CN103502247B - 7-氮杂吲哚衍生物 - Google Patents

7-氮杂吲哚衍生物 Download PDF

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Publication number
CN103502247B
CN103502247B CN201280007145.3A CN201280007145A CN103502247B CN 103502247 B CN103502247 B CN 103502247B CN 201280007145 A CN201280007145 A CN 201280007145A CN 103502247 B CN103502247 B CN 103502247B
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China
Prior art keywords
compound
pyrrolo
pyridin
mixture
proportions
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Expired - Fee Related
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CN201280007145.3A
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English (en)
Chinese (zh)
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CN103502247A (zh
Inventor
D.多尔施
C.斯伦伯格
T.J.J.米勒
E.梅库
G.卡拉佩特延
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Merck Patent GmbH
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Merck Patent GmbH
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Priority to CN201610048667.8A priority Critical patent/CN105732617B/zh
Priority to CN201610048764.7A priority patent/CN105712991B/zh
Publication of CN103502247A publication Critical patent/CN103502247A/zh
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Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201280007145.3A 2011-02-01 2012-01-09 7-氮杂吲哚衍生物 Expired - Fee Related CN103502247B (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201610048667.8A CN105732617B (zh) 2011-02-01 2012-01-09 7‑氮杂吲哚衍生物
CN201610048764.7A CN105712991B (zh) 2011-02-01 2012-01-09 7‑氮杂吲哚衍生物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102011009961.1 2011-02-01
DE102011009961A DE102011009961A1 (de) 2011-02-01 2011-02-01 7-Azaindolderivate
PCT/EP2012/000067 WO2012104007A2 (de) 2011-02-01 2012-01-09 7-azaindolderivate

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN201610048667.8A Division CN105732617B (zh) 2011-02-01 2012-01-09 7‑氮杂吲哚衍生物
CN201610048764.7A Division CN105712991B (zh) 2011-02-01 2012-01-09 7‑氮杂吲哚衍生物

Publications (2)

Publication Number Publication Date
CN103502247A CN103502247A (zh) 2014-01-08
CN103502247B true CN103502247B (zh) 2016-02-24

Family

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Family Applications (3)

Application Number Title Priority Date Filing Date
CN201280007145.3A Expired - Fee Related CN103502247B (zh) 2011-02-01 2012-01-09 7-氮杂吲哚衍生物
CN201610048667.8A Expired - Fee Related CN105732617B (zh) 2011-02-01 2012-01-09 7‑氮杂吲哚衍生物
CN201610048764.7A Expired - Fee Related CN105712991B (zh) 2011-02-01 2012-01-09 7‑氮杂吲哚衍生物

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN201610048667.8A Expired - Fee Related CN105732617B (zh) 2011-02-01 2012-01-09 7‑氮杂吲哚衍生物
CN201610048764.7A Expired - Fee Related CN105712991B (zh) 2011-02-01 2012-01-09 7‑氮杂吲哚衍生物

Country Status (18)

Country Link
US (3) US8981101B2 (OSRAM)
EP (3) EP2746281B1 (OSRAM)
JP (1) JP5891249B2 (OSRAM)
KR (1) KR20140014158A (OSRAM)
CN (3) CN103502247B (OSRAM)
AR (1) AR085110A1 (OSRAM)
AU (1) AU2012213775B2 (OSRAM)
BR (1) BR112013019028A2 (OSRAM)
CA (2) CA2826051C (OSRAM)
DE (1) DE102011009961A1 (OSRAM)
EA (1) EA201300873A1 (OSRAM)
ES (3) ES2634643T3 (OSRAM)
HK (1) HK1226394A1 (OSRAM)
IL (1) IL227689A0 (OSRAM)
MX (1) MX2013008212A (OSRAM)
SG (1) SG192133A1 (OSRAM)
WO (1) WO2012104007A2 (OSRAM)
ZA (1) ZA201306542B (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110461841B (zh) * 2017-06-19 2020-09-15 上海和誉生物医药科技有限公司 一种具有csf1r抑制活性的氮杂芳基衍生物、其制备方法和应用

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US20140303121A1 (en) 2013-03-15 2014-10-09 Plexxikon Inc. Heterocyclic compounds and uses thereof
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JP2021527125A (ja) * 2018-06-07 2021-10-11 ディサーム・セラピューティクス・インコーポレイテッドＤｉｓａｒｍ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． Ｓａｒｍ１阻害剤
KR20200046680A (ko) * 2018-10-25 2020-05-07 한국과학기술원 Pdk1 저해제를 포함하는 역노화 유도용 조성물
WO2025016273A1 (zh) * 2023-07-14 2025-01-23 拜西欧斯（北京）生物技术有限公司 异喹啉衍生物、包含其的药物组合物以及它们的用途

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110461841B (zh) * 2017-06-19 2020-09-15 上海和誉生物医药科技有限公司 一种具有csf1r抑制活性的氮杂芳基衍生物、其制备方法和应用

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AU2012213775A1 (en) 2013-09-19
US20150152104A1 (en) 2015-06-04
CN103502247A (zh) 2014-01-08
JP5891249B2 (ja) 2016-03-22
DE102011009961A1 (de) 2012-08-02
EP3133074A2 (de) 2017-02-22
IL227689A0 (en) 2013-11-25
ES2608317T3 (es) 2017-04-07
EP2746281A3 (de) 2014-10-08
JP2014509313A (ja) 2014-04-17
EP2670748A2 (de) 2013-12-11
EP2670748B1 (de) 2016-09-28
SG192133A1 (en) 2013-08-30
EP2746281B1 (de) 2017-04-26
US8981101B2 (en) 2015-03-17
HK1226394A1 (zh) 2017-09-29
BR112013019028A2 (pt) 2016-10-04
EP3133074B1 (de) 2020-12-09
CN105712991B (zh) 2017-12-01
KR20140014158A (ko) 2014-02-05
CA3082435A1 (en) 2012-08-09
CA2826051A1 (en) 2012-08-09
CN105732617A (zh) 2016-07-06
AR085110A1 (es) 2013-09-11
ES2861048T3 (es) 2021-10-05
CN105732617B (zh) 2017-12-01
AU2012213775B2 (en) 2016-11-10
WO2012104007A2 (de) 2012-08-09
US9725446B2 (en) 2017-08-08
CN105712991A (zh) 2016-06-29
EP3133074A3 (de) 2017-05-17
ES2634643T3 (es) 2017-09-28
US9266887B2 (en) 2016-02-23
AU2012213775A8 (en) 2013-10-24
EA201300873A1 (ru) 2014-02-28
CA2826051C (en) 2020-08-18
US20160130269A1 (en) 2016-05-12
US20130310391A1 (en) 2013-11-21
EP2746281A2 (de) 2014-06-25
WO2012104007A3 (de) 2013-10-17
MX2013008212A (es) 2013-08-26
ZA201306542B (en) 2014-05-28

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