CN103340846B - A kind of Arachidonic acid soft capsule and preparation method - Google Patents
A kind of Arachidonic acid soft capsule and preparation method Download PDFInfo
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Abstract
A kind of Arachidonic acid soft capsule of the present invention and preparation method, be made up of content and softgel shell two parts, and content is made up of arachidonic acid oil 80 ~ 130 parts, 2 ~ 6 parts, Cera Flava and composite antioxidant 0.05 ~ 0.1 part; Softgel shell is made up of arabic gum 5 ~ 10 parts, 25 ~ 40 parts, gelatin, glycerol 30 ~ 50 parts, 15 ~ 30 parts, water, covering agent 0.2 ~ 0.5 part, antiseptic 0.05 ~ 0.08 part and disintegrating agent 1.3 ~ 2 parts.Arachidonic acid soft capsule of the present invention and preparation method, formula is reasonable, manufacture method is easy, can effectively prevent arachidonic acid oxidase, Shelf-life, prepare that product carries, taking convenience simultaneously, hide odor effect better, solve the problem of the non-oxidizability of Arachidonic acid soft capsule product, stability and disintegrative simultaneously.
Description
Technical field
The invention belongs to the preparation of soft capsule, particularly relate to a kind of Arachidonic acid soft capsule and preparation method.
Background technology
Arachidonic acid, chemical name is 5,8,11,14-eicosatetraenoic acid, belongs to ω-6 Series P UFAS, there is promotion infant growth, brain healthy, improve the important health cares such as vision, immunomodulating, angiocardiopathy preventing, be the polyunsaturated fat meal of needed by human, cannot self synthesize in human body, need exogenous supplementing.Under normal temperature and pressure, arachidonic acid oil is the pale yellowish oil liquid with slight fishlike smell, and water soluble forms stable emulsion, without precipitation.Because ARA contains 4 unsaturated double-bonds, therefore its character is unstable, oxidizablely in atmosphere becomes sour, and be easily polymerized under high temperature or illumination condition, the reaction such as isomerization.But existing arachidonic acid product focuses mostly in the exploitation of microcapsule product, the complex manufacturing technology of soft gel products, and the product water content produced is higher than microcapsule product, and shelf life is relatively short.There is provided a kind of shelf life Arachidonic acid soft capsule that is long, easy to carry, that be beneficial to absorption to be very necessary, but the Arachidonic acid soft capsule product that non-oxidizability is strong, light-proofness is good, disintegration time is suitable have not been reported.
Summary of the invention
The present invention is intended to overcome the deficiencies in the prior art, provide a kind of Arachidonic acid soft capsule and preparation method, can effectively prevent arachidonic acid oxidase, Shelf-life, prepare practical and convenient product simultaneously, solve the problem of the non-oxidizability of Arachidonic acid soft capsule product, stability and disintegrative.
A kind of Arachidonic acid soft capsule of the present invention, is made up of content and softgel shell two parts, and content is made up of arachidonic acid oil 80 ~ 130 parts, 2 ~ 6 parts, Cera Flava and composite antioxidant 0.05 ~ 0.1 part; Wherein said composite antioxidant is mixed by procyanidin 0.2 ~ 0.4 part, tea polyphenols 0.2 ~ 0.4 part, tertiarybutylhydroquinone 0.08 ~ 0.2 part;
Softgel shell is made up of arabic gum 5 ~ 10 parts, 25 ~ 40 parts, gelatin, glycerol 30 ~ 50 parts, 15 ~ 30 parts, water, covering agent 0.2 ~ 0.5 part, antiseptic 0.05 ~ 0.08 part, disintegrating agent 1.3 ~ 2 parts; Described covering agent is mixed by carmine pigment 1 ~ 3 part and brilliant black pigment 1 ~ 2 part; Antiseptic is mixed by p-Hydroxybenzoate 4 ~ 6 parts and propyl p-hydroxybenzoate 1 ~ 2 part; Disintegrating agent is PEG400;
Its preparation method is:
(1) preparation of content:
A, that arachidonic acid oil, Cera Flava and composite antioxidant are crossed 100 ~ 140 mesh sieves is for subsequent use;
B, the Cera Flava getting 2 ~ 6 parts are added in the arachidonic acid oil of 80 ~ 130 parts, are heated to 65 ~ 85 DEG C, heat while stirring, to all dissolving;
C, the composite antioxidant of 0.05 ~ 0.1 part to be added in the obtained mixed liquor of b step again, slowly stir, naturally cool to room temperature, for subsequent use;
(2) preparation of softgel shell material:
A, gelatin 1 ~ 2 hour with the water soaking 25 ~ 40 parts of the arabic gum 1 ~ 2 hour, 7.5 ~ 15 parts of the water soakings 5 ~ 10 parts of 4.5 ~ 9 parts, for subsequent use;
B, the glycerol of the water of 3 ~ 6 parts with 30 ~ 50 parts to be mixed, stir, more slowly add soaked arabic gum and gelatin in a step, stir, then vacuum outgas is carried out to this glue;
C, in the mixed glue solution that b step is obtained, add covering agent 0.2 ~ 0.5 part, antiseptic 0.05 ~ 0.08 part, disintegrating agent 1.3 ~ 2 parts, be stirred to color even at 60 ~ 70 DEG C after; Stirringization glue under-0.08 ~-0.06MPa, 60 ~ 70 DEG C of conditions, when gelatin viscosity is when 2.8 ~ 3.1mPa.S, water content are 31% ~ 35%, endization glue; Be cooled to 40 ~ 60 DEG C of insulations for subsequent use;
(3) preparation of finished product:
Obtained softgel shell material in content obtained in (1) step and (2) step is placed in encapsulating machine, carry out pelleting, controlling sprinkler body temperature during pelleting is 36 ~ 38 DEG C, contents temperature 36 ~ 40 DEG C, glue temperature 58 DEG C ~ 63 DEG C, the capsule made is put into drying machine rotating cage and carry out that dynamically air-dry to carry out sizing dry, 7 ~ 8 hours drying times, carry out washing ball and polishing with the ethanol of 95% after dry, finally capsule is placed on standing and drying on rustless steel hull, 14 ~ 16 hours drying times, packaging i.e. obtained Arachidonic acid soft capsule.
As preferred component of the present invention, described content is made up of arachidonic acid oil 90 ~ 115 parts, 3 ~ 5 parts, Cera Flava and composite antioxidant 0.07 ~ 0.09 part; Wherein said composite antioxidant is mixed by procyanidin 0.2 ~ 0.3 part, tea polyphenols 0.3 ~ 0.4 part, tertiarybutylhydroquinone 0.1 ~ 0.15 part;
Softgel shell is made up of arabic gum 7 ~ 9 parts, 30 ~ 35 parts, gelatin, glycerol 35 ~ 45 parts, 20 ~ 25 parts, water, covering agent 0.3 ~ 0.4 part, antiseptic 0.06 ~ 0.07 part, disintegrating agent 1.5 ~ 1.8 parts; Wherein said covering agent is mixed by carmine pigment 1 ~ 2 part and brilliant black pigment 1.5 ~ 2 parts; Antiseptic is mixed by p-Hydroxybenzoate 4 ~ 5 parts and propyl p-hydroxybenzoate 1 ~ 2 part; Disintegrating agent is PEG400.
In the present invention, select Cera Flava as suspending agent, the content of preparation is fine and smooth evenly, sedimentation is slow, not stratified, good stability, effectively can prevent leakage of oil, prevent the shortcomings such as uneven, the easy layering of content shape, instability, the accuracy of loading amount can also be improved.
In softgel shell, the arabic gum selected, gelatin do softgel shell, and it is obviously better than using arabic gum merely, or uses gelatin merely.Gelatin can by autoxidation or with functional groups as aldehyde radical interacts, occur in molecule or intermolecular cross-linking reaction.Gelatin produces the tough and tensile and springy water-insoluble pellicle of one deck soft capsule is surface-crosslinked, becomes the barrier stoping content release, cause the disintegrate of soft capsule and stripping defective.If cross-linking reaction occurs gelatin, also soft capsule shell ageing hardening can be caused.The cross-linking reaction of gelatin is subject to the impact of external environment, and temperature raises can accelerate gelatin cross-linking reaction speed, and high humidity environment can catalysis gelatin cross-linking reaction occur, and the soft capsule dissolution rate be exposed under ultraviolet and visible ray can reduce.It is more remarkable on the impact that gelatin is crosslinked when temperature, humidity, these three kinds of factors of light act on simultaneously.Arabic gum is the mixture of the calcium salt of the arabic acid of the sugary and hemicellulose of structure, magnesium salt and potassium salt, and in soft capsule shell, add the arabic gum of proper proportion, shell effectively avoids the generation of cross-linking reaction.
The superiority of composite antioxidant: during different antioxidant compound use, its antioxidant effect is better than the antioxidant effect of independent a kind of antioxidant.Because during two or more antioxidant compound use, various antioxidant is after antioxidation, and the free radical of generation can interact and generate new phenolic compound, continues to play antioxidation, its non-oxidizability can be strengthened.Composite antioxidant produces cooperative effect, synergy, and impel antioxidant to give play to superior antioxygenic property, its antioxidant activity is high, volatility is low.
The effect of disintegrating agent: disintegrating agent has good water absorption and dilatancy, can make soft capsule split rapidly in gastro-intestinal Fluid broken, discharge content, makes the rapid solution absorption of functional component, plays a role.
Arachidonic acid soft capsule of the present invention and preparation method, formula is reasonable, manufacture method is easy, can effectively prevent arachidonic acid oxidase, Shelf-life, prepare that product carries, taking convenience simultaneously, hide odor effect better, solve the problem of the non-oxidizability of Arachidonic acid soft capsule product, stability and disintegrative simultaneously.
Detailed description of the invention
Embodiment 1
A kind of Arachidonic acid soft capsule of the present invention, is made up of content and softgel shell two parts, and content is made up of arachidonic acid oil 80 parts, 6 parts, Cera Flava and composite antioxidant 0.05 part;
Softgel shell is made up of arabic gum 5 parts, 40 parts, gelatin, glycerol 30 parts, 30 parts, water, covering agent 0.2 part, antiseptic 0.08 part, disintegrating agent 1.3 parts;
Composite antioxidant in wherein said content is mixed by procyanidin 0.2 part, tea polyphenols 0.4 part, tertiarybutylhydroquinone 0.08 part;
Covering agent in described softgel shell is mixed by carmine pigment 1 part and brilliant black pigment 2 parts; Antiseptic is mixed by p-Hydroxybenzoate 4 parts and propyl p-hydroxybenzoate 2 parts; Disintegrating agent is PEG400.
Obtained by following method:
First, composite antioxidant, covering agent, antiseptic and disintegrating agent are made for subsequent use by above-mentioned component and proportioning; Moisture is become three parts, is respectively 30%, 20%, 50% for subsequent use.
(1) preparation of content:
A, that arachidonic acid oil, Cera Flava and composite antioxidant are crossed 100 ~ 140 mesh sieves is for subsequent use; Its objective is removing impurity, ensure homogenize material, exquisiteness;
B, get Cera Flava and be added in arachidonic acid oil, be heated to 65 ~ 85 DEG C, heat while stirring, to all dissolving;
C, composite antioxidant to be added in the obtained mixed liquor of b step again, slowly stir, naturally cool to room temperature, for subsequent use;
(2) preparation of softgel shell material:
A, water (i.e. the water of 9 parts) with 30% soak arabic gum 1 ~ 2 hour, water (i.e. the water of the 15 parts) soaking gelatin of 50% 1 ~ 2 hour, for subsequent use;
B, water (i.e. the water of 6 parts) by 20% mix with glycerol, stir, more slowly add soaked arabic gum and gelatin in a step, stir, then carry out vacuum outgas to this glue;
C, in the mixed glue solution that b step is obtained, add covering agent, antiseptic, disintegrating agent, be stirred to color even at 60 ~ 70 DEG C after; Stirringization glue under-0.08 ~-0.06MPa, 60 ~ 70 DEG C of conditions, when gelatin viscosity is when 2.8 ~ 3.1mPa.S, water content are 31% ~ 35%, endization glue; Be cooled to 40 ~ 60 DEG C of insulations for subsequent use;
(3) preparation of finished product:
Obtained softgel shell material in content obtained in (1) step and (2) step is placed in encapsulating machine, carry out pelleting, controlling sprinkler body temperature during pelleting is 37 DEG C, contents temperature 40 DEG C, glue temperature 58 DEG C ~ 63 DEG C, the capsule made is put into drying machine rotating cage and carry out that dynamically air-dry to carry out sizing dry, 7 ~ 8 hours drying times, carry out washing ball and polishing with the ethanol of 95% after dry, finally capsule is placed on standing and drying 14 ~ 16 hours on rustless steel hull, packaging i.e. obtained Arachidonic acid soft capsule.
Embodiment 2
A kind of Arachidonic acid soft capsule of the present invention, is made up of content and softgel shell two parts, and content is made up of arachidonic acid oil 130 parts, 2 parts, Cera Flava and composite antioxidant 0.1 part; Wherein said composite antioxidant is mixed by procyanidin 0.4 part, tea polyphenols 0.2 part, tertiarybutylhydroquinone 0.2 part;
Softgel shell is made up of arabic gum 10 parts, 25 parts, gelatin, glycerol 50 parts, 15 parts, water, covering agent 0.5 part, antiseptic 0.05 part, disintegrating agent 2 parts; Described covering agent is mixed by carmine pigment 3 parts and brilliant black pigment 1 part; Antiseptic is mixed by p-Hydroxybenzoate 6 parts and propyl p-hydroxybenzoate 1 part; Disintegrating agent is PEG400;
Its preparation method is with embodiment 1.
Embodiment 3
A kind of Arachidonic acid soft capsule of the present invention, is made up of content and softgel shell two parts, and content is made up of arachidonic acid oil 90 parts, 5 parts, Cera Flava and composite antioxidant 0.07 part; Wherein said composite antioxidant is mixed by procyanidin 0.2 part, tea polyphenols 0.4 part, tertiarybutylhydroquinone 0.1 part;
Softgel shell is made up of arabic gum 7 parts, 35 parts, gelatin, glycerol 35 parts, 25 parts, water, covering agent 0.3 part, antiseptic 0.07 part, disintegrating agent 1.8 parts; Described covering agent is mixed by carmine pigment 1 part and brilliant black pigment 2 parts; Antiseptic is mixed by p-Hydroxybenzoate 4 parts and propyl p-hydroxybenzoate 2 parts; Disintegrating agent is PEG400;
Its preparation method is with embodiment 1.
Embodiment 4
A kind of Arachidonic acid soft capsule of the present invention, is made up of content and softgel shell two parts, and content is made up of arachidonic acid oil 115 parts, 3 parts, Cera Flava and composite antioxidant 0.09 part; Wherein said composite antioxidant is mixed by procyanidin 0.3 part, tea polyphenols 0.3 part, tertiarybutylhydroquinone 0.15 part;
Softgel shell is made up of arabic gum 9 parts, 30 parts, gelatin, glycerol 45 parts, 20 parts, water, covering agent 0.4 part, antiseptic 0.06 part, disintegrating agent 1.5 parts; Described covering agent is mixed by carmine pigment 2 parts and brilliant black pigment 1.5 parts; Antiseptic is mixed by p-Hydroxybenzoate 5 parts and propyl p-hydroxybenzoate 1 part; Disintegrating agent is PEG400;
Its preparation method is with embodiment 1.
Embodiment 5
A kind of Arachidonic acid soft capsule of the present invention, is made up of content and softgel shell two parts, and content is made up of arachidonic acid oil 100 parts, 4 parts, Cera Flava and composite antioxidant 0.08 part; Wherein said composite antioxidant is mixed by procyanidin 0.25 part, tea polyphenols 0.35 part, tertiarybutylhydroquinone 0.12 part;
Softgel shell is made up of arabic gum 8 parts, 32 parts, gelatin, glycerol 40 parts, 23 parts, water, covering agent 0.35 part, antiseptic 0.065 part, disintegrating agent 1.7 parts; Described covering agent is mixed by carmine pigment 1.5 parts and brilliant black pigment 1.8 parts; Antiseptic is mixed by p-Hydroxybenzoate 4.5 parts and propyl p-hydroxybenzoate 1.5 parts; Disintegrating agent is PEG400;
Its preparation method is with embodiment 1.
A kind of Arachidonic acid soft capsule that embodiment 1 ~ 5 is obtained, under equal storage condition, the comparable ARA microcapsule product of its shelf life extends 1 ~ 2 month; Place 6 months under equal conditions, its peroxide value is 84.37% of ARA microcapsule product.
Claims (3)
1. an Arachidonic acid soft capsule, is made up of content and softgel shell two parts, it is characterized in that content is made up of arachidonic acid oil 80 ~ 130 parts, 2 ~ 6 parts, Cera Flava and composite antioxidant 0.05 ~ 0.1 part;
Softgel shell is made up of arabic gum 5 ~ 10 parts, 25 ~ 40 parts, gelatin, glycerol 30 ~ 50 parts, 15 ~ 30 parts, water, covering agent 0.2 ~ 0.5 part, antiseptic 0.05 ~ 0.08 part and disintegrating agent 1.3 ~ 2 parts;
Composite antioxidant in wherein said content is mixed by procyanidin 0.2 ~ 0.4 part, tea polyphenols 0.2 ~ 0.4 part, tertiarybutylhydroquinone 0.08 ~ 0.2 part;
Covering agent in described softgel shell is mixed by carmine pigment 1 ~ 3 part and brilliant black pigment 1 ~ 2 part; Antiseptic is mixed by p-Hydroxybenzoate 4 ~ 6 parts and propyl p-hydroxybenzoate 1 ~ 2 part; Disintegrating agent is PEG400.
2. a kind of Arachidonic acid soft capsule as claimed in claim 1, is characterized in that content is made up of arachidonic acid oil 90 ~ 115 parts, 3 ~ 5 parts, Cera Flava and composite antioxidant 0.07 ~ 0.09 part;
Softgel shell is made up of arabic gum 7 ~ 9 parts, 30 ~ 35 parts, gelatin, glycerol 35 ~ 45 parts, 20 ~ 25 parts, water, covering agent 0.3 ~ 0.4 part, antiseptic 0.06 ~ 0.07 part, disintegrating agent 1.5 ~ 1.8 parts;
Composite antioxidant in wherein said content is mixed by procyanidin 0.2 ~ 0.3 part, tea polyphenols 0.3 ~ 0.4 part, tertiarybutylhydroquinone 0.1 ~ 0.15 part;
Covering agent in described softgel shell is mixed by carmine pigment 1 ~ 2 part and brilliant black pigment 1.5 ~ 2 parts; Antiseptic is mixed by p-Hydroxybenzoate 4 ~ 5 parts and propyl p-hydroxybenzoate 1 ~ 2 part; Disintegrating agent is PEG400.
3. prepare the preparation method of a kind of Arachidonic acid soft capsule according to claim 1, comprise the following steps:
(1) preparation of content:
A, that arachidonic acid oil, Cera Flava and composite antioxidant are crossed 100 ~ 140 mesh sieves is for subsequent use;
B, the Cera Flava getting 2 ~ 6 parts are added in the arachidonic acid oil of 80 ~ 130 parts, are heated to 65 ~ 85 DEG C, heat while stirring, to all dissolving;
C, the composite antioxidant of 0.05 ~ 0.1 part to be added in the obtained mixed liquor of b step again, slowly stir, naturally cool to room temperature, for subsequent use;
(2) preparation of softgel shell material:
A, gelatin 1 ~ 2 hour with the water soaking 25 ~ 40 parts of the arabic gum 1 ~ 2 hour, 7.5 ~ 15 parts of the water soakings 5 ~ 10 parts of 4.5 ~ 9 parts, for subsequent use;
B, the glycerol of the water of 3 ~ 6 parts with 30 ~ 50 parts to be mixed, stir, more slowly add soaked arabic gum and gelatin in a step, stir, then vacuum outgas is carried out to this glue;
C, in the mixed glue solution that b step is obtained, add covering agent 0.2 ~ 0.5 part, antiseptic 0.05 ~ 0.08 part, disintegrating agent 1.3 ~ 2 parts, be stirred to color even at 60 ~ 70 DEG C after; Stirringization glue under-0.08 ~-0.06MPa, 60 ~ 70 DEG C of conditions, when gelatin viscosity is when 2.8 ~ 3.1mPa.S, water content are 31% ~ 35%, endization glue; Be cooled to 40 ~ 60 DEG C of insulations for subsequent use;
(3) preparation of finished product:
Obtained softgel shell material in content obtained in (1) step and (2) step is placed in encapsulating machine, carry out pelleting, controlling sprinkler body temperature during pelleting is 36 ~ 38 DEG C, contents temperature 36 ~ 40 DEG C, glue temperature 58 DEG C ~ 63 DEG C, the capsule made is put into drying machine rotating cage and carry out that dynamically air-dry to carry out sizing dry, drying time is 7 ~ 8 hours, carry out washing ball and polishing with the ethanol of 95% after dry, finally capsule to be placed on rustless steel hull standing and drying 14 ~ 16 hours, packaging i.e. obtained Arachidonic acid soft capsule.
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