CN103520625B - 治疗肝肾不和证型痞满病的中药 - Google Patents
治疗肝肾不和证型痞满病的中药 Download PDFInfo
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Abstract
本发明公开了一种治疗肝肾不和证型痞满病的中药，其特征在于由以下重量配比的药材制成的：柴胡18份、炒枳实20份、姜半夏10份、人参10份、白术20份、茯苓30份、大黄10份、厚朴10份、九节菖蒲10份、砂仁10份、代赭石15份（单放）、蜜旋覆花10份（单放）干姜10份、甘草6份、黄连10份。本发明选择了合适的药材及其配比，各药材之间相互配合，协同作用，达到辩症施治，对症用药的效果，所制成的中药能有效治疗肝肾不和证型痞满病，4年来，通过对105名肝肾不和证型痞满患者的使用表明，总有效率达90%，愈后不再复发。
Description
技术领域
本发明涉及一种中药，特别是一种用于治疗肝肾不和证型痞满病的中药。
背景技术
痞满是临床中常见的一种症状，它是指以自觉心下痞塞，胸膈胀满，触之无形，按之柔软，压之无痛为主要症状的病证，一般指胃脘部或胃脘以下部位满闷痞塞不通而言。肝肾不和而致的痞满是常见的痞满病之一。目前，治疗肝胃不和证型痞满病的中药有许多种，但大多数治疗效果不尽人意，治愈率较低。
本发明所涉及的药材的研究现状如下：
柴胡：【来源】为伞形科植物柴胡Bupleurum chinense DC.或狭叶柴胡Bupleurum scorzonerifolium Willd.的干燥根。【性味】苦、微寒。【归经】入肝、胆经。【功能主治】具有透表泄热、疏肝解郁、升举阳气之功效，《本草纲目》称其有治阳热下陷、平肝胆三焦包络相火及头痛、眩晕、妇人热入血室、经水不调等症，柴胡作为临床常用中药，临床常配伍应用，总结其有疏郁、升清、散邪、清热之功。
炒枳实【来源】 本品为芸香科植物酸橙Citrus aurantium L. 及其栽培变种或甜橙Citrus sinensis Osbeck 的干燥幼果。【性味】 苦、辛、酸，温。
【归经】 归脾、胃经。【功能主治】破气消积，化痰散痞。用于积滞内停，痞满胀痛，泻痢后重，大便不通，痰滞气阻胸痹，结胸；胃下垂，脱肛，子宫脱垂。
姜半夏【来源】本品为天南星科植物半夏Pinellia ternata （Thunb.） Breit. 的干燥块茎。炮制方法：取拣净的半夏，浸泡至口尝稍有麻辣感后，另取生姜切片煎汤，加白矾与半夏共煮透，取出，晾至六成干，闷润后切片，晾干。【性味】辛、温；有毒。【归经】归脾、胃、肺经。【功能主治】降逆止呕。用于呕吐反胃，胸脘痞闷，梅核气。
人参【来源】 本品为五加科植物人参Panax ginseng C. A. Mey.的干燥根。【性味】 甘、微苦，平。【归经】 归脾、肺、心经。【功能主治】 大补元气，复脉固脱，补脾益肺，生津，安神。用于体虚欲脱，肢冷脉微，脾虚食少，肺虚喘咳，津伤口渴，内热消渴，久病虚羸，惊悸失眠，阳痿宫冷；心力衰竭，心原性休克。
白术：为菊科植物白术Atractylodes macrocephala Koidz.的干燥根茎。性味归经：性味苦、甘，温；归脾、胃经。功能主治：健脾益气，燥湿利水，止汗，安胎。用于治脾气虚弱，食少便溏，痰饮水肿，表虚自汗，胎动不安。
茯苓：为多孔菌科真菌茯苓 Poria cocos （Schw.） Wolf 的干燥菌核。性味归经：性味甘、淡，平；归心、脾、肾经。功能主治：利水渗湿，健脾和胃，宁心安神。用于治小便不利；水肿胀满；痰饮咳逆；呕吐；脾虚食少；泄泻；心悸不安；失眠健忘；遗精白浊。
大黄【来源】 本品为蓼科植物掌叶大黄Rheum palmatum L。、 唐古特大黄Rheum tanguticum Maxim。 ex Balf。或药用大黄Rheum officinale Baill。的干燥根及根茎。【性味】 苦，寒。【归经】 归脾、胃、大肠、肝、心包经。【功能主治】 泻热通肠，凉血解毒，逐瘀通经。用于实热便秘，积滞腹痛，泻痢不爽，湿热黄疸，血热吐衄，目赤，咽肿，肠痈腹痛，痈肿疔疮，瘀血经闭，跌打损伤，外治水火烫伤；上消化道出血。
厚朴【来源】 本品为木兰科植物厚朴Magnolia officinalis Rehd. et Wils.或凹叶厚朴Magnolia officinalis Rehd. et Wils. var. biloba Rehd. et Wils.的干燥干皮、根皮及枝皮。【性味】 苦、辛，温。【归经】 归脾、胃、肺、大肠经。【功能主治】 燥湿消痰，下气除满。用于湿滞伤中，脘痞吐泻，食积气滞，腹胀便秘，痰饮喘咳。
九节菖蒲【来源】为毛茛科植物阿尔泰银莲花的根茎。【性味】辛；温。【归经】心；肝；脾经【功能主治】化痰开窍；安神；宣湿醒脾；解毒。主热病神昏，癫痫，气闭耳聋，多梦健忘，胸闷腹胀，食欲不振，；风湿痹痛，痈疽，疥癣。
砂仁【来源】 本品为姜科植物阳春砂Amomum villosum Lour. 、绿壳砂Amomum villosum Lour. var. xanthioides T. L. Wu et Senjen 或海南砂Amomum longiligulare T. L. Wu 的干燥成熟果实。【性味】 辛，温。【归经】 归脾、胃、肾经。【功能主治】 化湿开胃，温脾止泻，理气安胎。用于湿浊中阻，脘痞不饥，脾胃虚寒，呕吐泄泻，妊娠恶阻，胎动不安。
代赭石【别名】：代赭石，赤赭石。【来源】 为氧化物类矿物赤铁矿的矿石。【性味】 苦甘，平。【归经】 入肝、胃、心胞经。【功能主治】 平肝镇逆，凉血止血。治噫气呕逆，噎膈反胃，哮喘，惊痫，吐血，鼻衄，肠风，痔瘘，崩漏带下。
蜜旋覆花【来源】 本品为菊科植物旋覆花Inula japonica Thunb.或欧亚旋覆花Inula britannica L.的干燥头状花序。蜜旋覆花的炮制：取净旋覆花，照蜜炙法炒至不粘手。【性味】 苦，辛、咸，微温。【归经】 归肺、脾、胃、大肠经。【功能主治】 降气，消痰，行水，止呕。用于风寒咳嗽，痰饮蓄结，胸膈痞满,喘咳痰多，呕吐噫气，心下痞硬。
干姜【来源】 本品为姜科植物姜Zingiber officinale Rosc.的干燥根茎。【性味】 辛、热。【归经】 归脾、胃、肾、心、肺经。【功能主治】 干姜温中散寒，回阳通脉，燥湿消痰。用于脘腹冷痛，呕吐泄泻，肢冷脉微，痰饮喘咳。
甘草：为豆科植物甘草 Glycyrrhiza uralensis Fisch 的干燥根。性味归经：性味甘，平；归肺、脾、胃经。功能主治：具补脾益气、润肺止咳、缓急止痛、缓和药性之功效。用于脾胃虚弱，倦怠乏力，心悸气短，咳嗽痰多，脘腹、四肢挛急疼痛。
黄连：为毛茛科植物黄连、三角叶黄连、峨嵋野连或云南黄连的根茎。性味归经：性味苦，寒；归心、胃、肝、大肠经。功能主治：清热燥湿，泻火解毒。用于湿热痞满，呕吐吞酸，泻痢，黄疸，高热神昏，心火亢盛，心烦不寐，血热吐衄，目赤，牙痛，消渴，湿疮，痈肿疔疮。
发明内容
本发明旨在提供一种治疗肝肾不和证型痞满病的中药，通过选择合适的药材及其配比，达到安全有效治愈肝肾不和证型痞满病的目的。
为达到上述目的，本发明采用以下技术方案：
一种治疗肝肾不和证型痞满病的中药，其特征在于由以下重量配比的药材制成的：
柴胡18份、炒枳实20份、姜半夏10份、人参10份、白术20份、茯苓30份、大黄10份、厚朴10份、九节菖蒲10份、砂仁10份、代赭石15份（单放）、蜜旋覆花10份（单放）干姜10份、甘草6份、黄连10份。
中医认为：肝主疏泄，肾主藏精。肝肾不和证型痞满病是因肝肾不和而导致脾胃失调，脾胃损伤，升降失司，胃气壅塞，从而引起痞满。本发明选择了合适的药材及其配比，各药材之间相互配合，协同作用，达到辩症施治，对症用药的效果，所制成的中药能有效治疗肝肾不和证型痞满病，4年来，通过对105名肝肾不和证型痞满患者的使用表明，总有效率达90%，愈后不再复发。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2009年5月-2013年5月间共收集了105例治疗肝肾不和证型痞满病门诊患者，其中，男56例，女49例，年龄41-57岁，病情2个月-2年。随机分为：治疗组60例，对照组45例。两组年龄等资料无显著性差异，具有可比性。
2、试验方法
2.1对照组口服爽速安胃疡安胶囊，按照说明书服用。疗程15天。
2.2治疗组口服本发明按照具体实施例1制得的胶囊，早、中、晚各一次。疗程15天。
3、疗效标准及治疗结果
3.1疗效标准：
痊愈：肝肾不和证型痞满病的临床症状全部消失。好转：肝肾不和证型痞满病的临床症状减轻，病情得到控制。无效：临床症状无明显好转或加重。
3.2治疗统计结果见表1。
表1 两组疗效比较
| 组别 | n | 痊愈 | 好转 | 无效 | 总有效率（%） |
| 治疗组 | 60 | 14 | 40 | 6 | 90% |
| 对照组 | 45 | 4 | 19 | 22 | 51.1% |
由此可见，采用本发明的组方制得的药物能够安全治疗肝肾不和证型痞满病。
具体实施方式
为了更好地理解与实施本发明，下面结合具体实施例进一步说明本发明。
具体实施例1
称取柴胡18克、炒枳实20克、姜半夏10克、人参10克、白术20克、茯苓30克、大黄10克、厚朴10克、九节菖蒲10克、砂仁10克、干姜10克、甘草6克、黄连10克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，将代赭石15克、蜜旋覆花10克粉磨成粉沫状，与上述干燥物混合均匀，装入胶囊壳，即得符合正常成人1天用量的胶囊剂。
用于治疗肝肾不和证型痞满病。口服，每日分早、中、晚三次服用。
具体实施例2
称取柴胡18克、炒枳实20克、姜半夏10克、人参10克、白术20克、茯苓30克、大黄10克、厚朴10克、九节菖蒲10克、砂仁10克、干姜10克、甘草6克、黄连10克，加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，将代赭石15克、蜜旋覆花10克粉磨成粉沫状，与上述干燥物混合均匀，包装，即得符合正常成人1天用量的散剂。
用于治疗肝肾不和证型痞满病。口服，每日分早、中、晚三次服用。
具体实施例3
称取柴胡18克、炒枳实20克、姜半夏10克、人参10克、白术20克、茯苓30克、大黄10克、厚朴10克、九节菖蒲10克、砂仁10克、干姜10克、甘草6克、黄连10克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，将代赭石15克、蜜旋覆花10克粉磨成粉沫状，与上述干燥物混合均匀，按照本领域常规工艺制粒，包装，即得符合正常成人1天用量的颗粒剂。
用于治疗肝肾不和证型痞满病。口服，每日分早、中、晚三次服用。
Claims (1)
1.一种治疗肝肾不和证型痞满病的中药，其特征在于由以下重量配比的药材制成的：
柴胡18份、炒枳实20份、姜半夏10份、人参10份、白术20份、茯苓30份、大黄10份、厚朴10份、九节菖蒲10份、砂仁10份、代赭石15份、蜜旋覆花10份、干姜10份、甘草6份、黄连10份；其中代赭石以及蜜旋覆花单放。
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