CN103462025A - Health food assisting in reducing blood fat and preparation method and application thereof - Google Patents
Health food assisting in reducing blood fat and preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses health food assisting in reducing blood fat. The health food comprises, by weight, 0.2-0.4 part of natto flour, 1.3-1.8 parts of red yeast rice, 1.8-2.2 parts of phytosterol and 0.1-0.3 part of grape seed extract. The health food is remarkable in blood fat reduction and simple in manufacturing process, and manufacturing cost of the health food is reduced; because raw materials are natural active components, safe and non-poisonous and have no side effects, the health food is edible for a long time. Meanwhile, the invention discloses a preparation method and application of the health food.
Description
Technical field
The present invention relates to a kind of health-care food composition, particularly relate to health food of a kind of auxiliary antilipemic and its preparation method and application.
Background technology
In recent years, along with the variation of diet structure and life style, the incidence of disease of China's lipid disorders in residents is increase trend.According to investigation, current Chinese patients with dyslipidemia is 1.6 hundred million people approximately, in the crowd of adult's illness rate more than 18.6%, 35 years old, have 2,500 ten thousand people to suffer from hypertension and hyperlipemia simultaneously.
High fat of blood is called " stealthy killer " by medical circle, although dyslipidemia does not have manifest symptom, can once morbidity but may cause disability or dead consequence.High fat of blood can cause the various diseases such as artery sclerosis, thrombus, coronary heart disease, and serious chylomicronemia can cause acute pancreatitis, is another mortality disease.In addition, hyperlipemia is also to promote hypertension, anti-sugar to measure important risk factor abnormal, diabetes.Hyperlipemia also can cause fatty liver, cirrhosis, cholelithiasis, pancreatitis, fundus hemorrhage, blind, peripheral vascular disease, limping, hyperuricemia.Tendon shape, nodositas, palm plane and eye socket xanthoma, embryotoxon etc. on every side also can appear in some primary and familial hyperlipemic patients.
The reducing blood lipid series products mainly contains two classes in the market: a class is the medicine with effect for reducing blood fat, and a class is health products, but these products can not meet the demand of people with hyperlipidemia far away, also lacks competitiveness simultaneously.
Medicine still be take as main in the market of reducing blood lipid series products, and the main purchase approach of consumer is hospital.Along with improving constantly of common people's OBD level, blood fat reducing health products market is just persistently overheating.Due to the raising of China's medical and health conditions, population life significantly increases, and high fat of blood and the relevant disease incidence of disease thereof continue to increase, increasing to the demand of blood fat-reducing product.From the growth trend of health-product market, blood fat reducing health products has huge development space in the field, future market.
Summary of the invention
First purpose of the present invention is to provide a kind of health food with auxiliary lipid-lowering function.
For achieving the above object, the present invention is by the following technical solutions:
A kind of health food of auxiliary antilipemic, is characterized in that, this health food is prepared from by the component of following weight portion: 0.2 ~ 0.4 part of natto powder, 1.3 ~ 1.8 parts, red colouring agent for food, also used as a Chinese medicine, 1.8 ~ 2.2 parts of phytosterols, 0.1 ~ 0.3 part of grape seed extract.
Wherein, the weight portion of described component is respectively: 0.3 part of natto powder, 1.5 parts, red colouring agent for food, also used as a Chinese medicine, 2 parts of phytosterols, 0.2 part of grape seed extract.
Wherein, described health food is the Film coated tablets formulation.
Second purpose of the present invention is to provide a kind of method for preparing above-mentioned health food, it is characterized in that, comprises the steps:
(s1) substrate processed: comprise the following steps:
(s11) get the component of following weight portion and add auxiliary material and adhesive mixes and granulated: 0.2 ~ 0.4 part of natto powder, 1.3 ~ 1.8 parts, red colouring agent for food, also used as a Chinese medicine, 1.8 ~ 2.2 parts of phytosterols, 0.1 ~ 0.3 part of grape seed extract, described auxiliary material comprises lactose, dextrin, starch, HPMC, microcrystalline cellulose, silica, PVP;
(s12) particle drying above-mentioned steps obtained, compressing tablet, make substrate;
(s2) dressing processed: specifically comprise:
(s21) with slurry: film coating pre-mix dose is disposed in slurry commanding tank, adds the dressing solvent and be made into dressing solution, stir, standby;
(S22) preheating: substrate is placed in seed-coating machine, opens hot blast, and rotate main frame, substrate is rolled in seed-coating machine;
(s23) spray: regulate spray gun, the dressing solution stirred evenly is sprayed on the substrate of rolling, until color and luster is even, drying, make the health food of Film coated tablets formulation.
Wherein, described film coating pre-mix dose is following one or more mixture: hydroxypropyl methylcellulose (HPMC), hydroxypropyl cellulose (HPC), Eudragit Ⅳ, styrene-ethylene pyridine copolymer, polyvinylpyrrolidone.
Wherein, described dressing solvent is water, ethanol and both variable concentrations mixtures.
The present invention further provides the application of above-mentioned health food in preparing the auxiliary antilipemic product.
Beneficial effect:
From the angle of prevention and health care, this product has its unique advantage place: at first, natto powder, red colouring agent for food, also used as a Chinese medicine, phytosterol and grape seed extract are the active skull cap components extracted from plant, edible safety, have no side effect, without obviously harmful effect, but long-term taking; Secondly, this product component used all has the effect of regulating in various degree blood fat, after making Film coated tablets by macromolecular compound, nonpoisonous and tasteless, and pharmaceutical properties is stable, guarantees pharmaceutical effectiveness, and makes simply, reduces the cost of manufacture of health products.
The specific embodiment
In order to make purpose of the present invention, technical scheme and advantage clearer, below in conjunction with embodiment, the present invention is further elaborated.Should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not intended to limit the present invention.
Natto powder: come from China, the % that composition is moisture 61.8%, crude protein 19.26%, crude fat 8.17%, carbohydrate 6.09, crude fibre 2.2%, ash content 1.86%, as vegetable food, crude protein, fat are the abundantest.Natto powder is the high protein nourishing food, and the alcohol element contained in natto powder can be got rid of part cholesterol in body, the interior acidifying type lipid of decomposer after eating, make abnormal blood pressure recover normal.
Red colouring agent for food, also used as a Chinese medicine: red colouring agent for food, also used as a Chinese medicine is to take long-grained nonglutinous rice as raw material, and the monascus ruber that adopts modern biotechnology to isolate high-quality forms through the liquid deep layer fermenting exquisiteness, is the food additives of a kind of pure natural, safe, the health of intending.The pharmacologist finds in recent years, and red colouring agent for food, also used as a Chinese medicine is used as medicine, and is a kind of outstanding reducing blood lipid, hypotensive natural drug.Record the good recipe of curing the disease that several contain the red colouring agent for food, also used as a Chinese medicine composition in Li Shizhen (1518-1593 A.D.) chief editor's monumental work " herbal guiding principle monascus Zoopagales " book.The China's researcher of Chinese Academy of Sciences exploitation take the lipopenicillinase new drug " olbetam " that red colouring agent for food, also used as a Chinese medicine is raw material, curative effect can match in excellence or beauty with the stanin fat-reducing medicament of u s company exploitation, abroad is referred to as " China he spit of fland ".In addition, the monascus derivative also has very the strong anti-oxidation antitumaous effect of holding concurrently.Along with scientist deepens continuously to the physiology of monascus and the understanding of pharmacological action, ancient red colouring agent for food, also used as a Chinese medicine is expected to become important new drug source.
Phytosterol: be from corn, soybean through physical purification and obtain, have that be of high nutritive value, physiologically active is strong etc., the medicine and health cares such as the katabolism value that prevents the coronary disease atherosclerotic, promotes cholesterol is arranged; Play a part effectively to maintain body inner cholesterol balance, be described as the key of life by scientists.
Grape seed extract: be one of the most efficient antioxidant of the plant origin found so far, in body and in vitro test shows, the antioxidant effect of grape seed extract, be the 30-50 of vitamin C and vitamin E doubly.Superpower anti-oxidant efficiency has the powerful effect of removing free radical, improving body immunity.Proflavanol Grape Seed Extract containing enriching bioflavonoid, be powerful elite molecule, for to Green Tea Extract (free radical) and the health of safeguarding the microfilament blood vessel.Free radical is one of major reason caused aging and many diseases, and tool estimates that the aging of about 80%-90%, degenerative disorders are all relevant with free radical, so grape seed extract is anti-oxidant to human body, improving immunity has splendid effect.
Natto powder of the present invention is the natto of solid fermentation, through freezing vacuum dehumidifying lyophilization, pulverizing, becomes freeze dry powder of fermented soybean.Retained to greatest extent the physiological activator in the natto after vacuum freeze drying.
As a kind of embodiment, in the present invention, all raw materials all can be bought from the market and obtain or utilize existing method to extract.
Embodiment mono-
The health food of the present embodiment auxiliary antilipemic, component by following weight portion is prepared from: 0.2 part of natto powder, 1.3 parts, red colouring agent for food, also used as a Chinese medicine, 1.8 parts of phytosterols, 0.3 part of grape seed extract, also comprise auxiliary material and adhesive that other are appropriate in this health food, auxiliary material is lactose, dextrin, and adhesive is 5% starch slurry.
In the present embodiment, this health food is preferably the Film coated tablets formulation, every 0.85g of finished product, and instructions of taking is every day 2 times, each 3.
The preparation method is as follows:
(s1) substrate processed: specifically comprise step:
(s11) get the component of following weight portion and add appropriate amount of auxiliary materials and adhesive mixes and granulated: 0.2 part of natto powder, 1.3 parts, red colouring agent for food, also used as a Chinese medicine, 1.8 parts of phytosterols, 0.3 part of grape seed extract; Here auxiliary material is lactose, dextrin, and adhesive is 5% starch slurry.
(s12) particle drying above-mentioned steps obtained, compressing tablet, make substrate;
(s2) dressing processed: specifically comprise:
(s21) with slurry: film coating pre-mix dose is disposed in slurry commanding tank, adds water and be made into dressing solution, stir, standby;
(S22) preheating: substrate is placed in seed-coating machine, opens hot blast, and rotate main frame, substrate is rolled in seed-coating machine;
(s23) spray: regulate spray gun, the dressing solution stirred evenly is sprayed on the substrate of rolling, until color and luster is even, drying, make the health food of Film coated tablets formulation.
Embodiment bis-
The health food of the auxiliary antilipemic of the present embodiment, be prepared from by the component of following weight portion: 0.3 part of natto powder, 1.5 parts, red colouring agent for food, also used as a Chinese medicine, 2 parts of phytosterols, 0.1 part of grape seed extract.Also comprise auxiliary material and adhesive that other are appropriate in this health food, auxiliary material is lactose, dextrin, and adhesive comprises the dextrin slurry that weight ratio is 25%.
In the present embodiment, this health food is preferably the Film coated tablets formulation, every 0.85g, and instructions of taking is every day 2 times, each 3.
The preparation method is as follows:
(s1) substrate processed: specifically comprise the following steps:
(s11) component of getting following weight portion adds auxiliary material and adhesive to mix to be granulated: 0.3 part of natto powder, 1.5 parts, red colouring agent for food, also used as a Chinese medicine, 2 parts of phytosterols, 0.1 part of grape seed extract;
(s12) particle drying above-mentioned steps obtained, compressing tablet, make substrate;
(s2) dressing processed: specifically comprise:
(s21) with slurry: film coating pre-mix dose is disposed in slurry commanding tank, and the alcohol solvent that to add volumetric concentration be 75% is made into dressing solution, stirs, standby;
(S22) preheating: substrate is placed in seed-coating machine, opens hot blast, and rotate main frame, substrate is rolled in seed-coating machine;
(s23) spray: regulate spray gun, the dressing solution stirred evenly is sprayed on the substrate of rolling, until color and luster is even, drying, make the health food of Film coated tablets formulation.
Embodiment tri-
The health food of the auxiliary antilipemic of the present embodiment, be prepared from by the component of following weight portion: 0.4 part of natto powder, 1.8 parts, red colouring agent for food, also used as a Chinese medicine, 2.2 parts of phytosterols, 0.2 part of grape seed extract.Also comprise auxiliary material and adhesive that other are appropriate in this health food, auxiliary material is starch, and binder wt is than the dextrin slurry that is 40%.
In the present embodiment, this health food is preferably the Film coated tablets formulation, every 0.85g, and instructions of taking is every day 2 times, each 3.
The preparation method is as follows:
(s1) substrate processed: mainly comprise the following steps:
(s11) component of getting following weight portion adds auxiliary material and adhesive to mix to be granulated: 0.4 part of natto powder, 1.8 parts, red colouring agent for food, also used as a Chinese medicine, 2.2 parts of phytosterols, 0.2 part of grape seed extract make substrate;
(s12) particle drying above-mentioned steps obtained, compressing tablet, make substrate;
(s2) dressing processed: specifically comprise:
(s21) with slurry: film coating pre-mix dose is disposed in slurry commanding tank, adds water and be made into dressing solution, stir, standby;
(S22) preheating: substrate is placed in seed-coating machine, opens hot blast, and rotate main frame, substrate is rolled in seed-coating machine;
(s23) spray: regulate spray gun, the dressing solution stirred evenly is sprayed on the substrate of rolling, until color and luster is even, drying, make the health food of Film coated tablets formulation.
Embodiment tetra-
The health food of the auxiliary antilipemic of the present embodiment, be prepared from by the component of following weight portion: 0.3 part of natto powder, 1.5 parts, red colouring agent for food, also used as a Chinese medicine, 2 parts of phytosterols, 0.2 part of grape seed extract.Also comprise auxiliary material and adhesive that other are appropriate in this health food, auxiliary material comprises that HPMC-E30, microcrystalline cellulose, silica, adhesive are PVPk30.
In the present embodiment, this health food is preferably the Film coated tablets formulation, every 0.85g, and instructions of taking is every day 2 times, each 3.
The preparation method is as follows:
(s1) substrate processed: specifically comprise the following steps:
(s11) component of getting following weight portion adds auxiliary material and adhesive to mix to be granulated: 0.3 part of natto powder, 1.5 parts, red colouring agent for food, also used as a Chinese medicine, 2 parts of phytosterols, 0.2 part of grape seed extract;
(s12) particle drying above-mentioned steps obtained, compressing tablet, make substrate;
(s2) dressing processed: specifically comprise:
(s21) with slurry: film coating pre-mix dose is disposed in slurry commanding tank, and the alcohol solvent that to add volumetric concentration be 75% is made into dressing solution, stirs, standby;
(S22) preheating: substrate is placed in seed-coating machine, opens hot blast, and rotate main frame, substrate is rolled in seed-coating machine;
(s23) spray: regulate spray gun, the dressing solution stirred evenly is sprayed on the substrate of rolling, until color and luster is even, drying, make the health food of Film coated tablets formulation.
In the various embodiments described above, film coating pre-mix dose is following one or more mixture: hydroxypropyl methylcellulose (HPMC), hydroxypropyl cellulose (HPC), Eudragit Ⅳ, styrene-ethylene pyridine copolymer, polyvinylpyrrolidone.
The dressing solvent is water, ethanol or both variable concentrations mixtures, it is to determine according to the character of dressing pre-mixing agent that the dressing solvent is selected, some needs the water configuration, some need to configure with the ethanol water of variable concentrations, as be configured to 75% ethanol water, 60% ethanol water, 40% ethanol water.
The present invention is made into the Film coated tablets formulation by health food, and wherein film coating pre-mix dose is to consist of macromolecular compound, nonpoisonous and tasteless, and patient's long-term taking non-evident effect case shows.According to the character of macromolecule material, also can make respectively the multiple film coating materials such as stomach is molten, enteric, slowly-releasing, controlled release, targeting preparation, to meet different patients' pathology demand, widened the range of application of tablet drug effect on medical skill.The Film coated tablets formulation not only has protection against the tide, lucifuge, taste masking, wear-resisting, and be difficult for to produce sliver, piebald, mildew, is easy to disintegration, has greatly improved the term of validity that dissolution rate, bioavilability, the medicine of medicine are preserved.Because the Film coated tablets volume is little, the sheet type is smooth, it is easier, more convenient that children and women patient are swallowed.Film coated tablets is not all taken restriction to diabetic and sugar avoiding patient yet, has enlarged patient's scope of application.Do not need the sheet process of drying in the air after dressing, just can directly enter packaging process, greatly shortened the production cycle.
The health food of the reducing blood lipid of Film coated tablets formulation of the present invention, preparation technology is simple, and processing ease is easy to grasp, and equipment investment is low, with short production cycle, and prepared pharmaceutical properties is stable, guarantees pharmaceutical effectiveness.
The present invention also discloses the application of a kind of above-mentioned health food in preparing the auxiliary antilipemic product.
By hypolipemic function, test knownly, it is evident in efficacy that the health food that the embodiment of the present invention is made is used for the treatment of high fat of blood.
The zoopery of auxiliary lipid-lowering function of the present invention
1. material
1.1 sample: the health food of getting content in above-mentioned the second embodiment is tested, and every health food is 0.85g, for the oral recommended amounts of human body is every day 2 times, and each 3, become body weight for humans press 60kg calculating, amount to dosage 0.085g/kg.bw.
1.2 experiment equipment, animal and feed
1.2.1 experiment equipment
OLYMPUS AU400 automatic clinical chemistry analyzer, cholesterol (CHOL), triglycerides (TG) kit, HDL-C (HDL-C) kit.
1.2.2 animal used as test
40 of SPF level male SD rats, provided by Beijing Vital River Experimental Animals Technology Co., Ltd.; Animal used as test production unit licensing numbering: the SCXK(capital) 2007-0001; Feed is produced and is provided by Tianjin Huarong's Animal Science Co., Ltd; Experiment condition is barrier environment, 22 ~ 24 ℃ of experimental session experimental situation temperature, humidity 56 ~ 58%; Animal used as test occupancy permit number: SYXK(Tianjin) 2006-0002.
1.2.3 high lipid food
78.8% basal feed, 1% cholesterol, 10% yolk powder, 10% lard, 0.2% cholate.
2. experiment
2.1 dosage design
If basic, normal, high dosage 0.425g/kg.bw, 0.85 g/kg.bw, 2.55g/kg.bw(respectively is equivalent to respectively 5,10,30 times of human body recommended amounts), the tested material configuring time division is not got health-care tablet 8.5g of the present invention, 16g, 48g, edible to animal subject respectively, once a day, continuous 30 days.
2.2 experimental technique
After feeding and to raise rat and observe one week with basal feed, fasting 16 hours, get tail blood, measure serum total cholesterol (TC), triglycerides (TG), HDL-C (HDL-C) with OLYMPUS AU400 automatic clinical chemistry analyzer, take into account TG according to the TC level animal is divided into to 4 groups at random: high fat control group and basic, normal, high three tested material groups.From formal test, each treated animal is used high lipid food instead, by 2.1 dosage, designs to each group animal subject simultaneously, weighs weekly once, in experiment, finishes fasting 16 hours, pulls out the eyeball blood sampling and measures serum TC, TG, HDL-C.
3. data are processed
For data, Excel2003, Spss11.0 software carry out statistical analysis, first data are carried out to the homogeneity of variance test, if variance is neat, adopt one-way analysis of variance totally to compare, find differences again and to carry out comparing in twos between a plurality of dosage groups and control group mean by the Dunnett method.If heterogeneity of variance, carry out suitable variable conversion to initial data, after meeting homogeneity test of variance, by the data after conversion, added up; If do not reach yet the neat purpose of variance after variable conversion, use rank test instead and added up, find totally more variantly, adopt the Tamhane that does not require homogeneity of variance, sT2 checks and compares.
4. result is judged
4.1 the auxiliary lipid-lowering function result is judged
In serum total cholesterol, triglycerides, HDL-C detect, serum total cholesterol, two index positives of triglycerides, can judge this given the test agent auxiliary lipid-lowering function results of animal positive.
4.2 reducing the triglycerides result auxiliary judges
(1) two dosage groups of triglycerides positive as a result; (2) dosage group of triglycerides positive as a result, HDL-C is significantly higher than control group simultaneously, can judge the auxiliary triglycerides results of animal positive that reduces of this given the test agent.
4.3 reducing the serum total cholesterol result auxiliary judges
(1) two dosage groups of serum total cholesterol positive as a result; (2) dosage group of serum total cholesterol positive as a result, HDL-C is significantly higher than control group simultaneously, can judge the auxiliary serum total cholesterol results of animal positive that reduces of this given the test agent.
5. result
5.1 the impact of the present invention on rat body weight
The impact (`x ± S) of table 1 the present invention on rat body weight
| Group | Number of animals (only) | Initial body weight (g) | Body weight in mid-term (g) | Body weight in latter stage (g) | Weightening finish (g) |
| High fat control group | 10 | 162.6±7.3 | 240.7±12.8 | 297.2±25.7 | 134.6±22.0 |
| Low dose group | 10 | 164.7±8.8 | 239.8±17.1 | 293.2±26.7 | 128.5±25.0 |
| Middle dosage group | 10 | 162.5±8.6 | 240.2±20.7 | 296.8±32.4 | 134.3±32.9 |
| High dose group | 10 | 162.5±4.9 | 243.1±10.3 | 295.7±22.1 | 133.2±21.0 |
From table 1, animal subject body weight and experimental session body weight gain and the comparison of high fat control group before and after experiment, no significant difference (P > 0.05), illustrate the present invention on rat body weight without impact.
5.2 the impact of the present invention on Serum TC, TG, HDL-C
Respectively organize Serum TC level (`x ± S) before and after table 2 experiment
| Group | Number of animals (only) | Before experiment (mmol/L) | The P value | After test | The P value |
| High fat control group | 10 | 1.84±0.40 | ? | 2.75±0.32 | ----- |
| Low dose group | 10 | 1.80±0.28 | 0.981 | 2.68±0.56 | 0.960 |
| Middle dosage group | 10 | 1.84±0.20 | ? | 2.36±0.30 | 0.093 |
| High dose group | 10 | 1.82±0.27 | ? | 2.20±0.38 | 0.012★ |
Respectively organize rat blood serum TG level (`x ± S) before and after table 3 experiment
| Group | Number of animals (only) | Before experiment (mmol/L) | The P value | After test | The P value |
| High fat control group | 10 | 0.90±0.43 | ? | 1.81±0.21 | ----- |
| Low dose group | 10 | 0.91±0.31 | 0.999 | 1.80±0.18 | 0.998 |
| Middle dosage group | 10 | 0.93±0.44 | ? | 1.58±0.14 | 0.026★ |
| High dose group | 10 | 0.90±0.41 | ? | 1.56±0.20 | 0.013★ |
Respectively organize rat blood serum HDL-C(`x ± S before and after table 4 experiment)
| Group | Number of animals (only) | Before experiment (mmol/L) | The P value | After test | The P value |
| High fat control group | 10 | 1.23±0.13 | ? | 1.22±0.15 | ? |
| Low dose group | 10 | 1.21±0.11 | 0.772 | 1.25±0.14 | 0.279 |
| Middle dosage group | 10 | 1.26±0.10 | ? | 1.32±0.08 | ? |
| High dose group | 10 | 1.24±0.10 | ? | 1.29±0.12 | ? |
Table 2 ~ 4 are visible, and after experiment, high fat control group serum TC, TG all obviously raise, and relatively front with experiment, difference has conspicuousness (P<0.05), surperficial modeling success.With high fat control group, compare, middle and high dosage group can significantly reduce the rat blood serum triglyceride levels, and high dose group can significantly reduce rat total cholesterol level (P<0.050).
6. sum up
Under this experiment condition, health food of the present invention with 0.425g/kg.bw, 0.85 g/kg.bw, 2.55g/kg.bw dosage eats 30 days to SD level rat, with high fat control group, compare, raise high lipid food rat blood serum triglyceride levels 0.85 g/kg.bw, 2.55g/kg.bw dosage can significantly reduce, 2.55g/kg.bw dosage can significantly reduce raises high lipid food rat blood serum total cholesterol level (P<0.05).According to " health food check and assessment technique standard " (version in 2003), judge, the present invention has auxiliary lipid-lowering function to animal.
The above; be only the present invention's specific embodiment preferably, but protection scope of the present invention is not limited to this, anyly is familiar with in technical scope that those skilled in the art disclose in the present invention; the variation that can expect easily or replacement, within all should being encompassed in protection scope of the present invention.Therefore, protection scope of the present invention should be as the criterion with the protection domain of claim.
Claims (7)
1. the health food of an auxiliary antilipemic, is characterized in that, this health food is prepared from by the component of following weight portion: 0.2 ~ 0.4 part of natto powder, 1.3 ~ 1.8 parts, red colouring agent for food, also used as a Chinese medicine, 1.8 ~ 2.2 parts of phytosterols, 0.1 ~ 0.3 part of grape seed extract.
2. the health food of auxiliary antilipemic according to claim 1, is characterized in that, the weight portion of described component is respectively: 0.3 part of natto powder, 1.5 parts, red colouring agent for food, also used as a Chinese medicine, 2 parts of phytosterols, 0.2 part of grape seed extract.
3. the health food of auxiliary antilipemic according to claim 1 and 2, is characterized in that, described health food is the Film coated tablets formulation.
4. a method for preparing the described health food of claim 3, is characterized in that, comprises the steps:
(s1) substrate processed: comprise the following steps:
(s11) get the component of following weight portion and add auxiliary material and adhesive mixes and granulated: 0.2 ~ 0.4 part of natto powder, 1.3 ~ 1.8 parts, red colouring agent for food, also used as a Chinese medicine, 1.8 ~ 2.2 parts of phytosterols, 0.1 ~ 0.3 part of grape seed extract, described auxiliary material comprises lactose, dextrin, starch, HPMC, microcrystalline cellulose, silica, PVP;
(s12) particle drying above-mentioned steps obtained, compressing tablet, make substrate;
(s2) dressing processed: specifically comprise:
(s21) with slurry: film coating pre-mix dose is disposed in slurry commanding tank, adds the dressing solvent and be made into dressing solution, stir, standby;
(S22) preheating: substrate is placed in seed-coating machine, opens hot blast, and rotate main frame, substrate is rolled in seed-coating machine;
(s23) spray: regulate spray gun, the dressing solution stirred evenly is sprayed on the substrate of rolling, until color and luster is even, drying, make the health food of Film coated tablets formulation.
5. preparation method according to claim 4, it is characterized in that, described film coating pre-mix dose is following one or more mixture: hydroxypropyl methylcellulose (HPMC), hydroxypropyl cellulose (HPC), Eudragit Ⅳ, styrene-ethylene pyridine copolymer, polyvinylpyrrolidone.
6. preparation method according to claim 4, is characterized in that, described dressing solvent is water, ethanol and both variable concentrations mixtures.
7. the application of the described health food of claim 1 ~ 3 any one in preparing the auxiliary antilipemic product.
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| CN103766902A (en) * | 2014-01-10 | 2014-05-07 | 杭州海王生物工程有限公司 | Powder with effect of helping to lower blood lipid and preparation method of powder |
| CN105249451A (en) * | 2015-10-09 | 2016-01-20 | 广州市炜鑫生物科技有限公司 | Nourishment containing natto and red yeast rice and preparation method thereof |
| CN105310075A (en) * | 2015-09-23 | 2016-02-10 | 威海南波湾生物技术有限公司 | Preparation method of natto red yeast rice health care food for assisting in lowering blood lipid |
| CN106376926A (en) * | 2016-08-31 | 2017-02-08 | 成都润馨堂药业有限公司 | Formula and preparation method of hard capsule with assisted blood fat reducing function |
| CN106954798A (en) * | 2017-03-11 | 2017-07-18 | 北京中科卓尔生物科技有限公司 | Red yeast rice natto fine powder and preparation method thereof |
| CN107029136A (en) * | 2017-04-27 | 2017-08-11 | 北京市永康年健康科技有限责任公司 | A kind of red yeast rice natto product and its preparation method and application |
| CN107334151A (en) * | 2017-07-12 | 2017-11-10 | 康道生物（南通）有限公司 | One kind auxiliary reducing blood lipid glad source piece and preparation technology |
| CN108771248A (en) * | 2018-05-17 | 2018-11-09 | 吉林修正健康股份有限公司 | A kind of health-care food for assisting blood fat lowering full of nutrition and preparation method thereof |
| CN109549206A (en) * | 2017-09-26 | 2019-04-02 | 东莞自然衡健康科技有限公司 | A kind of thrombolysis and the functional food and preparation method thereof for preventing cardiovascular disease |
| CN111700271A (en) * | 2020-07-02 | 2020-09-25 | 山东花为酶生物科技有限公司 | Preparation method of functional food for regulating blood fat, removing freckles and reducing blood viscosity |
| CN113730547A (en) * | 2021-09-17 | 2021-12-03 | 江苏协合转化医学研究院有限公司 | Composition for reducing blood fat and dissolving thrombus, preparation method and application thereof |
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| CN103766902A (en) * | 2014-01-10 | 2014-05-07 | 杭州海王生物工程有限公司 | Powder with effect of helping to lower blood lipid and preparation method of powder |
| CN105310075A (en) * | 2015-09-23 | 2016-02-10 | 威海南波湾生物技术有限公司 | Preparation method of natto red yeast rice health care food for assisting in lowering blood lipid |
| CN105249451A (en) * | 2015-10-09 | 2016-01-20 | 广州市炜鑫生物科技有限公司 | Nourishment containing natto and red yeast rice and preparation method thereof |
| CN106376926A (en) * | 2016-08-31 | 2017-02-08 | 成都润馨堂药业有限公司 | Formula and preparation method of hard capsule with assisted blood fat reducing function |
| CN106954798A (en) * | 2017-03-11 | 2017-07-18 | 北京中科卓尔生物科技有限公司 | Red yeast rice natto fine powder and preparation method thereof |
| CN107029136B (en) * | 2017-04-27 | 2018-03-20 | 北京市永康年健康科技有限责任公司 | A kind of red yeast rice natto product and its preparation method and application |
| CN107029136A (en) * | 2017-04-27 | 2017-08-11 | 北京市永康年健康科技有限责任公司 | A kind of red yeast rice natto product and its preparation method and application |
| CN107334151A (en) * | 2017-07-12 | 2017-11-10 | 康道生物（南通）有限公司 | One kind auxiliary reducing blood lipid glad source piece and preparation technology |
| CN109549206A (en) * | 2017-09-26 | 2019-04-02 | 东莞自然衡健康科技有限公司 | A kind of thrombolysis and the functional food and preparation method thereof for preventing cardiovascular disease |
| CN108771248A (en) * | 2018-05-17 | 2018-11-09 | 吉林修正健康股份有限公司 | A kind of health-care food for assisting blood fat lowering full of nutrition and preparation method thereof |
| CN111700271A (en) * | 2020-07-02 | 2020-09-25 | 山东花为酶生物科技有限公司 | Preparation method of functional food for regulating blood fat, removing freckles and reducing blood viscosity |
| CN113730547A (en) * | 2021-09-17 | 2021-12-03 | 江苏协合转化医学研究院有限公司 | Composition for reducing blood fat and dissolving thrombus, preparation method and application thereof |
| CN114209058A (en) * | 2021-12-15 | 2022-03-22 | 本元大健康科技产业(广东)有限公司 | Preparation for preventing hypertension, hyperlipidemia and hyperglycemia and preparation method thereof |
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