CN103494851A - Preparation method of Wei Shuxin preparation - Google Patents
Preparation method of Wei Shuxin preparation Download PDFInfo
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- CN103494851A CN103494851A CN201310455857.8A CN201310455857A CN103494851A CN 103494851 A CN103494851 A CN 103494851A CN 201310455857 A CN201310455857 A CN 201310455857A CN 103494851 A CN103494851 A CN 103494851A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 35
- 241001453169 Asplenium Species 0.000 claims abstract description 12
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 62
- 238000000605 extraction Methods 0.000 claims description 26
- 239000000706 filtrate Substances 0.000 claims description 23
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 20
- 239000000203 mixture Substances 0.000 claims description 20
- 230000006837 decompression Effects 0.000 claims description 19
- 239000007788 liquid Substances 0.000 claims description 16
- 239000006071 cream Substances 0.000 claims description 15
- 239000008187 granular material Substances 0.000 claims description 13
- 238000001035 drying Methods 0.000 claims description 12
- 238000011084 recovery Methods 0.000 claims description 12
- 239000002904 solvent Substances 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 210000002784 stomach Anatomy 0.000 claims description 11
- 229920002472 Starch Polymers 0.000 claims description 6
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 6
- 229930006000 Sucrose Natural products 0.000 claims description 6
- 239000002775 capsule Substances 0.000 claims description 6
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 6
- 239000008107 starch Substances 0.000 claims description 6
- 235000019698 starch Nutrition 0.000 claims description 6
- 239000005720 sucrose Substances 0.000 claims description 6
- 239000002671 adjuvant Substances 0.000 claims description 4
- -1 drying Substances 0.000 claims description 4
- 238000009472 formulation Methods 0.000 claims description 4
- 238000004064 recycling Methods 0.000 claims description 4
- 238000010992 reflux Methods 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 3
- 235000019359 magnesium stearate Nutrition 0.000 claims description 3
- 238000012856 packing Methods 0.000 claims description 3
- 229940075582 sorbic acid Drugs 0.000 claims description 3
- 235000010199 sorbic acid Nutrition 0.000 claims description 3
- 239000004334 sorbic acid Substances 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 claims description 3
- 238000005352 clarification Methods 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 241000331432 Cynanchum wilfordii Species 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 1
- 229930003944 flavone Natural products 0.000 description 15
- 235000011949 flavones Nutrition 0.000 description 15
- 150000002213 flavones Chemical class 0.000 description 14
- 238000000034 method Methods 0.000 description 11
- 238000000746 purification Methods 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 239000012567 medical material Substances 0.000 description 5
- 239000000796 flavoring agent Substances 0.000 description 4
- 235000019634 flavors Nutrition 0.000 description 4
- 208000012895 Gastric disease Diseases 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000005469 granulation Methods 0.000 description 3
- 230000003179 granulation Effects 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 229930182470 glycoside Natural products 0.000 description 2
- 150000002338 glycosides Chemical class 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000005457 optimization Methods 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 208000018556 stomach disease Diseases 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 206010067171 Regurgitation Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 238000003483 aging Methods 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 235000020965 cold beverage Nutrition 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000002183 duodenal effect Effects 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical group CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 239000013558 reference substance Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a preparation method of a Wei Shuxin preparation, belonging to the technical field of traditional Chinese medicines. The product is prepared from spleenwort and cynanchum wilfordii and is prepared into pharmaceutically allowable dosage forms. The preparation has good stability and high bioavailability, is convenient to take, has beautiful and clean appearance and is easy to accept by the patients. The provided preparation method can be used for effectively preparing the needed preparation and ensuring that the production process of the prepared preparation is scientific and reasonable.
Description
Technical field
The present invention is a kind of preparation method of stomach Shu Xin preparation, belongs to the technical field of Chinese medicine.
Technical background
Because the change of life style, the sickness rate of gastropathy increases year by year, has at present nearly seventy percent in the general population and suffers from gastropathy.And drink cold drink due to learning pressure and happiness, patients with gastric disease has been the trend of becoming younger especially.Stomach Shu Xin granule is made by Asplenium trchomanes L., Radix cynanchi wilfordii; Effect replenishing YIN and removing heat, and stomach and alleviating pain; Gastralgia due to hindering for gastric heat is cloudy, the belch acid regurgitation; Stomach and duodenal bulbar ulcer.Existing product adopts the technique of WS-11501 (ZD-1501)-2002 record, and the method simple coarse, cause active constituent content on the low side, affects the treatment.Researcher is also arranged in order to improve the content of effective ingredient, adopt methanol solution as extractant, but the methanol used is larger to the human injury.
So in view of such circumstances, providing a kind of reasonable safe preparation method is to be badly in need of the thing solved.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of preparation method.
Technical scheme of the present invention is to form like this:
A kind of Chinese medicine preparation is prepared from as follows by Asplenium trchomanes L. 333.3g, Radix cynanchi wilfordii 333.3g and adjuvant: the thing of getting it filled, add 8 times of decoctings to boil 3 times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction, filter, and filtrate is 1.20 clear paste while being concentrated into 80 ℃ of relative densities, treat that cream is chilled to 40 ℃, clarification, add adjuvant, makes oral formulations.Described oral formulations refers to capsule, granule, tablet.
The preparation method of described granule: the thing of getting it filled, add 8 times of decoctings to boil 3 times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction, filter, filtrate is 1.20 clear paste while being concentrated into 80 ℃ of relative densities, treats that cream is chilled to 40 ℃, add the equivalent n-butanol extraction 3 times, merge n-butyl alcohol liquid, decompression and solvent recovery is 1.25 clear paste during to 80 ℃ of relative densities, add 950g sucrose, mix homogeneously, granulate, drying, granulate obtains granule.
The preparation method of described capsule: the thing of getting it filled, add 8 times of decoctings to boil 3 times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction, filter, filtrate is 1.20 clear paste while being concentrated into 80 ℃ of relative densities, treats that cream is chilled to 40 ℃, add the equivalent n-butanol extraction 3 times, merge n-butyl alcohol liquid, decompression and solvent recovery is 1.25 clear paste during to 80 ℃ of relative densities, drying under reduced pressure, pulverize, and adds the magnesium stearate of appropriate amount of starch and 0.2%, mix homogeneously, fill, obtain capsule.
The preparation method of described tablet is characterized in that: the thing of getting it filled adds 8 times of decoctings to boil 3 times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction, filter, and filtrate is 1.20 clear paste while being concentrated into 80 ℃ of relative densities, treat that cream is chilled to 40 ℃, add the equivalent n-butanol extraction 3 times, merge n-butyl alcohol liquid, decompression and solvent recovery is 1.25 clear paste during to 80 ℃ of relative densities, and drying under reduced pressure, pulverize, add in right amount and can press starch, mix homogeneously, tabletting obtains tablet.
The preparation method of described oral liquid is characterized in that: add 8 times of amount 70% alcohol reflux 3 times, each 1 hour, filter, decompression filtrate recycling ethanol, to the clear paste that 60 ℃ of relative densities are 1.20, adds 2 times of water gagings, fully stir 30 minutes, filter, filtrate decompression is concentrated into 800ml, add 100g sucrose and 2g sorbic acid, add water to 1000ml, mix homogeneously, packing, sterilizing, obtain oral liquid.
Experimental example:
Take the Rhizoma Kaempferiae glycosides as reference substance, adopt aluminum chloride determination of color total flavones, and to take the extraction ratio of total flavones be performance assessment criteria, optimize the screening total flavones and extract purification condition, and carried out effect experiment.
1. optimization for extracting condition
(1) amount of water is investigated
Take respectively Asplenium trchomanes L. 111.1g and Radix cynanchi wilfordii 111.1g, totally 3 parts, add respectively the various dose decocting to boil 3 times, each 2 hours, the extraction ratio of total flavones of take was the impact of index examination amount of water on the total flavones stripping.
Can find out from the above results, adopt 8 times of amounts and 10 times of water gagings all can obtain good result, but, in conjunction with manufacturing cost and energy consumption, we preferably add 8 times of water gagings.
(2) extraction time is investigated
Take respectively Asplenium trchomanes L. 111.1g and Radix cynanchi wilfordii 111.1g, totally 3 parts, add respectively 8 times of water gagings to decoct, each 2 hours, the extraction ratio of total flavones of take was the impact of index examination extraction time on the total flavones stripping.
From the above results, can find out, the extraction ratio of total flavones raises along with the increase of extraction time, but extract 4 times with extract the effect of 3 times without marked difference, for saving, we adopt 3 extractions man-hour.
(3) extraction time is investigated
Take respectively Asplenium trchomanes L. 111.1g and Radix cynanchi wilfordii 111.1g, totally 3 parts, add respectively 8 times of decoctings to boil 3 times, the extraction ratio of total flavones of take is the impact on the total flavones stripping of index examination extraction time.
From the above results, can find out, different ageings has a certain impact to the extraction ratio of total flavones, in conjunction with the extraction ratio of man-hour and total flavones, we determine the combination that adopts No. 2 experiments, extract 2 hours for the first time 3 times, 1.5 hours for the second time, 1 hour for the third time.
2. purification condition optimization
Extract preparation: take each medical material, add 8 times of decoctings to boil 3 times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.20 (80 ℃), is divided into 2 parts, carry out purification with distinct methods respectively, investigate the impact of purification condition on the total flavones rate of transform.
Method one: clear paste is cooled to 40 ℃, adds 2 times of amount ethanol, mix, place 24 hours, get supernatant, filter, reclaim ethanol, being concentrated into relative density is 1.25 (80 ℃), and drying under reduced pressure is measured content.
Method two: treat that cream is chilled to 40 ℃, add the equivalent n-butanol extraction 3 times, merge n-butyl alcohol liquid, the clear paste that decompression and solvent recovery to relative density is 1.25 (80 ℃), drying under reduced pressure, measure content.
From the top total flavones rate of transform, can find out, the purification effect of purification process two ratio method one is good, and it is good than first method that effective ingredient retains, still selected purification process be: add the equivalent n-butanol extraction 3 times.
3. preparation technology's checking
Take each 222.2g of Asplenium trchomanes L. and Radix cynanchi wilfordii, mix totally 3 parts.Add 8 times of decoctings to boil 3 times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction, filtered, filtrate is concentrated into the clear paste that relative density is 1.20 (80 ℃), treat that cream is chilled to 40 ℃, add the equivalent n-butanol extraction 3 times, merge n-butyl alcohol liquid, the clear paste that decompression and solvent recovery to relative density is 1.25 (80 ℃), drying under reduced pressure, pulverize, and measures general flavone content and Rhizoma Kaempferiae glycosides content.
4. the impact of different process route on the product drug effect
Because the chemical composition of different process route enrichments is distinguished to some extent, still the technique after screening and other preparation technology commonly used are carried out to the pharmacology curative effect relatively, sample preparation and therapeutic evaluation result are as follows:
Sample 1: the thing of getting it filled, add 8 times of decoctings to boil 3 times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction, filter, filtrate is 1.20 clear paste while being concentrated into 80 ℃ of relative densities, treats that cream is chilled to 40 ℃, add 2 times of ethanol, mix, standing 24 hours, get supernatant, filter, reclaim ethanol, be concentrated into the clear paste of relative density 1.25 (80 ℃), the granulation agent.
Sample 2: the thing of getting it filled, add 8 times of decoctings to boil 3 times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction, filtered, filtrate is concentrated into the clear paste that relative density is 1.20 (80 ℃), treat that cream is chilled to 40 ℃, add the equivalent n-butanol extraction 3 times, merge n-butyl alcohol liquid, the clear paste that decompression and solvent recovery to relative density is 1.25 (80 ℃), the granulation agent.。
Sample 3: add 8 times of amount 70% alcohol reflux 3 times, each 1 hour, filter, the clear paste that decompression filtrate recycling ethanol to relative density is 1.20 (60 ℃), add 2 times of water gagings, fully stir 30 minutes, filter, filtrate is concentrated into the clear paste of relative density 1.25 (80 ℃), granulation agent.。
Dichlorodiphenyl Acetate causes the impact of mouse writhing reaction: get healthy mice, male and female half and half, random packet, normal saline group (20.0ml/kg), indomethacin group (0.014g/kg), sample sets (high dose), every group 10, each knob all gavages administration, qd, successive administration 4 days, after last administration 1h, each 0.6% acetum 0.2ml/ that organizes the fresh configuration of equal lumbar injection only, observes and records every mice writhing number of times carry out statistical analysis in writhing response and 30min first.
Result shows, the application's technique (2 groups, sample) can effective rich active ingredient, improved the curative effect of product.
Concrete embodiment
Embodiment 1: Asplenium trchomanes L. 333.3g, Radix cynanchi wilfordii 333.3g
Above two flavor medical materials, add 8 times of decoctings to boil 3 times, and 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction, filtered, filtrate is concentrated into the clear paste that relative density is 1.20 (80 ℃), treats that cream is chilled to 40 ℃, adds the equivalent n-butanol extraction 3 times, merge n-butyl alcohol liquid, the clear paste that decompression and solvent recovery to relative density is 1.25 (80 ℃), add 950g sucrose, mix homogeneously, granulate, drying, granulate obtains granule, a 15g, 2-3 time on the one.
Embodiment 2: Asplenium trchomanes L. 333.3g, Radix cynanchi wilfordii 333.3g
Above two flavor medical materials, add 8 times of decoctings to boil 3 times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.20 (80 ℃), treats that cream is chilled to 40 ℃, add the equivalent n-butanol extraction 3 times, merge n-butyl alcohol liquid, the clear paste that decompression and solvent recovery to relative density is 1.25 (80 ℃), drying under reduced pressure, pulverize, and adds the magnesium stearate of appropriate amount of starch and 0.2%, mix homogeneously, fill, obtain capsule.
Embodiment 3: Asplenium trchomanes L. 333.3g, Radix cynanchi wilfordii 333.3g
Above two flavor medical materials, add 8 times of decoctings to boil 3 times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.20 (80 ℃), treats that cream is chilled to 40 ℃, add the equivalent n-butanol extraction 3 times, merge n-butyl alcohol liquid, the clear paste that decompression and solvent recovery to relative density is 1.25 (80 ℃), drying under reduced pressure, pulverize, and adds in right amount and can press starch, mix homogeneously, tabletting obtains tablet.
Embodiment 4: Asplenium trchomanes L. 333.3g, Radix cynanchi wilfordii 333.3g
Above two flavor medical materials, add 8 times of amount 70% alcohol reflux 3 times, each 1 hour, filter, the clear paste that decompression filtrate recycling ethanol to relative density is 1.20 (60 ℃), add 2 times of water gagings, fully stir 30 minutes, filter, filtrate decompression is concentrated into 800ml, add 100g sucrose and 2g sorbic acid, add water to 1000ml, mix homogeneously, packing, sterilizing, obtain oral liquid.
Claims (6)
1. the preparation method of a stomach Shu Xin preparation, it is characterized in that: it is prepared from as follows by Asplenium trchomanes L. 333.3g, Radix cynanchi wilfordii 333.3g and adjuvant: the thing of getting it filled adds 8 times of decoctings to boil 3 times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction, filter, filtrate is 1.20 clear paste while being concentrated into 80 ℃ of relative densities, treats that cream is chilled to 40 ℃, clarification, add adjuvant, make oral formulations.
2. according to the preparation method of stomach Shu Xin preparation claimed in claim 1, it is characterized in that: described oral formulations refers to capsule, granule, tablet.
3. according to the preparation method of stomach Shu Xin preparation claimed in claim 2, it is characterized in that: the thing of getting it filled, add 8 times of decoctings to boil 3 times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction, filter, filtrate is 1.20 clear paste while being concentrated into 80 ℃ of relative densities, treats that cream is chilled to 40 ℃, add the equivalent n-butanol extraction 3 times, merge n-butyl alcohol liquid, decompression and solvent recovery is 1.25 clear paste during to 80 ℃ of relative densities, adds 950g sucrose, mix homogeneously, granulate, drying, granulate obtains granule.
4. according to the preparation method of stomach Shu Xin preparation claimed in claim 2, it is characterized in that: the thing of getting it filled, add 8 times of decoctings to boil 3 times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction, filter, and filtrate is 1.20 clear paste while being concentrated into 80 ℃ of relative densities, treat that cream is chilled to 40 ℃, add the equivalent n-butanol extraction 3 times, merge n-butyl alcohol liquid, decompression and solvent recovery is 1.25 clear paste during to 80 ℃ of relative densities, drying under reduced pressure, pulverize, add the magnesium stearate of appropriate amount of starch and 0.2%, mix homogeneously, fill, obtain capsule.
5. according to the preparation method of stomach Shu Xin preparation claimed in claim 2, it is characterized in that: the thing of getting it filled, add 8 times of decoctings to boil 3 times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction, filter, filtrate is 1.20 clear paste while being concentrated into 80 ℃ of relative densities, treats that cream is chilled to 40 ℃, add the equivalent n-butanol extraction 3 times, merge n-butyl alcohol liquid, decompression and solvent recovery is 1.25 clear paste during to 80 ℃ of relative densities, drying under reduced pressure, pulverize, add in right amount and can press starch, mix homogeneously, tabletting obtains tablet.
6. according to the preparation method of stomach Shu Xin preparation claimed in claim 2, it is characterized in that: add 8 times of amount 70% alcohol reflux 3 times, each 1 hour, filter, decompression filtrate recycling ethanol, to the clear paste that 60 ℃ of relative densities are 1.20, adds 2 times of water gagings, fully stir 30 minutes, filter, filtrate decompression is concentrated into 800ml, add 100g sucrose and 2g sorbic acid, add water to 1000ml, mix homogeneously, packing, sterilizing, obtain oral liquid.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108051553A (en) * | 2017-12-29 | 2018-05-18 | 武汉轻工大学 | A kind of protectant screening technique of intestines function of piglings |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102872179A (en) * | 2012-10-23 | 2013-01-16 | 贵州百花医药股份有限公司 | Method for preparing Wei shuxin preparation |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102872179A (en) * | 2012-10-23 | 2013-01-16 | 贵州百花医药股份有限公司 | Method for preparing Wei shuxin preparation |
Non-Patent Citations (1)
| Title |
|---|
| 中华人民共和国国家药品监督管理局发布: "《国家食品药品监督管理局国家药品标准 国家中成药标准汇编内科脾胃分册》", 1 December 2002, article "胃舒欣颗粒", pages: 442-444 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108051553A (en) * | 2017-12-29 | 2018-05-18 | 武汉轻工大学 | A kind of protectant screening technique of intestines function of piglings |
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