CN103492041B - Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly - Google Patents
Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly Download PDFInfo
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- CN103492041B CN103492041B CN201280020712.9A CN201280020712A CN103492041B CN 103492041 B CN103492041 B CN 103492041B CN 201280020712 A CN201280020712 A CN 201280020712A CN 103492041 B CN103492041 B CN 103492041B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0209—Multiple bag systems for separating or storing blood components
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0209—Multiple bag systems for separating or storing blood components
- A61M1/0218—Multiple bag systems for separating or storing blood components with filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0429—Red blood cells; Erythrocytes
Abstract
A portable assembly for processing red blood cells RBCs including a disposable blood collection set including a blood bag, an anaerobic storage bag and an oxygen and/or oxygen and carbon dioxide depletion device disposed between the blood collection bag and anaerobic storage bag. The portable assembly further provides for a gas circulation device in fluid communication with the oxygen or oxygen and carbon dioxide depletion device, The gas circulation device includes a pressure source that is able circulate flushing gas through the depletion device as RBCs pass from the blood collection bag, through the depletion device and into the anaerobic storage bag.
Description
Background of invention
1. technical field
Present disclosure is related to portable blood handle manifold assembly.More specifically, present disclosure is related to for blood
It is used for when storing and/or preparing to receiver's blood transfusion removing the oxygen and/or carbon dioxide in leukocyte and consumption blood
Portable blood handle manifold assembly.
2. background technology
The supply of liquid blood is now subjected to the restriction of the stocking system used in traditional blood storage practice.Use
Current system, stored blood as packaging hemocyte preparation in temperature (i.e. 1 DEG C to 6 DEG C) cold preservation about 42 above freezing
Lost efficacy after it.Erythrocyte (RBC) may coagulation from whole blood, separate with liquid blood component (blood plasma).The blood losing efficacy can not
Using and need abandon.
Because the unstable, emergency of donations and other factors are it may occur that the periodic shortages of blood.Blood supply
Logistics impact with distribution is military (during especially fighting), and remote hospital or medical facilities make blood treatment or blood transfusion non-
Often difficult.Therefore, it is required to promptly prepare the RBC for storing or transfuse blood in far zone.
The storage of frozen blood is it is known in the art that but such frozen blood has limitation.For many years, for spy
Determine the blood of high request and infrequent types, blood bank and army are using frozen blood.However, frozen blood is difficult to locate
Reason.Frozen blood must be defrosted, and this makes frozen blood be not suitable for emergency.Once blood is defrosted, it is necessary
Used in 24 hours.No. 6,413,713 United States Patent (USP) of Serebrennikov is related to storage at a temperature of below 0 DEG C
The method of blood.
No. 4,880,786 U.S. of No. 4,769,318 United States Patent (USP) and Sasakawa et al. of Hamasaki et al.
Patent relates to the preservation of blood and the interpolation solution of activation.No. 5,624,794 United States Patent (USP) of Bitensky et al.,
No. 6,162,396 United States Patent (USP) of Bitensky et al. and No. 5,476,764 United States Patent (USP) are related to red under anaerobic conditions
The storage of cell.No. 5,789,151 United States Patent (USP) of Bitensky et al. is related to blood storage and adds solution.
Interpolation solution for blood preseration and activation known in the state of the art.For example, after cold preservation, (i.e. 4 DEG C) face blood transfusion
Before or for extending storage, Rejuvesol (is purchased from enCyte before freezing (i.e. using glycerol at -80 DEG C)
Corp., Braintree, MA) it is added in blood.It is cold that No. 6,447,987 United States Patent (USP) of Hess et al. is related to human red blood cell
The additive solution hidden.
According to prior art, need to remove when preparing for before blood transfusion or for anaerobic storage leukocyte and oxygen and/
Or the portable and cost-effective apparatus and method of the preparation of the RBC of carbon dioxide.
Content of the invention
Therefore, this disclosure provides can before blood transfusion or for storing further in oxygen-free environment from
The system of deoxygenation and/or carbon dioxide and/or leukocyte is gone in RBC.
The present disclosure also provides for the system before blood transfusion or for the RBC storing further in oxygen-free environment
Standby system and method.
Another object is that of present disclosure provides independent portable system, and it has oxygen or oxygen/carbon dioxide-depleted
(oxygen/carbon dioxide depletion, OCDD) device, described device goes deoxygenation from the RBC by this device
Or oxygen and/or carbon dioxide.OCDD device is co-operated with gas exchange systems, and gas is pumped into by described gas exchange systems
In OCDD device, by OCDD device, RBC first passes around oxygen or oxygen/carbon dioxide-depleted (OCDD) device with from such RBC
In remove deoxygenation or oxygen/carbon dioxide.RBC thus consumes oxygen or oxygen/carbon dioxide and being deposited in blood storage bag and is used for
The storage extending or the storage before blood transfusion.
A further object for present disclosure is to provide the independent portable system that gas pumps into this device, by this dress
Put, RBC is through leukocyte depletion filtration device and oxygen and/or carbon dioxide-depleted (OCDD) device with respectively from this RBC
Except leukocyte and oxygen or oxygen/carbon dioxide.RBC does not thus have leukocyte and consumes oxygen or oxygen/carbon dioxide, and is sunk
Amass storage or the storage before blood transfusion being used for extending in blood storage bag.
A further object of present disclosure is to provide independent portable system, this system make oxygen depletion air and/or
The air that carbon dioxide is adjusted or noble gas mixtures cycle through OCDD device to remove this from the RBC flow through filter
The gas of sample, as the preparation of anaerobic storage or blood transfusion.Such system is receiving rich in oxygen and/or titanium dioxide from OCDD device
Comprise oxygen sensor, carbon dioxide sensor between the inlet manifold of the air of carbon or noble gases and outlet manifold and/or divide
Pressure sensor.Sensor monitoring and adjust from outlet manifold receive air or noble gas mixtures oxygen and/or two
The level of carbonoxide, and monitor the oxygen and carbon dioxide partial pressure through air filtration body being pumped back to OCDD device.
A further object of present disclosure is to provide independent portable system, and this system reduces leukocyte and makes oxygen
And/or the air of carbon dioxide regulation or noble gas mixtures cycle through OCDD device to remove such gas from RBC
Body, as the preparation of anaerobic storage or blood transfusion.Such system comprise between inlet manifold and outlet manifold oxygen sensor, two
Oxidation carbon sensor and/or partial pressure sensor, described inlet manifold receives the sky rich in oxygen and/or carbon dioxide from OCDD device
Gas or noble gas mixtures, described outlet manifold makes oxygen and/or the air of carbon dioxide-depleted or noble gas mixtures return
It is back to OCDD device.Sensor monitoring and adjust in outlet manifold receive gas in oxygen and/or carbon dioxide level, and
Monitoring is pumped back to the oxygen and carbon dioxide partial pressure of the gas of OCDD device.
Comprise the portable components for processing erythrocyte RBC of disposable blood liquor collecting device, described assembly comprises blood
Bag, anaerobic reservoir bag and be arranged on oxygen between blood collection bag and anaerobic reservoir bag and/or oxygen and carbon dioxide-depleted dress
Put.This portable components also provides the gas-recycling plant being in fluid communication with oxygen or oxygen and carbon dioxide depletion device, this gas
Circulating device comprises pressure source, and when RBC enters anaerobic reservoir bag from blood collection bag through consumer, this pressure source can
Flushing gas is made to cycle through consumer.
For processing the portable components of erythrocyte (RBC), comprise oxygen or oxygen and carbon dioxide-depleted (OCDD) device.Should
OCDD device comprises the filter cylinder with entrance and exit and setting is used between inlet and outlet transporting RBC and is filled by OCDD
The multiple doughnuts put.Multiple doughnuts are by continuous space cincture.This portable components comprises with OCDD device fluid even
Logical gas exchange device.This gas exchange device comprises to make flushing gas cycle through continuous space and from process
The pressure source of deoxygenation and/or carbon dioxide is removed in the RBC of OCDD device.
These and the other purposes of the present invention and advantage and its counterpart are passed through described herein and appended
Claim in the method for the present invention that presents and compositionss realizing.
Brief description
Fig. 1 a shows the Portable blood liquid treating system according to present disclosure；
Fig. 1 b shows the alternative embodiment of present disclosure, wherein, is processed using load sensor (load cell)
Erythrocyte；
Fig. 1 c shows the OCDD device being connected directly to processing system of the embodiment of Fig. 1 b；
Fig. 1 d shows the collection system comprising flow regulator of the embodiment according to Fig. 1 b；
Fig. 1 e shows the collection system comprising leukocyte depletion filtration device with OCDD device；
Fig. 2 a to Fig. 2 c shows the leukocyte depletion filtration being included in OCDD device of the embodiment according to Fig. 1 e
Device；
Fig. 2 d shows the OCDD device of the embodiment of Fig. 1 a；
Fig. 3 shows the OCDD device according to another embodiment of present disclosure, and it has OCDD in overall structure
Device, leukocyte depletion filtration device and plasma separating unit.
Specific embodiment
With reference to Fig. 1, show independent blood processing system and add note using reference 10 for it.System 10
Comprise shell 15 and support blood collecting and consumption system 100 (hereinafter referred to as " collection system 100 ").Collection system
100 comprise blood bag 200, leukocyte depletion filtration device 300, oxygen and/or carbon dioxide-depleted (OCDD) device 400 and anaerobic storage
Bag 600.Device 400 exhaust can oxygen and carbon dioxide from exhausting oxygen from the gas of RBC or as an alternative.Collection system 100
Be suspended at system 10 internal so that the position possibly remote from standard hospital device or clinical setting can easily move with
And transport blood preparation process.The direction of system 100 allows the RBC in blood bag 200 to flow to anaerobic storage under gravity
Bag 600.Although showing single collection system 100, however, the support 12 of shell 15 can support up to is equal to or more than 10
Individual such processing system.Shell 15 comprises gas-recycling plant, and described gas-recycling plant comprises such as pump 30 or suction dress
Put the pressure source of (vacuum) or pressurizing vessel, valve/pressure regulator 40 and gas is circulated and through OCDD
The miscellaneous part being further discussed of device 400.Entrance 410 and outlet 415 (Fig. 2 d) are respectively connecting to pipe 427 and pipe
426.
Collection system 100 comprises to accommodate the blood bag 200 of the RBC collecting from whole blood.Generally, using traditional method
Collect whole blood from donor, and process whole blood with separated plasma and RBC using centrifuging.Blood bag 200 is that the blood of standard is received
Collection bag.RBC is collected in the blood bag 200 that may comprise additive.The interpolation solution of such as OFAS3 comprises adenine, Fructus Vitis viniferae
Sugar, Mannitol, NaH2PO4And optionally comprise NaCl and/or NH4Cl.Interpolation solution O FAS3 preferably comprises has following scope
Composition：The glucose of the adenine of about 0.5mmol/L to 4.0mmol/L, about 50mmol/L to 150mmol/L, about 20mmol/
The NaH of the NaCl of the Mannitol of L to 70mmol/L, about 0mmol/L to 100mmol/L, about 2mmol/L to 20mmol/L2PO4With
And the NH of about 0mmol/L to 30mmol/L4Cl.Preferably, OFAS3 has about 5.5 to 7.5 adjusted pH value and comprises
The NaH of the NaCl of the glucose of the adenine of about 2mmol/L, about 110mmol/L, about 55mmol/L and about 12mmol/L2PO4, with
And about 6.5 adjusted pH value.Can also within the system using such as SAGM, PAGG-SM, AS-1, AS-3, AS-5,
The additive of SOLX, MAPS, PAGG-GM or ratify any additive for blood storage.
The RBC being contained in blood bag 200 flows to leukocyte depletion filtration device 300 under gravity and flows through OCDD
Device 400.Removing leukocyte (leukoreduction) is the process removing leukocyte from whole blood or RBC.In blood products
Leukocyte can cause immunosuppressive action and patient can be made to be exposed to the risk of the increase of virus and fever, and right
RBC has ill-effect.Remove leukocyte and reduce RBC storage damage, reduce constitutional alloimmunity and reduce defeated
The sum of blood reaction.
The process of the leukocyte of removal RBC preferably occur in after isolating RBC from blood plasma, and can send out
Life is before or after removing oxygen and carbon dioxide from RBC.In both cases, remove leukocyte all should occur
Before RBC is stored in anaerobic reservoir bag 600.
Reference picture 2a, Fig. 2 b and Fig. 2 c, leukocyte depletion filtration device 300 is included in OCDD device 500.OCDD device
500 comprise filter cylinder 505, entrance 510, leukocyte depletion filtration device 520, multiple doughnut 530 and hold multiple doughnuts
530 fibrous framework 540.OCDD device 500 also comprises the outlet 515 passed through for RBC.Leukocyte depletion filtration device 520
Preferably capture the fiber filter material of such leukocyte or similar hair before multiple doughnuts 530 in leukocyte
The filtering material of felt.Fibrous framework 540 support vertical structure multiple doughnuts 530 and can be by the material of such as polyurethane
Material or similar material are made.Whole blood or Red Blood Cells Concentrate (pRBC) flow through filter 520 in removing leukocyte processing procedure.
OCDD device 500 is via entrance 524 and outlet 528 and the gas communication from pump 30.
OCDD filter cylinder 500 comprises about 5000 fibers passing through for RBC.Can using more multifilament or less fiber with
Produce enough surface areas and be used for gas exchange so that oxygen concentration and/or gas concentration lwevel are reduced to aspiration level.In multiple
Hollow fiber 530 is to remove deoxygenation or oxygen and carbon dioxide from RBC, and will be discussed further below.In doughnut
Outside and within filter cylinder 505 the gas compartment 550 around multiple doughnuts 530 and is full of carrier gas.When carrier gas cycles through
During OCDD device 500, the gas permeable materials of multiple doughnuts 530 or porous material enable oxygen and carbon dioxide from
RBC is transferred to such carrier gas.By providing the flushing gas of suitably composition, OCDD device 500 consumes O2And CO2, or O2, or
Only CO2, or there is specified level CO2O2.It is to RBC or blood will not to be subject to be applied to the gas being consumed OCDD device
Any noble gases that person damages, such as Ar, He, N2、Ar/CO2、He/CO2Or N2/CO2.
RBC flows into OCDD device 500 to be consumed oxygen or oxygen and carbon dioxide.OCDD device 500 is at 37 DEG C by RBC blood
Lactoferrin oxygen saturation levels decrease below 3%, and carbon dioxide partial pressure is decreased below 50 supports.OCDD device 500 be from
Oxygen and carbon dioxide is removed to extend the shelf life of such RBC and to promote combination oxygen and the titanium dioxide most preferably transfused blood in RBC
Carbon filter.OCDD device 500 is used in conjunction with and comprises the embodiment phase with Fig. 1 a with the shell 115 of Fig. 1 e and support 12
Same part.
As an alternative, as shown in Figure 2 d, OCDD device 400 does not comprise to remove leukocyte ability and only can be from therethrough
Oxygen or oxygen and carbon dioxide is consumed in RBC.Fig. 2 d shows OCDD device 400, its have the entrance 410 of the entrance for RBC,
The outlet 415 passed through for RBC and multiple fiber 430, such RBC by the plurality of fiber 430 go deoxygenation and/
Or carbon dioxide.OCDD device 400 also comprises the ingate 424 of flushing gas and is used for flushing gas exit hole
428 and multiple spaces 450 of multiple fibers 430 within around filter cylinder 405, the gas exchange from RBC to flushing gas exists
Occur at the plurality of space 450.Pass through the gas of OCDD device 400 via ingate 424, outlet opening 428 and multiple space 450
Body circulation ensure that the oxygen and carbon dioxide partial pressure of the RBC being stored in bag 600 is in being subjected to of the Optimum storage for RBC
Level.
Referring again to Fig. 1 a, shell 15 comprises inlet manifold 20, pump 30, outlet manifold 60 and inlet valve/pressure regulator
40.OCDD filter cylinder 400 passes through pipe 27 and 13 or be directly connected to part 128 and 124 (Fig. 1 c) are respectively connecting to inlet manifold 20 He
Outlet manifold 60.It is provided with the first oxygen/carbon dioxide sensor 50 and the second oxygen/bis- between inlet manifold 20 and outlet manifold 60
Oxidation carbon sensor 90.System 10 may be connected to AC socket (AC outlet) or other power supplys for pump operation 30.Alternative
Ground, system 10 can connect to the remote operated battery for system 10.
Shell 15 comprises disposable or reusable adsorbent filter cylinder 75, described adsorbent filter cylinder 75 be arranged on into
To purify air or the noble gas mixtures through OCDD device 400 between mouth manifold 20 and outlet manifold 60.Adsorbent is filtered
Cylinder 75 is iron-based or other inorganic compound that preferably can physically or chemically adsorb oxygen or oxygen/carbon dioxide
And/or the big filter cylinder of organic compound.Adsorbent filter cylinder 75 comprises oxygen and/or carbon dioxide absorber 76.As big adsorbent
Bag (large sorbent pack) or the alternative of organic compound and inorganic compound, can set by using separating for gas
The membrane filter (membrane filter as found in Nitrogen Generator System) of meter comes from the sky rich in oxygen and carbon dioxide
Oxygen and carbon dioxide is removed in gas or noble gas mixtures.Outside deoxygenation or oxygen/carbon dioxide absorber 76, adsorbent filter cylinder
75 also comprise active carbon filter 78 to adsorb the volatile matter being produced by oxygen or oxygen/carbon dioxide absorber.Active carbon filter
78 also comprise HEPA filter to remove any microgranule.
System 10 also comprises multiple sterilizing filter sensor clusters 70,80 and 85.Sterilizing filter sensor cluster 70
It is arranged between pipe 23 and inlet manifold 20.Sterilizing filter sensor cluster 80 is arranged between outlet manifold 60 and pipe 27.
Filter 70 and filter 80 catch the air-flow that can enter between each pipe and manifold and damage the filtration of RBC and/or net
Any pathogen changed and/or microgranule.Filter monitor in filter sensors assembly 70 and filter sensors assembly 80
The oxygen and carbon dioxide partial pressure level of single OCDD device 400 (or 500).Sterilizing filter 85 is arranged on the outside portion of shell 15
Divide and inlet valve pressure regulator 40 between.Sterilizing filter sensor cluster 85 monitoring enters the gas of pump 30.Filter passes
Pathogen between the filters trap system 10 of sensor assembly 85 and surrounding air or noble gas mixtures and microgranule and
The level of oxygen, carbon dioxide, temperature and pressure and humidity can be sensed.Filter sensors assembly 70,80 and 85 also functions to
The effect of sensor and connecting with controller 35.Controller 35 is monitored and controlled oxygen and two using predetermined set point programming
The concentration of carbonoxide and the gross pressure of flow, temperature, humidity and admixture of gas.If level is inappropriate, such as lamp or
The alarm signal of alarm clock notifies operator should change adsorbent filter cylinder, sterilizing filter or HEPA filter.
Shell 15 comprises caster 25 to allow movement and the placement of system 10.System 10 also comprise big adsorbent filter cylinder 75 or
Hollow fiber gas separation module.
As shown in Figure 1a, in operation, RBC directly or via leukocyte depletion filtration device flows into OCDD from collecting bag 200
Filter cylinder.Make flushing gas cycle through OCDD filter cylinder 400 simultaneously.Flow to adjusting through oxygen or oxygen/carbon dioxide of OCDD filter cylinder 400
Gas conveyed by pipe 27, the oxygen-enriched or oxygen-enriched/carbon dioxide from OCDD filter cylinder 400 is conveyed by pipe 23.Pipe 23 connects
To inlet manifold 20, pipe 27 connects to outlet manifold 60.Pipe 23 is connected to entrance discrimination by sterilizing filter sensor cluster 70
Pipe.Similarly, outlet manifold 60 is connected to pipe 27 by sterilizing filter 80.
Oxygen-enriched air or oxygen-enriched noble gas mixtures via pipe 23 after OCDD device 400 is out, such
Air or noble gas mixtures are received at inlet manifold 20, and are pumped through sensor 50 via pump 30.Pump 30
Run to maintain the air-flow by system 10.Pump 30 is preferably the electric drive pump adjusting pressure and flowing.Pump 30 connects to valve
40, valve 40 preferably receives the surrounding air being in ambient pressure or noble gas mixtures or is in the lazy of the pressure of lifting
The check valve of property gas and pressure regulator.Sensor 50 and sensor 90 measurement oxygen and carbon dioxide partial pressure, except partial pressure
In addition, temperature, flow velocity, total pressure and the humidity of whole portable components are also measured.Air or noble gases are in filter cylinder 75
It is cleaned and is back to OCDD 400 to continue before flowing into anaerobic reservoir bag 600 in such RBC to consume RBC.
Fig. 1 b to Fig. 1 d shows the alternative embodiment of shell 115.Shell 115 comprises less gas exchange part,
As shell 15.That is, shell 115 also comprises to be included in inlet manifold 20 within shell 115, pump 30, outlet manifold 60
With inlet valve/pressure regulator 40.Shell 115 also comprises the load sensor 6 connecting to bag 200 and flow control valve 470.Negative
Lotus sensor 6 measures the Unit Weight in bag 200 and the mass change in bag is conveyed to controller 35, controller 35 and stream
Adjustable valve 470 communicates to monitor the flow of the RBC by OCDD device 400.By monitoring the change of the quality of RBC in bag 200
Change, oxygen or oxygen and carbon dioxide can be sufficiently removed with the RBC guaranteeing to stay in OCDD device 400 with regulating valve 470.Control
Device 35 and load sensor 6, flow control valve 470 and oxygen saturation sensor 475 telecommunication.Oxygen saturation sensor 475 is surveyed
Oxygen saturation levels in amount RBC.Controller 35 receives the signal of instruction oxygen saturation levels and transfers sending signal to adjust
Rectification adjustable valve 470 is to guarantee sufficient oxygen consumption level in RBC.If dry bag 200 (Fig. 1 b) can connect to shell 115,
Although and illustrate only 1 flow control valve 470, if dry bag 200 all can similarly be equipped with flow control valve 470.Outward
Shell 115 has outer surface, and OCCD device 400 can be connected directly to this outer surface via coupling (coupling).As Fig. 1 b extremely
Shown in Fig. 1 d, by configuring OCDD device 400 so that it is connected directly to shell 115 via coupling 124 and coupling 128,
Eliminate the demand for the pipe in the embodiment of Fig. 1 a.The configuration of shell 115 can also with comprise remove leukocyte ability
Device 500 be used together.
With reference to Fig. 3, multi-functional OCDD device 700 is combination leukocyte depletion filtration device 710, OCDD device 720 and blood plasma
The combination of separator 730.Multi-functional OCDD device 700 eliminates and carries out detached needs to the whole blood being received from donor, should
Whole blood is separated using centrifuge at present.By these three devices are combined into single assembly, eliminate for independent centrifuge
The needs of the device of this high cost and heaviness.This embodiment comprises to remove leucocyte fraction 710, OCDD device 720 and
Plasma separator 730.Blood plasma flows through port 740 to another collecting bag and is used for further process.Therefore, preferably
In, whole blood can be gathered from donor, leukocyte can be removed, deoxygenation or oxygen and carbon dioxide can be removed, and can remove
Blood plasma and platelet are so that RBC passes through this device.Then so that RBC is deposited in collecting bag 600 and be used for storage or defeated to donee
Blood.Multi-functional OCDD 700 allows whole blood to the rapid conversion of the RBC storing as a part for collection system 100 and system 10
Transfuse blood to store immediately or to donee.
Although present disclosure describes some embodiments in detail, however, it should be understood that existing in present disclosure
Well known by persons skilled in the art change and modifications.Therefore, present disclosure be intended to be included in scope of the present disclosure interior such as
All such substitute that present disclosure is proposed, modifications and variations.
Claims (8)
1. it is used for processing the portable system of erythrocyte (RBC), it comprises：
Gas-recycling plant, described gas-recycling plant provides flushing gas, and can be with one or more oxygen or oxygen and two
Carbonoxide consumer is in fluid communication,
Described gas-recycling plant comprises fluid communication with each other：
Pressure source；
Gas outlet manifold；
First filter sensors assembly；
Second filter sensors assembly；
Sensor；
Gas inlet manifold；With
Controller,
Wherein said pressure source can make flushing gas cycle through described consumer,
Wherein said sensor is selected from oxygen sensor, carbon dioxide sensor and combinations thereof, and described sensor comprises partial pressure
Sensor, and
Wherein said flushing gas comprises Ar, He, N2、Ar/CO2、He/CO2Or N2/CO2Or their combination in any.
2. portable system according to claim 1, it also comprises to accommodate the shell of described gas-recycling plant, wherein,
Described shell also comprises to be arranged between described pressure source and described gas outlet manifold for removing from described flushing gas
Oxygen or the adsorbent of oxygen and carbon dioxide.
3. portable system according to claim 2, wherein said sensor comprise to be arranged on described pressure source with described
The first sensor comprising the first partial pressure sensor between adsorbent and be arranged on described adsorbent and described gas outlet discrimination
The second sensor comprising the second partial pressure sensor between pipe, wherein said sensor detects oxygen or two in described flushing gas
The level of carbonoxide.
4. portable system according to claim 1, it is one or more negative that it also comprises to connect with described controller
Lotus sensor and one or more flow control valve, wherein said one or more flow control valves are arranged to control
RBC is by one or more oxygen or oxygen and carbon dioxide depletion device flowing and one or more are negative
Lotus sensor is arranged to measure the load of the RBC of collection in blood bag.
5. portable system according to claim 4, wherein, described controller in response to from one or more
The signal of load sensor passes on the signal of the flowing limiting or promoting RBC to pass through one or more flow control valves.
6. portable system according to claim 4, its also comprise to measure flow through one or more oxygen or
Oxygen saturation levels in the RBC of oxygen and carbon dioxide depletion device the oxygen saturation sensor connecting with described controller,
Wherein, described controller passes on signal to limit or to promote RBC to pass through described one to one or more flow control valves
The flowing of individual or more flow control valves.
7. portable system according to claim 1, wherein, described pressure source is selected from pump, aspirator or pressurizing vessel.
8. portable system according to claim 1, it also comprises the 3rd filter sensors assembly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611127102.5A CN107096081B (en) | 2011-03-28 | 2012-03-28 | For using the method and system of inert carrier gas and manifold component removal oxygen and carbon dioxide in red blood cell blood treatment process |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161468377P | 2011-03-28 | 2011-03-28 | |
| US61/468,377 | 2011-03-28 | ||
| PCT/US2012/030930 WO2013022491A1 (en) | 2011-03-28 | 2012-03-28 | Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201611127102.5A Division CN107096081B (en) | 2011-03-28 | 2012-03-28 | For using the method and system of inert carrier gas and manifold component removal oxygen and carbon dioxide in red blood cell blood treatment process |
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| CN103492041A CN103492041A (en) | 2014-01-01 |
| CN103492041B true CN103492041B (en) | 2017-02-08 |
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| CN201280020712.9A Active CN103492041B (en) | 2011-03-28 | 2012-03-28 | Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly |
| CN201611127102.5A Active CN107096081B (en) | 2011-03-28 | 2012-03-28 | For using the method and system of inert carrier gas and manifold component removal oxygen and carbon dioxide in red blood cell blood treatment process |
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| EP (1) | EP2691160A4 (en) |
| JP (2) | JP6034362B2 (en) |
| CN (2) | CN103492041B (en) |
| AU (1) | AU2012294890B2 (en) |
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| WO (1) | WO2013022491A1 (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9199016B2 (en) | 2009-10-12 | 2015-12-01 | New Health Sciences, Inc. | System for extended storage of red blood cells and methods of use |
| US11284616B2 (en) | 2010-05-05 | 2022-03-29 | Hemanext Inc. | Irradiation of red blood cells and anaerobic storage |
| WO2012027582A1 (en) | 2010-08-25 | 2012-03-01 | New Health Sciences | Method for enhancing red blood cell quality and survival during storage |
| PT2635114T (en) | 2010-11-05 | 2020-06-16 | New Health Sciences Inc | Irradiation of red blood cells and anaerobic storage |
| US9067004B2 (en) | 2011-03-28 | 2015-06-30 | New Health Sciences, Inc. | Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly |
| ES2923571T3 (en) | 2011-08-10 | 2022-09-28 | Hemanext Inc | Integrated leukocyte, oxygen and/or CO2 filtering and plasma separation device |
| AU2014223165B2 (en) | 2013-02-28 | 2017-04-13 | Hemanext Inc. | Gas depletion and gas addition devices for blood treatment |
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| CN101039737A (en) * | 2004-10-15 | 2007-09-19 | 赛尔格有限责任公司 | A membrane contactor and method of making the same |
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