CN102641430B - Traditional Chinese medicine decoction for treating diabetic nephropathy (DN) - Google Patents
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Abstract
The invention discloses traditional Chinese medicine decoction for treating diabetic nephropathy (DN). In the view of traditional Chinese medicine, the pathogenesis of the DN mainly relates to lungs, spleens, kidneys and other viscera; and after the course of disease lasts for a long time, the lung and spleen are damaged, and then the disease spreads to the kidney after a long time, so that the deficiency and malfunction of the kidney are caused, and turbidity is accumulated to cause toxicity and then invades into collaterals to cause blood stasis which then blocks the collaterals, thereby causing the DN. Therefore, according to the symptomatic treatment in traditional Chinese medicine science, the decoction is prepared in a manufacturing laboratory in a hospital from the following selected traditional Chinese medicines, such as fructus psoraleae, fructus lycii, semen euryales, prepared rehmannia root, fructus corni, raw glycyrrhiza, semen cuscutae, salvia miltiorrhiza, spicate clerodendranthus herb, herba dendrobii and atractylodes macrocephala, with the functions of invigorating the circulation of blood, alleviating the turbidity and tonifying the kidney. Clinical tests prove that the total effective rate of the decoction reaches 92.86% and is obviously higher than that of a control group, the 24h urine protein and ALB (albumin) of a treatment group are obviously reduced after treatment compared with those before treatment, the after-treatment 24h urine protein of the treatment group is reduced obviously compared with that of the control group, and the urine ALB is reduced obviously after treatment compared with that before the treatment, therefore, the traditional Chinese medicine decoction is worthy of clinical promotion and application.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine decoction for the treatment of diabetic nephropathy.
Background technology
Diabetics forms huge colony in China, prolongation along with the diabetes state of an illness, the performance of suffering from a deficiency of the kidney all appears in a lot of diabeticss, and diabetic nephropathy (DN) becomes one of diabetes severe complication, it can cause the glomerule infringement, final clinical manifestation is that the urinaryalbumin discharge increases, and albuminuria can be accelerated the renal damage process.
The medication treatment of diabetic nephropathy is very crucial, but if inappropriate medication is easy to cause the medicine renal damage.The medicine renal damage refers to the disease by the various kidney damages of drug-induced, and kidney is the vitals of the thing metabolism of medicine renal damage and drainage, mainly shows as nephrotoxicity and anaphylaxis.So when the treatment diabetic nephropathy, improve the understanding to dealed with medicine went, to reduce the incidence rate of medicine renal damage.Chinese herbal medicine is little with its toxicity, side effect is little, and the clinical diabetic nephropathy that is used for the treatment of can effectively alleviate medicine to the infringement of kidney.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine decoction for the treatment of diabetic nephropathy.Chinese medicine thinks, it is dirty that the DN pathogenesis relates generally to lung spleen kidney etc., the course of disease with the passing of time, the lung spleen is impaired, for a long time sick and kidney, the dysfunction of the kidney in storing essence of suffering from a deficiency of the kidney, precise and tiny solid; The cohesion of sick turbid pathogen for a long time, the turbid poison that gathers into, turbidity is gone into network, stagnation of blood stasis, it is real to belong to the deficiency in origin table, the network of suffering from a deficiency of the kidney resistance phlegm-turbidity and blood stasis knot, the state of an illness is very grave day by day.Thereby should treat in the stage based on the activating blood circulation to eliminate turbid the kidney invigorating.
The objective of the invention is to be achieved through the following technical solutions, the Chinese medicine decoction of this treatment diabetic nephropathy is made by following parts by weight of Chinese traditional medicine: Fructus Psoraleae 8-10 part, Fructus Lycii 7-9 part, Semen Euryales 7-9 part, Radix Rehmanniae Preparata 12-13 part, Fructus Corni 7-10 part, Radix Glycyrrhizae 5-7 part, Semen Cuscutae 9-12 part, Radix Salviae Miltiorrhizae 10-12 part, Herba clerodendranthi spicati 10-13 part, Herba Dendrobii 8-10 part, Rhizoma Atractylodis Macrocephalae 7-9 part.
Preferably, the Chinese medicine decoction of this treatment diabetic nephropathy is made by following parts by weight of Chinese traditional medicine: 9 parts of Fructus Psoraleaes, 8 parts of Fructus Lycii, 8 parts of Semen Euryaless, 11 parts of Radix Rehmanniae Preparata, 9 parts of Fructus Corni, 6 parts of Radix Glycyrrhizae, 11 parts of Semen Cuscutae, 11 parts of Radix Salviae Miltiorrhizaes, 12 parts of Herba clerodendranthi spicati, 9 parts of Herba Dendrobiis, 8 parts of the Rhizoma Atractylodis Macrocephalaes.
To add medicine to being decocted in water for oral dose 1 dose of every day.7 days was 1 course for the treatment of, took effect about 3 courses for the treatment of.
In the side: Fructus Psoraleae: return kidney channel, reinforcing the kidney and supporting YANG, controlling nocturnal emission with astringent drugs reducing urination, warm spleen antidiarrheal, helping inspiration to relieve asthma;
Fructus Lycii: the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, blood-enriching tranquillizing, promoting the production of body fluid to quench thirst, nourishing the lung to arrest cough;
Semen Euryales: stomach, lung, kidney, supplementing the kidney to control the nocturnal, invigorating the spleen to arrest diarrhea, eliminating dampness and arresting leucorrhea;
Radix Rehmanniae Preparata: return liver, kidney channel, the YIN nourishing of enriching blood, beneficial essence is filled out marrow;
Fructus Corni: liver and kidney tonifying, essence astringing and desertion stemming is used for vertigo and tinnitus, soreness of waist and knee joint, interior-heat is quenched one's thirst;
Radix Glycyrrhizae: GUIXIN, spleen, lung, stomach warp, the spleen reinforcing stomach function regulating, QI invigorating is multiple, weakness of the spleen and stomach; Semen Cuscutae: go into liver, kidney channel, invigorating the liver and kidney, beneficial marrow is controlled soreness of waist and knee joint, and seminal emission is quenched one's thirst;
Radix Salviae Miltiorrhizae: GUIXIN, pericardium, Liver Channel, blood circulation promoting and blood stasis dispelling, nourishing blood to tranquillize the mind, the effect of removing heat from blood detumescence.
Herba clerodendranthi spicati: clearing heat and expelling damp, calculus diuretic, treatment acute and chronic nephritis;
Herba Dendrobii: return through stomach lung, kidney, replenishing YIN and removing heat, reinforcing stomach reg fluid;
The Rhizoma Atractylodis Macrocephalae: return spleen, stomach warp, invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, insufficiency of the spleen lack of appetite, edema.
Clinical data
1, physical data is divided into two groups at random with all selected patient's 220 examples.Because going on business, leave under order, move, merge acute complications and adverse effect and therapy discontinued is observed 20 examples in the therapeutic process, wherein 16 examples are organized in treatment, matched group 4 examples are rejected from treatment group and matched group case, final complete effective case 200 examples, 140 examples are organized in treatment, male 64 examples, women 76 examples; 35～76 years old age, average 55.5 years old; Course of disease 4-18, average 9 years.Matched group 60 examples, male 22 examples, women 38 examples; 36～77 years old age, average 56.5 years old; The course of disease 3～17 years, average 7.5 years.Credit is analysed by statistics, and there are no significant (P＞0.05) for difference on two groups of sexes, age, the course of disease, has comparability.
2, Therapeutic Method: the treatment group is taken Chinese medicine decoction of the present invention, and 1 dose of every day, 7 days was 1 course for the treatment of; Matched group is taken sulphanylureas, biguanides, glycosidase inhibitor, thiazolidinedione, methyl methylamine benzoic acid derivative and insulin injection, and 7 days is a course for the treatment of, two groups all treat 3 courses for the treatment of after, observe the curative effect.
3, diagnostic criteria: work out with reference to Ministry of Public Health " new Chinese medicine clinical research guideline ".1. produce effects: the routine urianlysis urine protein reduces by 2 "+", or the twenty-four-hour urine protein quantification reduces 〉=40%, and renal function is normal.2. effective: the routine urianlysis urine protein reduces by 1 "+", or the twenty-four-hour urine protein quantification reduces＜40%, the normal or improvement of renal function.3. invalid: clinical symptoms or above-mentioned lab testing all do not have improvement or the person of increasing the weight of.
4, therapeutic outcome
(1) two group of curative effect compares: the statistics curative effect sees Table 1. after three courses for the treatment of
Table 1 liang group curative effect is [n (%) relatively
Compare * P＜0.05 with matched group
(2) 24h urine protein quantitation, Ccr and ALB compare before and after the treatment, and each phase 24h urine protein is organized in treatment, ALB controls preceding obviously reduce (P all＜0.05) after controlling, more obviously minimizing (P＜0.05) of 24h urine protein after controlling with matched group; Urine ALB treatment back is than preceding significantly descend (P＜0.05) for the treatment of.The results are shown in Table 2.
Table 2 liang group 24 urine protein quantitation result (x
-± s, mg)
Annotate: 1. compare P＜0.05 with matched group
The specific embodiment
Embodiment one: take by weighing Fructus Psoraleae 9g, Fructus Lycii 8g, Semen Euryales 8g, Radix Rehmanniae Preparata 11g, Fructus Corni 9g, Radix Glycyrrhizae 6g, Semen Cuscutae 11g, Radix Salviae Miltiorrhizae 11g, Herba clerodendranthi spicati 12g, Herba Dendrobii 9g, Rhizoma Atractylodis Macrocephalae 8g.To add medicine to being decocted in water for oral dose, 1 dose of every day, 7 days was 1 course for the treatment of, serve on 3 courses for the treatment of.
Embodiment two: take by weighing Fructus Psoraleae 8g, Fructus Lycii 7g, Semen Euryales 7g, Radix Rehmanniae Preparata 12g, Fructus Corni 7g, Radix Glycyrrhizae 5g, Semen Cuscutae 9g, Radix Salviae Miltiorrhizae 10g, Herba clerodendranthi spicati 10g, Herba Dendrobii 8g, Rhizoma Atractylodis Macrocephalae 7g.To add medicine to being decocted in water for oral dose, 1 dose of every day, 7 days was 1 course for the treatment of, serve on 3 courses for the treatment of.
Embodiment three: take by weighing Fructus Psoraleae 10g, Fructus Lycii 9g, Semen Euryales 9g, Radix Rehmanniae Preparata 13g, Fructus Corni 10g, Radix Glycyrrhizae 7g, Semen Cuscutae 12g, Radix Salviae Miltiorrhizae 12g, Herba clerodendranthi spicati 13g, Herba Dendrobii 10g, Rhizoma Atractylodis Macrocephalae 9g.To add medicine to being decocted in water for oral dose, 1 dose of every day, 7 days was 1 course for the treatment of, serve on 3 courses for the treatment of.
Claims (1)
1. Chinese medicine decoction for the treatment of diabetic nephropathy is characterized in that this Chinese medicine decoction made by the Chinese medicine of following weight: Fructus Psoraleae 8g, Fructus Lycii 7g, Semen Euryales 7g, Radix Rehmanniae Preparata 12g, Fructus Corni 7g, Radix Glycyrrhizae 5g, Semen Cuscutae 9g, Radix Salviae Miltiorrhizae 10g, Herba clerodendranthi spicati 10g, Herba Dendrobii 8g, Rhizoma Atractylodis Macrocephalae 7g.
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| CN103272079B (en) * | 2013-05-29 | 2015-10-21 | 宁夏医科大学 | A kind of drug compound and application thereof for the treatment of diabetic nephropathy |
| CN104971290A (en) * | 2015-06-23 | 2015-10-14 | 济南邦文医药科技有限公司 | Traditional Chinese medicine for treating middle and advanced diabetic nephropathy amalgamative nausea and vomiting |
| CN104888082A (en) * | 2015-06-23 | 2015-09-09 | 济南邦文医药科技有限公司 | Traditional Chinese medicine for treatment of middle-late diabetic nephropathy merged anemia |
| CN104888083A (en) * | 2015-06-23 | 2015-09-09 | 济南邦文医药科技有限公司 | Traditional Chinese medicine for treatment of middle-late diabetic nephropathy merged heart palpitations |
| CN111529645B (en) * | 2020-04-16 | 2022-03-15 | 上海市嘉定区中医医院 | Medicine for treating kidney deficiency and collateral stasis type diabetic nephropathy in stage IV |
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| CN102048958B (en) * | 2011-01-13 | 2012-01-25 | 湖南龙石山铁皮石斛基地有限公司 | Compound dendrobium candidum hypoglycemic composition and preparation method thereof |
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