CN108904874A - With membrane-like medical gel, manufacturing method and its application for promoting the effect of surface of a wound wet union - Google Patents
With membrane-like medical gel, manufacturing method and its application for promoting the effect of surface of a wound wet union Download PDFInfo
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- CN108904874A CN108904874A CN201810687565.XA CN201810687565A CN108904874A CN 108904874 A CN108904874 A CN 108904874A CN 201810687565 A CN201810687565 A CN 201810687565A CN 108904874 A CN108904874 A CN 108904874A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dispersion Chemistry (AREA)
- Materials For Medical Uses (AREA)
Abstract
The present invention provides a kind of with the membrane-like medical gel, manufacturing method and its application that promote the effect of surface of a wound wet union, belongs to biomedicine technical field.The present invention forms solution after dissolving alginate and/or pectin with solvent, and solution is imported into freeze forming in mold, is put into cross-linking agent solution crosslinking later, obtains membrane-like medical gel.The present invention has good biocompatibility, non-toxic, has the function of surface of a wound moisturizing and promotes wound healing, can be used for the protection of the clinical surface of a wound and promotes the healing of the surface of a wound.
Description
Technical field
The invention belongs to biomedicine technical fields, are related to a kind of with the membrane-like doctor for promoting the effect of surface of a wound wet union
With gel, manufacturing method and its application.
Background technique
With the development of modern wound care theory, the requirement to Wound care dressing is increasingly improved, and medical dressing is being hurt
Wound is not only covered in mouth nursing application, wound healing is also may advantageously facilitate, build the microenvironment for being conducive to wound healing.
Traditional dressing such as gauze and sponge material only serve the effect of the protection surface of a wound, dressing and the easy adhesion of the surface of a wound, and wound surface is easily grown
Endophytic bacteria, to wound healing without facilitation.Wound wet union theory confirms that the surface of a wound can promote wound in wet environment
Healing, the theory of wound healing is by stemness healing hygrotropism healing conversion, the research of Wound care dressing, production and using also existing
It has a revolutionary change, medical wet dressing gradually replaces traditional dry dressing.
Current moist dressing mainly has bearing hydrocolloid dressing and aerogel dressing.Bearing hydrocolloid dressing is that have hydrophilic macromolecule
Granular materials, hydrocolloid are unsetting colloid sample substance, are needed with hybrid process such as rubber viscous substances into dressing, high water solubility
Molecule particles are easily adhered to and cannot completely be removed on the surface of a wound.Hydrogel also includes unsetting and setting hydrogel, unsetting
Hydrogel is applied to wound surface, there are problems that moisture evaporation and surface of a wound adhesion are not easy to remove.The hydrogel of setting is using poly-
Acrylamide or POLYPROPYLENE GLYCOL hydrogel are that synthetic material preparation has potential toxicity.
Fiber is mainly first processed into using sodium alginate or this kind of materials processing technology of pectin at present, then uses nonwoven
The industrial processing technology of cloth is prepared into textile, is dry dressing, at colloidal after needing to absorb body fluid from the surface of a wound, for drying
This sponge dressing of the surface of a wound it is not applicable.From processing technology, since sodium alginate or pectin solution and calcium ion contact
Crosslinking rapidly, there is presently no the technologies for preparing sodium alginate or pectin aquagel membrane sheet.
Summary of the invention
Regarding the issue above, the present invention provides a kind of with the membrane-like doctor for promoting the effect of surface of a wound wet union
With the manufacturing method of gel.
It is a further object of the present invention to provide a kind of with the membrane-like medical gel for promoting the effect of surface of a wound wet union.
Another object of the present invention be to provide it is a kind of with promote the effect of surface of a wound wet union membrane-like medical gel exist
Application in protection and wound healing.
In order to achieve the above objectives, the present invention provides following technical schemes：
It is a kind of with promote the effect of surface of a wound wet union membrane-like medical gel manufacturing method, by alginate with/
Or pectin dissolved with solvent after form solution, solution is imported into freeze forming in mold, be put into later cross-linking agent solution friendship
Connection, obtains membrane-like medical gel.
Sodium alginate or pectin solution are frozen into ice cube, then slowly molten by ice cube using the principle of science by the present invention
Crosslinked at low temperature is solved, patches aerogel dressing is prepared.
Alginate hydrogel or pectin hydrogel, including alginate or pectin and crosslinking agent, alginate or pectin
Ice crystal is generated after solution freezing, then in cross-linking agent solution, crosslinking substance is diffused into the alginate or pectin being slowly dissolved
In ice cube, effect is crosslinked under cryogenic into hydrogel.
The material no cytotoxicity, without sensitization, it is nonirritant, without general toxicity, hereditary-less toxicity has good
Biocompatibility.Material has good performance of keeping humidity, and the protection that can be used for the clinical surface of a wound promotes the healing of the surface of a wound.
In the above-mentioned manufacturing method with the membrane-like medical gel for promoting the effect of surface of a wound wet union, the sea
Alginates are sodium alginate, potassium alginate and/or ammonium alginate, and the pectin is low methoxy pectin and/or high methoxyl
Pectin, the crosslinking agent are calcium chloride and/or zinc chloride, and the solvent is water or ethanol water.
In the above-mentioned manufacturing method with the membrane-like medical gel for promoting the effect of surface of a wound wet union, the sea
The concentration of alginates and/or pectin solution is respectively 1.5-5wt%, and the cross-linking agent solution concentration is 1.5-5wt%.
In the above-mentioned manufacturing method with the membrane-like medical gel for promoting the effect of surface of a wound wet union, the sea
The concentration of alginates and/or pectin solution be 2wt%, the cross-linking agent solution concentration be 2wt%, the solvent be water or
Ethanol water.
In the above-mentioned manufacturing method with the membrane-like medical gel for promoting the effect of surface of a wound wet union, described is molten
Agent is 75% ethanol water.
In the above-mentioned manufacturing method with the membrane-like medical gel for promoting the effect of surface of a wound wet union, the sea
Alginates and/or pectin solution are freezed between -5 DEG C to -90 DEG C in ice cube, are placed into 0 DEG C -10 DEG C of cross-linking agent solution
Impregnate crosslinking.
In the above-mentioned manufacturing method with the membrane-like medical gel for promoting the effect of surface of a wound wet union, the sea
Be additionally added in alginates and/or pectin solution one of sodium chloride, glucose, amino acid, vitamin and growth factor or
It is several.
In the above-mentioned manufacturing method with the membrane-like medical gel for promoting the effect of surface of a wound wet union, the friendship
The connection time is 12-24hr.
It is a kind of with promote the effect of surface of a wound wet union membrane-like medical gel protection with wound healing in
Using.
It is a kind of to be made according to the above-mentioned manufacturing method with the membrane-like medical gel for promoting the effect of surface of a wound wet union
Have promote the effect of surface of a wound wet union membrane-like medical gel.
Compared with prior art, the advantage of the invention is that：The present invention uses sodium alginate or pectin solution, pours into pre-
It is freezed in the mold first formulated, the ice cube of freeze forming is then subjected to crosslinked at low temperature in cross-linking agent solution is added, sea is made
Alginates or pectin membrane-like aerogel dressing.The dressing has good biocompatibility, non-toxic.With surface of a wound moisturizing and
The effect for promoting wound healing can be used for the protection of the clinical surface of a wound and promote the healing of the surface of a wound.In addition in the preparation of hydrogel
The drugs such as sodium chloride, glucose, amino acid, vitamin, growth factor can also be added, provide nutrition to the surface of a wound, further promote
Into the regeneration and healing of wound tissue.
Specific embodiment
The present invention will be described in detail for following embodiment, is illustrative without being restrictive, can be according to being limited
Range lists several embodiments, therefore does not depart from the change and modification under present general inventive concept, should belong to guarantor of the invention
Within the scope of shield.
Embodiment 1
2.5 grams of sodium alginates are mixing uniformly to form solution in 100ml water, are added in mold, -5 DEG C of low temperature freezings
At ice cube, it is then placed in into 2% calcium chloride solution and is crosslinked 12 hours formation hydrogels at 4 DEG C.
In the present embodiment, mold can use plastics or the production of metal or other materials, and grid-like, Huo Zheyuan can be made
Shape facilitates solution to pour into and freeze, and the ice cube in mold is dipped into cross-linking agent solution namely calcium chloride solution, and it is anti-to start crosslinking
It answers, and forms hydrogel.
It will be appreciated by those skilled in the art that the shape of mold, size do not limit, the water-setting that can according to need
The size of glue makes.For example it is made into the rectangular column of open top or the cylinder of open top or cylindroid.
2% calcium chloride solution is to add 98g water to be dissolved into the calcium chloride solution that mass concentration is 2% with 2g calcium chloride.With
If lower embodiment is without specified otherwise, crosslinker concentration is mass concentration.
Embodiment 2
1 gram of sodium alginate, 1 gram of low methoxy pectin and 1 gram of high methoxy pectin stir evenly to be formed in 100ml water
Solution is added in mold, and -90 DEG C of low temperature are frozen into ice cube, and then 6 DEG C of crosslinkings 14 are small in the calcium chloride solution of 1.5wt%
When form hydrogel.
Embodiment 3
1.5 grams of sodium alginates and 0.5 gram of pectin after mixing evenly, are added in mold, low temperature-in aqueous solution 100ml
20 DEG C are frozen into ice cube, and then 0 DEG C of immersion in the calcium chloride solution for putting into 5% is crosslinked 24 hours formation hydrogels.
Embodiment 4
1.5 grams of potassium alginates after mixing evenly, are added in mold in aqueous solution 100ml, and -10 DEG C of low temperature are frozen into ice
Then block is cross-linked to form hydrogel at 4 DEG C in the mixed solution of 2%+1% calcium chloride of zinc chloride.
Embodiment 5
5 grams of ammonium alginates after mixing evenly, are added in mold in aqueous solution 100ml, and -30 DEG C of low temperature are frozen into ice
Then block is cross-linked to form hydrogel in 10 DEG C of calcium chloride ethanol water of 2%.
In the present embodiment, the concentration of ethanol water is 75V/V%, namely adds 25ml water to be mixed into second with 75ml ethyl alcohol
Alcohol solution.
Embodiment 6
The ethanol water stirring and dissolving of 1.5 grams of potassium alginates and 1g sodium alginate in 30V/V% adds in solution, then respectively
Enter 0.1g sodium chloride, 0.1g glucose, 0.05g amino acid, 0.05g vitamin, 0.01g growth factor to be added in mold, it is low
- 10 DEG C of temperature is frozen into ice cube, is then cross-linked to form hydrogel at 4 DEG C in the liquor zinci chloridi of 4wt%.
In the present embodiment, amino acid can select in 18 kinds of essential amino acids of needed by human body, also can choose it
His water-soluble amino acids, vitamin can choose water soluble vitamin, such as one or more of vitamin C and B family vitamin,
Growth factor can choose peptide hormone, insulin, epidermal growth factor (EGF), fibroblast growth factor (fibroblast
Growth factor, FGF), blood platelet source proliferation factor (platelet-derived growth factor, PDGF)
And one or more of growth hormone-release inhibiting factor (somatostatin=SRIH).
The effect assessment of embodiment, is detailed in the following table 1.
1) intensity：By the sample preparation in embodiment at the sample of 50mm × 12.5mm, drawn using Material Testing Machine
Stretch strength detection.
2) moisture content：1cm × 1cm is made in sample in embodiment, is placed on after weighing to constant weight in drying box, calculating contains
Water rate.
3) intradermal reaction：According to the method for GB/T16886.10 by the leaching liquor injection 0.2ml of sample in skin, injection
2 hours afterwards, 24 hours and 72 hours observation oedema and red and swollen situation, stimulate the reaction is at 0-1 grades.
4) cytotoxicity：Sample is measured by cell toxicity test specified in GB/T16886.5 using mtt assay, cell
Toxicity is in 0-1 grades of ranges.
5) sensitization test (STT)：Sample is subjected to Skin sensitization by method specified in GB/T16886.10, is not observed
To sensitization.
6) genetoxic：Sample is subjected to AMES test, chromosomal aberration test and mouse by regulation in GB/T16886.3
Lymphoma cell gene mutation test, does not observe Genotoxic Effect.
1 embodiment 1-6 effect assessment of table
It is above-mentioned statistics indicate that, according to the present invention patent manufacture alginate hydrogel or pectin hydrogel, acellular poison
Property, no systemic acute toxi-city have no stimulation, and hereditary-less toxicity has good biocompatibility, can be used for protecting wound surface and rush
Into wound healing, and it is sterilized after be easy to use, meet the requirements of clinical use.
Application examples 1
Male rat is selected, model group, rich woods honey group and example 1 group is randomly divided into, rat is raised 1 at room temperature
It week cuts off rat back and becomes mildewed, make open round wound at back with blade, every rat makes 4 wounds, and rat neck is practical
Adhesive tape is fixed, and is prevented it from licking and is licked drug.
Model group is not administered, and rich woods honey group and example 1 group give rich woods honey respectively and the gel painting of embodiment 1 is spread
Mouthful, one time one day, successive administration 21 days, during which rat was freely eaten, drinks water.Rich woods honey is Belgium Flen Pharma N.V.
Company produces.
Wound healing situation：Observation experiment group Rat Wound Healing situation, including incrustation, decrustation, healing time and naked eyes
See wound recovery situation.
Wound healing rate：1/3/7/14/21 day after modeling, every group is randomly selected 3 rats, using hyaline membrane
Weighing method is traced, quality and area ratio the conversion Wound healing rate for the transparent template for describing the surface of a wound, Wound healing rate are utilized
=(original surface of a wound area-do not heal surface of a wound area)/original surface of a wound area * 100%.
Table 2 is that 3 groups of rat Wound healing situations compare, and table 3 is that 3 groups of rat Wound healing rates compare.
23 groups of rat Wound healing situations of table compare
33 groups of rat Wound healing rates of table compare
N is rat quantity, by table 2 and table 3 it is found that the gel of embodiment 1 is relative to model group, in scab forming time, decrustation
It is significantly increased on time and healing time, is slightly improved relative to rich woods honey group.
Application examples 2
Male rat is selected, embodiment group 1,2 groups of embodiment, 3 groups of embodiment, 4 groups of embodiment, embodiment 5 are randomly divided into
Group and 6 groups of embodiment, rat are raised 1 week at room temperature, cut off rat back and become mildewed, make open round create at back with blade
Mouthful, every rat makes 4 wounds, and the practical adhesive tape of rat neck is fixed, prevents it from licking and lick drug.
The gel smearing that embodiment 1-6 group gives embodiment 1-6 respectively is suitable for reading, and one time one day, successive administration 21 days, during which
Rat is freely eaten, drinks water.
Wound healing situation：Observation experiment group Rat Wound Healing situation, including incrustation, decrustation, healing time and naked eyes
See wound recovery situation.
Wound healing rate：1/3/7/14/21 day after modeling, every group is randomly selected 3 rats, using hyaline membrane
Weighing method is traced, quality and area ratio the conversion Wound healing rate for the transparent template for describing the surface of a wound, Wound healing rate are utilized
=(original surface of a wound area-do not heal surface of a wound area)/original surface of a wound area * 100%.
Table 4 is that 6 groups of rat Wound healing situations compare, and table 5 is that 6 groups of rat Wound healing rates compare.
46 groups of rat Wound healing situations of table compare
56 groups of rat Wound healing rates of table compare
By table 4 and table 5 as it can be seen that difference of the gel of embodiment 1-6 in terms of Wound healing situation and healing rate is not significant.
Specific embodiment described herein is only an example for the spirit of the invention.The neck of technology belonging to the present invention
The technical staff in domain can make various modifications or additions to the described embodiments or replace by a similar method
In generation, however, it does not deviate from the spirit of the invention or beyond the scope of the appended claims.
Claims (10)
1. a kind of manufacturing method with the membrane-like medical gel for promoting the effect of surface of a wound wet union, which is characterized in that will be extra large
Alginates and/or pectin form solution after being dissolved with solvent, and solution is imported into freeze forming in mold, is put into crosslinking later
Agent solution crosslinking, obtains membrane-like medical gel.
2. the manufacturing method with the membrane-like medical gel for promoting the effect of surface of a wound wet union according to claim 1,
It is characterized in that, the alginate is sodium alginate, potassium alginate and/or ammonium alginate, the pectin is low-methoxyl oxygen
Base pectin and/or high methoxy pectin, the crosslinking agent are calcium chloride and/or zinc chloride, and the solvent is water or ethyl alcohol
Aqueous solution.
3. the manufacturer with the membrane-like medical gel for promoting the effect of surface of a wound wet union according to claim 1 or 2
Method, which is characterized in that the concentration 1.5-5wt% of the alginate and/or pectin solution, the cross-linking agent solution concentration
For 1.5-5wt%.
4. the manufacturing method with the membrane-like medical gel for promoting the effect of surface of a wound wet union according to claim 3,
It is characterized in that, the concentration of the alginate and/or pectin solution is 2wt%, the cross-linking agent solution concentration is
2wt%, the solvent are water or ethanol water.
5. the manufacturing method with the membrane-like medical gel for promoting the effect of surface of a wound wet union according to claim 4,
It is characterized in that, the solvent is 75% ethanol water.
6. the manufacturing method with the membrane-like medical gel for promoting the effect of surface of a wound wet union according to claim 1,
It is characterized in that, the alginate and/or pectin solution are freezed between -5 DEG C to -90 DEG C in ice cube, place into 0
Crosslinking is impregnated in DEG C -10 DEG C of cross-linking agent solution.
7. the manufacturing method with the membrane-like medical gel for promoting the effect of surface of a wound wet union according to claim 1,
It is characterized in that, be additionally added in the alginate and/or pectin solution sodium chloride, glucose, amino acid, vitamin and
One or more of growth factor.
8. the manufacturing method with the membrane-like medical gel for promoting the effect of surface of a wound wet union according to claim 1,
It is characterized in that, the crosslinking time is 12-24hr.
9. a kind of membrane-like with promotion surface of a wound wet union effect according to any one of claims 1 to 8 is medical solidifying
Application of the glue in protection and wound healing.
10. a kind of membrane-like with promotion surface of a wound wet union effect according to any one of claims 1 to 8 is medical
The manufacturing method of gel is obtained to have the membrane-like medical gel for promoting the effect of surface of a wound wet union.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201810687565.XA CN108904874A (en) | 2018-06-28 | 2018-06-28 | With membrane-like medical gel, manufacturing method and its application for promoting the effect of surface of a wound wet union |
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|---|---|---|---|
| CN201810687565.XA CN108904874A (en) | 2018-06-28 | 2018-06-28 | With membrane-like medical gel, manufacturing method and its application for promoting the effect of surface of a wound wet union |
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| CN108904874A true CN108904874A (en) | 2018-11-30 |
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| CN201810687565.XA Pending CN108904874A (en) | 2018-06-28 | 2018-06-28 | With membrane-like medical gel, manufacturing method and its application for promoting the effect of surface of a wound wet union |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114797485A (en) * | 2021-01-27 | 2022-07-29 | 中国科学院宁波材料技术与工程研究所 | Aerogel membrane for oil-water separation and heavy metal ion adsorption and preparation method and application thereof |
| CN115531592A (en) * | 2022-10-27 | 2022-12-30 | 李升红 | Skin dressing for realizing efficient skin repair and preparation method thereof |
| CN115671362A (en) * | 2022-11-02 | 2023-02-03 | 河北大学 | Alginic acid polysaccharide polymer gel film agent and preparation method and application thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004082594A2 (en) * | 2003-03-18 | 2004-09-30 | Sk Chemicals Co. Ltd. | Alginate sponge and preparation method thereof |
| CN102258801A (en) * | 2011-06-27 | 2011-11-30 | 武汉纺织大学 | Sponge calcium alginate medical dressing, and preparation method |
| CN105641739A (en) * | 2016-01-31 | 2016-06-08 | 华南理工大学 | Antibacterial and hemostasia compound sponge and preparation method thereof |
| CN106310361A (en) * | 2016-11-02 | 2017-01-11 | 常州市鼎日环保科技有限公司 | Preparation method for hydrocolloid dressing for promoting wound repairing |
| CN107118385A (en) * | 2017-06-20 | 2017-09-01 | 杭州英健生物科技有限公司 | A kind of preparation method and its product of medical alginate sponge or pectin sponge |
| CN107754003A (en) * | 2017-10-19 | 2018-03-06 | 张永华 | A kind of method that bleeding-stopping dressing is prepared with hydrogel |
-
2018
- 2018-06-28 CN CN201810687565.XA patent/CN108904874A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004082594A2 (en) * | 2003-03-18 | 2004-09-30 | Sk Chemicals Co. Ltd. | Alginate sponge and preparation method thereof |
| CN102258801A (en) * | 2011-06-27 | 2011-11-30 | 武汉纺织大学 | Sponge calcium alginate medical dressing, and preparation method |
| CN105641739A (en) * | 2016-01-31 | 2016-06-08 | 华南理工大学 | Antibacterial and hemostasia compound sponge and preparation method thereof |
| CN106310361A (en) * | 2016-11-02 | 2017-01-11 | 常州市鼎日环保科技有限公司 | Preparation method for hydrocolloid dressing for promoting wound repairing |
| CN107118385A (en) * | 2017-06-20 | 2017-09-01 | 杭州英健生物科技有限公司 | A kind of preparation method and its product of medical alginate sponge or pectin sponge |
| CN107754003A (en) * | 2017-10-19 | 2018-03-06 | 张永华 | A kind of method that bleeding-stopping dressing is prepared with hydrogel |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114797485A (en) * | 2021-01-27 | 2022-07-29 | 中国科学院宁波材料技术与工程研究所 | Aerogel membrane for oil-water separation and heavy metal ion adsorption and preparation method and application thereof |
| CN114797485B (en) * | 2021-01-27 | 2023-03-10 | 中国科学院宁波材料技术与工程研究所 | Aerogel membrane for oil-water separation and heavy metal ion adsorption and preparation method and application thereof |
| CN115531592A (en) * | 2022-10-27 | 2022-12-30 | 李升红 | Skin dressing for realizing efficient skin repair and preparation method thereof |
| CN115671362A (en) * | 2022-11-02 | 2023-02-03 | 河北大学 | Alginic acid polysaccharide polymer gel film agent and preparation method and application thereof |
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Application publication date: 20181130 |