CN103417942A

CN103417942A - Preparation method of Huoxiang Zhengqi capsules

Info

Publication number: CN103417942A
Application number: CN2013103507225A
Authority: CN
Inventors: 洪绯; 袁慧君; 林志雄; 郭玉瑜
Original assignee: Zhangzhou Pientzehuang Pharmaceutical Co Ltd
Current assignee: Zhangzhou Pientzehuang Pharmaceutical Co Ltd
Priority date: 2013-08-13
Filing date: 2013-08-13
Publication date: 2013-12-04

Abstract

The invention discloses a preparation method of Huoxiang Zhengqi capsules. The method includes: drying extract cream with belt type vacuum drying, and subjecting the dried materials to simple preparation process to obtain the finished product. By the method, the problems that traditional processes are high in operation difficulty and poor in quality controllability are solved, preparation process procedures are simplified, production efficiency and yield are increased greatly, production cost is lowered, effective component loss is reduced, and quality of intermediate products and finished products is increased.

Description

A kind of preparation method of HUOXIANG ZHENGQI JIAONANG

Technical field

The invention belongs to field of medicine preparing technology, be specifically related to a kind of preparation method of HUOXIANG ZHENGQI JIAONANG.

Background technology

The conventional formulation method of HUOXIANG ZHENGQI JIAONANG pharmaceutical composition is to adopt high speed wet granulation and airpillow-dry, owing to extracting, the cream amount is large, the easy moisture absorption of material, viscosity are large, cause in the high speed wet-granulation process and be prone to material conglomeration in bulk, be prone to the phenomenon of collapsing of luming in the airpillow-dry process, dried material hardness is large simultaneously, and density is low, bring difficulty to follow-up granulate and capsule-filling, and the material recovery rate is low, the airpillow-dry time is long, and the active constituent content loss is larger.

Summary of the invention

The object of the present invention is to provide a kind of preparation method of HUOXIANG ZHENGQI JIAONANG, the invention solves the problem that the traditional handicraft operation easier is large, quality controllability is low, simplified the preparation process step, production efficiency and material recovery rate have greatly been improved, reduce production costs, reduce the loss of effective ingredient, improved the quality of middle product and finished product.

For achieving the above object, the present invention adopts following technical scheme:

A kind of preparation method of HUOXIANG ZHENGQI JIAONANG, the required crude drug of every 1000 HUOXIANG ZHENGQI JIAONANG is:

Herba Pogostemonis 195g Folium Perillae 65g Radix Angelicae Dahuricae 65g Rhizoma Atractylodis Macrocephalae (parched) 130g

Pericarpium Citri Reticulatae 130g Rhizoma Pinelliae Preparatum 130g Cortex Magnoliae Officinalis(processed with ginger) 130g Poria 65g

Radix Platycodonis 130g Radix Glycyrrhizae 130g Pericarpium Arecae 65g Fructus Jujubae 32.5g

Rhizoma Zingiberis Recens 19.5g right amount of auxiliary materials;

Preparation method comprises the following steps:

(1) Rhizoma Pinelliae Preparatum is ground into fine powder, sieves;

(2) steam distillation 1-3 hour for Herba Pogostemonis, Folium Perillae, Pericarpium Citri Reticulatae and Rhizoma Zingiberis Recens, collect distillate, and extraction volatile oil is standby;

(3) after Herba Pogostemonis, Folium Perillae, Pericarpium Citri Reticulatae and gingerade steam distillation, medicinal residues add 6-12 times of water gaging decoction 1-3 time with Poria, Pericarpium Arecae, Radix Platycodonis, Radix Glycyrrhizae and Fructus Jujubae again, each 1-3 hour, filter, merging filtrate, heating concentrates or vacuum concentration to relative density is 1.0-1.2(80 ℃ of mensuration), obtain concentrated solution A;

(4) the alcoholic solution forced circulation that the volume fraction that the Radix Angelicae Dahuricae, Rhizoma Atractylodis Macrocephalae (parched) and Cortex Magnoliae Officinalis(processed with ginger) add 3-6 doubly to measure is 70% 1-3 time, each 2-5 hour, the extraction temperature is 30-60 ℃, filters, merging filtrate, reclaim ethanol, obtains concentrated solution B;

(5) merge concentrated solution A and concentrated solution B, addition method Rhizoma Pinelliae fine powder and appropriate amount of auxiliary materials, mix, adopt the belt boulton process to carry out drying, drying condition is: first paragraph temperature 90-99 ℃, second segment temperature 90-99 ℃, the 3rd section temperature 70-90 ℃, the 4th section temperature 20-30 ℃, charging rate 2000-6000mL/ hour, belt speed 100-1000mm/ minute, pressure-60～-120kPa;

(6) collect the 12-30 eye mesh screen granulate for dried material of step (5), spray into the volatile oil of step (2), total mixed, filled capsules, obtain product.

Remarkable advantage of the present invention is: the invention solves the problem that the traditional handicraft operation easier is large, quality controllability is low, simplified the preparation process step, production efficiency and material recovery rate have greatly been improved, reduce production costs, reduce the loss of effective ingredient, improved the quality of middle product and finished product.

The specific embodiment

Embodiment 1

Rhizoma Zingiberis Recens 19.5g right amount of auxiliary materials;

Preparation method comprises the following steps:

(1) Rhizoma Pinelliae Preparatum is ground into fine powder, sieves;

(2) Herba Pogostemonis, Folium Perillae, Pericarpium Citri Reticulatae and Rhizoma Zingiberis Recens are used steam distillation 1 hour, collect distillate, and extraction volatile oil is standby;

(3) after Herba Pogostemonis, Folium Perillae, Pericarpium Citri Reticulatae and gingerade steam distillation, medicinal residues add 6 times of water gagings decoctions 3 times with Poria, Pericarpium Arecae, Radix Platycodonis, Radix Glycyrrhizae and Fructus Jujubae again, each 1 hour, filter merging filtrate, heating concentrates or vacuum concentration to relative density is 1.0(80 ℃ of mensuration), obtain concentrated solution A;

(4) Radix Angelicae Dahuricae, Rhizoma Atractylodis Macrocephalae (parched) and Cortex Magnoliae Officinalis(processed with ginger) add the alcoholic solution forced circulation 3 times that the volume fraction of 3 times of amounts is 70%, and each 2 hours, extracting temperature was 30 ℃, filter, and merging filtrate, reclaim ethanol, obtains concentrated solution B;

(5) merge concentrated solution A and concentrated solution B, addition method Rhizoma Pinelliae fine powder and appropriate amount of auxiliary materials, mix, adopt the belt boulton process to carry out drying, drying condition is: 90 ℃ of first paragraph temperature, 90 ℃ of second segment temperature, the 3rd section temperature 70 C, 20 ℃ of the 4th section temperature, charging rate 2000mL/ hour, belt speed 100mm/ minute, pressure-60kPa;

(6) collect the 12 eye mesh screen granulate for dried material of step (5), spray into the volatile oil of step (2), total mixed, filled capsules, obtain product.

Embodiment 2

Rhizoma Zingiberis Recens 19.5g right amount of auxiliary materials;

Preparation method comprises the following steps:

(1) Rhizoma Pinelliae Preparatum is ground into fine powder, sieves;

(2) Herba Pogostemonis, Folium Perillae, Pericarpium Citri Reticulatae and Rhizoma Zingiberis Recens are used steam distillation 3 hours, collect distillate, and extraction volatile oil is standby;

(3) after Herba Pogostemonis, Folium Perillae, Pericarpium Citri Reticulatae and gingerade steam distillation, medicinal residues add 12 times of water gagings decoctions 1 time with Poria, Pericarpium Arecae, Radix Platycodonis, Radix Glycyrrhizae and Fructus Jujubae again, each 3 hours, filter, merging filtrate, heating concentrates or vacuum concentration to relative density is 1.2(80 ℃ of mensuration), obtain concentrated solution A;

(4) Radix Angelicae Dahuricae, Rhizoma Atractylodis Macrocephalae (parched) and Cortex Magnoliae Officinalis(processed with ginger) add the alcoholic solution forced circulation 1 time that the volume fraction of 6 times of amounts is 70%, and each 5 hours, extracting temperature was 60 ℃, filter, and merging filtrate, reclaim ethanol, obtains concentrated solution B;

(5) merge concentrated solution A and concentrated solution B, addition method Rhizoma Pinelliae fine powder and appropriate amount of auxiliary materials, mix, adopt the belt boulton process to carry out drying, drying condition is: 99 ℃ of first paragraph temperature, 99 ℃ of second segment temperature, 90 ℃ of the 3rd section temperature, 30 ℃ of the 4th section temperature, charging rate 6000mL/ hour, belt speed 1000mm/ minute, pressure-120kPa;

(6) collect the 30 eye mesh screen granulate for dried material of step (5), spray into the volatile oil of step (2), total mixed, filled capsules, obtain product.

Embodiment 3

Rhizoma Zingiberis Recens 19.5g right amount of auxiliary materials;

Preparation method comprises the following steps:

(1) Rhizoma Pinelliae Preparatum is ground into fine powder, sieves;

(2) Herba Pogostemonis, Folium Perillae, Pericarpium Citri Reticulatae and Rhizoma Zingiberis Recens are used steam distillation 2 hours, collect distillate, and extraction volatile oil is standby;

(3) after Herba Pogostemonis, Folium Perillae, Pericarpium Citri Reticulatae and gingerade steam distillation, medicinal residues add 9 times of water gagings decoctions 2 times with Poria, Pericarpium Arecae, Radix Platycodonis, Radix Glycyrrhizae and Fructus Jujubae again, each 2 hours, filter merging filtrate, heating concentrates or vacuum concentration to relative density is 1.1(80 ℃ of mensuration), obtain concentrated solution A;

(4) Radix Angelicae Dahuricae, Rhizoma Atractylodis Macrocephalae (parched) and Cortex Magnoliae Officinalis(processed with ginger) add the alcoholic solution forced circulation 2 times that the volume fraction of 4.5 times of amounts is 70%, and each 3.5 hours, extracting temperature was 45 ℃, filter, and merging filtrate, reclaim ethanol, obtains concentrated solution B;

(5) merge concentrated solution A and concentrated solution B, addition method Rhizoma Pinelliae fine powder and appropriate amount of auxiliary materials, mix, adopt the belt boulton process to carry out drying, drying condition is: 95 ℃ of first paragraph temperature, 95 ℃ of second segment temperature, 80 ℃ of the 3rd section temperature, 25 ℃ of the 4th section temperature, charging rate 4000mL/ hour, belt speed 550mm/ minute, pressure-90kPa;

(6) collect the 21 eye mesh screen granulate for dried material of step (5), spray into the volatile oil of step (2), total mixed, filled capsules, obtain product.

Prepare respectively HUOXIANG ZHENGQI JIAONANG (crude drug used is same lot number) by traditional handicraft and technique of the present invention, relatively product angle of reposes, capsule loading amount, Magnolol and Honokiol content and the rate of transform in the middle of finished product yield, granule, result is as follows:

Figure 2013103507225100002DEST_PATH_IMAGE002

As seen from the above table, adopt technique of the present invention to prepare HUOXIANG ZHENGQI JIAONANG, because operation is simplified, the finished product recovery rate significantly improves; Solve traditional handicraft and made the middle product poor fluidity of granule, the problem that the capsule loadings is lower; Because the heat drying time is short, greatly reduce content loss simultaneously.

The foregoing is only preferred embodiment of the present invention, all equalizations of doing according to the present patent application the scope of the claims change and modify, and all should belong to covering scope of the present invention.

Claims

1. the preparation method of a HUOXIANG ZHENGQI JIAONANG, it is characterized in that: the required crude drug of every 1000 HUOXIANG ZHENGQI JIAONANG is:

Rhizoma Zingiberis Recens 19.5g right amount of auxiliary materials;

Preparation method comprises the following steps:

(1) Rhizoma Pinelliae Preparatum is ground into fine powder, sieves;

(3) after Herba Pogostemonis, Folium Perillae, Pericarpium Citri Reticulatae and gingerade steam distillation, medicinal residues add 6-12 times of water gaging decoction 1-3 time with Poria, Pericarpium Arecae, Radix Platycodonis, Radix Glycyrrhizae and Fructus Jujubae again, each 1-3 hour, filter merging filtrate, heating concentrates or vacuum concentration to relative density is 1.0-1.2, obtains concentrated solution A;