CN103505695B - Traditional Chinese medicine combination for treating prostatitis and benign prostate hyperplasia and preparation method thereof - Google Patents
Traditional Chinese medicine combination for treating prostatitis and benign prostate hyperplasia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine combination for treating prostatitis and benign prostate hyperplasia and a preparation method thereof, and belongs to the technical field of medicine preparation. The traditional Chinese medicine combination is characterized in that a raw material formula comprises 1500g of cowherb seed, 1500g of adix cyathulae, 1000g of smilax glabra, 500g of rhizoma bolbostemmae, 50g of radix curcuma, 50g of rhizoma cyperi, 500g of cornus officinalis, 500g of herba epimedii, 100g of olibanum, 100g of myrrh, 10g of borneol, 2650g of vaseline, 200g of wool fat, 100g of propanediol, 50g of azone and 3g of ethylparaben. The preparation method of the traditional Chinese medicine combination comprises the following steps: extracting the raw materials with part of alcohol, then extracting with part of water, crushing and mixing so as to obtain paste dosage form for external application. Experiments prove that the traditional Chinese medicine combination has very good treatment effect on the prostatitis and the benign prostate hyperplasia.
Description
One, technical field
The present invention relates to a kind of Chinese medicine for the treatment of prostatosis, specifically a kind ofly treat Chinese medicine composition of prostatitis and prostatic hyperplasia and preparation method thereof, belong to medicine manufacture technology field, comprise preparation method.
Two, background technology
Prostatitis and prostatic hyperplasia are the frequently-occurring diseases of male, are also the commonly encountered diseases of Urology Surgery, and it is thin, dripping not to the utmost etc. that the clinical manifestation of this disease is mainly frequent micturition, urgent micturition, dysurea, acraturesis, urine line.Although the state of an illness is not very serious, very large on the physical and mental health impact of patient, often with neural and mental symptom.Along with growth in the living standard, the change of dietary structure, prostatosis sickness rate has the trend day by day increased, and carries out preventing and controlling, and reducing prostatosis sickness rate, is very important to improving the quality of living.
At present, the method for the treatment of prostatitis and prostatic hyperplasia has oral drugs, antibiotic therapy, acupuncture and moxibustion therapy, naturopathy, injection for curing etc., due to the barrier action of prostate adipose membrane, most of antibacterials are difficult to enter in prostate and reach effective Mlc, only has fat-soluble high alkalescent medicine, be combined few with plasma protein, the medicine that the degree of dissociation is high, the medicine good to prostate adipose membrane dispersivity just likely plays good curative effect.Because many antibiotic are difficult to through prostatic lipid envelope, therefore, some doctors take directly antimicrobial drug to be injected in prostate to treat prostatitis, obtain certain curative effect, but injection for curing must be operated by Urology Surgery doctor, and technical requirement is higher, and patient suffering is large.Acupuncture and moxibustion therapy needs special acupuncturist to implement, and this easily produces stimulation to skin sensitivity person, and naturopathy is conducive to the dissipation of inflammation, but cannot reach the effect that healing do not recur,
Three, summary of the invention
The object of the invention is to solve existing treatment prostatitis and prostatic hyperplasia that to there is oral drugs side effect large, targeting is indefinite, and drug effect is not concentrated, easily recurrence after curing, injection for curing technical requirement is higher, and patient suffering is large, thus provides a kind of new therapeutic scheme.
For achieving the above object, the present invention realizes by following technical scheme:
Treat a Chinese medicine composition for prostatitis and prostatic hyperplasia, it is the medicament be made up of the raw material of following weight number ratio:
Semen Vaccariae 1500g, Radix Cyathulae 1500g, Rhizoma Smilacis Glabrae 1000g, Rhizoma Bolbostematis 500g,
Rhizoma Curcumae Longae 50g, Rhizoma Cyperi 50g, Fructus Corni 500g, Herba Epimedii 500g,
Olibanum 100g, Myrrha 100g, Borneolum Syntheticum 10g, vaseline 2650g
Lanoline 200g, propylene glycol 100g, azone 50g, ethyl hydroxybenzoate 3g.
Externally applied plaster paste formulation type with above-mentioned raw material weight number than the dosage form manufactured.
Treat a preparation method for the Chinese medicine composition of prostatitis and prostatic hyperplasia, its preparation method and step are:
A. medical material is made rear for subsequent use only;
B. Borneolum Syntheticum, ethyl hydroxybenzoate add appropriate amount of ethanol and dissolve for subsequent use;
C. Olibanum, Myrrha are freezing, pulverize, and crossing 80-100 order, to make into fine powder for subsequent use;
D. Rhizoma Curcumae Longae, Rhizoma Cyperi 50 DEG C of-60 DEG C of cold drying, pulverize, and after 100-120 order makes into fine powder excessively, add c item traditional Chinese medicine fine powder, stir, mixing, and fine powder is for subsequent use;
E. Semen Vaccariae, Radix Cyathulae, Rhizoma Smilacis Glabrae, Rhizoma Bolbostematis, Fructus Corni, Herba Epimedii add 8 times, 6 times weight water, and decoct 2 times, decocting time is respectively 2 hours, 1 hour, collecting decoction, filter, filtrate reduced in volume is to relative density 1.25-1.30,60 DEG C of clear paste surveyed, for subsequent use;
F. after vaseline, lanoline heating and melting, under continuous equidirectional stirring, slowly add clear paste and propylene glycol, azone under e item, continue to stir, mixing, when temperature is down to 45 ~ 50 DEG C, then to add under d item solution under fine powder and b item respectively, stirs, mixing, makes 1000 subsides, often pastes 5g;
G. subpackage, packaging,
60co irradiation dose 5kGy sterilizes, and puts in storage for subsequent use.
The feature that the present invention is compared with prior art had is: (1) transdermal drug delivery system can avoid the first pass effect of liver and medicine in gastrointestinal deactivation, and the absorption of medicine, by the impact of gastrointestinal factors, reduces the individual variation of medication.(2) maintain constant effective blood drug concentration or physiological effect, the blood drug level peak valley phenomenon avoiding oral administration to cause, reduce toxicity.(3) reduce administration number of times, improve therapeutic efficacy, extend action time, avoid multiple dose administration, make most patient be easy to accept.(4) easy to use, patient can independently medication, also can cancel medication at any time.Medicine material component is few, and cream method processed is simple, and toxic and side effects is little.
Experiment proves the present invention: cure rate is high, and relapse rate is low.
Name of product of the present invention is " prostatitis of an established trade mark of a specified duration pastes ", " beautiful happy subsides of an established trade mark of a specified duration ".
Drug usage consumption of the present invention, external use plaster, often pastes net content 5g, each 1 subsides/day.
Four, detailed description of the invention
Now in conjunction with specific embodiments the present invention is described in further details:
Treat a Chinese medicine composition for prostatitis and prostatic hyperplasia, it is the medicament be made up of the raw material of following weight grams ratio:
Semen Vaccariae 1500g, Radix Cyathulae 1500g, Rhizoma Smilacis Glabrae 1000g, Rhizoma Bolbostematis 500g, Rhizoma Curcumae Longae 50g, Rhizoma Cyperi 50g, Fructus Corni 500g, Herba Epimedii 500g, Olibanum 100g, Myrrha 100g, Borneolum Syntheticum 10g, vaseline 2650g, lanoline 200g, propylene glycol 100g, azone 50g, ethyl hydroxybenzoate 3g.
Externally applied plaster paste formulation type by above-mentioned raw material weight grams than the dosage form manufactured.
Treat a preparation method for the Chinese medicine composition paste formulation type of prostatitis and prostatic hyperplasia, its preparation method and step are:
A, medical material are made rear for subsequent use only;
B. Borneolum Syntheticum, ethyl hydroxybenzoate add appropriate amount of ethanol and dissolve for subsequent use;
C. Olibanum, Myrrha are freezing, pulverize, and crossing 80 orders, to make into fine powder for subsequent use;
D. Rhizoma Curcumae Longae, Rhizoma Cyperi 50 DEG C of-55 DEG C of cold drying, pulverize, and after 100 orders make into fine powder excessively, add c item traditional Chinese medicine fine powder, stir, mixing, and fine powder is for subsequent use;
E. Semen Vaccariae, Radix Cyathulae, Rhizoma Smilacis Glabrae, Rhizoma Bolbostematis, Fructus Corni, Herba Epimedii add 8 times, 6 times weight water, and decoct 2 times, decocting time is respectively 2 hours, 1 hour, collecting decoction, filter, filtrate reduced in volume is to relative density 1.25,60 DEG C of clear paste surveyed, for subsequent use;
F. after vaseline, lanoline heating and melting, under continuous equidirectional stirring, slowly add clear paste and propylene glycol, azone under e item, continue to stir, mixing, when temperature is down to 45 ~ 46 DEG C, then to add under d item solution under fine powder and b item respectively, stirs, mixing, makes 1000 subsides, often pastes 5g;
G. subpackage, packaging,
60co irradiation dose 5kGy sterilizes, and puts in storage for subsequent use.
The health-care effect that the present invention has is: blood circulation promoting and blood stasis dispelling, and eliminating stagnation is logical closes.
Prostatitis, prostatic hyperplasia belong to motherland's medical science " gallery is closed " category.Mainly with damp and hot, stasis blocking, suffer from a deficiency of the kidney as its pathogeny, when with blood circulation promoting and blood stasis dispelling, eliminating stagnation is logical closes as the rule for the treatment of.
Select Semen Vaccariae dissipating blood stasis for subsidence of swelling in side, inducing diuresis for treating stranguria syndrome is monarch drug.Modern pharmacological research shows: Semen Vaccariae has antiearly pregnancy, regulation of physiological functions, affects internal metabolism etc.
Be aided with Radix Cyathulae removing blood stasis dredging collateral, inducing diuresis for treating stranguria syndrome; Rhizoma Smilacis Glabrae heat-clearing and toxic substances removing, dampness removing is treating stranguria; Rhizoma Bolbostematis eliminating stagnation, detumescence, removing toxic substances; Rhizoma Curcumae Longae, Rhizoma Cyperi promoting QI circulation for relieving depression, removing obstruction in the collateral to relieve pain is to strengthen monarch drug promoting blood circulation to remove blood stasis, and the power of inducing diuresis for treating stranguria syndrome is ministerial drug altogether.Radix Achyranthis Bidentatae: eliminating blood stasis and inducing menstruation, invigorating the liver and kidney, bone and muscle strengthening, inducing diuresis for treating stranguria syndrome, priming is descending.Modern pharmacological research shows: antiinflammatory, analgesic activity.Ecdysterone can improve liver function, reduces plasma cholesterol effect, the effect that Radix Achyranthis Bidentatae decocting liquid or alcohol extract have mild diuretic and shorten the Bombyxmori Linnaeus length of time.Rhizoma Smilacis Glabrae: removing toxic substances, dehumidifying, easing joint movement.Modern pharmacological research shows: antitumor action.Rhizoma Bolbostematis: removing toxic substances, eliminating stagnation, detumescence.Modern pharmacological research shows: have antitumor action, antivirus action, haemolysis.Rhizoma Curcumae Longae: removing blood stasis circulation of qi promoting, inducing menstruation to relieve menalgia.Modern pharmacological research shows: have effect for reducing blood fat, antitumor action, antiinflammatory action, resisting pathogenic microbes effect.Rhizoma Cyperi: resolving depression of regulating the flow of vital energy, menstruction regulating and pain relieving.Modern pharmacological research shows: have analgesia, antibacterial action.Olibanum, Myrrha blood-activating and qi-promoting, reducing swelling and alleviating pain; Fructus Corni, Herba Epimedii invigrating kidney, strengthening the tendons and bones is adjuvant drug.Olibanum: analgesic therapy of invigorating blood circulation, detumescence and promoting granulation.Modern pharmacological research shows: this product has more significant analgesic activity.Headed by Olibanum, the uterus ball of taste medicine antibacterially have stronger bacteriostasis than multiple, and effectively can kill infusorian.Myrrha: dissipating blood stasis analgesic therapy, detumescence and promoting granulation.Modern pharmacological research shows: antibacterial, antiinflammatory, analgesic effect etc.Fructus Corni: liver and kidney tonifying, arresting collape syndrome by astringents.Modern pharmacological research shows: have anti-inflammatory, antibacterial effect, Fructus Corni water decoction xylol, Ovum Gallus domesticus album, acetic acid etc. cause inflammatory exudation and tissue edema that scorching thing causes and granulation tissue hyperplasia all has obvious inhibitory action, PGE content in swollen tissue is had no significant effect, ascorbic content in adult rat adrenal tissue can be reduced, alleviate adrenal cells infringement.Point out its Anti-inflammatory Mechanism relevant with enhancing Pituitary Adrenalcortical function, to PGE synthesis release without obvious inhibitory action.Fructus Corni has stronger inhibitory action to staphylococcus epidermidis; Also inhibitory action is had to enterococcus, staphylococcus aureus, dysentery bacterium etc.Herba Epimedii: kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.Modern pharmacological research shows: have Andrin-like action, the effect to cardiovascular system: have effects such as increasing coronary flow, anoxia enduring, Ischemic myocardium, blood pressure lowering.On the impact of immunologic function, in addition, the effects such as defying age, resisting fatigue, antiviral are still had.Borneolum Syntheticum clearing away heat to alleviate pain, and fragrance is walked to alter, in the current Zhu Jinger side of drawing, all medicines are returned through for making medicine.All medicines tie in above, play blood circulation promoting and blood stasis dispelling altogether, the logical effect of closing of eliminating stagnation.
Pharmacodynamics test shows: " prostatitis of an established trade mark of a specified duration pastes " is through the nontoxic level in the true border of rat acute percutaneous toxicity test; Repeatedly Skin Irritation Test belongs to nonirritant; Skin anaphylactic test belongs to without sensitization; Anti-inflammation test, analgesic test, microcirculation test have antiinflammatory, improve the microcirculatory effect of Mice Auricle and certain analgesic effect.
Drug effect survey report:
The present invention's effectiveness of row adenitis and prostatic hyperplasia and low paying property of thorn of low toxicity is before the treatment proved below by way of zoopery.
(1) rat acute percutaneous toxicity test
1, tested material: " beautiful happy subsides of an established trade mark of a specified duration " are sepia patch, take tested material ointment 50g adding distil water modulation finished product 50% pastel for subsequent use.
2, laboratory animal: provide SD rat 20 by Traditional Chinese Medicine Research Institute, Shanxi Province Experimental Animal Center, male and female half and half, body weight 180-220g, primary animal (dynamic No. 08-25th, the word of doctor).
3, animal housing's environment: temperature 22-25 DEG C, relative humidity: 45-55%.The Animal House quality certification number: dynamic No. 08-37th, the word of doctor.
4, test method: test first 24 hours, in back part of animal spinal column both sides unhairing, unhairing scope is about body surface area 10%.By the dosage (coating amount 1.0g/100g.bw) of 5000mg/kg.bw, examination Mus unhairing position is applied and fixed, after 24 hours, the residual tested material of warm water removing, Continuous Observation 7 days.
5, result of the test: have no examination Mus whole body ANOMALOUS VARIATIONS in the observation period, also have no dead, is coated with the reactions such as tested material local has no red and swollen, festers, inflammation, necrosis.The results are shown in Table 1
Table 1: " prostatitis of an established trade mark of a specified duration pastes " is to rat acute dermal toxicity result of the test
Upper table display, " prostatitis of an established trade mark of a specified duration pastes " is to white mouse percutaneous LD female, great and mighty or powerful
50all be greater than 5000mg/kg.bw.
6, evaluate: according to acute dermal toxicity grade scale in DB61-267-1998 " health product Toxicological evaluation program and test method ", " prostatitis of an established trade mark of a specified duration pastes " nontoxic level in the true border of rat acute percutaneous toxicity.
(2) repeatedly Skin Irritation Test
1, tested material: " of a specified duration of an established trade mark prostatitis paste " is sepia patch, taking tested material ointment 10g adding distil water, to be modulated into 50% pastel for subsequent use.
2, laboratory animal: provided by Xi'an Jiaotong University Medical College's Experimental Animal Center, Japanese white big ear rabbit 4, male and female half and half, body weight 2.5-3.0kg, primary animal (dynamic No. 08-18th, the word of doctor).
3, animal housing's environment: temperature 22-25 DEG C, relative humidity: 45-55%.The Animal House quality certification number: dynamic No. 08-37th, the word of doctor.
4, test method: test first 24 hours, in every rabbit back spinal column both sides cropping preserved skin, each 3 × 6cm of unhairing scope
2.Only respectively get tested material 0.5g/, be coated on the skin of every rabbit side after modulation, smear every day once, offside all makes solvent control.Smear 14 days continuously.Cropping before being coated with every day, must not injured skin, ensures that tested material fully contacts with skin.Observe dermoreaction and marking every day.Off-test.Get and smear area skin and carry out histopathologic examination.
5, result of the test: in table 2
Table 2: " prostatitis of an established trade mark of a specified duration pastes " is to rabbit repeatedly Skin Irritation Test result
6, evaluate: " prostatitis of an established trade mark of a specified duration pastes " repeatedly the highest stimulation index of skin irritation and pathological tissue integration are 0, according to skin irritation strength grading standard in DB61267-1998 " health product Toxicological evaluation program and test method ", " prostatitis of an established trade mark of a specified duration pastes " repeatedly skin irritation intensity belongs to nonirritant.
(3) skin anaphylactic test
1, tested material: " of a specified duration of an established trade mark prostatitis paste " is sepia patch, taking tested material ointment 10g adding distil water, to be modulated into 50% pastel for subsequent use.Positive control: 2,4-dinitro-chloro-benzene (DNCB), produce in Xing Jin chemical plant, Beijing, lot number 20020522.
2, laboratory animal: provided by Xi'an Jiaotong University Medical College's Experimental Animal Center, Cavia porcellus 30, male and female half and half, body weight 250-300g, primary animal.
3, animal housing's environment: temperature 22-25 DEG C, relative humidity: 45-55%.The Animal House quality certification number: dynamic No. 08-37th, the word of doctor.
4, test method: test Cavia porcellus is divided into three groups at random, often organize 10, male and female half and half, are respectively tested material group, negative control group and positive controls.
Sensitization contact: guinea pig back left of spine hair was removed in first 24 hours to tested material, unhairing scope about 3 × 3cm.Get tested material 0.2g/ only, after modulation, even application loses hair or feathers district on the left of back part of animal, continues 6 hours.7th day and the 14th day, use the same method and repeat once, positive controls is coated with 1%DNCB, and negative control group does not deal with.
Excite contact: Yu Weici was to after tested material 14 days, and by tested material 0.2g/ only, even application loses hair or feathers district on the right side of guinea pig back after modulation, removes tested material, at once observe anaphylaxis situation, then again observed in 1,24,48,72 hour after 6 hours.Positive controls is coated with 0.1%DNCB, and negative control group does not deal with.Observational technique is with tested group.Result is evaluated according to sensitization of skin evaluation criterion relevant in DB61-267-1998 " health product Toxicological evaluation program and test method ".
5, result of the test: sensitivity response is scored and table 4 " prostatitis of an established trade mark of a specified duration pastes " sensitization rate in table 3 " prostatitis of an established trade mark of a specified duration pastes ".
Table 4: " prostatitis of an established trade mark of a specified duration pastes " sensitization rate
| Group | Number of animals | Sensitization number | Sensitization rate (%) | Intensity |
| Tested group | 10 | 0 | 0 | Without sensitization |
| Negative control | 10 | 0 | 0 | Without sensitization |
| Positive control | 10 | 10 | 100 | Extremely sensitization |
6, evaluate: according to sensitization of skin standard relevant in DB61-267-1998 " health product Toxicological evaluation program and test method ", " prostatitis of an established trade mark of a specified duration pastes " belongs to without sensitization.Test proves: tested material group sensitization rate is 0.
(4) anti-inflammation test, analgesic test, microcirculation test
1, anti-inflammation test: " prostatitis of an established trade mark of a specified duration pastes " mouse corrosion disease test (ear swelling method) measurement result shows tested group of ear swelling degree and is significantly less than blank group, and diversity has highly significant (P < 0.01).
2, analgesic test: " prostatitis of an established trade mark of a specified duration pastes " mice analgesic test (writhing method) test result shows tested group of writhing number of times and reduces than blank group, and difference has significance (P < 0.05).
3, microcirculation test: " prostatitis of an established trade mark of a specified duration pastes " mice microcirculation test measurement result shows all comparatively blank group increase of tested group of Mice Auricle fine motion, vein bore and capillary vessel number, and difference all has highly significant (P < 0.01).
Evaluate: above-mentioned three result of the tests are the positive, illustrate that " prostatitis of an established trade mark of a specified duration pastes " has antiinflammatory, improves the microcirculatory effect of Mice Auricle and certain analgesic effect.
A () mouse corrosion disease is tested
1, tested material: " prostatitis of an established trade mark of a specified duration pastes " is sepia patch, is provided by Shanxi Jianmin Pharmacy Co., Ltd..
2, laboratory animal: provide ICR mice 30 by Traditional Chinese Medicine Research Institute, Shanxi Province Experimental Animal Center, male and female half and half, body weight 18-22g, primary animal (dynamic No. 08-24th, the word of doctor).
3, animal housing's environment: temperature 22-25 DEG C, relative humidity: 45-55%.The Animal House quality certification number: dynamic No. 08-37th, the word of doctor.
4, reagent: dimethylbenzene (analytical pure), Tianjin Deng Feng chemical reagent factory is produced, and makes proinflammatory agent; QIZHENG XIAOTONG TIE, Fromlingzhi, tibet Qizheng Tibetan Medicine factory provides, and lot number 051289 is as positive control.
5, key instrument: YLS-Q4 ear is swollen makes ear device, FA2004 type analysis balance.
6, tested material dosage: 0.2g/ only, and taking tested material ointment 10g adding distil water, to be modulated into 50% pastel for subsequent use.
7, test method: adopt mice ear method, 30 mices are divided into 3 groups at random, often organizes 10, i.e. blank group, tested material group and positive controls.Positive controls, test component are not coated with positive drug 0.2g and tested material 0.2g to mouse right ear, blank group does not deal with, be applied to each group of mouse right ear with dimethylbenzene (0.03ml/ only) after 30min and cause inflammation, after 15min, de-cervical vertebra puts to death mice, lays round auricle respectively with 8mm diameter card punch at the same position of ear, left and right two.Weigh in FA2004 type electronic analytical balance, every Mus auris dextra sheet weight deducts left auricle weight and is this Mus inflammatory tissue swelling, and tested group of ear swelling degree compares with blank group, and experimental data is processed by SPSS11.5 software.
8, the results are shown in Table 5:
Table 5: " prostatitis of an established trade mark of a specified duration pastes " impact on mice ear degree
9, conclusion: the tested group of scorching ear swelling degree of mice caused by dimethylbenzene xylene is significantly less than blank group, and difference has highly significant (P < 0.01), illustrates that " prostatitis of an established trade mark of a specified duration pastes " that the present invention produces has antiinflammatory action.
(b) mice analgesic test (writhing method)
1, tested material: " prostatitis of an established trade mark of a specified duration pastes " is sepia patch, is provided by Shanxi Jianmin Pharmacy Co., Ltd..
2, laboratory animal: provide ICR mice 30 by Traditional Chinese Medicine Research Institute, Shanxi Province Experimental Animal Center, male, body weight 18-22g, primary animal (dynamic No. 08-24th, the word of doctor).
3, animal housing's environment: temperature 22-25 DEG C, relative humidity: 45-55%.The Animal House quality certification number: dynamic No. 08-37th, the word of doctor.
4, reagent: acetic acid (analytical pure), Tianjin Deng Feng chemical reagent factory is produced, and makes algogen.Spasmolysis and analgesia tincture, Xing Hai pharmaceutical Co. Ltd of Changshu City produces, as positive control.
5, tested material dosage: 0.5g/ only, and taking tested material ointment 10g adding distil water, to be modulated into 50% pastel for subsequent use.
6, test method: adopt mouse writhing method, 30 mices are divided into 3 groups at random, be respectively tested group, positive controls, blank group, often group 10.Blank group every Mus lumbar injection 0.6% acetic acid 0.1ml/10g.bw, with each Mus writhing number of times in 15min after counter records injection algogen, tested group and positive controls respectively through abdominal part external to tested material and spasmolysis and analgesia tincture, record mouse writhing number of times by the method injection acetic acid of blank group after 30min.Tested group of result compares with blank group, and experimental data is processed by SPSS11.5 software.
7, the results are shown in Table 6:
Table 6: " prostatitis of an established trade mark of a specified duration pastes " is on mice pain reaction impact
8, conclusion: tested group of mouse writhing number of times reduces than blank group, and difference has significance (P < 0.05), illustrates that " prostatitis of an established trade mark of a specified duration pastes " that the present invention produces has certain analgesic activity.
(c) mice microcirculation test:
1, tested material: " prostatitis of an established trade mark of a specified duration pastes " is sepia patch, is provided by Shanxi Jianmin Pharmacy Co., Ltd..
2, laboratory animal: provide ICR mice 30 by Traditional Chinese Medicine Research Institute, Shanxi Province Experimental Animal Center, male, body weight 18-22g, primary animal (dynamic No. 08-24th, the word of doctor), feedstuff bedding and padding source is the same.
3, animal housing's environment: temperature 22-25 DEG C, relative humidity: 45-55%.The Animal House quality certification number: dynamic No. 08-37th, the word of doctor.
4, reagent: pentobarbital sodium, Solution on Chemical Reagents in Shanghai purchasing and supply station provides, lot number 75-01-03, is made into 1% concentration for subsequent use; Adrenalin hydrochloride injection, Tianjin KingYork Amino Acid Co., Ltd. produces, lot number 0503311; QIZHENG XIAOTONG TIE, Fromlingzhi, tibet Qizheng Tibetan Medicine factory provides, lot number 051289.
5, instrument: BI-2000 image analysis system.
6, tested material dosage: 0.2g/ only, and taking tested material ointment 10g adding distil water, to be modulated into 50% pastel for subsequent use.
7, test method: 30 mices are divided into 3 groups at random, be respectively tested group, positive controls, blank group, often organize 10.Blank group does not deal with; The every Mus auris dextra of positive controls is coated with QIZHENG XIAOTONG TIE; Tested group of every Mus auris dextra is coated with tested material.Within 15 minutes, pneumoretroperitoneum injects 1% pentobarbital sodium 0.1ml/10g.bw anesthetized animal, tail vein injection 0.1% epinephrine 0.1ml/10g.bw subsequently, immediately with the capillary vessel number that the fine motion of XSZ-H series of biologic micro-border observation mouse right ear, vein bore (um) and diameter are within the scope of 0.2mm.Tested group of result compares with blank group, and experimental data is processed by SPSS11.5 software.
8, the results are shown in Table 7:
Table 7: " of a specified duration of an established trade mark prostatitis paste " is on the impact of Mice Auricle fine motion vein bore and capillary open number
9, conclusion: tested group of Mice Auricle fine motion, vein bore and capillary vessel number all comparatively blank group obviously increase, and difference all has highly significant (P < 0.01), illustrate that " prostatitis of an established trade mark of a specified duration pastes " that the present invention produces has and improve the microcirculatory effect of Mice Auricle.
Experiment proves, the present invention has: 1, acute dermal toxicity result of the test belongs to nontoxic level; 2, repeatedly Skin Irritation Test result belongs to nonirritant; 3, skin anaphylactic test result belongs to without sensitization; 4, antiinflammatory, analgesia, microcirculation test result show, the present invention has antiinflammatory, improves microcirculation and analgesic effect.
Claims (2)
1. treat a Chinese medicine composition for prostatitis and prostatic hyperplasia, it is characterized in that the externally applied plaster paste formulation type be made up of the raw material of following weight number ratio:
2. a kind of preparation method for the treatment of the Chinese medicine composition of prostatitis and prostatic hyperplasia described in production claim 1, is characterized in that:
A. medical material is made rear for subsequent use only;
B. Borneolum Syntheticum, ethyl hydroxybenzoate add appropriate amount of ethanol and dissolve for subsequent use;
C. Olibanum, Myrrha are freezing, pulverize, and crossing 80-100 order, to make into fine powder for subsequent use;
D. Rhizoma Curcumae Longae, Rhizoma Cyperi 50 DEG C of-60 DEG C of cold drying, pulverize, and after 100-120 order makes into fine powder excessively, add c item traditional Chinese medicine fine powder, stir, mixing, and fine powder is for subsequent use;
E. Semen Vaccariae, Radix Cyathulae, Rhizoma Smilacis Glabrae, Rhizoma Bolbostematis, Fructus Corni, Herba Epimedii add 8 times, 6 times weight water, and decoct 2 times, decocting time is respectively 2 hours, 1 hour, collecting decoction, filter, filtrate reduced in volume is to relative density 1.25-1.30,60 DEG C of clear paste surveyed, for subsequent use;
F. after vaseline, lanoline heating and melting, under continuous equidirectional stirring, slowly add clear paste and propylene glycol, azone under e item, continue to stir, mixing, when temperature is down to 45 ~ 50 DEG C, then to add under d item solution under fine powder and b item respectively, stirs, mixing, makes 1000 subsides, often pastes 5g;
G. subpackage, packaging,
60co irradiation dose 5kGy sterilizes, and puts in storage for subsequent use.
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| CN103505695B true CN103505695B (en) | 2015-07-08 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101167892A (en) * | 2007-10-27 | 2008-04-30 | 张金刚 | Traditional Chinese medicinal liquid agent for treating chronic prostatitis |
| CN101721528A (en) * | 2009-12-30 | 2010-06-09 | 长春中医药大学 | Medicine composition for treating chronic prostatitis |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101167892A (en) * | 2007-10-27 | 2008-04-30 | 张金刚 | Traditional Chinese medicinal liquid agent for treating chronic prostatitis |
| CN101721528A (en) * | 2009-12-30 | 2010-06-09 | 长春中医药大学 | Medicine composition for treating chronic prostatitis |
Non-Patent Citations (2)
| Title |
|---|
| 安前汤治疗慢性前列腺炎阳痿81例;刘臣等;《辽宁中医杂志》;20050831;第32卷(第8期);第804页 * |
| 慢性前列腺炎临床辨治体会;陈泺阳;《中国民康医学》;20081031;第20卷(第20期);第2394页 * |
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