CN103393935B - Traditional Chinese medicine preparation for treating chronic nephritis - Google Patents
Traditional Chinese medicine preparation for treating chronic nephritis Download PDFInfo
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- CN103393935B CN103393935B CN201310345065.5A CN201310345065A CN103393935B CN 103393935 B CN103393935 B CN 103393935B CN 201310345065 A CN201310345065 A CN 201310345065A CN 103393935 B CN103393935 B CN 103393935B
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- rhizoma
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- chronic nephritis
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- 239000003814 drug Substances 0.000 title claims abstract description 19
- 206010018367 Glomerulonephritis chronic Diseases 0.000 title claims abstract description 12
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 210000003734 kidney Anatomy 0.000 abstract description 7
- 206010030113 Oedema Diseases 0.000 abstract description 5
- 239000008280 blood Substances 0.000 abstract description 5
- 210000004369 blood Anatomy 0.000 abstract description 5
- 208000024891 symptom Diseases 0.000 abstract description 5
- 230000007812 deficiency Effects 0.000 abstract description 4
- 201000010099 disease Diseases 0.000 abstract description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 4
- 208000006750 hematuria Diseases 0.000 abstract description 4
- 210000000952 spleen Anatomy 0.000 abstract description 4
- 210000004072 lung Anatomy 0.000 abstract description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 3
- 208000008035 Back Pain Diseases 0.000 abstract description 2
- 208000008930 Low Back Pain Diseases 0.000 abstract description 2
- 230000000694 effects Effects 0.000 abstract description 2
- 230000002950 deficient Effects 0.000 abstract 2
- 240000008917 Glycyrrhiza uralensis Species 0.000 abstract 1
- 235000000554 Glycyrrhiza uralensis Nutrition 0.000 abstract 1
- 235000002710 Ilex cornuta Nutrition 0.000 abstract 1
- 241001310146 Ilex cornuta Species 0.000 abstract 1
- 241001442158 Myosotis sylvatica Species 0.000 abstract 1
- 241001340772 Rhododendron microphyton Species 0.000 abstract 1
- 241001121987 Scrophularia ningpoensis Species 0.000 abstract 1
- 241000208968 Securidaca Species 0.000 abstract 1
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 1
- 208000004880 Polyuria Diseases 0.000 description 3
- 230000035619 diuresis Effects 0.000 description 3
- 231100000614 poison Toxicity 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 239000003440 toxic substance Substances 0.000 description 3
- 206010001580 Albuminuria Diseases 0.000 description 2
- 206010020772 Hypertension Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 206010023421 Kidney fibrosis Diseases 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 208000007502 anemia Diseases 0.000 description 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
- 206010061989 glomerulosclerosis Diseases 0.000 description 2
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- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 241001530126 Scrophularia Species 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- PNNCWTXUWKENPE-UHFFFAOYSA-N [N].NC(N)=O Chemical compound [N].NC(N)=O PNNCWTXUWKENPE-UHFFFAOYSA-N 0.000 description 1
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- 230000017531 blood circulation Effects 0.000 description 1
- 208000020832 chronic kidney disease Diseases 0.000 description 1
- 208000022831 chronic renal failure syndrome Diseases 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
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- 238000004519 manufacturing process Methods 0.000 description 1
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating chronic nephritis. Chronic nephritis belongs to the categories of traditional Chinese medicine edema, consumptive disease, lumbago, hematuria and the like, and belongs to the symptom of deficient root and excessive superficial, wherein deficient root refers to deficiency of three dirties of lung, spleen and kidney and mainly refers to deficiency of both kidney qi and yin, and excessive superficial refers to external evil, water dampness, damp heat, blood stasis and the like. Therefore, traditional Chinese medicines of myosotis sylvatica, rhizoma alismatis, rhizoma panasis japonici, securidaca inappendiculata hassk, scrophularia ningpoensis, rhizoma atractylodis, rhizoma polygonati, ilex cornuta lindl, fructus schisandrae lancifoliae, rhododendron microphyton franch, and glycyrrhiza uralensis are selected and decocted with water to obtain a decoction. Through clinical trials in a hospital, the total effective rate reaches 94.6%, and the curative effect is superior to control groups.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine preparation for the treatment of chronic nephritis.
Background technology
Chronic nephritis is Urology Department commonly encountered diseases, is a kind of autoimmune disease, and histological type complexity is various, and its pathological lesion is main relevant with immune-mediated inflammatory reaction, consequently causes glomerular sclerosis renal interstitial fibrosis.Though causing the cause of disease of chronic nephritis does not illustrate completely, common with the blue or green middle age, clinical main manifestations is edema, hematuria, albuminuria, hypertension, anemia and renal dysfunction in various degree, the state of an illness is tediously long, and easily recurrence, if treatment not in time, can develop into chronic renal failure and threat to life.Recent study shows that a lot of Chinese medicine can or reduce the expression of these inflammatory factors by blocking part inflammatory factor, correct the unbalance immunologic injury causing of cytokine network, suppress glomerular sclerosis and renal interstitial fibrosis, form thereby reduce immune complex, alleviate glomerule infringement.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine preparation for the treatment of chronic nephritis.Chronic nephritis belongs to the categories such as the edema, asthenia, lumbago, hematuria of the traditional Chinese medical science, belongs to the card of deficiency in origin and excess in superficiality, and deficiency in origin refers to the virtual loss that lung spleen kidney three is dirty, and taking kidney qi Yin bivacuity as main, and mark is real refers to that exopathogen, water are wet, damp and hot, blood stasis etc.
The object of the invention is to be achieved through the following technical solutions, the Chinese medicine preparation of this treatment chronic nephritis is made up of the Chinese medicine of following weight portion: Radix limonii sinensis 13-17 part, Rhizoma Alismatis 15-20 part, Rhizoma Tupistrae ensifoliae 9-13 part, Radix securidacae 20-28 part, Radix Scrophulariae 7-12 part, Rhizoma Atractylodis Macrocephalae 12-15 part, Rhizoma Polygonati 17-22 part, Radix Ilicis Cornutae 18-30 part, Fructus Schisandrae lancifoliae 11-17 part, Radix Rhododendri 40-50 part, Radix Glycyrrhizae 3-4 part.
Preferably, 15 parts of Radix limonii sinensis, 18 parts of Rhizoma Alismatis, 11 parts of Rhizoma Tupistrae ensifoliaes, 25 parts of Radix securidacae, 10 parts of Radix Scrophulariaes, 9 parts of the Rhizoma Atractylodis Macrocephalaes, 19 parts of Rhizoma Polygonatis, 24 parts of Radix Ilicis Cornutaes, 14 parts of Fructus Schisandrae lancifoliaes, 45 parts of Radix Rhododendris, 3.5 parts, Radix Glycyrrhizae.
Above-mentioned Chinese medicine decocting is made decoction by preparation method.
Fang Zhong: Radix limonii sinensis, Rhizoma Alismatis damp eliminating heat clearing away, hemostasis, promoting diuresis to eliminate damp pathogen, expels the heat-evil; Rhizoma Tupistrae ensifoliae, Radix securidacae, Radix Rhododendri heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, inducing diuresis to remove edema, clearing away heat and promoting diuresis; Radix Scrophulariae clearing away heat and cooling blood, YIN nourishing removing toxic substances; The Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati air making-up and spleen enlivening, dampness diuretic, nourishing kidney lung moistening, invigorating the spleen and replenishing QI; Radix Ilicis Cornutae, Fructus Schisandrae lancifoliae invigorating the liver and kidney, fresh breeze heat, beneficial essence is reinforced the kidney; The invigorating middle warmer of Radix Glycyrrhizae QI invigorating, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, alleviates pain relieving.
Clinical data
1, physical data select in February, 2006～2010 year October I institute be in hospital and outpatient service patients with chronic glomerulonephritis 100 examples, be divided at random two groups: treatment group 56 examples, male 30 examples, female's 26 examples, 20～60 years old age; Matched group 44 examples, male 24 examples, female's 20 examples, 22～65 years old age.The equal not statistically significants of difference (P < 0.05) such as two groups of sexes, age, the course of disease, have comparability.
2, diagnostic criteria is with reference to the diagnostic criteria of the 2nd national academic conference revision of Nanjing nephropathy association of China in 1985.(1) onset is slow, protracted inflammation, time heavy when light, renal function is faded, can there is anemia in the later stage, electrolyte disturbance, the situations such as blood urea nitrogen, serum creatinine rising.(2) there are the performances such as albuminuria, hematuria, edema and hypertension in various degree.(3) in the state of an illness, can bring out acute attack because of reasons such as respiratory tract infection, occur the performance of similar acute nephritis, also have some cases can have the automatic catabasis.
4, Therapeutic Method treatment group patient takes Chinese medicine preparation of the present invention, take Radix limonii sinensis 15g, Rhizoma Alismatis 18g, Rhizoma Tupistrae ensifoliae 11g, Radix securidacae 25g, Radix Scrophulariae 10g, Rhizoma Atractylodis Macrocephalae 9g, Rhizoma Polygonati 19g, Radix Ilicis Cornutae 24g, Fructus Schisandrae lancifoliae 14g, Radix Rhododendri 45g, Radix Glycyrrhizae 3.5g, decocting becomes decoction, every day, potion, divided a secondary to take; Matched group patient takes 3 tablets/time of zhiling capsuleses, day 3 times oral (production of Datong Li Qun Pharmaceutical Co., Ltd).Two groups equal 15 days is a course for the treatment of.
5, criterion of therapeutical effect is treated 3 courses for the treatment of, according to Western medicine diagnose foundation, carries out Clinical efficacy comparison: (1) cures: clinical symptom disappearance, laboratory checking index normal; (2) effective: clinical symptoms is clearly better, laboratory checking index is clearly better; (3) take a turn for the better: clinical symptoms takes a turn for the better, laboratory checking index takes a turn for the better; (4) invalid: clinical symptoms, lab index are all without improving.
6, curative effect comparison after three courses for the treatment of of two groups of therapeutic outcomes treatment, treatment group 56 examples, wherein cure 39 examples (69.6), effective 9 examples (16.1), 5 examples that take a turn for the better (8.9), invalid 3 examples (5.4) total effective rate 94.6%; Matched group 44 examples, wherein cure 11 examples (25.0), effective 15 examples (34.1), 10 examples that take a turn for the better (22.7), invalid 8 examples (18.2), total effective rate 81.8%.Two groups are compared treatment group cure rate, total effective rate, are obviously better than matched group, and P < 0.05 has comparability.
Detailed description of the invention
Embodiment mono-: take Radix limonii sinensis 15g, Rhizoma Alismatis 18g, Rhizoma Tupistrae ensifoliae 11g, Radix securidacae 25g, Radix Scrophulariae 10g, Rhizoma Atractylodis Macrocephalae 9g, Rhizoma Polygonati 19g, Radix Ilicis Cornutae 24g, Fructus Schisandrae lancifoliae 14g, Radix Rhododendri 45g, Radix Glycyrrhizae 3.5g, above-mentioned Chinese medicine decocting is become to decoction.
Embodiment bis-: take Radix limonii sinensis 17g, Rhizoma Alismatis 20g, Rhizoma Tupistrae ensifoliae 13g, Radix securidacae 28g, Radix Scrophulariae 12g, Rhizoma Atractylodis Macrocephalae 15g, Rhizoma Polygonati 17g, Radix Ilicis Cornutae 30g, Fructus Schisandrae lancifoliae 11g, Radix Rhododendri 50g, Radix Glycyrrhizae 4g, above-mentioned Chinese medicine decocting is become to decoction.
Embodiment tri-: take Radix limonii sinensis 13g, Rhizoma Alismatis 15g, Rhizoma Tupistrae ensifoliae 9g, Radix securidacae 20g, Radix Scrophulariae 7g, Rhizoma Atractylodis Macrocephalae 12g, Rhizoma Polygonati 22g, Radix Ilicis Cornutae 18g, Fructus Schisandrae lancifoliae 17g, Radix Rhododendri 40g, Radix Glycyrrhizae 3g, above-mentioned Chinese medicine decocting is become to decoction.
Claims (1)
1. treat a Chinese medicine preparation for chronic nephritis, it is characterized in that this Chinese medicine preparation is made up of the Chinese medicine of following weight: Radix limonii sinensis 15g, Rhizoma Alismatis 18g, Rhizoma Tupistrae ensifoliae 11g, Radix securidacae 25g, Radix Scrophulariae 10g, Rhizoma Atractylodis Macrocephalae 9g, Rhizoma Polygonati 19g, Radix Ilicis Cornutae 24g, Fructus Schisandrae lancifoliae 14g, Radix Rhododendri 45g, Radix Glycyrrhizae 3.5g.
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| CN104001025A (en) * | 2014-06-13 | 2014-08-27 | 冯增光 | Traditional Chinese medicine for treating chronic nephritis qi and yin deficiency and damp-heat syndrome and preparation method thereof |
| CN106138239A (en) * | 2016-07-30 | 2016-11-23 | 庄炎 | A kind of Chinese medicine preparation treating chronic glomerulonephritis |
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| CN1178694A (en) * | 1997-07-10 | 1998-04-15 | 迟经惠 | Medicine for curing uraemia |
| CN102451305A (en) * | 2010-10-27 | 2012-05-16 | 赵传利 | Chinese medicinal formula for treating chronic pyelonephritis |
| CN102813815B (en) * | 2012-07-31 | 2013-10-23 | 王萍 | Traditional Chinese medicine composition for treating chronic pyelitis |
| CN102793902B (en) * | 2012-08-03 | 2013-10-02 | 王淑玲 | Preparation method for traditional Chinese medicine used for treatment of kidney and yin deficient type acute glomerulonephritis |
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