CN103505611A - Blood lipid reducing composition containing eucommia seed oil and sea buckthorn oil and preparation method of composition - Google Patents
Blood lipid reducing composition containing eucommia seed oil and sea buckthorn oil and preparation method of composition Download PDFInfo
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Abstract
The invention discloses a blood lipid reducing composition containing eucommia seed oil and sea buckthorn oil. The composition comprises the following components by weight percent: 8-36% of eucommia seed oil, 12-64% of sea buckthorn oil and 6-56% of garlic oil. The invention also discloses a preparation method of eucommia seed oil in the traditional Chinese medicine composition. The preparation method comprises the steps of firstly carrying out static extraction under 30-40MPa for 10 minutes and then carrying out dynamic extraction, wherein the inlet pressure is 30-40MPa, the outlet pressure is 5-10kPa lower than the liquid inlet pressure, the temperature is 15-40 DEG C, the time is 0.5-1 hour and the CO2 volume is 20-40kg/h. The composition makes the best of the efficacy of active pharmaceutical ingredients on cardiovascular diseases, adopts scientific matching, generates synergistic effects, has better curative effects and more controllable quality than traditional preparations and is suitable for industrial production.
Description
Technical field
The Chinese medicine composition and the preparation method that the present invention relates to a kind of Cardiovarscular, belong to the field of Chinese medicines.
Background technology
Along with improving constantly of people's living standard, the change of dietary structure, aged tendency of population becomes clear day by day, and the sickness rate of coronary heart disease is day by day soaring.Coronary heart disease is because coronary atherosclerosis causes luminal stenosis, causes blood supply of cardiac muscle oxygen supply obstacle and the heart disease that causes, and " world killer " is known as.With regard to the whole world, since half a century, coronary heart disease has become the underlying cause of death of one of the disease that threat human health the is the most serious ，Shi U.S. and some industrialized country.According to World Health Organization's statistics, in the total death toll of the U.S., have 24.7% to die from coronary heart disease, Northern Ireland coronary heart disease case fatality rate occupies first place in the world, and is 5,36/,100,000; Japan is minimum, is 41,/10 ten thousand.In recent years, the M & M of China's coronary heart disease continues soaring, has every year at present 700,000 people of surpassing to die from coronary heart disease, is the modal a kind of cardiovascular diseases of middle-aged and elderly people, has leapt to as first of internal disease.Visible coronary heart disease has become global public hazards, and American wins cardiopathia for " pestilence in epoch ".
Hyperlipidemia is the risk factor of apoplexy, coronary heart disease, myocardial infarction, sudden death.In addition, hyperlipidemia is also to promote hypertension, an important risk factor of impaired glucose tolerance, diabetes.Hyperlipidemia also can cause fatty liver, liver cirrhosis, cholelithiasis, pancreatitis, retinal hemorrhage, blind, peripheral vascular disease, limping, hyperuricemia.So must pay much attention to the harm of hyperlipidemia, positive prevention and treatment.
Blood lipid-lowering medicine is mainly Statins in the market.Such medicine has good lipid-lowering effect, but long-term taking, can be just like myalgia, muscle inflammation, even the musclar toxicity such as rhabdomyolysis, also can produce the side effect such as internal metabolism obstacle, gastrointestinal side effect, liver loss.Meanwhile, statins price is high, and long-term taking also can the corresponding financial burden that increases patient.
So, provide controlled, cheap, the eutherapeutic pure natural plant of a kind of safety to extract medicine, there is great social meaning and economic worth.
Summary of the invention
The object of the invention is a kind of good effect, the more controlled Chinese medicine composition of quality.
Another object of the present invention is a kind of preparation method of described Chinese medicine composition.
Another object of the present invention is to provide a kind ofly has the Chinese medicine composition of the market competitiveness in price equally.Described Chinese medicine composition can not increase because of the raising of curative effect patient's financial burden.
For achieving the above object, the present invention by the following technical solutions:
In Chinese medicine composition of the present invention, comprise the component of following percentage by weight:
Eucommia ulmoides seed oil 8～36%; Oleum Hippophae 12～64%; Oleum Bulbus Allii 6～56%;
Preferably, in Chinese medicine composition of the present invention, comprise the component of following percentage by weight:
Eucommia ulmoides seed oil 12～32%; Oleum Hippophae 18～60%; Oleum Bulbus Allii 10～50%;
Preferred, in Chinese medicine composition of the present invention, comprise the component of following percentage by weight:
Eucommia ulmoides seed oil 18～28%; Oleum Hippophae 32～50%; Oleum Bulbus Allii 24～42%;
Further preferred, in Chinese medicine composition of the present invention, comprise the component of following percentage by weight:
Eucommia ulmoides seed oil 24%; Oleum Hippophae 40%; Oleum Bulbus Allii 36%.
In the present composition, Oleum Hippophae can be buied from open market, also can adopt following methods preparation.
In the present composition, the preparation method of Oleum Hippophae comprises the following steps:
The first static extracting 10min of 30～40MPa, dynamic extraction then, inlet pressure is 30～40MPa, outlet pressure is than the low 5～10kPa of inlet pressure; 15～40 ℃ of temperature, time 0.5～1h, CO
2volume 20-40kg/h.
Preferably, the first static extracting 10min of 40MPa, dynamic extraction then, inlet pressure is 35MPa, outlet pressure is than the low 5kPa of inlet pressure; 25 ℃ of temperature, time 1h, CO
2volume 30kg/h.
In the process of extraction separately or combine the following method that adopts: periodic pressure fluctuation, periodically flow fluctuation; Wherein the pressure wave moment of periodic pressure fluctuation is 5～10Mpa, and periodically the flow speed wave moment of flow fluctuation is 1.0～3.0 meter per seconds.
Oleum Hippophae oil yield can reach 10.68～12.45%.
Dynamic CO of the present invention
2oleum Hippophae prepared by extraction need not carry out separation again, free from admixture in oil, and the color of oil is pale yellow transparent, and fragrance is pure.
Oleum Bulbus Allii of the present invention and eucommia ulmoides seed oil can be buied from open market, also can adopt said method preparation.
Chinese medicine composition of the present invention, the various dosage forms that can be mixed as starch, dextrin, lactose, microcrystalline Cellulose, hydroxypropyl methylcellulose, Polyethylene Glycol, magnesium stearate, micropowder silica gel, xylitol, lactose, glucose, glycine, mannitol, glycine etc. with adjuvant on any or more than one pharmaceuticss, for example, can be made into aqueous injection, tablet, slow releasing tablet, drop pill, granule, injectable powder, capsule, microgranule.Preferred dosage form is drop pill, soft capsule.
In compositions of the present invention, can also in the situation that not affecting therapeutic purposes of the present invention and effect, add arbitrarily other compositions or the component in the present invention is equal to replacement, including but not limited to that Borneolum Syntheticum, Flos Carthami, Radix Curcumae, Rhizoma Corydalis are or/and Lignum Dalbergiae Odoriferae etc.As long as add the compositions obtaining after these compositions can also reach the therapeutic effect of the present composition, be all fine.
Chinese medicine composition of the present invention makes full use of the therapeutical effect of crude drug to cardiovascular disease, carries out scientific matching, produces coordinating effect, good effect, and quality is more controlled, is applicable to suitability for industrialized production.
test example
Medicine blood fat reducing clinical observation of the present invention
1. data and method
1.1 physical data are selected hyperlipidemia patient 80 examples at random, male 40 examples, and female's 40 examples, at 45～74 years old age, average 58.3 years old, selecting 80 routine hyperlipidemia patients else was matched group, male 43 examples, female's 37 examples, 44～75 years old age, 57.6 years old mean age.
1.2 administrated method
Treatment group adopts the embodiment of the present invention 4 medicines, each 10mg, oral 3 times of every day, 2 months courses for the treatment of.Matched group gives Xuezhikang, each 10mg, every day 3 times, 2 months courses for the treatment of.Before treatment, withdraw other hypolipidemic.All patients before treatment, treatment does hematuria routine, blood fat, liver function, renal function, serum potassium, uranium, chlorine, blood glucose, Electrocardioscopy after January and the course for the treatment of finishing.
1.3 observation item
Before and after treatment, take out limosis vein blood and detect serum total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL-C), low density lipoprotein, LDL (LDL-C), do liver function, renal function, blood, urine routine test simultaneously.
1.4 statistical procedures
Mean ± standard deviation for measurement data (
) represent, adopt t check; Enumeration data x
2check, P < 0.05 has significance for difference.
2. result
The curative effect of hyperlipidemia
Before and after table 1 liang group lipid therapy, compare (
)
Note: before and after * group internal therapy than P < 0.01, between # group after treatment than P < 0.01.
The present invention and Xuezhikang all have lipid-lowering effect, and present composition lipid-lowering effect is better than Xuezhikang.
The specific embodiment
embodiment 1
The first static extracting 10min of 30MPa, dynamic extraction then, inlet pressure is 30MPa, outlet pressure is than the low 5kPa of inlet pressure; 15 ℃ of temperature, time 0.5h, CO
2volume 20kg/h.
In the process of extraction, combine the following method that adopts: periodic pressure fluctuation, periodically flow fluctuation; Wherein the pressure wave moment of periodic pressure fluctuation is 5～10Mpa, and periodically the flow speed wave moment of flow fluctuation is 1.0～3.0 meter per seconds.
Oleum Hippophae oil yield can reach 10.88%.
Take by weight eucommia ulmoides seed oil 8%; Oleum Hippophae 36%; Oleum Bulbus Allii 56%, adds adjuvant and is prepared into Chinese medicine composition of the present invention.
embodiment 2
The first static extracting 10min of 40MPa, dynamic extraction then, inlet pressure is 40MPa, outlet pressure is than the low 10kPa of inlet pressure; 40 ℃ of temperature, time 1h, CO
2volume 40kg/h.
In the process of extraction separately or combine the following method that adopts: periodic pressure fluctuation, periodically flow fluctuation; Wherein the pressure wave moment of periodic pressure fluctuation is 5～10Mpa, and periodically the flow speed wave moment of flow fluctuation is 1.0～3.0 meter per seconds.
Oleum Hippophae oil yield can reach 11.68%.
Take by weight eucommia ulmoides seed oil 36%; Oleum Hippophae 12%; Oleum Bulbus Allii 52%, adds adjuvant and is prepared into Chinese medicine composition of the present invention.
embodiment 3
The first static extracting 10min of 30MPa, dynamic extraction then, inlet pressure is 40MPa, outlet pressure is than the low 10kPa of inlet pressure; 20 ℃ of temperature, time 0.5h, CO
2volume 20kg/h.
In the process of extraction separately or combine the following method that adopts: periodic pressure fluctuation, periodically flow fluctuation; Wherein the pressure wave moment of periodic pressure fluctuation is 5～10Mpa, and periodically the flow speed wave moment of flow fluctuation is 1.0～3.0 meter per seconds.
Oleum Hippophae oil yield can reach 11.96%.
Take by weight eucommia ulmoides seed oil 12%; Oleum Hippophae 38%; Oleum Bulbus Allii 50%, adds adjuvant and is prepared into Chinese medicine composition of the present invention.
embodiment 4
The first static extracting 10min of 40MPa, dynamic extraction then, inlet pressure is 35MPa, outlet pressure is than the low 5kPa of inlet pressure; 25 ℃ of temperature, time 1h, CO
2volume 30kg/h.
In the process of extraction separately or combine the following method that adopts: periodic pressure fluctuation, periodically flow fluctuation; Wherein the pressure wave moment of periodic pressure fluctuation is 10Mpa, and periodically the flow speed wave moment of flow fluctuation is 3.0 meter per seconds.
Oleum Hippophae oil yield can reach 12.45%.
Take by weight eucommia ulmoides seed oil 24%; Oleum Hippophae 40%; Oleum Bulbus Allii 36%, adds adjuvant and is prepared into Chinese medicine composition of the present invention.
embodiment 5
The first static extracting 10min of 40MPa, dynamic extraction then, inlet pressure is 30MPa, outlet pressure is than the low 10kPa of inlet pressure; 30 ℃ of temperature, time 1h, CO
2volume 30kg/h.
In the process of extraction separately or combine the following method that adopts: periodic pressure fluctuation, periodically flow fluctuation; Wherein the pressure wave moment of periodic pressure fluctuation is 5～10Mpa, and periodically the flow speed wave moment of flow fluctuation is 3.0 meter per seconds.
Oleum Hippophae oil yield can reach 11.17%.
Take by weight eucommia ulmoides seed oil 32%; Oleum Hippophae 18%; Oleum Bulbus Allii 50%, adds adjuvant and is prepared into Chinese medicine composition of the present invention.
embodiment 6
The first static extracting 10min of 35MPa, dynamic extraction then, inlet pressure is 35MPa, outlet pressure is than the low 10kPa of inlet pressure; 35 ℃ of temperature, time 1h, CO
2volume 40kg/h.
In the process of extraction, combine the following method that adopts: periodic pressure fluctuation, periodically flow fluctuation; Wherein the pressure wave moment of periodic pressure fluctuation is 5～10Mpa, and periodically the flow speed wave moment of flow fluctuation is 2.0 meter per seconds.
Oleum Hippophae oil yield can reach 12.05%.
Take by weight eucommia ulmoides seed oil 28%; Oleum Hippophae 32%; Oleum Bulbus Allii 40%, adds adjuvant and is prepared into Chinese medicine composition of the present invention.
embodiment 7
The first static extracting 10min of 40MPa, dynamic extraction then, inlet pressure is 40MPa, outlet pressure is than the low 5kPa of inlet pressure; 35 ℃ of temperature, time 1h, CO
2volume 25kg/h.
In the process of extraction, combine the following method that adopts: periodic pressure fluctuation, periodically flow fluctuation; Wherein the pressure wave moment of periodic pressure fluctuation is 5Mpa, and periodically the flow speed wave moment of flow fluctuation is 2.0 meter per seconds.
Oleum Hippophae oil yield can reach 11.74%.
Radix Salviae Miltiorrhizae takes eucommia ulmoides seed oil 18% by weight; Oleum Hippophae 50%; Oleum Bulbus Allii 32%, adds adjuvant and is prepared into Chinese medicine composition of the present invention.
embodiment 8
The first static extracting 10min of 30MPa, dynamic extraction then, inlet pressure is 30MPa, outlet pressure is than the low 6kPa of inlet pressure; 20 ℃ of temperature, time 1h, CO
2volume 40kg/h.
Oleum Hippophae oil yield can reach 10.71%.
Take by weight eucommia ulmoides seed oil 30%; Oleum Hippophae 50%; Oleum Bulbus Allii 20%, adds adjuvant and is prepared into Chinese medicine composition of the present invention.
embodiment 9
The first static extracting 10min of 40MPa, dynamic extraction then, inlet pressure is 30MPa, outlet pressure is than the low 8kPa of inlet pressure; 25 ℃ of temperature, time 1h, CO
2volume 25kg/h.
Oleum Hippophae oil yield can reach 10.94%.
Take by weight eucommia ulmoides seed oil 25%; Oleum Hippophae 45%; Oleum Bulbus Allii 30%, adds adjuvant and is prepared into Chinese medicine composition of the present invention.
embodiment 10
The first static extracting 10min of 28MPa, dynamic extraction then, inlet pressure is 28MPa, outlet pressure is than the low 5kPa of inlet pressure; 15 ℃ of temperature, time 1h, CO
2volume 28kg/h.
In the process of extraction, combine the following method that adopts: periodic pressure fluctuation, periodically flow fluctuation; Wherein the pressure wave moment of periodic pressure fluctuation is 8Mpa, and periodically the flow speed wave moment of flow fluctuation is 3.0 meter per seconds.
Oleum Hippophae oil yield can reach 12.15%.
Take by weight eucommia ulmoides seed oil 28%; Oleum Hippophae 38%; Oleum Bulbus Allii 34%, adds adjuvant and is prepared into Chinese medicine composition of the present invention.
embodiment 11
The first static extracting 10min of 38MPa, dynamic extraction then, inlet pressure is 38MPa, outlet pressure is than the low 7kPa of inlet pressure; 37 ℃ of temperature, time 1h, CO
2volume 38kg/h.
In the process of extraction, combine the following method that adopts: periodic pressure fluctuation, periodically flow fluctuation; Wherein the pressure wave moment of periodic pressure fluctuation is 9Mpa, and periodically the flow speed wave moment of flow fluctuation is 3.0 meter per seconds.
Oleum Hippophae oil yield can reach 12.31%.
Take by weight eucommia ulmoides seed oil 24%; Oleum Hippophae 48%; Oleum Bulbus Allii 28%, adds adjuvant and is prepared into Chinese medicine composition of the present invention.
embodiment 12
The first static extracting 10min of 35MPa, dynamic extraction then, inlet pressure is 35MPa, outlet pressure is than the low 10kPa of inlet pressure; 30 ℃ of temperature, time 1h, CO
2volume 25kg/h.
Oleum Hippophae oil yield can reach 10.98%.
Take by weight eucommia ulmoides seed oil 26%; Oleum Hippophae 56%; Oleum Bulbus Allii 18%, adds adjuvant and is prepared into Chinese medicine composition of the present invention.
embodiment 13
The first static extracting 10min of 40MPa, dynamic extraction then, inlet pressure is 35MPa, outlet pressure is than the low 8kPa of inlet pressure; 20 ℃ of temperature, time 0.5h, CO
2volume 25kg/h.
In the process of extraction, combine the following method that adopts: periodic pressure fluctuation, periodically flow fluctuation; Wherein the pressure wave moment of periodic pressure fluctuation is 9Mpa, and periodically the flow speed wave moment of flow fluctuation is 3.0 meter per seconds.
Oleum Hippophae oil yield can reach 11.45%.
Take by weight eucommia ulmoides seed oil 10%; Oleum Hippophae 60%; Oleum Bulbus Allii 30%, adds adjuvant and is prepared into Chinese medicine composition of the present invention.
embodiment 14
The first static extracting 10min of 40MPa, dynamic extraction then, inlet pressure is 30～40MPa, outlet pressure is than the low 6kPa of inlet pressure; 36 ℃ of temperature, time 0.5h, CO
2volume 40kg/h.
Oleum Hippophae oil yield can reach 10.85%.
Take by weight eucommia ulmoides seed oil 25%; Oleum Hippophae 55%; Oleum Bulbus Allii 20%, adds adjuvant and is prepared into Chinese medicine composition of the present invention.
embodiment 15
The first static extracting 10min of 30MPa, dynamic extraction then, inlet pressure is 40MPa, outlet pressure is than the low 5kPa of inlet pressure; 30 ℃ of temperature, time 1h, CO
2volume 25kg/h.
In the process of extraction, combine the following method that adopts: periodic pressure fluctuation, periodically flow fluctuation; Wherein the pressure wave moment of periodic pressure fluctuation is 7Mpa, and periodically the flow speed wave moment of flow fluctuation is 2.5 meter per seconds.
Oleum Hippophae oil yield can reach 12.12%.
Take by weight eucommia ulmoides seed oil 32%; Oleum Hippophae 32%; Oleum Bulbus Allii 36%, adds adjuvant and is prepared into Chinese medicine composition of the present invention.
embodiment 16
The first static extracting 10min of 35MPa, dynamic extraction then, inlet pressure is 40MPa, outlet pressure is than the low 10kPa of inlet pressure; 33 ℃ of temperature, time 1h, CO
2volume 25kg/h.
In the process of extraction, combine the following method that adopts: periodic pressure fluctuation, periodically flow fluctuation; Wherein the pressure wave moment of periodic pressure fluctuation is 8Mpa, and periodically the flow speed wave moment of flow fluctuation is 3.0 meter per seconds.
Oleum Hippophae oil yield can reach 11.96%.
Take by weight eucommia ulmoides seed oil 22%; Oleum Hippophae 42%; Oleum Bulbus Allii 36%, adds adjuvant and is prepared into Chinese medicine composition of the present invention.
embodiment 17
The first static extracting 10min of 35MPa, dynamic extraction then, inlet pressure is 30MPa, outlet pressure is than the low 7kPa of inlet pressure; 40 ℃ of temperature, time 1h, CO
2volume 40kg/h.
In the process of extraction, combine the following method that adopts: periodic pressure fluctuation, periodically flow fluctuation; Wherein the pressure wave moment of periodic pressure fluctuation is 6Mpa, and periodically the flow speed wave moment of flow fluctuation is 1.0 meter per seconds.
Oleum Hippophae oil yield can reach 12.29%.
Take by weight eucommia ulmoides seed oil 21%; Oleum Hippophae 48%; Oleum Bulbus Allii 31%, adds adjuvant and is prepared into Chinese medicine composition of the present invention.
embodiment 18
The first static extracting 10min of 34MPa, dynamic extraction then, inlet pressure is 35MPa, outlet pressure is than the low 10kPa of inlet pressure; 38 ℃ of temperature, time 1h, CO
2volume 40kg/h.
In the process of extraction, combine the following method that adopts: periodic pressure fluctuation, periodically flow fluctuation; Wherein the pressure wave moment of periodic pressure fluctuation is 5Mpa, and periodically the flow speed wave moment of flow fluctuation is 1.0 meter per seconds.
Oleum Hippophae oil yield can reach 12.36%.
Take by weight eucommia ulmoides seed oil 8～36%; Oleum Hippophae 12～64%; Oleum Bulbus Allii 6～56%, adds adjuvant and is prepared into Chinese medicine composition of the present invention.
embodiment 19
The first static extracting 10min of 32MPa, dynamic extraction then, inlet pressure is 32MPa, outlet pressure is than the low 5kPa of inlet pressure; 20 ℃ of temperature, time 1h, CO
2volume 40kg/h.
In the process of extraction, combine the following method that adopts: periodic pressure fluctuation, periodically flow fluctuation; Wherein the pressure wave moment of periodic pressure fluctuation is 9Mpa, and periodically the flow speed wave moment of flow fluctuation is 3.0 meter per seconds.
Oleum Hippophae oil yield can reach 11.79%.
Take by weight eucommia ulmoides seed oil 32%; Oleum Hippophae 16%; Oleum Bulbus Allii 52%, adds adjuvant and is prepared into Chinese medicine composition of the present invention.
embodiment 20
The first static extracting 10min of 40MPa, dynamic extraction then, inlet pressure is 40MPa, outlet pressure is than the low 5kPa of inlet pressure; 25 ℃ of temperature, time 0.5h, CO
2volume 25kg/h.
In the process of extraction, combine the following method that adopts: periodic pressure fluctuation, periodically flow fluctuation; Wherein the pressure wave moment of periodic pressure fluctuation is 10Mpa, and periodically the flow speed wave moment of flow fluctuation is 1.0 meter per seconds.
Oleum Hippophae oil yield can reach 11.63%.
Take by weight eucommia ulmoides seed oil 36%; Oleum Hippophae 32%; Oleum Bulbus Allii 32%, adds adjuvant and is prepared into Chinese medicine composition of the present invention.
embodiment 21
The first static extracting 10min of 32MPa, dynamic extraction then, inlet pressure is 32MPa, outlet pressure is than the low 9kPa of inlet pressure; 40 ℃ of temperature, time 1h, CO
2volume 40kg/h.
In the process of extraction, combine the following method that adopts: periodic pressure fluctuation, periodically flow fluctuation; Wherein the pressure wave moment of periodic pressure fluctuation is 5Mpa, and periodically the flow speed wave moment of flow fluctuation is 3.0 meter per seconds.
Oleum Hippophae oil yield can reach 12.01%.
Take by weight eucommia ulmoides seed oil 28%; Oleum Hippophae 42%; Oleum Bulbus Allii 30%, adds adjuvant and is prepared into Chinese medicine composition of the present invention.
embodiment 22
The first static extracting 10min of 35MPa, dynamic extraction then, inlet pressure is 35MPa, outlet pressure is than the low 10kPa of inlet pressure; 15 ℃ of temperature, time 0.5h, CO
2volume 40kg/h.
In the process of extraction, combine the following method that adopts: periodic pressure fluctuation, periodically flow fluctuation; Wherein the pressure wave moment of periodic pressure fluctuation is 10Mpa, and periodically the flow speed wave moment of flow fluctuation is 3.0 meter per seconds.
Oleum Hippophae oil yield can reach 11.74%.
Take by weight eucommia ulmoides seed oil 36%; Oleum Hippophae 14%; Oleum Bulbus Allii 50%, adds adjuvant and is prepared into Chinese medicine composition of the present invention.
embodiment 23
The first static extracting 10min of 34MPa, dynamic extraction then, inlet pressure is 34MPa, outlet pressure is than the low 10kPa of inlet pressure; 40 ℃ of temperature, time 1h, CO
2volume 35kg/h.
In the process of extraction, combine the following method that adopts: periodic pressure fluctuation, periodically flow fluctuation; Wherein the pressure wave moment of periodic pressure fluctuation is 5Mpa, and periodically the flow speed wave moment of flow fluctuation is 3.0 meter per seconds.
Oleum Hippophae oil yield can reach 11.39%.
Take by weight eucommia ulmoides seed oil 12%; Oleum Hippophae 53%; Oleum Bulbus Allii 35%, adds adjuvant and is prepared into Chinese medicine composition of the present invention.
embodiment 24
The first static extracting 10min of 39MPa, dynamic extraction then, inlet pressure is 39MPa, outlet pressure is than the low 10kPa of inlet pressure; 25 ℃ of temperature, time 1h, CO
2volume 30kg/h.
In the process of extraction, combine the following method that adopts: periodic pressure fluctuation, periodically flow fluctuation; Wherein the pressure wave moment of periodic pressure fluctuation is 10Mpa, and periodically the flow speed wave moment of flow fluctuation is 3.0 meter per seconds.
Oleum Hippophae oil yield can reach 11.89%.
Take by weight eucommia ulmoides seed oil 21%; Oleum Hippophae 42%; Oleum Bulbus Allii 37%, adds adjuvant and is prepared into Chinese medicine composition of the present invention.
embodiment 25
The first static extracting 10min of 30MPa, dynamic extraction then, inlet pressure is 40MPa, outlet pressure is than the low 10kPa of inlet pressure; 36 ℃ of temperature, time 0.5h, CO
2volume 27kg/h.
In the process of extraction, combine the following method that adopts: periodic pressure fluctuation, periodically flow fluctuation; Wherein the pressure wave moment of periodic pressure fluctuation is 7Mpa, and periodically the flow speed wave moment of flow fluctuation is 2.5 meter per seconds.
Oleum Hippophae oil yield can reach 12.19%.
Take by weight eucommia ulmoides seed oil 18%; Oleum Hippophae 64%; Oleum Bulbus Allii 18%, adds adjuvant and is prepared into Chinese medicine composition of the present invention.
Embodiments of the invention are only the specific descriptions to technical scheme, are not the restrictions to technical scheme, and those skilled in the art all fall into protection scope of the present invention not changing the replacement done under the condition of flesh and blood of the present invention or change.
Claims (8)
1. a blood-fat reducing composition that contains eucommia ulmoides seed oil and Oleum Hippophae, comprises the component of following weight portion: eucommia ulmoides seed oil 8～36%; Oleum Hippophae 12～64%; Oleum Bulbus Allii 6～56%.
2. compositions according to claim 1, is characterized in that, comprises the component of following percentage by weight: eucommia ulmoides seed oil 12～32%; Oleum Hippophae 18～60%; Oleum Bulbus Allii 10～50%.
3. compositions according to claim 2, is characterized in that, comprises the component of following percentage by weight: eucommia ulmoides seed oil 18～28%; Oleum Hippophae 32～50%; Oleum Bulbus Allii 24～42%.
4. compositions according to claim 3, is characterized in that, comprises the component of following percentage by weight: eucommia ulmoides seed oil 24%; Oleum Hippophae 40%; Oleum Bulbus Allii 36%.
5. the preparation method of the Oleum Hippophae described in the arbitrary claim of claim 1～4, comprises the following steps: the first static extracting 10min of 30～40MPa, and dynamic extraction then, inlet pressure is 30～40MPa, outlet pressure is than the low 5～10kPa of inlet pressure; 15～40 ℃ of temperature, time 0.5～1h, CO
2volume 20-40kg/h.
6. preparation method according to claim 5, is characterized in that, comprises the following steps: the first static extracting 10min of 40MPa, and dynamic extraction then, inlet pressure is 35MPa, outlet pressure is than the low 5kPa of inlet pressure; 25 ℃ of temperature, time 1h, CO
2volume 30kg/h.
7. according to the preparation method described in claim 5 or 6, it is characterized in that, in the process of extraction separately or combine the following method that adopts: periodic pressure fluctuation, periodically flow fluctuation; Wherein the pressure wave moment of periodic pressure fluctuation is 5～10Mpa, and periodically the flow speed wave moment of flow fluctuation is 1.0～3.0 meter per seconds.
8. preparation method according to claim 7, is characterized in that, Oleum Hippophae oil yield can reach 10.68～12.45%.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104886565A (en) * | 2015-05-07 | 2015-09-09 | 张海龙 | Eucommia ulmoides brain strengthening oral liquid and a production method thereof |
| CN109106840A (en) * | 2017-06-22 | 2019-01-01 | 无限极（中国）有限公司 | A kind of vegetable oil composition with cardiovascular protection and preparation method thereof and product |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2567996Y (en) * | 2002-08-30 | 2003-08-27 | 张海龙 | Soft capsule of Eucommia ulmoides seed oil |
| CN102429223A (en) * | 2011-11-11 | 2012-05-02 | 完美（中国）有限公司 | Health care food with assistant blood fat reducing function and preparation method thereof |
| CN102504944A (en) * | 2011-11-21 | 2012-06-20 | 广元亿明生物科技有限公司 | Extraction method of eucommia seed oil |
-
2012
- 2012-06-28 CN CN201210217257.3A patent/CN103505611A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2567996Y (en) * | 2002-08-30 | 2003-08-27 | 张海龙 | Soft capsule of Eucommia ulmoides seed oil |
| CN102429223A (en) * | 2011-11-11 | 2012-05-02 | 完美（中国）有限公司 | Health care food with assistant blood fat reducing function and preparation method thereof |
| CN102504944A (en) * | 2011-11-21 | 2012-06-20 | 广元亿明生物科技有限公司 | Extraction method of eucommia seed oil |
Non-Patent Citations (1)
| Title |
|---|
| 孙以方等: "沙棘油对大鼠实验性高血脂的影响", 《兰州医学院学报》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104886565A (en) * | 2015-05-07 | 2015-09-09 | 张海龙 | Eucommia ulmoides brain strengthening oral liquid and a production method thereof |
| CN109106840A (en) * | 2017-06-22 | 2019-01-01 | 无限极（中国）有限公司 | A kind of vegetable oil composition with cardiovascular protection and preparation method thereof and product |
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