CN103446560A - Medicine composition for treating alopecia and preparation method thereof - Google Patents
Medicine composition for treating alopecia and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a medicine composition for treating alopecia and a preparation method thereof. The medicine composition comprises 10-150 parts of ajuga nipponensis, 10-160 parts of psammosilene tunicoides, 10-80 parts of bitter galangal, 10-80 parts of geranium wilfordii, 10-120 parts of radix aconiti agrestis, 10-70 parts of inula cappa, 10-230 parts of radix notoginseng, 10-85 parts of neoalsomitra, 10-100 parts of common yam rhizome, 10-100 parts of paris polyphylla, and 100-2500 parts of ginger juice, and the medicine composition is prepared through steps of extraction, soaking, mixing, and the like. The medicine composition has effects of soothing the liver and regulating vital energy, enriching the blood and invigorating the circulation of blood, and can promote hair to grow and relieve itching.
Description
Technical field
The present invention relates to the Medicinal invention field, be specifically related to pharmaceutical composition of a kind of hair growth and preparation method thereof.
Background technology
According to theory of Chinese medical science, hair and Liver and kidney have substantial connection, kidney storing essence liver master blood, its Hua Fa, Liver and kidney void is asthenia of essence and blood, and hair follicle can not get sufficient nutrition, and a kind of situation is that the synthesis of melanin ability weakens, poliosis occurs, also having so a kind of situation is exactly hair follicle atrophy or necrosis, causes alopecia.Otherwise Liver and kidney is strong, upper Rong Yutou, the dense pitch-black modern medicine of hair is thought, under normal circumstances, abundant blood vessel is arranged in the human hair hair papilla, for hair papilla, ball top section provide sufficient nutrition, thereby the natural on-off cycles of hair growth hormone is synthetic smoothly.Various pessimal stimulations (hormonal readiness impact, nerve stimulus effects etc.) cause the blood vessel generation spasm of supply trichotrophy, make the nutrition function of motion generation obstacle of hair papilla, ball top section.When the formation generation obstacle in hair papilla, ball top section is synthesized in nutrition, although or form because of certain factor, therefore the manufacture meeting with ATP material of cellular energy effect is obstructed.When the ATP as calorie source can't generate, the albumen that therefore can't carry out hair is synthetic, and hair follicle loses vigor, the nutrition of medulla of hair, cortex part reduces, and starts keratinization, and hair follicle starts atrophy or necrosis, hair enters resting stage in a large number, and hair will come off in a large number.
Along with social pressure, constantly increase in recent years and the quickening of rhythm of life, the continuous deterioration of environment, and the dietary habit of bad diet, follow our non-health, subhealth state also to grow with each passing day, the hair loss patient of China is more and more, therefore largely affect people's orthobiosis, seek a kind of good effect, the little medicine of side effect is current research person's urgent problem.
The applicant according to theory of Chinese medical science through for many years research, finally successfully develop a kind of effective, instant effect, cost is low, the medicine had no side effect, have depressed liver-energy dispersing and QI regulating, enriches blood and invigorate blood circulation.Can impel hair growth, the effect such as antipruritic.
Summary of the invention
The pharmaceutical composition that the purpose of this invention is to provide a kind of hair growth.
Another object of the present invention is to provide a kind of preparation method of pharmaceutical composition of hair growth.
The present invention also provides the application of a kind of pharmaceutical composition in hair growth.
The objective of the invention is to be achieved through the following technical solutions:
The crude drug of pharmaceutical composition of the present invention consists of:
Herba boeae clarkeanae 10-150 part, Radix Psammosilenes 10-160 part, bitter Rhizoma Alpiniae Officinarum 10-80 part, Herba Erodii 10-80 part, Radix Aconiti Kusnezoffii 10-120 part, Herba Inulae cappae 10-70 part, Radix Notoginseng 10-230 part, Rhizoma Dioscoreae Nipponicae 10-85 part, Rhizoma dioscoreae 10-100 part, Rhizoma Paridis 10-100 part, Rhizoma Zingiberis Recens juice 100-2500 part.
The crude drug composition of pharmaceutical composition of the present invention is preferably:
Herba boeae clarkeanae 20-140 part, Radix Psammosilenes 20-150 part, bitter Rhizoma Alpiniae Officinarum 15-70 part, Herba Erodii 20-70 part, Radix Aconiti Kusnezoffii 20-110 part, Herba Inulae cappae 20-60 part, Radix Notoginseng 20-220 part, Rhizoma Dioscoreae Nipponicae 20-75 part, Rhizoma dioscoreae 20-90 part, Rhizoma Paridis 20-90 part, Rhizoma Zingiberis Recens juice 110-2300 part.
The crude drug composition of pharmaceutical composition of the present invention is preferably:
Herba boeae clarkeanae 30-130 part, Radix Psammosilenes 30-140 part, bitter Rhizoma Alpiniae Officinarum 20-60 part, Herba Erodii 30-60 part, Radix Aconiti Kusnezoffii 30-100 part, Herba Inulae cappae 30-50 part, Radix Notoginseng 30-210 part, Rhizoma Dioscoreae Nipponicae 30-65 part, Rhizoma dioscoreae 30-80 part, Rhizoma Paridis 30-80 part, Rhizoma Zingiberis Recens juice 120-2200 part.
The crude drug composition of pharmaceutical composition of the present invention is preferably:
Herba boeae clarkeanae 50-110 part, Radix Psammosilenes 50-120 part, bitter Rhizoma Alpiniae Officinarum 25-50 part, Herba Erodii 40-50 part, Radix Aconiti Kusnezoffii 40-90 part, Herba Inulae cappae 35-45 part, Radix Notoginseng 50-190 part, Rhizoma Dioscoreae Nipponicae 40-55 part, Rhizoma dioscoreae 40-70 part, Rhizoma Paridis 40-70 part, Rhizoma Zingiberis Recens juice 130-2100 part.
The crude drug composition of pharmaceutical composition of the present invention is preferably:
85 parts of Herba boeae clarkeanae, 100 parts of Radix Psammosileness, 30 parts of bitter Rhizoma Alpiniae Officinarum, 36 parts of Herba Erodiis, 80 parts of Radix Aconiti Kusnezoffii, 25 parts of Herba Inulae cappaes, 200 parts, Radix Notoginseng, 55 parts of Rhizoma Dioscoreae Nipponicae, 66 parts of Rhizoma dioscoreaes, 62.5 parts of Rhizoma Paridis, 2000 parts of Rhizoma Zingiberis Recens juice.
The preparation method of the pharmaceutical composition of a kind of hair growth provided by the invention, by following steps, formed: the Herba boeae clarkeanae that takes weight portion, Radix Psammosilenes, bitter Rhizoma Alpiniae Officinarum, Herba Erodii, Radix Aconiti Kusnezoffii, Herba Inulae cappae, Radix Notoginseng, Rhizoma Dioscoreae Nipponicae, Rhizoma dioscoreae, Rhizoma Paridis, add water heating extraction 1-5 time that 2-10 doubly measures, each 1.5-4 hour, the extract concentrate drying is pulverized, the 40-80 degree soaking in Chinese liquor of doubly measuring with 2-5 is after 1-10 days, the Rhizoma Zingiberis Recens juice of weight portion is poured into wherein, steep again 1-5 days after mixing, filter, add conventional adjuvant through conventional technique and make the ointment of accepting clinically, granule, capsule, soft capsule, tablet, pill, slow releasing agent, oral liquid, patch, lyophilized injectable powder, drop pill.
The preparation method of the pharmaceutical composition of a kind of hair growth provided by the invention, preferably by following steps, formed: the Herba boeae clarkeanae that takes weight portion, Radix Psammosilenes, bitter Rhizoma Alpiniae Officinarum, Herba Erodii, Radix Aconiti Kusnezoffii, Herba Inulae cappae, Radix Notoginseng, Rhizoma Dioscoreae Nipponicae, Rhizoma dioscoreae, Rhizoma Paridis, the water heating extraction 3 times that adds 5 times of amounts, each 2.5 hours, the extract concentrate drying is pulverized, spend soaking in Chinese liquor after 5 days by 50 of 3 times of amounts, the Rhizoma Zingiberis Recens juice of weight portion is poured into wherein, after mixing, steep again 3 days, filter, add conventional adjuvant through conventional technique and make the ointment of accepting clinically, granule, capsule, soft capsule, tablet, pill, slow releasing agent, oral liquid, patch, lyophilized injectable powder, drop pill.
The preparation method of the pharmaceutical composition of a kind of hair growth provided by the invention, preferably by following steps, formed: the Herba boeae clarkeanae that takes weight portion, Radix Psammosilenes, bitter Rhizoma Alpiniae Officinarum, Herba Erodii, Radix Aconiti Kusnezoffii, Herba Inulae cappae, Radix Notoginseng, Rhizoma Dioscoreae Nipponicae, Rhizoma dioscoreae, Rhizoma Paridis, the water heating extraction 4 times that adds 8 times of amounts, each 3 hours, the extract concentrate drying is pulverized, spend soaking in Chinese liquor after 8 days by 60 of 4 times of amounts, the Rhizoma Zingiberis Recens juice of weight portion is poured into wherein, after mixing, steep again 2 days, filter, add conventional adjuvant through conventional technique and make the spray of accepting clinically, ointment, granule, capsule, soft capsule, tablet, pill, slow releasing agent, oral liquid, patch, lyophilized injectable powder, drop pill.
Described pharmaceutically acceptable carrier or diluent refer to the pharmaceutical carrier of pharmaceutical field routine, are selected from one or more in filler, binding agent, disintegrating agent, lubricant, surfactant or correctives, diluent, wherein:
Described filler is selected from starch, sucrose, lactose, mannitol, sorbitol, xylitol, microcrystalline Cellulose or glucose etc.
Described binding agent is selected from cellulose derivative, alginate, gelatin or polyvinylpyrrolidone etc.
Described disintegrating agent is selected from microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose or cross-linking sodium carboxymethyl cellulose.
Described lubricant is selected from stearic acid, Polyethylene Glycol, calcium carbonate, sodium bicarbonate, micropowder silica gel, Pulvis Talci or magnesium stearate.
Described surfactant is selected from dodecylbenzene sodium sulfonate, stearic acid, Pluronic F68, the fatty acid Pyrusussuriensis is smooth or Polysorbate (tween) etc.
Described correctives is selected from aspartame, Sucralose or saccharin sodium.
Described diluent is Chinese liquor, water etc.
The present invention also provides the application of pharmaceutical composition in hair growth.
The applicant according to theory of Chinese medical science through for many years research, pass through dredging blood vessel, make the QI and blood smoothness, thereby improve the blood circulation of tip under the head hair follicle, regulate brain function, strengthen the nutrition of brain cell, promote ATP synthetic utilization the fast, this multiple stimulation massage can be accelerated the blood circulation of hair follicle part, makes hair papilla obtain sufficient blood supply, thereby the nutrition of the medulla of hair of making, cortex part significantly increases.Like this, the cytotrophy of ball top section improves, and cytoactive strengthens, and division is accelerated, and will be conducive to the hair smooth growth and make the hair blackening, effectively improves alopecia.
The pharmaceutical composition of hair growth provided by the invention has the following advantages:
The present invention is effective, instant effect, and cost is low, has no side effect, and has depressed liver-energy dispersing and QI regulating, enriches blood and invigorates blood circulation.Can impel hair growth, the effect such as antipruritic.
Technique of the present invention is the process route according to the characteristics design of crude drug, adopts rational preparation method to apply its main active, makes therapeutic effect more stable, controlled.
The specific embodiment
Following examples are used for the present invention is described, but are not used for limiting the scope of the invention.
Embodiment 1: the spray of pharmaceutical composition of the present invention
Formula: Herba boeae clarkeanae 85g, Radix Psammosilenes 100g, bitter Rhizoma Alpiniae Officinarum 30g, Herba Erodii 36g, Radix Aconiti Kusnezoffii 80g, Herba Inulae cappae 25g, Radix Notoginseng 200g, Rhizoma Dioscoreae Nipponicae 55g, Rhizoma dioscoreae 66g, Rhizoma Paridis 62.5g, Rhizoma Zingiberis Recens juice 2000g.
Method for making: the Herba boeae clarkeanae, Radix Psammosilenes, bitter Rhizoma Alpiniae Officinarum, Herba Erodii, Radix Aconiti Kusnezoffii, Herba Inulae cappae, Radix Notoginseng, Rhizoma Dioscoreae Nipponicae, Rhizoma dioscoreae, the Rhizoma Paridis that take weight portion, the water heating extraction 2 times that adds 3 times of amounts, each 3 hours, the extract concentrate drying is pulverized, and by 60 of 3 times of amounts, spends soaking in Chinese liquor after 8 days, and the Rhizoma Zingiberis Recens juice of weight portion is poured into wherein, after mixing, steep again 4 days, filter, in the spray bottle of packing into, obtain the application's spray.
Embodiment 2: the capsule of pharmaceutical composition of the present invention
Formula: Herba boeae clarkeanae 10g, Radix Psammosilenes 10g, bitter Rhizoma Alpiniae Officinarum 10g, Herba Erodii 10g, Radix Aconiti Kusnezoffii 10g, Herba Inulae cappae 10g, Radix Notoginseng 10g, Rhizoma Dioscoreae Nipponicae 10g, Rhizoma dioscoreae 10g, Rhizoma Paridis 10g, Rhizoma Zingiberis Recens juice 100g.
Method for making: take Herba boeae clarkeanae, Radix Psammosilenes, bitter Rhizoma Alpiniae Officinarum, Herba Erodii, Radix Aconiti Kusnezoffii, Herba Inulae cappae, Radix Notoginseng, Rhizoma Dioscoreae Nipponicae, Rhizoma dioscoreae, the Rhizoma Paridis of weight portion, add the water heating extraction 3 times of 5 times of amounts, each 2 hours, the extract concentrate drying is pulverized, spend soaking in Chinese liquor after 6 days by 50 of 3.5 times of amounts, the Rhizoma Zingiberis Recens juice of weight portion is poured into wherein, steep again after mixing 3 days, filter, the dextrin and the lactose that add 3 times, mix granulation, drying, incapsulate and obtain the application's capsule.
Embodiment 3: the tablet of pharmaceutical composition of the present invention
Formula: Herba boeae clarkeanae 150g, Radix Psammosilenes 160g, bitter Rhizoma Alpiniae Officinarum 80g, Herba Erodii 80g, Radix Aconiti Kusnezoffii 120g, Herba Inulae cappae 70g, Radix Notoginseng 230g, Rhizoma Dioscoreae Nipponicae 85g, Rhizoma dioscoreae 100g, Rhizoma Paridis 100g, Rhizoma Zingiberis Recens juice 2500g.
Method for making: Herba boeae clarkeanae, Radix Psammosilenes, bitter Rhizoma Alpiniae Officinarum, Herba Erodii, Radix Aconiti Kusnezoffii, Herba Inulae cappae, Radix Notoginseng, Rhizoma Dioscoreae Nipponicae, Rhizoma dioscoreae, Rhizoma Paridis add the water heating extraction 4 times of 8 times of amounts, each 3 hours, the extract concentrate drying is pulverized, spend soaking in Chinese liquor after 8 days by 60 of 4 times of amounts, the Rhizoma Zingiberis Recens juice of weight portion is poured into wherein, steep again after mixing 2 days, filter, add dextrin and the lactose of 4 times of amounts, mix granulation, tabletting, obtain the application's tablet.
Embodiment 4: the granule of pharmaceutical composition of the present invention
Formula: Herba boeae clarkeanae 50g, Radix Psammosilenes 50g, bitter Rhizoma Alpiniae Officinarum 25g, Herba Erodii 40g, Radix Aconiti Kusnezoffii 40g, Herba Inulae cappae 35g, Radix Notoginseng 50g, Rhizoma Dioscoreae Nipponicae 40g, Rhizoma dioscoreae 40g, Rhizoma Paridis 40g, Rhizoma Zingiberis Recens juice 130g.
Method for making: the Herba boeae clarkeanae, Radix Psammosilenes, bitter Rhizoma Alpiniae Officinarum, Herba Erodii, Radix Aconiti Kusnezoffii, Herba Inulae cappae, Radix Notoginseng, Rhizoma Dioscoreae Nipponicae, Rhizoma dioscoreae, the Rhizoma Paridis that take weight portion, water heating extraction 1-5 time that adds 10 times of amounts, each 1.5-4 hour, the extract concentrate drying is pulverized, spend soaking in Chinese liquor after 10 days by 80 of 5 times of amounts, the Rhizoma Zingiberis Recens juice of weight portion is poured into wherein, steeped again after mixing 5 days, filter, the dextrin and the lactose that add 2 times of amounts, mix, granulation, obtain the application's granule.
Embodiment 5: the oral liquid of pharmaceutical composition of the present invention
Formula: Herba boeae clarkeanae 30g, Radix Psammosilenes 30g, bitter Rhizoma Alpiniae Officinarum 20g, Herba Erodii 30g, Radix Aconiti Kusnezoffii 30g, Herba Inulae cappae 30g, Radix Notoginseng 30g, Rhizoma Dioscoreae Nipponicae 30g, Rhizoma dioscoreae 30g, Rhizoma Paridis 30g, Rhizoma Zingiberis Recens juice 110g.
Take Herba boeae clarkeanae, Radix Psammosilenes, bitter Rhizoma Alpiniae Officinarum, Herba Erodii, Radix Aconiti Kusnezoffii, Herba Inulae cappae, Radix Notoginseng, Rhizoma Dioscoreae Nipponicae, Rhizoma dioscoreae, the Rhizoma Paridis of weight portion, add the water heating extraction 4 times of 6 times of amounts, each 3 hours, the extract concentrate drying is pulverized, spend soaking in Chinese liquor after 5 days by 70 of 2.5 times of amounts, the Rhizoma Zingiberis Recens juice of weight portion is poured into wherein, steep again 1-5 days after mixing, filter, add sweeting agent, perfusion, gland, sterilizing, obtain the application's oral liquid.
Experimental example 6: pharmacodynamic experiment
The I experiment material
1.1 trial drug and reagent pharmaceutical composition of the present invention: 0.30g, (the careless prepared slices of Chinese crude drugs company limited of Anguo City, Hebei province gold), lot number: 010201.Alopecia Pill: the 35g/ bottle, Guangzhou is respected and is repaiied swollen minute company limited of a Pharmaceutical, lot number: 001026025.Chlorpheniramine maleate tablets: Linfen, Shanxi Province pharmaceutical factory; lot number two (000206-10 fresh blood health-care capsule: 36 draw/bottles; Guangzhou Chenliji Pharmaceutical Factory produces; lot number: 0001010 cyclophosphamide master penetrates agent: the 200mg/ bottle; Hualian Pharmaceutical Co., Shanghai produces, lot number: 9604040 prednisone acetate tablets: every 5mg, Zhejiang fairy house pharmaceutical factory of medicine medicine limited company; lot number: 9904190 carbonic acid Serpentiss: Britain produces, lot number: 5524671A.
1.2 animal NIH mice, regular grade, body weight 20 ± 2g, male and female dual-purpose, the quality certification number: 99A030.SD rat regular grade, body weight 200 ± 20g, female dual-purpose, the quality certification number: 99A032.By Guangdong Medical Lab Animal Center, provide.Cavia porcellus, body weight 300 ± 50g, female h basket is planted use, and the quality certification number: 00A006, provided by Zhongshan Medical Univ.'s Experimental Animal Center.
2 methods and result
2.1 hair regrowth
2.1.1 the rat that affects on rats hair growth is divided 5 groups at random, every group 12, pharmaceutical composition of the present invention is little, in, heavy dose is respectively by 2,4 times of equivalents of adult's clinical equivalent amount, be 0.626g/kg.1.25g/kg and 2.50g/kg, the administration volume is 10m1/kg, Alopecia Pill is by 2 times of administrations of adult's equivalent, and dosage is 2.7g/kg, and the blank group is to the equal-volume distilled water.The name treated animal is in advance prior to back same area cropping, and the cropping area is 3 * 3cm, in cropping, starts administration the same day, and be administered once every day, continuous 7 days, within the 8th day, at cropping position last time, cuts newborn hair, electronic balance precise weighing.Result shows in pharmaceutical composition of the present invention, heavy dose can obviously promote the cropping rats hair growth, and newborn gross weight amount is apparently higher than matched group (table 1),
Table 1 pharmaceutical composition of the present invention on the rat cropping after the impact of hair growth
| Group | Mus number (only) | Dosage (g/kg | Newborn gross weight amount (mg) |
| The blank group | 12 | ? | 63.1±15.4 |
| This pharmaceutical composition small dose group | 12 | 0.626 | 76.3±31.0 |
| Dosage group in this pharmaceutical composition | 12 | 1.25 | 104.7±51.9 * |
| The heavy dose of group of this pharmaceutical composition | 12 | 2.50 | 107.2±46.8 ** |
| Alopecia Pill | 12 | 2.70 | 100.3±26.9 ** |
Compare * p<0.05 with matched group, * * p<0.01 (lower same)
2.1.2 the Cavia porcellus that affects on the Cavia porcellus hair growth is divided into 5 groups at random, pharmaceutical composition of the present invention is little, in, heavy dose is respectively by 2,4 times of equivalents of adult's clinical equivalent amount, be 0.5g/kg, 1.0g/kg, 2.0g/kg, the gastric infusion volume is 10m1/kg, Alopecia Pill is by 2 times of administrations of adult's equivalent, dosage is 2.15g/kg, and the blank group is to the equal-volume distilled water.Each treated animal is in advance prior to back same area cropping, and the cropping area is 3 * 3cm, in cropping, starts administration the same day, and be administered once every day, continuous 10 days, within the 11st day, at cropping position last time, cuts newborn hair electronic balance precise weighing.Result shows, each dosage of pharmaceutical composition of the present invention all has the effect of certain promotion cropping Cavia porcellus hair growth, and obviously, newborn gross weight amount is apparently higher than matched group (table 2) in heavy dose of effect.
Table 2 pharmaceutical composition of the present invention on the Cavia porcellus cropping after the impact of hair growth
| Group | Mus number (only) | Dosage (g/kg) | Newborn gross weight amount (mg) |
| The blank group | 8 | ? | 83.5±23.7 |
| This pharmaceutical composition small dose group | 8 | 0.5 | 97.2±12.3 |
| Dosage group in this pharmaceutical composition | 8 | 1.0 | 117.7±24.0 |
| The heavy dose of group of this pharmaceutical composition | 8 | 2.0 | 123.0±26.5 ** |
| Alopecia Pill | 8 | 2.15 | 120.3±19.2 ** |
2.1.3 thallium carbonate is caused to the therapeutical effect rat oral gavage thallium carbonate 4mg/kg at molten night of rat depilation model, the next day one-time continuous 16 days, cause rat depilation model, rat skin is divided into to incidence, back, left side, right side and five parts of abdominal part, respectively five parts are graded by staging, the progression addition of five parts is to total mark.By the grouping of total mark situation stratified random. grouping and dosage are the same.Rat is administered once every day, continuous 14 days, within the 15th day, estimates total mark by upper method, compares between being organized.After result shows the treatment of little, the middle dosage group of pharmaceutical composition of the present invention, integration is starkly lower than matched group, shows that it has therapeutical effect (table 3) to pathologic depilation due to thallium carbonate molten night.
Table 3 pharmaceutical composition of the present invention causes the therapeutical effect of rat depilation model to thallium carbonate
Divide 5 groups at random, 10 every group 2.2 guinea pig tissues amine is caused to the Cavia porcellus that affects of the reaction of itching.Medicine group of the present invention is the same to the agent amount, and chlorphenamine is by 2 times of administrations of adult's equivalent, and dosage is 1.72mg/kg, and the blank group is to the equal-volume distilled water.Shave hair to each group right instep of Cavia porcellus before experiment, gastric infusion once.Test the same day, abrade right back instep with coarse sandpaper and shave the hair place, 1 square centimeter of area, after administration of gastric infusion 1 hour, only start to drip at the wound surface place 0.01% 0.05m1/ of histamine phosphate, after this every inferior 3 minutes, press 0.01%0.02%, 0.03%, 0.04%, progressive concentration only is 0.05m1/ at every turn.Directly cause and occur that Cavia porcellus later licks right back foot, take and finally occur that it is itch-threshold that Cavia porcellus later licks the right back histamine phosphate's total amount given when sufficient, record is the itch-threshold of name group relatively.Result shows, with the increasing of pharmaceutical composition dosage of the present invention, itch-threshold increases gradually, in, heavy dose has obvious effect, in Table 4.
Table 4 causes on histamine the impact that Cavia porcellus itches and reacts
| Group | Mus number (only) | Dosage (g/kg) | Itch-threshold (Lg) |
| The blank group | 10 | ? | 18.0±22.1 |
| This pharmaceutical composition small dose group | 10 | 0.5 | 44.0±44.3 |
| Dosage group in this pharmaceutical composition | 10 | 1.0 | 50.0±43.0 * |
| The heavy dose of group of this pharmaceutical composition | 10 | 2.0 | 93.0±92.6 * |
| Chlorphenamine | 10 | 0.00172 | 103.0±93.9 ** |
Be divided at random 6 groups 2.2.2 ring phosphorus phthalein amine (cy) is caused to the effect mice of mice anemia model, group technology and dosage are the same, new proportionately 2 times of administrations of people's equivalent of XUEBAO, and dosage is 1.72mg/kg, start administration after mice group, once a day, 5-7 days wherein, every day lumbar injection Cy100mg/kg, erythrocyte, hemoglobin, leukocyte are surveyed in blood sampling in the 11st day.Result shows: three dosage of pharmaceutical composition of the present invention all are increased significantly the red field born of the same parents of model mice, the effect of leukocyte count purpose, but the effect of raising hemoglobin is not obvious, in Table 5.
The effect of table 5 YANGXUE SHENGFA JIAONANG to mice cyclophosphamide anemia model
The applicant according to theory of Chinese medical science through for many years research, pass through dredging blood vessel, make the QI and blood smoothness, thereby improve the blood circulation of tip under the head hair follicle, regulate brain function, strengthen the nutrition of brain cell, promote ATP synthetic utilization the fast, this multiple stimulation massage can be accelerated the blood circulation of hair follicle part, makes hair papilla obtain sufficient blood supply, thereby the nutrition of the medulla of hair of making, cortex part significantly increases.Like this, the cytotrophy of ball top section improves, and cytoactive strengthens, and division is accelerated, and will be conducive to the hair smooth growth and make the hair blackening, effectively improves alopecia.This pharmaceutical composition has depressed liver-energy dispersing and QI regulating, enriches blood and invigorates blood circulation.Can impel hair growth, the effect such as antipruritic.This research shows, this product not only has first use of promotion to the hair growth of normal rat, Cavia porcellus, and the hair growth of the alopecia rat model due to thallium is also had to obvious facilitation.The posthemorrhagic anemia mice model is improved to the effect of RBC number, content of hemoglobin, cyclophosphamide is caused to the effect that mice anemia model is improved leukocyte and RBC number.In addition, this product also has itching-relieving action.Pointing out medicine composite for curing baldness of the present invention is by the result of many-sided pharmacology comprehensive function.
Experimental example 7: pharmaceutical composition toxicity test of the present invention
1, acute toxicity test
After pharmaceutical composition mouse stomach of the present invention administration, do not find obvious acute toxicity, mice maximum dosage-feeding on the one is 510.2g crude drug/kg, is equivalent to 1090 times of the every consumption per days of clinical adult.
2, long term toxicity test
With large, medium and small three dosage (42.45 of pharmaceutical composition of the present invention, 14.15,4.72g crude drug/kg/ day, be equivalent to respectively 140.35 of the consumption of being grown up, 46.84,15.61 doubly) give the continuous gavage of rat six months, general status, hematology, blood biochemical, routine urinalysis, electrocardiogram, system dissection, organ coefficient and histopathology to rat all have no significant effect, do not find toxic reaction, convalescent period, it was 40.45g/kg/ day that rat non-toxic reaction dosage is provided also without the retardance toxic reaction.
Although, above used general explanation, the specific embodiment and test, the present invention is described in detail, on basis of the present invention, can make some modifications or improvements it, and this will be apparent to those skilled in the art.Therefore, these modifications or improvements, all belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (10)
1. the pharmaceutical composition of a hair growth, is characterized in that being comprised of the crude drug of following weight portion: Herba boeae clarkeanae 10-150 part, Radix Psammosilenes 10-160 part, bitter Rhizoma Alpiniae Officinarum 10-80 part, Herba Erodii 10-80 part, Radix Aconiti Kusnezoffii 10-120 part, Herba Inulae cappae 10-70 part, Radix Notoginseng 10-230 part, Rhizoma Dioscoreae Nipponicae 10-85 part, Rhizoma dioscoreae 10-100 part, Rhizoma Paridis 10-100 part, Rhizoma Zingiberis Recens juice 100-2500 part.
2. the pharmaceutical composition of a kind of hair growth according to claim 1, is characterized in that being comprised of the crude drug of following weight portion: Herba boeae clarkeanae 20-140 part, Radix Psammosilenes 20-150 part, bitter Rhizoma Alpiniae Officinarum 15-70 part, Herba Erodii 20-70 part, Radix Aconiti Kusnezoffii 20-110 part, Herba Inulae cappae 20-60 part, Radix Notoginseng 20-220 part, Rhizoma Dioscoreae Nipponicae 20-75 part, Rhizoma dioscoreae 20-90 part, Rhizoma Paridis 20-90 part, Rhizoma Zingiberis Recens juice 110-2300 part.
3. the pharmaceutical composition of a kind of hair growth according to claim 1, is characterized in that being comprised of the crude drug of following weight portion: Herba boeae clarkeanae 30-130 part, Radix Psammosilenes 30-140 part, bitter Rhizoma Alpiniae Officinarum 20-60 part, Herba Erodii 30-60 part, Radix Aconiti Kusnezoffii 30-100 part, Herba Inulae cappae 30-50 part, Radix Notoginseng 30-210 part, Rhizoma Dioscoreae Nipponicae 30-65 part, Rhizoma dioscoreae 30-80 part, Rhizoma Paridis 30-80 part, Rhizoma Zingiberis Recens juice 120-2200 part.
4. the pharmaceutical composition of a kind of hair growth according to claim 1, is characterized in that being comprised of the crude drug of following weight portion: Herba boeae clarkeanae 50-110 part, Radix Psammosilenes 50-120 part, bitter Rhizoma Alpiniae Officinarum 25-50 part, Herba Erodii 40-50 part, Radix Aconiti Kusnezoffii 40-90 part, Herba Inulae cappae 35-45 part, Radix Notoginseng 50-190 part, Rhizoma Dioscoreae Nipponicae 40-55 part, Rhizoma dioscoreae 40-70 part, Rhizoma Paridis 40-70 part, Rhizoma Zingiberis Recens juice 130-2100 part.
5. the pharmaceutical composition of a kind of hair growth according to claim 1, is characterized in that being comprised of the crude drug of following weight portion: 85 parts of Herba boeae clarkeanae, 100 parts of Radix Psammosileness, 30 parts of bitter Rhizoma Alpiniae Officinarum, 36 parts of Herba Erodiis, 80 parts of Radix Aconiti Kusnezoffii, 25 parts of Herba Inulae cappaes, 200 parts, Radix Notoginseng, 55 parts of Rhizoma Dioscoreae Nipponicae, 66 parts of Rhizoma dioscoreaes, 62.5 parts of Rhizoma Paridis, 2000 parts of Rhizoma Zingiberis Recens juice.
6. according to the preparation method of the described pharmaceutical composition of claim 1-5 any one, it is characterized in that its step is as follows: the Herba boeae clarkeanae that takes weight portion, Radix Psammosilenes, bitter Rhizoma Alpiniae Officinarum, Herba Erodii, Radix Aconiti Kusnezoffii, Herba Inulae cappae, Radix Notoginseng, Rhizoma Dioscoreae Nipponicae, Rhizoma dioscoreae, Rhizoma Paridis, add water heating extraction 1-5 time that 2-10 doubly measures, each 1.5-4 hour, the extract concentrate drying is pulverized, the 40-80 degree soaking in Chinese liquor of doubly measuring with 2-5 is after 1-10 days, the Rhizoma Zingiberis Recens juice of weight portion is poured into wherein, steep again 1-5 days after mixing, filter, add conventional adjuvant through conventional technique and make the ointment of accepting clinically, granule, capsule, soft capsule, tablet, pill, slow releasing agent, oral liquid, patch, lyophilized injectable powder, drop pill.
7. the preparation method of pharmaceutical composition according to claim 6, it is characterized in that its step is as follows: levy and be: the Herba boeae clarkeanae that takes weight portion, Radix Psammosilenes, bitter Rhizoma Alpiniae Officinarum, Herba Erodii, Radix Aconiti Kusnezoffii, Herba Inulae cappae, Radix Notoginseng, Rhizoma Dioscoreae Nipponicae, Rhizoma dioscoreae, Rhizoma Paridis, the water heating extraction 3 times that adds 5 times of amounts, each 2.5 hours, the extract concentrate drying is pulverized, spend soaking in Chinese liquor after 5 days by 50 of 3 times of amounts, the Rhizoma Zingiberis Recens juice of weight portion is poured into wherein, after mixing, steep again 3 days, filter, add conventional adjuvant through conventional technique and make the ointment of accepting clinically, granule, capsule, soft capsule, tablet, pill, slow releasing agent, oral liquid, patch, lyophilized injectable powder, drop pill.
8. the preparation method of pharmaceutical composition according to claim 6, it is characterized in that its step is as follows: the Herba boeae clarkeanae that takes weight portion, Radix Psammosilenes, bitter Rhizoma Alpiniae Officinarum, Herba Erodii, Radix Aconiti Kusnezoffii, Herba Inulae cappae, Radix Notoginseng, Rhizoma Dioscoreae Nipponicae, Rhizoma dioscoreae, Rhizoma Paridis, the water heating extraction 4 times that adds 8 times of amounts, each 3 hours, the extract concentrate drying is pulverized, spend soaking in Chinese liquor after 8 days by 60 of 4 times of amounts, the Rhizoma Zingiberis Recens juice of weight portion is poured into wherein, after mixing, steep again 2 days, filter, add conventional adjuvant through conventional technique and make the spray of accepting clinically, ointment, granule, capsule, soft capsule, tablet, pill, slow releasing agent, oral liquid, patch, lyophilized injectable powder, drop pill.
9. the preparation method of the pharmaceutical composition of a kind of hair growth according to claim 6 is characterized in that: described adjuvant is that pharmaceutically acceptable carrier or diluent form.
10. the application of the described pharmaceutical composition of claim 1-5 any one in hair growth.
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