CN103432538A - Chinese herbal preparation for treating hyperlipidemia and preparation method thereof - Google Patents
Chinese herbal preparation for treating hyperlipidemia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese herbal preparation for treating hyperlipidemia and a preparation method thereof. The Chinese herbal preparation is prepared from the following bulk drugs by weight: 80 to 120 parts of Impatiens balsamina L, 50 to 80 parts of red sage root, 50 to 100 parts of hawthorn fruit, 60 to 100 parts of milkvetch root, 20 to 60 parts of ginseng, 10 to 40 parts of ginger, 50 to 100 parts of medicinal cyathula root, 50 to 100 parts of figwort root, 30 to 50 parts of raw ochre and 20 to 30 parts of licorice, wherein Impatiens balsamina L, red sage root, hawthorn fruit and milkvetch root are fresh. The preparation method comprises the following steps: 1, juicing the fresh Impatiens balsamina L and red sage root according to above-mentioned proportions; 2, soaking and decocting the rest bulk drugs and carrying out filtration; and 3, mixing obtained juice with obtained decoction liquid so as to obtain a decoction of the Chinese herbal preparation. The Chinese herbal preparation can promote blood circulation to remove blood stasis, guide descending of deficiency, recover vitality and treat hyperlipidemia caused by heat in the liver, obstructed liver-qi, retention of liver-qi and noxious heat in the blood system of the liver and has the advantages of fast action, a good curative effect and no side effects.
Description
Technical field
The invention belongs to field of Chinese herbal medicine technology, be specifically related to a kind of Chinese medicine preparation that is used for the treatment of hyperlipemia.
Background technology
Hyperlipemia is the title of being used to of abnormalities of sugar/lipid metabolism, mainly refers to that serum total cholesterol (TC) or triglyceride (TG) level are too high and/or serum High Density Lipoprotein Cholesterol (HDL-C) level is too low.In recent years, along with people's revenue growth and living standard continue to improve, great changes will take place for eating patterns, and the high protein of picked-up, hypercholesterolemia and high sugar content food are more and more, thereby cause hyperlipemia colony sharply to increase.Research datas show in a large number, and hyperlipidemia is the risk factor of apoplexy, coronary heart disease, myocardial infarction, sudden death.In addition, hyperlipidemia is also an important risk factor that promotes hypertension, impaired glucose tolerance, diabetes.Hyperlipidemia also can cause fatty liver, liver cirrhosis, cholelithiasis, pancreatitis, retinal hemorrhage, blind, peripheral vascular disease, limping, hyperuricemia.Hyperlipidemia is the Major Risk Factors that causes mankind's atherosclerosis.As common atherosclerosis, have: coronary heart disease (comprising myocardial infarction, angina pectoris and sudden death), cerebral infarction and peripheral vessels thrombotic disease.The sickness rate of these cardiac and cerebral vascular diseases is high, and harm is large, and disease progression is dangerous, and its mortality rate accounts for the half left and right of mankind's general mortality rate.The most widely used Western medicine for the treatment of hyperlipidemia is Statins and fibrate lipid-lowering drugs at present.They are mainly the generation by suppressing certain enzyme in liver and the purpose that effect reaches blood fat reducing, therefore the phenomenon that the transaminase increases can appear in prolonged application; In taking the patient that statins treated, approximately there is 2% patient can occur that slight liver source property transaminase raises, and has certain infringement to liver.Regulate the medicine of blood fat through bile and defecate by affecting cholesterol and bile acid in addition, this class medicine can make bile cholesterol be saturated or hypersaturated state usually, and is easy to form cholelithiasis.In recent years, Chinese medicine is used for the treatment of hyperlipemia and makes remarkable progress, the herbal species of primary treatment hyperlipemia mainly contains zhibituo, Herb Gynostemmae Pentaphylli total glycosides, linoleic acid etc. in the market, but still can not need by satisfying the market, and most dose is large, onset is slow or curative effect is not good enough.
Summary of the invention
The problems referred to above that exist for solving prior art, the object of the present invention is to provide a kind of blood circulation promoting and blood stasis dispelling that has, and draws empty descending, post-equalization gas, treatment because liver has that heat, irritability are not dredged, the Chinese medicine preparation of the hyperlipemia that causes of depression of liver-QI, liver noxious heat in the blood system, rapid-action, good effect, have no side effect.
Another object of the present invention is to provide a kind of this to be used for the treatment of the preparation method of the Chinese medicine preparation of hyperlipemia.
For achieving the above object, the technical solution used in the present invention: this is used for the treatment of the Chinese medicine preparation of hyperlipemia, it is characterized in that being prepared from by the crude drug of following weight parts: Impatientis 80-120 part, Radix Salviae Miltiorrhizae 50-80 part, Fructus Crataegi 50-100 part, Radix Astragali 60-100 part, Radix Ginseng 20-60 part, Rhizoma Zingiberis Recens 10-40 part, river cattle sunset 50-100 part, Radix Scrophulariae 50-100 part, Haematitum 30-50 part, Radix Glycyrrhizae 20-30 part, wherein Impatientis, Radix Salviae Miltiorrhizae, Fructus Crataegi and the Radix Astragali are fresh goods.
This is used for the treatment of the Chinese medicine preparation of hyperlipemia, by the crude drug of following weight parts, is prepared from: 100 parts of Impatientis, 60 parts of Radix Salviae Miltiorrhizaes, 80 parts of Fructus Crataegis, 80 parts of the Radixs Astragali, 30 parts of Radix Ginsengs, 20 parts, Rhizoma Zingiberis Recens, 60 parts of river cattle sunset, 60 parts of Radix Scrophulariaes, 40 parts of Haematitum, 25 parts, Radix Glycyrrhizae.
The preparation method that is used for the treatment of the Chinese medicine preparation of hyperlipemia is characterized in that preparing in the steps below: 1,, according to the proportioning of crude drug, fresh Impatientis, Radix Salviae Miltiorrhizae are squeezed the juice; 2, remaining medicine filters after soaking, decocting; 3, squeeze the juice and decocting liquid mixes, Chinese medicine decoction of the present invention.
Adopt the beneficial effect of technique scheme: this Chinese medicine preparation preparation method that is used for the treatment of hyperlipemia has been broken the conventional method for preparing Chinese medicine, easy and simple to handle, kept the effect of active ingredient in the crude drug comprehensively, thereby made whole preparation reach better curative effect.It is monarch drug that Chinese medicine preparation of the present invention be take fresh Impatientis, Radix Salviae Miltiorrhizae, Fructus Crataegi, blood circulation promoting and blood stasis dispelling is arranged, dry, the effect for the treatment of blood disorders, removing toxic substances, but vessel softening helps metabolism.Take the Radix Astragali, Radix Ginseng, Rhizoma Zingiberis Recens is ministerial drug, and tonifying the lung gas, the high immunologic function of post-equalization air stripping are arranged, and promotes the vim and vigour circulation.Take river Niu Xi, Radix Scrophulariae, Haematitum is adjuvant drug, and promoting blood circulation to restore menstrual flow draws deficiency-heat descending, clear-headed brain.Radix Glycyrrhizae, for making, is concocted all medicines, steadily in order.Said medicine is mutually collaborative, has the effect that reduces blood fat, vessel softening, cures mainly hyperlipemia, vascular hypertension, angiemphraxis, and the coronary heart disease, the brain that cause because of above-mentioned reason are clear-headed, headache, head are risen, the disease such as dizzy.
Impatientis: dispel the wind, invigorate blood circulation, detumescence, pain relieving.Control joint rheumatalgia, traumatic injury, scrofula carbuncle, furuncle.Blood circulation promoting and blood stasis dispelling, diuresis removing toxic substances, the deep effect of stimulating the menstrual flow.
Radix Salviae Miltiorrhizae: promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind.Radix Salviae Miltiorrhizae can make aorta atheromatous plaque formation area obviously reduce, serum total cholesterol, triglyceride, all decreases to some degree.The blood fat that Radix Salviae Miltiorrhizae can suppress the high lipid diet rabbit rises.Find that by research danshensu can also suppress the synthetic of cell endogenous cholesterol.
Fructus Crataegi: invigorating the stomach and promoting digestion, blood circulation promoting and blood stasis dispelling.Fructus Crataegi energy prevention and cure of cardiovascular disease, have blood vessel dilating, heart tonifying, increase coronary flow, improve heart vigor, stimulating central nervous system system, reduce blood pressure and cholesterol, vessel softening and diuresis and sedation; Prevent and treat arteriosclerosis, anti-aging, anticancer effect.Fructus Crataegi also has cardiotonic, also helpful to senile heart disease.Its energy appetite-stimulating indigestion-relieving, offset the meat stagnation effect better especially, in a lot of digestant medicines, all adopted Fructus Crataegi; The immunity of energy enhancing body, have anti-aging, anticancer effect.
The Radix Astragali: the effect that benefiting QI for strengthening the superficies, arresting sweating are admittedly de-, hold in the palm skin ulcer granulation promoting, inducing diuresis to remove edema is arranged.Modern medicine study shows, the Radix Astragali has the enhancing human body immunity function, protects the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.Can eliminate the Jishengshenqiwan albuminuria, strengthen myocardial contraction, regulate blood sugar content.The Radix Astragali can not only coronary artery dilator, improves blood supply of cardiac muscle, improves immunologic function, and process that can delaying cell aging." Radix Astragali and Radix Ginseng, Radix Glycyrrhizae three flavors are the panacea except scorching, that flesh is warm.Taste one void, lung qi first absolutely, must be used Radix Astragali temperature boundary between muscles, beneficial fur, real space between skin and muscles, does not make sweating, with beneficial vigour, mends three warmers." (drawing from Compendium of Material Medica).
Radix Ginseng: strongly invigorating primordial QI, multiple arteries and veins is admittedly de-, invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst, the Fructus Alpiniae Oxyphyllae of calming the nerves.Radix Ginseng has the effect of the choline of plan, and the Radix Ginseng Rubra ether extract starts the of short duration hypotensive effect occurred, Radix Ginseng can cause Ca++ in blood vessel to reduce, and its hypotensive effect is the result of Radix Ginseng to the vascular smooth muscle effect, and the ginsenoside Rb1 has lasting hypotensive effect; Radix Ginseng particularly panaxosideRb2 can improve blood fat, reduces blood cholesterol, triglyceride, rising serum High Density Lipoprotein Cholesterol, reduces atherogenic index, for hyperlipemia, thrombosis and arteriosclerosis, therapeutic value is arranged.
Radix Scrophulariae: there is clearing away heat and cooling blood, removing toxic substances, eliminating stagnation sore-throat relieving, the effect of YIN nourishing.Be used for: the warm febrile disease blood of joining the army, the card of consumption of YIN caused by febrile disease.Clearing away heat and cooling blood is arranged, the effect of removing toxic substances YIN nourishing.Expanding cardiovascular and significant hypotensive effect are arranged.
River Niu Xi: invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards., amenorrhea lump in the abdomen unable for soreness of waist and knee joint, muscles and bones, dizziness due to hyperactivity of liver-YANG.
Haematitum: i.e. Haematitum, the suppressing the hyperactive liver town is contrary, cooling blood for hemostasis." book on Chinese herbal medicine is new again ": the suppressing the hyperactive liver pathogenic fire reducing, control the blood system eliminating blood stasis to promote regeneration of blood, detumescence is reduced phlegm.
Further illustrate effect of the present invention below by clinical test.
1, physical data is observed 120 examples altogether.Be divided into following 2 groups:
Experimental group: male 32 examples, female's 28 examples; The oldest person 65 years old, reckling 37 years old, average 50.6+14.3 year;
The elder of the course of disease 21 years, the shortest person 2 months, average 4.92+3.81; Disease primary symptom integration 14.6+3.72 before treatment.
Matched group: male 29 examples, female's 31 examples, the oldest person 65 years old, reckling 39 years old, average 50.4 ± 15.5 years old; The elder of the course of disease 19 years, the shortest person February, average 4.90+3.81; Disease primary symptom integration 14.6 ± 4.63 before treatment.
Each is organized case sex, age and the course of disease, primary symptom integration and carries out respectively statistical analysis, and difference that there are no significant (P>0.05), illustrate between each group and have comparability.
2 cases are selected
Diagnosis and dialectical standard
The hyperlipemia diagnostic criteria: foundation " the guideline of clinical investigations Western medicine diagnose standard of new Chinese medicine treatment hyperlipemia ": in the normal diet situation, 2 weeks interior 2 lipids detection all meet the one of following condition, can make a definite diagnosis.A, serum cholesterol (TC) >=6.0mmol/L; B, triglyceride (TG) >=1.54mmol/L; High density lipoprotein (HDL-C) male≤1.04mmol/L, women≤1.17mmol/L, as the diagnosis reference conditions.
Inclusive criteria meets above-mentioned hyperlipemia diagnostic criteria person, can include the observation case in.
3 Therapeutic Method
Experimental group takes the disclosed Chinese medicine preparation of the embodiment of the present invention 1, oral, and 3 times/days, each 200ml.It within 15 days, was 1 course for the treatment of.
It is oral that matched group 1 takes Lipocaic Granule, 1 time 1 bag (3g), 3 times on the 1st.It within 30 days, was 1 course for the treatment of.
Each organizes during tested life and the dietary habit kept before medication.But all must not take or adopt in the observation process in hyperlipemia, western drug or other treatment method.
4, criterion of therapeutical effect
The hyperlipemia criterion of therapeutical effect is worked out with reference to " guideline of clinical investigations of new Chinese medicine treatment hyperlipemia ":
(1) clinic control: clinical symptoms, sign disappear, and the every inspection of laboratory recovers normal;
(2) produce effects: clinical symptoms, sign disappear, and lipids detection reaches following wantonly 1 person; TC decline >=20%, TG decline >=40%, HDL-C rising >=0.26mmol/L, TC-HDL-C/HDL-C descends >=20%;
(3) effective: lipids detection reach following wantonly 1 person: TC descend >=10% but<20%, TG descend >=20% but<40%, HDL-C rising >=0.104mmol/L but<0.26mmol/L, TC-HDL-C/HDL-C descend >=10% but<20%;
(4) invalid: symptom, sign and the lipids detection person of being not improved after treatment.
5, therapeutic outcome sees the following form.
| Group | Clinic control | Produce effects | Effectively | Invalid | Obvious effective rate (%) | Total effective rate (%) |
| Experimental group | 36 | 18 | 5 | 1 | 54(90.0) | 59(98.3) |
| Matched group | 30 | 19 | 9 | 2 | 49(81.6) | 58(96.7) |
The above results shows; the claimed Chinese medicine preparation of the present invention has significant curative effect in the treatment of hyperlipemia; obvious effective rate can be respectively up to 81.6%, 90.0%; total effective rate is especially up to 98.3%; be significantly higher than Lipocaic Granule; thereby it is safe, reliable, rapid-action to further illustrate lipid-lowering Chinese medicine preparation of the present invention, and bioavailability is high, be the first-selected good medicine of hyperlipemia.Other embodiment is carried out to same experiment, all draw identical conclusion.
Model case
1, Wang, man, 37 years old, company clerk.Because of long-term work and living and diet irregular, do not get enough athletic exercise in addition and keep healthy, in health check-up, find, blood triglyceride, cholesterol surpass normal value, and the moderate fatty liver are arranged, body fat percentage of liveweight 30%.Adopt Drug therapy of the present invention, and coordinate physical training.After 1 month, blood triglyceride is down to normally, take regular exercise half a year, then health check-up body fat 25%.
2, Lee, man, 58 years old, teacher.Main suit's hypertension 5 years, Lipid increase 1 month, blood pressure 130/80mmHg left and right while examining, at the hospital outpatient TC6.25mmol/L clearly that has a blood test, triglyceride 4.8mmol/L, low-density lipoprotein cholesterol 4.53mmol/L, adopt Drug therapy of the present invention three weeks, and controlling of blood pressure is in 120/80mmHg left and right.Blood fat check: LDL-C 2.13mmol/L, TC 4.19mmol/L, TG 1.57mmol/L, HDL-C 1.48mmol/L.
The specific embodiment
Embodiment 1
This is used for the treatment of the Chinese medicine preparation of hyperlipemia, crude drug by following weight parts is prepared from: 120 parts of Impatientis, 80 parts of Radix Salviae Miltiorrhizaes, 100 parts of Fructus Crataegis, 100 parts of the Radixs Astragali, 60 parts of Radix Ginsengs, 40 parts, Rhizoma Zingiberis Recens, 100 parts of river cattle sunset, 100 parts of Radix Scrophulariaes, 50 parts of Haematitum, 30 parts, Radix Glycyrrhizae, wherein Impatientis, Radix Salviae Miltiorrhizae, Fructus Crataegi and the Radix Astragali are fresh goods.
Preparation method: 1,, according to the proportioning of crude drug, fresh Impatientis, Radix Salviae Miltiorrhizae, Fructus Crataegi, the Radix Astragali are cleaned, the outside moisture content of airing, squeezed the juice; 2, remaining medicine filters after soaking, decocting; 3, squeeze the juice and decocting liquid mixes, Chinese medicine decoction of the present invention.
Embodiment 2
This is used for the treatment of the Chinese medicine preparation of hyperlipemia, crude drug by following weight parts is prepared from: 80 parts of Impatientis, 50 parts of Radix Salviae Miltiorrhizaes, 50 parts of Fructus Crataegis, 60 parts of the Radixs Astragali, 20 parts of Radix Ginsengs, 10 parts, Rhizoma Zingiberis Recens, 50 parts of river cattle sunset, 50 parts of Radix Scrophulariaes, 30 parts of Haematitum, 20 parts, Radix Glycyrrhizae, wherein Impatientis, Radix Salviae Miltiorrhizae, Fructus Crataegi and the Radix Astragali are fresh goods.Preparation method as described in Example 1.
Embodiment 3
This is used for the treatment of the Chinese medicine preparation of hyperlipemia, by the crude drug of following weight parts, is prepared from: 100 parts of Impatientis, 60 parts of Radix Salviae Miltiorrhizaes, 80 parts of Fructus Crataegis, 80 parts of the Radixs Astragali, 30 parts of Radix Ginsengs, 20 parts, Rhizoma Zingiberis Recens, 60 parts of river cattle sunset, 60 parts of Radix Scrophulariaes, 40 parts of Haematitum, 25 parts, Radix Glycyrrhizae.Preparation method as described in Example 1.
Claims (3)
1. a Chinese medicine preparation that is used for the treatment of hyperlipemia, it is characterized in that being prepared from by the crude drug of following weight parts: Impatientis 80-120 part, Radix Salviae Miltiorrhizae 50-80 part, Fructus Crataegi 50-100 part, Radix Astragali 60-100 part, Radix Ginseng 20-60 part, Rhizoma Zingiberis Recens 10-40 part, river cattle sunset 50-100 part, Radix Scrophulariae 50-100 part, Haematitum 30-50 part, Radix Glycyrrhizae 20-30 part, wherein Impatientis, Radix Salviae Miltiorrhizae, Fructus Crataegi and the Radix Astragali are fresh goods.
2. the Chinese medicine preparation that is used for the treatment of hyperlipemia according to claim 1, is characterized in that being prepared from by the crude drug of following weight parts: 100 parts of Impatientis, 60 parts of Radix Salviae Miltiorrhizaes, 80 parts of Fructus Crataegis, 80 parts of the Radixs Astragali, 30 parts of Radix Ginsengs, 20 parts, Rhizoma Zingiberis Recens, 60 parts of river cattle sunset, 60 parts of Radix Scrophulariaes, 40 parts of Haematitum, 25 parts, Radix Glycyrrhizae.
3. the preparation method that is used for the treatment of the Chinese medicine preparation of hyperlipemia according to claim 1 is characterized in that preparing in the steps below: 1 ﹚, according to the proportioning of crude drug, squeeze the juice fresh Impatientis, Radix Salviae Miltiorrhizae; 2 ﹚, remaining medicine filter after soaking, decocting; 3 ﹚, squeeze the juice and decocting liquid mixes, Chinese medicine decoction of the present invention.
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| CN101584850A (en) * | 2009-06-03 | 2009-11-25 | 柴成存 | Fruit vinegar ginkgo oral liquid Chinese medicinal composition and preparation method thereof |
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2013
- 2013-07-12 CN CN201310290997.4A patent/CN103432538B/en active Active
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| CN1103302A (en) * | 1993-12-01 | 1995-06-07 | 董兴武 | Hypolipemic and heart tonifying capsule and preparing process thereof |
| CN1307884A (en) * | 2000-11-29 | 2001-08-15 | 段青松 | Angitis treating medicine |
| CN1712056A (en) * | 2005-06-28 | 2005-12-28 | 青岛国风药业股份有限公司 | Medicinal composition, preparation and quality control thereof |
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