CN105435018A - Traditional Chinese medicine preparation for treating gout and preparation method thereof - Google Patents

Traditional Chinese medicine preparation for treating gout and preparation method thereof Download PDF

Info

Publication number
CN105435018A
CN105435018A CN201511004699.XA CN201511004699A CN105435018A CN 105435018 A CN105435018 A CN 105435018A CN 201511004699 A CN201511004699 A CN 201511004699A CN 105435018 A CN105435018 A CN 105435018A
Authority
CN
China
Prior art keywords
parts
herba
chinese medicine
medicine preparation
gout
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201511004699.XA
Other languages
Chinese (zh)
Inventor
张利
尹丽丽
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201511004699.XA priority Critical patent/CN105435018A/en
Publication of CN105435018A publication Critical patent/CN105435018A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/90Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13Coniferophyta (gymnosperms)
    • A61K36/14Cupressaceae (Cypress family), e.g. juniper or cypress
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/26Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/264Aristolochia (Dutchman's pipe)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/26Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/268Asarum (wild ginger)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282Artemisia, e.g. wormwood or sagebrush
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/31Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/58Meliaceae (Chinaberry or Mahogany family), e.g. Azadirachta (neem)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/61Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/74Rubiaceae (Madder family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The invention discloses a traditional Chinese medicine preparation for treating gout and a preparation method thereof, and belongs to the field of traditional Chinese medicines. The effective ingredient of the traditional Chinese medicine preparation is prepared from the following raw materials: chinaroot greenbrier, needle juniper, Chinese alpine rush, campsis grandiflora loisel, Chinese white birch sap, angelica pubescens, toona sinensis seeds, Indian rorippa herb, artemisia capillaris, murdannia triquetra, angelica citriodora hance, aristolochia moupinensis franch, Japanese buttercup herb, asarum, Chinese ixora flowers and folium eucalypti. The traditional Chinese medicine preparation is prepared from compatible medicinal materials, accords with traditional Chinese medicine and modern medicine theories, has the effects of expelling wind, diminishing swelling, alleviating pain, promoting blood circulation to relieve pain and easing joint movement. The traditional Chinese medicine preparation is convenient to use, has a good absorption effect and no negative, toxic or side effect. Clinical application verifies that the preparation can be used for remarkably reducing the blood uric acid, has an extremely good effect for preventing and treating gout, and is applicable to prevention and treatment of gout.

Description

A kind of Chinese medicine preparation and preparation method being used for the treatment of gout
Art
The present invention relates to the field of Chinese medicines, particularly relate to a kind of Chinese medicine preparation and the preparation method that are used for the treatment of gout.
Background technology
Gout is the crystal dependency arthrosis caused by monosodium urate mineralization, directly related with the hyperuricemia caused by purine metabolic disturbance and (or) underexcretion, refers in particular to acute characteristic arthritis and chronic gout stone disease.
Gout clinical manifestation is as follows:
1. acute gouty arthritis: without obvious sign before most of patients outbreak, or only have tired, general malaise and joint sting etc.Typical onset is often waken up with a start the late into the night because of arthralgia, and pain Progressive symmetric erythrokeratodermia aggravates.First-episode many infringements simple joint, part is above occurs in Metatarsophalangeal joint, and in the course of disease afterwards, some patients involves this position.Secondly be the joints such as instep, heel, ankle, knee joint, wrist and elbow, getting involved less in the joints such as shoulder, hip, spinal column and temporo jaw, can involve multiple joint simultaneously, show as polyarthritis.
2. interval stage of attack: can spontaneous remission after gout outbreak last from days to several weeks, generally without obvious sequela shape, or leave over localised skin pigmentation, desquamation and scratchy etc., enter the asymptomatic intermission later, recur after lasting several months, several years or more than ten years.
3. the chronic gout stone pathological changes phase: subcutaneous tophus and chronic gout stone arthritis are long-term significant hyperuricemias.The typical parts that subcutaneous tophus occurs is auricle.Outward appearance is the yellow-white vegetation not of uniform size of subcutaneous protuberance, and skin surface is belittled, and discharges white powder or pastel after ulceration.。Clinical manifestation is for continuing arthralgia, tenderness, deformity and dysfunction.Chronic phase, symptom relaxed relatively, but also can have acute attack.
4. nephropathy: (1) chronic urate nephropathy urate crystals is deposited on renal interstitial, causes chronic renal tubule one interstitial nephritis.Clinical manifestation is that urine concentrating power declines, occur that nocturia increases, low-gravity urine, small molecular protein urine, leukocyturia, slightly hematuria and cylinderuria etc.(2) uric acid lithangiuria urine uric acid concentration increases in hypersaturated state, deposits and form calculus in urinary system.(3) acute urate nephropathy blood and the hurried rising of urine uric acid level, a large amount of uric acid crystal is deposited on the place such as renal tubules, collecting tubule, causes acute urinary tract obstruction.Clinical manifestation is oliguria, anuria, acute renal failure; Visible a large amount of uric acid crystal in urine.
If gout is not diagnosed early and carried out Canonical management, detection of glomeruli filtration function can be caused and decline, occur renal insufficiency, even threat to life.For gout, patient with gout usually not only will be careful in one's diet health, also want bound drug to treat and make serum uric acid level control up to standard, and Chinese medicine has advantages such as effect is strong, instant effect, lasting medicine, and there is no dependency, drug resistance and toxic and side effects, therefore select a kind of Chinese medicine preparation to be used for the treatment of gout, for treatment gout, there is very important clinical meaning.
Summary of the invention
The invention provides a kind of Chinese medicine preparation and the preparation method that are used for the treatment of gout, selected by Chinese medicine preparation of the present invention, medical material compatibility is suitable, meet Chinese medicine and modern medicine theoretical, there is detumescence of dispeling the wind, analgesia of dispeling the wind, promoting blood circulation and stopping pain, the sharp joint of clearance effect, easy to use, good absorbing effect, without bad and toxic and side effects, through clinical verification, obviously Level of Serum Uric Acid can be reduced, there are fabulous prevention and therapeutic effect to gout, are suitable for prevention and the treatment of gout.
For achieving the above object, technical scheme of the present invention is implemented as follows:
Be used for the treatment of a Chinese medicine preparation for gout, raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Be used for the treatment of a preparation method for the Chinese medicine preparation of gout, comprise following processing step:
(1) Rhizoma Smilacis Chinensis, Radix campsis, Radix Angelicae Pubescentis, Radix osterici citriodori (Radix Angelicae Citriodorae) and Caulis aristolochiae moupinensis are removed impurity, clear water is unrestrained to be washed, and run through, take out section, Exposure to Sunlight is dried, and is placed in mortar and grinds into powder, must be 120 object fine powders, for subsequent use;
(2) Juniperus rigida Sieb.et Zucc., Fructus Tonnae Sinensis, Herba Artemisiae Scopariae, Herba Ranunculi Japonici and Folium eucalypti globueli (Eucalyptus globulus Labill.) are removed impurity, clean, put into container, add 5 times amount distilled water, decoct 2 hours, extract decoction liquor; Add 3 ~ 4 times amount distilled water again, decoct 1.5 hours, extract decoction liquor, finally merge the decoction liquor extracted for 2 times, filter, obtain filtrate, then add wherein by Sucus Betulae platyphyllae, being condensed into relative density at 60 DEG C is the thick paste of 1.10 ~ 1.13, for subsequent use;
(3) Herba Poae Sphondylodis, Herba Murdanniae Triquetrae and Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) are removed impurity, clean, be placed in pot and fry to tack-free, taking-up is dried, and is placed in mortar and grinds into powder, must be 140 object fine powders, for subsequent use;
(4) Herba Rorippae and Herba Asari are removed impurity, clean, cutting, sun dehydration, is placed in mortar and grinds into powder, must be 160 object fine powders, for subsequent use;
(5) make tablet after being mixed with the thick paste of step (2) gained by the fine powder of step (1), step (3), step (4) gained, be the described Chinese medicine preparation being used for the treatment of gout.
The property of medicine of the present invention's Chinese medicine used is as follows:
Rhizoma Smilacis Chinensis: sweet in the mouth, acid, property is put down.Wind-damp dispelling, diuresis, detumescence poison.For arthralgia, muscle is numb, dysentery, edema gonorrhea, furuncle swelling toxin, scrofula hemorrhoid." medical center bun will " carries: " the hard kidney of slow liver, clear small intestine fire, changes bladder water.Control malignant boil, skin infection, insect poison.”
Juniperus rigida Sieb.et Zucc.: sweet in the mouth, hardship, property is put down.To dispel the wind analgesia, dehumidifying diuresis.For rheumatic arthritis, gout nephritis, edema, urinary tract infection.
Herba Poae Sphondylodis: lightly seasoned, cold in nature.Inducing diuresis for treating stranguria syndrome, expels the heat-evil and calms the nerves.For hot urination, pyretic stranguria, oedema due to nephritis, dizzy toothache, epistaxis pharyngalgia, vexed insomnia, quenches one's thirst, nocturnal emission." Anhui medical material " carries: " dampness removing heat, loose wind-fire, hemostasis.Control gout, epistaxis, metrorrhagia, frequent micturition short red, pharyngalgia, otalgia, nocturnal emission.”
Radix campsis: sweet in the mouth, pungent, cold in nature; Return liver,spleen,kidney warp.Cooling blood, expelling wind, promoting blood circulation to remove obstruction in the collateral.For blood hot air wind producing, itching over the body rubella, waist foot is unsuccessful, gout, rheumatism numbness, traumatic injury." Japan hanako materia medica " carries: " control hot blast itching over the body, urticaria, rubella, blood stasis, leukorrhagia.”
Sucus Betulae platyphyllae: bitter in the mouth, cool in nature.Expelling phlegm for arresting cough, heat-clearing and toxic substances removing.For cough and asthma, hot urination." Chinese herbal medicine handbook is commonly used in Heilungkiang " carries: " control vitamin C deficiency, nephropathy, gout.There is antipyretic and antidote functions.”
Radix Angelicae Pubescentis: acrid in the mouth, hardship, slightly warm in nature; Return kidney, urinary bladder channel.Expelling wind and removing dampness, numbness relieving and pain relieving.For anemofrigid-damp arthralgia, lumbocrural pain, few cloudy volt wind headache." not Lu " carries: " control all wind, hundred arthralgia wind are without new person for a long time.”
Fructus Tonnae Sinensis: acrid in the mouth, hardship, warm in nature; Return liver, lung meridian.Dispel the wind, cold expelling, pain relieving.For wind and cold diseases caused by exogenous pathogenic factor, heart peratodynia, Fengshi Guanjie pain, hernia." Traditional Chinese Medicine in Sichuan will " carries: " except wind and cold, control cold GUFENG and rheumatic arthritis.”
Herba Rorippae: sweet in the mouth, light, cool in nature.Heat-clearing and toxic substances removing, antitussive diuresis.For cold, fever, laryngopharynx swelling and pain, cough due to lung-heat, acute rheumatic arthritis, dysuria, venom, furuncle carbuncle." conventional Chinese herbal medicine handbook " carries: " clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.Cure cold heating, laryngopharynx swelling and pain, aphonia; Cough due to lung-heat, hemoptysis; Acute rheumatic arthritis; Edema.”
Herba Artemisiae Scopariae: bitter in the mouth, pungent, cool in nature, returns liver, spleen, urinary bladder channel.Clearing away heat-damp and promoting diuresis.For jaundice due to damp-heat, dysuria, pruritus due to wind pathogen skin ulcer scabies." book on Chinese herbal medicine is new again " carries: " pathogenic fire purging, suppressing the hyperactive liver reduce phlegm, cough-relieving diaphoresis, dampness removing, detumescence, treat all poison of skin ulcer fire.”
Herba Murdanniae Triquetrae: sweet in the mouth, cold in nature; Return lung, urinary bladder channel.Clearing away heat and promoting diuresis, subduing swelling and detoxicating.For dyspnea and cough due to lung-heat, red white dysentery, dysuria, laryngopharynx swelling and pain, carbuncle furuncle furuncle swells." Fujian traditional herbal medicine " carries: " diuresis, purges heat, detumescence, removing toxic substances.”
Radix osterici citriodori (Radix Angelicae Citriodorae): acrid in the mouth, hardship, slightly warm in nature.Wind and heat dispersing, promoting blood circulation to remove blood stasis, promoting the circulation of QI to relieve pain.For cough due to pathogenic wind-heat, angina pectoris, stomachache, malarial dysentery, amenorrhea leucorrhea, traumatic injury." the practical Chinese herbal medicine in Guangxi newly selects " carries: " root: wind dispelling is subsided a swelling, promoting blood circulation to remove blood stasis, activating QI pain relieving.Cure mainly stomachache, spitting of blood, rheumatic arthralgia, cold pus infections, chronic osteomyelitis, stomachache.”
Caulis aristolochiae moupinensis: bitter in the mouth, cold in nature; GUIXIN, kidney, bladder, small intestine meridian.Clearing away heat-damp and promoting diuresis, row is breast under water, evacuation of pus pain relieving.For dysuria, edema, urinary tract infection, trichomonas vaginitis, rheumatic arthritis, eczema, urticaria, carbuncle." Yunnan Chinese herbal medicine " carries: " removing damp-heat, evacuation of pus pain relieving.Control damp and hot dysuria, hematuria, trichomonas vaginitis, eczema, urticaria, rheumatic arthritis.”
Herba Ranunculi Japonici: acrid in the mouth, micro-hardship, warm in nature, poisonous.Inducing diuresis and reducing edema, pain relieving nebula removing.For malaria jaundice, migraine, stomachache, rheumatic arthritis, the arthroncus of knee, carbuncle malignant boil, scabies is had a toothache." book on Chinese herbal medicine pushes away old " carries: " external is dermerethistica.Control scrofula, arthritis, tuberculosis of joint, bone tuberculosis, bronchus is panted, and the routed person of all carbuncle of yin nature toxic swellings.”
Herba Asari: acrid in the mouth, warm in nature; GUIXIN, lung, kidney channel.Expelling wind and cold, understand things pain-stopping, warming the lung to resolve fluid-retention.For anemofrigid cold, headache toothache, nasal obstruction nasal sinusitis, rheumatic arthralgia, phlegm retention is breathed with cough." herbal classic " carries: " main cough with dyspnea, headache brain moves, hundred joint contractures, rheumatic arthralgia, dead flesh.Improving eyesight, sharp nine orifices.”
Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati): bitter in the mouth, micro-puckery, cool in nature.Dissipating blood stasis stops blooding, regulating menstruation blood pressure lowering.For hemoptysis of pulmonary tuberculosis, stomachache, rheumatic arthritis, traumatic injury, menoxenia, amenorrhea, hypertension." the SHENGCAO property of medicine standby will " carries: " disappear skin ulcer, and pus of tut-tuting, dispels the wind, pain relieving, reason phlegm-fire.”
Folium eucalypti globueli (Eucalyptus globulus Labill.): bitter in the mouth, pungent, cool in nature; Return lung, stomach, spleen, Liver Channel.Dispelling wind to relieve the exterior syndrome, heat-clearing and toxic substances removing, phlegm-eliminiating and qi-regulating, killing parasites for relieving itching.For flu, high dyspnea of heat type is coughed, pertussis, abdominal distention, diarrhoea, rheumatalgia, eczema scabies, burn and scald, traumatic hemorrhage.
The present invention compared with prior art, has following beneficial effect:
Selected by Chinese medicine preparation of the present invention, medical material compatibility is suitable, meet Chinese medicine and modern medicine theory, there is detumescence of dispeling the wind, analgesia of dispeling the wind, promoting blood circulation and stopping pain, clearance profit joint effect, easy to use, good absorbing effect, without bad and toxic and side effects, through clinical verification, obviously can reduce Level of Serum Uric Acid, have fabulous prevention and therapeutic effect to gout, be suitable for prevention and the treatment of gout.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
The processing step of Chinese medicine preparation preparation method of the present invention is:
(1) Rhizoma Smilacis Chinensis, Radix campsis, Radix Angelicae Pubescentis, Radix osterici citriodori (Radix Angelicae Citriodorae) and Caulis aristolochiae moupinensis are removed impurity, clear water is unrestrained to be washed, and run through, take out section, Exposure to Sunlight is dried, and is placed in mortar and grinds into powder, must be 120 object fine powders, for subsequent use;
(2) Juniperus rigida Sieb.et Zucc., Fructus Tonnae Sinensis, Herba Artemisiae Scopariae, Herba Ranunculi Japonici and Folium eucalypti globueli (Eucalyptus globulus Labill.) are removed impurity, clean, put into container, add 5 times amount distilled water, decoct 2 hours, extract decoction liquor; Add 3 ~ 4 times amount distilled water again, decoct 1.5 hours, extract decoction liquor, finally merge the decoction liquor extracted for 2 times, filter, obtain filtrate, then add wherein by Sucus Betulae platyphyllae, being condensed into relative density at 60 DEG C is the thick paste of 1.10 ~ 1.13, for subsequent use;
(3) Herba Poae Sphondylodis, Herba Murdanniae Triquetrae and Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) are removed impurity, clean, be placed in pot and fry to tack-free, taking-up is dried, and is placed in mortar and grinds into powder, must be 140 object fine powders, for subsequent use;
(4) Herba Rorippae and Herba Asari are removed impurity, clean, cutting, sun dehydration, is placed in mortar and grinds into powder, must be 160 object fine powders, for subsequent use;
(5) make tablet after being mixed with the thick paste of step (2) gained by the fine powder of step (1), step (3), step (4) gained, be the described Chinese medicine preparation being used for the treatment of gout.
Usage and dosage: oral, every day 3 times, takes for 1 hour after meal, and the morning, noon and afternoon, respectively once each 2, every sheet 30mg 20 days was a course for the treatment of, usual recovery from illness 1 ~ 4 course for the treatment of, and severe patient is followed the doctor's advice the meal with wine amount of adding.Embodiment 2
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 3
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 4
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Clinical data:
1, case selection:
Select the routine clinical observation of patient with gout 480 that my institute or outer court make a definite diagnosis, patient is divided into two groups at random, treatment group 240 example, wherein male 180 example, women 60 example, 33 ~ 64 years old age, 50 years old mean age, the course of disease 1 year ~ 4 years, average 3 years.Matched group 240 example, wherein male 170 example, women 70 example, 30 ~ 62 years old age, 55 years old mean age, the course of disease 1 year ~ 2 years, average 1.5 years.
The course of disease, the degrees of symptoms of two groups of cases are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group patient takes this Chinese medicine preparation, oral, every day 3 times, within 1 hour after meal, takes, and the morning, noon and afternoon, respectively once each 2, every sheet 30mg 20 days was a course for the treatment of, usual recovery from illness 1 ~ 4 course for the treatment of, and severe patient is followed the doctor's advice the meal with wine amount of adding.
Matched group takes gout relaxing tablet, oral, one time 2 ~ 4,3 times on the one, one after each meal.
3, efficacy determination:
(1) cure: the transference cures such as arthralgia, skin urtication, hyperuricemia; Joint recovers normal, and health is fully recovered.
(2) effective: above-mentioned symptom is alleviated to some extent, joint recovers normal, and health is fully recovered.
(3) invalid: disease is unchanged.
4, result:
Take in the treatment group of medicine of the present invention, cure 193 examples, effective 39 examples, invalid 8 examples, cure rate 80.4%, total effective rate 96.7%.
105 examples are cured, effective 85 examples, invalid 50 examples, cure rate 43.8%, total effective rate 79.2% in matched group.
Above result display, treatment group cure rate and total effective rate are apparently higher than matched group.
Model case is illustrated:
1, Xu's ××, man, 34 years old, mechanic, Shandong Zibo people.Patient is without obvious sign sensation general malaise, joint sting, and the late into the night wakes up with a start because of leg arthralgia, and pain Progressive symmetric erythrokeratodermia aggravates, and is difficult to stand.Then my institute checks, is diagnosed as gout.After taking 1 course for the treatment of of Chinese medicine preparation of the present invention, symptom is obviously alleviated, and continues to take 2 courses for the treatment of, and clinical symptoms all disappears.Follow up a case by regular visits to and do not recur so far.
2, ×× is become, man, 42 years old, private owner, people from Xuzhou, Anhui.Patient suffers from gout, and all getting involved in the joints such as ankle, knee joint, wrist and elbow, has inflammation, simultaneously with General Symptomies such as generating heat, have a headache, feel sick.Patient's numeration of leukocyte raises on inspection, and erythrocyte sedimentation rate speeds.After taking 2 courses for the treatment of of Chinese medicine preparation of the present invention, rehabilitation gradually, symptom is obviously alleviated, and continues to take 2 courses for the treatment of, above transference cure.Follow up a case by regular visits to and do not recur so far.
3, ×× is opened, female, 49 years old, builder, Lishui of Zhejiang people.The outbreak of patient's gout continues spontaneous remission in 4 weeks, pays no attention to.Recur after 8 months, after all the more more frequently, joint and surrounding tissue is red, swollen, hot, bitterly and function limitation, very painful.After people recommends to take 3 courses for the treatment of of Chinese medicine preparation of the present invention, symptom is clearly better, and after continuing to take 2 courses for the treatment of, above transference cure, gets well, not recurrence.
4, Yuan's ××, man, 53 years old, peasant, Yangquan Shanxi people.The yellow-white vegetation not of uniform size of the position protuberances such as patient's heel string and patella synovial bursa, skin surface is belittled, and discharges white powder thing, arthralgia, tenderness after ulceration.Take 2 courses for the treatment of of Chinese medicine preparation of the present invention, symptom is obviously alleviated, and after continuing to take 2 courses for the treatment of, transference cure, follows up a case by regular visits to not recurrence.
5, king's ××, female, 57 years old, unemployed, people from Yingkou, Liaoning.Patient suffers from gout, and pain, in tearing sample, is difficult to stand, and finger, wrist and ancon are all got involved, joint and surrounding tissue redness.Once took multi-medicament, and failed to cure.After taking 2 courses for the treatment of of Chinese medicine preparation of the present invention, above symptom takes a turn for the better, and after continuing to take 2 courses for the treatment of, above transference cure, physical recovery is healthy, follows up a case by regular visits to and does not recur so far.
6, Guo's ××, female, 61 years old, peasant, zhuzhou,hunan people.Patient started brothers joint before half a year and occurs edema burning pain phenomenon, and night is often waken up bitterly, and especially cold day more very, and be gout through hospital diagnosis, once took probenecid sheet, symptom is alleviated to some extent but recurred again after drug withdrawal.After people recommends to take 2 courses for the treatment of of Chinese medicine preparation of the present invention, symptom takes a turn for the better, and after then taking 3 courses for the treatment of, physical recovery is normal.Follow up a case by regular visits to and do not recur so far.

Claims (5)

1. be used for the treatment of a Chinese medicine preparation for gout, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Rhizoma Smilacis Chinensis 60 ~ 90 portions of Juniperus rigida Sieb.et Zucc. 57 ~ 87 portions of Herba Poae Sphondylodiss 55 ~ 85 parts of Radix campsis 51 ~ 81 parts
Sucus Betulae platyphyllae 50 ~ 80 parts of Radix Angelicae Pubescentiss 45 ~ 75 parts of Fructus Tonnae Sinensis 42 ~ 72 Fen Herba Rorippae 40 ~ 70 parts
Herba Artemisiae Scopariae 36 ~ 66 parts of Herba Murdanniae Triquetraes 35 ~ 65 parts of Radix osterici citriodori (Radix Angelicae Citriodorae)s 33 ~ 63 parts of Caulis aristolochiae moupinensis 31 ~ 61 parts
Herba Ranunculi Japonici 30 ~ 60 parts of Herba Asaris 26 ~ 56 parts of Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 25 ~ 55 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s 20 ~ 50 parts.
2. be used for the treatment of a Chinese medicine preparation for gout, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Rhizoma Smilacis Chinensis 83 portions of Juniperus rigida Sieb.et Zucc. 80 portions of Herba Poae Sphondylodiss 78 parts of Radix campsis 74 parts
Sucus Betulae platyphyllae 73 parts of Radix Angelicae Pubescentiss 68 parts of Fructus Tonnae Sinensis 66 Fen Herba Rorippae 64 parts
Herba Artemisiae Scopariae 62 parts of Herba Murdanniae Triquetraes 58 parts of Radix osterici citriodori (Radix Angelicae Citriodorae)s 56 parts of Caulis aristolochiae moupinensis 54 parts
Herba Ranunculi Japonici 53 parts of Herba Asaris 49 parts of Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 48 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s 43 parts.
3. be used for the treatment of a Chinese medicine preparation for gout, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Rhizoma Smilacis Chinensis 76 portions of Juniperus rigida Sieb.et Zucc. 73 portions of Herba Poae Sphondylodiss 71 parts of Radix campsis 69 parts
Sucus Betulae platyphyllae 66 parts of Radix Angelicae Pubescentiss 61 parts of Fructus Tonnae Sinensis 59 Fen Herba Rorippae 56 parts
Herba Artemisiae Scopariae 55 parts of Herba Murdanniae Triquetraes 51 parts of Radix osterici citriodori (Radix Angelicae Citriodorae)s 49 parts of Caulis aristolochiae moupinensis 45 parts
Herba Ranunculi Japonici 46 parts of Herba Asaris 42 parts of Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 41 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s 36 parts.
4. be used for the treatment of a Chinese medicine preparation for gout, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Rhizoma Smilacis Chinensis 68 portions of Juniperus rigida Sieb.et Zucc. 64 portions of Herba Poae Sphondylodiss 63 parts of Radix campsis 62 parts
Sucus Betulae platyphyllae 58 parts of Radix Angelicae Pubescentiss 53 parts of Fructus Tonnae Sinensis 50 Fen Herba Rorippae 49 parts
Herba Artemisiae Scopariae 44 parts of Herba Murdanniae Triquetraes 46 parts of Radix osterici citriodori (Radix Angelicae Citriodorae)s 42 parts of Caulis aristolochiae moupinensis 39 parts
Herba Ranunculi Japonici 37 parts of Herba Asaris 34 parts of Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 33 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s 28 parts.
5. the preparation method being used for the treatment of the Chinese medicine preparation of gout as described in any one of Claims 1 to 4, is characterized in that: comprise following processing step:
(1) Rhizoma Smilacis Chinensis, Radix campsis, Radix Angelicae Pubescentis, Radix osterici citriodori (Radix Angelicae Citriodorae) and Caulis aristolochiae moupinensis are removed impurity, clear water is unrestrained to be washed, and run through, take out section, Exposure to Sunlight is dried, and is placed in mortar and grinds into powder, must be 120 object fine powders, for subsequent use;
(2) Juniperus rigida Sieb.et Zucc., Fructus Tonnae Sinensis, Herba Artemisiae Scopariae, Herba Ranunculi Japonici and Folium eucalypti globueli (Eucalyptus globulus Labill.) are removed impurity, clean, put into container, add 5 times amount distilled water, decoct 2 hours, extract decoction liquor; Add 3 ~ 4 times amount distilled water again, decoct 1.5 hours, extract decoction liquor, finally merge the decoction liquor extracted for 2 times, filter, obtain filtrate, then add wherein by Sucus Betulae platyphyllae, being condensed into relative density at 60 DEG C is the thick paste of 1.10 ~ 1.13, for subsequent use;
(3) Herba Poae Sphondylodis, Herba Murdanniae Triquetrae and Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) are removed impurity, clean, be placed in pot and fry to tack-free, taking-up is dried, and is placed in mortar and grinds into powder, must be 140 object fine powders, for subsequent use;
(4) Herba Rorippae and Herba Asari are removed impurity, clean, cutting, sun dehydration, is placed in mortar and grinds into powder, must be 160 object fine powders, for subsequent use;
(5) make tablet after being mixed with the thick paste of step (2) gained by the fine powder of step (1), step (3), step (4) gained, be the described Chinese medicine preparation being used for the treatment of gout.
CN201511004699.XA 2015-12-29 2015-12-29 Traditional Chinese medicine preparation for treating gout and preparation method thereof Pending CN105435018A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201511004699.XA CN105435018A (en) 2015-12-29 2015-12-29 Traditional Chinese medicine preparation for treating gout and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201511004699.XA CN105435018A (en) 2015-12-29 2015-12-29 Traditional Chinese medicine preparation for treating gout and preparation method thereof

Publications (1)

Publication Number Publication Date
CN105435018A true CN105435018A (en) 2016-03-30

Family

ID=55545943

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201511004699.XA Pending CN105435018A (en) 2015-12-29 2015-12-29 Traditional Chinese medicine preparation for treating gout and preparation method thereof

Country Status (1)

Country Link
CN (1) CN105435018A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110123916A (en) * 2019-04-18 2019-08-16 余焱 A kind of exterior-applied plant essence, preparation method and application for treating urarthritis

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1397322A (en) * 2002-04-14 2003-02-19 郑子新 Chinese medicine for treating gout and process for preparing its instant particles
CN1628768A (en) * 2004-08-26 2005-06-22 成都中汇制药有限公司 Medicine for treating gout affection and its symptoms

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1397322A (en) * 2002-04-14 2003-02-19 郑子新 Chinese medicine for treating gout and process for preparing its instant particles
CN1628768A (en) * 2004-08-26 2005-06-22 成都中汇制药有限公司 Medicine for treating gout affection and its symptoms

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110123916A (en) * 2019-04-18 2019-08-16 余焱 A kind of exterior-applied plant essence, preparation method and application for treating urarthritis

Similar Documents

Publication Publication Date Title
CN102178800A (en) Chinese medicine composition for treating rheumatoid arthritis and preparation method thereof
CN105616759A (en) Traditional Chinese medicine composition for treating urticaria
CN104173696A (en) Dressing used for postoperative nursing of appendicitis and preparation method of dressing
CN102526459B (en) Traditional Chinese medicine composition for treating nasosinusitis and preparation method thereof
CN101745047A (en) Chinese medicinal composition for treating gout disease and preparation method thereof
CN108295128B (en) Traditional Chinese medicine compound preparation for treating rheumatoid arthritis and preparation method thereof
CN104225399A (en) Traditional Chinese medicine for treating pulmonary tuberculosis
CN105435018A (en) Traditional Chinese medicine preparation for treating gout and preparation method thereof
CN103446400B (en) Traditional Chinese medicine preparation for treating asthma
CN104623217A (en) Traditional Chinese medicine preparation for treating asthma and preparation method thereof
CN104324280A (en) Traditional Chinese medicine composition for treating nasopharynx cancer and preparation method of traditional Chinese medicine composition
CN103705712B (en) One treats osteoporotic Chinese medicine preparation and preparation method
CN103041362A (en) Drug for treating rheumatism and rheumatoid and preparation method thereof
CN103127258A (en) Traditional Chinese medicine for treating rheumatic arthritis
CN103191345B (en) Postoperative drug for chronic peptic ulcer and esophagitis syndrome
CN102406913A (en) Chinese medicinal composition for treating melancholia
CN102406906A (en) Traditional Chinese medicine composition for treating acute hepatitis B
CN105853749A (en) Pharmaceutical preparation for treating chronic pneumonia and preparing method
CN105902670A (en) Medicine used for traumatic hairline fracture and preparation method
CN105343698A (en) Traditional Chinese medicine preparation for treating infective endocarditis and preparation method
CN105125964A (en) Traditional Chinese medicine preparation for treating pelvic peritonitis and preparation method thereof
CN105055814A (en) Traditional Chinese medicine composition for treating gout
CN103191344B (en) Method for preparing postoperative drug for chronic peptic ulcer and esophagitis syndrome
CN103877397A (en) Medicine for treating radiation-induced pulmonary injury and preparation method thereof
CN103877304A (en) Drug for treating gall-stone and preparation method thereof

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20160330