CN103393949A

CN103393949A - Traditional Chinese medicinal composition for treating chronic glomerulonephritis

Info

Publication number: CN103393949A
Application number: CN2013103450852A
Authority: CN
Inventors: 杜晓娅
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-08-04
Filing date: 2013-08-04
Publication date: 2013-11-20
Anticipated expiration: 2033-08-04
Also published as: CN103393949B

Abstract

The invention discloses a traditional Chinese medicinal composition for treating chronic glomerulonephritis. In Chinese medical science, chronic glomerulonephritis is thought to belong to the category of 'edema' disease, and is mainly caused by spleen and kidney deficiency, qi deficiency and blood stasis. Vital qi is deficient, blood stasis is converted into water, and pathogenic toxin is easy to invade, so that spleen and kidney are deficient for a long time and no longer recover, astringent therapy is invalid, and thus edema and proteinuria are refractory to eliminate. Therefore, traditional Chinese medicines of jasminum laurifolium, stephania tetrandra, salix hypoleuca, smooth stylose staff-tree, rhizoma corydalis, rust-colored crotalaria herb, dioscorea hemsleyi, radix boehmeriae, all-grass of redclawed habenaria, root of szechwan-Yunnan sanicle, and cypripedium margaritaceum franch are selected and decocted with water into a decoction. Through clinical tests, the total effective rate reaches 97.8%, and the treatment effect is significant.

Description

A kind of Chinese medicine composition for the treatment of chronic glomerulonephritis

Technical field

The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine composition for the treatment of chronic glomerulonephritis.

Background technology

Chronic glomerulonephritis claims that again chronic nephritis is a kind of autoimmune disease, the histological type complexity is various, its pathological lesion is main relevant with immune-mediated inflammatory reaction, consequently causes the glomerular sclerosis renal interstitial fibrosis, causes that the cause of disease of chronic nephritis is illustrated at present not yet fully.The clinical main manifestations of this disease is albuminuria, hematuria, edema, hypertension, anemia and the renal function injury of varying degree, the state of an illness is tediously long, and easily recurrence, if treatment not in time, can develop into chronic renal failure and threat to life, doctor trained in Western medicine also lacks desirable Therapeutic Method at present.The applicant proves through clinical trial for many years, utilize not only good effect of Chinese herbal treatment chronic glomerulonephritis, and side effect is little, and relapse rate is low.

Summary of the invention

The purpose of this invention is to provide a kind of Chinese medicine composition for the treatment of chronic glomerulonephritis.Motherland's medical science thinks that chronic glomerulonephritis belongs to " edema " sick category, how by due to asthenia of both the spleen and kidney, blood stasis due to qi deficiency.Positive QI-insufficiency, blood stasis water, evil poison is easily invaded, so that spleen kidney prolonged deficiency is multiple, astringency inducing is had no right, and cause edema, the urine protein stubbornness does not disappear.

The objective of the invention is to be achieved through the following technical solutions, the Chinese medicine composition of this treatment chronic glomerulonephritis is made by the Chinese medicine of following weight portion: Herba Jasmini laurifolii 40-50 part, Radix Cissi Kerrii 10-15 part, Radix Salicis Hypoleucae 9-13 part, Caulis Celastri glaberis 7-9 part, Rhizoma Corydalis 20-30 part, Herba Crotalariae Ferrugineae 13-18 part, Radix dioscoreae subcalvae 25-35 part, Radix Boehmeriae 19-26 part, Herba Habenariae rhodochellae 15-20 part, Radix Saniculae Astrantifoliae 8-17 part, Herba Cyperipedii Margaritacei 18-25 part.

Preferably, 45 parts of Herba Jasmini laurifoliis, 13 parts of Radix Cissi Kerrii, 11 parts of Radix Salicis Hypoleucae, 8 parts of Caulis Celastri glaberiss, 25 parts of Rhizoma Corydalis, 16 parts of Herba Crotalariae Ferrugineaes, 30 parts of Radix dioscoreae subcalvaes, 23 parts of Radix Boehmeriaes, 18 parts of Herba Habenariae rhodochellaes, 14 parts of Radix Saniculae Astrantifoliae, 22 parts of Herba Cyperipedii Margaritaceis.

Preparation method is made decoction with above-mentioned Chinese medicine decocting.

In side: Herba Jasmini laurifolii, Radix Cissi Kerrii heat-clearing and toxic substances removing, antiinflammatory diuresis, detumescence dissipating blood stasis, eliminating stagnation promoting the circulation of blood; Radix Salicis Hypoleucae, Caulis Celastri glaberis, Rhizoma Corydalis expelling wind and removing dampness, blood circulation promoting and blood stasis dispelling, Shujin, promoting the circulation of QI to relieve pain; Herba Crotalariae Ferrugineae, the Radix dioscoreae subcalvae gas of astringing the lung, spleen reinforcing kidney, diuresis, detumescence poison, invigorating the spleen to clear away damp pathogen; Herba Habenariae rhodochellae, Radix Saniculae Astrantifoliae, Herba Cyperipedii Margaritacei kidney invigorating and YANG supporting, invigorating the lung and the kidney, lively atmosphere blood; The Radix Boehmeriae clearing away heat and promoting diuresis.

Clinical data

1, selected of physical data group patient 138 examples derive from the court's Urology Department, male 82 examples wherein, female's 56 examples; Age＜10 year old 32 examples, 10～20 years old 26 example,＞21 years old 80 example; Minimum 7 years old of age, maximum 70 years old, average 36.5 years old; The course of disease is the longest 11 years, the shortest half a year., take the diagnostic criteria of the relevant chronic nephritis of the academic meeting of national nephropathy as foundation, be diagnosed as acute attack type 32 examples, plain edition 68 examples, hypertension 38 examples.

2, diagnostic criteria is with reference to the diagnostic criteria of the 2nd national academic conference revision of Nanjing China nephropathy association in 1985.(1) onset is slow, protracted inflammation, the time heavy when light, renal function is faded, anemia can appear in the later stage, electrolyte disturbance, the situations such as blood urea nitrogen, serum creatinine rising; (2) in various degree performances such as albuminuria, hematuria, edema and hypertension are arranged; (3) can bring out acute attack because of reasons such as respiratory tract infection in the state of an illness, the performance of similar acute nephritis occur, also have some cases that the automatic catabasis can be arranged.

3, this group of Therapeutic Method patient takes Chinese medicine composition of the present invention, namely take Herba Jasmini laurifolii 45g, Radix Cissi Kerrii 13g, Radix Salicis Hypoleucae 11g, Caulis Celastri glaberis 8g, Rhizoma Corydalis 25g, Herba Crotalariae Ferrugineae 16g, Radix dioscoreae subcalvae 30g, Radix Boehmeriae 23g, Herba Habenariae rhodochellae 18g, Radix Saniculae Astrantifoliae 14g, Herba Cyperipedii Margaritacei 22g, decocting becomes decoction, every day potion, divide morning, late secondary to take, 15 days is a course for the treatment of.

4, criterion of therapeutical effect reference " (the new Chinese medicine guideline of clinical investigations ", (1) alleviate fully: symptom and sign disappear fully, normal renal function, and 24h urine protein quantitation＜0.20g or urine protein examination continue negative, under high power lens, urine erythrocyte disappears, and the Urine sediments analyzer counting is normal; (2) the basic alleviation: symptom and sign disappear substantially, normal renal function, and the urine protein examination continuous decrease is more than 50%, and under high power lens, urine erythrocyte is no more than 3, and the Urine sediments analyzer counting approaches normal; (3) take a turn for the better: symptom and sign are clearly better, and renal function is normal or be improved, and 24h urine protein quantitation continuous decrease is more than 25%, and urine protein continues 1 "+", and under high power lens, urine erythrocyte is no more than 5; (4) invalid: clinical manifestation and above-mentioned lab testing are all without obviously improving or increasing the weight of.

5, this group of therapeutic outcome patient 138 example treatments are added up curative effect after three courses for the treatment of, wherein alleviate 112 examples (81.2) fully; Basic alleviation 14 (10.1); Effective 9 examples (6.5); Invalid 3 examples (2.2); Total effective rate 97.8%.

The specific embodiment

Embodiment one: take Herba Jasmini laurifolii 45g, Radix Cissi Kerrii 13g, Radix Salicis Hypoleucae 11g, Caulis Celastri glaberis 8g, Rhizoma Corydalis 25g, Herba Crotalariae Ferrugineae 16g, Radix dioscoreae subcalvae 30g, Radix Boehmeriae 23g, Herba Habenariae rhodochellae 18g, Radix Saniculae Astrantifoliae 14g, Herba Cyperipedii Margaritacei 22g, decocting becomes decoction.

Embodiment two: take Herba Jasmini laurifolii 50g, Radix Cissi Kerrii 15g, Radix Salicis Hypoleucae 9g, Caulis Celastri glaberis 7g, Rhizoma Corydalis 20g, Herba Crotalariae Ferrugineae 18g, Radix dioscoreae subcalvae 35g, Radix Boehmeriae 26g, Herba Habenariae rhodochellae 15g, Radix Saniculae Astrantifoliae 17g, Herba Cyperipedii Margaritacei 25g, decocting becomes decoction.

Embodiment three: take Herba Jasmini laurifolii 40g, Radix Cissi Kerrii 10g, Radix Salicis Hypoleucae 13g, Caulis Celastri glaberis 9g, Rhizoma Corydalis 30g, Herba Crotalariae Ferrugineae 13g, Radix dioscoreae subcalvae 25g, Radix Boehmeriae 19g, Herba Habenariae rhodochellae 20g, Radix Saniculae Astrantifoliae 8g, Herba Cyperipedii Margaritacei 18g, decocting becomes decoction.

Claims

1. Chinese medicine composition for the treatment of chronic glomerulonephritis, is characterized in that this Chinese medicine composition made by the Chinese medicine of following weight portion: Herba Jasmini laurifolii 40-50 part, Radix Cissi Kerrii 10-15 part, Radix Salicis Hypoleucae 9-13 part, Caulis Celastri glaberis 7-9 part, Rhizoma Corydalis 20-30 part, Herba Crotalariae Ferrugineae 13-18 part, Radix dioscoreae subcalvae 25-35 part, Radix Boehmeriae 19-26 part, Herba Habenariae rhodochellae 15-20 part, Radix Saniculae Astrantifoliae 8-17 part, Herba Cyperipedii Margaritacei 18-25 part.

2. a kind of Chinese medicine composition for the treatment of chronic glomerulonephritis according to claim 1, is characterized in that this Chinese medicine composition made by the Chinese medicine of following weight portion: 45 parts of Herba Jasmini laurifoliis, 13 parts of Radix Cissi Kerrii, 11 parts of Radix Salicis Hypoleucae, 8 parts of Caulis Celastri glaberiss, 25 parts of Rhizoma Corydalis, 16 parts of Herba Crotalariae Ferrugineaes, 30 parts of Radix dioscoreae subcalvaes, 23 parts of Radix Boehmeriaes, 18 parts of Herba Habenariae rhodochellaes, 14 parts of Radix Saniculae Astrantifoliae, 22 parts of Herba Cyperipedii Margaritaceis.