CN103446560B - Medicine composition for treating alopecia and preparation method thereof - Google Patents
Medicine composition for treating alopecia and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a medicine composition for treating alopecia and a preparation method thereof. The medicine composition comprises 10-150 parts of ajuga nipponensis, 10-160 parts of psammosilene tunicoides, 10-80 parts of bitter galangal, 10-80 parts of geranium wilfordii, 10-120 parts of radix aconiti agrestis, 10-70 parts of inula cappa, 10-230 parts of radix notoginseng, 10-85 parts of neoalsomitra, 10-100 parts of common yam rhizome, 10-100 parts of paris polyphylla, and 100-2500 parts of ginger juice, and the medicine composition is prepared through steps of extraction, soaking, mixing, and the like. The medicine composition has effects of soothing the liver and regulating vital energy, enriching the blood and invigorating the circulation of blood, and can promote hair to grow and relieve itching.
Description
Technical field
The present invention relates to field of medicine invention, be specifically related to pharmaceutical composition of a kind of hair growth and preparation method thereof.
Background technology
According to theory of Chinese medical science, hair and Liver and kidney have substantial connection, the main blood of kidney storing essence liver, its Hua Fa, Liver and kidney void then asthenia of essence and blood, hair follicle can not get sufficient nutrition, and a kind of situation is synthesis of melanin reduced capability, there is poliosis, so also have a kind of situation to be exactly hair follicle atrophy or necrosis, cause alopecia.Otherwise Liver and kidney is strong, upper Rong Yutou, then the dense pitch-black modern medicine of hair is thought, under normal circumstances, has abundant blood vessel in human hair hair papilla, and for hair papilla, ball top portion provide sufficient nutrition, thus natural on-off cycles of hair growth hormone synthesizes smoothly.Various pessimal stimulation (hormonal readiness affects, nerve stimulus effects etc.) causes the blood vessel generation spasm of supply trichotrophy, makes the assimilate translocation function generation obstacle in hair papilla, ball top portion.When the formation generation obstacle of nutrition synthesis in hair papilla, ball top portion, although or formed because of certain factor, therefore the manufacture with the ATP material of cellular energy effect can be obstructed.When the ATP as calorie source cannot generate, therefore cannot carry out the albumen synthesis of hair, hair follicle loses vigor, the nutrition of medulla of hair, cortical section reduces, and start keratinization, hair follicle starts atrophy or necrosis, hair enters resting stage in a large number, and hair will come off in a large number.
In recent years along with social pressure constantly increases the quickening with rhythm of life, the continuous deterioration of environment, and the dietary habit of bad diet, non-health, subhealth state with us also grow with each passing day, the hair loss patient of China gets more and more, largely affect the orthobiosis of people, therefore seek a kind of good effect, the little medicine of side effect is current research person's urgent problem.
The applicant is according to theory of Chinese medical science through studying for many years, and successfully development is a kind of effective finally, and instant effect, cost is low, and the medicine had no side effect, has depressed liver-energy dispersing and QI regulating, enriches blood and invigorates blood circulation.Hair growth, the effect such as antipruritic can be impelled.
Summary of the invention
The object of this invention is to provide a kind of pharmaceutical composition of hair growth.
Another object of the present invention is to provide a kind of preparation method of pharmaceutical composition of hair growth.
Present invention also offers the application of a kind of pharmaceutical composition in hair growth.
The object of the invention is to be achieved through the following technical solutions:
The crude drug of pharmaceutical composition of the present invention consists of:
Herba boeae clarkeanae 10-150 part, Radix Psammosilenes 10-16O part, bitter Rhizoma Alpiniae Officinarum 10-80 part, Herba Erodii 10-80 part, Radix Aconiti Kusnezoffii 10-120 part, Herba Inulae cappae 10-70 part, Radix Notoginseng 10-230 part, Rhizoma Dioscoreae Nipponicae 10-85 part, Rhizoma Dioscoreae 10-100 part, Rhizoma Paridis 10-100 part, Rhizoma Zingiberis Recens juice 100-2500 part.
The crude drug composition of pharmaceutical composition of the present invention is preferably:
Herba boeae clarkeanae 20-140 part, Radix Psammosilenes 20-15O part, bitter Rhizoma Alpiniae Officinarum 15-70 part, Herba Erodii 20-70 part, Radix Aconiti Kusnezoffii 20-110 part, Herba Inulae cappae 20-60 part, Radix Notoginseng 20-220 part, Rhizoma Dioscoreae Nipponicae 20-75 part, Rhizoma Dioscoreae 20-90 part, Rhizoma Paridis 20-90 part, Rhizoma Zingiberis Recens juice 110-2300 part.
The crude drug composition of pharmaceutical composition of the present invention is preferably:
Herba boeae clarkeanae 30-130 part, Radix Psammosilenes 30-14O part, bitter Rhizoma Alpiniae Officinarum 20-60 part, Herba Erodii 30-60 part, Radix Aconiti Kusnezoffii 30-100 part, Herba Inulae cappae 30-50 part, Radix Notoginseng 30-210 part, Rhizoma Dioscoreae Nipponicae 30-65 part, Rhizoma Dioscoreae 30-80 part, Rhizoma Paridis 30-80 part, Rhizoma Zingiberis Recens juice 120-2200 part.
The crude drug composition of pharmaceutical composition of the present invention is preferably:
Herba boeae clarkeanae 50-110 part, Radix Psammosilenes 50-12O part, bitter Rhizoma Alpiniae Officinarum 25-50 part, Herba Erodii 40-50 part, Radix Aconiti Kusnezoffii 40-90 part, Herba Inulae cappae 35-45 part, Radix Notoginseng 50-190 part, Rhizoma Dioscoreae Nipponicae 40-55 part, Rhizoma Dioscoreae 40-70 part, Rhizoma Paridis 40-70 part, Rhizoma Zingiberis Recens juice 130-2100 part.
The crude drug composition of pharmaceutical composition of the present invention is preferably:
Herba boeae clarkeanae 85 parts, Radix Psammosilenes 10O part, bitter Rhizoma Alpiniae Officinarum 30 parts, Herba Erodii 36 parts, Radix Aconiti Kusnezoffii 80 parts, Herba Inulae cappae 25 parts, Radix Notoginseng 200 parts, Rhizoma Dioscoreae Nipponicae 55 parts, Rhizoma Dioscoreae 66 parts, Rhizoma Paridis 62.5 parts, Rhizoma Zingiberis Recens juice 2000 parts.
The preparation method of the pharmaceutical composition of a kind of hair growth provided by the invention, be made up of following steps: the Herba boeae clarkeanae taking weight portion, Radix Psammosilenes, bitter Rhizoma Alpiniae Officinarum, Herba Erodii, Radix Aconiti Kusnezoffii, Herba Inulae cappae, Radix Notoginseng, Rhizoma Dioscoreae Nipponicae, Rhizoma Dioscoreae, Rhizoma Paridis, add water heating extraction 1-5 time of 2-10 times amount, each 1.5-4 hour, extract concentrate drying is pulverized, with the 40-80 degree soaking in Chinese liquor of 2-5 times amount after 1-10 days, the Rhizoma Zingiberis Recens juice of weight portion is poured into wherein, 1-5 days is steeped again after mixing, filter, add customary adjuvant through common process and make the ointment accepted clinically, granule, capsule, soft capsule, tablet, pill, slow releasing agent, oral liquid, patch, lyophilized injectable powder, drop pill.
The preparation method of the pharmaceutical composition of a kind of hair growth provided by the invention, preferably be made up of following steps: the Herba boeae clarkeanae taking weight portion, Radix Psammosilenes, bitter Rhizoma Alpiniae Officinarum, Herba Erodii, Radix Aconiti Kusnezoffii, Herba Inulae cappae, Radix Notoginseng, Rhizoma Dioscoreae Nipponicae, Rhizoma Dioscoreae, Rhizoma Paridis, add the water heating extraction 3 times of 5 times amount, each 2.5 hours, extract concentrate drying is pulverized, with 50 degree of soaking in Chinese liquor of 3 times amount after 5 days, the Rhizoma Zingiberis Recens juice of weight portion is poured into wherein, 3 days are steeped again after mixing, filter, add customary adjuvant through common process and make the ointment accepted clinically, granule, capsule, soft capsule, tablet, pill, slow releasing agent, oral liquid, patch, lyophilized injectable powder, drop pill.
The preparation method of the pharmaceutical composition of a kind of hair growth provided by the invention, preferably be made up of following steps: the Herba boeae clarkeanae taking weight portion, Radix Psammosilenes, bitter Rhizoma Alpiniae Officinarum, Herba Erodii, Radix Aconiti Kusnezoffii, Herba Inulae cappae, Radix Notoginseng, Rhizoma Dioscoreae Nipponicae, Rhizoma Dioscoreae, Rhizoma Paridis, add the water heating extraction 4 times of 8 times amount, each 3 hours, extract concentrate drying is pulverized, with 60 degree of soaking in Chinese liquor of 4 times amount after 8 days, the Rhizoma Zingiberis Recens juice of weight portion is poured into wherein, 2 days are steeped again after mixing, filter, add customary adjuvant through common process and make the spray accepted clinically, ointment, granule, capsule, soft capsule, tablet, pill, slow releasing agent, oral liquid, patch, lyophilized injectable powder, drop pill.
Described pharmaceutically acceptable carrier or diluent refer to the pharmaceutical carrier of pharmaceutical field routine, are selected from one or more in filler, binding agent, disintegrating agent, lubricant, surfactant or correctives, diluent, wherein:
Described filler is selected from starch, sucrose, lactose, mannitol, sorbitol, xylitol, microcrystalline Cellulose or glucose etc.
Described binding agent is selected from cellulose derivative, alginate, gelatin or polyvinylpyrrolidone etc.
Described disintegrating agent is selected from microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose or cross-linking sodium carboxymethyl cellulose.
Described lubricant is selected from stearic acid, Polyethylene Glycol, calcium carbonate, sodium bicarbonate, micropowder silica gel, Pulvis Talci or magnesium stearate.
Described surfactant is selected from smooth or Polysorbate (tween) of dodecylbenzene sodium sulfonate, stearic acid, Pluronic F68, fatty acid Pyrusussuriensis etc.
Described correctives is selected from aspartame, Sucralose or saccharin sodium.
Described diluent is Chinese liquor, water etc.
Present invention also offers the application of pharmaceutical composition in hair growth.
The applicant according to theory of Chinese medical science through studying for many years, pass through dredging blood vessel, make QI and blood smooth, thus the blood circulation of tip under improving head hair follicle, regulate brain function, strengthen the nutrition of brain cell, promote that ATP Fast back-projection algorithm utilizes, the massage of this multiple stimulation can accelerate the blood circulation of hair follicle local, makes hair papilla obtain sufficient blood supply, thus make medulla of hair, the nutrition of cortical section significantly increases.Like this, the cytotrophy in ball top portion improves, and cytoactive strengthens, and division is accelerated, and will be conducive to hair smooth growth and make hair blackening, and effectively improving alopecia.
The pharmaceutical composition of hair growth provided by the invention has the following advantages:
The present invention is effective, instant effect, and cost is low, has no side effect, and has depressed liver-energy dispersing and QI regulating, enriches blood and invigorates blood circulation.Hair growth, the effect such as antipruritic can be impelled.
Technique of the present invention is the process route of the characteristics design according to crude drug, adopts rational preparation method to apply its main active, makes therapeutic effect more stable, controlled.
Detailed description of the invention
Following examples for illustration of the present invention, but are not used for limiting the scope of the invention.
Embodiment 1: the spray of pharmaceutical composition of the present invention
Formula: Herba boeae clarkeanae 85g, Radix Psammosilenes 10Og, bitter Rhizoma Alpiniae Officinarum 30g, Herba Erodii 36g, Radix Aconiti Kusnezoffii 80g, Herba Inulae cappae 25g, Radix Notoginseng 200g, Rhizoma Dioscoreae Nipponicae 55g, Rhizoma Dioscoreae 66g, Rhizoma Paridis 62.5g, Rhizoma Zingiberis Recens juice 2000g.
Method for making: take the Herba boeae clarkeanae of weight portion, Radix Psammosilenes, bitter Rhizoma Alpiniae Officinarum, Herba Erodii, Radix Aconiti Kusnezoffii, Herba Inulae cappae, Radix Notoginseng, Rhizoma Dioscoreae Nipponicae, Rhizoma Dioscoreae, Rhizoma Paridis, add the water heating extraction 2 times of 3 times amount, each 3 hours, extract concentrate drying is pulverized, and after 8 days, pours wherein by the Rhizoma Zingiberis Recens juice of weight portion with 60 degree of soaking in Chinese liquor of 3 times amount, 4 days are steeped again after mixing, filter, load in spray bottle, obtain the spray of the application.
Embodiment 2: the capsule of pharmaceutical composition of the present invention
Formula: Herba boeae clarkeanae 10g, Radix Psammosilenes 10g, bitter Rhizoma Alpiniae Officinarum 10g, Herba Erodii 10g, Radix Aconiti Kusnezoffii 10g, Herba Inulae cappae 10g, Radix Notoginseng 10g, Rhizoma Dioscoreae Nipponicae 10g, Rhizoma Dioscoreae 10g, Rhizoma Paridis 10g, Rhizoma Zingiberis Recens juice 100g.
Method for making: take the Herba boeae clarkeanae of weight portion, Radix Psammosilenes, bitter Rhizoma Alpiniae Officinarum, Herba Erodii, Radix Aconiti Kusnezoffii, Herba Inulae cappae, Radix Notoginseng, Rhizoma Dioscoreae Nipponicae, Rhizoma Dioscoreae, Rhizoma Paridis, add the water heating extraction 3 times of 5 times amount, each 2 hours, extract concentrate drying is pulverized, with 50 degree of soaking in Chinese liquor of 3.5 times amount after 6 days, the Rhizoma Zingiberis Recens juice of weight portion is poured into wherein, 3 days are steeped again after mixing, filter, add dextrin and the lactose of 3 times, mixing, makes granule, drying, incapsulates and obtains the capsule of the application.
Embodiment 3: the tablet of pharmaceutical composition of the present invention
Formula: Herba boeae clarkeanae 150g, Radix Psammosilenes 16Og, bitter Rhizoma Alpiniae Officinarum 80g, Herba Erodii 80g, Radix Aconiti Kusnezoffii 120g, Herba Inulae cappae 70g, Radix Notoginseng 230g, Rhizoma Dioscoreae Nipponicae 85g, Rhizoma Dioscoreae 100g, Rhizoma Paridis 100g, Rhizoma Zingiberis Recens juice 2500g.
Method for making: Herba boeae clarkeanae, Radix Psammosilenes, bitter Rhizoma Alpiniae Officinarum, Herba Erodii, Radix Aconiti Kusnezoffii, Herba Inulae cappae, Radix Notoginseng, Rhizoma Dioscoreae Nipponicae, Rhizoma Dioscoreae, Rhizoma Paridis, adds the water heating extraction 4 times of 8 times amount, each 3 hours, extract concentrate drying is pulverized, after 8 days with 60 degree of soaking in Chinese liquor of 4 times amount, the Rhizoma Zingiberis Recens juice of weight portion is poured into wherein, after mixing, steeps 2 days again, filter, add dextrin and the lactose of 4 times amount, mixing, makes granule, tabletting, obtains the tablet of the application.
Embodiment 4: the granule of pharmaceutical composition of the present invention
Formula: Herba boeae clarkeanae 50g, Radix Psammosilenes 50g, bitter Rhizoma Alpiniae Officinarum 25g, Herba Erodii 40g, Radix Aconiti Kusnezoffii 40g, Herba Inulae cappae 35g, Radix Notoginseng 50g, Rhizoma Dioscoreae Nipponicae 40g, Rhizoma Dioscoreae 40g, Rhizoma Paridis 40g, Rhizoma Zingiberis Recens juice 130g.
Method for making: take the Herba boeae clarkeanae of weight portion, Radix Psammosilenes, bitter Rhizoma Alpiniae Officinarum, Herba Erodii, Radix Aconiti Kusnezoffii, Herba Inulae cappae, Radix Notoginseng, Rhizoma Dioscoreae Nipponicae, Rhizoma Dioscoreae, Rhizoma Paridis, add water heating extraction 1-5 time of 10 times amount, each 1.5-4 hour, extract concentrate drying is pulverized, with 80 degree of soaking in Chinese liquor of 5 times amount after 10 days, the Rhizoma Zingiberis Recens juice of weight portion is poured into wherein, 5 days are steeped again after mixing, filter, add dextrin and the lactose of 2 times amount, mixing, makes granule, obtains the granule of the application.
Embodiment 5: the oral liquid of pharmaceutical composition of the present invention
Formula: Herba boeae clarkeanae 30g, Radix Psammosilenes 30g, bitter Rhizoma Alpiniae Officinarum 20g, Herba Erodii 30g, Radix Aconiti Kusnezoffii 30g, Herba Inulae cappae 30g, Radix Notoginseng 30g, Rhizoma Dioscoreae Nipponicae 30g, Rhizoma Dioscoreae 30g, Rhizoma Paridis 30g, Rhizoma Zingiberis Recens juice 110g.
Take the Herba boeae clarkeanae of weight portion, Radix Psammosilenes, bitter Rhizoma Alpiniae Officinarum, Herba Erodii, Radix Aconiti Kusnezoffii, Herba Inulae cappae, Radix Notoginseng, Rhizoma Dioscoreae Nipponicae, Rhizoma Dioscoreae, Rhizoma Paridis, add the water heating extraction 4 times of 6 times amount, each 3 hours, extract concentrate drying is pulverized, after 5 days with 70 degree of soaking in Chinese liquor of 2.5 times amount, the Rhizoma Zingiberis Recens juice of weight portion is poured into wherein, after mixing, steeps 1-5 days again, filter, add sweeting agent, perfusion, gland, sterilizing, obtains the oral liquid of the application.
Experimental example 6: pharmacodynamic experiment
I experiment material
1.1 trial drugs and reagent pharmaceutical composition of the present invention: 0.30g, (Anguo City, Hebei province Jin Cao prepared slices of Chinese crude drugs company limited), lot number: 010201.Alopecia Pill: 35g/ bottle, Guangzhou is respected and is repaiied a Pharmaceutical Peng Fen company limited, lot number: 001026025.Chlorpheniramine maleate tablets: Linfen, Shanxi Province pharmaceutical factory; lot number two (the new Xue-bao capsules of 000206-10: 36 draw/bottle; Guangzhou Chenliji Pharmaceutical Factory produces; lot number: 0001010 cyclophosphamide master penetrates agent: 200mg/ bottle; Hualian Pharmaceutical Co., Shanghai produces, lot number: 9604040 prednisone acetate tablets: every sheet 5mg, Zhejiang fairy house pharmaceutical factory of medicine medicine limited company; lot number: 9904190 carbonic acid Serpentiss: Britain produces, lot number: 5524671A.
1.2 animal NIH mices, regular grade, the native 2g of body weight 20, male and female dual-purpose, the quality certification number: 99A030.SD rat regular grade, the native 20g of body weight 200, female dual-purpose, the quality certification number: 99A032.There is provided by Guangdong Medical Lab Animal Center.Cavia porcellus, the native 50g of body weight 300, female h basket plants use, and the quality certification number: OOA006, is provided by Zhongshan Medical Univ.'s Experimental Animal Center.
2 methods and result
2.1 hair regrowth
2.1.1 5 groups are divided at random on the rat that affects of rats hair growth, often organize 12, pharmaceutical composition of the present invention is little, in, heavy dose is respectively by adult's clinical equivalent amount 2,4 times of equivalents, i.e. 0.626g/kg.1.25g/kg and 2.50g/kg, administration volume is 10m1/kg, Alopecia Pill is by the 2 times of administrations of adult's equivalent, and dosage is 2.7g/kg, and blank group is to equal-volume distilled water.Name treated animal is in advance prior to back same area cropping, and cropping area is 3 × 3cm, starts administration the same day in cropping, daily once, continuous 7 days, within the 8th day, cuts newborn hair, electronic balance precise weighing at previous cropping position.Result shows in pharmaceutical composition of the present invention, heavy dose can obviously promote cropping rats hair growth, newborn gross weight amount apparently higher than matched group (table 1),
Table 1 pharmaceutical composition of the present invention is on the impact of hair growth after rat cropping
| Group | Mus number (only) | Dosage (g/kg | Newborn gross weight amount (mg) |
| Blank group | 12 | ? | 63.1 soil 15.4 |
| This pharmaceutical composition small dose group | 12 | 0.626 | 76.3 soil 31.0 |
| Dosage group in this pharmaceutical composition | 12 | 1.25 | 104.7 soil 51.9 * |
| The heavy dose of group of this pharmaceutical composition | 12 | 2.50 | 107.2 soil 46.8 ** |
| Alopecia Pill | 12 | 2.70 | 100.3 soil 26.9 ** |
* p<0.05 is compared, * * p<0.01 (lower same) with matched group
2.1.2 5 groups are divided at random on the Cavia porcellus that affects of Cavia porcellus hair growth, pharmaceutical composition of the present invention is little, in, heavy dose is respectively by adult's clinical equivalent amount 2,4 times of equivalents, i.e. 0.5g/kg, 1.Og/kg, 2.Og/kg, gastric infusion volume is 10m1/kg, Alopecia Pill is by the 2 times of administrations of adult's equivalent, dosage is 2.15g/kg, and blank group is to equal-volume distilled water.Each treated animal is in advance prior to back same area cropping, and cropping area is 3 × 3cm, starts administration the same day in cropping, daily once, continuous 10 days, within the 11st day, cuts newborn hair electronic balance precise weighing at previous cropping position.Result shows, each dosage of pharmaceutical composition of the present invention all has the effect of certain promotion cropping Cavia porcellus hair growth, and obviously, newborn gross weight amount is apparently higher than matched group (table 2) in heavy dose of effect.
Table 2 pharmaceutical composition of the present invention is on the impact of hair growth after Cavia porcellus cropping
| Group | Mus number (only) | Dosage (g/kg) | Newborn gross weight amount (mg) |
| Blank group | 8 | ? | 83.5 soil 23.7 |
| This pharmaceutical composition small dose group | 8 | 0.5 | 97.2 soil 12.3 |
| Dosage group in this pharmaceutical composition | 8 | 1.0 | 117.7 soil 24.0 |
| The heavy dose of group of this pharmaceutical composition | 8 | 2.0 | 123.0 soil 26.5 ** |
| Alopecia Pill | 8 | 2.15 | 120.3 soil 19.2 ** |
2.1.3 thallium carbonate is caused to the therapeutical effect rat oral gavage thallium carbonate 4mg/kg at molten night of rat depilation model, the next day one-time continuous 16 days, cause rat depilation model, rat skin is divided into incidence, back, left side, right side and abdominal part five parts, respectively five parts are graded by staging, the progression of five parts is added and is total mark.Divide into groups by total mark situation stratified random. grouping and dosage the same.Rat is administered once every day, continuous 14 days, within the 15th day, evaluates total mark, compare between organizing by upper method.After result shows the treatment of pharmaceutical composition of the present invention little, middle dosage group, integration is starkly lower than matched group, shows that it has therapeutical effect (table 3) to pathologic depilation caused by thallium carbonate molten night.
Table 3 pharmaceutical composition of the present invention causes the therapeutical effect of rat depilation model to thallium carbonate
2.2 cause on guinea pig tissues amine the Cavia porcellus that affects reacted that itches divides 5 groups at random, often organizes 10.Medicine group of the present invention is the same to agent amount, and chlorphenamine is by the 2 times of administrations of adult's equivalent, and dosage is 1.72mg/kg, and blank group is to equal-volume distilled water.Shave hair to before experiment each group of right instep of Cavia porcellus, gastric infusion once.Test the same day, abrade right back instep with coarse sandpaper and shave hair place, area 1 square centimeter, after a gastric infusion administration 1 hour, start at wound surface Chu Di 0.01% histamine phosphate 0.05m1/ only, after this to press 0.01%0.02% every secondary 3 minutes, 0.03%, 0.04%, progressive concentration, is only 0.05m1/ at every turn.Directly cause and occur that Cavia porcellus later licks right back foot, with finally occur Cavia porcellus later lick right back sufficient time histamine phosphate's total amount of giving for itch-threshold, record compares the itch-threshold of name group.Result shows, with the increasing of pharmaceutical composition dosage of the present invention, itch-threshold increases gradually, in, heavy dose has obvious effect, in table 4.
Table 4 on histamine cause Cavia porcellus itch reaction impact
| Group | Mus number (only) | Dosage (g/kg) | Itch-threshold (Lg) |
| Blank group | 10 | ? | 18.0 soil 22.1 |
| This pharmaceutical composition small dose group | 10 | 0.5 | 44.0 soil 44.3 |
| Dosage group in this pharmaceutical composition | 10 | 1.0 | 50.0 soil 43.0 * |
| The heavy dose of group of this pharmaceutical composition | 10 | 2.0 | 93.0 soil 92.6 * |
| Chlorphenamine | 10 | 0.00172 | 103.0 soil 93.9 ** |
2.2.2 6 groups are divided at random to the effects Mice that ring phosphorus phthalein amine (cy) causes mice Anemia model, group technology and dosage the same, the proportionately people's equivalent 2 times of administrations of new XUEBAO, dosage is 1.72mg/kg, administration is started after mice group, once a day, wherein 5-7 days, every day lumbar injection Cy100mg/kg, blood sampling in 11st day surveys erythrocyte, hemoglobin, leukocyte.Result shows: pharmaceutical composition of the present invention three dosage are all increased significantly the red field born of the same parents of model mice, the effect of leukocyte count object, but the effect improving hemoglobin is not obvious, in table 5.
Table 5 YANGXUE SHENGFA JIAONANG is to the effect of mice cyclophosphamide Anemia model
The applicant according to theory of Chinese medical science through studying for many years, pass through dredging blood vessel, make QI and blood smooth, thus the blood circulation of tip under improving head hair follicle, regulate brain function, strengthen the nutrition of brain cell, promote that ATP Fast back-projection algorithm utilizes, the massage of this multiple stimulation can accelerate the blood circulation of hair follicle local, makes hair papilla obtain sufficient blood supply, thus make medulla of hair, the nutrition of cortical section significantly increases.Like this, the cytotrophy in ball top portion improves, and cytoactive strengthens, and division is accelerated, and will be conducive to hair smooth growth and make hair blackening, and effectively improving alopecia.This pharmaceutical composition has depressed liver-energy dispersing and QI regulating, enriches blood and invigorates blood circulation.Hair growth, the effect such as antipruritic can be impelled.This research shows, this product not only has promotion first use to the hair growth of normal rat, Cavia porcellus, and also has obvious facilitation to the hair growth of the alopecia rat model caused by thallium.Posthemorrhagic anemia mice model is improved to the effect of RBC number, content of hemoglobin, the effect that mice Anemia model is improved leukocyte and RBC number is caused to cyclophosphamide.In addition, this product also has itching-relieving action.Medicine composite for curing baldness of the present invention is pointed out to be result by many-sided pharmacology comprehensive function.
Experimental example 7: pharmaceutical composition toxicity test of the present invention
1, acute toxicity test
After pharmaceutical composition mouse stomach of the present invention administration, do not find obvious acute toxicity, mice maximum dosage-feeding on the one is 510.2g crude drug/kg, is equivalent to the every consumption per day of clinical adult 1090 times.
2, long term toxicity test
With large, medium and small three dosage (42.45 of pharmaceutical composition of the present invention, 14.15,4.72g crude drug/kg/ day, be equivalent to 140.35 of consumption of being grown up respectively, 46.84,15.61 times) to the continuous gavage of rat six months, the general status of rat, hematology, blood biochemical analysis, routine urinalysis, electrocardiogram, Systematic anatomy, organ coefficient and histopathology are all had no significant effect, do not find toxic reaction, convalescent period, also without retardance toxic reaction, provides rat non-toxic reaction dosage to be 40.45g/kg/ day.
Although above with general explanation, detailed description of the invention and test, the present invention is described in detail, and on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (8)
1. a pharmaceutical composition for hair growth, is characterized in that being made up of the crude drug of following weight portion: Herba boeae clarkeanae 30-130 part, Radix Psammosilenes 30-14O part, bitter Rhizoma Alpiniae Officinarum 20-60 part, Herba Erodii 30-60 part, Radix Aconiti Kusnezoffii 30-100 part, Herba Inulae cappae 30-50 part, Radix Notoginseng 30-210 part, Rhizoma Dioscoreae Nipponicae 30-65 part, Rhizoma Dioscoreae 30-80 part, Rhizoma Paridis 30-80 part, Rhizoma Zingiberis Recens juice 120-2200 part.
2. the pharmaceutical composition of a kind of hair growth according to claim 1, is characterized in that being made up of the crude drug of following weight portion: Herba boeae clarkeanae 50-110 part, Radix Psammosilenes 50-12O part, bitter Rhizoma Alpiniae Officinarum 25-50 part, Herba Erodii 40-50 part, Radix Aconiti Kusnezoffii 40-90 part, Herba Inulae cappae 35-45 part, Radix Notoginseng 50-190 part, Rhizoma Dioscoreae Nipponicae 40-55 part, Rhizoma Dioscoreae 40-70 part, Rhizoma Paridis 40-70 part, Rhizoma Zingiberis Recens juice 130-2100 part.
3. the pharmaceutical composition of a kind of hair growth according to claim 1, is characterized in that being made up of the crude drug of following weight portion: Herba boeae clarkeanae 85 parts, Radix Psammosilenes 10O part, bitter Rhizoma Alpiniae Officinarum 30 parts, Herba Erodii 36 parts, Radix Aconiti Kusnezoffii 80 parts, Herba Inulae cappae 25 parts, Radix Notoginseng 200 parts, Rhizoma Dioscoreae Nipponicae 55 parts, Rhizoma Dioscoreae 66 parts, Rhizoma Paridis 62.5 parts, Rhizoma Zingiberis Recens juice 2000 parts.
4. the preparation method of the pharmaceutical composition according to any one of claim 1-3, it is characterized in that its step is as follows: the Herba boeae clarkeanae taking weight portion, Radix Psammosilenes, bitter Rhizoma Alpiniae Officinarum, Herba Erodii, Radix Aconiti Kusnezoffii, Herba Inulae cappae, Radix Notoginseng, Rhizoma Dioscoreae Nipponicae, Rhizoma Dioscoreae, Rhizoma Paridis, add water heating extraction 2-4 time of 3-8 times amount, each 2-3 hour, extract concentrate drying is pulverized, with the 50-70 degree soaking in Chinese liquor of 2.5-4 times amount after 5-8 days, the Rhizoma Zingiberis Recens juice of weight portion is poured into wherein, 2-4 days is steeped again after mixing, filter, add customary adjuvant through common process and make the ointment accepted clinically, granule, capsule, soft capsule, tablet, pill, slow releasing agent, oral liquid, patch, lyophilized injectable powder, drop pill.
5. the preparation method of pharmaceutical composition according to claim 4, it is characterized in that its step is as follows: the Herba boeae clarkeanae taking weight portion, Radix Psammosilenes, bitter Rhizoma Alpiniae Officinarum, Herba Erodii, Radix Aconiti Kusnezoffii, Herba Inulae cappae, Radix Notoginseng, Rhizoma Dioscoreae Nipponicae, Rhizoma Dioscoreae, Rhizoma Paridis, add the water heating extraction 3 times of 5 times amount, each 2.5 hours, extract concentrate drying is pulverized, with 50 degree of soaking in Chinese liquor of 3 times amount after 5 days, the Rhizoma Zingiberis Recens juice of weight portion is poured into wherein, 3 days are steeped again after mixing, filter, add customary adjuvant through common process and make the ointment accepted clinically, granule, capsule, tablet, pill, slow releasing agent, oral liquid, patch, lyophilized injectable powder, drop pill.
6. the preparation method of pharmaceutical composition according to claim 4, it is characterized in that its step is as follows: the Herba boeae clarkeanae taking weight portion, Radix Psammosilenes, bitter Rhizoma Alpiniae Officinarum, Herba Erodii, Radix Aconiti Kusnezoffii, Herba Inulae cappae, Radix Notoginseng, Rhizoma Dioscoreae Nipponicae, Rhizoma Dioscoreae, Rhizoma Paridis, add the water heating extraction 4 times of 8 times amount, each 3 hours, extract concentrate drying is pulverized, with 60 degree of soaking in Chinese liquor of 4 times amount after 8 days, the Rhizoma Zingiberis Recens juice of weight portion is poured into wherein, 2 days are steeped again after mixing, filter, add customary adjuvant through common process and make the spray accepted clinically, ointment, granule, capsule, soft capsule, tablet, pill, slow releasing agent, oral liquid, patch, lyophilized injectable powder, drop pill.
7. the preparation method of the pharmaceutical composition of a kind of hair growth according to claim 4, is characterized in that: described adjuvant is pharmaceutically acceptable carrier or diluent composition.
8. the application of the pharmaceutical composition described in any one of claim 1-3 in the product preparing hair growth.
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