CN103494957A - Preparation method of Jinma Gantai preparation for treating hepatitis - Google Patents
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- 238000002360 preparation method Methods 0.000 title claims abstract description 28
- 208000006454 hepatitis Diseases 0.000 title claims abstract description 16
- 231100000283 hepatitis Toxicity 0.000 title claims abstract description 12
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 182
- 239000007788 liquid Substances 0.000 claims description 54
- 238000000605 extraction Methods 0.000 claims description 47
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 34
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 26
- 239000000706 filtrate Substances 0.000 claims description 24
- 239000000203 mixture Substances 0.000 claims description 16
- 239000008187 granular material Substances 0.000 claims description 15
- 239000002253 acid Substances 0.000 claims description 13
- 229910021529 ammonia Inorganic materials 0.000 claims description 13
- 230000006837 decompression Effects 0.000 claims description 13
- 238000011084 recovery Methods 0.000 claims description 13
- 230000001105 regulatory effect Effects 0.000 claims description 13
- 150000003839 salts Chemical class 0.000 claims description 13
- 239000002904 solvent Substances 0.000 claims description 13
- 238000001035 drying Methods 0.000 claims description 11
- 210000004185 liver Anatomy 0.000 claims description 10
- 239000009636 Huang Qi Substances 0.000 claims description 7
- 229920002472 Starch Polymers 0.000 claims description 6
- -1 dry Substances 0.000 claims description 6
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 6
- 239000008107 starch Substances 0.000 claims description 6
- 235000019698 starch Nutrition 0.000 claims description 6
- 239000002775 capsule Substances 0.000 claims description 5
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 4
- 229930006000 Sucrose Natural products 0.000 claims description 4
- 239000002671 adjuvant Substances 0.000 claims description 4
- 238000009472 formulation Methods 0.000 claims description 4
- 239000005720 sucrose Substances 0.000 claims description 4
- 235000019359 magnesium stearate Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 2
- 241001247852 Berchemia Species 0.000 abstract 1
- 241000506964 Dichondra repens Species 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 24
- 238000000034 method Methods 0.000 description 11
- 239000000243 solution Substances 0.000 description 9
- 239000012567 medical material Substances 0.000 description 8
- 238000004064 recycling Methods 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- 238000000746 purification Methods 0.000 description 5
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000012216 screening Methods 0.000 description 4
- 206010023126 Jaundice Diseases 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 3
- 238000003304 gavage Methods 0.000 description 3
- 238000001802 infusion Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 206010008909 Chronic Hepatitis Diseases 0.000 description 2
- YKRGDOXKVOZESV-WRJNSLSBSA-N Paeoniflorin Chemical compound C([C@]12[C@H]3O[C@]4(O)C[C@](O3)([C@]1(C[C@@H]42)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)C)OC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-WRJNSLSBSA-N 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 231100000354 acute hepatitis Toxicity 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000005457 optimization Methods 0.000 description 2
- 208000037920 primary disease Diseases 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- JCZPMGDSEAFWDY-MGCNEYSASA-N (2r,3s,4s,5r)-2,3,4,5,6-pentahydroxyhexanamide Chemical compound NC(=O)[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO JCZPMGDSEAFWDY-MGCNEYSASA-N 0.000 description 1
- 241000324343 Causa Species 0.000 description 1
- 206010067125 Liver injury Diseases 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 231100000753 hepatic injury Toxicity 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a preparation method of a Jinma Gantai preparation for treating hepatitis, belonging to the technical field of traditional Chinese medicines. The product is prepared from dichondra repens, berchemia lineate and the like and is prepared into pharmaceutically allowable dosage forms. The preparation has good stability and high bioavailability, is convenient to take, has beautiful and clean appearance and is easy to accept by the patients. The provided preparation method can be used for effectively preparing the needed preparation and ensuring that the production process of the prepared preparation is scientific and reasonable.
Description
Technical field
The present invention is a kind of preparation method for the treatment of the safe preparation of Golden Horse liver of hepatitis, belongs to the technical field of Chinese medicine.
Technical background
Hepatitis, by state of an illness weight, can be divided into plain edition hepatitis and hepatitis gravis; With its course of disease length, can be divided into acute hepatitis and chronic hepatitis.Primary disease belongs to the category of the diseases such as the traditional Chinese medical science " jaundice ", " costalgia ", " fulminant jaundice ", " acute jaundice ".Learn angle from tcm causa morbi and analyze, damp and hot is the Basic disease cause of primary disease, and runs through the course of disease all the time.The safe granule of Golden Horse liver is made by Herba Dichodrae, Radix berchemiae lineatae, Herba Verbenae, Radix Stephaniae Tetrandrae, Herba Patriniae, Herba Epimedii, the Radix Astragali, Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae; The effect heat-clearing and toxic substances removing, invigorating spleen to remove dampness, blood circulation promoting and blood stasis dispelling; For dampness-heat in the liver and gallbladder, the acute hepatitis, chronic hepatitis of caused by energy stagnation and blood stasis.Existing product adopts the technique of WS-10313 (ZD-0313)-2002-2012Z record, and the method simple coarse, cause active constituent content on the low side, affects the treatment.
So in view of such circumstances, providing a kind of rational preparation method is to be badly in need of the thing solved.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of preparation method.
Technical scheme of the present invention is to form like this:
A kind of Chinese medicine preparation is by Herba Dichodrae 288.2g, Radix berchemiae lineatae 153.3g, Herba Verbenae 115g, Radix Stephaniae Tetrandrae 191.6g, Herba Patriniae 115g, Herba Epimedii 153.3g, Radix Astragali 153.3g, Radix Paeoniae Rubra 153.3g, Radix Salviae Miltiorrhizae 230 and adjuvant are prepared from as follows: the thing of getting it filled, add 6 times of decoctings to boil 2 times, each 1.5 hours, collecting decoction, filter, the clear paste of 1.14-1.16 when filtrate is concentrated into relative density and is 70-75 ℃, be cooled to room temperature, add the equivalent n-butanol extraction 2 times, merge n-butyl alcohol liquid, water liquid salt adding acid for adjusting pH is 3-4, add the equivalent n-butanol extraction 2 times, merge butanol solution, it is 9-10 that water liquid is regulated pH with ammonia, add the equivalent n-butanol extraction 2 times, merge all n-butyl alcohol liquid, when decompression and solvent recovery is 50-60 ℃ to relative density, the thick paste of 1.34-1.40 adds adjuvant, make oral formulations.Described oral formulations refers to capsule, granule, tablet.
Specifically: the thing of getting it filled, add 6 times of decoctings to boil 2 times, each 1.5 hours, collecting decoction, filter, the clear paste of 1.14-1.16 when filtrate is concentrated into relative density and is 70-75 ℃, be cooled to room temperature, add the equivalent n-butanol extraction 2 times, merge n-butyl alcohol liquid, water liquid salt adding acid for adjusting pH is 3-4, add the equivalent n-butanol extraction 2 times, merge butanol solution, it is 9-10 that water liquid is regulated pH with ammonia, add the equivalent n-butanol extraction 2 times, merge all n-butyl alcohol liquid, the thick paste of 1.34-1.40 when decompression and solvent recovery is 50-60 ℃ to relative density, add 4 times of amount sucrose, mix homogeneously, granulate, dry, granulate obtains granule.
The thing of getting it filled, add 6 times of decoctings to boil 2 times, each 1.5 hours, collecting decoction, filter, the clear paste of 1.14-1.16 when filtrate is concentrated into relative density and is 70-75 ℃, be cooled to room temperature, add the equivalent n-butanol extraction 2 times, merge n-butyl alcohol liquid, water liquid salt adding acid for adjusting pH is 3-4, add the equivalent n-butanol extraction 2 times, merge butanol solution, it is 9-10 that water liquid is regulated pH with ammonia, add the equivalent n-butanol extraction 2 times, merge all n-butyl alcohol liquid, the thick paste of 1.34-1.40 when decompression and solvent recovery is 50-60 ℃ to relative density, drying under reduced pressure, pulverize, the magnesium stearate that adds appropriate amount of starch and 0.2%, mix homogeneously, fill, obtain capsule.
The thing of getting it filled, add 6 times of decoctings to boil 2 times, each 1.5 hours, collecting decoction, filter, the clear paste of 1.14-1.16 when filtrate is concentrated into relative density and is 70-75 ℃, be cooled to room temperature, add the equivalent n-butanol extraction 2 times, merge n-butyl alcohol liquid, water liquid salt adding acid for adjusting pH is 3-4, add the equivalent n-butanol extraction 2 times, merge butanol solution, it is 9-10 that water liquid is regulated pH with ammonia, add the equivalent n-butanol extraction 2 times, merge all n-butyl alcohol liquid, the thick paste of 1.34-1.40 when decompression and solvent recovery is 50-60 ℃ to relative density, drying under reduced pressure, pulverize, add in right amount and can press starch, mix homogeneously, tabletting obtains tablet.
Experimental example:
1. optimization for extracting condition
The extraction ratio of peoniflorin of take is performance assessment criteria, adopts the orthogonal experiment of four factor three levels, optimizes the impact on the extraction ratio of peoniflorin of screening amount of water (A), extraction time (B) and extraction time (C), and the factor level table is as follows:
Determine that through optimizing screening best extraction conditions is: A
1b
2c
2, with 6 times of water gagings, decoct 2 times each 1.5 hours; Carry out the parallel verified test as condition, result of the test is as follows:
From top test, can find out, stable through the extraction conditions of screening.
2. purification condition optimization
Extract preparation: take each medical material, add 6 times of decoctings to boil 2 times, each 1.5 hours, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.14～1.16 (70～75 ℃), is divided into 2 parts, carry out purification with distinct methods respectively, investigate the impact of purification condition on the effective ingredient rate of transform.
Method one: clear paste is cooled to room temperature, adds 2 times of amount ethanol, stir, place 48 hours, filter, filtrate recycling ethanol, being concentrated into relative density is 1.34～1.40 (50～60 ℃), drying under reduced pressure is measured content.
Method two: clear paste is cooled to room temperature, add the equivalent n-butanol extraction 2 times, merge n-butyl alcohol liquid, water liquid salt adding acid for adjusting pH is 3～4, add the equivalent n-butanol extraction 2 times, merge butanol solution, it is 9～10 that water liquid is regulated pH with ammonia, adds the equivalent n-butanol extraction 2 times, merge all n-butyl alcohol liquid, the thick paste that decompression and solvent recovery to relative density is 1.34～1.40 (50～60 ℃), drying under reduced pressure, measure content.
From top active constituent content, can find out, the purification effect of purification process two ratio method one is good.
3. the impact of different process route on the product drug effect
Because the chemical composition of different process route enrichments is distinguished to some extent, still the technique after screening and other preparation technology commonly used are carried out to the pharmacology curative effect relatively, sample preparation and therapeutic evaluation result are as follows:
Sample 1: take each medical material, add 6 times of decoctings to boil 2 times, each 1.5 hours, collecting decoction, filter, and filtrate is concentrated into the clear paste that relative density is 1.14～1.16 (90～95 ℃), clear paste is cooled to room temperature, add 2 times of amount ethanol, stir, place 48 hours, filter, filtrate recycling ethanol, being concentrated into relative density is 1.34～1.40 (50～60 ℃), drying under reduced pressure.
Sample 2: take each medical material, add 6 times of decoctings to boil 2 times, each 1.5 hours, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.14～1.16 (70～75 ℃), be cooled to room temperature, add the equivalent n-butanol extraction 2 times, merge n-butyl alcohol liquid, water liquid salt adding acid for adjusting pH is 3～4, add the equivalent n-butanol extraction 2 times, merge butanol solution, it is 9～10 that water liquid is regulated pH with ammonia, add the equivalent n-butanol extraction 2 times, merge all n-butyl alcohol liquid, the thick paste that decompression and solvent recovery to relative density is 1.34～1.40 (50～60 ℃), drying under reduced pressure.
Sample 3: get Herba Epimedii, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra and Radix Stephaniae Tetrandrae and mix, add 8 times of amount 70% alcohol reflux 2 times, each 1 hour, extracting liquid filtering, filtrate recycling ethanol is concentrated into the clear paste that relative density is 1.14～1.16 (70～75 ℃), is cooled to room temperature, add 2 times of water gagings, stir, filter, filtrate is concentrated into the thick paste that relative density is 1.34～1.40 (50～60 ℃); The residue medical material adds 6 times of decoctings to boil 2 times, and each 1.5 hours, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.14～1.16 (70～75 ℃), is cooled to room temperature, adds 2 times of amount ethanol, stir, place 48 hours, filter, filtrate recycling ethanol is concentrated into the thick paste that relative density is 1.34～1.40 (50～60 ℃), thick paste and above-mentioned alcohol extraction thick paste merge, drying under reduced pressure.
Protective effect research to D mono-aminogalactose acute liver: by tested mice, random packet, 10 every group.D mono-aminogalactose amine model group: press Mouse Weight 20mL/kg distilled water gavage.Sample sets: press 2g/kg gavage respectively.Matched group: 20mL/kg distilled water gavage.The continuous gastric infusion 3d of each treated animal, every day 1 time, 1h after the 4th day gastric infusion, except matched group, all the other 4 treated animals are through the D of lumbar injection 100g/L mono-aminogalactose amine 500g/kg.Continue gastric infusion, put to death animal after 24h and get blood, centrifugal, get serum, automatic clinical chemistry analyzer detects.
This experiment is by lumbar injection D-GlaN, observed sample prepared by the different process impact on the D-G1aN liver injury model.Result shows, the application's technique (2 groups, sample) can effective rich active ingredient, improved the curative effect of product.
Concrete embodiment
Embodiment 1: Herba Dichodrae 288.2g, Radix berchemiae lineatae 153.3g, Herba Verbenae 115g, Radix Stephaniae Tetrandrae 191.6g, Herba Patriniae 115g, Herba Epimedii 153.3g, Radix Astragali 153.3g, Radix Paeoniae Rubra 153.3g, Radix Salviae Miltiorrhizae 230g
Above nine flavor medical materials, add 6 times of decoctings to boil 2 times, each 1.5 hours, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.14～1.16 (70～75 ℃), be cooled to room temperature, add the equivalent n-butanol extraction 2 times, merge n-butyl alcohol liquid, water liquid salt adding acid for adjusting pH is 3～4, add the equivalent n-butanol extraction 2 times, merge butanol solution, it is 9～10 that water liquid is regulated pH with ammonia, add the equivalent n-butanol extraction 2 times, merge all n-butyl alcohol liquid, the thick paste that decompression and solvent recovery to relative density is 1.34～1.40 (50～60 ℃), add 4 times of amount sucrose, mix homogeneously, granulate, dry, granulate obtains granule, boiled water is taken after mixing it with water, a 10g, 3 times on the one.
Embodiment 2: Herba Dichodrae 288.2g, Radix berchemiae lineatae 153.3g, Herba Verbenae 115g, Radix Stephaniae Tetrandrae 191.6g, Herba Patriniae 115g, Herba Epimedii 153.3g, Radix Astragali 153.3g, Radix Paeoniae Rubra 153.3g, Radix Salviae Miltiorrhizae 230g
Above nine flavor medical materials, add 6 times of decoctings to boil 2 times, each 1.5 hours, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.14～1.16 (70～75 ℃), be cooled to room temperature, add the equivalent n-butanol extraction 2 times, merge n-butyl alcohol liquid, water liquid salt adding acid for adjusting pH is 3～4, add the equivalent n-butanol extraction 2 times, merge butanol solution, it is 9～10 that water liquid is regulated pH with ammonia, add the equivalent n-butanol extraction 2 times, merge all n-butyl alcohol liquid, the thick paste that decompression and solvent recovery to relative density is 1.34～1.40 (50～60 ℃), drying under reduced pressure, pulverize, the magnesium stearate that adds appropriate amount of starch and 0.2%, mix homogeneously, fill, obtain capsule.
Embodiment 3: Herba Dichodrae 288.2g, Radix berchemiae lineatae 153.3g, Herba Verbenae 115g, Radix Stephaniae Tetrandrae 191.6g, Herba Patriniae 115g, Herba Epimedii 153.3g, Radix Astragali 153.3g, Radix Paeoniae Rubra 153.3g, Radix Salviae Miltiorrhizae 230g
Above nine flavor medical materials, add 6 times of decoctings to boil 2 times, each 1.5 hours, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.14～1.16 (70～75 ℃), be cooled to room temperature, add the equivalent n-butanol extraction 2 times, merge n-butyl alcohol liquid, water liquid salt adding acid for adjusting pH is 3～4, add the equivalent n-butanol extraction 2 times, merge butanol solution, it is 9～10 that water liquid is regulated pH with ammonia, add the equivalent n-butanol extraction 2 times, merge all n-butyl alcohol liquid, the thick paste that decompression and solvent recovery to relative density is 1.34～1.40 (50～60 ℃), drying under reduced pressure, pulverize, add in right amount and can press starch, mix homogeneously, tabletting obtains tablet.
Embodiment 4 Herba Dichodrae 288.2g, Radix berchemiae lineatae 153.3g, Herba Verbenae 115g, Radix Stephaniae Tetrandrae 191.6g, Herba Patriniae 115g, Herba Epimedii 153.3g, Radix Astragali 153.3g, Radix Paeoniae Rubra 153.3g, Radix Salviae Miltiorrhizae 230g
Getting Herba Epimedii, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra and Radix Stephaniae Tetrandrae mixes, add 8 times of amount 70% alcohol reflux 2 times, each 1 hour, extracting liquid filtering, filtrate recycling ethanol is concentrated into the clear paste that relative density is 1.14～1.16 (70～75 ℃), is cooled to room temperature, add 2 times of water gagings, stir, filter, filtrate is concentrated into the thick paste that relative density is 1.34～1.40 (50～60 ℃); The residue medical material adds 6 times of decoctings to boil 2 times, and each 1.5 hours, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.14～1.16 (70～75 ℃), is cooled to room temperature, add 2 times of amount ethanol, stir, place 48 hours, filter, filtrate recycling ethanol is concentrated into the thick paste that relative density is 1.34～1.40 (50～60 ℃), and thick paste and above-mentioned alcohol extraction thick paste merge, mix, add 4 times of amount sucrose, granulate, dry, granulate, obtain granule.
Claims (5)
1. the preparation method of the safe preparation of the Golden Horse liver for the treatment of hepatitis, it is characterized in that: it is by Herba Dichodrae 288.2g, Radix berchemiae lineatae 153.3g, Herba Verbenae 115g, Radix Stephaniae Tetrandrae 191.6g, Herba Patriniae 115g, Herba Epimedii 153.3g, Radix Astragali 153.3g, Radix Paeoniae Rubra 153.3g, Radix Salviae Miltiorrhizae 230 and adjuvant are prepared from as follows: the thing of getting it filled, add 6 times of decoctings to boil 2 times, each 1.5 hours, collecting decoction, filter, the clear paste of 1.14-1.16 when filtrate is concentrated into relative density and is 70-75 ℃, be cooled to room temperature, add the equivalent n-butanol extraction 2 times, merge n-butyl alcohol liquid, water liquid salt adding acid for adjusting pH is 3-4, add the equivalent n-butanol extraction 2 times, merge butanol solution, it is 9-10 that water liquid is regulated pH with ammonia, add the equivalent n-butanol extraction 2 times, merge all n-butyl alcohol liquid, when decompression and solvent recovery is 50-60 ℃ to relative density, the thick paste of 1.34-1.40 adds adjuvant, make oral formulations.
2. according to the preparation method of the safe preparation of the Golden Horse liver for the treatment of hepatitis claimed in claim 1, it is characterized in that: described oral formulations refers to capsule, granule, tablet.
3. according to the preparation method of the safe preparation of the Golden Horse liver for the treatment of hepatitis claimed in claim 2, it is characterized in that: the thing of getting it filled, add 6 times of decoctings to boil 2 times, each 1.5 hours, collecting decoction, filter, the clear paste of 1.14-1.16 when filtrate is concentrated into relative density and is 70-75 ℃, be cooled to room temperature, add the equivalent n-butanol extraction 2 times, merge n-butyl alcohol liquid, water liquid salt adding acid for adjusting pH is 3-4, add the equivalent n-butanol extraction 2 times, merge butanol solution, it is 9-10 that water liquid is regulated pH with ammonia, add the equivalent n-butanol extraction 2 times, merge all n-butyl alcohol liquid, the thick paste of 1.34-1.40 when decompression and solvent recovery is 50-60 ℃ to relative density, add 4 times of amount sucrose, mix homogeneously, granulate, dry, granulate obtains granule.
4. according to the preparation method of the safe preparation of the Golden Horse liver for the treatment of hepatitis claimed in claim 2, it is characterized in that: the thing of getting it filled, add 6 times of decoctings to boil 2 times, each 1.5 hours, collecting decoction, filter, the clear paste of 1.14-1.16 when filtrate is concentrated into relative density and is 70-75 ℃, be cooled to room temperature, add the equivalent n-butanol extraction 2 times, merge n-butyl alcohol liquid, water liquid salt adding acid for adjusting pH is 3-4, add the equivalent n-butanol extraction 2 times, merge butanol solution, it is 9-10 that water liquid is regulated pH with ammonia, add the equivalent n-butanol extraction 2 times, merge all n-butyl alcohol liquid, the thick paste of 1.34-1.40 when decompression and solvent recovery is 50-60 ℃ to relative density, drying under reduced pressure, pulverize, the magnesium stearate that adds appropriate amount of starch and 0.2%, mix homogeneously, fill, obtain capsule.
5. according to the preparation method of the safe preparation of the Golden Horse liver for the treatment of hepatitis claimed in claim 2, it is characterized in that: the thing of getting it filled, add 6 times of decoctings to boil 2 times, each 1.5 hours, collecting decoction, filter, the clear paste of 1.14-1.16 when filtrate is concentrated into relative density and is 70-75 ℃, be cooled to room temperature, add the equivalent n-butanol extraction 2 times, merge n-butyl alcohol liquid, water liquid salt adding acid for adjusting pH is 3-4, add the equivalent n-butanol extraction 2 times, merge butanol solution, it is 9-10 that water liquid is regulated pH with ammonia, add the equivalent n-butanol extraction 2 times, merge all n-butyl alcohol liquid, the thick paste of 1.34-1.40 when decompression and solvent recovery is 50-60 ℃ to relative density, drying under reduced pressure, pulverize, add in right amount and can press starch, mix homogeneously, tabletting obtains tablet.
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| CN102813752A (en) * | 2012-09-05 | 2012-12-12 | 贵州百花医药股份有限公司 | Preparation method of creeping dichondra-berchemia lineata-verbena Gantai preparation |
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| CN108718931A (en) * | 2018-04-25 | 2018-11-02 | 覃福裕 | The artificial cultivation method of dewdrop grass |
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