CN103442706A - 用于从组织中除去元素的包含巯基的化合物及其制剂 - Google Patents

用于从组织中除去元素的包含巯基的化合物及其制剂 Download PDF

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Publication number
CN103442706A
CN103442706A CN2012800121240A CN201280012124A CN103442706A CN 103442706 A CN103442706 A CN 103442706A CN 2012800121240 A CN2012800121240 A CN 2012800121240A CN 201280012124 A CN201280012124 A CN 201280012124A CN 103442706 A CN103442706 A CN 103442706A
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China
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group
alkyl
hydrogen
carboxyl
aryl
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Pending
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CN2012800121240A
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English (en)
Chinese (zh)
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博伊德·E·黑利
大卫·A·阿特伍德
尼拉德里·N·古普塔
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University of Kentucky Research Foundation
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University of Kentucky Research Foundation
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/695—Silicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/795—Polymers containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/04—Chelating agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D53/00—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols
    • B01D53/34—Chemical or biological purification of waste gases
    • B01D53/46—Removing components of defined structure
    • B01D53/64—Heavy metals or compounds thereof, e.g. mercury
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2253/00—Adsorbents used in seperation treatment of gases and vapours
    • B01D2253/10—Inorganic adsorbents
    • B01D2253/106—Silica or silicates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2253/00—Adsorbents used in seperation treatment of gases and vapours
    • B01D2253/25—Coated, impregnated or composite adsorbents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2257/00—Components to be removed
    • B01D2257/60—Heavy metals or heavy metal compounds
    • B01D2257/602—Mercury or mercury compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2258/00—Sources of waste gases
    • B01D2258/02—Other waste gases
    • B01D2258/0283—Flue gases
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2258/00—Sources of waste gases
    • B01D2258/02—Other waste gases
    • B01D2258/0283—Flue gases
    • B01D2258/0291—Flue gases from waste incineration plants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Toxicology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Analytical Chemistry (AREA)
  • Environmental & Geological Engineering (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
CN2012800121240A 2011-03-07 2012-01-06 用于从组织中除去元素的包含巯基的化合物及其制剂 Pending CN103442706A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/041,798 2011-03-07
US13/041,798 US8575218B2 (en) 2009-09-28 2011-03-07 Thiol-containing compounds for the removal of elements from tissues and formulations therefor
PCT/US2012/020418 WO2012121798A2 (en) 2011-03-07 2012-01-06 Thiol-containing compounds for the removal of elements from tissues and formulations therefor

Publications (1)

Publication Number Publication Date
CN103442706A true CN103442706A (zh) 2013-12-11

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ID=46798686

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CN2012800121240A Pending CN103442706A (zh) 2011-03-07 2012-01-06 用于从组织中除去元素的包含巯基的化合物及其制剂

Country Status (7)

Country Link
US (1) US8575218B2 (https=)
EP (1) EP2683370A4 (https=)
JP (1) JP2014507470A (https=)
CN (1) CN103442706A (https=)
AU (1) AU2012226279A1 (https=)
RU (1) RU2013141994A (https=)
WO (1) WO2012121798A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
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CN114642681A (zh) * 2022-03-18 2022-06-21 中国科学院长春应用化学研究所 一种聚合物在顺铂解毒中的应用

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US8950583B2 (en) * 2008-12-06 2015-02-10 Ermes Medical Company Limited Method to remove heavy metals from a mammal
JP2013505963A (ja) * 2009-09-28 2013-02-21 ユニヴァーシティ オブ ケンタッキー リサーチ ファウンデイション 汚染された環境から元素を除去するチオール含有化合物およびその使用方法
US8426368B2 (en) * 2010-03-25 2013-04-23 The University Of Kentucky Research Foundation Method of ameliorating oxidative stress and supplementing the diet
GB2524831A (en) 2014-04-04 2015-10-07 Ermes Medical Company Ltd New pharmaceutical use
GB2526623A (en) 2014-05-30 2015-12-02 Ermes Medical Company Ltd New pharmaceutical use
US9802889B2 (en) 2014-12-02 2017-10-31 Covalent Research Technologies, LLC Solid supported trithiol compounds for removing heavy metals from solution, and filtration systems utilizing the compounds
US20160367620A1 (en) 2015-06-19 2016-12-22 Harry B. Demopoulos Glutathione
WO2018025049A1 (en) 2016-08-05 2018-02-08 Emeramed Limited New use of n,n-bis-2-mercaptoethyl isophthalamide
MX2021005888A (es) * 2018-11-26 2021-06-23 Procter & Gamble Preparacion farmaceutica solida que contiene acido lipoico y uso de esta.
EP3976233A4 (en) * 2019-05-29 2023-07-26 Alliance for Sustainable Energy, LLC SEQUESTRATION COMPOSITIONS AND MATERIALS
GB202005057D0 (en) 2020-04-06 2020-05-20 Emeramed Ltd New Use
WO2026037909A1 (en) 2024-08-16 2026-02-19 Emeramed Limited N,n-bis-2-mercaptoethyl isophthalamide for use in the treatment of pain
GB202413573D0 (en) 2024-09-13 2024-10-30 Emeramed Ltd New pharmaceutical use

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US20100227812A1 (en) * 2008-12-06 2010-09-09 Haley Boyd E Method of supplementing the diet and ameliorating oxidative stress
CN102612511A (zh) * 2009-09-28 2012-07-25 肯塔基大学研究基金会 用于从污染的环境中去除元素的含巯基化合物及其使用方法

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US6586600B2 (en) * 2000-12-06 2003-07-01 University Of Kentucky Research Foundation Multidentate sulfur-containing ligands
US20100227812A1 (en) * 2008-12-06 2010-09-09 Haley Boyd E Method of supplementing the diet and ameliorating oxidative stress
CN102612511A (zh) * 2009-09-28 2012-07-25 肯塔基大学研究基金会 用于从污染的环境中去除元素的含巯基化合物及其使用方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114642681A (zh) * 2022-03-18 2022-06-21 中国科学院长春应用化学研究所 一种聚合物在顺铂解毒中的应用
CN114642681B (zh) * 2022-03-18 2023-08-29 中国科学院长春应用化学研究所 一种聚合物在顺铂解毒中的应用

Also Published As

Publication number Publication date
US8575218B2 (en) 2013-11-05
US20110160150A1 (en) 2011-06-30
AU2012226279A1 (en) 2013-09-19
EP2683370A4 (en) 2014-10-15
RU2013141994A (ru) 2015-04-20
WO2012121798A2 (en) 2012-09-13
JP2014507470A (ja) 2014-03-27
EP2683370A1 (en) 2014-01-15

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Application publication date: 20131211