CN103505575A - Hemostatic traditional Chinese medicine composition and application thereof - Google Patents
Hemostatic traditional Chinese medicine composition and application thereof Download PDFInfo
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- CN103505575A CN103505575A CN201310436535.9A CN201310436535A CN103505575A CN 103505575 A CN103505575 A CN 103505575A CN 201310436535 A CN201310436535 A CN 201310436535A CN 103505575 A CN103505575 A CN 103505575A
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Abstract
The invention belongs to the field of traditional Chinese medicine, and particularly relates to a hemostatic traditional Chinese medicine composition and application thereof. The hemostatic traditional Chinese medicine composition comprises the following raw materials in parts by weight: carbonized human hair 5-20, carbonized Pollen Typhae 10-20, and carbonized Rheum officinale. The formulation is simple, only three traditional Chinese medicinal raw materials are used for compounding, and good properties of raw materials and complementary effect thereof are fully utilized, resulting in a distinct drug effect. The hemostatic traditional Chinese medicine composition has effects of stopping bleeding, promoting tissue regeneration, supporting healthy energy, and the like, and reduces cost. The hemostatic prepared based on the composition is convenient in application, has good hemostatic effect and no wound infection. The preparation method of the hemostatic prepared based on the composition is simple, and suitable for industrial production.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of Hemostatic of traditional herb medicine compositions and application thereof.
Background technology
Blood is the material that body weight for humans is wanted, and all hemorrhage diseases, as effectively hemostasis not in time, cause blood consume, and cause body weak, and threat to life even, therefore the application of hemorrhage has great importance.Existing hemorrhage is of a great variety, and they respectively have advantage, but also respectively has its limitation: the formula having is complicated, nearly tens kinds of components, and some anthemorrhagic speeds are slower, and the course for the treatment of is longer.Western medicine has certain therapeutic effect, often side effect is larger, and price is more expensive, as fibrinolysis class Western medicine, by suppressing the activity factor of plasminogen, plasminogen can not be activated, thereby suppress fibrinous dissolving, represent that medicine has aminocaproic acid, aminomethylbenzoic acid and tranexamic acid etc., this class medicine is better to general chronic oozing of blood effect, hemorrhage and wound hemorrhage effect is poor to cancer, common untoward reaction has headache, dizzy, feel sick, vomiting and diarrhoea etc., to elderly patients and have thrombotic tendency and embolic blood vessel medical history person is forbidden.
Summary of the invention
In view of this, the object of the present invention is to provide a kind of Hemostatic of traditional herb medicine compositions simple, cost is low of filling a prescription; Another object of the present invention is to provide the application of said composition in preparing haemostatic medicament, and the haemostatic medicament that utilizes said composition to prepare is easy to use, haemostatic effect good and wound does not infect, and preparation method is simple to operate, is applicable to suitability for industrialized production.
For achieving the above object, technical scheme of the present invention is:
A compositions, composed of the following components according to listed as parts by weight: Crinis Carbonisatus 5-20 part, Pollen Typhae carbon 10-20 part and charred Radix Et Rhizoma Rhei 5-10 part.
The component pharmacology of Hemostatic of traditional herb medicine compositions of the present invention is as follows:
Crinis Carbonisatus: " Chinese Pharmacopoeia " records Crinis Carbonisatus is the carbide that Crinis Carbonisatus is made, is irregular bulk, pitch-black shinny, has most pores, and body is light, and matter is crisp, with Jiao that has of baked wheaten cake, get angry, and bitter in the mouth.There is the effect of hemostasisization trace, for spitting blood, spitting of blood, spitting of blood, hematuria, metrostaxis, traumatic hemorrhage etc.
The medicinal record of Pollen Typhae starts from Shennong's Herbal, classifies as top gradely, and " Japan hanako materia medica " uses its processed product for first year." Chinese Pharmacopoeia " recorded, Pollen Typhae nature and flavor sweet in the mouth, micro-pungent, property flat; Major function is hemostasis, and blood stasis dispelling is treating stranguria.For spitting blood, epistaxis, spitting of blood, metrorrhagia, traumatic hemorrhage, amenorrhea dysmenorrhea, gastral cavity ventral spine pain, tumbling and swelling, blood strangury and dry pain.In " modern Practical Chinese medicinal ", record Pollen Typhae outer for wound, eczema.At present, the traditional Chinese medical science is commonly used for stasis-resolving hemostatic." Chinese Pharmacopoeia 2005 version, version in 2010 are recorded a kind of processed product that Pollen Typhae carbon is Pollen Typhae, and the process of preparing Chinese medicine object successive dynasties of Pollen Typhae carbon are all on the books." Bencao Congxin: " frying black property puckery, only all blood "; " must join book on Chinese herbal medicine ": " the raw use of promoting the circulation of blood, hemostasis is fried black "." book on Chinese herbal medicine justice ": " want the raw use of profit, wish fries admittedly ".Modern study points out, after Pollen Typhae parch to black due to the adsorption of charcoal element, thereby accelerate hematoblastic setting rate, increase hemostatic function, thereby Pollen Typhae carbon has the only curative effect of all blood clinically.
Charred Radix Et Rhizoma Rhei is a kind of Preparation process product of Chinese herb rhubarb, this product surface coke black, and inner burnt brown, light weight and crisp, feeble QI, mildly bitter flavor, has the effect of hemostasis antidiarrheal, and can be used for large intestine has the stagnant diseases such as stool hematochezia traumatic hemorrhage, to all cards of haematemesis metrorrhagia.Use after Radix Et Rhizoma Rhei parch to black, can reduce the property of its fast profit and bring into play the merit of hemostasis.
In the present invention, various raw material Dou Kecong used market is bought and is obtained, and its specification is that pharmaceutical grade or food stage all can.Hemostatic of traditional herb medicine compositions of the present invention, with Crinis Carbonisatus, Pollen Typhae carbon and three kinds of compatibility of drugss of charred Radix Et Rhizoma Rhei, has fully been applied the premium properties feature of above-mentioned raw materials medicine and the complementary superposition of their performances, and drug effect is remarkable, has the several functions such as hemostasis, granulation promoting, righting.
Preferably, described Hemostatic of traditional herb medicine compositions, composed of the following components according to listed as parts by weight: 6 parts of 10 parts of Crinis Carbonisatus, 10 parts of Pollen Typhae carbon and charred Radix Et Rhizoma Rheis.
Further, described Hemostatic of traditional herb medicine compositions, the preparation method of wherein said Crinis Carbonisatus comprises the following steps:
1) first the impurity that is mixed with in Crinis Carbonisatus is removed, then cleaned Crinis Carbonisatus and remove the grease on Crinis Carbonisatus, then clear water rinses, dry standby;
2) Crinis Carbonisatus drying in step 1) is packed in resistant to elevated temperatures container, by seal of vessel, then described container is heated, be heated to 260-300 ℃, forging 30-60min, stops heating, after container is completely cold, open container, taking-up Crinis Carbonisatus pack in airtight crock, seal standby.Due to the bad assurance of forging time, can on marmite, put scraps of paper that soak, treat scraps of paper flavescence, can stop heating.
Further, described Hemostatic of traditional herb medicine compositions, in the preparation method step 1) of described Crinis Carbonisatus, cleans Crinis Carbonisatus with sodium bicarbonate aqueous solution, removes the grease on Crinis Carbonisatus.For the greasy dirt on hair being cleaned up, conventionally with weak base water, clean, as: sodium bicarbonate (sodium bicarbonate) aqueous solution, the aqueous solution of carbonate, Fructus Gleditsia water etc. all can.
Further, described Hemostatic of traditional herb medicine compositions, the preparation method step 2 of described Crinis Carbonisatus) in, described container is marmite.
Further, described Hemostatic of traditional herb medicine compositions, the preparation method of described Pollen Typhae carbon is: the dry Pollen Typhae pollen cleaning is placed in pot, and 90-130 ℃ is not stopped to stir-fry, extremely described Pollen Typhae pollen is sepia.
Take the dish out of the pot pack in little metal bucket or magnetic shoe tank, seal standby.Pollen Typhae is that quality is soft, the pollen that granule is tiny, even if select little fiery Pollen Tyjphae (parched) charcoal, the dry pollen contacting with pot is also prone to carbonization and the inhomogeneous phenomenon of color and luster, therefore, pot can be burnt to heat to temperature 120-130 ℃, close fire, then Pollen Typhae pollen is placed in pot and stir-fried, like this because the temperature of pot is slowly to decline, more fry temperature lower, Pollen Typhae pollen is not prone to Mars, has reduced " ashing ".
Further, described Hemostatic of traditional herb medicine compositions, the preparation method of described charred Radix Et Rhizoma Rhei is: get the rhubarb tablets of 1-2cm, be placed in heat pot, fry to appearance black for 180～220 ℃, inner burnt brown, spray clear water a little, extinguish Mars, take out, the cool charred Radix Et Rhizoma Rhei that obtains dries in the air.
A thing, composed of the following components according to listed as parts by weight: Crinis Carbonisatus 5-15 part, Pollen Typhae carbon 10-20 part and charred Radix Et Rhizoma Rhei 5-10 part.
The preparation method of described hemostatic for external use thing, mixes the Crinis Carbonisatus of described formula ratio, Pollen Typhae carbon and charred Radix Et Rhizoma Rhei, pulverizes, and crosses 80-120 mesh sieve, obtains powder mixture and is hemostatic for external use thing.This haemostatic medicament all has significant hemostasis and pain-relieving, promoting tissue regeneration by astringents effect to hemorrhage, is applicable to various crowds, and without any discomfort, stable curative effect is reliable, takes orally and also can reach very soon the object of hemostasis.Because being dry powder, can carry, standby in also can family, meet bleeding, clear up wound, after sterilization, described haemostatic medicament is sprinkling upon to wound surface, as larger in wound area, after needing to spread pesticides, with antiseptic gauze parcel, prevent the unrestrained effect that does not have hemostasis of medicine.
The application of Hemostatic of traditional herb medicine compositions of the present invention in preparing haemostatic medicament.
Beneficial effect of the present invention is: Hemostatic of traditional herb medicine composite formula of the present invention is simple, three kinds of material medicine compatibilities have only been chosen, the premium properties feature of crude drug and the complementary superposition of their performances have fully been applied, drug effect is remarkable, there is the several functions such as hemostasis, granulation promoting, righting, reduced cost; The haemostatic medicament of preparing based on said composition, it is easy to use, haemostatic effect good and wound does not infect; And it is simple to operate to utilize said composition to prepare the method for haemostatic medicament, is applicable to suitability for industrialized production.
The specific embodiment
Illustrated embodiment is in order better content of the present invention to be described, but is not that content of the present invention only limits to illustrated embodiment.So those of ordinary skill in the art carry out nonessential improvement and adjustment according to foregoing invention content to embodiment, still belong to protection scope of the present invention.
Embodiment 1 haemostatic medicament
The haemostatic medicament of being prepared by Hemostatic of traditional herb medicine compositions, compositions is composed of the following components according to listed as parts by weight: Crinis Carbonisatus 600g, Pollen Typhae carbon 1500g part and charred Radix Et Rhizoma Rhei 600g.
The preparation method of described Crinis Carbonisatus is:
1) choose shiny black human hair, first the impurity that is mixed with in Crinis Carbonisatus is removed, then with sodium bicarbonate aqueous solution, clean Crinis Carbonisatus and remove the grease on Crinis Carbonisatus, then clear water rinses, dry standby;
2) the above-mentioned Crinis Carbonisatus drying is packed in marmite, by marmite sealing, then described container is heated, be heated to 260 ℃, forging 50min, stops heating, after marmite is cooling, opens marmite taking-up Crinis Carbonisatus standby.
The preparation method of described Pollen Typhae carbon is: the dry Pollen Typhae pollen cleaning is placed in pot, and 90 ℃ are not stopped to stir-fry, and is sepia obtains Pollen Typhae carbon to described Pollen Typhae pollen.
The preparation method of described charred Radix Et Rhizoma Rhei is: Radix Et Rhizoma Rhei is broken into the rhubarb tablets of 1cm, is placed in heat pot, fry to appearance black for 180 ℃, inner burnt brown, spray clear water a little, extinguish Mars, take out, the cool charred Radix Et Rhizoma Rhei that obtains dries in the air.
The Crinis Carbonisatus of described formula ratio, Pollen Typhae carbon and charred Radix Et Rhizoma Rhei are mixed, pulverize, cross 80 mesh sieves, obtain powder mixture, be hemostatic for external use thing, pack in crock, seal standby.
Embodiment 2 haemostatic medicaments
The haemostatic medicament of being prepared by Hemostatic of traditional herb medicine compositions, compositions is composed of the following components according to listed as parts by weight: Crinis Carbonisatus 1000g, Pollen Typhae carbon 1000g part and charred Radix Et Rhizoma Rhei 600g.
The preparation method of described Crinis Carbonisatus is:
1) choose shiny black human hair, the impurity that is mixed with in Crinis Carbonisatus is removed, then with Fructus Gleditsia water cleaning Crinis Carbonisatus, remove the grease on Crinis Carbonisatus, then clear water rinses, dry standby;
2) the above-mentioned Crinis Carbonisatus drying is packed in marmite, by marmite sealing, then described container is heated, be heated to 280 ℃, forging 45min, stops heating, after marmite is cooling, opens marmite taking-up Crinis Carbonisatus standby.
The preparation method of described Pollen Typhae carbon is: the dry Pollen Typhae pollen cleaning is placed in pot, and 100 ℃ are not stopped to stir-fry, and is sepia obtains Pollen Typhae carbon to described Pollen Typhae pollen.
The preparation method of described charred Radix Et Rhizoma Rhei is: Radix Et Rhizoma Rhei is broken into the rhubarb tablets of 1cm, is placed in pot, fry to appearance black for 200 ℃, inner burnt brown, spray clear water a little, extinguish Mars, take out, the cool charred Radix Et Rhizoma Rhei that obtains dries in the air.
The Crinis Carbonisatus of described formula ratio, Pollen Typhae carbon and charred Radix Et Rhizoma Rhei are mixed, pulverize, cross 100 mesh sieves, obtain powder mixture, be hemostatic for external use thing, pack in crock, seal standby.
Embodiment 3 haemostatic medicaments
The haemostatic medicament of being prepared by Hemostatic of traditional herb medicine compositions, compositions is composed of the following components according to listed as parts by weight: Crinis Carbonisatus 1000g, Pollen Typhae carbon 1000g part and charred Radix Et Rhizoma Rhei 1000g.
The preparation method of described Crinis Carbonisatus is:
1) choose shiny black human hair, the impurity that is mixed with in Crinis Carbonisatus is removed, then with sodium bicarbonate aqueous solution, clean Crinis Carbonisatus and remove the grease on Crinis Carbonisatus, then clear water rinses, dry standby;
2) the above-mentioned Crinis Carbonisatus drying is packed in marmite, by marmite sealing, then described container is heated, be heated to 280 ℃, forging 30min, stops heating, after marmite is cooling, opens marmite taking-up Crinis Carbonisatus standby.
The preparation method of described Pollen Typhae carbon is: first pot is burnt to temperature and reach 130 ℃, then little fire, is placed in the dry Pollen Typhae pollen cleaning in pot, does not stop to stir-fry, and is sepia obtains Pollen Typhae carbon to described Pollen Typhae pollen.
The preparation method of described charred Radix Et Rhizoma Rhei is: Radix Et Rhizoma Rhei is broken into the rhubarb tablets of 1cm, is placed in pot, fry to appearance black for 220 ℃, inner burnt brown, spray clear water a little, extinguish Mars, take out, the cool charred Radix Et Rhizoma Rhei that obtains dries in the air.
The Crinis Carbonisatus of described formula ratio, Pollen Typhae carbon and charred Radix Et Rhizoma Rhei are mixed, pulverize, cross 100 mesh sieves, obtain powder mixture, be hemostatic for external use thing, pack in crock, seal standby.
Embodiment 4 haemostatic medicaments
The haemostatic medicament of being prepared by Hemostatic of traditional herb medicine compositions, compositions is composed of the following components according to listed as parts by weight: Crinis Carbonisatus 600g, Pollen Typhae carbon 1500g part and charred Radix Et Rhizoma Rhei 600g.
The preparation method of described Crinis Carbonisatus is:
1) choose shiny black human hair, the impurity that is mixed with in Crinis Carbonisatus is removed, then with sodium bicarbonate aqueous solution, clean Crinis Carbonisatus and remove the grease on Crinis Carbonisatus, then clear water rinses, dry standby;
2) the above-mentioned Crinis Carbonisatus drying is packed in marmite, by marmite sealing, then described container is heated, be heated to 300 ℃, forging 30min, stops heating, after marmite is cooling, opens marmite taking-up Crinis Carbonisatus standby.
The preparation method of described Pollen Typhae carbon is: first pot is burnt to temperature and reach 130 ℃, then turn off fire, the dry Pollen Typhae pollen cleaning is placed in pot, do not stop to stir-fry, be sepia obtain Pollen Typhae carbon to described Pollen Typhae pollen.
The preparation method of described charred Radix Et Rhizoma Rhei is: Radix Et Rhizoma Rhei is broken into the rhubarb tablets of 1cm, is placed in pot, fry to appearance black for 200 ℃, inner burnt brown, spray clear water a little, extinguish Mars, take out, the cool charred Radix Et Rhizoma Rhei that obtains dries in the air.
The Crinis Carbonisatus of described formula ratio, Pollen Typhae carbon and charred Radix Et Rhizoma Rhei are mixed, pulverize, cross 120 mesh sieves, obtain powder mixture, be hemostatic for external use thing, pack in crock, seal standby.
Result of use:
The haemostatic medicament of embodiment 1-4 in the present invention, each is through 100 routine triers' confirmations, and this anthemorrhagic drug therapy wound has significant curative effect, and total effective rate reaches 100%.Matched group is used commercially available YUNNAN BAIYAO haemostatic medicament (powder dosage form).The results are shown in Table 1.
Using method: haemostatic medicament is spread to hemorrhage place, in case of hemorrhage more or wound area is larger, can use hospital gauze wrapping, prevent that medicine from coming off.
Table 1 haemostatic medicament total effects is observed statistical table
Note: cure: wound is smooth, completely healing.Effective: wound incrustation does not come off completely.Effective: wound, without redness, starts incrustation.Invalid: wound is red and swollen, inflammation.
After wound forms, immediately wound surface is cleaned up, use haemostatic medicament of the present invention, hemorrhagely stop, also have obvious analgesic effect simultaneously, after using, wound healing incrustation in 1-2 days, can fully recover for 3-5 days.In addition, all there is not the phenomenon infecting in haemostatic medicament of the present invention in 100 routine trier's use procedures.
Finally explanation is, above embodiment is only unrestricted in order to technical scheme of the present invention to be described, although the present invention is had been described in detail with reference to preferred embodiment, those of ordinary skill in the art is to be understood that, can modify or be equal to replacement technical scheme of the present invention, and not departing from aim and the scope of technical solution of the present invention, it all should be encompassed in the middle of claim scope of the present invention.
Claims (10)
1. a Hemostatic of traditional herb medicine compositions, is characterized in that, composed of the following components according to listed as parts by weight: Crinis Carbonisatus 5-20 part, Pollen Typhae carbon 10-20 part and charred Radix Et Rhizoma Rhei 5-10 part.
2. Hemostatic of traditional herb medicine compositions according to claim 1, is characterized in that, composed of the following components according to listed as parts by weight: 6 parts of 10 parts of Crinis Carbonisatus, 10 parts of Pollen Typhae carbon and charred Radix Et Rhizoma Rheis.
3. Hemostatic of traditional herb medicine compositions according to claim 1, is characterized in that, the preparation method of described Crinis Carbonisatus comprises the following steps:
1) first the impurity that is mixed with in Crinis Carbonisatus is removed, then cleaned Crinis Carbonisatus and remove the grease on Crinis Carbonisatus, then clear water rinses, dry standby;
2) Crinis Carbonisatus drying in step 1) is packed in resistant to elevated temperatures container, by seal of vessel, then described container is heated, be heated to 260-300 ℃, forging 30-60min, stops heating and obtaining Crinis Carbonisatus.
4. Hemostatic of traditional herb medicine compositions according to claim 3, is characterized in that, in the preparation method step 1) of described Crinis Carbonisatus, cleans Crinis Carbonisatus remove the grease on Crinis Carbonisatus with sodium bicarbonate aqueous solution.
5. Hemostatic of traditional herb medicine compositions according to claim 3, is characterized in that, the preparation method step 2 of described Crinis Carbonisatus) in, described container is marmite.
6. Hemostatic of traditional herb medicine compositions according to claim 1, is characterized in that, the preparation method of described Pollen Typhae carbon is: the dry Pollen Typhae pollen cleaning is placed in pot, and 90-130 ℃ is not stopped to stir-fry, and is sepia obtains Pollen Typhae carbon to described Pollen Typhae pollen.
7. Hemostatic of traditional herb medicine compositions according to claim 1, is characterized in that, the preparation method of described charred Radix Et Rhizoma Rhei is: get the rhubarb tablets of 1-2cm, be placed in heat pot, fry to appearance black for 180～220 ℃, inner burnt brown, spray clear water a little, extinguish Mars, take out, the cool charred Radix Et Rhizoma Rhei that obtains dries in the air.
8. a hemostatic for external use thing, is characterized in that, composed of the following components according to listed as parts by weight: Crinis Carbonisatus 5-20 part, Pollen Typhae carbon 10-20 part and charred Radix Et Rhizoma Rhei 5-10 part.
9. the preparation method of hemostatic for external use thing claimed in claim 8, is characterized in that, the Crinis Carbonisatus of described formula ratio, Pollen Typhae carbon and charred Radix Et Rhizoma Rhei are mixed, and pulverizes, and crosses 80-120 mesh sieve, obtains powder mixture and is hemostatic for external use thing.
10. the application of the Hemostatic of traditional herb medicine compositions described in claim 1 or 2 in preparing haemostatic medicament.
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| CN111728983A (en) * | 2019-03-21 | 2020-10-02 | 北京四方中药饮片有限公司 | Crinis carbonisatus and production method thereof |
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Application publication date: 20140115 |