CN103495071B - Capsule for treating neurosis intestinal obstruction after gastrointestinal surgery and preparation method thereof - Google Patents
Capsule for treating neurosis intestinal obstruction after gastrointestinal surgery and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a capsule for treating neurosis intestinal obstruction after gastrointestinal surgery and a preparation method thereof, and aims to solve the problem of treatment of the neurosis intestinal obstruction after abdominal surgery. The capsule is characterized in that the preparation methods includes (1), performing water vapor distillation on gastrodia elata BI, alyxia sinensis and barks or roots of litterflower stringbush to extract volatile oil for standby application, and leaving herb residues for standby application; (2), smashing gecko and burnt rice sprouts into fine powder for standby application; (3), uniformly mixing aspongopus, timonius arboreus, jasminum grandiflorum, allium victorialis, ternate buttercup roots, Chinese starjasmine stems and cassia twigs with the herb residues obtained in step 1, performing alcohol extraction for twice, merging alcohol extracts for twice, filtering, recovering alcohol and performing decompression concentration to form extractum; (4), adding the fine powder obtained in step 2 in the extractum obtained in step 3, mixing well, drying at 60 DEG C, smashing into fine powder, adding polysorbate-80 to form particles, drying, granulating, spraying the volatile oil obtained in step 1, mixing well, and filling to obtain the capsule. Clinical tests show that the capsule has advantages of good treatment effect and high safety and is worthy of clinical application and popularization.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to one and treat neurogenic intestinal obstruction after gastrointestinal surgery capsule and preparation method thereof.
Background technology
Cherchevski's (Neurosis Intestinal Obstruction) is divided into paralytic Cherchevski's and spastic Cherchevski's according to symptom, its pathogenic factor is that abdominal cavity stimulates more, paralytic ileus is more common in acute diffuse peritonitis, retroperitoneal hamorrhage or after infecting because intestinal wall muscular movement is suppressed and lose wriggling ability, intestinal lumen contents can not run downwards; And spastic normal owing to having wound or inflammation inside and outside enteric cavity, foreign bodies etc. stimulate and cause intestinal wall muscle and split contraction by force.Abdominal operation is then common abdominal cavity stimulating factor.
Cherchevski's is different from common mechanical intestinal obstruction, and the former only has ileac sings and symptoms, but mechanical blocks evidence.
Due to the many paralysis of Cherchevski's performance and spasm alternately outbreak, so there is no effective treatment means clinically now, only there is the postoperative generation that can reduce intestinal adhesion at intraperitoneal placement carboxymethyl cellulose (Sodium carboxymethyl cellulose) and oral vitamin E of report.
The traditional Chinese medical science is many to be recorded without primary disease, and treatment is many to be controlled from symptom opinion, but due to the alternately outbreak of Cherchevski's paralysis and spasm, symptom is unstable, thus treat very passive.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly and the preparation method of the little treatment abdominal postoperative Cherchevski's pharmaceutical composition of side effect.
The technical scheme that the present invention solves its technical problem is: a kind of pharmaceutical composition for the treatment of abdominal postoperative Cherchevski's, it is characterized in that being prepared from by the crude drug of following weight proportion: Aspongopus 10 ~ 30 parts, Herba Alyxiae Sinensis 6 ~ 12 parts, alizarin 3 ~ 10 parts of sea, Flos jasmini 6 ~ 12 parts, Cortex Seu Radix Wikstroemiae Micranthae 3 ~ 10 parts, Bulbus Allii Victorialis 6 ~ 12 parts, go back 6 ~ 12 parts, bobbin, Radix Ranunculi Ternati 6 ~ 12 parts, Caulis Trachelospermi 6 ~ 12 parts, Gecko 1 ~ 5 part, Ramulus Cinnamomi 3 ~ 10 parts, Fructus Setariae Germinatus (parched to brown) 10 ~ 25 parts.
Chinese medicine of the present invention can be prepared from by following method:
(1) bobbin will be gone back, Herba Alyxiae Sinensis, Cortex Seu Radix Wikstroemiae Micranthae coarse powder soak separately after 4 hours and extract volatile oil 6 hours with vapor distillation, and mixing for standby use after collecting, medicinal residues are for subsequent use;
(2) Gecko, Fructus Setariae Germinatus (parched to brown) are pulverized 150 mesh sieves, and become fine powder for subsequent use;
(3) by gained medicinal residues mixing in Aspongopus, Hai Qian, Flos jasmini, Bulbus Allii Victorialis, Radix Ranunculi Ternati, Caulis Trachelospermi, Ramulus Cinnamomi and step 1 with 5 times amount 80% ethanol extraction 2 times, each 2 hours, merge twice ethanol extract, filter, reclaiming relative density when ethanol concentrating under reduced pressure become 60 DEG C is the extractum of 1.25 ~ 1.30;
(4) gained fine powder in step 2 is added gained extractum mixing in step 3,60 DEG C of oven dry, are ground into fine powder, add Tween-80 and make granule, and dry, granulate, sprays into gained volatile oil in step 1, and mixing, incapsulates, to obtain final product.
Wherein said: Aspongopus is the dry body of Pentatomidae Insects Aspongopus Aspongopus chinensis Dallas.Nature and flavor are salty, temperature.Return liver,spleen,kidney warp.Merit can regulating QI to relieve pain, and warming middle-JIAO is supporing yang.
Herba Alyxiae Sinensis is herb and the root of apocynaceae plant chain pearl rattan.Toil, flat.Enter lung, liver, spleen three warp.Merit can expelling wind and removing dampness, promoting blood circulation to remove obstruction in the collateral.
Hai Qian is Sargassaceae plant Alga Sgrgassi Enerves Sargassum enerve C.Ag., Sargassum henslowianum Sargassum henslowianum C.Ag., sargassum thunbergii Sargassum thunbergii(Mert.) O.Kuntze or Sargassum phyllocystum Tseng et Lu,Sargassum horneri (Turn.) C. Ag. (Fucus horneri (Turn.)C.Ag.,Spongocarpus horneri Kutz.) argassum horneri(Turn.) frond of C. Ag.Nature and flavor are salty; Cold.Return liver; Stomach; Kidney channel.Merit can hard masses softening and resolving; Removing heat-phlegm.
Flos jasmini is Oleaceae plants Flos jasmini Jasminu, the dry flower of grandiflorum L..Property mildly bitter flavor; Property is put down.Return Liver Channel.Merit can soothing liver-QI for relieving depression, promoting the circulation of QI to relieve pain.
Cortex Seu Radix Wikstroemiae Micranthae is peel of stem and the root of Isolated From Thymelaeaceae Species little Huang structure Wikstroemia micrantha Hemsl..Sweet in the mouth; Property is put down.Return lung meridian.Merit can relieving cough and resolving phlegm; Heat reliving and toxin-eliminating.
Bulbus Allii Victorialis is the bulb of liliaceous plant Bulbus Allii Victorialis Allium victorialis L..Return lung meridian.Merit can dissipating blood stasis; Hemostasis; Removing toxic substances.
Also bobbin is the fruit of orchid Rhizoma Gastrodiae Gastrodia elata Bl..Sweet in the mouth; Cold in nature.Merit can tonify deficiency subduing the wind syndrome.
Radix Ranunculi Ternati is the dried root of ranunculaceae plant Seynuns Kugelann Ranunculus ternatus Thunb..Nature and flavor sweet, acrid, warm.Return liver, lung meridian.Merit can eliminating stagnation, detumescence.
Caulis Trachelospermi is the dry zone leaf rattan of apocynaceae plant trachelospermum jasminoide Trachelospermum jasminoides (Lindl.) Lem..Hardship, is slightly cold.Return kidney, liver, kidney channel.Merit can dispelling wind and removing obstruction in the collateral, and removing heat from blood is subsided a swelling.
Gecko is the dry body of Gekkonidae animal Gecko Gekko gecko Linnaeus.Nature and flavor are salty, flat.Return lung, kidney channel.Merit can invigorating the lung and the kidney, improving inspiration by invigorating kidney-QI Dingchuan, supporing yang benefit essence.
Ramulus Cinnamomi is the withe of canella Cortex Cinnamomi Cinnamomum cassia Presl.Nature and flavor acrid, sweet, warm.Enter the heart, lung, urinary bladder channel.Merit can relieving the exterior syndrome by diaphoresis, promoting the flow of QI-blood by warming the meridian, activating YANG and prormoting functioning of QI.
Fructus Setariae Germinatus (parched to brown), for the mature fruit of grass foxtail millet Setaria italica (L.) Beauv. is through drying of germinateing, fries to burnt brown according to frying method.Nature and flavor are sweet, temperature.Return spleen, stomach warp.Merit can help digestion and in, spleen benefiting and stimulating the appetite.
Compared with prior art, the present invention has following characteristics.
1, set forth one's views unique: start with from dredging collateral, to recover for the purpose of intestinal wall CO2 laser weld, avoid using purgatives medicine thing, although because purgatives medicine thing can solve abdominal distention for the moment, cause again new stimulation to intestinal wall, for a long time raw he become, protracted course of disease.
2, with Aspongopus, Herba Alyxiae Sinensis for monarch: inventor's clinical experience gained, Cherchevski's is a kind of reflexive performance after art midgut wall nerve is upset, and Aspongopus regulating QI to relieve pain, Herba Alyxiae Sinensis promoting blood circulation to remove obstruction in the collateral, can reduce this zest and reflect the untoward reaction brought to intestinal.Basic pharmacology test confirms: Partial small bowel obstruction rat model Aspongopus (20g crude drug/kg/d) and Herba Alyxiae Sinensis (10g crude drug/kg/d) mixing water decocting liquid gavage, can intestinal mucosa injury be reduced, to incomplete intestinal obstruction Intestinal Mucosa, there is protective effect; And the progradation of rat intestine wriggling is observed by charcoal end method, propelling rate (84.42 ± 13.24) % of Aspongopus, Herba Alyxiae Sinensis drug combination group is apparently higher than blank group of (59.33 ± 15.62) %.
3, using sea, alizarin hard masses softening and resolving, Cortex Seu Radix Wikstroemiae Micranthae digestion visible phlegm, Caulis Trachelospermi dispelling wind dredging collateral, Flos jasmini promoting the circulation of QI to relieve pain, Bulbus Allii Victorialis dissipating blood stasis, Radix Ranunculi Ternati mass dissipating and swelling eliminating assist monarch drug as ministerial drug: breath does not reach, of a specified duration then can block by accumulation of phlegm, so select Cortex Seu Radix Wikstroemiae Micranthae, the alizarin visible phlegm removed in intestinal venation in sea, the ability of Flos jasmini, Caulis Trachelospermi, Radix Ranunculi Ternati increase medicine walking venation.Bulbus Allii Victorialis has the advantages that dissipating blood stasis does not consume gas, is particularly suitable for abdominal postoperative simulataneous insufficiency and excessive and uses.
4, with Gecko invigorating the lung and the kidney, go back the righting of bobbin tonify deficiency subduing the wind syndrome, wherein the aminoacid that contains of Gecko and phospholipid composition can reduce the content of malonaldehyde in cell membrane (MDA), play the effect of stable intestinal cell cell membrane.
5, low dose of Ramulus Cinnamomi is corrigent, resist the anxiety that this prescription invasion by pathogenic cold medicine of a cold nature thing too much has consumption impairment of QI the moon, and the effect of its activating YANG and prormoting functioning of QI is also echoed with Aspongopus, contributes to row loose.
6, Fructus Setariae Germinatus (parched to brown) is sweet in flavor and warm in property, returns taste warp, get protect sun defend in meaning, and contained coking composition has astriction, has the meaning of receipts in loose.
7, the homogeneous medicine multiple-effect of institute's thing of getting it filled in side, contributes to reducing medicament categories and consumption, does not increase Liver and kidney burden.
8, medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, and each raw material dosage is for all to have good curative effect in following weight parts scope.
9, adopt capsule formulation, taking convenience, compliance is good, is convenient to the consolidation of the course for the treatment of.
Detailed description of the invention
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: Aspongopus 20 parts, Herba Alyxiae Sinensis 10 parts, alizarin 6 parts of sea, Flos jasmini 10 parts, Cortex Seu Radix Wikstroemiae Micranthae 6 parts, Bulbus Allii Victorialis 10 parts, go back 10 parts, bobbin, Radix Ranunculi Ternati 10 parts, Caulis Trachelospermi 10 parts, Gecko 2 parts, Ramulus Cinnamomi 6 parts, Fructus Setariae Germinatus (parched to brown) 20 parts.
The preparation method of embodiment 1 is: by Aspongopus, Herba Alyxiae Sinensis, Hai Qian, Flos jasmini, Cortex Seu Radix Wikstroemiae Micranthae, Bulbus Allii Victorialis, go back bobbin, Radix Ranunculi Ternati, Caulis Trachelospermi, Gecko, Ramulus Cinnamomi, the decoction of Fructus Setariae Germinatus (parched to brown) mixing and water adding, filtrate is got after 30 minutes, medicinal residues add water continue decoction get filtrate after 20 minutes, twice filtrate merges, and is divided into two parts of morning and evenings to take.
Embodiment 2, crude drug weight proportion: Aspongopus 10 parts, Herba Alyxiae Sinensis 6 parts, alizarin 3 parts of sea, Flos jasmini 6 parts, Cortex Seu Radix Wikstroemiae Micranthae 3 parts, Bulbus Allii Victorialis 6 parts, go back 6 parts, bobbin, Radix Ranunculi Ternati 6 parts, Caulis Trachelospermi 6 parts, Gecko 1 part, Ramulus Cinnamomi 3 parts, Fructus Setariae Germinatus (parched to brown) 10 parts.
Embodiment 3, crude drug weight proportion: Aspongopus 20 parts, Herba Alyxiae Sinensis 10 parts, alizarin 6 parts of sea, Flos jasmini 10 parts, Cortex Seu Radix Wikstroemiae Micranthae 6 parts, Bulbus Allii Victorialis 10 parts, go back 10 parts, bobbin, Radix Ranunculi Ternati 10 parts, Caulis Trachelospermi 10 parts, Gecko 2 parts, Ramulus Cinnamomi 6 parts, Fructus Setariae Germinatus (parched to brown) 20 parts.
Embodiment 4, crude drug weight proportion: Aspongopus 30 parts, Herba Alyxiae Sinensis 12 parts, alizarin 10 parts of sea, Flos jasmini 12 parts, Cortex Seu Radix Wikstroemiae Micranthae 10 parts, Bulbus Allii Victorialis 12 parts, go back 12 parts, bobbin, Radix Ranunculi Ternati 12 parts, Caulis Trachelospermi 12 parts, Gecko 5 parts, Ramulus Cinnamomi 10 parts, Fructus Setariae Germinatus (parched to brown) 25 parts.
The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:
(1) bobbin will be gone back, Herba Alyxiae Sinensis, Cortex Seu Radix Wikstroemiae Micranthae coarse powder soak separately after 4 hours and extract volatile oil 6 hours with vapor distillation, and mixing for standby use after collecting, medicinal residues are for subsequent use;
(2) Gecko, Fructus Setariae Germinatus (parched to brown) are pulverized 150 mesh sieves, and become fine powder for subsequent use;
(3) by gained medicinal residues mixing in Aspongopus, Hai Qian, Flos jasmini, Bulbus Allii Victorialis, Radix Ranunculi Ternati, Caulis Trachelospermi, Ramulus Cinnamomi and step 1 with 5 times amount 80% ethanol extraction 2 times, each 2 hours, merge twice ethanol extract, filter, reclaiming relative density when ethanol concentrating under reduced pressure become 60 DEG C is the extractum of 1.25 ~ 1.30;
(4) gained fine powder in step 2 is added gained extractum mixing in step 3,60 DEG C of oven dry, are ground into fine powder, add Tween-80 and make granule, and dry, granulate, sprays into gained volatile oil in step 1, and mixing, incapsulates, to obtain final product.
Can set every capsules is 0.5g.
The efficient combination of said medicine, coordinates mutually, effectively reach the object for the treatment of abdominal postoperative Cherchevski's, and side effect is less.The above results is clinical data sufficient proof, and interrelated data is as follows.
1 object and method.
1.1 object.
1.1.1 case selection: case is selected from case 70 example that in June, 2010 ~ 2013 are diagnosed as Cherchevski's year June.All cases are abdominal surgery postoperative patient.
1.1.2 Cherchevski's diagnostic criteria: (1) suffers from abdominal pain: paroxysmal abdominal pain; (2) vomit: high obstruction vomiting is comparatively frequent, it is less that low level blocks vomiting number of times, and vomitus is smelly with excrement; (3) abdominal distention: low level blocks full abdominal distention, often accompanies visible peristalsis visible intestinal peristalsis, high obstruction abdominal distention is not obvious; (4) aerofluxus and defecation stop; (5) sign: the intestinal tube of expansion has tenderness, rebound tenderness; Borborygmus is faint or disappear or gur gling; (6) x-ray diagnosis intestinal blocks important value.And get rid of mechanical intestinal obstruction.
1.1.3 three groups are divided at random: matched group 25 example, decoction group 23 example, Capsules group 22 example.Compare in sex, age, art formula before three groups of patient treatments, no significant difference (P>0.05), has comparability.
1.2 method.
1.2.1 Therapeutic Method: matched group takes gastrointestinal decompression, fluid infusion, correction acid base imbalance, anti-infective therapy, decoction group adds with embodiment 1 gained decoction on matched group medication basis, 2 times/d; Capsules group adds described embodiment 3 gained capsule 2g/ time on matched group medication basis, 2 times/d, altogether 5d.
1.2.2 judge according to criterion of therapeutical effect ileac in " new Chinese medicine guideline of clinical investigations ".Recovery from illness: Clinical symptom and sign disappears, normal passage of gas by anus defecation, borborygmus recovers, and X-ray of abdomen intestinal tube inflatable dilatation disappears, and can pull out gastrointestinal decompression tube.Effective: Clinical symptom and sign obviously alleviates, borborygmus recovers substantially, and X-ray of abdomen intestinal tube inflatable dilatation obviously alleviates, and can close gastrointestinal decompression tube and observe.Effective: abdominal part distending pain alleviates to some extent, aerofluxus, defecation are not smooth, and abdominal part auscultation borborygmus is weak, and X-ray of abdomen intestinal tube inflatable dilatation alleviates, and still needs indwelling gastrointestinal decompression tube.Invalid: still without aerofluxus, defecation after medication 72 h, Clinical symptom and sign is without alleviation or increase the weight of.
1.2.3 statistical analysis: SPSS 13.0 carries out statistical analysis.Measurement data t checks, enumeration data χ
2inspection.
2 results.
2.1 3 groups of Clinical efficacy comparisons: see the following form.Result shows: the cure rate of decoction group and Capsules group is apparently higher than matched group (decoction group P<0.01; Capsules group P<0.05); Total effective rate is apparently higher than matched group (P<0.05).
| Group | Number of cases | Recovery from illness | Effective | Effectively | Invalid | Total effective rate |
| Matched group | 25 | 2（8.00%） | 9（36.00%） | 7（28.00%） | 7（28.00%） | 72.00% |
| Decoction group | 23 | 12（52.17%） | 7（30.43%） | 3（13.04%） | 1（4.35%） | 95.65% |
| Capsules group | 22 | 5（22.73%） | 11（50.00%） | 4（18.18%） | 2（9.09%） | 90.91% |
Relapse rate in 2.2 3 groups of patient half days: the effective patient for the treatment of of control group had 22.22%(4/18 in three months) patient there is recurrence, decoction group is 4.55%(1/22), Capsules group is 5.00%(1/20), the relapse rate of decoction group and Capsules group is starkly lower than matched group (P<0.01).
2.3 3 groups of adverse reactions of patients incidence rates compare: three groups all do not occur obvious adverse reaction record.
3. conclusion.
This result of study shows, after taking decoction of the present invention or capsule, abdominal postoperative Cherchevski's patient cure rate, total effective rate are apparently higher than matched group, and relapse rate is starkly lower than matched group, there is not obvious adverse reaction record, illustrate that pharmaceutical composition prepared by the inventive method has the lighter advantage of good effect, untoward reaction in treatment abdominal postoperative Cherchevski's.
Claims (1)
1. treat the preparation method of neurogenic intestinal obstruction after gastrointestinal surgery capsule for one kind, it is characterized in that: be prepared from by the crude drug of following weight proportion: Aspongopus 10 ~ 30 parts, Herba Alyxiae Sinensis 6 ~ 12 parts, alizarin 3 ~ 10 parts of sea, Flos jasmini 6 ~ 12 parts, Cortex Seu Radix Wikstroemiae Micranthae 3 ~ 10 parts, Bulbus Allii Victorialis 6 ~ 12 parts, go back 6 ~ 12 parts, bobbin, Radix Ranunculi Ternati 6 ~ 12 parts, Caulis Trachelospermi 6 ~ 12 parts, Gecko 1 ~ 5 part, Ramulus Cinnamomi 3 ~ 10 parts, Fructus Setariae Germinatus (parched to brown) 10 ~ 25 parts, be made up of following steps:
(1) bobbin will be gone back, Herba Alyxiae Sinensis, Cortex Seu Radix Wikstroemiae Micranthae coarse powder soak separately after 4 hours and extract volatile oil 6 hours with vapor distillation, and mixing for standby use after collecting, medicinal residues are for subsequent use;
(2) Gecko, Fructus Setariae Germinatus (parched to brown) are pulverized 150 mesh sieves, and become fine powder for subsequent use;
(3) by gained medicinal residues mixing in Aspongopus, Hai Qian, Flos jasmini, Bulbus Allii Victorialis, Radix Ranunculi Ternati, Caulis Trachelospermi, Ramulus Cinnamomi and step 1 with 5 times amount 80% ethanol extraction 2 times, each 2 hours, merge twice ethanol extract, filter, reclaiming relative density when ethanol concentrating under reduced pressure become 60 DEG C is the extractum of 1.25 ~ 1.30;
(4) gained fine powder in step 2 is added gained extractum mixing in step 3,60 DEG C of oven dry, are ground into fine powder, add Tween-80 and make granule, and dry, granulate, sprays into gained volatile oil in step 1, and mixing, incapsulates, to obtain final product.
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| CN201510193007.4A CN104771635A (en) | 2013-10-17 | 2013-10-17 | Preparation method of medicine for treating neural intestinal obstruction after abdominal external operation |
| CN201310486091.XA CN103495071B (en) | 2013-10-17 | 2013-10-17 | Capsule for treating neurosis intestinal obstruction after gastrointestinal surgery and preparation method thereof |
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| CN201310486091.XA CN103495071B (en) | 2013-10-17 | 2013-10-17 | Capsule for treating neurosis intestinal obstruction after gastrointestinal surgery and preparation method thereof |
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| CN201510193007.4A Pending CN104771635A (en) | 2013-10-17 | 2013-10-17 | Preparation method of medicine for treating neural intestinal obstruction after abdominal external operation |
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| CN105797137B (en) * | 2016-06-02 | 2020-06-19 | 张希芳 | Compound nursing preparation for treating neurosis intestinal obstruction after abdominal operation and preparation method thereof |
| CN106310224A (en) * | 2016-08-31 | 2017-01-11 | 王蕾 | Compound nursing preparation for treating nervous intestinal obstruction after abdominal operation and preparation method of compound nursing preparation |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1101857A (en) * | 1993-10-22 | 1995-04-26 | 杜军强 | Chinese-medicinal imaging assistant to stomach for ultrasonography B and preparing process |
| CN1429603A (en) * | 2002-12-02 | 2003-07-16 | 张方平 | Medicine for treating stomach disease |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070160689A1 (en) * | 2006-01-12 | 2007-07-12 | Everett Laboratories, Inc. | Compositions and methods for treatment of coughing, sneezing, rhinorrhea, and/or nasal obstruction |
| CN102335311B (en) * | 2011-10-20 | 2012-11-28 | 朱剑萍 | Decoction for treating intestinal obstruction, and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1101857A (en) * | 1993-10-22 | 1995-04-26 | 杜军强 | Chinese-medicinal imaging assistant to stomach for ultrasonography B and preparing process |
| CN1429603A (en) * | 2002-12-02 | 2003-07-16 | 张方平 | Medicine for treating stomach disease |
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Inventor after: Liu Chengcong Inventor after: Zhang Lin Inventor after: Chen Ruiyun Inventor after: Cheng Renjun Inventor before: Han Guangming Inventor before: Zhang Yanyan Inventor before: Liu Jiaxiu Inventor before: Cheng Renjun |
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Free format text: CORRECT: INVENTOR; FROM: HAN GUANGMING ZHANG YANYAN LIU JIAXIU CHENG RENJUN TO: LIU CHENGCONG ZHANG LIN CHEN RUIYUN CHENG RENJUN |
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Effective date of registration: 20150616 Address after: 127 Qingdao Central Hospital, four South Stream Road, Shandong, Qingdao 266042, China Applicant after: Zhongxin Hospital, Qingdao Address before: 276826 Rizhao City traditional Chinese medicine hospital, 35 Hai Lu, Shandong, Rizhao City Applicant before: Han Guangming |
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