CN103405397A - Capsule located in bioadhesive drug delivery manner for releasing beta glucosan - Google Patents
Capsule located in bioadhesive drug delivery manner for releasing beta glucosan Download PDFInfo
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- CN103405397A CN103405397A CN2013103853675A CN201310385367A CN103405397A CN 103405397 A CN103405397 A CN 103405397A CN 2013103853675 A CN2013103853675 A CN 2013103853675A CN 201310385367 A CN201310385367 A CN 201310385367A CN 103405397 A CN103405397 A CN 103405397A
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Abstract
The invention relates to a capsule for inhibiting nutrient absorption in a gastrointestinal tract, wherein sodium carboxymethylcellulose is used as the capsule coating of the capsule, and beta glucosan is the ingredient of internal fillers. The capsule is characterized in that the sodium carboxymethylcellulose capsule coating utilizes a bioadhesive drug delivery system as a principle to form floating adhesion when food in the stomach is digested and when the gastrointestinal tract pH changes and enters an intestinal tract to form an intestinal tract inner wall adhesion film so as to prolong the contact time with the gastrointestinal tract; the ingredient in the capsule is the beta glucosan, the beta glucosan can not be absorbed in the stomach and the small intestine and can simultaneously prevent the absorption of sugar, fat, and the like; by means of the characteristics that the sodium carboxymethylcellulose is adhered on the stomach wall and the intestinal wall for a long time to form effective adhesive films, the beta glucosan ingredient in the capsule effectively reduces the absorption of food and nutritional ingredients in the stomach, duodenum and jejunum, and energy and nutrient are limited by reducing the adsorption rate to perfect body weight, blood glucose and blood fat.
Description
Technical field
The present invention relates to a kind of medical apparatus and instruments, particularly a kind of obesity is or/and reduce Stomach duodenum during diabetes and the noinvasive medical apparatus and instruments of jejunum sugar and fat intake.
Background technology
Control the absorption at Stomach duodenum and jejunum of sugar and fat, and the secretion of controlling above-mentioned position Nutrition and Metabolism associated hormone is to improve obesity or/and the key of diabetes.
External by spacious duodenum and/or the jejunum epimere put of " stomach-duodenum " turn of tidal stream by-pass operation, suppress the secretion of nutrient at the absorption at above-mentioned position and change nutrition associated metabolic hormone.Yet the bypass of operation turn of tidal stream can't recover once changing, this gastrointestinal structural change is permanent, brings for a long time the problems such as malnutrition, gastrointestinal tract do not tolerate in the past, also to the patient, brings certain misery when controlling energy and Nutrients Absorption.The people such as the M.Tamoff research in the body of setting forth oversleeve (DJBS) in its Duodeno-jejunum intestinal of publishing an article in 2007, this DJBS sends to through endoscope by one, can fix and expand the interior oversleeve structure that enters jejunum at the duodenum near-end.The intestinal sleeve is identical with the principle of turn of tidal stream operation, but utilizes the biomaterial pipeline to substitute intestinal, and decrease uptake and hormone secretion, reduce wound simultaneously.Yet the zoopery of interior oversleeve and human trial show, its insert and taking-up can bring mucosa compressing ischemia, etc. complication, to the patient, bring other unnecessary miseries.
In diet, the foods such as Herba bromi japonici are the main source of beta glucosan, by the edible food that contains the beta glucosan, can improve blood pressure, blood glucose and blood fat.Yet Chinese population not take at present generally food that Herba bromi japonici etc. contains the beta glucosan and is originated as main diet, and differs from beta beta-dextran content in the food of the different places of production and kind; Simultaneously, because needs adhere to eating for a long time, and need to reach certain amount and just the effect of above-mentioned improvement health may be arranged, therefore, by diet, reach this kind effect interference factor more, edible compliance is poor.The more important thing is, the beta glucosan enters small intestinal with the intestinal normal creepage of gastrointestinal functions from gastric, can't long duration of action at gastrointestinal tract, therefore can't more effectively suppress sugar and fatty absorption.
Summary of the invention
The present invention relates to a kind of medical apparatus and instruments, particularly a kind of obesity is or/and reduce Stomach duodenum during diabetes and the noinvasive medical apparatus and instruments of jejunum sugar and fat intake.Bioadhesive drug delivery system fBio-adhesive Drug Delivery System, BDDS) refer to that medicine take adhering polymer and be carrier, biological agent by carrier, adhere to for a long time mucosa, and by the contact position mucous epithelium, enter blood circulation, the administering mode of performance part and general action.After the bioadhesion oral formulations sticks on stomach (intestinal) mucosa, when gastric is full of food and wriggles or gastric mucosa constantly update and to come off and gastric pH while changing, preparation can break away from gastric mucosa, by gastric emptying.And the floating in stomach adhesion preparation utilizes the fluid balance principle of dynamics, after the disengaging gastric mucosa, floatability, on the gastric content surface, is just advanced people's small intestinal with gastric emptying after 3h-4h, sticks on small bowel.The present invention utilizes the physicochemical property principle of bioadhesive drug delivery system, and filling the beta glucosan is content, and the sodium carboxymethyl cellulose of take is made capsule as coating.But this capsule oral administration use is easy to carry, easy to use, safe effective.
The invention provides a kind of volume little, not easy damaged coat of the stomach or esophagus, the capsule that can stop sugar and fat to absorb at Stomach duodenum and jejunum.
The technology of the present invention design: be coating by take the sodium carboxymethyl cellulose of bioadhesion administration principle, coated beta glucosan is content, make capsule, effectively reduce the absorption at Stomach duodenum and jejunum of sugar and fat, by the effect that reduces absorbance, carry out the restriction of energy and nutrient, reach the purpose of improving body weight, blood glucose and blood fat.
Beneficial effect of the present invention:
(1) of the present inventionly take the capsule coating of sodium carboxymethyl cellulose as raw material, compare the gelatine glaze of conventional capsule medicine, it can pass through the bioadhesion administering mode in gastric and small intestinal, namely at model of action such as gastric adhesion, floating in stomach, intestinal adhesions, stay in for more time gastrointestinal tract, the major function of this coating is to extend capsule 's content in gastrointestinal action time;
(2) the content material of beta glucosan of the present invention, be a kind of all can absorbed carbohydrate at Stomach duodenum and jejunum, can stop the absorption of nutrient during in gastrointestinal tract;
(3) beta glucosan of the present invention is after the harmonization of the stomach small intestinal stops, after the regular hour, can enter into large intestine by enterokinesia, and carry out being decomposed into short-chain fatty acid and vitamin K by probiotic bacteria at large enteral, for the wriggling of large intestine, the discharge of feces, positive effect is arranged.
The accompanying drawing explanation
Fig. 1 capsule overall schematic
Fig. 2 capsule acts on schematic diagram in intestinal
The specific embodiment
A kind of capsule that stops Nutrients Absorption at gastrointestinal tract, capsule are jointly to consist of sodium carboxymethyl cellulose capsule coat 1 parcel beta glucosan composition 2; Described sodium carboxymethyl cellulose capsule coat 1 discharges beta glucosan composition 2 through gastric juice effect digestion after entering gastric, sodium carboxymethyl cellulose capsule coat 1 forms floating thing at gastric, beta glucosan composition 2 can not absorb in gastric digestion, both enter intestinal with gastric emptying, and sodium carboxymethyl cellulose forms adhesive film 3 at the intestinal inwall; Described beta glucosan composition 2 can stop sugared, fatty etc. absorption.But the present invention's oral administration use, and discharge with feces.
Claims (1)
1. capsule that stops sugar and fat absorption at gastrointestinal tract, described capsule is by the common formation of sodium carboxymethyl cellulose capsule coat (1) parcel beta glucosan composition (2); It is characterized in that through gastric juice effect digestion, discharging beta glucosan composition (2) after described sodium carboxymethyl cellulose capsule coat (1) enters gastric, sodium carboxymethyl cellulose capsule coat (1) forms floating thing at gastric, beta glucosan composition (2) can not absorb in gastric digestion, both enter intestinal with gastric emptying, and sodium carboxymethyl cellulose forms adhesive film (3) at the intestinal inwall; Described beta glucosan composition (2) can stop sugared, fatty absorption.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013103853675A CN103405397A (en) | 2013-08-30 | 2013-08-30 | Capsule located in bioadhesive drug delivery manner for releasing beta glucosan |
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| CN2013103853675A CN103405397A (en) | 2013-08-30 | 2013-08-30 | Capsule located in bioadhesive drug delivery manner for releasing beta glucosan |
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| CN103405397A true CN103405397A (en) | 2013-11-27 |
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| CN2013103853675A Pending CN103405397A (en) | 2013-08-30 | 2013-08-30 | Capsule located in bioadhesive drug delivery manner for releasing beta glucosan |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113142596A (en) * | 2021-03-18 | 2021-07-23 | 广东工业大学 | Capsule for reducing food absorption |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1568940A (en) * | 2004-04-28 | 2005-01-26 | 复旦大学 | Preparation method of biont coherent particulates pharmaceutical preparation |
| WO2009144467A1 (en) * | 2008-05-29 | 2009-12-03 | Med-Eq As | Composition comprising 1, 3 /1, 6 beta glucan for reducing weight |
| CN102151304A (en) * | 2011-01-25 | 2011-08-17 | 四川省中医药科学院 | Gastric stasis system of total alkaloids of coptis and evodia rutaecarpa as well as preparation method and application thereof |
| CN102907606A (en) * | 2012-11-16 | 2013-02-06 | 西藏天麦力健康品有限公司 | Beta-glucan composition and application thereof |
-
2013
- 2013-08-30 CN CN2013103853675A patent/CN103405397A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1568940A (en) * | 2004-04-28 | 2005-01-26 | 复旦大学 | Preparation method of biont coherent particulates pharmaceutical preparation |
| WO2009144467A1 (en) * | 2008-05-29 | 2009-12-03 | Med-Eq As | Composition comprising 1, 3 /1, 6 beta glucan for reducing weight |
| CN102151304A (en) * | 2011-01-25 | 2011-08-17 | 四川省中医药科学院 | Gastric stasis system of total alkaloids of coptis and evodia rutaecarpa as well as preparation method and application thereof |
| CN102907606A (en) * | 2012-11-16 | 2013-02-06 | 西藏天麦力健康品有限公司 | Beta-glucan composition and application thereof |
Non-Patent Citations (2)
| Title |
|---|
| GUOJIE XU, ET AL: "Effect of FITC-dextran molecular weight on its release from floating cetyl alcohol and HPMC tablets", 《JOURNAL OF PHARMACY AND PHARMACOLOGY》, vol. 53, no. 1, 31 December 2001 (2001-12-31) * |
| MD. ISMAIL MOUZAM, ET AL: "Preparation of a novel floating ring capsule-type dosage form for stomach specific delivery", 《SAUDI PHARMACEUTICAL JOURNAL》, vol. 19, 18 January 2011 (2011-01-18), pages 85 - 93 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113142596A (en) * | 2021-03-18 | 2021-07-23 | 广东工业大学 | Capsule for reducing food absorption |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20131127 |