CN103520325A - 一种治疗酒精型脂肪肝的中药 - Google Patents
一种治疗酒精型脂肪肝的中药 Download PDFInfo
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Abstract
本发明涉及一种治疗酒精型脂肪肝的中药，由以下重量配比的药材制备而成：大叶铁包金9份、牛尾独活12份、四叶葎14份、大叶酸藤子10份、粗榧子12份、杧果12份、大鱼鳅串10份、刀口药8份、拐枣七10份、大籽蒿14份、糙叶水苎麻12份、楮树根14份、翅果唐松草10份、云木香10份、横经席12份、土千年健8份。临床实验证明，本发明能够安全有效治疗酒精型脂肪肝。
Description
技术领域
本发明涉及一种中药，具体涉及一种治疗酒精型脂肪肝的中药。
背景技术
酒精性脂肪肝是由于长期大量饮酒导致的肝脏疾病。是酒精性肝病中的一个分型临床症状为非特异性，可无症状，或有右上腹胀痛、食欲不振、乏力、体重减轻等。
对于酒精型脂肪肝的治疗，目前主要的措施是戒酒和营养支持，尚缺少公认安全有效的治疗药物。
本发明中药所涉及药材的研究现状如下：
大叶铁包金【来源】鼠李科勾儿茶属植物牛鼻拳Berchemia giraldiana Schneid.，以根入药。四季可采，晒干备用。【功能主治】祛风利湿，止咳化痰。用于风湿关节痛，肺结核，肝炎。
牛尾独活【来源】伞形科牛尾独活属植物牛尾独活Heracleum vicinum Boiss.的根。秋季采收，去茎叶和细根，洗净晒干。【功能主治】祛风除湿，通痹止痛。用于风寒湿痹，腰膝疼痛，少阴伏风头痛。
四叶葎【来源】茜草科拉拉藤属植物四叶葎Galium bungei Stend.以全草入药。夏秋采集，鲜用或晒干。【功能主治】清热解毒，利尿，止血，消食。用于痢疾，尿路感染，小儿疳积，白带，咳血；外用治蛇头疔。
大叶酸藤子【来源】为紫金牛科植物大叶酸藤子的果实。秋季采收成熟的果实，除去杂质，晒干。【功能主治】驱虫。主蛔虫病。
粗榧子【来源】粗榧科粗榧属植物三尖杉Cephalotaxus fortunei Hook. f.和中国粗榧C. sinensis （Rehd. EtWils.） Li的种子。秋季采摘，晒干。【功能主治】驱虫，消积。用于蛔虫病，钩虫病，食积。
杧果【来源】漆树科杧果属植物杧果Mangifera indica L.，以果、果核、叶入药。全年采叶，夏秋采果，鲜用或晒干。【功能主治】果、果核：止咳，健胃，行气。用于咳嗽，食欲不振，睾丸炎，坏血病。叶：止痒。外用治湿疹瘙痒。
大鱼鳅串【来源】为菊科植物秋分草的全草。夏、秋季采收，洗净，晒干。【功能主治】清湿热；利消肿。主湿热带下；急慢性肝炎；肝硬化腹水。
刀口药【来源】为菊科植物三花兔耳风的叶。夏、秋采叶，晒干或研粉备用。【功能主治】止血，生肌，收口。治刀伤出血，研末撒伤处。
拐枣七【来源】罂粟科荷青花属植物荷青花，以根入药。夏秋采挖，阴干。【功能主治】祛风湿，舒筋活络，散瘀消肿，止血，止痛。用于风湿性关节炎，跌打损伤。
大籽蒿【来源】菊科大籽蒿Artemisia sieversiana Willd.，以花蕾入药。【功能主治】消炎止痛。痈肿疔毒。
糙叶水苎麻【来源】为荨麻科植物糙叶水苎麻的茎叶或根。秋、冬季采收，鲜用或晒干。【功能主治】祛风除湿；解毒；疗疮。主风湿痹痛；疮毒；烧烫伤；疟疾。
楮树根【来源】为桑科植物构树的嫩根或根皮。9～10月采。【功能主治】清热，凉血，利湿，祛痰。治咳嗽吐血，水肿，血崩，跌打损伤。
翅果唐松草【来源】为毛良种植物翅果唐松草的全草或根及根茎。秋季采挖根及根茎，去泥砂，晒干；夏季采全草，晒干。【功能主治】清热解毒。治肺热咳嗽，咽峡炎。
云木香【来源】为菊科云木香属植物云木香Aucklandia lappa Decne.的根。秋季至第二年春初采挖，除去茎叶泥土，切成短段，粗大者纵剖2～4块，晒干。【功能主治】行气止痛，温中和胃。用于胸腹胀痛，呕吐，泄泻，痢疾里急后重。
横经席【来源】藤黄科胡桐属植物薄叶胡桐Calophyllum membranaceum Gardn. etChamp.，以根、叶入药。全年或秋冬采，鲜用或晒干。【功能主治】祛风湿，壮筋骨，活血止痛。根、叶：用于风湿关节痛，腰腿痛，跌打损伤，黄疸型肝炎，月经不调，痛经。叶：外用治外伤出血。
土千年健【来源】杜鹃花科乌饭树属植物毛叶乌饭树Vaccinium fragile Franch.，以根及叶入药。全年可采，切片晒干或鲜用。【功能主治】舒筋活血，消炎止痛。用于风湿性关节炎，跌打损伤，腮腺炎，急性结膜炎，痢疾，胃痛。
发明内容
本发明旨在提供一种治疗酒精型脂肪肝的中药，通过选择合适的药材及其配比，达到安全有效治愈酒精型脂肪肝的目的。
为了达到上述目的，本发明采用以下技术方案：
一种治疗酒精型脂肪肝的中药，其特征在于，由以下重量配比的药材制备而成：大叶铁包金9份、牛尾独活12份、四叶葎14份、大叶酸藤子10份、粗榧子12份、杧果12份、大鱼鳅串10份、刀口药8份、拐枣七10份、大籽蒿14份、糙叶水苎麻12份、楮树根14份、翅果唐松草10份、云木香10份、横经席12份、土千年健8份。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2009年12月-2011年11月间共收集127例酒精型脂肪肝的门诊患者，年龄23-51岁，病程1-3年。随机分为：治疗组92例，空白组35例。两组年龄、病情等资料无显著性差异，具有可比性。
2、试验方法
2.1治疗组口服本发明按照具体实施例1制得的胶囊，早晚各一次。疗程15天。
2.2空白组口服安慰剂胶囊，早晚各一次。疗程15天。
3、疗效标准与治疗结果
3.1疗效标准
痊愈：临床症状全部消失，试验室检查正常，观察三个月未见反复。好转：临床症状减轻，病情得到控制，实验室检查改善或正常。无效：临床症状无明显好转或加重。
3.2治疗统计结果见表1。
表1 两组疗效比较
| 组别 | n | 痊愈 | 好转 | 无效 | 总有效率(%) | 不良反应例 | 不良反应例 |
| 治疗组 | 92 | 23（25%） | 57（62%) | 12(13%) | 87% | 0 | 0 |
| 空白组 | 35 | 0 | 6(17.1%) | 29（82.9%） | 17.1% | 0 | 0 |
可见，本发明制得的药物能够安全有效治疗酒精型脂肪肝。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
具体实施例1
称取：大叶铁包金9克、牛尾独活12克、四叶葎14克、大叶酸藤子10克、粗榧子12克、杧果12克、大鱼鳅串10克、刀口药8克、拐枣七10克、大籽蒿14克、糙叶水苎麻12克、楮树根14克、翅果唐松草10克、云木香10克、横经席12克、土千年健8克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，装入胶囊壳，即得符合正常成人1天用量的胶囊剂。
用于治疗酒精型脂肪肝。口服，每日分早晚两次服用。
具体实施例2
称取：大叶铁包金9克、牛尾独活12克、四叶葎14克、大叶酸藤子10克、粗榧子12克、杧果12克、大鱼鳅串10克、刀口药8克、拐枣七10克、大籽蒿14克、糙叶水苎麻12克、楮树根14克、翅果唐松草10克、云木香10克、横经席12克、土千年健8克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，粉碎，即得符合正常成人1天用量的散剂。
用于治疗酒精型脂肪肝。口服，每日分早晚两次服用。
具体实施例3
称取：大叶铁包金9克、牛尾独活12克、四叶葎14克、大叶酸藤子10克、粗榧子12克、杧果12克、大鱼鳅串10克、刀口药8克、拐枣七10克、大籽蒿14克、糙叶水苎麻12克、楮树根14克、翅果唐松草10克、云木香10克、横经席12克、土千年健8克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，再加入适量糊精和矫味剂，按照本领域常规工艺制粒，包装，即可制得符合正常成人1天用量的颗粒剂。
用于治疗酒精型脂肪肝。口服，每日分早晚两次服用。
Claims (1)
1.一种治疗酒精型脂肪肝的中药，其特征在于，由以下重量配比的药材制备而成：大叶铁包金9份、牛尾独活12份、四叶葎14份、大叶酸藤子10份、粗榧子12份、杧果12份、大鱼鳅串10份、刀口药8份、拐枣七10份、大籽蒿14份、糙叶水苎麻12份、楮树根14份、翅果唐松草10份、云木香10份、横经席12份、土千年健8份。
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| CN104352411A (zh) * | 2014-11-14 | 2015-02-18 | 陈爱华 | 一种喷雾型止汗剂及其制备方法 |
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| Title |
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| 赵昱: "天然药物防治非酒精性和酒精性脂肪肝的研究进展", 《国际药学研究杂志》 * |
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| CN104352411A (zh) * | 2014-11-14 | 2015-02-18 | 陈爱华 | 一种喷雾型止汗剂及其制备方法 |
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