CN103394020B - Composition used for treating cough - Google Patents

Abstract

The invention relates to a composition used for treating cough. The composition comprises following raw materials, by weight, 16 portions of licorice, 15 portions of fructus forsythia, 13 portions of cassia twig, 14 portions of radix ophiopogonis, 12 portions of straight ladybell, 15 portions of dried orange peel, 15 portions of mangnolia officinalis, 13 portions of semen boitae, 11 portions of fritillary, 17 portions of platycodon grandiflorum, 10 portions of epimedium, 15 portions of fructus amomi, 21 portions of wolfberry, 13 portions of flos farfarae, 18 portions of mint, 18 portions of radix stemonae, 15 portions of Lonicera japonica, 16 portions of angelica sinensis and 14 portions of radix angelicae.

Description

The compositions for the treatment of cough

Technical field

The present invention relates to a kind of Chinese medicine composition for the treatment of cough.

Background technology

Lung is that one of main syndromes of illness is exactly cough.Throughout history, ancient Chinese medicine doctor has different opinion for cough.< < Huang di's Canon of Medicine > > proposes the demonstration of " vital organs of the human body all make us coughing, and non-only lung also " ".< < Jing Yue's complete work > > discuss again " cough one card, be surreptitiously seen in family set forth one's views numerous greatly, neither it is wanted, cause more descendant face card Mo Zhisuo from, so control rare effect ".Zhang Jingyue demonstrate,proves cough by being divided into diseases caused by exogenous pathogenic factor, internal injury two classes.In < < interchannel six scripts > >, mention again " cold and summer-heat dampness wind-fire six gas, all make us coughing ".Cough is disease and syndrome, and any age all can fall ill, and winter-spring season is common.The cause of disease of cough has diseases caused by exogenous pathogenic factor, internal injury not, it is the cough causing that heresy of wind, cold, summer-heat, wet, dry, fiery six climate exopathogens attacked lung, for exogenous cough, in exopathogen again with wind, cold, heat cough is in the majority, and Chang Yifeng is first number, hold under the arm cold or hold heat under the arm, hold dry criminal's lung under the arm, the coughs such as wind and cold or wind heat, wind-dryness occur; Because lungs virtual loss and other visceral dysfunctions have influence on the cough that lung causes, be endogenous cough.Normal internal injury, exogenous cough's cross-reference reciprocal causation clinically.Said as < < medical science innermost thoughts and feelings cough > >: " lung body belongs to gold; such as Zhong Ran; Zhong Fei kowtows and do not ring; the heresy of wind and cold heat-damp in summer dryness-fire six climate exopathogens is from the ring of hitting outward; labor is wanted feelings will, and diet is processed the fire of Bo from the also ring of inside fire attack ".

Cough be take differential diagnosis in terms of eight principles as guiding principle, and head distinguishes diseases caused by exogenous pathogenic factor and internal injury, common with exogenous cough, take to declare that to send out a lung qi be basic principle.Wang Shouchuan is divided into wind and cold and the large pattern of syndrome of wind heat two by children's exogenous cough, and Han new people are divided into wind and cold, wind heat and the large pattern of syndrome of wind-dryness three, wherein cough due to wind and cold to take expelling wind and cold, lung qi dispersing cough-relieving be method for the treatment of, with jinfeicao powder, add and subtract; It is method for the treatment of that cough due to pathogenic wind-heat be take dispelling wind and heat pathogens, lung qi dispersing cough-relieving, with SANGJU YIN, adds and subtracts; It is method for the treatment of that dispelling wind lung heat clearing, nourishing the lung to arrest cough are take in wind-dryness cough, with Decoction for Reliving Dryness of the Lung, adds and subtracts.Zhong Hua etc. distinguish and control exogenous cough according to children's's body constitution, and being divided into four types is normal matter youngster, phlegm-damp matter youngster, deficiency of vital energy matter youngster and deficiency of YIN matter youngster, normal matter youngster take evacuate exopathogen, lung qi dispersing cough-relieving is method for the treatment of, take Apricot Kernel and Perilla Powder, SANGJU YIN and numb Fructus Pruni Shigao Tang etc. is main formula; It is method for the treatment of that phlegm-damp matter youngster be take the spleen strengthening and damp drying, preventing phlegm from forming and stopping coughing, and the numb Fructus Pruni ERCHEN TANG of take is main formula; Deficiency of vital energy matter youngster be take invigorating the spleen and benefiting QI as method for the treatment of with dispelling wind and ventilating the lung, preventing phlegm from forming and stopping coughing, assistant, take the circumstances into consideration to add with resistance and supplementing qi medicines such as the Rhizoma Atractylodis Macrocephalae, the Radixs Astragali, or Liujunzi Tang adds Rhizoma Belamcandae, Herba Houttuyniae, Fructus Forsythiae, Radix Platycodonis etc. in wind and cold or the basic side of wind heat.

CN102078558A discloses a kind of pharmaceutical composition for the treatment of cough, and wherein the weight proportion of crude drug is as follows: 30 parts of Ramulus Uncariae Cum Uncis, 40 parts of Concretio Silicea Bambusaes, 10 parts of Radix Platycodoniss; 50 parts of Fructus Amomis, 50 parts of Pericarpium Citri Reticulataes, 10 parts, Poria; 50 parts of Herba Menthaes, 20 parts, Radix Glycyrrhizae, 7 parts of Calculus Boviss.

CN101991802A discloses a kind of Chinese medicine preparation for the treatment of cold cough, it contains 30 parts of Flos Loniceraes, 30 parts of Pericarpium Citri Reticulataes, 25 parts of Herba Artemisiae Scopariaes, 35 parts of the Radixs Stemonae, 30 parts, Radix Glycyrrhizae, 25 parts of Semen Armeniacae Amarums, 25 parts of Semen Platycladi, 20 parts of Bulbus Fritillariae Uninbracteataes, 30 parts of Radix Platycodoniss, 20 parts, Fructus Jujubae, 15 parts, dry moxa leaf and appropriate Mel.

Summary of the invention

The invention provides a kind of Chinese medicine composition that is used for the treatment of cough, wherein the weight proportion of crude drug is as follows:

16 parts, Radix Glycyrrhizae, 15 parts of Fructus Forsythiaes, 13 parts of Ramulus Cinnamomi, 14 parts of Radix Ophiopogonis, 12 parts of Radix Adenophorae (Radix Glehniae), 15 parts of Pericarpium Citri Reticulataes, 15 parts of Cortex Magnoliae Officinalis, 13 parts of Semen Platycladi, 11 parts of Bulbus Fritillariae Uninbracteataes, 17 parts of Radix Platycodoniss, 10 parts of Herba Epimedii, 15 parts of Fructus Amomis, 21 parts of Fructus Lyciis, 13 parts of Flos Farfaraees, 18 parts of Herba Menthaes, 18 parts of the Radixs Stemonae, 15 parts of Flos Loniceraes, 16 parts of Radix Angelicae Sinensis, 14 parts of the Radixs Angelicae Dahuricae.

Preparation method, for getting above crude drug, is put into container, adds cold water and covers powder, soaks 15～20 minutes, then adds water and do not have approximately 8 centimetres of powder, decocts.At a simmer, adopt intense fire to decoct, after boiling, use slow fire boiling 20～30 minutes; Decoct for the second time, after water boils, slow fire boiling is 15～20 minutes.Twice decoction extracting juice that removes slag, merges.

The specific embodiment

Embodiment 1

16 parts, Radix Glycyrrhizae, 15 parts of Fructus Forsythiaes, 13 parts of Ramulus Cinnamomi, 14 parts of Radix Ophiopogonis, 12 parts of Radix Adenophorae (Radix Glehniae), 15 parts of Pericarpium Citri Reticulataes, 15 parts of Cortex Magnoliae Officinalis, 13 parts of Semen Platycladi, 11 parts of Bulbus Fritillariae Uninbracteataes, 17 parts of Radix Platycodoniss, 10 parts of Herba Epimedii, 15 parts of Fructus Amomis, 21 parts of Fructus Lyciis, 13 parts of Flos Farfaraees, 18 parts of Herba Menthaes, 18 parts of the Radixs Stemonae, 15 parts of Flos Loniceraes, 16 parts of Radix Angelicae Sinensis, 14 parts of the Radixs Angelicae Dahuricae.

Preparation method, for getting above crude drug, is put into container, adds cold water and covers powder, soaks 15～20 minutes, then adds water and do not have approximately 8 centimetres of powder, decocts.At a simmer, adopt intense fire to decoct, after boiling, use slow fire boiling 20～30 minutes; Decoct for the second time, after water boils, slow fire boiling is 15～20 minutes.Twice decoction extracting juice that removes slag, merges.

Reference substance 1

The pharmaceutical composition of the disclosed treatment cough of CN102078558A, wherein the weight proportion of crude drug is as follows: 30 parts of Ramulus Uncariae Cum Uncis, 40 parts of Concretio Silicea Bambusaes, 10 parts of Radix Platycodoniss; 50 parts of Fructus Amomis, 50 parts of Pericarpium Citri Reticulataes, 10 parts, Poria; 50 parts of Herba Menthaes, 20 parts, Radix Glycyrrhizae, 7 parts of Calculus Boviss.

Reference substance 2

The Chinese medicine preparation of the disclosed treatment cold cough of CN101991802A, it contains 30 parts of Flos Loniceraes, 30 parts of Pericarpium Citri Reticulataes, 25 parts of Herba Artemisiae Scopariaes, 35 parts of the Radixs Stemonae, 30 parts, Radix Glycyrrhizae, 25 parts of Semen Armeniacae Amarums, 25 parts of Semen Platycladi, 20 parts of Bulbus Fritillariae Uninbracteataes, 30 parts of Radix Platycodoniss, 20 parts, Fructus Jujubae, 15 parts, dry moxa leaf and appropriate Mel.

Experimental example 2: the antitussive effect that sulfur dioxide smog is caused to mouse cough model

The mice of 18-22 g is divided into 5 groups at random, model control group gives gavage normal saline, tested group gives each 2.0 g/kg of drug sample described in gavage embodiment 1 and reference substance 1,2, positive controls gives Fructus Chebulae's soup extract 2.0 g/kg, gavage volume is about 1 ml/100 g, successive administration 5 days.After last administration 30 minutes, mice is put in airtight glass box, the smog induction that quantitatively sprays into sulfur burning generation causes to be coughed, record the number of times of coughing in mouse cough incubation period and 3 minutes, tested group of embodiment 1 of result and the average cough latent period of positive drug control group all extend 35 seconds above, the number of times of on average coughing obviously reduces, tested group of average cough latent period of reference substance 1,2 all extends that 10 seconds above, on average the number of times of coughing is more, show that drug sample of the present invention has obvious antitussive effect, be better than Fructus Chebulae's sweet Fructus Citri tangerinae soup extract and reference substance 1,2.Experimental result is as shown in table 1.

Table 1 drug sample of the present invention to sulfur dioxide smog cause mouse cough antitussive effect ( ± S, n=15)

Note: with model group comparison, * p<0.05, * * p<0.01

Embodiment 3 clinical therapeutic efficacies:

Criterion of therapeutical effect: curative effect judges Main Basis is whether cough symptom disappears.Medication 15 days is 1 course for the treatment of.Concrete curative effect is divided following three grades: cure---and cough symptom all disappears; Taking a turn for the better---cough symptom obviously alleviates; Invalid---after 1 course for the treatment of of medication, cough symptom has no to disappear.

Effect: by Drug therapy cough patient of the present invention 44 examples, treat 1 course for the treatment of, wherein cure 42 examples, 2 examples that take a turn for the better, cure rate is 95%, effective percentage is 100%.

Model case:

Zhao, man, 58 years old, peasant.In November, 2006 is medical.Patient's readme, criminal's cough is existing has a surplus on the 10th.Symptom cough is breathed hard, coughs up phlegm sticky yellow, and pharyngalgia, micro evil wind is cold.White and thin fur, red tip of the tongue, floating and rapid pulse.Adopt medicine of the present invention, first take 10 days, symptom is clearly better, and follow-uply takes 5 days, recovery from illness.Within 2 months, visit, have no recurrence.

Claims (1)

1. a Chinese medicine composition that is used for the treatment of cough, wherein the weight proportion of crude drug is as follows:

16 parts, Radix Glycyrrhizae, 15 parts of Fructus Forsythiaes, 13 parts of Ramulus Cinnamomi, 14 parts of Radix Ophiopogonis, 12 parts of Radix Adenophorae (Radix Glehniae), 15 parts of Pericarpium Citri Reticulataes, 15 parts of Cortex Magnoliae Officinalis, 13 parts of Semen Platycladi, 11 parts of Bulbus Fritillariae Uninbracteataes, 17 parts of Radix Platycodoniss, 10 parts of Herba Epimedii, 15 parts of Fructus Amomis, 21 parts of Fructus Lyciis, 13 parts of Flos Farfaraees, 18 parts of Herba Menthaes, 18 parts of the Radixs Stemonae, 15 parts of Flos Loniceraes, 16 parts of Radix Angelicae Sinensis, 14 parts of the Radixs Angelicae Dahuricae.