CN102727780B - Method for preparing ointment for treating ovarian cyst - Google Patents

Abstract

The invention discloses a method for preparing an ointment for treating ovarian cyst, and is used for solving the treatment problem of ovarian cyst. The raw material drugs comprise: radix paeoniae alb, herbof paniculate spotflower, angelica sinensis, radix ranunculi ternati, immature bitter orange, semen coicis, dried tangerine peel, rhizoma alismatis, cortex moutan, poria cocos, pseudobulbus cremastrae seu pleiones, rhizoma cyperi, herba patriniae, Chinese honeylocust spine, towel gourd vegetable sponge, angelica dahurica, amur corktree bark, manis pentadactyla and prunus persica batsch. The method is characterized by comprising the following steps of: crushing the dried tangerine peel, the herbof paniculate spotflower, the rhizoma cyperi, the herba patriniae and the immature bitter orange to obtain a mixture; (2) decocting the radix paeoniae alb, the angelica sinensis, the radix ranunculi ternate, the semen coicis, the cortex moutan, the rhizoma alismatis, the poria cocos, the pseudobulbus cremastrae seu pleiones, the Chinese honeylocust spine, the angelica dahurica, the amur corktree bark, the manis pentadactyla and the prunus persica batsch with water, precipitating with alcohol, drying and crushing, so the primary material is obtained; (3) crushing the prunus persica batsch powder into fine powder; (4) heating vegetable oil and pouring the mixture for 5-10 minutes to filter the oil; and (5) heating the filtered oil, pouring the primary material for 5-10 minutes to filter the oil, cooling, adding prunus persica batsch fine powder, decocting to obtain a state that the oil drop is of a bead shape to remove infectious water, cooling and sub-packaging. Clinical experiments show that the ointment for treating ovarian cyst has the characteristics of good curative effect and higher safety, and is worth being clinically applied and popularized.

Description

A kind of preparation method for the treatment of ovarian cyst ointment

Technical field

The present invention relates to the field of Chinese medicines, be specifically related to treat the preparation method of ovarian cyst ointment.

Background technology

Ovarian cyst belongs to a kind of of ovarian tumor broadly, the various ages all can be ill, but the most common with the women of 20 ~ 50 years old, female sex organs kinds of tumor, there is various character and form, that is: unitary type or mixed type, a side or bilateral, capsule or substance, optimum or pernicious, wherein common with capsule, and the degree of malignant change is very high.Early diagnosis difficulty, when medical, 70% has belonged to late period, seldom can obtain early treatment, and within 5 years, survival rate is hovered all the time 20 ~ 30%, is to threaten one of the most serious malignant tumor of women's life.The treatment key of ovarian cyst is mainly the active treatment of optimum phase, and benign ovarian cyst therapeutic scheme is cyst diameter, if cyst diameter is greater than 5 centimetres, generally needs operative treatment.And be less than 2 centimetres as cyst diameter, no evidence is pointed out the words of tumor again, because operation has necessarily traumatic, postoperatively may form new adhesion, especially the normal and surrounding tissue adhesion of chocolate cyst of ovary, operation is extractd more difficult completely, and cyst is easily broken and caused diffusion, preferably takes traditional Chinese medical science expectant treatment.Traditional Chinese medical science expectant treatment is many, and from the long-pending knot thirty years of age of blood stasis, the rule for the treatment of adopts the method for removing blood stasis more, as adopted Radix Et Rhizoma Rhei et Eupolyphaga Seu Steleophaga Pilulae to treat.But the cyst of moderate (2 ~ 5 centimetres of diameters) simple medication is difficult to make cyst to disappear, and often treats and is unsuccessfully forced to the operative treatment of being in hospital, costly.

In a patent of invention < < pharmaceutical composition for the treatment of ovarian cyst of applying on the same day with applicant and preparation method thereof > >, a kind of pharmaceutical composition for the treatment of ovarian cyst is disclosed, the finished product of gained is capsule formulation, but in clinical practice, because ovarian cyst treatment cycle is long, patient's long-term taking oral drugs of gastrointestinal weakness or gastrointestinal sensitivity easily produce the untoward reaction such as gastrointestinal irritation.Therefore the vertical purport of the present invention is in seeking a kind of effective parenteral noinvasive route of administration.

Summary of the invention

Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly and the preparation method of the treatment ovarian cyst ointment that side effect is little.

The technical scheme that the present invention solves its technical problem is: a kind of preparation method for the treatment of ovarian cyst ointment, the crude drug of described ovarian cyst ointment comprises: the Radix Paeoniae Alba, Herba Spilanthis Acmellae, Radix Angelicae Sinensis, Radix Ranunculi Ternati, Fructus Aurantii Immaturus, Semen Coicis, Pericarpium Citri Reticulatae, Rhizoma Alismatis, Cortex Moutan, Poria, Pseudobulbus Cremastrae Seu Pleiones, Rhizoma Cyperi, Herba Patriniae, Spina Gleditsiae, Retinervus Luffae Fructus, the Radix Angelicae Dahuricae, Cortex Phellodendri, Squama Manis, gumshiraz; It is characterized in that: preparation method comprises the following steps:

(1) Pericarpium Citri Reticulatae, Herba Spilanthis Acmellae, Rhizoma Cyperi, Herba Patriniae, Fructus Aurantii Immaturus were pulverized to 100 mesh sieves, and became compound standby;

(2) Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Ranunculi Ternati, Semen Coicis, Cortex Moutan, Rhizoma Alismatis, Poria, Pseudobulbus Cremastrae Seu Pleiones, Spina Gleditsiae, Retinervus Luffae Fructus, the Radix Angelicae Dahuricae, Cortex Phellodendri, Squama Manis are mixed and add 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, standing; Then toward 95% the ethanol that adds 3 ~ 4 times of medicinal liquids in decocting liquid, standing 15 minutes, then with 3000rpm/min centrifugal 20 minutes, get precipitation spraying and dry, pulverize 100 mesh sieves and obtain that just material is standby;

(3) gumshiraz was pulverized to 100 mesh sieves, and become fine powder standby;

(4) get vegetable oil and be heated to 200 ℃ ~ 220 ℃, drop into the compound that step 1 produces, stir, after 5 ~ 10 minutes, oil plant filtering;

(5) oil plant after gained filtering in step 4 is heated to 150 ℃ ~ 200 ℃, drop into lasting stirring of first material that step 2 produces, after 5 ~ 10 minutes, the gumshiraz fine powder that adds step 3 to produce while being cooled to 80 ℃ ~ 100 ℃ after oil plant filtering, continue to decoct, boil while dripping beading, surface spray cold water, remove noxious water, be cooled to room temperature to be distributed into bottle.

In preferred version, above-mentioned vegetable oil is Oleum Sesami.

Wherein said: the Radix Paeoniae Alba is the dry root of ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall..Nature and flavor are bitter, sour, are slightly cold.Return liver, spleen channel.Merit can suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.

Herba Spilanthis Acmellae is the herb of feverfew Herba Cancriniae lasiocarpae Spilanthes paniculata Wall.ex DC..Acrid in the mouth; Bitter; Slightly warm in nature; Mild toxicity.Merit can relieving cough and asthma; Detoxification and promoting urination; Reducing swelling and alleviating pain.

Radix Angelicae Sinensis is the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Nature and flavor sweet, acrid, warm.Return liver, the heart, spleen channel.Merit can be enriched blood and be invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.

Radix Ranunculi Ternati is the dried root of the little Herba Ranunculi Japonici Ranunculus of ranunculaceae plant ternatus Thunb..Nature and flavor sweet, acrid, warm.Return liver, lung meridian.Merit can eliminating stagnation, detumescence.

Fructus Aurantii Immaturus is the dry young fruit of rutaceae Citrus aurantium Linn. Citrus aurantium L. and variety or Fructus Citri sinensis Citrus sinensis Osbeck.Merit can dispelling the stagnated QI intestinal stasis relieving.Nature and flavor are bitter, pungent, sour, temperature.Return spleen, stomach warp.Merit can dispelling the stagnated QI removing food stagnancy, the loose painful abdominal mass of reducing phlegm.

The Semen Coicis Coixlacryma-jobiL.var.ma-yuen(Roman of Semen Coicis ，Wei gramineous herbaceous plant) mature seed kernel of S-tapf.Nature and flavor are sweet, light, are slightly cold.Return spleen, kidney, lung meridian.Merit can promoting diuresis to eliminate damp pathogen, spleen invigorating, eliminating impediment, removing pus and relieving carbuncle.

Pericarpium Citri Reticulatae is the dry mature skin of rutaceae orange Citrus reticulata Blanco and variety thereof.Nature and flavor are bitter, pungent, temperature.Return lung, spleen channel.Merit can regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.

Rhizoma Alismatis is the dry tuber of Notes On Alism At Aceae Rhizoma Alismatis Alisma orientalis (Sam.) Juzep..Nature and flavor are sweet, cold.Return kidney, urinary bladder channel.Merit can diuresis, clearing away damp-heat.

Cortex Moutan is the root bark of ranunculaceae peony Paeonia suffruticosa Andr..Nature and flavor are pungent, bitter, are slightly cold.Enter the heart, liver, kidney channel.Merit can clearing away heat and cooling blood, promoting blood circulation to remove blood stasis.

Poria is On Polyporaceae Poria Poriacocos(Schw.) the white part of Wolf sclerotium.Nature and flavor are sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Merit can promoting diuresis to eliminate damp pathogen, and spleen invigorating, reduces phlegm, mind tranquilizing and the heart calming.

Pseudobulbus Cremastrae Seu Pleiones is orchid Cremastra appendiculata Cremastra appendiculata (D.Don) Makino, pleione bulbocodioides Pleione bulbocodioides(Franch.) the dry pseudobulb of Rolfe or Pleione yunnanensis Pleione yunnanensis Rolfe.Nature and flavor are sweet, micro-pungent, cold.Enter liver, stomach warp.Merit can heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation.

Rhizoma Cyperi is the dry rhizome of sedge dried tuber Cyperus rotundus L..Pungent, the micro-hardship of nature and flavor, micro-sweet, flat.Return liver, spleen, tri-jiao channel.Merit can promoting QI circulation for relieving depression, menstruction regulating and pain relieving.

Herba Patriniae ，Wei Herba Patriniae section plant Hemerocallis citrina Baroni dragon bud Patrinia scabiosaefolia Fisch. ex Link., patrima villosa (bitter vegetarian) P. villosa (Thunb.) Juss., with root stock and root, all herbal medicine.Nature and flavor are pungent, bitter, are slightly cold.Enter stomach, large intestine, Liver Channel.Merit can heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, blood circulation promoting competent silt.

Spina Gleditsiae is the dry Spina jujubae of leguminous plant Fructus Gleditsia Gleditsia sinensis Lam..Nature and flavor are pungent, temperature.Return liver, stomach warp.The merit poison holding of can subsiding a swelling, evacuation of pus, parasite killing.

Retinervus Luffae Fructus is the vascular bundle of the dry mature fruit of cucurbitaceous plant Fructus Luffae Luffa cylindrica (L.) Roem..Sweet, flat.Return lung, stomach, Liver Channel.Merit can dredging collateral, invigorates blood circulation, and dispels the wind.

The Radix Angelicae Dahuricae is samphire Angelica dahurica (Fisch.ex Hoffm.) Benth. et Hook.f. or Radix angelicae dahuricae Angelica dahurica(Fisch.ex Hoffm.) Benth.et Hook.f. var.formosana(Boiss.) root of Shan et Yuan.Nature and flavor are pungent, temperature.Enter lung, stomach warp.Merit can expelling pathogenic wind from the body surface, pain relieving, detumescence and apocenosis, dampness leukorrhagia stopping.

Cortex Phellodendri, for cloud savoury herb wampee Phellodendron chinense Schneid. or Cortex Phellodendri Phellodendron amurense Rupr. remove the bark of crust.Nature and flavor are bitter, cold.Enter kidney, bladder, large intestine channel.Merit can heat clearing and damp drying, eliminating fire and detoxication, clearind deficient heat.

Squama Manis is the scute of Manidae animal Squama Manis Manis pentadactyla Linnaeus.Nature and flavor are salty, are slightly cold.Return liver, stomach warp.The merit stimulating milk secretion of can stimulating the menstrual flow, detumescence and apocenosis, expel wind to dredge collateral.

Gumshiraz is rosaceous plant Fructus Persicae Prunus persica (L.) Batsch, the resin flowing out on trunk.Nature and flavor are bitter, flat.Merit can be invigorated blood circulation, and QI invigorating is quenched the thirst.

Composition principle: ovarian cyst is the common disease of gynecological, and symptom is slight, falls ill hidden, often finds when gynecologial examination.Modern medicine is still not clear the pathogenic factor of ovarian cyst.Often ovarian cyst is attributed to more clinically to traditional Chinese medical science “ mass in the abdomen ", the category such as " mass in the abdomen "; think that pathogen is detained, blood stasis knot is poly-to be formed, therefore the pathogeny of modern most doctor to ovarian cyst; also often hold saying of the long-pending knot of blood stasis, how treatment starts with from qi depression to blood stasis or blood stasis due to renal deficiency more.But inventor's clinical experience thinks that mass in the abdomen is the swollen thing of reality, when take blood stasis knot, gather as main pathological basis; Ovarian cyst, for the swollen thing of capsule, includes liquid, surely belongs to the traditional Chinese medical science and is referred to as " expectorant ", is that body fluid stays the poly-loose life of changing.Especially moderate ovarian cyst, volume is larger, it forms reason and mostly is accumulation of phlegm retardance, in network, QI and blood is not all right, also can cause blood stasis, and " accumulation of blood is both of a specified duration, also can turn to expectorant water " (< < treatise on blood trouble > > volume five).So, because expectorant causes the stasis of blood, the long-pending stasis of blood is reduced phlegm, phlegm and blood stasis, and glue work, for suffering from, forms cyst then.< < danxi's experiential therapy > > cloud: " expectorant folder blood stasis, becomes nest capsule then ".Therefore, ovarian cyst is when belonging to said it " nest capsule " disease of the traditional Chinese medical science, and its main pathological basis is to be the accumulation of phlegm folder stasis of blood.Expectorant, the stasis of blood are pathological product, are again paathogenic factors; Both being the mark of disease, is also basis of disease, wherein especially take accumulation of phlegm as main pathological factor.Therefore its treatment, should invigorate blood circulation, eliminates the phlegm, eliminating stagnation, dredging collateral go forward side by side, and can promote the absorption of ovarian cyst.Radix Paeoniae Alba nourishing blood for regulating menstruation in the present invention's prescription, Chinese angelica blood supplementing is invigorated blood circulation, Cortex Moutan promoting blood circulation to remove blood stasis, gumshiraz activating blood circulation and supplementing qi, Herba Patriniae blood circulation promoting competent silt, above all medicines are started with from blood system; Semen Coicis, the eliminating dampness by diuresis of Poria invigorating spleen for diuresis, Pericarpium Citri Reticulatae the spleen strengthening and damp drying reduces phlegm, Rhizoma Alismatis, Cortex Phellodendri clearing away damp-heat, the Fructus Aurantii Immaturus dispelling the stagnated QI loose painful abdominal mass of reducing phlegm, the Radix Angelicae Dahuricae, the detumescence of Herba Spilanthis Acmellae dampness, above all medicines are started with from removing dampness; Pseudobulbus Cremastrae Seu Pleiones, Radix Ranunculi Ternati eliminating carbuncle eliminating stagnation, Spina Gleditsiae detumescence poison holding, to reach the merit of eliminating stagnation; Coordinate Rhizoma Cyperi promoting QI circulation for relieving depression, Retinervus Luffae Fructus dredging collateral is invigorated blood circulation, Squama Manis detumescence dredging collateral.

CHONG meridian being the blood pool, REN meridian connecting with the uterus and pregnancy, it is closely bound up with married woman's reproductive system physiological and pathological that band is superintended and directed in punching times.SHENQUE acupoint, umbilicus, has another name called Qizhong, is the cave of wanting on human body conception vessel, is arranged in the umbilicus of the parallel correspondence of MINGMEN acupoint, is congenital umbilical cord, the Qishe of the day after tomorrow.Therefore the present invention prepares ointment formulation, directly cover and be distributed in umbilicus, umbilicus leads to hundred arteries and veins, makes drug effect by local and in internal organs, Chong and Ren Meridians regulating.

And the effective ingredient difference according to medicine in ointment formulation prepared by the present invention is treated with a certain discrimination, water-soluble components be main medicine make dry soak after powder fried, and that fat-soluble composition is main direct pulverizing is fried, gumshiraz directly joins in the oil plant after filtration, increase figuration effect, this and direct fried comparing after traditional raw material pulverizing, conservation more, and farthest guaranteed drug effect.

The specific embodiment

Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.

Embodiment 1, crude drug weight proportion: 10 parts of the Radix Paeoniae Albas, 6 parts of Herba Spilanthis Acmellae, 3 parts of Radix Angelicae Sinensis, 6 parts of Radix Ranunculi Ternatis, 3 parts of Fructus Aurantii Immaturuss, 6 parts of Semen Coiciss, 6 parts of Pericarpium Citri Reticulataes, 6 parts of Rhizoma Alismatis, 6 parts of Cortex Moutans, 9 parts, Poria, 3 parts of Pseudobulbus Cremastrae Seu Pleioness, 15 parts of Rhizoma Cyperis, 15 parts of Herba Patriniae, 6 parts of Spina Gleditsiaes, 5 parts of Retinervus Luffae Fructuss, 6 parts of the Radixs Angelicae Dahuricae, 6 parts of Cortex Phellodendris, 3 parts of Squama Maniss, 10 parts of gumshiraz.

Its preparation method is:

(1) Pericarpium Citri Reticulatae, Herba Spilanthis Acmellae, Rhizoma Cyperi, Herba Patriniae, Fructus Aurantii Immaturus were pulverized to 100 mesh sieves, and became compound standby;

(2) Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Ranunculi Ternati, Semen Coicis, Cortex Moutan, Rhizoma Alismatis, Poria, Pseudobulbus Cremastrae Seu Pleiones, Spina Gleditsiae, Retinervus Luffae Fructus, the Radix Angelicae Dahuricae, Cortex Phellodendri, Squama Manis are mixed and add 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, standing; Then toward 95% the ethanol that adds 3 times of medicinal liquids in decocting liquid, standing 15 minutes, then with 3000rpm/min centrifugal 20 minutes, get precipitation spraying and dry, pulverize 100 mesh sieves and obtain that just material is standby;

(3) gumshiraz was pulverized to 100 mesh sieves, and become fine powder standby;

(4) get Oleum Brassicae campestris and be heated to 200 ℃ ℃, drop into the compound that step 1 produces, stir, after 10 minutes, oil plant filtering;

(5) oil plant after gained filtering in step 4 is heated to 150 ℃, drop into lasting stirring of first material that step 2 produces, after 10 minutes, the gumshiraz fine powder that adds step 3 to produce while being cooled to 80 ℃ after oil plant filtering, continue to decoct, boil while dripping beading, surface spray cold water, remove noxious water, be cooled to room temperature to be distributed into bottle.

Embodiment 2, crude drug weight proportion: 20 parts of the Radix Paeoniae Albas, 10 parts of Herba Spilanthis Acmellae, 6 parts of Radix Angelicae Sinensis, 10 parts of Radix Ranunculi Ternatis, 6 parts of Fructus Aurantii Immaturuss, 10 parts of Semen Coiciss, 10 parts of Pericarpium Citri Reticulataes, 10 parts of Rhizoma Alismatis, 10 parts of Cortex Moutans, 12 parts, Poria, 6 parts of Pseudobulbus Cremastrae Seu Pleioness, 20 parts of Rhizoma Cyperis, 20 parts of Herba Patriniae, 12 parts of Spina Gleditsiaes, 6 parts of Retinervus Luffae Fructuss, 10 parts of the Radixs Angelicae Dahuricae, 10 parts of Cortex Phellodendris, 6 parts of Squama Maniss, 20 parts of gumshiraz.

Its preparation method is:

(1) Pericarpium Citri Reticulatae, Herba Spilanthis Acmellae, Rhizoma Cyperi, Herba Patriniae, Fructus Aurantii Immaturus were pulverized to 100 mesh sieves, and became compound standby;

(2) Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Ranunculi Ternati, Semen Coicis, Cortex Moutan, Rhizoma Alismatis, Poria, Pseudobulbus Cremastrae Seu Pleiones, Spina Gleditsiae, Retinervus Luffae Fructus, the Radix Angelicae Dahuricae, Cortex Phellodendri, Squama Manis are mixed and add 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, standing; Then toward 95% the ethanol that adds 3 times of medicinal liquids in decocting liquid, standing 15 minutes, then with 3000rpm/min centrifugal 20 minutes, get precipitation spraying and dry, pulverize 100 mesh sieves and obtain that just material is standby;

(3) gumshiraz was pulverized to 100 mesh sieves, and become fine powder standby;

(4) get Oleum Sesami and be heated to 210 ℃, drop into the compound that step 1 produces, stir, after 8 minutes, oil plant filtering;

(5) oil plant after gained filtering in step 4 is heated to 180 ℃, drop into lasting stirring of first material that step 2 produces, after 8 minutes, the gumshiraz fine powder that adds step 3 to produce while being cooled to 90 ℃ after oil plant filtering, continue to decoct, boil while dripping beading, surface spray cold water, remove noxious water, be cooled to room temperature to be distributed into bottle.

Embodiment 3, crude drug weight proportion: 30 parts of the Radix Paeoniae Albas, 12 parts of Herba Spilanthis Acmellae, 10 parts of Radix Angelicae Sinensis, 12 parts of Radix Ranunculi Ternatis, 10 parts of Fructus Aurantii Immaturuss, 12 parts of Semen Coiciss, 12 parts of Pericarpium Citri Reticulataes, 12 parts of Rhizoma Alismatis, 12 parts of Cortex Moutans, 15 parts, Poria, 10 parts of Pseudobulbus Cremastrae Seu Pleioness, 30 parts of Rhizoma Cyperis, 30 parts of Herba Patriniae, 15 parts of Spina Gleditsiaes, 9 parts of Retinervus Luffae Fructuss, 12 parts of the Radixs Angelicae Dahuricae, 12 parts of Cortex Phellodendris, 9 parts of Squama Maniss, 25 parts of gumshiraz.

Its preparation method is:

(1) Pericarpium Citri Reticulatae, Herba Spilanthis Acmellae, Rhizoma Cyperi, Herba Patriniae, Fructus Aurantii Immaturus were pulverized to 100 mesh sieves, and became compound standby;

(2) Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Ranunculi Ternati, Semen Coicis, Cortex Moutan, Rhizoma Alismatis, Poria, Pseudobulbus Cremastrae Seu Pleiones, Spina Gleditsiae, Retinervus Luffae Fructus, the Radix Angelicae Dahuricae, Cortex Phellodendri, Squama Manis are mixed and add 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, standing; Then toward 95% the ethanol that adds 3 ~ 4 times of medicinal liquids in decocting liquid, standing 15 minutes, then with 3000rpm/min centrifugal 20 minutes, get precipitation spraying and dry, pulverize 100 mesh sieves and obtain that just material is standby;

(3) gumshiraz was pulverized to 100 mesh sieves, and become fine powder standby;

(4) get Petiolus Trachycarpi oil and be heated to 220 ℃, drop into the compound that step 1 produces, stir, after 5 minutes, oil plant filtering;

(5) oil plant after gained filtering in step 4 is heated to 200 ℃, drop into lasting stirring of first material that step 2 produces, after 5 minutes, the gumshiraz fine powder that adds step 3 to produce while being cooled to 100 ℃ after oil plant filtering, continue to decoct, boil while dripping beading, surface spray cold water, remove noxious water, be cooled to room temperature to be distributed into bottle.

Effective combination of said medicine, coordinates mutually, invigorates blood circulation, eliminates the phlegm, eliminating stagnation, dredging collateral, effectively reach the object for the treatment of ovarian cyst, and side effect is less.The above results is that clinical data fully proves, interrelated data is as follows, and wherein drugs use is crude drug weight proportion and preparation method in embodiment 2.

1 object and method.

1.1 object.

1.1.1 case selection: in March, 2008 ~ 2011 are diagnosed as ovarian cyst 89 examples year June, are outpatient, are divided into oral group and ointment group.Oral group of 48 examples, age 19 ~ 45(34.32 ± 2.71) year; The course of disease 6 months to 8 years, average (3.59 ± 1.02) year; One-sided cyst 42 examples, bilateral cyst 6 examples; Cyst diameter 32 ~ 75(50.92 ± 3.98) mm.Ointment group 41 examples, age 24 ~ 49(36.1 ± 5.21) year, the course of disease 4 months to 7 years, average (3.77 ± 1.12) year; One-sided cyst 31 examples, bilateral cyst 9 examples; Cyst diameter 29 ~ 73mm, average (51.42 ± 4.89) mm.Before two groups of patient treatments, on age, the state of an illness, the course of disease, cyst diameter, compare, difference not statistically significant (P>0.05), has comparability.

1.1.2 diagnostic criteria: with reference to < < obstetrics and gynecology > > (the 5th edition), all cases all checks and clarifies a diagnosis, and get rid of malignant tumor of ovary according to medical history, gynecologial examination, B ultrasonic or CT and radioimmunity AFP, Ca 125.

1.2 method.

1.2.1 Therapeutic Method: take capsule (crude drug weight proportion is identical with the embodiment of the present invention 2), 6g/ time, 2 times/d for oral group.Prepared ointment in the embodiment of the present invention 2 for ointment group, external is covered cloth in omphalos, external application rubber plaster, 3 times/d.Two groups of treatments are all at the 7th day begin treatment of menstruation, and stop using menstrual period.Be 1 course for the treatment of January, checks 1 time after the course for the treatment of, after 3 courses for the treatment of, adds up curative effect.Period in a medicine is refused to obey other drug.

1.2.2 criterion of therapeutical effect: with reference to < < obstetrics and gynecology > >, recovery from illness: clinical symptoms, sign disappear, B ultrasonic is detected ovarian cyst and is disappeared; Effective: clinical symptoms, sign turn for the better by and large, B ultrasonic is detected ovarian cyst and is dwindled more than 1/2, or a cysta lateralis disappears; Effective: clinical symptoms, sign alleviate, B ultrasonic is detected before ovarian cyst is treated and is dwindled less than 1/2; Invalid: clinical symptoms, sign and ultrasound diagnosis are unchanged.

1.2.3 statistical analysis SPSS 11.0 carries out statistical analysis.Measurement data is checked with t, enumeration data χ ²check.

2 results.

The comparison of 2.1 liang of group Comprehensive Clinical curative effects: oral group of compare with ointment group cure rate and total effective rate difference not statistically significant (P>0.05), see the following form.

Group

Number of cases

Cure

Effective

Effectively

Invalid

Total effective rate

Oral group

48

21（43.75%）

15（31.25%）

8（16.67%）

4（8.33%）

91.67%

Ointment group

41

16（39.02%）

16（39.02%）

4（9.76%）

5（12.20%）

87.80%

B ultrasonic ovarian cyst diameter situation of change before and after 2.2 liang of group treatments: before oral group for the treatment of, ovarian cyst diameter is (50.92 ± 3.98) mm, after treatment, be kept to (23.67 ± 2.63) mm, before and after treatment, difference has statistical significance (t=2.692, P<0.01), before the treatment of ointment group, ovarian cyst diameter is (52.32 ± 4.09) mm, after treatment, be kept to (26.11 ± 3.16) mm, before and after treatment, difference has statistical significance (t=2.571, P<0.01), after treatment, oral group reduces degree with the ovarian cyst diameter of ointment group and compares no difference of science of statistics (P>0.05).

2.3 liang of group adverse reactions of patients incidence rates comparison: oral group occurs untoward reaction totally 2 examples, and incidence rate is 4.17%, stomach discomfort 1 example wherein, 1 example of suffering from diarrhoea; Ointment group has no adverse reaction.Two group differences have statistical significance (P<0.01).

3. conclusion.

This result of study shows, the ointment therapeutic effect that preparation method of the present invention is prepared is with similar with formula oral capsule, after treatment, ovarian cyst diameter obviously reduces, effective percentage is 87.80%, and the incidence rate of untoward reaction is lower than oral group, the present invention is described, and untoward reaction is light, the higher advantage of safety having aspect treatment ovarian cyst.

Claims (3)

1. a preparation method for the treatment of ovarian cyst ointment, it is characterized in that: crude drug weight proportion: 10 parts of the Radix Paeoniae Albas, 6 parts of Herba Spilanthis Acmellae, 3 parts of Radix Angelicae Sinensis, 6 parts of Radix Ranunculi Ternatis, 3 parts of Fructus Aurantii Immaturuss, 6 parts of Semen Coiciss, 6 parts of Pericarpium Citri Reticulataes, 6 parts of Rhizoma Alismatis, 6 parts of Cortex Moutans, 9 parts, Poria, 3 parts of Pseudobulbus Cremastrae Seu Pleioness, 15 parts of Rhizoma Cyperis, 15 parts of Herba Patriniae, 6 parts of Spina Gleditsiaes, 5 parts of Retinervus Luffae Fructuss, 6 parts of the Radixs Angelicae Dahuricae, 6 parts of Cortex Phellodendris, 3 parts of Squama Maniss, 10 parts of gumshiraz; Preparation method comprises the following steps:

(1) Pericarpium Citri Reticulatae, Herba Spilanthis Acmellae, Rhizoma Cyperi, Herba Patriniae, Fructus Aurantii Immaturus were pulverized to 100 mesh sieves, and became compound standby;

(2) Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Ranunculi Ternati, Semen Coicis, Cortex Moutan, Rhizoma Alismatis, Poria, Pseudobulbus Cremastrae Seu Pleiones, Spina Gleditsiae, Retinervus Luffae Fructus, the Radix Angelicae Dahuricae, Cortex Phellodendri, Squama Manis are mixed and add 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, standing; Then toward 95% the ethanol that adds 3 ~ 4 times of medicinal liquids in decocting liquid, standing 15 minutes, then with 3000rpm centrifugal 20 minutes, get precipitation spraying and dry, pulverize 100 mesh sieves and obtain that just material is standby;

(3) gumshiraz was pulverized to 100 mesh sieves, and become fine powder standby;

(4) get Oleum Brassicae campestris and be heated to 200 ℃ ~ 220 ℃, drop into the compound that step 1 produces, stir, after 5 ~ 10 minutes, oil plant filtering;

(5) oil plant after gained filtering in step 4 is heated to 150 ℃ ~ 200 ℃, drop into lasting stirring of first material that step 2 produces, after 5 ~ 10 minutes, the gumshiraz fine powder that adds step 3 to produce while being cooled to 80 ℃ ~ 100 ℃ after oil plant filtering, continue to decoct, boil while dripping beading, surface spray cold water, remove noxious water, be cooled to room temperature to be distributed into bottle.

2. a preparation method for the treatment of ovarian cyst ointment, is characterized in that: crude drug weight proportion: 20 parts of the Radix Paeoniae Albas, 10 parts of Herba Spilanthis Acmellae, 6 parts of Radix Angelicae Sinensis, 10 parts of Radix Ranunculi Ternatis, 6 parts of Fructus Aurantii Immaturuss, 10 parts of Semen Coiciss, 10 parts of Pericarpium Citri Reticulataes, 10 parts of Rhizoma Alismatis, 10 parts of Cortex Moutans, 12 parts, Poria, 6 parts of Pseudobulbus Cremastrae Seu Pleioness, 20 parts of Rhizoma Cyperis, 20 parts of Herba Patriniae, 12 parts of Spina Gleditsiaes, 6 parts of Retinervus Luffae Fructuss, 10 parts of the Radixs Angelicae Dahuricae, 10 parts of Cortex Phellodendris, 6 parts of Squama Maniss, 20 parts of gumshiraz; Preparation method comprises the following steps:

(1) Pericarpium Citri Reticulatae, Herba Spilanthis Acmellae, Rhizoma Cyperi, Herba Patriniae, Fructus Aurantii Immaturus were pulverized to 100 mesh sieves, and became compound standby;

(2) Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Ranunculi Ternati, Semen Coicis, Cortex Moutan, Rhizoma Alismatis, Poria, Pseudobulbus Cremastrae Seu Pleiones, Spina Gleditsiae, Retinervus Luffae Fructus, the Radix Angelicae Dahuricae, Cortex Phellodendri, Squama Manis are mixed and add 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, standing; Then toward 95% the ethanol that adds 3 ~ 4 times of medicinal liquids in decocting liquid, standing 15 minutes, then with 3000rpm centrifugal 20 minutes, get precipitation spraying and dry, pulverize 100 mesh sieves and obtain that just material is standby;

(3) gumshiraz was pulverized to 100 mesh sieves, and become fine powder standby;

(4) get Oleum Sesami and be heated to 200 ℃ ~ 220 ℃, drop into the compound that step 1 produces, stir, after 5 ~ 10 minutes, oil plant filtering;

(5) oil plant after gained filtering in step 4 is heated to 150 ℃ ~ 200 ℃, drop into lasting stirring of first material that step 2 produces, after 5 ~ 10 minutes, the gumshiraz fine powder that adds step 3 to produce while being cooled to 80 ℃ ~ 100 ℃ after oil plant filtering, continue to decoct, boil while dripping beading, surface spray cold water, remove noxious water, be cooled to room temperature to be distributed into bottle.

3. a preparation method for the treatment of ovarian cyst ointment, it is characterized in that: crude drug weight proportion: 30 parts of the Radix Paeoniae Albas, 12 parts of Herba Spilanthis Acmellae, 10 parts of Radix Angelicae Sinensis, 12 parts of Radix Ranunculi Ternatis, 10 parts of Fructus Aurantii Immaturuss, 12 parts of Semen Coiciss, 12 parts of Pericarpium Citri Reticulataes, 12 parts of Rhizoma Alismatis, 12 parts of Cortex Moutans, 15 parts, Poria, 10 parts of Pseudobulbus Cremastrae Seu Pleioness, 30 parts of Rhizoma Cyperis, 30 parts of Herba Patriniae, 15 parts of Spina Gleditsiaes, 9 parts of Retinervus Luffae Fructuss, 12 parts of the Radixs Angelicae Dahuricae, 12 parts of Cortex Phellodendris, 9 parts of Squama Maniss, 25 parts of gumshiraz; Preparation method comprises the following steps:

(1) Pericarpium Citri Reticulatae, Herba Spilanthis Acmellae, Rhizoma Cyperi, Herba Patriniae, Fructus Aurantii Immaturus were pulverized to 100 mesh sieves, and became compound standby;

(2) Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Ranunculi Ternati, Semen Coicis, Cortex Moutan, Rhizoma Alismatis, Poria, Pseudobulbus Cremastrae Seu Pleiones, Spina Gleditsiae, Retinervus Luffae Fructus, the Radix Angelicae Dahuricae, Cortex Phellodendri, Squama Manis are mixed and add 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, standing; Then toward 95% the ethanol that adds 3 ~ 4 times of medicinal liquids in decocting liquid, standing 15 minutes, then with 3000rpm centrifugal 20 minutes, get precipitation spraying and dry, pulverize 100 mesh sieves and obtain that just material is standby;

(3) gumshiraz was pulverized to 100 mesh sieves, and become fine powder standby;

(4) get Petiolus Trachycarpi oil and be heated to 200 ℃ ~ 220 ℃, drop into the compound that step 1 produces, stir, after 5 ~ 10 minutes, oil plant filtering;

(5) oil plant after gained filtering in step 4 is heated to 150 ℃ ~ 200 ℃, drop into lasting stirring of first material that step 2 produces, after 5 ~ 10 minutes, the gumshiraz fine powder that adds step 3 to produce while being cooled to 80 ℃ ~ 100 ℃ after oil plant filtering, continue to decoct, boil while dripping beading, surface spray cold water, remove noxious water, be cooled to room temperature to be distributed into bottle.