CN103432490B - Traditional Chinese medicine composition for treating cough - Google Patents

Abstract

The invention relates to a traditional Chinese medicine composition for treating a cough. The traditional Chinese medicine composition comprises the following crude drugs in parts by weight: 17 parts of lilium brownii, 14 parts of cordate houttuynia, 15 parts of peach kernels, 17 parts of liquorice, 16 parts of fructus forsythiae, 12 parts of apricot kernels, 14 parts of indian buead, 9 parts of dwarf lilyturf turber, 13 parts of adenophora stricta, 14 parts of rhizoma anemarrhenae, 11 parts of platycladi seeds, 13 parts of fritillary, 17 parts of platycodon grandiflorum, 10 parts of scutellaria baicalensis, 15 parts of mint, 14 parts of radix stemonae, 16 parts of honeysuckle, 3 parts of angelica, 14 parts of fructus crataegi and 5 parts of semen plantaginis.

Description

The Chinese medicine composition for the treatment of cough

Technical field

The present invention relates to a kind of Chinese medicine composition for the treatment of cough.

Background technology

One of main syndromes of lung system illness is exactly cough.Throughout history, ancient Chinese medicine doctor has different opinion for cough.Huangdi's Internal Classics proposes the demonstration of " vital organs of the human body all make us coughing, and non-only lung also " ".Jing-Yue Complete Works is discussed again " cough one card, be surreptitiously seen in family set forth one's views numerous greatly, neither its want, cause more descendant face card Mo Zhisuo from, so control rare effect ".Cough is demonstrate,proved by being divided into diseases caused by exogenous pathogenic factor, internal injury two class by Zhang Jingyue.Mention again in " the interchannel six scripts " " cold and summer-heat dampness wind-fire six gas, all makes us coughing ".Cough is disease and syndrome, and any age all can fall ill, and winter-spring season is common.The cause of disease of cough has diseases caused by exogenous pathogenic factor, internal injury not, the cough that wind, cold, summer-heat, wet, dry, fiery six climate exopathogens heresy invasion and attack lung system cause, for exogenous cough, in exopathogen again with wind, cold, heat cough is in the majority, and Chang Yifeng is first number, hold under the arm cold or hold heat under the arm, hold dry criminal's lung under the arm, wind and cold or the cough such as wind heat, wind-dryness occur; Due to the cough that lungs virtual loss and other visceral dysfunctions have influence on lung and cause, be endogenous cough.Normal internal injury, exogenous cough's cross-reference reciprocal causation clinically.Said as " cough of medical science innermost thoughts and feelings ": " lung body belongs to gold, kowtows do not ring such as Zhong Ran, Zhong Fei, and the heresy of wind and cold heat-damp in summer dryness-fire six climate exopathogens is from then ringing of hitting outward, and labor is for feelings will, and fire then also the ringing from inside fire attack of Bo processed by diet ".

Cough is guiding principle with differential diagnosis in terms of eight principles, and head distinguishes diseases caused by exogenous pathogenic factor and internal injury, common with exogenous cough, sends out lung qi for basic principle to declare.Children's exogenous cough is divided into wind and cold and the large pattern of syndrome of wind heat two by Wang Shouchuan, and Han new people are divided into the large pattern of syndrome of wind and cold, wind heat and wind-dryness three, and wherein cough due to wind and cold is with expelling wind and cold, lung qi dispersing cough-relieving for method for the treatment of, adds and subtracts with jinfeicao powder; Cough due to pathogenic wind-heat, adds and subtracts with SANGJU YIN for method for the treatment of with dispelling wind and heat pathogens, lung qi dispersing cough-relieving; Wind-dryness cough, is added and subtracted with Decoction for Reliving Dryness of the Lung for method for the treatment of with dispelling wind lung heat clearing, nourishing the lung to arrest cough.Zhong Hua etc. then distinguish control exogenous cough according to child physical endowment, are divided into four types and normal matter youngster, phlegm-damp matter youngster, deficiency of vital energy matter youngster and deficiency of YIN matter youngster, normal matter youngster to evacuate exopathogen, lung qi dispersing cough-relieving for method for the treatment of, with Apricot Kernel and Perilla Powder, SANGJU YIN and numb Fructus Pruni Shigao Tang etc. for main formula; Phlegm-damp matter youngster with the spleen strengthening and damp drying, preventing phlegm from forming and stopping coughing for method for the treatment of, with numb Fructus Pruni ERCHEN TANG for main formula; Deficiency of vital energy matter youngster with dispelling wind and ventilating the lung, preventing phlegm from forming and stopping coughing, assistant with invigorating the spleen and benefiting QI for method for the treatment of, the basic side of wind and cold or wind heat takes the circumstances into consideration to add with the resistance and supplementing qi medicine such as the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, or Liujunzi Tang adds Rhizoma Belamcandae, Herba Houttuyniae, Fructus Forsythiae, Radix Platycodonis etc.

CN102078558A discloses a kind of pharmaceutical composition for the treatment of cough, and wherein the weight proportion of crude drug is as follows: Ramulus Uncariae Cum Uncis 30 parts, Concretio Silicea Bambusae 40 parts, Radix Platycodonis 10 parts; Fructus Amomi 50 parts, Pericarpium Citri Reticulatae 50 parts, 10 parts, Poria; Herba Menthae 50 parts, 20 parts, Radix Glycyrrhizae, Calculus Bovis 7 parts.

CN101991802A discloses a kind of Chinese medicine preparation for the treatment of cold cough, it contains Flos Lonicerae 30 parts, Pericarpium Citri Reticulatae 30 parts, Herba Artemisiae Scopariae 25 parts, the Radix Stemonae 35 parts, 30 parts, Radix Glycyrrhizae, Semen Armeniacae Amarum 25 parts, Semen Platycladi 25 parts, Bulbus Fritillariae Uninbracteatae 20 parts, Radix Platycodonis 30 parts, 20 parts, Fructus Jujubae, 15 parts, dry moxa leaf and appropriate Mel.

Summary of the invention

The invention provides a kind of Chinese medicine composition being used for the treatment of cough, wherein the weight proportion of crude drug is as follows:

Bulbus Lilii 17 parts, Herba Houttuyniae 14 parts, 15 parts, Semen Persicae, 17 parts, Radix Glycyrrhizae, Fructus Forsythiae 16 parts, 12 parts, Semen Armeniacae Amarum, 14 parts, Poria, Radix Ophiopogonis 9 parts, Radix Adenophorae (Radix Glehniae) 13 parts, the Rhizoma Anemarrhenae 14 parts, Semen Platycladi 11 parts, Bulbus Fritillariae Uninbracteatae 13 parts, Radix Platycodonis 17 parts, Radix Scutellariae 10 parts, Herba Menthae 15 parts, the Radix Stemonae 14 parts, Flos Lonicerae 16 parts, Radix Angelicae Sinensis 3 parts, Fructus Crataegi 14 parts, Semen Plantaginis 5 parts.

Preparation method, for getting above crude drug, puts into container, adds cold water and covers powder, soaks 15 ~ 20 minutes, then adds water and do not have powder about 8 centimetres, decocts.Intense fire is adopted to decoct at a simmer, with slow fire boiling 20 ~ 30 minutes after boiling; Second time decocts, slow fire boiling 15 ~ 20 minutes after water boils.Twice decoction is removed slag extracting juice, merges.

Detailed description of the invention

Embodiment 1

Bulbus Lilii 17 parts, Herba Houttuyniae 14 parts, 15 parts, Semen Persicae, 17 parts, Radix Glycyrrhizae, Fructus Forsythiae 16 parts, 12 parts, Semen Armeniacae Amarum, 14 parts, Poria, Radix Ophiopogonis 9 parts, Radix Adenophorae (Radix Glehniae) 13 parts, the Rhizoma Anemarrhenae 14 parts, Semen Platycladi 11 parts, Bulbus Fritillariae Uninbracteatae 13 parts, Radix Platycodonis 17 parts, Radix Scutellariae 10 parts, Herba Menthae 15 parts, the Radix Stemonae 14 parts, Flos Lonicerae 16 parts, Radix Angelicae Sinensis 3 parts, Fructus Crataegi 14 parts, Semen Plantaginis 5 parts

Preparation method, for getting above crude drug, puts into container, adds cold water and covers powder, soaks 15 ~ 20 minutes, then adds water and do not have powder about 8 centimetres, decocts.Intense fire is adopted to decoct at a simmer, with slow fire boiling 20 ~ 30 minutes after boiling; Second time decocts, slow fire boiling 15 ~ 20 minutes after water boils.Twice decoction is removed slag extracting juice, merges.

Reference substance 1

The pharmaceutical composition of the disclosed treatment cough of CN102078558A, wherein the weight proportion of crude drug is as follows: Ramulus Uncariae Cum Uncis 30 parts, Concretio Silicea Bambusae 40 parts, Radix Platycodonis 10 parts; Fructus Amomi 50 parts, Pericarpium Citri Reticulatae 50 parts, 10 parts, Poria; Herba Menthae 50 parts, 20 parts, Radix Glycyrrhizae, Calculus Bovis 7 parts.

Reference substance 2

The Chinese medicine preparation of CN101991802A disclosed treatment cold cough, it contains Flos Lonicerae 30 parts, Pericarpium Citri Reticulatae 30 parts, Herba Artemisiae Scopariae 25 parts, the Radix Stemonae 35 parts, 30 parts, Radix Glycyrrhizae, Semen Armeniacae Amarum 25 parts, Semen Platycladi 25 parts, Bulbus Fritillariae Uninbracteatae 20 parts, Radix Platycodonis 30 parts, 20 parts, Fructus Jujubae, 15 parts, dry moxa leaf and appropriate Mel.

Experimental example 2: antitussive effect sulfur dioxide smog being caused to mouse cough model

The mice of 18-22 g is divided into 5 groups at random, model control group gives gavage normal saline, tested group gives each 2.0 g/kg of drug sample described in gavage embodiment 1 and reference substance 1,2, positive controls gives Fructus Chebulae's soup extract 2.0 g/kg, gavage volume is about 1 ml/100 g, successive administration 5 days.After last administration 30 minutes, mice is put in closed glass case, the smog induction quantitatively spraying into sulfur burning generation causes to be coughed, record in mouse cough incubation period and 3 minutes number of times of coughing, result tested group of embodiment 1 and the average cough latent period of positive drug control group all extend more than 30 seconds, average cough number of times obviously reduces, tested group of average cough latent period of reference substance 1,2 all extend more than 10 seconds, average cough number of times is more, show that drug sample of the present invention has obvious antitussive effect, be better than Fructus Chebulae's sweet Fructus Citri tangerinae soup extract and reference substance 1,2.Experimental result is as shown in table 1.

Table 1 drug sample of the present invention to sulfur dioxide smog cause mouse cough antitussive effect ( ± S, n=15)

Note: compare with model group, * p<0.05, * * p<0.01

Embodiment 3 clinical therapeutic efficacy:

Criterion of therapeutical effect: Outcome measure Main Basis is whether cough symptom disappears.Medication 15 days is 1 course for the treatment of.Concrete curative effect divides following three grades: cure---and cough symptom all disappears; Taking a turn for the better---cough symptom obviously alleviates; Invalid---after 1 course for the treatment of of medication, cough symptom has no to disappear.

Effect: by Drug therapy cough patients 44 example of the present invention, treat 1 course for the treatment of, wherein cure 43 examples, take a turn for the better 1 example, and cure rate is 97.7%, and effective percentage is 100%.

Model case:

Grandson, female, 67 years old, peasant.In November, 2006 goes to a doctor.Patient's readme, criminal's cough is existing has a surplus on the 10th.Symptom cough is breathed hard, and cough up phlegm sticky yellow, pharyngalgia, micro evil wind is trembled with fear.White and thin fur, red tip of the tongue, floating and rapid pulse.Adopt medicine of the present invention, first take 10 days, symptom is clearly better, and follow-uply takes 5 days, recovery from illness.Within 2 months, visit, have no recurrence.

Claims (1)

1. be used for the treatment of a Chinese medicine composition for cough, wherein the weight proportion of crude drug is as follows:

Bulbus Lilii 17 parts, Herba Houttuyniae 14 parts, 15 parts, Semen Persicae, 17 parts, Radix Glycyrrhizae, Fructus Forsythiae 16 parts, 12 parts, Semen Armeniacae Amarum, 14 parts, Poria, Radix Ophiopogonis 9 parts, Radix Adenophorae (Radix Glehniae) 13 parts, the Rhizoma Anemarrhenae 14 parts, Semen Platycladi 11 parts, Bulbus Fritillariae Uninbracteatae 13 parts, Radix Platycodonis 17 parts, Radix Scutellariae 10 parts, Herba Menthae 15 parts, the Radix Stemonae 14 parts, Flos Lonicerae 16 parts, Radix Angelicae Sinensis 3 parts, Fructus Crataegi 14 parts, Semen Plantaginis 5 parts.