CN103495070B - Navel-applied agent for treating bowel dysfunction after abdominal surgery - Google Patents
Navel-applied agent for treating bowel dysfunction after abdominal surgery Download PDFInfo
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- CN103495070B CN103495070B CN201310486089.2A CN201310486089A CN103495070B CN 103495070 B CN103495070 B CN 103495070B CN 201310486089 A CN201310486089 A CN 201310486089A CN 103495070 B CN103495070 B CN 103495070B
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Abstract
The invention discloses a pharmaceutical composition for treating bowel dysfunction after an abdominal surgery in order to solve the treatment problem of the bowel dysfunction after the abdominal surgery. The navel-applied agent is characterized by comprising raw materials including, by weight, aspongopus chinensis dallas, alyxia, timonius arboreus, jasminum grandiflorum, caryopteris terniflora maxim, allium victorialis, gastrodia elata bl, spatholobus suberectus dunn, securinega suffruticosa, azurite, cinnamomum cassia presl and setaria italica beauv. Clinical trials prove that the pharmaceutical composition has the advantages of good curative effect on bowel dysfunction, high security, and being worthy of clinical application and promotion.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of deposited umbilicus agent for the treatment of abdominal postoperative bowel dysfunction.
Background technology
Bowel dysfunction, is one group and comprises and continuing or interval outbreak, and to suffer from abdominal pain, abdominal distention, bowl evacuation habit and stool are abnormal is the bowel dysfunction disease of clinical manifestation.The bowel dysfunction that abdominal postoperative occurs is divided into paralytic disorder and spastic disorder according to symptom, acute diffuse peritonitis is more common in paralytic disorder, retroperitoneal hamorrhage or after infecting because intestinal wall muscular movement is suppressed and lose wriggling ability, intestinal lumen contents can not run downwards; And spastic disorder is often owing to having wound or inflammation inside and outside enteric cavity, foreign body etc. stimulate and cause intestinal wall muscle and split contraction by force.
The bowel dysfunction that abdominal postoperative occurs is different from intestinal neurosis, the latter is also known as irritable bowel syndrome, be that individual body constitution accounts for leading a kind of disease, the bowel dysfunction that abdominal postoperative occurs is then clearly relevant to abdominal operation, clearly relevant to intestinal environmental stimuli.
The many paralysis of bowel dysfunction performance occurred due to abdominal postoperative and spasm alternately outbreak, so there is no effective treatment means clinically now, only there is the postoperative generation that can reduce intestinal adhesion at intraperitoneal placement carboxymethyl cellulose (Sodium carboxymethyl cellulose) and oral vitamin E of report.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly and the deposited umbilicus agent of the little treatment abdominal postoperative bowel dysfunction of side effect.
The technical scheme that the present invention solves its technical problem is: a kind of deposited umbilicus agent for the treatment of abdominal postoperative bowel dysfunction, is characterized in that being prepared from by the crude drug of following weight proportion: Aspongopus 10 ~ 30 parts, Herba Alyxiae Sinensis 6 ~ 12 parts, alizarin 3 ~ 10 parts of sea, Flos jasmini 6 ~ 12 parts, Herba Caryopteridis Terniflorae 3 ~ 10 parts, Bulbus Allii Victorialis 6 ~ 12 parts, go back 6 ~ 12 parts, bobbin, nine layers of wind 6 ~ 12 parts, Cacumen Securinegae Suffruticosae 6 ~ 12 parts, Azuritum 1 ~ 5 part, Ramulus Cinnamomi 3 ~ 10 parts, Fructus Setariae Germinatus (parched to brown) 10 ~ 25 parts.
Chinese medicine of the present invention is prepared from by the raw material of following optimum weight part proportioning: Aspongopus 20 parts, Herba Alyxiae Sinensis 10 parts, alizarin 6 parts of sea, Flos jasmini 10 parts, Herba Caryopteridis Terniflorae 6 parts, Bulbus Allii Victorialis 10 parts, go back 10 parts, bobbin, nine layers of wind 10 parts, Cacumen Securinegae Suffruticosae 10 parts, Azuritum 2 parts, Ramulus Cinnamomi 6 parts, Fructus Setariae Germinatus (parched to brown) 20 parts.
Wherein said: Aspongopus is the dry body of Pentatomidae Insects Aspongopus Aspongopus chinensis Dallas.Nature and flavor are salty, temperature.Return liver,spleen,kidney warp.Merit can regulating QI to relieve pain, and warming middle-JIAO is supporing yang.
Herba Alyxiae Sinensis is herb and the root of apocynaceae plant chain pearl rattan.Toil, flat.Enter lung, liver, spleen three warp.Merit can expelling wind and removing dampness, promoting blood circulation to remove obstruction in the collateral.
Hai Qian is Sargassaceae plant Alga Sgrgassi Enerves Sargassum enerve C.Ag., Sargassum henslowianum Sargassum henslowianum C.Ag., sargassum thunbergii Sargassum thunbergii(Mert.) O.Kuntze or Sargassum phyllocystum Tseng et Lu,Sargassum horneri (Turn.) C. Ag. (Fucus horneri (Turn.)C.Ag.,Spongocarpus horneri Kutz.) argassum horneri(Turn.) frond of C. Ag.Nature and flavor are salty; Cold.Return liver; Stomach; Kidney channel.Merit can hard masses softening and resolving; Removing heat-phlegm.
Flos jasmini is Oleaceae plants Flos jasmini Jasminu, the dry flower of grandiflorum L..Property mildly bitter flavor; Property is put down.Return Liver Channel.Merit can soothing liver-QI for relieving depression, promoting the circulation of QI to relieve pain.
Herba Caryopteridis Terniflorae is Verenaceae Caryopteris plants three flower Herba caryopteridis nepetaefoliae Caryopteris terniflora Maxim., with all herbal medicine.The pungent micro-hardship of nature and flavor; Flat.Return lung meridian.Merit can dispelling wind to relieve the exterior syndrome; Lung qi dispersing cough-relieving.
Bulbus Allii Victorialis is the bulb of liliaceous plant Bulbus Allii Victorialis Allium victorialis L..Return lung meridian.Merit can dissipating blood stasis; Hemostasis; Removing toxic substances.
Also bobbin is the fruit of orchid Rhizoma Gastrodiae Gastrodia elata Bl..Sweet in the mouth; Cold in nature.Merit can tonify deficiency subduing the wind syndrome.
Nine layers of wind are the dry rattan of leguminous plant spatholobus suberectus Spatholobus suberectus Dunn.Nature and flavor are bitter, sweet, temperature.Return liver, kidney channel.Merit can be enriched blood, and invigorates blood circulation, dredging collateral.
Cacumen Securinegae Suffruticosae is euphorbia plant Suffrutescent Securinega Twig Securinega suffruticosa(Pal1.) browse of Rehd. or root.Acrid in the mouth; Bitter; Slightly warm in nature.Return liver; Kidney; Spleen channel.Merit can expelling wind and activating blood circulation; The strong muscle of kidney tonifying.
Azuritum is the Ore of carbonate mineral chessy copper Azurite.Nature and flavor acid; Salty; Flat; Return Liver Channel.Merit can vomiting wind-phlegm by emesis; Improving eyesight; Removing toxic substances.
Ramulus Cinnamomi is the withe of canella Cortex Cinnamomi Cinnamomum cassia Presl.Nature and flavor acrid, sweet, warm.Enter the heart, lung, urinary bladder channel.Merit can relieving the exterior syndrome by diaphoresis, promoting the flow of QI-blood by warming the meridian, activating YANG and prormoting functioning of QI.
Fructus Setariae Germinatus (parched to brown), for the mature fruit of grass foxtail millet Setaria italica (L.) Beauv. is through drying of germinateing, fries to burnt brown according to frying method.Nature and flavor are sweet, temperature.Return spleen, stomach warp.Merit can help digestion and in, spleen benefiting and stimulating the appetite.
Compared with prior art, the present invention has following characteristics.
1, set forth one's views unique: start with from dredging collateral, to recover for the purpose of intestinal wall function of nervous system repairs, to avoid using purgatives medicine thing, although because purgatives medicine thing can solve abdominal distention for the moment, cause again new stimulation to intestinal wall, for a long time raw he become, protracted course of disease.
2, with Aspongopus, Herba Alyxiae Sinensis for monarch: inventor's clinical experience gained, bowel dysfunction is a kind of reflexive performance after art midgut wall nerve is upset, and Aspongopus regulating QI to relieve pain, Herba Alyxiae Sinensis promoting blood circulation to remove obstruction in the collateral, can reduce this zest and reflect the untoward reaction brought to intestinal.Basic pharmacology test confirms: Partial small bowel obstruction rat model Aspongopus (20g crude drug/kg/d) and Herba Alyxiae Sinensis (10g crude drug/kg/d) mixing water decocting liquid gavage, can intestinal mucosa injury be reduced, to incomplete intestinal obstruction Intestinal Mucosa, there is protective effect; And the progradation of rat intestine wriggling is observed by charcoal end method, propelling rate (84.42 ± 13.24) % of Aspongopus, Herba Alyxiae Sinensis drug combination group is apparently higher than blank group of (59.33 ± 15.62) %.
3, with the alizarin hard masses softening and resolving in sea, Herba Caryopteridis Terniflorae pungent drugs can disperse and bitter drugs can descend, digestion visible phlegm; The strong muscle of Cacumen Securinegae Suffruticosae expelling wind and activating blood circulation, kidney tonifying; Flos jasmini promoting the circulation of QI to relieve pain; Bulbus Allii Victorialis dissipating blood stasis; Nine layers of wind is enriched blood, invigorate blood circulation, dredging collateral; Azuritum assists monarch drug as ministerial drug: breath does not reach, and of a specified duration then can block by accumulation of phlegm, so select the visible phlegm in Herba Caryopteridis Terniflorae, Hai Qian, Azuritum removal intestinal venation, Flos jasmini, Cacumen Securinegae Suffruticosae, nine layers of wind increase the ability of medicines walking venations.Azuritum master is containing basic copper carbonate [2CuCO3Cu (OH) 2], and local absorption stimulates colonic fluid secretion.
4, except going back the righting of bobbin tonify deficiency subduing the wind syndrome, Cacumen Securinegae Suffruticosae, nine layers of wind are the medicine of reinforcement and elimination in combination, and Bulbus Allii Victorialis has the advantages that dissipating blood stasis does not consume gas, are particularly suitable for abdominal postoperative simulataneous insufficiency and excessive and use.
5, low dose of Ramulus Cinnamomi is corrigent, resist the anxiety that this prescription invasion by pathogenic cold medicine of a cold nature thing too much has consumption impairment of QI the moon, and the effect of its activating YANG and prormoting functioning of QI is also echoed with Aspongopus, contributes to row loose.
6, Fructus Setariae Germinatus (parched to brown) is sweet in flavor and warm in property, returns taste warp, get protect sun defend in meaning, and contained coking composition has astriction, has the meaning of receipts in loose.
7, the homogeneous medicine multiple-effect of institute's thing of getting it filled in side, contributes to reducing medicament categories and consumption, does not increase Liver and kidney burden.
8, medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, and each raw material dosage is for all to have good curative effect in following weight parts scope.
Detailed description of the invention
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: Aspongopus 20 parts, Herba Alyxiae Sinensis 10 parts, alizarin 6 parts of sea, Flos jasmini 10 parts, Herba Caryopteridis Terniflorae 6 parts, Bulbus Allii Victorialis 10 parts, go back 10 parts, bobbin, nine layers of wind 10 parts, Cacumen Securinegae Suffruticosae 10 parts, Azuritum 2 parts, Ramulus Cinnamomi 6 parts, Fructus Setariae Germinatus (parched to brown) 20 parts.
The preparation method of embodiment 1 is: by Aspongopus, Herba Alyxiae Sinensis, Hai Qian, Flos jasmini, Herba Caryopteridis Terniflorae, Bulbus Allii Victorialis, go back bobbin, nine layers of wind, Cacumen Securinegae Suffruticosae, Azuritum, Ramulus Cinnamomi, Fructus Setariae Germinatus (parched to brown) mixing and water addings decoct, filtrate is got after 30 minutes, medicinal residues add water continue decoction get filtrate after 20 minutes, twice filtrate merges, and is divided into two parts of morning and evenings to take.
Embodiment 2, crude drug weight proportion: Aspongopus 10 parts, Herba Alyxiae Sinensis 6 parts, alizarin 3 parts of sea, Flos jasmini 6 parts, Herba Caryopteridis Terniflorae 3 parts, Bulbus Allii Victorialis 6 parts, go back 6 parts, bobbin, nine layers of wind 6 parts, Cacumen Securinegae Suffruticosae 6 parts, Azuritum 1 part, Ramulus Cinnamomi 3 parts, Fructus Setariae Germinatus (parched to brown) 10 parts.
Embodiment 3, crude drug weight proportion: Aspongopus 20 parts, Herba Alyxiae Sinensis 10 parts, alizarin 6 parts of sea, Flos jasmini 10 parts, Herba Caryopteridis Terniflorae 6 parts, Bulbus Allii Victorialis 10 parts, go back 10 parts, bobbin, nine layers of wind 10 parts, Cacumen Securinegae Suffruticosae 10 parts, Azuritum 2 parts, Ramulus Cinnamomi 6 parts, Fructus Setariae Germinatus (parched to brown) 20 parts.
Embodiment 4, crude drug weight proportion: Aspongopus 30 parts, Herba Alyxiae Sinensis 12 parts, alizarin 10 parts of sea, Flos jasmini 12 parts, Herba Caryopteridis Terniflorae 10 parts, Bulbus Allii Victorialis 12 parts, go back 12 parts, bobbin, nine layers of wind 12 parts, Cacumen Securinegae Suffruticosae 12 parts, Azuritum 5 parts, Ramulus Cinnamomi 10 parts, Fructus Setariae Germinatus (parched to brown) 25 parts.
The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:
(1) bobbin will be gone back, Herba Alyxiae Sinensis, Herba Caryopteridis Terniflorae coarse powder soak separately after 4 hours and extract volatile oil 6 hours with vapor distillation, and mixing for standby use after collecting, medicinal residues are for subsequent use;
(2) Azuritum, Fructus Setariae Germinatus (parched to brown) are pulverized 150 mesh sieves, and become fine powder for subsequent use;
(3) by gained medicinal residues mixing in Aspongopus, Hai Qian, Flos jasmini, Bulbus Allii Victorialis, nine layers of wind, Cacumen Securinegae Suffruticosae, Ramulus Cinnamomi and step 1 with 5 times amount 80% ethanol extraction 2 times, each 2 hours, merge twice ethanol extract, filter, reclaiming relative density when ethanol concentrating under reduced pressure become 60 DEG C is the extractum of 1.25 ~ 1.30;
(4) gained fine powder in step 2 to be added in step 3 mixing of gained extractum, 60 DEG C of oven dry, are ground into fine powder, add Tween-80 and make granule, and dry, granulate, sprays into gained volatile oil in step 1, mix, subpackage and get final product.
The efficient combination of said medicine, coordinates mutually, effectively reach the object for the treatment of abdominal postoperative bowel dysfunction, and side effect is less.The above results is clinical data sufficient proof, and interrelated data is as follows.
1 object and method.
1.1 object.
1.1.1 case selection: case is selected from case 76 example that in June, 2011 ~ 2013 year JIUYUE is diagnosed as abdominal postoperative bowel dysfunction.Wherein abdominal surgery 37 example, obstetrics and gynecology operation 39 example.
1.1.2 abdominal postoperative bowel dysfunction diagnostic criteria:
(1) abdominal postoperative occurred in 10 days, and the persistent period was more than 30 days;
(2) 2 kinds in lower 3 kinds of situations are accompanied by, but without the need to continuously: 1. alleviate after defecation; 2. during onset of disease, defecation frequency changes (>3/d or 3< week); 3. feces character is accompanied to change during onset of disease.
1.1.3 be divided into three groups at random: matched group 25 example, decoction group 25 example, apply umbilicus group 26 example.Compare on sex, age, Operative category before three groups of patient treatments, no significant difference (P>0.05), has comparability.
1.2 method.
1.2.1 Therapeutic Method: matched group takes symptomatic treatment respectively according to constipation or diarrhoea situation, decoction group uses embodiment 1 gained decoction, 2 times/d; Embodiment 3 gained applied described in the employing of umbilicus group applies umbilicus granule vinegar and dresses umbilicus, 2 times/d, 14d altogether.
1.2.2 observation index: to main clinic symptoms (Nausea and vomiting, abdominal distention, stomachache, diarrhoea or constipation), before the treatment, 14d after treatment, 30d marks according to Self-reporting inventory after drug withdrawal, nothing: be 0 point without this symptom; Slight: conscious have this symptom, but do not take place frequently, not serious is 1 point; Moderate: conscious have this symptom is 2 points between light, heavier; Heavier: to have significantly this symptom, between Jie Yuzhong, severe, be 3 points; Severe: the frequency of this symptom conscious and intensity are 4 points all very strongly.
1.2.3 criterion of therapeutical effect: symptom total score × 100% before therapeutic index (%)=(before treatment the rear symptom total score of symptom total score-treatment)/treatment.Curative effect is judged by therapeutic index, effective: therapeutic index >76%; Effective: therapeutic index is 51% ~ 75%; Take a turn for the better: therapeutic index is 26% ~ 50%; Invalid: therapeutic index <25%.
1.2.4 relapse criteria: symptom total score × 100% after recurrence index (%)=(after drug withdrawal the rear symptom total score of 30d symptom total score-treatment)/treatment.Recurrence index >50% is then judged as recurrence.
1.2.5 statistical analysis: SPSS 13.0 carries out statistical analysis.Measurement data t checks, enumeration data χ
2inspection.
2 results.
2.1 3 groups of Clinical efficacy comparisons: see the following form.Result shows: the total effective rate of decoction group and deposited umbilicus group is apparently higher than matched group (P<0.05).
| Group | Number of cases | Effective | Effectively | Take a turn for the better | Invalid | Total effective rate |
| Matched group | 25 | 6（8.00%） | 9（36.00%） | 3（12.00%） | 7（28.00%） | 72.00% |
| Decoction group | 25 | 13（52.00%） | 7（28.00%） | 4（16.00%） | 1（4.00%） | 96.00% |
| Apply umbilicus group | 26 | 11（42.31%） | 9（34.62%） | 4（15.38%） | 2（7.69%） | 92.31% |
Relapse rate in 2.2 3 groups of patient half days: have 38.89%(7/18 during the effective patient 30d for the treatment of of control group) patient there is recurrence, decoction group is 4.17%(1/24), applying umbilicus group is 8.33%(1/24), the relapse rate of decoction group and deposited umbilicus group is all starkly lower than matched group (P<0.01).
2.3 3 groups of adverse reactions of patients incidence rates compare: three groups all do not occur obvious adverse reaction record.
3. conclusion.
This result of study shows, after taking decoction of the present invention or deposited umbilicus, abdominal postoperative bowel dysfunction patient cure rate, total effective rate are apparently higher than matched group, and relapse rate is starkly lower than matched group, there is not obvious adverse reaction record, illustrate that pharmaceutical composition of the present invention has the lighter advantage of good effect, untoward reaction in treatment abdominal postoperative bowel dysfunction.
Claims (2)
1. treat the pharmaceutical composition of abdominal postoperative bowel dysfunction for one kind, it is characterized in that being prepared from by the crude drug of following weight proportion: Aspongopus 10 ~ 30 parts, Herba Alyxiae Sinensis 6 ~ 12 parts, alizarin 3 ~ 10 parts of sea, Flos jasmini 6 ~ 12 parts, Herba Caryopteridis Terniflorae 3 ~ 10 parts, Bulbus Allii Victorialis 6 ~ 12 parts, go back 6 ~ 12 parts, bobbin, nine layers of wind 6 ~ 12 parts, Cacumen Securinegae Suffruticosae 6 ~ 12 parts, Azuritum 1 ~ 5 part, Ramulus Cinnamomi 3 ~ 10 parts, Fructus Setariae Germinatus (parched to brown) 10 ~ 25 parts, described pharmaceutical composition is used for the treatment of abdominal postoperative bowel dysfunction.
2. a kind of pharmaceutical composition for the treatment of abdominal postoperative bowel dysfunction according to claim 1, is characterized in that being prepared from by the crude drug of following weight proportion: Aspongopus 20 parts, Herba Alyxiae Sinensis 10 parts, alizarin 6 parts of sea, Flos jasmini 10 parts, Herba Caryopteridis Terniflorae 6 parts, Bulbus Allii Victorialis 10 parts, go back 10 parts, bobbin, 99 layers of wind 10 parts, Cacumen Securinegae Suffruticosae 10 parts, Azuritum 2 parts, Ramulus Cinnamomi 6 parts, Fructus Setariae Germinatus (parched to brown) 20 parts.
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| CN113956369B (en) * | 2021-10-21 | 2022-09-27 | 河南省医药科学研究院 | Preparation method and application of Caryopteris clandonensis polysaccharide |
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| CN101804173A (en) * | 2010-05-28 | 2010-08-18 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composition for treating dyspepsia and preparation method thereof |
| CN101804172A (en) * | 2010-05-28 | 2010-08-18 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composition for treating anorexia and preparation method thereof |
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| CN101804173A (en) * | 2010-05-28 | 2010-08-18 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composition for treating dyspepsia and preparation method thereof |
| CN101804172A (en) * | 2010-05-28 | 2010-08-18 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composition for treating anorexia and preparation method thereof |
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