CN103492041A - Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly - Google Patents

Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly Download PDF

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CN103492041A
CN103492041A CN201280020712.9A CN201280020712A CN103492041A CN 103492041 A CN103492041 A CN 103492041A CN 201280020712 A CN201280020712 A CN 201280020712A CN 103492041 A CN103492041 A CN 103492041A
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oxygen
rbc
gas
consumer
portable system
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CN103492041B (en
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保罗·韦尔努奇
吉田达郎
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Ximanexter Co Ltd
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New Health Sciences Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0209—Multiple bag systems for separating or storing blood components
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0209—Multiple bag systems for separating or storing blood components
    • A61M1/0218—Multiple bag systems for separating or storing blood components with filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0429—Red blood cells; Erythrocytes

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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Abstract

A portable assembly for processing red blood cells RBCs including a disposable blood collection set including a blood bag, an anaerobic storage bag and an oxygen and/or oxygen and carbon dioxide depletion device disposed between the blood collection bag and anaerobic storage bag. The portable assembly further provides for a gas circulation device in fluid communication with the oxygen or oxygen and carbon dioxide depletion device, The gas circulation device includes a pressure source that is able circulate flushing gas through the depletion device as RBCs pass from the blood collection bag, through the depletion device and into the anaerobic storage bag.

Description

Remove the method and system of oxygen and carbon dioxide for use inert carrier gas and manifold component in red blood cell blood treatment process
Background of invention
1. technical field
Present disclosure relates to portable blood handle manifold assembly.More specifically, present disclosure relates to when storing for blood and/or prepare to recipient's blood transfusion for removing leucocyte and consuming the oxygen of blood and/or the portable blood handle manifold assembly of carbon dioxide.
2. background technology
The supply of liquid blood is subject to the restriction that traditional blood stores the stocking system used in practice at present.Use current system, stored blood refrigerates about 42 days as the haemocyte preparation of packing in temperature above freezing (1 ℃ to 6 ℃) and lost efficacy afterwards.Red blood cell (RBC) may aggegation from whole blood, with liquid blood constitutent (blood plasma), separates.The blood lost efficacy can not be used and need to abandon.
The periodicity shortage of blood, can occur in unstable, emergency and other factors due to donations.The logistics impact of blood supply and distribution military (especially during the fight), remote hospital or medical facilities make blood treatment or transfuse blood very difficult.Therefore, at far zone, needing can be promptly for the preparation of the RBC that stores or transfuse blood.
The storage of frozen blood is known in the art, but such frozen blood has limitation.For many years, for the blood of specific high request and infrequent types, blood bank and army have been used frozen blood.Yet frozen blood is difficult to process.Frozen blood must be thawed, and this makes frozen blood be not suitable for for emergency.Once blood is thawed, it must use in 24 hours.The 6th of Serebrennikov, 413, No. 713 United States Patent (USP)s relate to the method for storing blood at the temperature below 0 ℃.
The 4th, 880, No. 786 United States Patent (USP)s of the people such as the 4th, 769, No. 318 United States Patent (USP)s of the people such as Hamasaki and Sasakawa relate to the interpolation solution for preservation and the activation of blood.The people's such as the 5th, 624, No. 794 United States Patent (USP)s of the people such as Bitensky, Bitensky the 6th, 162, No. 396 United States Patent (USP)s and the 5th, 476, No. 764 United States Patent (USP)s relate under anaerobic conditions erythrocytic storage.The 5th, 789, No. 151 United States Patent (USP)s of the people such as Bitensky relate to blood and store interpolation solution.
The interpolation solution of preserving and activating for blood known in the state of the art.For example, before, after refrigeration, (4 ℃) face blood transfusion or freezing (using glycerine under-80 ℃) before in extend storing and adding Rejuvesol (can purchased from enCyte Corp., Braintree, MA) to blood.The 6th, 447, No. 987 United States Patent (USP)s of the people such as Hess relate to the additive solution of HRBC's refrigeration.
According to prior art, the portable and cost-effective apparatus and method of the preparation of the RBC of removal leucocyte and oxygen and/or carbon dioxide while needing to be used for preparing before blood transfusion or for the anaerobic storage.
Summary of the invention
Therefore, provide can be before blood transfusion or remove oxygen and/or carbon dioxide and/or leukocytic system for the further storage of oxygen-free environment from RBC for present disclosure.
Present disclosure also provides for learning before blood transfusion or for the system and method for the preparation of the RBC of the further storage of oxygen-free environment.
Another purpose of present disclosure is to provide independently portable system, it has oxygen or oxygen/carbon dioxide-depleted (oxygen/carbon dioxide depletion, OCDD) device, described device is removed oxygen or oxygen and/or carbon dioxide from pass through the RBC of this device.OCDD device and gas exchange system co-operate, described gas exchange system pumps into gas in the OCDD device, by the OCDD device, at first RBC removes oxygen or oxygen/carbon dioxide through peroxide or oxygen/carbon dioxide-depleted (OCDD) device with the RBC from such.RBC is oxygen consumed or oxygen/carbon dioxide and be deposited in the blood reservoir bag storage for extending or the storage before blood transfusion thus.
The another purpose of present disclosure is to provide the independently portable system that gas is pumped into to this device, by this device, RBC process leukocyte depletion filtration device and oxygen and/or carbon dioxide-depleted (OCDD) device to remove respectively leucocyte and oxygen or oxygen/carbon dioxide from this RBC.RBC does not have leucocyte and oxygen consumed or oxygen/carbon dioxide thus, and is deposited in the blood reservoir bag for the storage of prolongation or the storage before blood transfusion.
A purpose again of present disclosure is to provide independently portable system, this system makes the air of oxygen depletion and/or air or the noble gas mixtures of carbon dioxide adjusting cycle through the OCDD device to remove such gas, the preparation that stores or transfuse blood as anaerobic the RBC from the filter of flowing through.Such system comprises lambda sensor, carbon dioxide sensor and/or partial pressure sensor at the inlet manifold that receives the air be rich in oxygen and/or carbon dioxide or inert gas from the OCDD device with exporting between manifold.The air that Sensor monitoring and adjusting receive from the outlet manifold or the level of the oxygen noble gas mixtures and/or carbon dioxide, and monitor by blowback the oxygen and carbon dioxide dividing potential drop to the gas after filtration of OCDD device.
A purpose again of present disclosure is to provide independently portable system, this system reduces leucocyte and makes oxygen and/or air or noble gas mixtures that carbon dioxide is regulated cycle through the OCDD device to remove such gas from RBC, as anaerobic, stores or the preparation of blood transfusion.Such system comprises lambda sensor, carbon dioxide sensor and/or partial pressure sensor between inlet manifold and outlet manifold, described inlet manifold receives air or the noble gas mixtures that is rich in oxygen and/or carbon dioxide from the OCDD device, described outlet manifold makes the air of oxygen and/or carbon dioxide-depleted or noble gas mixtures be back to the OCDD device.Oxygen and/or carbon dioxide level in the gas received in Sensor monitoring and adjusting outlet manifold, and monitor by blowback the oxygen and carbon dioxide dividing potential drop to the gas of OCDD device.
The portable components for the treatment of red blood cell RBC that comprises the disposable blood liquor collecting device, described assembly comprise blood bag, anaerobic reservoir bag and be arranged on blood collection bag and the anaerobic reservoir bag between oxygen and/or oxygen and carbon dioxide-depleted device.This portable components also provides the gas-recycling plant be communicated with oxygen or oxygen and carbon dioxide-depleted device fluid, this gas-recycling plant comprises pressure source, when RBC enters the anaerobic reservoir bag from blood collection bag through consumer, this pressure source can make flushing gas cycle through consumer.
For the treatment of the portable components of red blood cell (RBC), comprise oxygen or oxygen and carbon dioxide-depleted (OCDD) device.This OCDD device comprise the filter cylinder with entrance and exit and be arranged on entrance and the outlet between for transporting RBC by a plurality of doughnuts of OCDD device.A plurality of doughnuts by continuous space around.This portable components comprises the gas exchange device be communicated with OCDD device fluid.This gas exchange device comprises the pressure source that can make flushing gas cycle through continuous space and remove oxygen and/or carbon dioxide from the RBC through the OCDD device.
These and other purpose of the present invention and advantage with and counterpart by described herein and method and composition of the present invention that present in the appended claims, realize.
The accompanying drawing explanation
Fig. 1 a shows the Portable blood liquid treating system according to present disclosure;
Fig. 1 b shows the alternative embodiment of present disclosure, and wherein, applied load sensor (load cell) is processed red blood cell;
Fig. 1 c shows the OCDD device that is connected directly to treatment system of the embodiment of Fig. 1 b;
Fig. 1 d shows the gathering system that comprises flow regulator according to the embodiment of Fig. 1 b;
Fig. 1 e shows the gathering system that comprises the leukocyte depletion filtration device with OCDD device;
Fig. 2 a to Fig. 2 c shows the leukocyte depletion filtration device in the OCDD device that is included according to the embodiment of Fig. 1 e;
Fig. 2 d shows the OCDD device of the embodiment of Fig. 1 a;
Fig. 3 shows the OCDD device according to another embodiment of present disclosure, and it has OCDD device, leukocyte depletion filtration device and plasma separating unit in overall structure.
The specific embodiment
With reference to Fig. 1, show independently blood processing system and use Reference numeral 10 for its interpolation note.System 10 comprises shell 15 and supports blood to collect and consumption systems 100 (hereinafter referred to as " gathering system 100 ").Gathering system 100 comprises blood bag 200, leukocyte depletion filtration device 300, oxygen and/or carbon dioxide-depleted (OCDD) and installs 400 and anaerobic reservoir bag 600.Device 400 can exhaust oxygen or exhaust as an alternative oxygen and carbon dioxide from the gas from RBC.It is inner so that may can move easily and transport the blood preparation process away from the position of standard hospital device or clinical setting that gathering system 100 is suspended at system 10.The direction of system 100 allows the RBC in blood bag 200 to flow to anaerobic reservoir bag 600 under the effect of gravity.Although show single gathering system 100, yet the support 12 of shell 15 can support as many as and be equal to or greater than 10 such treatment systems.Shell 15 air inclusion EGRs, described gas-recycling plant comprises such as pressure source, the valve/pressure regulator 40 of pump 30 or aspirator (vacuum) or pressurizing vessel and makes gas to circulate and through the miscellaneous part that will further discuss of OCDD device 400.Entrance 410 and outlet 415 (Fig. 2 d) are connected to respectively pipe 427 and pipe 426.
Gathering system 100 comprises the blood bag 200 that holds the RBC collected from whole blood.Usually, use traditional method to collect whole blood from the donor, and use centrifugal process to process whole blood with separated plasma and RBC.Blood bag 200 is blood collection bag of standard.RBC is collected in the blood bag 200 that may comprise additive.Interpolation solution such as OFAS3 comprises adenine, glucose, sweet mellow wine, NaH 2pO 4and optionally comprise NaCl and/or NH 4cl.Add solution O FAS3 and preferably comprise the composition with following scope: the NaCl of the adenine of about 0.5mmol/L to 4.0mmol/L, the glucose of about 50mmol/L to 150mmol/L, the sweet mellow wine of about 20mmol/L to 70mmol/L, about 0mmol/L to 100mmol/L, the NaH of about 2mmol/L to 20mmol/L 2pO 4and the NH of about 0mmol/L to 30mmol/L 4cl.Preferably, OFAS3 has approximately 5.5 to 7.5 pH value and the adenine that comprises about 2mmol/L, the glucose of about 110mmol/L, the NaCl of about 55mmol/L and the NaH of about 12mmol/L through adjusting 2pO 4, and about 6.5 the pH value through adjusting.Can also in this system, use additive or approval such as SAGM, PAGG-SM, AS-1, AS-3, AS-5, SOLX, MAPS, PAGG-GM to be used for any additive that blood stores.
The RBC be contained in blood bag 200 flows to leukocyte depletion filtration device 300 and the OCDD device 400 of flowing through under the effect of gravity.Removing leucocyte (leukoreduction) is the leukocytic process of removing from whole blood or RBC.Leucocyte in blood product can cause immunosuppressive action and can make patient be exposed to the risk of the increase of virus and fever, and RBC is had to ill-effect.Remove reduction of leukocyte RBC store damage, reduced primary isoimmunization and reduced the sum of transfusion reaction.
After the leukocytic process of removing RBC preferably occur in and from blood plasma, isolates RBC, and before or after can occurring in and from RBC, removing oxygen and carbon dioxide.In both cases, before the removal leucocyte all should occur in and be stored in anaerobic reservoir bag 600 by RBC.
With reference to Fig. 2 a, Fig. 2 b and Fig. 2 c, leukocyte depletion filtration device 300 is included in OCDD device 500.OCDD device 500 comprises filter cylinder 505, entrance 510, leukocyte depletion filtration device 520, a plurality of doughnut 530 and holds the fibrous framework 540 of a plurality of doughnuts 530.OCDD device 500 also comprises the outlet of passing through 515 for RBC.Leukocyte depletion filtration device 520 is preferably caught so leukocytic fiber filter material or the filtering material of similar felt at leucocyte through before a plurality of doughnuts 530.Fibrous framework 540 supports a plurality of doughnuts 530 of vertical structure and can be made by the material such as polyurethane or similar material.Whole blood or Red Blood Cells Concentrate (pRBC) filter 520 of flowing through in removing the leucocyte processing procedure.OCDD device 500 is communicated with the gas that carrys out self-pumping 30 via entrance 524 and outlet 528.
OCDD filter cylinder 500 comprises approximately 5000 fibers that pass through for RBC.Can use more multifilament or still less fiber with produce enough surface areas for the gas exchange so that oxygen concentration and/or gas concentration lwevel are reduced to aspiration level.A plurality of doughnuts 530 are in order to remove oxygen or oxygen and carbon dioxide from RBC, and will be discussed further below.The gas compartment 550 of and filter cylinder 505 inside outside at doughnut is around a plurality of doughnuts 530 and be full of carrier gas.When carrier gas cycles through OCDD device 500, the gas permeation material of a plurality of doughnuts 530 or porous material make oxygen and carbon dioxide to be passed to such carrier gas from RBC.By the flushing gas of suitable composition is provided, OCDD device 500 consumes O 2and CO 2, or O 2, or CO only 2, or there is specified level CO 2o 2.The gas that is applicable to be consumed in the OCDD device is any inert gas that can not damage RBC or receptor, for example Ar, He, N 2, Ar/CO 2, He/CO 2or N 2/ CO 2.
RBC flows into OCDD device 500 to be consumed oxygen or oxygen and carbon dioxide.OCDD device 500 is reduced to RBC hemoglobin saturation with oxygen level lower than 3% under 37 ℃, and partial pressure of carbon dioxide is reduced to lower than 50 holders.OCDD device 500 is to remove oxygen and carbon dioxide with the shelf life that extends such RBC the combination oxygen and carbon dioxide filter that promotes best blood transfusion from RBC.The shell 115 of OCDD device 500 and Fig. 1 e and support 12 are jointly used and comprise the parts identical with the embodiment of Fig. 1 a.
As an alternative, as shown in Figure 2 d, OCDD device 400 does not comprise the leucocyte ability and only can be from through oxygen consumed or oxygen and carbon dioxide its RBC removed.Fig. 2 d shows OCDD device 400, and it has the entrance entered 410 for RBC, for the outlet of passing through 415 and a plurality of fiber 430 of RBC, such RBC by described a plurality of fibers 430 to remove oxygen and/or carbon dioxide.OCDD device 400 also comprises the ingate 424 of flushing gas and the outlet opening 428 left for flushing gas and, around a plurality of spaces 450 of a plurality of fibers 430 of filter cylinder 405 inside, the gas exchange from RBC to flushing gas occurs in described a plurality of spaces 450.Guaranteed to be stored in the acceptable level of oxygen and carbon dioxide dividing potential drop in the Optimum storage for RBC of the RBC in bag 600 by the gas circulation of OCDD device 400 via ingate 424, outlet opening 428 and a plurality of space 450.
Referring again to Fig. 1 a, shell 15 comprises inlet manifold 20, pump 30, outlet manifold 60 and inlet valve/pressure regulator 40.OCDD filter cylinder 400 by pipe 27 and 13 or directly connector 128 and 124 (Fig. 1 c) be connected to respectively inlet manifold 20 and outlet manifold 60.Be provided with the first oxygen/carbon dioxide sensor 50 and the second oxygen/carbon dioxide sensor 90 between inlet manifold 20 and outlet manifold 60.System 10 can be connected to AC socket (AC outlet) or other power supplys for operating pumps 30.As an alternative, system 10 can be connected to the remote operated battery for system 10.
Shell 15 comprises disposable or reusable adsorbent filter cylinder 75, and described adsorbent filter cylinder 75 is arranged between inlet manifold 20 and outlet manifold 60 to purify air or the noble gas mixtures through OCDD device 400.Adsorbent filter cylinder 75 is that be preferably can be physically or iron-based or the large filter cylinder other inorganic compounds and/or organic compound of adsorb oxygen or oxygen/carbon dioxide chemically.Adsorbent filter cylinder 75 comprises oxygen and/or carbon dioxide absorber 76.As the alternative of large adsorbent bag (large sorbent pack) or organic compound and inorganic compound, membrane filter (as the membrane filter found in Nitrogen Generator System) that can be by use being the gas separate design is removed oxygen and carbon dioxide from the air that is rich in oxygen and carbon dioxide or noble gas mixtures.Outside deoxygenation or oxygen/carbon dioxide absorber 76, adsorbent filter cylinder 75 also comprises the volatile matter that active carbon filter 78 is produced by oxygen or oxygen/carbon dioxide absorber with absorption.Active carbon filter 78 also comprises the HEPA filter to remove any particulate.
System 10 also comprises multiple except mattress filter sensors assembly 70,80 and 85.Except mattress filter sensors assembly 70 is arranged between pipe 23 and inlet manifold 20.Except mattress filter sensors assembly 80 is arranged between outlet manifold 60 and pipe 27.Filter 70 and filter 80 catch air-flow and the filtration of infringement RBC and/or any pathogen and/or the particulate of purification that can enter between each pipe and manifold.Filter in filter sensors assembly 70 and filter sensors assembly 80 is monitored the oxygen and carbon dioxide minute voltage levels of single OCDD device 400 (or 500).Except mattress filter 85 is arranged between the exterior section and inlet valve pressure regulator 40 of shell 15.Except mattress filter sensors assembly 85 is monitored the gas that enters pump 30.The filter capture system 10 of filter sensors assembly 85 and the pathogen between surrounding air or noble gas mixtures and particulate and can sensing oxygen, the level of carbon dioxide, temperature and pressure and humidity. Filter sensors assembly 70,80 and 85 also plays the effect of sensor and is communicated with controller 35.Controller 35 uses predetermined set point to programme to monitor and control the concentration of oxygen and carbon dioxide and the gross pressure of flow, temperature, humidity and admixture of gas.If level is inappropriate, such as the alarm signal notification operator of lamp or alarm clock, should change adsorbent filter cylinder, sterilizing filter or HEPA filter.
Shell 15 comprises movement and the placement of caster 25 with permission system 10.System 10 also comprises large adsorbent filter cylinder 75 or doughnut gas separation module.
As shown in Figure 1, in operation, RBC directly or via the leukocyte depletion filtration device flows into the OCDD filter cylinder from collecting bag 200.Make flushing gas cycle through OCDD filter cylinder 400 simultaneously.The gas through oxygen or oxygen/carbon dioxide adjustment that flows to OCDD filter cylinder 400 is carried by pipe 27, from oxygen enrichment or the oxygen enrichment/carbon dioxide of OCDD filter cylinder 400, by pipe 23, is carried.Pipe 23 is connected to inlet manifold 20, manages 27 and is connected to outlet manifold 60.Pipe 23 is by being connected to inlet manifold except mattress filter sensors assembly 70.Similarly, outlet manifold 60 is by being connected to pipe 27 except mattress filter 80.
The noble gas mixtures of oxygen-enriched air or oxygen enrichment via pipe 23 from OCDD device 400 out after, such air or noble gas mixtures are received at inlet manifold 20 places, and are pumped through sensor 50 via pump 30.Pump 30 moves to maintain the air-flow by system 10.The electric driving pump that pump 30 is preferably regulated pressure and flowed.Pump 30 is connected to valve 40, and valve 40 preferably receives check valve and the pressure regulator of the inert gas of surrounding air in environmental pressure or noble gas mixtures or the pressure in promoting.Sensor 50 and sensor 90 are measured the oxygen and carbon dioxide dividing potential drop, except the gas dividing potential drop, also measure temperature, flow velocity, total pressure and the humidity of whole portable components.Air or inert gas are cleaned and are back to OCDD 400 before the inflow of the RBC such anaerobic reservoir bag 600, to continue to consume RBC in filter cylinder 75.
Fig. 1 b to Fig. 1 d shows the alternative embodiment of shell 115.Shell 115 comprises less gas replacement part, as shell 15.That is to say, shell 115 also comprises inlet manifold 20, pump 30, outlet manifold 60 and the inlet valve/pressure regulator 40 that is included in shell 115 inside.Shell 115 also comprises the load sensor 6 that is connected to bag 200 and flow control valve 470.Load sensor 6 is measured the Unit Weight in bag 200 and the mass change in bag is conveyed to controller 35, and controller 35 communicates by letter to monitor the flow by the RBC of OCDD device 400 with flow control valve 470.Variation by the quality of RBC in monitoring bag 200, can be sufficiently removed oxygen or oxygen and carbon dioxide with the RBC that guarantees to stay in OCDD device 400 by control valve 470.Controller 35 and load sensor 6, flow control valve 470 and oxygen saturation sensor 475 telecommunications.The oxygen saturation levels that oxygen saturation sensor 475 is measured in RBC.Controller 35 receives the signal of indicating oxygen saturation levels and transfers transmitted signal to adjust flow control valve 470 to guarantee sufficient oxygen consumption level in RBC.Some bags 200 (Fig. 1 b) can be connected to shell 115, although and only show 1 flow control valve 470, some bags 200 all can similarly be equipped with flow control valve 470.Shell 115 has outer surface, and OCCD device 400 can be connected directly to this outer surface via coupling (coupling).As shown in Fig. 1 b to Fig. 1 d, by configuration OCDD device 400, make it via coupling 124 and coupling 128, be connected directly to shell 115, eliminated the demand for the pipe in the embodiment of Fig. 1 a.The configuration of shell 115 also can be used together with the device 500 that comprises removal leucocyte ability.
With reference to Fig. 3, multi-functional OCDD device 700 is combinations of combination leukocyte depletion filtration device 710, OCDD device 720 and plasma separator 730.Multi-functional OCDD device 700 has been eliminated the needs that the whole blood to being received from the contributor is separated, and this whole blood is used centrifuge to separate at present.By these three devices are combined into to single assembly, eliminated for the needs of this expensive and heavy device of centrifuge independently.This embodiment comprises removes leucocyte part 710, OCDD device 720 and plasma separator 730.Plasma flow is processed for further through port 740 to another collecting bag.Therefore, in this embodiment, can gather whole blood from the contributor, can remove leucocyte, can remove oxygen or oxygen and carbon dioxide, and can remove blood plasma and blood platelet so that RBC through this device.Then make RBC be deposited in collecting bag 600 for storing or transfusing blood to the receptor.Multi-functional OCDD 700 as the part of gathering system 100 and system 10 allow whole blood to the rapid conversion of the RBC stored to store immediately or to transfuse blood to the receptor.
Although present disclosure is described some embodiment in detail, However, it should be understood that the variation well known by persons skilled in the art and the modification that exist in present disclosure.Therefore, present disclosure is intended to be included in the scope of present disclosure substitute, the modifications and variations as present disclosure was proposed so all.

Claims (27)

1. for the treatment of the portable system of red blood cell (RBC), it comprises:
The disposable blood liquor collecting device, described disposable blood liquor collecting device comprise blood bag, anaerobic reservoir bag and be arranged on described blood collection bag and described anaerobic reservoir bag between oxygen and/or oxygen and carbon dioxide-depleted device; And
Gas-recycling plant, described gas-recycling plant is communicated with described oxygen/oxygen and carbon dioxide-depleted device fluid, and described gas-recycling plant can make flushing gas cycle through the pressure source of described consumer when being included in RBC from the described blood collection bag described consumer of process and entering described anaerobic reservoir bag.
2. portable system according to claim 1, wherein, described consumer comprises filter cylinder, extends to a plurality of doughnuts of outlet from the entrance of described filter cylinder in described filter cylinder, and around the continuous space for described flushing gas is passed through of described a plurality of doughnuts.
3. portable system according to claim 2, wherein, described a plurality of doughnut air inclusion penetration materials or porous material and be suitable for receiving and carrying red blood cell.
4. according to the described portable system of claim l, it also comprises the shell that holds described gas-recycling plant, wherein, described shell also comprise inlet manifold for receive flushing gas from described consumer, for the outlet manifold of flushing gas is provided to described consumer and be arranged on described pressure source with described outlet manifold between for the adsorbent from described flushing gas removal oxygen and/or oxygen and carbon dioxide.
5. portable system according to claim 4, its also comprise be arranged on the sensor between described pressure source and described adsorbent and be arranged on adsorbent and described outlet manifold between for detection of the second sensor of oxygen and/or carbon dioxide level in flushing gas described in described OCDD.
6. portable system according to claim 1, wherein, described consumer also comprises the leukocyte depletion filtration device.
7. portable system device according to claim 1, wherein, described consumer also comprises leukocyte depletion filtration device and plasma separator.
8. portable system according to claim 1, it also comprises the load sensor that is connected to described collecting bag, is arranged on the flow control valve between described consumer and described anaerobic reservoir bag, and controller.
9. portable system according to claim 8, wherein, described load sensor is measured the weight of RBC in described collecting bag, and described controller receives the signal of the described RBC weight of indication and passes on signal to adjust described flow control valve to described flow control valve, thereby restriction or promote flowing of RBC, control thus described RBC in described consumer with the contacting of flushing gas.
10. portable system according to claim 8, it also comprises the oxygen saturation sensor be arranged between described consumer and described flow control valve, wherein, described controller receive the signal of oxygen saturation levels in the described RBC of indication and to described flow control valve transmitted signal to adjust described flow control valve, thereby restriction or promote flowing of RBC, control thus described RBC in described consumer with the contacting of flushing gas.
11. portable system according to claim 1, wherein, described flushing gas comprises Ar, He, N 2, Ar/CO 2, He/CO 2or N 2/ CO 2perhaps inert gas and/or CO 2any combination.
12. portable system according to claim 1, it also comprises a plurality of disposable blood liquor collecting devices that are connected to described shell and are communicated with described gas-recycling plant fluid.
13. portable system according to claim 1, wherein, described pressure source is selected from pump, aspirator or pressurizing vessel.
14., for the treatment of the portable system of red blood cell (RBC), it comprises:
Oxygen or oxygen and carbon dioxide-depleted (OCDD) device, described oxygen or oxygen and carbon dioxide-depleted (OCDD) device comprises filter cylinder, described filter cylinder there is entrance and exit and be arranged on described entrance and described outlet between for transporting RBC by a plurality of doughnuts of described OCDD device, wherein, described a plurality of doughnut by continuous space around; And
Gas-recycling plant, described gas-recycling plant is communicated with described OCDD device fluid, wherein, described gas-recycling plant comprises the pressure source that can make flushing gas cycle through described continuous space and remove oxygen and/or carbon dioxide from the process RBC of described OCDD device.
15. portable system according to claim 14, it also comprises blood bag and anaerobic reservoir bag, and wherein, described blood bag is connected to described entrance, and described anaerobic reservoir bag is connected to described outlet.
16. portable system according to claim 14, it also comprises the shell with outer surface, and described shell holds described gas-recycling plant, and wherein, described consumer is the even described outer surface that is connected to described shell directly.
17. portable components according to claim 14, it also comprises the shell with outer surface, and described shell holds described gas exchange device and a plurality of consumer, and wherein, described a plurality of consumers are the even described outer surface that is connected to described shell directly.
18. portable system according to claim 14, it also comprises load sensor, flow control valve and controller, wherein, described load sensor is measured the weight of RBC in described blood bag, and described controller receives the signal of the weight of indicating described RBC and passes on signal to adjust described flow control valve to described flow control valve, thereby restriction or promote flowing of described RBC, reduce thus or increase described RBC in described consumer with the contacting of flushing gas.
19. portable system according to claim 18, it also comprises the oxygen saturation sensor be arranged between described consumer and described flow control valve, wherein, described controller receive the signal of oxygen saturation levels in the described RBC of indication and to described flow control valve transmitted signal to adjust described flow control valve, thereby restriction or promote flowing of described RBC, and increase or reduce described RBC in described consumer with the contacting of flushing gas.
20. portable system according to claim 17, wherein, described shell also hold inlet manifold for receive flushing gas from described consumer, for the outlet manifold of flushing gas is provided to described consumer and be arranged on described pressure source with described outlet manifold between for the adsorbent from described flushing gas removal oxygen or oxygen and carbon dioxide.
21. portable system according to claim 20, it also comprises the system sensor that is arranged in described adsorbent offside and receives and the flushing gas oxygen of filtration or the level of oxygen and carbon dioxide at described adsorbent with sensing.
22. portable system according to claim 14, wherein, described consumer also comprises the leukocyte depletion filtration device.
23. portable components device according to claim 14, wherein, described consumer also comprises leukocyte depletion filtration device and plasma separator.
24. portable system according to claim 20, its also comprise be arranged on the filter sensors assembly between described consumer and described inlet manifold and be arranged on described consumer and described outlet manifold between the filter sensors assembly, the gas parameter level for monitoring stream through the gas of described entrance and described outlet.
25. portable system according to claim 24, wherein, be arranged on described filter sensors assembly between described consumer and described inlet manifold and described consumer, be arranged on flow through partial pressure of oxygen, partial pressure of carbon dioxide, temperature, pressure, humidity and the gas flow rate of gas of described system of described filter sensors assembly between described consumer and described outlet manifold and described system sensor measurement.
26. portable system according to claim 14, wherein, described flushing gas comprises Ar, He, N 2, Ar/CO 2, He/CO 2or N 2/ CO 2perhaps inert gas and/or CO 2any combination.
27. portable system according to claim 14, wherein, described pressure source is selected from pump, aspirator or pressurizing vessel.
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