disease comparatively of a specified duration, acute attack alternately occurs with alleviating, and the course of disease is longer, recurrent exerbation, clinically mainly to suffer from diarrhoea with borborygmus, rush down after then peace, coldness of the body with chills for feature.Because its Clinical symptoms is resembling of one deficiency and coldness, treatment should with " dry spleen, the kidney warming, acid receipts, astringent or styptic treatment for spontaneous sweating, ascending " five methods for controlling.At weakness of the spleen and stomach especially deficiency of spleen-YANG and kidneyYANG stage, disease based in healthy energy thanks to, often few evil without stagnant, or naivete is without stagnant, patient's condition loses intestinal cunning based on this, must reverse patient's condition while righting, make it to turn puckery by logical, medication puckeryly should should not be led to, moderately apply the medicine of relieving diarrhea with astringents.
The present invention is in conjunction with clinical treatment experience, according to (chronic colitis) etiology and pathogenesis of having loose bowels, done by the features such as clinical manifestation, the present invention closes the evolution of SISHEN WAN plus-minus by decoction of four noble drugs and forms, stress warming and recuperating the spleen and kidney and antidiarrheal, warming and recuperating the spleen and kidney, relieving diarrhea with astringents, in instant component, wherein, Fructus Psoraleae of the present invention, Fructus Evodiae, Semen Myristicae, Fructus Schisandrae Chinensis get the meaning of SISHEN WAN, and the kidney warming warms up spleen, relieving diarrhea with astringents; Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae replenishing QI to invigorate the spleen, the gas strengthened the spleen and stomach, taste are healthy and vigorous, and warm up the Radix Aconiti Lateralis Preparata of the intestines and stomach with warming middle-JIAO, Rhizoma Zingiberis, Fructus Evodiae coordinate, activating the spleen soil, rouses oneself middle-jiao yang, function of the spleen and stomach, and middle-jiao yang, function of the spleen and stomach is shaken multiple, rises shipping and turns, can make to rise clearly turbid falling, and gastrointestinal function recovers normally; Pericarpium Citri Reticulatae, Fructus Amomi regulating qi-flowing for strengthening spleen whet the appetite; Radix Astragali Preparata invigorating middle warmer, beneficial vigour, Wen Sanjiao, shape taste, real space between skin and muscles, granulation promoting evacuation of pus, control internal injury overstrain, diarrhea due to hypofunction of the spleen is excellent.Arillus Longan sweet in the mouth temperature, property peace, heart-spleen boosting, fills blood, strengthening the spleen and stomach, moistening five ZANG-organs, tonifying YANG QI invigorating, is apt to control deficiency of vital energy edema, diarrhea due to hypofunction of the spleen.Pseudobulbus Bletillae (Rhizoma Bletillae) hardship is sweet, cool, enter lung meridian, has the merit of tonifying the lung, hemostasis, detumescence, granulation promoting, sore, cures mainly carbuncle malignant boil and lose cellulitis, canker sores, hemorrhoidal hamorrhage dysentery.External has absorption and discharges secretions, and the protection function of recovery and enhancing body produces protecting film, controls and protect from infection, clean wound, and promotion granulation tissue is newborn, accelerates the effects such as ulcer healing.Herba Portulacae (also name longevity greens/mustard green) eliminating damp-heat, loose blood detumescence, controls hematodiarrhoea pus and blood, carbuncle malignant boil.This product contains abundant vitamin A sample material, therefore can promote that epithelial physiological function is tending towards normal, and can promote the healing of ulcer.Herba Portulacae is for escherichia coli, and dysentery bacterium, Bacillus typhi, pathogenic dermatophytes are all drawn up effect, have obvious contraction, and can promote Intestinal motility to blood vessel.Medicine-feeding is share, and has invigorating QI and blood, and the kidney warming warms up spleen, convergence ulcer, the merit of intestine-stabling and anti-diarrheal.Spleen kidney two is mended, and warming middle-JIAO residence is puckery, regulating QI intestinal stasis relieving, and energy Qinghua Shi Re Bing Pian of holding concurrently, gastrointestinal function is coordinated, and ulcerative colitis certainly can rehabilitation gradually.
Above-mentioned component science, reasonable compatibility, support mutually, has effect of warming and recuperating the spleen and kidney, intestine-stabling and anti-diarrheal, puckery, the regulating QI intestinal stasis relieving of warming middle-JIAO residence, be effective to treatment yang deficiency of spleen and stomache chronic colitis, good effect, drug safety, and obtain sufficient proof through clinical data, pertinent clinical data is as follows:
(1), the inclusion criteria of yang deficiency of spleen and stomache chronic colitis:
According to clinical symptoms, by the diagnostic criteria of yang deficiency of spleen and stomache chronic colitis, select typical yang deficiency of spleen and stomache patients with chronic colitis 120 example, wherein man 64 example, female 56 example, the age be (60.1 ± 11.5) year.
(2), the diagnostic criteria of yang deficiency of spleen and stomache chronic colitis:
1, suffer from diarrhoea: Mucous Stool and bloody purulent stool, the lighter every day 3-4 times, tens of times of severe one or diarrhoea and constipation alternately occur.
2, suffer from abdominal pain: slight patient is without stomachache or only have abdominal discomfort.Generally having slightly to moderate stomachache, is left lower quadrant or lower abdomen paroxysmal pain, relates to the rule that full abdomen has pain one awareness of defecation one to alleviate after an action of the bowels.
3, constipation: once, feces is as sheep dung sample, and very then not eating cathartic can not relieving constipation for constipation defecation on the 4-5th.
4, other symptoms: abdominal distention, become thin, weak, borborygmus, insomnia, dreaminess, the disease such as to be afraid of cold.
(3), efficacy assessment standard:
cure: clinical symptom disappearance, inspection recover normal;
effective: clinical symptoms obviously alleviates, inspection obviously changes;
take a turn for the better: clinical symptom relief, inspection slightly improve;
invalid:clinical symptom and sign does not improve.
(4), therapeutic scheme
Chinese medicine of the present invention is made granule, and 1 bag is 10g, each serving 1 bag, within 1st, takes 3 times; Or make oral liquid, often prop up 20ml, take 11 time, within 1st, take 3 times; It within 15 days, is a course for the treatment of.
(5), statistical procedures:
By above-mentioned (four) therapeutic scheme, the Chinese medicine that oral the present invention provides, added up after 6 courses for the treatment of, this invention treatment by Chinese herbs yang deficiency of spleen and stomache chronic colitis curative effect of Clinical practice is better, by the clinical observation to 120 routine yang deficiency of spleen and stomache patients with chronic colitis, cure 90 examples, effective 14 examples, take a turn for the better 10 examples, cure rate reaches 75%, and total effective rate is up to 95%, evident in efficacy, through Long-term clinical checking, have no adverse reaction.
(6), conclusion
Compatibility of the present invention is reasonable, and evident in efficacy, spleen kidney two is mended, warming middle-JIAO residence is puckery, regulating QI intestinal stasis relieving, energy Qinghua Shi Re Bing Pian of holding concurrently, makes gastrointestinal function coordinate, it is the active drug being used for the treatment of yang deficiency of spleen and stomache chronic colitis, effective percentage reaches 95%, has no side effect, stable curative effect, safe and reliable, there is actual clinical meaning.
Claims (7)
1. treat the Chinese medicine of yang deficiency of spleen and stomache chronic colitis for one kind, it is characterized in that, this Chinese medicine is by following weighing scale: Radix Codonopsis 12-18g, Radix Astragali Preparata 27-33g, Poria 12-18g, Rhizoma Atractylodis Macrocephalae 9-15g, Fructus Psoraleae 12-18g, Fructus Schisandrae Chinensis 4-8g, Semen Myristicae 4-8g, Zhu's Wu cornel 2-4g, Arillus Longan 12-18g, Rhizoma Dioscoreae 27-33g, Pseudobulbus Bletillae (Rhizoma Bletillae) 17-23g, Herba Portulacae 27-33g, Fructus Amomi 6-12g, Pericarpium Citri Reticulatae 9-15g, Rhizoma Zingiberis 4-8g and Radix Glycyrrhizae Preparata 4-8g form.
2. the Chinese medicine for the treatment of yang deficiency of spleen and stomache chronic colitis according to claim 1, it is characterized in that, this Chinese medicine is by following weighing scale: Radix Codonopsis 12g, Radix Astragali Preparata 27g, Poria 12g, Rhizoma Atractylodis Macrocephalae 9g, Fructus Psoraleae 12g, Fructus Schisandrae Chinensis 4g, Semen Myristicae 4g, Zhu's Wu cornel 2g, Arillus Longan 12g, Rhizoma Dioscoreae 27g, Pseudobulbus Bletillae (Rhizoma Bletillae) 17g, Herba Portulacae 27g, Fructus Amomi 6g, Pericarpium Citri Reticulatae 9g, Rhizoma Zingiberis 4g and Radix Glycyrrhizae Preparata 4g form.
3. the Chinese medicine for the treatment of yang deficiency of spleen and stomache chronic colitis according to claim 1, it is characterized in that, this Chinese medicine is by following weighing scale: Radix Codonopsis 15g, Radix Astragali Preparata 30g, Poria 15g, Rhizoma Atractylodis Macrocephalae 12g, Fructus Psoraleae 15g, Fructus Schisandrae Chinensis 6g, Semen Myristicae 6g, Zhu's Wu cornel 3g, Arillus Longan 15g, Rhizoma Dioscoreae 30g, Pseudobulbus Bletillae (Rhizoma Bletillae) 20g, Herba Portulacae 30g, Fructus Amomi 9g, Pericarpium Citri Reticulatae 12g, Rhizoma Zingiberis 6g and Radix Glycyrrhizae Preparata 6g form.
4. the Chinese medicine for the treatment of yang deficiency of spleen and stomache chronic colitis according to claim 1, it is characterized in that, this Chinese medicine is by following weighing scale: Radix Codonopsis 18g, Radix Astragali Preparata 33g, Poria 18g, Rhizoma Atractylodis Macrocephalae 15g, Fructus Psoraleae 18g, Fructus Schisandrae Chinensis 8g, Semen Myristicae 8g, Zhu's Wu cornel 4g, Arillus Longan 18g, Rhizoma Dioscoreae 33g, Pseudobulbus Bletillae (Rhizoma Bletillae) 23g, Herba Portulacae 33g, Fructus Amomi 12g, Pericarpium Citri Reticulatae 15g, Rhizoma Zingiberis 8g and Radix Glycyrrhizae Preparata 8g form.
5. the Chinese medicine for the treatment of yang deficiency of spleen and stomache chronic colitis according to claim 1, it is characterized in that, this Chinese medicine is by following weighing scale: Radix Codonopsis 12-15g, Radix Astragali Preparata 27-30g, Poria 12-15g, Rhizoma Atractylodis Macrocephalae 9-12g, Fructus Psoraleae 12-15g, Fructus Schisandrae Chinensis 4-6g, Semen Myristicae 4-6g, Zhu's Wu cornel 2-2.5g, Arillus Longan 12-15g, Rhizoma Dioscoreae 27-30g, Pseudobulbus Bletillae (Rhizoma Bletillae) 17-20g, Herba Portulacae 27-30g, Fructus Amomi 6-9g, Pericarpium Citri Reticulatae 9-12g, Rhizoma Zingiberis 4-6g and Radix Glycyrrhizae Preparata 4-6g form.
6. the Chinese medicine for the treatment of yang deficiency of spleen and stomache chronic colitis according to claim 1, it is characterized in that, this Chinese medicine is by following weighing scale: Radix Codonopsis 16-18g, Radix Astragali Preparata 31-33g, Poria 16-18g, Rhizoma Atractylodis Macrocephalae 13-15g, Fructus Psoraleae 16-18g, Fructus Schisandrae Chinensis 7-8g, Semen Myristicae 7-8g, Zhu's Wu cornel 3-4g, Arillus Longan 16-18g, Rhizoma Dioscoreae 31-33g, Pseudobulbus Bletillae (Rhizoma Bletillae) 21-23g, Herba Portulacae 31-33g, Fructus Amomi 10-12g, Pericarpium Citri Reticulatae 13-15g, Rhizoma Zingiberis 7-8g and Radix Glycyrrhizae Preparata 7-8g form.
7. the Chinese medicine of claim 1 or the treatment yang deficiency of spleen and stomache chronic colitis described in any one of 2-6, is characterized in that, this Chinese medicine is granule or oral liquid, or makes the one of tablet, decoction, powder, pill, powder according to a conventional method.
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| CN104352712A (en) * | 2014-10-17 | 2015-02-18 | 王刚 | Traditional Chinese medicine composition for treating chronic colitis |
| CN104367926A (en) * | 2014-11-20 | 2015-02-25 | 青岛恒波仪器有限公司 | Traditional Chinese medicine preparation for treating predawn diarrhea and preparation method thereof |
| CN105031570A (en) * | 2015-07-04 | 2015-11-11 | 青岛云天生物技术有限公司 | Traditional Chinese medicine preparation used for treating infant spleen-kidney-yang deficiency diarrhea |
| CN105169328A (en) * | 2015-09-30 | 2015-12-23 | 王鹏飞 | Traditional Chinese medicine preparation for treating chronic colitis |
| CN107582913A (en) * | 2017-10-25 | 2018-01-16 | 周安德 | A kind of Chinese medicine for treating chronic colitis |
| CN108404033A (en) * | 2018-05-17 | 2018-08-17 | 杜建伟 | A kind of Chinese medicine of tcm internal medicine treatment enteritis |
| CN115397451A (en) * | 2020-04-03 | 2022-11-25 | (株)美迪合伙来音 | Oral pharmaceutical composition comprising arillus longan combined crude drug composition for treating or improving inflammatory diseases, and its application |
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| CN101085331A (en) * | 2007-06-16 | 2007-12-12 | 房立海 | Capsule for treating enteritis |
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