CN103417661A - Rhizoma coptidis essence and preparation method thereof - Google Patents
Rhizoma coptidis essence and preparation method thereof Download PDFInfo
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- CN103417661A CN103417661A CN2013103486888A CN201310348688A CN103417661A CN 103417661 A CN103417661 A CN 103417661A CN 2013103486888 A CN2013103486888 A CN 2013103486888A CN 201310348688 A CN201310348688 A CN 201310348688A CN 103417661 A CN103417661 A CN 103417661A
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- rhizoma coptidis
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- herpes zoster
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Abstract
The invention discloses a rhizoma coptidis essence and a preparation method thereof. The rhizoma coptidis essence is dry-powder medicine extracted from rhizoma coptidis and is used for inhibiting herpes zoster. The extraction process comprises the following steps: weighing a rhizoma coptidis raw material, cleaning the raw material, and drying in the sun for later use; grinding the standby rhizoma coptidis, and adding water to form powder syrup; heating the powder syrup to 100 DEG C, decocting for 50-70 minutes, and then filtering to obtain filtered liquid; cooling the filtered liquid, adding protease, cellulose and diastase, stirring for a period of time, using edible acetic acid to adjust the pH value to 5.0, and then standing for more than half a day; drying standing liquid to obtain the powder-state traditional Chinese medicine essence for curing herpes zoster. The rhizoma coptidis essence can effectively enhance phagocytosis of a reticuloendothelial system and inhibits and dispels infective inflammation of bacteria, viruses and the like. The extraction process has the advantages of simple steps, convenience in construction and relatively high extraction and is suitable for mass scale production.
Description
Technical field
The present invention relates to a kind of Chinese patent medicine and method for making thereof, relate in particular to a kind of Rhizoma Coptidis essence and method for making thereof, belong to Chinese medicine polish field.
Background technology
Herpes zoster, traditional Chinese medical science tradition is called " herpes zoster ", " spider angioma ", " herpes zoster ", " herpes zoster " etc.Caused by varicella zoster virus (herpes varicella-zoster virus, VZV), with bunch collection property phlysis that distributes along one-sided peripheral nerve as feature, often with obvious neuralgia.Virus can be hidden for a long time in body and do not fallen ill, but, in infecting the patients such as wound tumor and lupus erythematosus, because resistance significantly reduces, easily bring out this disease, and men and women, old and young is easily ill.Premorbid symptom is the scorching hot and tingle of local skin, after one to three day, sends erythra.It is glomerate microcephaly or the large vesicle of Semen phaseoli radiati that this erythra appears at painful area, along neural the distribution, is banded, can be with General Symptomies such as heatings in serious situation.
Existing antiviral drugs commonly used is treated, particularly acyclovir oral liquid, valaciclovir oral liquid etc.But most of this type of medicine can more or less cause the damage to patient's renal function.
Summary of the invention
Demand in view of above-mentioned prior art exists, the objective of the invention is to propose a kind of Rhizoma Coptidis essence and pharmaceutical applications thereof, and propose the Chinese medicine essence extraction process that a kind of effective ingredient extraction is higher.
One of above-mentioned purpose of the present invention Rhizoma Coptidis essence, its technical scheme be achieved is: described Rhizoma Coptidis essence is for extracting from the dry powder state medicine of Rhizoma Coptidis and for suppressing herpes zoster.
The method for making of two Rhizoma Coptidis essences of above-mentioned purpose of the present invention, its technical scheme be achieved comprises operating procedure: I, weighing Rhizoma Coptidis, to carry out routine and clean in stainless steel tank, taking-up is dried standby; II, standby Rhizoma Coptidis is pulverized, smashing fineness reaches 100～150 orders, then adds the water of 10 times of raw material of Chinese medicine gross masses to mix, and makes the powder slurry; III, powder slurry is put into to stainless-steel pan, be heated to 100 ℃, decoct after 50～70 minutes and filter and obtain filtrate; IV, indoor at bacteria-and dust-free, filtrate is poured in the stainless-steel pan with agitating device and stirred, be cooled to below 20 ℃, the protease, 0.15%～0.4% cellulase and 0.15%～0.2% diastase that add again Rhizoma Coptidis weight 0.15%～0.3%, under the condition of 30 beats/mins of rotating speeds, stir 2 hours, and with tablet vinegar acid for adjusting pH value 5.0, more than standing half a day; V, standing liquid is put into to centrifuge dehydration in aseptic temperature control workshop after, produced precipitate is put into to 45 ℃ of electric heating aerator setting constant temperature and carry out drying 8 hours, obtain the Rhizoma Coptidis essence of dry powder state, the 5-7% that the weight of this Rhizoma Coptidis essence is Rhizoma Coptidis raw material gross weight.
The technical scheme of Rhizoma Coptidis essence of the present invention and extraction process thereof, its outstanding effect is: this Rhizoma Coptidis essence can effectively strengthen the phagocytosis of reticuloendothelial system, suppresses and dispels the infective inflammations such as antibacterial, virus.Extraction process step of the present invention is simple in addition, and it is convenient to implement, and extraction is higher, is suitable for scale in batches and produces.
The specific embodiment
Because current, the present situation of recurrence often poor to Herpes Zoster, this case creator concentrate one's attention on the Study of Traditional Chinese Medicine medical knowledge, can effectively prevent and treat Chinese herbal medicine material, the test of herpes zoster through exploration, finally finds technical solution preferably.
After deliberation, the present invention proposes a kind of Rhizoma Coptidis essence, and it is the dry powder state medicine of extraction from Rhizoma Coptidis, and can effectively suppress and treat herpes zoster.
From pharmacology: Rhizoma Coptidis, as a kind of Chinese medicine, has the effect of heat-clearing and toxic substances removing, dampness pathogenic fire purging, is a kind of antiviral important medical material.Rhizoma Coptidis has the antibiosis and antiviral functions of spectrum, and its main mechanism, for suppressing the metabolism of nucleic acid and protein, strengthens leukocytic phagocytosis.The energy activating macrophage, the phagocytosis of enhancing reticuloendothelial system.The infective inflammations such as treatment antibacterial, virus.After being extracted into essence, more suitable to Patients with Herpes Zoster.Therefore the present invention is devoted to development and the extraction of essence.
From the method for making embodiments of the invention, it comprises following operating procedure.
I, weighing Rhizoma Coptidis 15kg carry out routine and clean in stainless steel tank, and taking-up is dried standby; II, standby Rhizoma Coptidis is pulverized, smashing fineness reaches 120 orders, then adds the water of 150kg to mix, and produces the powder slurry; III, powder slurry is put into to stainless-steel pan, be heated to 100 ℃, decoct 60 minutes, then at the blowing valve port, add the filtration cloth bag, then open baiting valve and filtered, obtain filtrate; IV, indoor at bacteria-and dust-free, filtrate is poured in the stainless-steel pan with agitating device and stirred, be cooled to 18 ℃, add again the protease of 0.03kg, the cellulase of 0.045kg and the diastase of 0.025kg, under the condition of 30 beats/mins of rotating speeds, stir 2 hours, and with tablet vinegar acid for adjusting pH value 5.0, standing 24 hours; V, standing liquid is put into to centrifuge dehydration in aseptic temperature control workshop after, produced precipitate is put into to the electric heating aerator and sets 45 ℃ of constant temperature and carry out drying 8 hours, obtain the Rhizoma Coptidis essence of 0.7kg dry powder state.
The embodiment of the present invention is intended to be convenient to understand innovation essence of the present invention; but do not limit the scope of the invention; all simple modification or equivalence are replaced, or utilize this finished product powder processing and fabricating capsule, pill, injection etc., all should be contained among the scope of the present invention.
Medical record is introduced: Rhizoma Coptidis of the present invention is extracted element through development for many years, and its pharmaceutical applications can be treated herpes zoster, and the input clinical trial is evident in efficacy.Certain city Mr. Tao, 55 years old, herpes zoster was suffered from the waist right side, and sufferings are hard to bear, once take antibiotic but curative effect is almost nil, and scorching hot all the time with it, pain is hard to bear.And after being introduced, the Rhizoma Coptidis essence of this product on probation, fully recover in short one week.
As can be seen here, the technical scheme of Rhizoma Coptidis essence of the present invention and extraction process thereof, its outstanding effect is: this Chinese medicine essence can effectively strengthen the phagocytosis of reticuloendothelial system, suppresses and dispels the infective inflammations such as antibacterial, virus.Extraction process step of the present invention is simple in addition, and it is convenient to implement, and extraction is higher, is suitable for scale in batches and produces.
Claims (2)
1. a Rhizoma Coptidis essence is characterized in that: described Rhizoma Coptidis essence is for extracting from the dry powder state medicine of Rhizoma Coptidis and for suppressing herpes zoster.
2. the extraction process of a Rhizoma Coptidis essence, its feature comprises operating procedure:
I, weighing Rhizoma Coptidis carry out routine and clean in stainless steel tank, and taking-up is dried standby;
II, standby Rhizoma Coptidis is pulverized, smashing fineness reaches 100～150 orders, then adds the water of 10 times of raw material of Chinese medicine gross masses to mix, and makes the powder slurry;
III, powder slurry is put into to stainless-steel pan, be heated to 100 ℃, decoct after 50～70 minutes and filter and obtain filtrate;
IV, indoor at bacteria-and dust-free, filtrate is poured in the stainless-steel pan with agitating device and stirred, be cooled to below 20 ℃, the protease, 0.15%～0.4% cellulase and 0.15%～0.2% diastase that add again Rhizoma Coptidis weight 0.15%～0.3%, under the condition of 30 beats/mins of rotating speeds, stir 2 hours, and with tablet vinegar acid for adjusting pH value 5.0, more than standing half a day;
V, standing liquid is put into to centrifuge dehydration in aseptic temperature control workshop after, produced precipitate is put into to 45 ℃ of electric heating aerator setting constant temperature and carry out drying 8 hours, obtain the Rhizoma Coptidis essence of dry powder state, the 5-7% that the weight of this Rhizoma Coptidis essence is Rhizoma Coptidis raw material gross weight.
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| CN2013103486888A CN103417661A (en) | 2013-08-13 | 2013-08-13 | Rhizoma coptidis essence and preparation method thereof |
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| CN2013103486888A CN103417661A (en) | 2013-08-13 | 2013-08-13 | Rhizoma coptidis essence and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105995822A (en) * | 2016-06-01 | 2016-10-12 | 望江县碧春源蜂业有限责任公司 | Traditional Chinese medicine health-care blender prepared from green tea extract compounded with honey and preparation method of traditional Chinese medicine health-care blender |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS523816A (en) * | 1975-06-24 | 1977-01-12 | Kanebo Ltd | A process for preparing berberine type alkaloids |
| CN101695520A (en) * | 2008-12-30 | 2010-04-21 | 天津医科大学 | Preparation method of medicament for treating diabetes |
| JP2011148776A (en) * | 2009-12-22 | 2011-08-04 | Taisho Pharmaceutical Co Ltd | Liquid preparation composition |
| CN102807565A (en) * | 2012-07-30 | 2012-12-05 | 四川农业大学 | Improved method for extracting berberine |
| CN103006685A (en) * | 2012-12-22 | 2013-04-03 | 北华大学 | Coptis chinensis polysaccharide for treating type II diabetes and preparation method thereof |
-
2013
- 2013-08-13 CN CN2013103486888A patent/CN103417661A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS523816A (en) * | 1975-06-24 | 1977-01-12 | Kanebo Ltd | A process for preparing berberine type alkaloids |
| CN101695520A (en) * | 2008-12-30 | 2010-04-21 | 天津医科大学 | Preparation method of medicament for treating diabetes |
| JP2011148776A (en) * | 2009-12-22 | 2011-08-04 | Taisho Pharmaceutical Co Ltd | Liquid preparation composition |
| CN102807565A (en) * | 2012-07-30 | 2012-12-05 | 四川农业大学 | Improved method for extracting berberine |
| CN103006685A (en) * | 2012-12-22 | 2013-04-03 | 北华大学 | Coptis chinensis polysaccharide for treating type II diabetes and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 周家洲: "黄连须根有效成分提取工艺研究", 《中外医疗》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105995822A (en) * | 2016-06-01 | 2016-10-12 | 望江县碧春源蜂业有限责任公司 | Traditional Chinese medicine health-care blender prepared from green tea extract compounded with honey and preparation method of traditional Chinese medicine health-care blender |
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Application publication date: 20131204 |