JPH06254152A - Blood plasma changing device - Google Patents
Blood plasma changing deviceInfo
- Publication number
- JPH06254152A JPH06254152A JP5042404A JP4240493A JPH06254152A JP H06254152 A JPH06254152 A JP H06254152A JP 5042404 A JP5042404 A JP 5042404A JP 4240493 A JP4240493 A JP 4240493A JP H06254152 A JPH06254152 A JP H06254152A
- Authority
- JP
- Japan
- Prior art keywords
- plasma
- blood
- purified
- weight
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は、自己の血液中の成分が
病因となっている患者より、その有害物質を含む血漿を
採取し、有害物質を除去して、再び患者に返還する血漿
浄化療法などに使用される血漿交換装置に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to plasma purification in which plasma containing a harmful substance is collected from a patient whose component is in the blood of his own, and the harmful substance is removed and returned to the patient again. The present invention relates to a plasmapheresis device used for therapy and the like.
【０００２】[0002]
【従来の技術】これらの疾患としては、免疫が関与する
腎疾患、膠原病、血漿蛋白異常疾患、コレステロールの
代謝異常疾患、肝疾患、薬物中毒などが知られている。
その治療法として、有害物質を含む血漿を分離除去し、
新鮮凍結血漿や、アルブミン製剤等を置換液として補充
する、いわゆる血漿交換療法が行われ、その臨床的効果
が確認されている。しかし、血漿交換療法では、患者の
血漿を置換液と交換するものであるため、多量の置換液
が必要となるという問題を有している。また、アルブミ
ン製剤等をを置換液として、用いる場合は必要とされる
血漿成分をすべて補えるものではなく、一方、新鮮凍結
血漿を置換液として用いる場合には他人の血漿を原料と
しているので、肝炎や後天性免疫不全症候群（ＡＩＤ
Ｓ）への感染、アレルギー等の発症の問題もある。2. Description of the Related Art As these diseases, renal diseases associated with immunity, collagen diseases, plasma protein abnormal diseases, cholesterol metabolic abnormal diseases, liver diseases, drug poisoning and the like are known.
As a treatment method, plasma containing harmful substances is separated and removed,
So-called plasma exchange therapy, in which fresh frozen plasma, albumin preparations, etc. are replenished as replacement fluid, has been performed, and its clinical effect has been confirmed. However, the plasma exchange therapy has a problem that a large amount of the replacement liquid is required because the plasma of the patient is replaced with the replacement liquid. In addition, when an albumin preparation or the like is used as a replacement liquid, it does not supplement all the necessary plasma components. On the other hand, when fresh frozen plasma is used as a replacement liquid, the plasma of another person is used as a raw material. And acquired immunodeficiency syndrome (AID
There is also the problem of infection with S) and the development of allergies.
【０００３】そこで、患者から病因性物質を含む血漿を
分離し、分離された血漿から病因性物質を除去し、再び
患者に返還する血漿浄化法が行われている。この血漿浄
化療法は、患者からポンプ等により血液を１００ｍｌ／
ｍｉｎ程度の流量で体外に取り出し、この血液を血漿分
離器により血球成分と血漿成分とに分離し、血漿中より
有害物質を除去し、浄化された血漿を血球成分と混合し
て、再び患者に返還するものである。そして、これらの
方法としては、例えば、濾過膜を用いて高分子量物質物
質を除去する方法（特公平４−７００２７）、血漿に塩
析剤等を添加して、溶解度の差から病因性物質を析出分
離除去する溶解度分別法を応用した方法（ＵＳＰ４、３
２１、１９２）、病因性物質に対し特異的な吸着性能を
示す吸着剤を用いて吸着させる方法（ＵＳＰ４、８１
４、０７７）、血漿を冷却し、有害物質を析出し除去す
る方法（ＵＳＰ４、３５０、１５６）が挙げられる。Therefore, a plasma purification method is carried out in which plasma containing a pathogenic substance is separated from a patient, the pathogenic substance is removed from the separated plasma, and the plasma is returned to the patient again. In this plasma purification therapy, 100 ml of blood /
It is taken out of the body at a flow rate of about min, this blood is separated into blood cell components and plasma components by a plasma separator, harmful substances are removed from the plasma, purified plasma is mixed with the blood cell components, and the blood is again delivered to the patient. It will be returned. As these methods, for example, a method of removing a high molecular weight substance using a filtration membrane (Japanese Patent Publication No. 4-70027), a salting out agent or the like is added to plasma, and a pathogenic substance is detected from a difference in solubility. A method applying a solubility fractionation method of separating, separating and removing (USP 4, 3
21, 192), a method of adsorbing a pathogenic substance using an adsorbent having a specific adsorption performance (USP 4,81)
4, 077), and a method of precipitating and removing harmful substances by cooling plasma (USP 4,350, 156).
【０００４】[0004]
【発明が解決しようとする課題】これらの方法は、上記
のように血液を一定流量にて体外循環し、各工程が流体
的に連通して行う、いわゆるｏｎ−ｌｉｎｅ方式により
行われる。しかし、この血漿浄化法では、血液の分離と
分離された血漿の浄化を同時に行うので、施行時におけ
る異常が患者に体外血液循環回路が接続された状態に
て、血漿分離手段、血漿浄化手段の両方に発生する可能
性があること、１００ｍｌ／ｍｉｎ程度の血液流量で血
液を循環して２０ｍｌ／ｍｉｎの血漿流量で浄化を行う
ものとしても、患者の全血漿量の１００％程度を浄化す
るためには、ほぼ２時間程度の時間が必要となり、治療
のために患者を拘束する時間が長いということなどの問
題点を有している。These methods are carried out by a so-called on-line system in which blood is circulated extracorporeally at a constant flow rate as described above and each process is fluidly communicated. However, in this plasma purification method, the separation of blood and the purification of separated plasma are performed at the same time. Therefore, when an abnormality occurs during the procedure, the plasma separation means and the plasma purification means are connected to the patient while the extracorporeal blood circulation circuit is connected. It may occur in both, and even if blood is circulated at a blood flow rate of about 100 ml / min to perform purification at a plasma flow rate of 20 ml / min, about 100% of the total plasma volume of the patient is purified. Requires about 2 hours, and there is a problem that the patient is restrained for a long time for treatment.
【０００５】そこで、本件発明者は、上述の体外血液循
環方式による血漿浄化療法の有する問題点のない、患者
本人から前回の治療の際に採取し、既に浄化済みの血漿
を使用して行う血漿浄化療法を検討した。Therefore, the inventor of the present invention does not have the problems of the above-mentioned plasma purification therapy by the extracorporeal blood circulation system, and the plasma is collected from the patient at the time of the previous treatment and the plasma is already purified. Considered purification therapy.
【０００６】[0006]
【課題を解決するための手段】上記目的を達成するもの
は、患者から採血針を介して全血を採取する採血回路
と、採血される全血に抗凝固剤を添加する抗凝固剤添加
回路と、抗凝固された全血を血漿成分と血球成分に分離
する血漿分離器と、血漿成分を採取する血漿採取容器
と、血球成分に浄化血漿を添加する浄化血漿添加回路
と、血球成分および浄化血漿を患者に採血針から返還す
る返血回路と、血漿採取量を検知する手段と、送液され
た浄化血漿量を検知する手段とを少なくとも有し、血漿
採取量に応じた量の浄化血漿を血球成分に加え患者に返
還するように制御する血漿交換量制御機構を有している
ことを特徴とする単針式血漿交換装置である。そして、
本発明の血漿交換装置によれば、前回の治療の際に採取
し、浄化済みの血漿を患者に変換することにより、血漿
の浄化時における異常が患者に影響することを防止し、
また、血漿浄化に必要な時間を短縮することができる。[Means for Solving the Problems] To achieve the above object, a blood sampling circuit for collecting whole blood from a patient through a blood sampling needle, and an anticoagulant addition circuit for adding an anticoagulant to the whole blood sampled , A plasma separator for separating anticoagulated whole blood into plasma components and blood cell components, a plasma collection container for collecting plasma components, a purification plasma addition circuit for adding purified plasma to blood cell components, and blood cell components and purification At least a blood return circuit for returning plasma from a blood collection needle to a patient, a means for detecting the amount of collected plasma, and a means for detecting the amount of purified plasma that has been delivered, and the amount of purified plasma according to the amount of collected plasma The single-needle plasma exchange apparatus is characterized by having a plasma exchange amount control mechanism for controlling to return to the patient in addition to blood cell components. And
According to the plasmapheresis device of the present invention, by collecting the plasma during the previous treatment and converting the purified plasma into the patient, it is possible to prevent the abnormality during the plasma purification from affecting the patient,
In addition, the time required for plasma purification can be shortened.
【０００７】[0007]
【実施例１】本発明の血漿交換装置の実施例を添付した
図面に基づいて説明する。Embodiment 1 An embodiment of the plasmapheresis device of the present invention will be described with reference to the accompanying drawings.
【０００８】図１は、本発明の血漿交換装置の実施例の
基本構成を示す該略図である。FIG. 1 is a schematic diagram showing the basic construction of an embodiment of the plasmapheresis apparatus of the present invention.
【０００９】図２は、本発明の血漿交換装置の実施例の
血漿交換回路概略図である。FIG. 2 is a schematic diagram of a plasma exchange circuit of an embodiment of the plasma exchange apparatus of the present invention.
【００１０】この血漿交換装置１は、患者から採血針に
より全血を採取するための採血回路と、採取される全血
に血液抗凝固剤を添加するための抗凝固剤添加回路と、
全血を血漿成分と血球成分に分離する血漿分離器と、血
漿成分を採取する血漿採取容器と、血球成分に浄化血漿
を添加するための浄化血漿添加回路と、血球成分および
浄化血漿を患者に採血針から返還するための返血回路と
を少なくとも有している。The plasma exchange apparatus 1 includes a blood collecting circuit for collecting whole blood from a patient with a blood collecting needle, an anticoagulant adding circuit for adding a blood anticoagulant to the collected whole blood,
Plasma separator for separating whole blood into plasma and blood cell components, plasma collection container for collecting plasma component, purified plasma addition circuit for adding purified plasma to blood cell component, and blood cell component and purified plasma for patients And a blood return circuit for returning the blood from the blood collecting needle.
【００１１】そして、図１に示す血漿交換装置では、採
血回路は、採血針２１と、採血容器５と、採血針２１と
採血容器５とを連通する第１送血管２とにより構成され
ている。また、採血容器５と血漿分離器７の血液流入口
とは、第２送血管６により連通している。そして、血漿
分離器７の血球成分流出口と第１送血管２とは、第３送
血管８により連通しており、返血回路を構成している。
そして、血漿分離器７の血漿流出口と血漿採取容器１０
とは、血漿輸送管９により連通している。さらに、浄化
血漿収納容器７５は、輸液手段７２を介して、浄化血漿
輸送管７８により第３送血管８と連通しており、浄化血
漿添加回路を構成している。また、抗凝固剤収納容器４
５は、抗凝固剤輸送管４８により採血容器５と連通して
おり、抗凝固剤添加回路を構成している。In the plasma exchange apparatus shown in FIG. 1, the blood collecting circuit is composed of a blood collecting needle 21, a blood collecting container 5, and a first blood supply tube 2 which connects the blood collecting needle 21 and the blood collecting container 5 to each other. . Further, the blood collection container 5 and the blood inlet of the plasma separator 7 are in communication with each other by the second blood supply vessel 6. The blood cell component outlet of the plasma separator 7 and the first blood supply vessel 2 communicate with each other by the third blood supply vessel 8 to form a blood return circuit.
Then, the plasma outlet of the plasma separator 7 and the plasma collection container 10
And are communicated with each other through the plasma transport tube 9. Further, the purified plasma storage container 75 communicates with the third blood supply vessel 8 via the purified blood plasma transport pipe 78 via the infusion means 72, and constitutes a purified plasma adding circuit. In addition, the anticoagulant storage container 4
5 is connected to the blood collection container 5 by the anticoagulant transport pipe 48 and constitutes an anticoagulant addition circuit.
【００１２】そして、血漿交換装置１は、血漿採取容器
１０の重量を検知する重量検知手段９９と、採血容器５
の重量を検知する重量検知手段５７と、浄化血漿収納容
器７５の重量を検知する重量検知手段１００と、採血回
路により全血を採取し、採取した全血を血漿成分と血球
成分に分離し、血漿成分を血漿採取容器に採取し、かつ
血球成分に浄化血漿を添加して患者に返還する血漿交換
作業を、血漿交換総量が血漿交換設定量に到達するま
で、繰り返して行われるように制御する制御部５９とを
有し、制御部５９は、重量検知手段９９により検知され
る前回までの各回の血漿交換積算量と、重量検知手段５
７により検知される前回までの各回の採血積算量に基づ
き、次回の血漿交換作業における適正採血量を算出し、
その算出値に基づき全血の採取を行い、かつ採漿量に応
じた量の浄化血漿を血球成分に添加し患者に返還するよ
うに制御する血漿交換量制御手段を有している。The plasma exchange apparatus 1 includes a weight detection means 99 for detecting the weight of the plasma collection container 10 and the blood collection container 5.
, A weight detecting means 100 for detecting the weight of the purified plasma container 75, and a blood collecting circuit for collecting whole blood, and separating the collected whole blood into a plasma component and a blood cell component, The plasma exchange work of collecting plasma components into a plasma collection container and adding purified plasma to blood cell components and returning them to the patient is controlled to be repeated until the total amount of plasma exchange reaches the set amount of plasma exchange. The control unit 59 has a control unit 59, and the control unit 59 detects the weight of the plasma exchange integrated amount of each time up to the previous time detected by the weight detection unit 99 and the weight detection unit 5.
Based on the accumulated blood collection amount of each time up to the previous time detected by 7, calculate the appropriate blood collection amount in the next plasma exchange work,
Based on the calculated value, whole blood is collected, and a plasma exchange amount control means is provided for controlling so as to add purified plasma in an amount corresponding to the amount of collected plasma to the blood cell component and return it to the patient.
【００１３】この血漿交換装置によれば、制御部によ
り、次回の血漿交換作業における適正採血量を算出し、
その算出値に基づき全血が採取されるので、目的とする
血漿量を無駄な採血を行う事なく採取し、かつ浄化血漿
と効率よく交換することができる。According to this plasma exchange apparatus, the control unit calculates an appropriate blood collection amount in the next plasma exchange operation,
Since whole blood is collected based on the calculated value, it is possible to collect the target amount of plasma without wasteful blood collection and efficiently exchange it with purified plasma.
【００１４】そして、この血漿交換装置１は、採血容器
収納部４１と、採血容器収納部４１の内部を加圧および
減圧するための減圧・加圧手段５８と、膜型血漿分離器
７と、血漿交換回路の第１送血管２を開閉するための第
１の回路開閉手段１２と、第２送血管６を開閉するため
の第２の回路開閉手段１３と、血漿輸送管９を開閉する
ための第３の回路開閉手段１４と、第３送血管８を開閉
するための第４の回路開閉手段１５と、抗凝固剤輸送管
４８を開閉するための第５の回路開閉手段４６と、浄化
血漿を第３送血管に送液する輸液手段７２と、血漿採取
容器１０の重量を検知する重量検知手段９９と、採血容
器収納部に収納される採血容器５の重量を検知する重量
検知部５７と、浄化血漿収納容器７５の重量を検知する
重量検知手段１００と採血容器収納部４１内部の圧力を
検知するための圧力検知部５５を有している。The blood plasma exchange device 1 includes a blood collection container housing portion 41, a depressurizing / pressurizing means 58 for pressurizing and depressurizing the inside of the blood sampling container housing portion 41, a membrane type plasma separator 7, For opening / closing the first circuit opening / closing means 12 for opening / closing the first blood sending vessel 2 of the plasma exchange circuit, the second circuit opening / closing means 13 for opening / closing the second blood sending vessel 6, and the plasma transport tube 9. The third circuit opening / closing means 14, the fourth circuit opening / closing means 15 for opening / closing the third blood supply vessel 8, the fifth circuit opening / closing means 46 for opening / closing the anticoagulant transport tube 48, and purification. Infusion means 72 for sending plasma to the third blood supply vessel, weight detection means 99 for detecting the weight of the plasma collection container 10, and weight detection unit 57 for detecting the weight of the blood collection container 5 stored in the blood collection container storage part. And a weight detecting means 10 for detecting the weight of the purified plasma container 75. And a pressure detecting portion 55 for detecting the pressure inside the blood collection container housing portion 41 and.
【００１５】血漿交換装置１について、具体的に説明す
ると、減圧・加圧手段５８は、送排気回路５３と、減圧
・加圧切替バルブ５１、５２と、真空ポンプ４３と、リ
ークバルブ５０により構成されている。また、減圧・加
圧手段５８、圧力検知部５５、採血容器の重量検知部５
７、血漿採取容器１０の重量検知部９９、浄化血漿収納
容器の重量検知部１００、輸液手段７２、回路開閉手段
１２、１３、１４、１５、４６はすべて制御部５９に電
気的に接続されている。この制御部５９は、後述する図
５ないし図７のフローチャートに示すように各構成を制
御する。The blood plasma exchange device 1 will be described in detail. The pressure reducing / pressurizing means 58 is composed of an air supply / exhaust circuit 53, pressure reducing / pressurizing switching valves 51, 52, a vacuum pump 43, and a leak valve 50. Has been done. Further, the pressure reducing / pressurizing means 58, the pressure detecting section 55, and the weight detecting section 5 of the blood collecting container
7. The weight detection unit 99 of the plasma collection container 10, the weight detection unit 100 of the purified plasma storage container, the infusion means 72, the circuit opening / closing means 12, 13, 14, 15, 46 are all electrically connected to the control unit 59. There is. The control unit 59 controls each component as shown in the flowcharts of FIGS. 5 to 7 described later.
【００１６】採血容器収納部４１には、減圧・加圧手段
５８が接続されており、この収納部４１内部を加圧およ
び減圧可能となっている。この減圧・加圧手段は、図１
に示すように、送排気回路５３、真空ポンプ４３、２つ
の３ポートバルブ５１、５２により構成されている。こ
の減圧・加圧手段５８は、減圧状態として、−１００〜
−２００ｍｍＨｇを１０ｍｍＨｇごとに設定でき、さら
に加圧状態として、＋５０〜＋２００ｍｍＨｇを１０ｍ
ｍＨｇごとに設定できるように構成されている。そし
て、減圧および加圧状態は、真空ポンプ４３のＯＮ／Ｏ
ＦＦによりほぼ一定圧力を維持し、３ポートバルブ５
１、５２の切替により減圧・加圧状態の切替を行うよう
に構成されている。A depressurizing / pressurizing means 58 is connected to the blood collection container storage section 41, and the inside of the storage section 41 can be pressurized and depressurized. This pressure reducing / pressurizing means is shown in FIG.
As shown in FIG. 5, it is composed of an air supply / exhaust circuit 53, a vacuum pump 43, and two three-port valves 51, 52. This depressurizing / pressurizing means 58, in a depressurized state, is -100
-200 mmHg can be set for every 10 mmHg, and +50 to +200 mmHg is set to 10 m as a pressurized state.
It is configured so that it can be set for each mHg. The depressurized and pressurized conditions are ON / O of the vacuum pump 43.
FF keeps almost constant pressure, 3 port valve 5
It is configured such that the pressure reduction / pressurization state is switched by switching between 1 and 52.
【００１７】そこで、この減圧・加圧手段の作用を、３
ポートバルブ５１、５２の動作状態で説明する。３ポー
トバルブ５１、５２は、オン状態では、通気状態とな
り、オフ状態では、大気解放状態となる。よって、３ポ
ートバルブ５１のみをオン（３ポートバルブ５２をオ
フ）にすれば、真空ポンプ４３の作動により、排気が行
われ、採血容器収納部４１内部が減圧状態となる。逆
に、３ポートバルブ５２のみをオン（３ポートバルブ５
１をオフ）にすれば、真空ポンプ４３の作動により、吸
気が行われ、採血容器収納部４１内部が加圧状態とな
る。Therefore, the operation of this pressure reducing / pressurizing means is
The operation state of the port valves 51 and 52 will be described. The three-port valves 51 and 52 are in a ventilation state when they are on, and are in an atmosphere open state when they are off. Therefore, if only the 3 port valve 51 is turned on (the 3 port valve 52 is turned off), the vacuum pump 43 is operated to evacuate and the inside of the blood collection container storage unit 41 is depressurized. On the contrary, only the 3 port valve 52 is turned on (3 port valve 5
When 1 is turned off), the vacuum pump 43 is actuated to inhale air and the inside of the blood collection container storage unit 41 is put into a pressurized state.
【００１８】また、採血容器収納部４１には、図１に示
すように、内部の圧力を検知するための圧力検知手段５
５が取り付けられている。圧力検知手段としては、拡散
型半導体圧力検知手段が好適に使用される。さらに、採
血容器収納部４１には、図１に示すように、採血容器の
重量検知手段５７、例えば重量センサが設けられてい
る。重量検知手段５７としては、ロードセルが好適に使
用される。Further, as shown in FIG. 1, the blood collection container storage section 41 has a pressure detecting means 5 for detecting the internal pressure.
5 is attached. A diffusion type semiconductor pressure detecting means is preferably used as the pressure detecting means. Further, as shown in FIG. 1, the blood collection container storage portion 41 is provided with a weight detection means 57 for the blood collection container, for example, a weight sensor. A load cell is preferably used as the weight detecting means 57.
【００１９】そして、回路開閉手段１２、１３、１４、
１５、４６は、通常状態において閉塞しているソレノイ
ド・ピンチバルブが好適に使用される。また、輸液手段
７２は停止状態のとき回路を閉塞している。The circuit opening / closing means 12, 13, 14,
A solenoid pinch valve, which is closed in the normal state, is preferably used as 15, and 46. Further, the liquid transfusing means 72 closes the circuit in the stopped state.
【００２０】そして、血漿交換装置１には、血漿採取容
器１０の重量を検出する重量検知手段９９および浄化血
漿収納容器７５の重量を検出する重量検知手段１００が
設けられている。この重量検知手段９９、１００として
は、外部出力電子計量器が好適に使用され、この重量検
知手段９９より血漿採取容器１０の重量が一定の周期で
測定され、その重量変化から血漿採取量が制御部５９で
求められる。また、重量検知部１００より浄化血漿収納
容器７５の重量が一定の周期で測定され、その重量変化
から浄化血漿輸液量が制御部５９で求められる。そし
て、浄化血漿収納容器７５には前回の治療の際に患者本
人から採取し、既に浄化を行った血漿を貯留してある。The plasma exchange apparatus 1 is provided with weight detection means 99 for detecting the weight of the plasma collection container 10 and weight detection means 100 for detecting the weight of the purified plasma storage container 75. An external output electronic measuring instrument is preferably used as the weight detecting means 99 and 100, and the weight of the plasma collection container 10 is measured by the weight detecting means 99 at a constant cycle, and the plasma collection amount is controlled from the change in the weight. Obtained in part 59. In addition, the weight of the purified plasma storage container 75 is measured by the weight detection unit 100 at regular intervals, and the purified plasma transfusion amount is obtained by the control unit 59 from the change in the weight. The purified plasma storage container 75 stores the plasma that has been collected from the patient during the previous treatment and already purified.
【００２１】特に、ここでは図５、図６および図７を参
照して、本発明の血漿交換装置の実施例の動作状況を説
明する。In particular, referring to FIGS. 5, 6 and 7, the operating condition of the embodiment of the plasmapheresis device of the present invention will be described.
【００２２】まず、重量検知手段５７によって採血容器
５の重量（ＮＷ0）の検知が行われる。続いて、抗凝固
剤注入モードとなる。抗凝固剤注入モードでは、リーク
バルブ５０が閉塞状態となり、減圧・加圧切替バルブ５
１が通気状態となり、回路開閉手段４６が開放状態とな
り、さらに真空ポンプ４３が作動し、採血容器収納部４
１内部が減圧状態となり、抗凝固剤収納容器４５より採
血容器５内に抗凝固剤（例えば、ＡＣＤ液）が注入され
る。この抗凝固剤の注入は、重量検知部５７により、採
血容器５の重量（ＮＷN）より、抗凝固剤充填前の採血
容器５の重量（ＮＷ0）を引いた重量が、抗凝固剤設定
重量（Ｗ0）以上（ＮＷN−ＮＷ0≧Ｗ0）に達することが
検知されるまで行われ、上記の状態に達すると、真空ポ
ンプ４３の作動が停止するとともに、回路開閉手段４６
が閉塞状態となり、リークバルブ５０が開放状態とな
り、抗凝固剤の注入モードが終了する。ＮＷN−ＮＷ0≧
Ｗ0に達しないうちは、常に異常が発生しているかを判
断し、異常が発生したと判断された場合は、異常処理を
行う。First, the weight detection means 57 detects the weight (NW 0 ) of the blood collection container 5. Then, the anticoagulant injection mode is set. In the anticoagulant injection mode, the leak valve 50 is closed and the pressure reducing / pressurizing switching valve 5
1 is in a ventilation state, the circuit opening / closing means 46 is in an open state, the vacuum pump 43 is further operated, and the blood collection container storage section 4
The inside of the device 1 is in a reduced pressure state, and the anticoagulant (for example, ACD solution) is injected from the anticoagulant container 45 into the blood collection container 5. In the injection of the anticoagulant, the weight detection unit 57 subtracts the weight (NW 0 ) of the blood sampling container 5 before filling the anticoagulant from the weight (NW N ) of the blood sampling container 5 to set the anticoagulant. The process is performed until it is detected that the weight (W 0 ) or more (NW N −NW 0 ≧ W 0 ) is reached. When the above state is reached, the operation of the vacuum pump 43 is stopped and the circuit opening / closing means 46 is performed.
Is closed, the leak valve 50 is opened, and the anticoagulant injection mode ends. NW N −NW 0 ≧
Before W 0 is reached, it is constantly determined whether an abnormality has occurred. If it is determined that an abnormality has occurred, abnormality processing is performed.
【００２３】続いて、採血モードに移行し、回路開閉手
段１２が開放状態となる。穿刺針２１を患者の静脈に穿
刺すると、静脈圧によって血液が穿刺針２１より送血管
に流入する。そして、リークバルブ５０が閉塞状態、減
圧・加圧切換バルブ５１が通気状態となり、真空ポンプ
４３のＯＮ／ＯＦＦ動作によって採血容器収納部４１内
の圧力は、所定圧力範囲内で減圧状態が維持される。上
記の真空ポンプ４３の作動により、採血容器５内には、
血液が流入する。そして、採血容器５は、重量検知部５
７によりその重量が逐次検知されており、採血容器５の
重量（ＮＷN）が、採血設定重量［Ｗ1＝採血設定重量＋
採血前の採血容器５の重量］以上（ＮＷN≧Ｗ1）に達す
ると、回路開閉手段１２を閉塞し、リークバルブ５０が
開放状態となり、真空ポンプ４３の作動が停止し、バル
ブ５１も大気開放状態となり、採血モードが終了する。
ＮＷN≧Ｗ1に達しないうちは、常に異常が発生している
か判断し、異常が発生したと判断された場合は、異常処
理を行う。Then, the blood collecting mode is entered and the circuit opening / closing means 12 is opened. When the puncture needle 21 is punctured into a patient's vein, blood flows into the blood supply vessel from the puncture needle 21 due to venous pressure. Then, the leak valve 50 is closed, the pressure reducing / pressurizing switching valve 51 is ventilated, and the ON / OFF operation of the vacuum pump 43 keeps the pressure inside the blood collection container storage portion 41 within the predetermined pressure range. It By the operation of the vacuum pump 43 described above,
Blood flows in. The blood collection container 5 has the weight detection unit 5
7, the weight is sequentially detected, and the weight of the blood collection container 5 (NW N ) is the blood collection set weight [W 1 = the blood collection set weight +
When the weight of the blood collection container 5 before blood collection] or more (NW N ≧ W 1 ) is reached, the circuit opening / closing means 12 is closed, the leak valve 50 is opened, the operation of the vacuum pump 43 is stopped, and the valve 51 is also in the atmosphere. The blood collection mode is ended by opening the blood collection mode.
Unless NW N ≧ W 1 is reached, it is always determined whether an abnormality has occurred, and if it is determined that an abnormality has occurred, abnormality processing is performed.
【００２４】次に、少量返血モードとなり、図６のフロ
ーチャート［１］に移行する。この少量返血モードは、
採血終了後、第１送血管２内の血液は、抗凝固剤が添加
されていない状態となっており、このまま放置すると、
第１送血管２の血液が凝固するので、少量返血を行うこ
とにより、この第１送血管２内の血液を患者に返血し、
第１送血管２内に採血容器５中の抗凝固剤が添加された
血液を流入させ、第１送血管２内での血液の凝固を防止
するために行うものである。この少量返血モードでは、
リークバルブ５０が閉塞状態、バルブ５１が大気開放状
態、バルブ５２が通気状態となり、真空ポンプ４３が作
動し、採血容器収納部４１内部を加圧状態とし、このと
きの採血容器５の重量をＮＷ1として記憶し、回路開閉
手段１２を開放状態とする。この少量返血は、少量返血
前の採血容器の重量（ＮＷ1）より採血容器の重量（Ｎ
ＷN）を引いた重量が、少量返血設定重量（Ｗ2）以上
（ＮＷ1−ＮＷN≧Ｗ2）となるまで行われ、上記の設定
重量に達すると、回路開閉手段１２が閉塞状態となり、
少量返血モードが終了する。ＮＷ1−ＮＷN≧Ｗ2に達し
ないうちは、常に異常が発生しているかを判断し、異常
が発生したと判断された場合は、異常処理を行う。Next, the small blood volume returning mode is set, and the flow shifts to the flowchart [1] of FIG. This small blood return mode
After the blood collection is completed, the blood in the first blood supply tube 2 is in a state where no anticoagulant is added, and if left as it is,
Since the blood in the first blood vessel 2 is coagulated, a small amount of blood is returned to return the blood in the first blood vessel 2 to the patient,
This is performed in order to prevent blood from coagulating in the first blood supply tube 2 by causing the blood containing the anticoagulant added in the blood collection container 5 to flow into the first blood supply tube 2. In this small blood return mode,
The leak valve 50 is closed, the valve 51 is opened to the atmosphere, the valve 52 is vented, the vacuum pump 43 is operated, and the inside of the blood collection container storage portion 41 is pressurized, and the weight of the blood collection container 5 at this time is NW. The value is stored as 1 , and the circuit opening / closing means 12 is opened. This small-volume blood return is based on the weight of the blood collection container (NW 1 ) before the small-volume return (NW 1 ).
The weight obtained by subtracting W N ) is repeated until the small blood return set weight (W 2 ) or more (NW 1 −NW N ≧ W 2 ) is reached, and when the set weight is reached, the circuit opening / closing means 12 is in the closed state. Next to
The small blood volume return mode ends. Unless NW 1 −NW N ≧ W 2 is reached, it is constantly determined whether an abnormality has occurred. If it is determined that an abnormality has occurred, abnormality processing is performed.
【００２５】続いて、血漿交換モードに移行する。血漿
交換モードでは、血漿採取作業と返血作業が行われる。
まず、回路開閉手段１３，１４，１５が開放状態とな
り、真空ポンプ４３は少量返血モードから作動が維持さ
れている。このため、採血容器５内部の血液が膜型血漿
分離器７に流入し、膜型血漿分離器７により血漿成分と
血球成分に分離される。血漿成分は、血漿輸送管９を通
り血漿採取容器１０に流入し血漿採取作業が行われる。
一方、返血作業は図７に示される輸液手段制御ルーチン
に移行する。Then, the plasma exchange mode is entered. In the plasma exchange mode, plasma collection work and blood return work are performed.
First, the circuit opening / closing means 13, 14 and 15 are opened, and the vacuum pump 43 is maintained in operation from the small blood volume returning mode. Therefore, the blood in the blood collection container 5 flows into the membrane plasma separator 7 and is separated into the plasma component and the blood cell component by the membrane plasma separator 7. The plasma component flows into the plasma collection container 10 through the plasma transport pipe 9 and the plasma collection work is performed.
On the other hand, the blood return operation shifts to the infusion means control routine shown in FIG.
【００２６】輸液手段制御ルーチンでは、まず採漿タイ
マ＝０であるかの判断が行われる。採漿タイマの初期値
は、例えば３０（ｓ）とし、採漿タイマ≠０の場合に
は、採漿タイマがカウントダウンされる。採漿タイマ＝
０の場合には、重量検知手段９９で検知された血漿採取
容器１０の重量から、制御部５９によって血漿採取量が
求められ、採漿タイマはリセットされる。制御部５９で
は、血漿採取量に基づいて必要量の浄化血漿が血球成分
に合流するように輸液手段７２を制御する。In the liquid transfusing means control routine, it is first judged whether or not the sampling timer = 0. The initial value of the sampling timer is, for example, 30 (s), and when the sampling timer ≠ 0, the sampling timer is counted down. Sampling timer =
In the case of 0, the plasma collection amount is obtained by the control unit 59 from the weight of the plasma collection container 10 detected by the weight detection means 99, and the plasma sampling timer is reset. The control unit 59 controls the infusion means 72 so that the required amount of purified plasma merges with the blood cell component based on the amount of collected plasma.
【００２７】続いて、輸液タイマ＝０であるかの判断が
行われる。輸液タイマの初期値は例えば１２０（ｓ）と
し、輸液タイマ≠０の場合は、輸液タイマがカウントダ
ウンされる。輸液タイマ＝０の場合は、重量検知手段１
００で逐次検知されている浄化血漿収納容器７５の重量
から、制御部５９によって浄化血漿輸液量が求められ、
輸液速度と血漿採取速度の釣り合いが取れるように輸液
手段７２を制御する。そして、浄化血漿輸液積算量をバ
ッファに転送し、輸液タイマをリセットする。輸液手段
７２によって送液された浄化血漿は、血漿分離器７から
流出した血球成分と第３送血管８で合流し、第１送血管
２、採血針２１を通って患者に返血される。Subsequently, it is determined whether the infusion timer = 0. The initial value of the infusion timer is, for example, 120 (s), and when the infusion timer ≠ 0, the infusion timer is counted down. When the infusion timer = 0, the weight detection means 1
From the weight of the purified plasma storage container 75 which is sequentially detected at 00, the purified plasma transfusion amount is obtained by the control unit 59,
The infusion means 72 is controlled so that the infusion rate and the plasma sampling rate are balanced. Then, the purified plasma infusion volume is transferred to the buffer, and the infusion timer is reset. The purified plasma that has been delivered by the infusion means 72 merges with the blood cell component that has flowed out of the plasma separator 7 in the third blood supply vessel 8, and is returned to the patient through the first blood supply vessel 2 and the blood collection needle 21.
【００２８】この血漿交換作業は、血漿採取量が血漿採
取設定量に達しない状態にて、採血容器５の重量（ＮＷ
N）より採血前の採血容器５の重量（ＮＷ0）を引いた重
量が、設定重量（Ｗth）以下（ＮＷN−ＮＷ0≦Ｗth）と
なるまで行われ、血漿採取重量と採血量から次回採血量
を演算して、下記の通り次回採血量を算出する。In this plasma exchange operation, the weight (NW) of the blood collection container 5 is measured when the amount of collected plasma does not reach the set amount of collected plasma.
It is performed until the weight obtained by subtracting the weight (NW 0 ) of the blood collection container 5 before blood collection from N ) becomes equal to or less than the set weight (W th ) (NW N −NW 0 ≦ W th ). Then, the next blood collection amount is calculated, and the next blood collection amount is calculated as follows.
【００２９】 血漿採取効率（η）＝今回血漿採取量／採血設定量 （１） 残り血漿交換量＝血漿交換設定量−浄化血漿輸液積算量 （２） 次回予想血漿採取量＝採血設定量×η （３） 残り血漿交換量≧次回予想血漿採取量の場合 次回採血量＝採血設定量 （４） 残り血漿交換量＜次回予想血漿採取量の場合 次回採血量＝残り血漿交換量／η＋α （５） （ただし、αは患者の血液ヘマトクリット値の上昇およ
び血漿分離器７の性能低下による血漿採取効率の低下を
見込んで、設定される量であり、通常は１０〜３０ｇ程
度の値である。） そして、浄化血漿輸液積算量が、血漿交換設定量に達す
ると、回路開閉手段１３、１４、１５は閉塞状態、バル
ブ５１、５２も大気開放状態となり、真空ポンプ４３の
作動も停止し、血漿交換モードは終了する。そして、患
者より穿刺針２１を抜去し、血漿交換を終了する。浄化
血漿輸液積算量が、血漿交換設定量に達しないうちは、
次回採血量の演算を行い図３のフローチャート［２］に
移行し、血漿交換設定量に達するまでこの作業を行う。
血漿採取容器１０に採取した血漿は次回の治療のときま
でに浄化を行い、次回の治療の際に浄化血漿として用い
る。Plasma collection efficiency (η) = Current plasma collection amount / Blood collection set amount (1) Remaining plasma exchange amount = Plasma exchange set amount-Purified plasma infusion integrated amount (2) Next expected plasma collection amount = Blood collection set amount × η (3) When the remaining plasma exchange amount ≧ next expected plasma collection amount Next blood collection amount = Set blood collection amount (4) When remaining plasma exchange amount <Next expected plasma collection amount Next blood collection amount = Remaining plasma exchange amount / η + α (5) (However, α is a set amount in anticipation of a decrease in plasma collection efficiency due to an increase in the blood hematocrit value of the patient and a decrease in the performance of the plasma separator 7, and is usually a value of about 10 to 30 g.) When the purified plasma infusion integrated amount reaches the plasma exchange set amount, the circuit opening / closing means 13, 14, 15 are closed, the valves 51, 52 are also open to the atmosphere, the operation of the vacuum pump 43 is stopped, and the plasma exchange mode is set. Ends . Then, the puncture needle 21 is removed from the patient, and the plasma exchange is completed. As long as the total volume of purified plasma infusion does not reach the plasma exchange set volume,
The next time the blood collection amount is calculated, the process proceeds to the flowchart [2] of FIG. 3, and this work is performed until the plasma exchange set amount is reached.
The plasma collected in the plasma collection container 10 is purified by the time of the next treatment, and is used as the purified plasma in the next treatment.
【００３０】[0030]
【実施例２】次に、実施例２の血漿交換回路を図３に示
す。[Embodiment 2] Next, the plasma exchange circuit of Embodiment 2 is shown in FIG.
【００３１】実施例１では、採血した全血を採血容器５
に貯留し、返血過程で血漿分離を行ったが、本実施例で
は採血過程で血漿分離を行うようにしている。この場
合、採血針２１が患者に穿刺された後、回路開閉手段１
２、１３、１４、１５が開放状態、回路開閉手段１６が
閉塞状態になる。そして、真空ポンプ４３のＯＮ／ＯＦ
Ｆ動作によって、採血容器収納部４１内の圧力が減圧状
態となり、採血が開始される。また、真空ポンプ４３の
動作に並行して抗凝固剤送液手段４７が作動し、抗凝固
剤が抗凝固剤輸送管４８、送血管２を通って送血管８に
送液され、採取した全血と合流する。抗凝固剤が添加さ
れた全血は、血漿分離器７に流入し、血漿成分と血球成
分に分離され、血漿成分は血漿輸送管９を通って血漿採
取容器１０に、血球成分は送血管６を通って採血容器５
に採取される。そして、採血過程では一定の周期で血漿
採取容器１０の重量が重量検知手段９９によって検知さ
れている。In the first embodiment, the collected whole blood is used as the blood collection container 5
The blood was collected and stored in the blood, and the plasma was separated during the blood returning process. In the present embodiment, however, the plasma is separated during the blood collecting process. In this case, after the blood collection needle 21 is punctured by the patient, the circuit opening / closing means 1
2, 13, 14, and 15 are open, and the circuit opening / closing means 16 is closed. And ON / OF of the vacuum pump 43
By the F operation, the pressure inside the blood collection container storage unit 41 is reduced, and blood collection is started. In addition, the anticoagulant solution sending means 47 is operated in parallel with the operation of the vacuum pump 43, and the anticoagulant is sent to the blood sending vessel 8 through the anticoagulant carrying tube 48 and the blood sending vessel 2, and all collected. Join the blood. The whole blood to which the anticoagulant is added flows into the plasma separator 7 and is separated into a plasma component and a blood cell component. The plasma component passes through the plasma transport tube 9 to the plasma collection container 10 and the blood cell component to the blood supply tube 6. Blood collection container 5 through
To be collected. Then, in the blood collection process, the weight of the plasma collection container 10 is detected by the weight detection means 99 at regular intervals.
【００３２】採血が終了すると、真空ポンプ４３、抗凝
固剤送液手段４７が停止し、回路開閉手段１３が閉塞常
態、回路開閉手段１６が開放状態となる。そして、真空
ポンプ４３の動作によって採血容器収納部４１内の圧力
が加圧状態となり、採血容器５に採取された血球成分
は、送血管２を通って送血管８に送られる。また、真空
ポンプ４３の動作に並行して輸液手段７２が作動し、浄
化血漿収納容器７５内の浄化血漿は浄化血漿輸送管７８
を通って送血管８に送液される。この時、浄化血漿収納
容器７５の重量は一定の周期で重量検知手段１００によ
って検知され、重量検知手段９９によって検知された血
漿採取量に応じた量の浄化血漿が送液される。浄化血漿
と血球成分は送血管８で合流し、採血針２１から患者に
返還される。When the blood collection is completed, the vacuum pump 43 and the anticoagulant liquid feeding means 47 are stopped, the circuit opening / closing means 13 is in the normal closed state, and the circuit opening / closing means 16 is in the open state. Then, the operation of the vacuum pump 43 causes the pressure inside the blood collection container storage portion 41 to become a pressurized state, and the blood cell component collected in the blood collection container 5 is sent to the blood supply vessel 8 through the blood supply vessel 2. Further, the infusion means 72 is operated in parallel with the operation of the vacuum pump 43, and the purified plasma in the purified plasma storage container 75 is purified plasma transport pipe 78.
And is delivered to the blood supply vessel 8. At this time, the weight of the purified plasma storage container 75 is detected by the weight detecting means 100 at a constant cycle, and the amount of purified plasma corresponding to the amount of collected plasma detected by the weight detecting means 99 is sent. The purified plasma and blood cell components merge in the blood supply tube 8 and are returned to the patient from the blood collection needle 21.
【００３３】[0033]
【実施例３】さらに、実施例３の血漿交換回路を図４に
示す。[Embodiment 3] Furthermore, the plasma exchange circuit of Embodiment 3 is shown in FIG.
【００３４】本実施例では、抗凝固剤収納容器４５と送
血管８を送液手段４７を介して輸送管４８によって連通
させ、血漿分離器７と採血容器５を送血管６によって連
通させることで回路を簡略化できる。さらに本実施例で
は、採血過程と返血過程の両方で血漿分離を行うことに
よって血漿交換効率を高めている。この場合、採血針２
１が患者に穿刺された後、回路開閉手段１４、１５が開
放状態になる。そして、真空ポンプ４３のＯＮ／ＯＦＦ
動作によって、採血容器収納部４１内の圧力が減圧状態
となり、採血が開始される。また、真空ポンプ４３の動
作に並行して抗凝固剤送液手段４７が作動し、抗凝固剤
が抗凝固剤輸送管４８を通って送血管８に送液され、採
取した全血と合流する。抗凝固剤が添加された全血は、
血漿分離器７に流入し、血漿成分と血球成分に分離さ
れ、血漿成分は血漿輸送管９を通って血漿採取容器１０
に、血球成分は送血管６を通って採血容器５に採取され
る。In this embodiment, the anticoagulant container 45 and the blood sending vessel 8 are connected by the transport tube 48 via the liquid sending means 47, and the plasma separator 7 and the blood collecting container 5 are connected by the blood sending vessel 6. The circuit can be simplified. Furthermore, in this example, plasma exchange efficiency is increased by performing plasma separation in both the blood collection process and the blood return process. In this case, blood collection needle 2
After 1 is punctured by the patient, the circuit opening / closing means 14, 15 are opened. Then, the vacuum pump 43 is turned on / off.
By the operation, the pressure inside the blood collection container storage unit 41 is reduced, and blood collection is started. Further, in parallel with the operation of the vacuum pump 43, the anticoagulant liquid feeding means 47 is activated, and the anticoagulant is fed to the blood feeding vessel 8 through the anticoagulant transportation pipe 48 and joins with the collected whole blood. . Whole blood with anticoagulant added,
It flows into the plasma separator 7 and is separated into a plasma component and a blood cell component, and the plasma component passes through the plasma transport pipe 9 and the plasma collection container 10
Then, the blood cell component is collected in the blood collecting container 5 through the blood supply vessel 6.
【００３５】採血が終了すると、真空ポンプ４３、抗凝
固剤送液手段４７が停止する。そして、再び真空ポンプ
４３の動作によって採血容器収納部４１内の圧力が加圧
状態となり、採血容器５に採取された血球成分は送血管
６を通って血漿分離器７に流入し、血球成分はさらに血
漿成分と血球成分に分離され、血漿成分は血漿輸送管９
を通って血漿採取容器１０に、血球成分は送血管８に送
られる。また、真空ポンプ４３の動作に並行して輸液手
段７２が作動し、浄化血漿収納容器７５内の浄化血漿は
浄化血漿輸送管７８を通って送血管８に送液される。こ
の時、血漿採取容器１０の重量は重量検知手段９９によ
って、浄化血漿収納容器７５の重量は重量検知手段１０
０によってそれぞれ一定の周期で検知され、血漿採取量
に応じた量の浄化血漿が送液される。浄化血漿と血球成
分は送血管８で合流し、採血針２１から患者に返還され
る。When the blood collection is completed, the vacuum pump 43 and the anticoagulant liquid feeding means 47 are stopped. Then, the pressure in the blood collection container storage portion 41 is brought into a pressurized state again by the operation of the vacuum pump 43, and the blood cell component collected in the blood collection container 5 flows into the plasma separator 7 through the blood supply vessel 6, and the blood cell component is Further, it is separated into a plasma component and a blood cell component.
The blood cell component is sent to the blood plasma collection container 10 and the blood cell component to the blood supply vessel 8. Further, the infusion means 72 is operated in parallel with the operation of the vacuum pump 43, and the purified plasma in the purified plasma storage container 75 is delivered to the blood supply vessel 8 through the purified plasma transport tube 78. At this time, the weight of the plasma collection container 10 is determined by the weight detection means 99, and the weight of the purified plasma storage container 75 is determined by the weight detection means 10.
0 is detected in a fixed cycle, and purified plasma is delivered in an amount corresponding to the amount of collected plasma. The purified plasma and blood cell components merge in the blood supply tube 8 and are returned to the patient from the blood collection needle 21.
【００３６】[0036]
【発明の効果】本発明の血漿交換装置は、患者から採血
針を介して全血を採取する採血回路と、採取される全血
に抗凝固剤を添加する抗凝固剤添加回路と、抗凝固され
た全血を血漿成分と血球成分に分離する血漿分離器と、
血漿成分を採取する血漿採取容器と、血球成分に浄化血
漿を添加する浄化血漿添加回路と、血球成分および浄化
血漿を患者に採血針から返還する返血回路と、血漿採取
量を検知する手段と、送液された浄化血漿量を検知する
手段とを少なくとも有し、血漿採取量に応じた量の浄化
血漿を血球成分に加え患者に返還するように制御する血
漿交換量制御機構を有し、血漿の浄化時における異常が
患者に影響することを防止し、また、血漿浄化に必要な
時間を短縮し、人体にかかる負担を少なくすることがで
きる。The plasmapheresis device of the present invention comprises a blood collection circuit for collecting whole blood from a patient via a blood collection needle, an anticoagulant addition circuit for adding an anticoagulant to the collected whole blood, and an anticoagulant. A plasma separator for separating the separated whole blood into a plasma component and a blood cell component,
A plasma collection container for collecting plasma components, a purified plasma addition circuit for adding purified plasma to blood cell components, a blood return circuit for returning blood cell components and purified plasma from a blood collection needle to a patient, and means for detecting the amount of plasma collected A plasma exchange amount control mechanism that has at least a means for detecting the amount of purified plasma that has been sent, and that controls to add an amount of purified plasma according to the plasma collection amount to the blood cell component and return it to the patient. It is possible to prevent abnormalities during plasma purification from affecting the patient, shorten the time required for plasma purification, and reduce the burden on the human body.
【図１】図１は、本発明の血漿交換装置の実施例と血漿
交換回路との接続状態を説明するための回路接続図であ
る。FIG. 1 is a circuit connection diagram for explaining a connection state between an embodiment of a plasma exchange apparatus of the present invention and a plasma exchange circuit.
【図２】図２は、本発明の血漿交換装置の実施例の概略
図である。FIG. 2 is a schematic view of an embodiment of the plasmapheresis device of the present invention.
【図３】図３は、本発明の血漿交換装置の実施例２の概
略図である。FIG. 3 is a schematic view of a second embodiment of the plasmapheresis device of the present invention.
【図４】図４は、本発明の血漿交換装置の実施例３の概
略図である。FIG. 4 is a schematic diagram of Example 3 of the plasmapheresis apparatus of the present invention.
【図５】図５は、本発明の実施例の血漿交換装置の作用
を説明するためのフローチャートである。FIG. 5 is a flow chart for explaining the operation of the blood plasma exchange device according to the embodiment of the present invention.
【図６】図６は、本発明の実施例の血漿交換装置の作用
を説明するためのフローチャートである。FIG. 6 is a flow chart for explaining the operation of the blood plasma exchange device according to the embodiment of the present invention.
【図７】図７は、本発明の実施例の血漿交換装置の作用
を説明するためのフローチャートである。FIG. 7 is a flow chart for explaining the operation of the blood plasma exchange device according to the embodiment of the present invention.
１ 血漿交換装置 ５ 採血容器 ７ 血漿分離器 ９ 血漿輸送管 １０ 血漿採取容器 ４１ 採血容器収納部 ４５ 抗凝固剤収納容器 ５７ 採血容器の重量検知部 ５９ 制御部 ７２ 輸液手段 ７５ 浄化血漿収納容器 ７８ 浄化血漿輸送管 ９９ 血漿採取容器の重量検知手段 １００ 浄化血漿収納容器の重量検知手段 1 Plasma Exchange Device 5 Blood Collection Container 7 Plasma Separator 9 Plasma Transport Tube 10 Plasma Collection Container 41 Blood Collection Container Storage 45 Anticoagulant Storage Container 57 Blood Collection Container Weight Detector 59 Control Part 72 Infusion Means 75 Purification Plasma Storage Container 78 Purification Plasma transport tube 99 Plasma detection container weight detection means 100 Purified plasma storage container weight detection means
Claims (1)
血回路と、採取される全血に抗凝固剤を添加する抗凝固
剤添加回路と、抗凝固された全血を血漿成分と血球成分
に分離する血漿分離器と、血漿成分を採取する血漿採取
容器と、血球成分に浄化血漿を添加する浄化血漿添加回
路と、血球成分および浄化血漿を患者に前記採血針から
返還する返血回路と、血漿採取量を検知する手段と、送
液された浄化血漿量を検知する手段とを少なくとも有
し、血漿採取量に応じた量の浄化血漿を血球成分に加え
患者に返還するように制御する血漿交換量制御手段を有
していることを特徴とする単針式血漿交換装置。1. A blood collection circuit for collecting whole blood from a patient via a blood collection needle, an anticoagulant addition circuit for adding an anticoagulant to the collected whole blood, and anticoagulated whole blood as a plasma component. Plasma separator for separating blood cell components, plasma collection container for collecting plasma components, purified plasma addition circuit for adding purified plasma to blood cell components, and blood return for returning blood cell components and purified plasma to the patient from the blood collection needle A circuit, a means for detecting the amount of collected plasma, and a means for detecting the amount of purified plasma that has been sent are included, and an amount of purified plasma according to the amount of collected plasma is added to blood cell components and returned to the patient. A single-needle plasma exchange apparatus having a plasma exchange amount control means for controlling.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5042404A JPH06254152A (en) | 1993-03-03 | 1993-03-03 | Blood plasma changing device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5042404A JPH06254152A (en) | 1993-03-03 | 1993-03-03 | Blood plasma changing device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH06254152A true JPH06254152A (en) | 1994-09-13 |
Family
ID=12635137
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP5042404A Pending JPH06254152A (en) | 1993-03-03 | 1993-03-03 | Blood plasma changing device |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH06254152A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002291873A (en) * | 2001-03-29 | 2002-10-08 | Terumo Corp | Blood component collector |
| JP2013188475A (en) * | 2012-03-12 | 2013-09-26 | Grifols Sa | Method and device for treating blood cholesterol disorder |
-
1993
- 1993-03-03 JP JP5042404A patent/JPH06254152A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002291873A (en) * | 2001-03-29 | 2002-10-08 | Terumo Corp | Blood component collector |
| JP2013188475A (en) * | 2012-03-12 | 2013-09-26 | Grifols Sa | Method and device for treating blood cholesterol disorder |
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