CN103418033B - Medical catheter hydrophilia coating liquid and preparation and application method thereof - Google Patents
Medical catheter hydrophilia coating liquid and preparation and application method thereof Download PDFInfo
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Abstract
The invention provides medical catheter hydrophilia coating liquid and preparation method. The medical catheter hydrophilia coating liquid is made of raw materials comprising, by weight percentage, 1-10% of hydrophilic polymer, 0.1-5% of polysaccharide polymer, 2-4% of hydroxypropyl-beta-cyclodextrins, 1-3% of beet red, 2-4% of hydroxypropyl methyl cellulose, 1-3% of silk fibroin, 0.2-1% of poloxamer, 0.5-1% of epsilon-polylysine and the balance water. The preparation method includes stirring and blending. The application method includes soaking, drying and baking. The application of the medical catheter hydrophilia coating liquid is simple and convenient, a medical catheter which is soaked in the coating liquid is more uniform than that sprayed, and lubricating property of the medical catheter is guaranteed during use.
Description
Technical field
The present invention relates to the coating of medical apparatus and instruments, is a kind of medical catheter hydrophilic coating liquid and preparation method thereof.
Background technology
The material of medical catheter mainly contains polyurethane, silicone rubber, latex, PVC etc., itself does not possess lubricating function these materials, the larger frictional force producing with body cavities in inserting human body process, not only use operation inconvenience, return patient and bring misery, serious damage tract wall, causes inflammation.In order to facilitate doctor to operate and to reduce patient suffering, at catheter surface, smear one deck hydrophilic lubrication coating.Coating solution is of a great variety: such as a kind of hydrophilic coating liquid that comprises isocyanates, polyvalent alcohol, PVP etc., the solvent of coating solution is the volatile organic solvents such as dichloromethane, resting period is short, temperature sharply increases higher than volatile quantity under the environment of 30 ℃, environment for use requires harsh, uses inconvenient; The solvent of coating solution generally adopts the organic solvent that meltage is high, and organic solvent has certain corrosivity to medical catheter, affects the service life of conduit, and organic solvent price is high, increases the cost of manufacture of coating solution; By support polymer and the crosslinked hydrophilic coating liquid forming of hydrophilic polymer, this medical catheter that scribbles this coating solution is after meeting water lubrication, and the maintenance lubricant effect time is 24h only, cannot meet the demand of the medical catheter of long-time use; Before use, need medical catheter to shine etc. and to carry out pretreatment by ozone, particle splash or ultraviolet light doctor, use step complicated, use inconvenience.Coating solution there will be and smears inhomogeneous phenomenon while using, and causes the part of medical catheter there is no lubricant effect, lubricated partly because frictional force causes suffering to patient more greatly.For auxiliary treatment, in coating solution, can add relevant medicine, but medicine is very fast at affected part rate of release, therapeutic effect is undesirable.
Summary of the invention
The object of the invention is, in order to overcome above-mentioned shortcoming, provides a kind of medical catheter hydrophilic coating liquid and preparation method thereof.
The present invention for achieving the above object, be achieved through the following technical solutions: a kind of medical catheter hydrophilic coating liquid, raw material by following weight percentage ratio forms: hydrophilic polymer 1-10%, polysaccharide polymer 0.1-5%, HP-β-CD 2-4%, beet red 1-3%, hydroxypropyl emthylcellulose 2-4%, fibroin albumen 1-3%, poloxamer 0.2-1%, ε-poly-D-lysine 0.5-1%, surplus is water.
Described hydrophilic polymer is polyvinyl pyrrolidone, Polyethylene Glycol or polyoxyethylene.
Described polysaccharide polymer is chitosan, carboxymethyl chitosan, carboxylic propyl group chitosan or heparin.
Described a kind of medical catheter hydrophilic coating liquid, raw material by following weight percentage ratio forms: polyvinyl pyrrolidone 10%, chitosan 3%, HP-β-CD 2%, beet red 3%, hydroxypropyl emthylcellulose 4%, fibroin albumen 1%, poloxamer 0.8%, ε-poly-D-lysine 0.5%, surplus is water.
Described a kind of medical catheter hydrophilic coating liquid, raw material by following weight percentage ratio forms: Polyethylene Glycol 5%, carboxymethyl chitosan 0.1%, HP-β-CD 3%, beet red 2%, hydroxypropyl emthylcellulose 3%, fibroin albumen 2%, poloxamer 0.2%, ε-poly-D-lysine 1%, surplus is water.
Described a kind of medical catheter hydrophilic coating liquid, raw material by following weight percentage ratio forms: polyoxyethylene 1%, carboxylic propyl group chitosan 5%, HP-β-CD 4%, beet red 1%, hydroxypropyl emthylcellulose 2%, fibroin albumen 3%, poloxamer 1%, ε-poly-D-lysine 0.7%, surplus is water.
A kind of preparation method of medical catheter hydrophilic coating liquid: comprise the steps:
1. according to following weight percentage ratio, prepare raw material: hydrophilic polymer 1-10%, polysaccharide polymer 0.1-5%, HP-β-CD 2-4%, beet red 1-3%, hydroxypropyl emthylcellulose 2-4%, fibroin albumen 1-3%, poloxamer 0.2-1%, ε-poly-D-lysine 0.5-1%, surplus is water;
2. get hydrophilic polymer and water and mix according to weight ratio 1:3-5, after mixing, stir 1-2h, speed of agitator is 30-60rpm, standingly after stirring disappears completely to bubble, obtains hydrophilic polymer aqueous solution standby;
3. get polysaccharide polymer and water and mix according to weight ratio 1:3-5, after mixing, stir 1-2h, speed of agitator is 30-60rpm, standingly after stirring disappears completely to bubble, obtains polysaccharide polymer aqueous solution standby;
4. the polysaccharide polymer aqueous solution that 3. the hydrophilic polymer aqueous solution of 2. step being prepared and step are prepared, add again HP-β-CD, beet red, hydroxypropyl emthylcellulose, fibroin albumen, poloxamer, ε-poly-D-lysine and remaining water, rapid stirring 1-3h after mixing, mixing speed is 80-100rpm, and whipping temp is 60-70 ℃; Middling speed stirs 2-5h again, and mixing speed is 50-70rpm, and whipping temp is 40-50 ℃; Low rate mixing 1-3h under negative pressure again, mixing speed is 10-30rpm, and whipping temp is 60-70 ℃, and pressure is 70-80kPa, standingly after stirring disappears completely to bubble, obtains a kind of medical catheter hydrophilic coating liquid.
The preparation method of described a kind of medical catheter hydrophilic coating liquid, prepares every 100g medical catheter hydrophilic coating liquid and comprises the steps:
1. according to following weight, prepare raw material: polyvinyl pyrrolidone 10g, chitosan 3g, HP-β-CD 2g, beet red 3g, hydroxypropyl emthylcellulose 4g, fibroin albumen 1g, poloxamer 0.8g, ε-poly-D-lysine 0.5g, surplus is water;
2. get polyvinyl pyrrolidone 10g and water 30g and mix, after mixing, stir 1.5h, speed of agitator is 60rpm, standingly after stirring disappears completely to bubble, obtains hydrophilic polymer aqueous solution standby;
3. get chitosan 3g and water 9g and mix, after mixing, stir 1.5h, speed of agitator is 60rpm, standingly after stirring disappears completely to bubble, obtains polysaccharide polymer aqueous solution standby;
4. the polysaccharide polymer aqueous solution that 3. the hydrophilic polymer aqueous solution of 2. step being prepared and step are prepared, add again HP-β-CD 2g, beet red 3g, hydroxypropyl emthylcellulose 4g, fibroin albumen 1g, poloxamer 0.8g, ε-poly-D-lysine 0.5g and remaining water, rapid stirring 1h after mixing, mixing speed is 90rpm, and whipping temp is 70 ℃; Middling speed stirs 5h again, and mixing speed is 60rpm, and whipping temp is 40 ℃; Low rate mixing 3h under negative pressure again, mixing speed is 20rpm, and whipping temp is 60 ℃, and pressure is 80kPa, standingly after stirring disappears completely to bubble, obtains a kind of medical catheter hydrophilic coating liquid.
The preparation method of described a kind of medical catheter hydrophilic coating liquid, a kind of medical catheter hydrophilic coating liquid of preparing every 100g comprises the steps:
1. according to following weight, prepare raw material: Polyethylene Glycol 5g, carboxymethyl chitosan 0.1g, HP-β-CD 3g, beet red 2g, hydroxypropyl emthylcellulose 3g, fibroin albumen 2g, poloxamer 0.2g, ε-poly-D-lysine 1g, surplus is water;
2. taking polyethylene glycol 5g and water 20g mix, and after mixing, stir 1h, and speed of agitator is 50rpm, standingly after stirring disappear completely to bubble, obtain hydrophilic polymer aqueous solution standby;
3. get carboxymethyl chitosan 0.1g and water 4g and mix, after mixing, stir 1h, speed of agitator is 50rpm, standingly after stirring disappears completely to bubble, obtains polysaccharide polymer aqueous solution standby;
4. the polysaccharide polymer aqueous solution that 3. the hydrophilic polymer aqueous solution of 2. step being prepared and step are prepared, add again HP-β-CD 3g, beet red 2g, hydroxypropyl emthylcellulose 3g, fibroin albumen 2g, poloxamer 0.2g, ε-poly-D-lysine 1g and remaining water, rapid stirring 2h after mixing, mixing speed is 80rpm, and whipping temp is 65 ℃; Middling speed stirs 3h again, and mixing speed is 50rpm, and whipping temp is 45 ℃; Low rate mixing 2h under negative pressure again, mixing speed is 10rpm, and whipping temp is 65 ℃, and pressure is 70kPa, standingly after stirring disappears completely to bubble, obtains a kind of medical catheter hydrophilic coating liquid.
A using method for medical catheter hydrophilic coating liquid, is immersed in 15-60s in medical catheter hydrophilic coating liquid by medical catheter, after soaking, takes out natural drying 30-40s, then medical catheter is placed in to baking oven 70-80 ℃ of baking 1-1.5h.
The invention has the advantages that: various components are mutually collaborative, after meeting water, increase lubricity at once, coefficient of friction reduces by 90%.The solvent of described coating solution is water, and the volatility of water is lower than the volatility of organic solvent, so the resting period is long, and at the temperature of 50 ℃, seldom, the temperature environment during to use requires low, easy to use volatile quantity; Scribble described coating solution and keep lubricant effect to reach 1 month after medical catheter is being met water, can meet the demand of the medical catheter of long-time use; Before using, without carrying out pretreatment, directly coating solution is contacted with medical catheter, easy to use.HP-β-CD can increase the meltage of water, overcomes water as the little shortcoming of dissolution with solvents amount, and HP-β-CD can form duct, can also carry the medicine of auxiliary treatment in duct; It is red that beet red makes coating solution, in medical catheter attaching process, when the color of the periphery of medical catheter all becomes redness, illustrate and smear evenly, avoid coating solution to smear inhomogeneous, reduce patient's misery, in use, during oven dry, directly degrade, keep the intrinsic colour of medical catheter, do not affect the normal use of medical catheter.Hydroxypropyl emthylcellulose can have slow releasing function to the auxiliary medicine adding, and the time of prolong drug effect, realizes the effect of auxiliary treatment.Fibroin albumen is as a kind of good zymophore, after combining with polysaccharide polymer, can make enzyme bearing capacity stronger, can be combined with multiple human pipeline's repairase, be convenient to repairase to be delivered to pathological changes material, make medical catheter there is the ability of carrying repair medicine.Polyvinylpyrrolidone is fast filming in dry run, this film can blocks air in the intervention of a small amount of moisture, but after directly contacting with water, water-soluble rapidly, make coating hydrophilic fast, medical catheter surface lubrication.Poloxamer improves active, promotes collaborative being cross-linked between each material, adds the speed of fast response, also has the effect of increase-volume and slow release simultaneously.ε-poly-D-lysine has bactericidal action, can improve lubricating ability simultaneously.In preparation process of the present invention, rapid stirring mixes each raw material rapidly and uniformly; Middling speed stir to promote full cross-linked between each raw material, can improve the stability of finished product; Low pressure whipping process can improve boiling point in whipping process at a slow speed, fast by removal of bubbles, further improves stability.
Use procedure of the present invention is simple and convenient, soaks medical catheter more even than spraying, guarantees the lubricity of medical catheter use procedure.
The specific embodiment
A kind of medical catheter hydrophilic coating liquid, raw material by following weight percentage ratio forms: hydrophilic polymer 1-10%, polysaccharide polymer 0.1-5%, HP-β-CD 2-4%, beet red 1-3%, hydroxypropyl emthylcellulose 2-4%, fibroin albumen 1-3%, poloxamer 0.2-1%, ε-poly-D-lysine 0.5-1%, surplus is water.
Described hydrophilic polymer is polyvinyl pyrrolidone, Polyethylene Glycol or polyoxyethylene.
Described polysaccharide polymer is chitosan, carboxymethyl chitosan, carboxylic propyl group chitosan or heparin.
The preparation method of described a kind of medical catheter hydrophilic coating liquid, comprises the steps:
1. according to following weight percentage ratio, prepare raw material: hydrophilic polymer 1-10%, polysaccharide polymer 0.1-5%, HP-β-CD 2-4%, beet red 1-3%, hydroxypropyl emthylcellulose 2-4%, fibroin albumen 1-3%, poloxamer 0.2-1%, ε-poly-D-lysine 0.5-1%, surplus is water;
2. get hydrophilic polymer and water and mix according to weight ratio 1:3-5, after mixing, stir 1-2h, speed of agitator is 30-60rpm, standingly after stirring disappears completely to bubble, obtains hydrophilic polymer aqueous solution standby;
3. get polysaccharide polymer and water and mix according to weight ratio 1:3-5, after mixing, stir 1-2h, speed of agitator is 30-60rpm, standingly after stirring disappears completely to bubble, obtains polysaccharide polymer aqueous solution standby;
4. the polysaccharide polymer aqueous solution that 3. the hydrophilic polymer aqueous solution of 2. step being prepared and step are prepared, add again HP-β-CD, beet red, hydroxypropyl emthylcellulose, fibroin albumen, poloxamer, ε-poly-D-lysine and remaining water, rapid stirring 1-3h after mixing, mixing speed is 80-100rpm, and whipping temp is 60-70 ℃; Middling speed stirs 2-5h again, and mixing speed is 50-70rpm, and whipping temp is 40-50 ℃; Low rate mixing 1-3h under negative pressure again, mixing speed is 10-30rpm, and whipping temp is 60-70 ℃, and pressure is 70-80kPa, standingly after stirring disappears completely to bubble, obtains a kind of medical catheter hydrophilic coating liquid.
The raw materials used percentage by weight of a kind of medical catheter hydrophilic coating liquid of the present invention can have multiple combination:
1. polyvinyl pyrrolidone 10%, chitosan 3%, HP-β-CD 2%, beet red 3%, hydroxypropyl emthylcellulose 4%, fibroin albumen 1%, poloxamer 0.8%, ε-poly-D-lysine 0.5%, surplus is water.
2. Polyethylene Glycol 5%, carboxymethyl chitosan 0.1%, HP-β-CD 3%, beet red 2%, hydroxypropyl emthylcellulose 3%, fibroin albumen 2%, poloxamer 0.2%, ε-poly-D-lysine 1%, surplus is water.
3. polyoxyethylene 1%, carboxylic propyl group chitosan 5%, HP-β-CD 4%, beet red 1%, hydroxypropyl emthylcellulose 2%, fibroin albumen 3%, poloxamer 1%, ε-poly-D-lysine 0.7%, surplus is water.
4. polyvinyl pyrrolidone 6%, heparin 1%, HP-β-CD 2%, beet red 3%, hydroxypropyl emthylcellulose 4%, fibroin albumen 1%, poloxamer 0.8%, ε-poly-D-lysine 0.5%, surplus is water.
5. Polyethylene Glycol 7%, chitosan 5%, HP-β-CD 3%, beet red 2%, hydroxypropyl emthylcellulose 3%, fibroin albumen 2%, poloxamer 0.2%, ε-poly-D-lysine 1%, surplus is water.
6. polyvinyl pyrrolidone 4%, heparin 0.8%, HP-β-CD 4%, beet red 1%, hydroxypropyl emthylcellulose 2%, fibroin albumen 3%, poloxamer 1%, ε-poly-D-lysine 0.7%, surplus is water.
7. polyvinyl pyrrolidone 8%, carboxymethyl chitosan 4%, HP-β-CD 2%, beet red 3%, hydroxypropyl emthylcellulose 4%, fibroin albumen 1%, poloxamer 0.8%, ε-poly-D-lysine 0.5%, surplus is water.
8. polyoxyethylene 3%, carboxylic propyl group chitosan 3% HP-β-CD 3%, beet red 2%, hydroxypropyl emthylcellulose 3%, fibroin albumen 2%, poloxamer 0.2%, ε-poly-D-lysine 1%, surplus is water.
9. polyvinyl pyrrolidone 6%, chitosan 3.5%, HP-β-CD 4%, beet red 1%, hydroxypropyl emthylcellulose 2%, fibroin albumen 3%, poloxamer 1%, ε-poly-D-lysine 0.7%, surplus is water.
A kind of method preparation method of medical catheter hydrophilic coating liquid:
1. the method for a kind of medical catheter hydrophilic coating liquid that every 100g embodiment 1 raw material of preparation forms comprises the steps:
1. according to following weight, prepare raw material: polyvinyl pyrrolidone 10g, chitosan 3g, HP-β-CD 2g, beet red 3g, hydroxypropyl emthylcellulose 4g, fibroin albumen 1g, poloxamer 0.8g, ε-poly-D-lysine 0.5g, surplus is water;
2. get polyvinyl pyrrolidone 10g and water 30g and mix, after mixing, stir 1.5h, speed of agitator is 60rpm, standingly after stirring disappears completely to bubble, obtains hydrophilic polymer aqueous solution standby;
3. get chitosan 3g and water 9g and mix, after mixing, stir 1.5h, speed of agitator is 60rpm, standingly after stirring disappears completely to bubble, obtains polysaccharide polymer aqueous solution standby;
4. the polysaccharide polymer aqueous solution that 3. the hydrophilic polymer aqueous solution of 2. step being prepared and step are prepared, add again HP-β-CD 2g, beet red 3g, hydroxypropyl emthylcellulose 4g, fibroin albumen 1g, poloxamer 0.8g, ε-poly-D-lysine 0.5g and remaining water, rapid stirring 1h after mixing, mixing speed is 90rpm, and whipping temp is 70 ℃; Middling speed stirs 5h again, and mixing speed is 60rpm, and whipping temp is 40 ℃; Low rate mixing 3h under negative pressure again, mixing speed is 20rpm, and whipping temp is 60 ℃, and pressure is 80kPa, standingly after stirring disappears completely to bubble, obtains a kind of medical catheter hydrophilic coating liquid.
2. the method for a kind of medical catheter hydrophilic coating liquid that every 100g embodiment 2 raw materials of preparation form comprises the steps:
1. according to following weight, prepare raw material: Polyethylene Glycol 5g, carboxymethyl chitosan 0.1g, HP-β-CD 3g, beet red 2g, hydroxypropyl emthylcellulose 3g, fibroin albumen 2g, poloxamer 0.2g, ε-poly-D-lysine 1g, surplus is water;
2. taking polyethylene glycol 5g and water 20g mix, and after mixing, stir 1h, and speed of agitator is 50rpm, standingly after stirring disappear completely to bubble, obtain hydrophilic polymer aqueous solution standby;
3. get carboxymethyl chitosan 0.1g and water 4g and mix, after mixing, stir 1h, speed of agitator is 50rpm, standingly after stirring disappears completely to bubble, obtains polysaccharide polymer aqueous solution standby;
4. the polysaccharide polymer aqueous solution that 3. the hydrophilic polymer aqueous solution of 2. step being prepared and step are prepared, add again HP-β-CD 3g, beet red 2g, hydroxypropyl emthylcellulose 3g, fibroin albumen 2g, poloxamer 0.2g, ε-poly-D-lysine 1g and remaining water, rapid stirring 2h after mixing, mixing speed is 80rpm, and whipping temp is 65 ℃; Middling speed stirs 3h again, and mixing speed is 50rpm, and whipping temp is 45 ℃; Low rate mixing 2h under negative pressure again, mixing speed is 10rpm, and whipping temp is 65 ℃, and pressure is 70kPa, standingly after stirring disappears completely to bubble, obtains a kind of medical catheter hydrophilic coating liquid.
3. the method for a kind of medical catheter hydrophilic coating liquid that the every 100g above-mentioned raw materials of preparation forms comprises the steps:
1. according to following weight, prepare raw material: polyoxyethylene 1g, carboxylic propyl group chitosan 5g, HP-β-CD 4g, beet red 1g, hydroxypropyl emthylcellulose 2g, fibroin albumen 3g, poloxamer 1g, ε-poly-D-lysine 0.7g, surplus is water;
2. get polyoxyethylene 1g and water 5g and mix, after mixing, stir 2h, speed of agitator is 30rpm, standingly after stirring disappears completely to bubble, obtains hydrophilic polymer aqueous solution standby;
3. get carboxylic propyl group chitosan 5g and water 25g and mix, after mixing, stir 2h, speed of agitator is 30rpm, standingly after stirring disappears completely to bubble, obtains polysaccharide polymer aqueous solution standby;
4. the polysaccharide polymer aqueous solution that 3. the hydrophilic polymer aqueous solution of 2. step being prepared and step are prepared, add again HP-β-CD 4g, beet red 1g, hydroxypropyl emthylcellulose 2g, fibroin albumen 3g, poloxamer 1g, ε-poly-D-lysine 0.7g and remaining water, rapid stirring 3h after mixing, mixing speed is 100rpm, and whipping temp is 60 ℃; Middling speed stirs 2h again, and mixing speed is 70rpm, and whipping temp is 50 ℃; Low rate mixing 1h under negative pressure again, mixing speed is 30rpm, and whipping temp is 70 ℃, and pressure is 75kPa, standingly after stirring disappears completely to bubble, obtains a kind of medical catheter hydrophilic coating liquid.
The using method of medical catheter hydrophilic coating liquid: medical catheter is immersed in to a 15-60s in medical catheter hydrophilic coating liquid, takes out natural drying 30-40s after soaking, then medical catheter is placed in to baking oven 70-80 ℃ of baking 1-1.5h.
Claims (8)
1. a medical catheter hydrophilic coating liquid, it is characterized in that: the raw material by following weight percentage ratio forms: hydrophilic polymer 1-10%, polysaccharide polymer 0.1-5%, HP-β-CD 2-4%, beet red 1-3%, hydroxypropyl emthylcellulose 2-4%, fibroin albumen 1-3%, poloxamer 0.2-1%, ε-poly-D-lysine 0.5-1%, surplus is water.
2. a kind of medical catheter hydrophilic coating liquid according to claim 1, is characterized in that: described hydrophilic polymer is polyvinyl pyrrolidone, Polyethylene Glycol or polyoxyethylene.
3. a kind of medical catheter hydrophilic coating liquid according to claim 1, is characterized in that: described polysaccharide polymer is chitosan, carboxymethyl chitosan, carboxylic propyl group chitosan or heparin.
4. a kind of medical catheter hydrophilic coating liquid according to claim 1, it is characterized in that: the raw material by following weight percentage ratio forms: polyvinyl pyrrolidone 10%, chitosan 3%, HP-β-CD 2%, beet red 3%, hydroxypropyl emthylcellulose 4%, fibroin albumen 1%, poloxamer 0.8%, ε-poly-D-lysine 0.5%, surplus is water.
5. a kind of medical catheter hydrophilic coating liquid according to claim 1, it is characterized in that: the raw material by following weight percentage ratio forms: Polyethylene Glycol 5%, carboxymethyl chitosan 0.1%, HP-β-CD 3%, beet red 2%, hydroxypropyl emthylcellulose 3%, fibroin albumen 2%, poloxamer 0.2%, ε-poly-D-lysine 1%, surplus is water.
6. a kind of medical catheter hydrophilic coating liquid according to claim 1, it is characterized in that: the raw material by following weight percentage ratio forms: polyoxyethylene 1%, carboxylic propyl group chitosan 5%, HP-β-CD 4%, beet red 1%, hydroxypropyl emthylcellulose 2%, fibroin albumen 3%, poloxamer 1%, ε-poly-D-lysine 0.7%, surplus is water.
7. the preparation method of a kind of medical catheter hydrophilic coating liquid according to claim 1: it is characterized in that: comprise the steps:
1. according to following weight percentage ratio, prepare raw material: hydrophilic polymer 1-10%, polysaccharide polymer 0.1-5%, HP-β-CD 2-4%, beet red 1-3%, hydroxypropyl emthylcellulose 2-4%, fibroin albumen 1-3%, poloxamer 0.2-1%, ε-poly-D-lysine 0.5-1%, surplus is water;
2. get hydrophilic polymer and water and mix according to weight ratio 1:3-5, after mixing, stir 1-2h, speed of agitator is 30-60rpm, standingly after stirring disappears completely to bubble, obtains hydrophilic polymer aqueous solution standby;
3. get polysaccharide polymer and water and mix according to weight ratio 1:3-5, after mixing, stir 1-2h, speed of agitator is 30-60rpm, standingly after stirring disappears completely to bubble, obtains polysaccharide polymer aqueous solution standby;
4. the polysaccharide polymer aqueous solution that 3. the hydrophilic polymer aqueous solution of 2. step being prepared and step are prepared, add again HP-β-CD, beet red, hydroxypropyl emthylcellulose, fibroin albumen, poloxamer, ε-poly-D-lysine and remaining water, rapid stirring 1-3h after mixing, mixing speed is 80-100rpm, and whipping temp is 60-70 ℃; Middling speed stirs 2-5h again, and mixing speed is 50-70rpm, and whipping temp is 40-50 ℃; Low rate mixing 1-3h under negative pressure again, mixing speed is 10-30rpm, and whipping temp is 60-70 ℃, and pressure is 70-80kPa, standingly after stirring disappears completely to bubble, obtains a kind of medical catheter hydrophilic coating liquid.
8. the preparation method of a kind of medical catheter hydrophilic coating liquid according to claim 7: it is characterized in that: prepare every 100g medical catheter hydrophilic coating liquid and comprise the steps:
1. according to following weight, prepare raw material: polyvinyl pyrrolidone 10g, chitosan 3g, HP-β-CD 2g, beet red 3g, hydroxypropyl emthylcellulose 4g, fibroin albumen 1g, poloxamer 0.8g, ε-poly-D-lysine 0.5g, surplus is water;
2. get polyvinyl pyrrolidone 10g and water 30g and mix, after mixing, stir 1.5h, speed of agitator is 60rpm, standingly after stirring disappears completely to bubble, obtains hydrophilic polymer aqueous solution standby;
3. get chitosan 3g and water 9g and mix, after mixing, stir 1.5h, speed of agitator is 60rpm, standingly after stirring disappears completely to bubble, obtains polysaccharide polymer aqueous solution standby;
4. the polysaccharide polymer aqueous solution that 3. the hydrophilic polymer aqueous solution of 2. step being prepared and step are prepared, add again HP-β-CD 2g, beet red 3g, hydroxypropyl emthylcellulose 4g, fibroin albumen 1g, poloxamer 0.8g, ε-poly-D-lysine 0.5g and remaining water, rapid stirring 1h after mixing, mixing speed is 90rpm, and whipping temp is 70 ℃; Middling speed stirs 5h again, and mixing speed is 60rpm, and whipping temp is 40 ℃; Low rate mixing 3h under negative pressure again, mixing speed is 20rpm, and whipping temp is 60 ℃, and pressure is 80kPa, standingly after stirring disappears completely to bubble, obtains a kind of medical catheter hydrophilic coating liquid.
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| CN106634491A (en) * | 2016-12-09 | 2017-05-10 | 苏州艾博迈尔新材料有限公司 | Hydrophilic lubrication coating of medical intervention material and preparation method of hydrophilic lubrication coating |
| CN108359635B (en) * | 2018-02-06 | 2019-04-05 | 广州大学 | One kind being used for enriching and purifying c-kit+Composite coating of heart cell and preparation method thereof |
| CN109758617B (en) * | 2019-03-11 | 2022-06-03 | 宁波光远致信生物科技有限公司 | Nerve repair membrane and preparation method and application thereof |
| CN110402928A (en) * | 2019-08-08 | 2019-11-05 | 杭州博菲医疗器械有限公司 | A kind of bacteria resistance function liquid and the conduit tube component using the bacteria resistance function liquid |
| CN110665070B (en) * | 2019-10-13 | 2020-11-10 | 四川大学 | Medical coating with hydrophilic lubricating surface and preparation method thereof |
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| US20020120333A1 (en) * | 2001-01-31 | 2002-08-29 | Keogh James R. | Method for coating medical device surfaces |
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| CN103418033A (en) | 2013-12-04 |
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