CN103446475B - A kind of health product of anti-eye aging and preparation thereof - Google Patents
A kind of health product of anti-eye aging and preparation thereof Download PDFInfo
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Abstract
The invention discloses a kind of health product and preparation thereof of anti-eye aging, by corn extract: 10 ~ 50g, blueberry extract: 10 ~ 50g, Herba Euphrasiae Regelii: 1 ~ 5g, Semen Cassiae: 10 ~ 20g, Fructus Lycii: 10 ~ 20g, sweet Xun: 10 ~ 30g, VE:100 ~ 200mg, VC:100 ~ 300mg, B1:50 ~ 150mg and VA:50 ~ 150mg form, add suitable adjuvant and make effervescent tablet, capsule, granule or chewable tablet respectively, there is the advantage that effect is obvious and cheap.
Description
Technical field
The invention belongs to field of health care products, be specifically related to a kind of compositions of anti-eye aging and preparation and application thereof.
Background technology
Along with improving constantly of people's living standard, people focus on the health care of daily life more, the person more than 600 ten thousand that about has low visual acuity in face of China according to statistics, and the oblique amblyope of child about has 1,000 ten thousand; Adolescent myopia rate reaches 40%; University students's rate of myopia is more than 70%, and have a healthy bright eyes seemingly thing more and more not easily, the eyes that asthenopia causes in addition swell and ache, and itches, sheds tears, view is fuzzy is all annoying people at any time, make " window of soul " seem particularly important.
In ophthalmology outpatient service, often can hear that some young people tell that eyes are dry and astringent, have burning sensation or foreign body sensation, also have ophthalmic bloated individually, headache, sore neck pain, detailed inspection finds that there is groups of people visual deterioration, conjunctival congestion, adjustment force declines, seriously have cornea keratinization, lacrimal secretion reduces, and is diagnosed as asthenopia syndrome.
With this, how effectively solving the daily effective nursing problem to eyes of people, " window of soul " that protect us has become more and more Man's Demands, is also one of current urgent problem in this field simultaneously.
Summary of the invention
The technical problem to be solved in the present invention be in prior art to the health product of asthenopia syndrome or medicine few, the invention provides a kind of health product of anti-eye aging, there is successful, the advantage such as cheap.
The technical solution used in the present invention: the present invention is the health product of anti-eye aging, composed of the following components:
Corn extract: 10 ~ 50g, blueberry extract: 10 ~ 50g, Herba Euphrasiae Regelii: 1 ~ 5g, Semen Cassiae: 10 ~ 20g, Fructus Lycii: 10 ~ 20g, sweet Xun: 10 ~ 30g, VE:100 ~ 200mg, VC:100 ~ 300mg, B1:50 ~ 150mg and VA:50 ~ 150mg.
Further preferably, form by with lower part:
Corn extract: 38g, blueberry extract: 20g, Herba Euphrasiae Regelii: 3g, Semen Cassiae: 15g, Fructus Lycii: 18g, sweet Xun: 12g, VE:150mg, VC:100mg, B1:80mg and VA:120mg.
The preparation of the health product of the anti-eye aging of the present invention is effervescent tablet, capsule, granule or chewable tablet.
Wherein the preparation method of effervescent tablet is: by above-mentioned formula mixed dissolution in ethanol, then add disintegrating agent, filler, carbon dioxide source, fully mix, vacuum granulating drying, sieve, then adds acid source, magnesium stearate mixing, and tabletting, obtains effervescent tablet.
Wherein the preparation method of capsule is: by above-mentioned prescription than fully mixing, add pregelatinized Starch, after mixing, use 8% binding agent, vacuum granulating drying, granulate, mix with the magnesium stearate of total amount 1.0%, encapsulated, obtains capsule.
Wherein the preparation method of granule is: in above-mentioned prescription ratio, wet method fully mixes, vacuum drying, then is ground into fine powder, and add soluble starch and protein sugar mixing, make granule with 50 ~ 90% ethanol, through vacuum drying, namely granulate obtains granule.
Wherein the preparation method of chewable tablet is: by above-mentioned prescription than fully mixing, add adjuvant, sieve successively, soft material processed, pelletize, vacuum drying, granulate, gravity tabletting obtains chewable tablet.
The beneficial effect that the present invention reaches:
(1) corn extract: containing abundant lutein and cryptoxanthin, can reduce the probability that 43% suffers from the change of age-related macular sexually transmitted disease (STD), antagonism eyes are aging; Blueberry extract is containing nutrients such as abundant vitamin, protein and mineral, the anthocyanin pigments of wherein unique preciousness has the effect of maintaining well to the eyes of human body, it can relieving eye strain, improve the vision of people, directly can accelerate retina, the synthesis of rhodopsin and regeneration, allow eyes burst forth vigor brilliance; Herba Euphrasiae Regelii is also called Rhizoma et radix valerianae, principle active component is flavone, it is a kind of very strong antioxidant, can oxygen-derived free radicals effectively in purged body, as anthocyanidin, anthocyanidin can overflow in full stage of oil-control peroxide, this ability of oxidation that stops is more than ten times of vitamin E, this antioxidation can stop degeneration, the aging of cell, anti-eye strain improves vision bright eyes and reproduces, and promotes vision and eye function, helps abatement eye pouch and black eye; Semen Cassiae is also known as " going back gb 1 ", Semen Cassiae contains multivitamin and abundant aminoacid, fat, carbohydrate etc., its health care is subject to people's attention day by day, there is the functions such as clearing away liver-fire, wind-damp dispelling, tonifying kidney and improving eyesight, prevent blurred vision, and Semen Cassiae is rich in vitamin A and zinc, nyctalopia can be prevented and treated; Fructus Lycii contains the required nutrition of the healthy eye such as calcium, ferrum such as abundant carotene, retinol1, B1, B2, C, therefore is good at improving eyesight, so be commonly called as " bright eye ".The blurring of vision that ancient Chinese medicine doctor treatment deficiency of liver-blood, deficiency of kidney-YIN cause and nyctalopia; Sweet Xun and Radix Dauci Sativae, containing abundant carotenoid, soluble sugar, starch, cellulose, multivitamin and multiple mineral element, have the title of " Radix Codonopsis Cardiophyllae ", also containing β-Hu Luo
Bu Su, can reach 50 ~ 170mg/kg, and beta-carotene is vitamin a source, forms vitamin A after hydrolysis, is the indispensable a kind of vitamin of human body, can enhancing development, maintains normal vision, control nyctalopia, xerophthalmia; VE(vitamin E) there is free radical resisting: free radical is extensively present in the reactive group in various chemical reaction, has important function to human normal physiological metabolism; VC(vitamin C) be the nutritional factors of intra-ocular lens, ascorbic intake is not enough, is cause one of cataractous factor, and patient should many vitimin supplement C; B1(vitamin B1) generation of Wernicke syndrome can be prevented; VA:(vitamin A) normal vision function can be maintained, the photoreceptor of eye is staff cell in retina and cone cell.These two kinds of cells all have photopigment, namely feel the rhodopsin of the low light level and the iodopsin of sense high light.Rhodopsin and iodopsin are all made up of opsin and retinal.Rhodopsin is after illumination is penetrated, and 11-cis retinal isomery becomes trans-retinene, and is separated with opsin and eclipsed, and this process claims " bleaching ".If enter dark place, then because disappearing to the insensitive rhodopsin of the low light level, therefore thing can not be seen; Retinal after separation is reduced to all-trans-retinal, changes trans retinyl ester (or tautomerizing to cis) further into and is stored in pigment epithelium.By retinyl ester hydrolytic enzyme in retina, change retinyl ester into trans retinol, through oxidation and isomerization, form 11-cis retinal.Recombine as rhodopsin with albumen, recover the sensitivity to the low light level, thus can see thing in the dark place of certain illumination, this process claims secretly; The retinol discharged by liver and retinol binding protein (RBP) combine, and be combined again, be transported to retina in blood plasma with prealbumin, participate in amphiblestroid photochemical reaction, if vitamin A is sufficient, then the regeneration of rhodopsin soon and completely, therefore dark adaptation is short for recovery time; If hypovitaminosis A, then rhodopsin regeneration slowly and not exclusively, therefore dark adaptation extends recovery time, can produce nyctalopia time serious.
(2) effect of the present invention can be illustrated by following pharmacological evaluation.Pharmacological evaluation:
One, on the impact of rabbit eyes Bulbar conjunctiva microcirculation.
(1) experiment material:
1, animal: rabbit male and female have concurrently, body weight 2.0kg ~ 3.5kg.
2, medicine: medicament prepared by the embodiment of the present invention 1 ~ 5.Medicine configures at use for laboratory distilled water, gastric infusion.
(2) experimental technique:
Adopt rabbit eyes conjunctiva blood capillary fluorimetry.Rabbit 50, male and female half and half, body weight 2.0kg ~ 3.5kg, is divided into 5 groups at random, often organizes 10.The normal saline of matched group gavage same volume; The present invention is gavage embodiment 1 ~ 4 administration 0.5g/kg respectively; Successive administration 7d, every day 1 time, each 10ml/kg, 1h after last administration, the fluorescein sodium normal saline solution 1ml/kg(of ear vein injection 10% is equivalent to 100mg/kg), there is the time of fluorescence in record rabbit conjunctival.Experimental result is shown in Table 1:
Table 1 is on the impact of rabbit eyes Bulbar conjunctiva microcirculation
| Grouping | Animal (only) | Dosage (g/kg) | Fluorescence time of occurrence |
| Matched group | 10 | / | 12.95±2.59 |
| Embodiment 1 | 10 | 0.5 | 10.05±2.34 |
| Embodiment 2 | 10 | 0.5 | 9.56±3.16 |
| Embodiment 3 | 10 | 0.5 | 9.78±2.79 |
| Embodiment 4 | 10 | 0.5 | 9.98±2.54 |
| Embodiment 5 | 10 | 0.5 | 9.36±2.48 |
Experimental result shows: the present invention has obviously acceleration rabbit eyes Bulbar conjunctiva microcirculation blood flow, promotes the microcirculation of eye, improves supply of blood flow.
Two, on the impact of rat galactose cataract model.
(1) experiment material:
1, animal: SD rat, male and female have concurrently, body weight 250g ~ 350g.
2, medicine: medicament prepared by the embodiment of the present invention 1 ~ 5.Medicine configures at use for laboratory distilled water, gastric infusion.
(2) experimental technique:
SD rat, first makes eye examination, selects the normal person of eyes 60, male and female half and half, body weight 250g ~ 350g, random assortment 6 groups, the normal saline of matched group gavage same volume; The present invention is gavage embodiment 1 ~ 4 administration 0.5g/kg respectively; Successive administration 5d, every day 1 time, administration volume 1.5ml/100g, respectively organizes all to D-galactose (half-and-half is mixed in feedstuff) after 5d, continues gastric infusion and normal saline simultaneously, until occur that core is muddy.Every 3d eyes drip mydriatic 1 time, use eye examination with slitlamp microscope, and record enters the time of core muddiness, and experimental result is shown in Table 2:
Table 2 is on the impact of rat galactose cataract model
| Grouping | Animal (only) | Dosage (g/kg) | Muddy formation time |
| Matched group | 10 | / | 20.95±6.59 |
| Embodiment 1 | 10 | 0.5 | 28.42±7.56 |
| Embodiment 2 | 10 | 0.5 | 27.24±8.23 |
| Embodiment 3 | 10 | 0.5 | 29.43±7.49 |
| Embodiment 4 | 10 | 0.5 | 28.98±8.71 |
| Embodiment 5 | 10 | 0.5 | 29.15±7.57 |
Experimental result shows: the inhibitory action of health product of the present invention to the cataractous formation of rat galactose is stronger.
Three, on the impact of glaucoma retinitis optic ganglion cell apoptosis.
(1) experiment material:
1, animal: rabbit male and female have concurrently, body weight 2.0kg ~ 3.5kg.
2, medicine: medicament prepared by the embodiment of the present invention 1 ~ 5.Medicine configures at use for laboratory distilled water, gastric infusion.
(2) experimental technique:
Rabbit 50, male and female half and half, body weight 2.0kg ~ 3.5kg, is divided into 6 groups at random, often organizes 10.After preparing fixing red cell suspension, after every rabbit left eye anterior chamber extracts 0.2ml aqueous humor out, the fixing red cell suspension of injection 0.2ml, causes glaucoma model.Every daily Chloramphenicol Eye Drop antiinflammatory.Experiment starts, the normal saline of matched group gavage same volume; The present invention is gavage embodiment 1 ~ 4 administration 0.5g/kg respectively; Successive administration 36d, every day 1 time, each 10ml/kg, put to death rabbit, win eyeball fast, at angle, Gong Yuan place cuts off cornea, iris and crystalline lens, after getting clean vitreous body as much as possible, paraformaldehyde wall of eyeball being fixed on 4% is at least after 24h, more than running water 15h, fix with the ethanol of 80% again, make TUNEL dye marker, detect apoptosis, om observation, apoptosis cell in counting cells, experimental result is shown in Table 2:
Table 3 is on the impact of glaucoma retinitis optic ganglion cell apoptosis
| Grouping | Animal (only) | Dosage (g/kg) | Muddy formation time |
| Matched group | 10 | / | 6.95±2.59 |
| Embodiment 1 | 10 | 0.5 | 4.95±1.52 |
| Embodiment 2 | 10 | 0.5 | 5.21±2.21 |
| Embodiment 3 | 10 | 0.5 | 5.14±1.95 |
| Embodiment 4 | 10 | 0.5 | 5.24±1.86 |
| Embodiment 5 | 10 | 0.5 | 5.09±2.57 |
Experimental result shows: the protective effect of health product of the present invention to glaucoma retinitis optic ganglion cell apoptosis is strong.
Detailed description of the invention:
Embodiment 1
The health product of the anti-eye aging of the present invention, composed of the following components:
Corn extract: 38g, blueberry extract: 20g, Herba Euphrasiae Regelii: 3g, Semen Cassiae: 15g, Fructus Lycii: 18g, sweet Xun: 12g, VE:150mg, VC:100mg, B1:80mg and VA:120mg.By above-mentioned formula mixed dissolution in ethanol, then add disintegrating agent, filler, carbon dioxide source, fully mix, vacuum granulating drying, sieve, then add acid source, mixing, tabletting, obtains effervescent tablet.
Embodiment 2
The health product of anti-eye aging of the present invention, composed of the following components:
Corn extract: 38g, blueberry extract: 20g, Herba Euphrasiae Regelii: 3g, Semen Cassiae: 15g, Fructus Lycii: 18g, sweet Xun: 12g, VE:150mg, VC:100mg, B1:80mg and VA:120mg.By above-mentioned prescription than fully mixing, add pregelatinized Starch, after mixing, with 8% binding agent vacuum granulation, drying, granulate, mixes with the magnesium stearate of total amount 1.0%, encapsulated, obtains capsule.
Embodiment 3
The health product of a kind of anti-eye aging of the present invention, composed of the following components:
Corn extract: 38g, blueberry extract: 20g, Herba Euphrasiae Regelii: 3g, Semen Cassiae: 15g, Fructus Lycii: 18g, sweet Xun: 12g, VE:150mg, VC:100mg, B1:80mg and VA:120mg.Fully mix in the wet mixing of above-mentioned prescription ratio, vacuum drying, then be ground into fine powder, add soluble starch and protein sugar mixing, make granule with 90% ethanol, through vacuum drying, namely granulate obtains granule.
Embodiment 4
The health product of anti-eye aging of the present invention, is characterized in that: composed of the following components:
Corn extract: 50g, blueberry extract: 50g, Herba Euphrasiae Regelii: 5g, Semen Cassiae: 15g, Fructus Lycii: 20g, sweet Xun: 10g, VE:200mg, VC:300mg, B1:150mg and VA:150mg.By above-mentioned formula mixed dissolution in ethanol, then add disintegrating agent, filler, carbon dioxide source, fully mix, vacuum granulating drying, sieve, then add acid source, magnesium stearate mixing, tabletting, obtains effervescent tablet.
Embodiment 5
The health product of anti-eye aging of the present invention, composed of the following components:
Corn extract: 10g, blueberry extract: 10g, Herba Euphrasiae Regelii: 3g, Semen Cassiae: 10g, Fructus Lycii: 10g, sweet Xun: 10g, VE:100mg, VC:100mg, B1:50mg and VA:50mg.
By above-mentioned prescription than fully mixing, add pregelatinized Starch, after mixing, granulate with 8% binding agent, vacuum drying, granulate, mixes with the magnesium stearate of total amount 1.0%, encapsulated, obtains capsule.
Embodiment 6
The health product of the anti-eye aging of the present invention, composed of the following components:
Corn extract: 38g, blueberry extract: 20g, Herba Euphrasiae Regelii: 3g, Semen Cassiae: 15g, Fructus Lycii: 18g, sweet Xun: 12g, VE:150mg, VC:100mg, B1:80mg and VA:120mg.Fully mix in above-mentioned prescription ratio, add adjuvant, sieve successively, soft material processed, pelletize, vacuum drying, granulate, gravity tabletting obtains chewable tablet.
Claims (7)
1. health product for anti-eye aging, is characterized in that: composed of the following components:
Corn extract: 10 ~ 50g, blueberry extract: 10 ~ 50g, Herba Euphrasiae Regelii: 1 ~ 5g, Semen Cassiae: 10 ~ 20g, Fructus Lycii: 10 ~ 20g, sweet Xun: 10 ~ 30g, VE:100 ~ 200mg, VC:100 ~ 300mg, VB1:50 ~ 150mg and VA:50 ~ 150mg.
2. the health product of anti-eye aging according to claim 1, is characterized in that: form by with lower part:
Corn extract: 38g, blueberry extract: 20g, Herba Euphrasiae Regelii: 3g, Semen Cassiae: 15g, Fructus Lycii: 18g, sweet Xun: 12g, VE:150mg, VC:100mg, VB1:80mg and VA:120mg.
3. the preparation of the health product of anti-eye aging according to claim 1, described preparation is effervescent tablet, capsule, granule or chewable tablet.
4. the preparation of the health product of anti-eye aging according to claim 3, it is characterized in that: the preparation method of effervescent tablet is: by above-mentioned formula mixed dissolution in ethanol, add disintegrating agent, filler, carbon dioxide source again, abundant mixing, vacuum drying, sieves, add acid source again, mixing, tabletting, obtains effervescent tablet.
5. the preparation of the health product of anti-eye aging according to claim 3, it is characterized in that: the preparation method of capsule is: by above-mentioned prescription than fully mixing, add pregelatinized Starch, after mixing, use 8% binding agent, vacuum drying, granulate, mix with the magnesium stearate of total amount 1.0%, encapsulated, obtain capsule.
6. the preparation of the health product of anti-eye aging according to claim 3, it is characterized in that: the preparation method of granule is: by above-mentioned prescription than fully mixing, vacuum drying, be ground into fine powder again, add soluble starch and protein sugar mixing, make granule with 50% ~ 90% ethanol, through vacuum drying, namely granulate obtains granule.
7. the preparation of the health product of anti-eye aging according to claim 3, is characterized in that: the preparation method of chewable tablet is: by above-mentioned prescription than fully mixing, add adjuvant, sieve successively, soft material processed, pelletize, vacuum drying, granulate, tabletting obtains chewable tablet.
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| CN105360855B (en) * | 2015-11-13 | 2018-01-19 | 南京中医药大学 | A kind of beverage with anti-kopiopia and preparation method thereof |
| CN105495589B (en) * | 2015-12-16 | 2018-06-26 | 深圳市东盛堂美妆科技有限公司 | Protect chewable tablets of eyesight and preparation method thereof |
| CN106418512A (en) * | 2016-10-25 | 2017-02-22 | 吉林大学 | Multi-flavor corn effervescent tablets and preparation method |
| CN108157575A (en) * | 2018-01-03 | 2018-06-15 | 江苏海王健康生物科技有限公司 | A kind of pressed candy for alleviating visual fatigue and preparation method and application |
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| CN101229287A (en) * | 2007-11-02 | 2008-07-30 | 郭富凤 | Polynary lycopene preventing and treating eye disease capsule and preparing method thereof |
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| CN101229287A (en) * | 2007-11-02 | 2008-07-30 | 郭富凤 | Polynary lycopene preventing and treating eye disease capsule and preparing method thereof |
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| 中老年保眼有道;许津;《药物与人》;20071130;第42-43页 * |
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