CN104971290A - Traditional Chinese medicine for treating middle and advanced diabetic nephropathy amalgamative nausea and vomiting - Google Patents

Abstract

The invention belongs to the technical field of medicines, and concretely relates to a traditional Chinese medicine for treating middle and advanced diabetic nephropathy amalgamative nausea and vomiting. The traditional Chinese medicine is prepared from, by weight, 8-16 parts of Malaytea Scurfpea Fruit, 8-16 parts of sharpleaf galangal fruit, 8-16 parts of semen cuscutae, 8-16 parts of Achyranthes bidentata, 8-16 parts of Salvia miltiorrhiza, 8-16 parts of Folium Sennae, 4-8 parts of Semen Pharbitidis, 5-13 parts of Fructus Citri Sarcodactylis, 8-16 parts of Prsimmon Calyx, 8-16 parts of sword bean, 4-8 parts of Syzygium aromaticum and 4-8 parts of licorice root. The traditional Chinese medicine can improve the kidney functions of patients, and obviously mitigates nausea and vomiting symptoms.

Description

A kind of Chinese medicine for the treatment of middle and advanced stage diabetic nephropathy and merging nausea and vomiting

Technical field

The invention belongs to medical art, be specifically related to a kind of Chinese medicine for the treatment of middle and advanced stage diabetic nephropathy and merging nausea and vomiting.

Background technology

Diabetic nephropathy (Diabetic nephrpathy, DN) be one of common complication of diabetes, also be cause diabetics main causes of death, it is reported that the sickness rate of DN is about 40 ~ 50% in type 1 diabetes, in type 2 diabetes mellitus, DN incidence rate is about 20%.Diabetic nephropathy is the major reason causing End-stage renal disease (ESRD), heavy financial burden is brought to patient home and society, so far there is no effectively preventing measure, therefore find control the effective medicine of DN and method oneself become diabetes circle research important topic.Middle and advanced stage diabetic nephropathy often merges nausea and vomiting, and this nausea and vomiting uses common nausea and vomiting medicine, and often curative effect is very poor, or increases the weight of diabetic nephropathy, therefore, needs to find a kind of medicine that not only may be used for diabetic nephropathy but also can improve nausea and vomiting.

Summary of the invention

Technical problem to be solved by this invention avoids the weak point existing for above-mentioned prior art, a kind of Chinese medicine for the treatment of middle and advanced stage diabetic nephropathy and merging nausea and vomiting is provided, this Chinese medicine while improving kidneys of patients function, can obviously alleviate nausea and vomiting symptom.

The present invention is achieved through the following technical solutions:

Treat the Chinese medicine that middle and advanced stage diabetic nephropathy merges nausea and vomiting, be made up of the raw material of Chinese medicine medicine of following weight portion:

Fructus Psoraleae 8-16 part, Fructus Alpiniae Oxyphyllae 8-16 part, Semen Cuscutae 8-16 part, Radix Achyranthis Bidentatae 8-16 part, Radix Salviae Miltiorrhizae 8-16 part, Folium Sennae 8-16 part, Semen Pharbitidis 4-8 part, Fructus Citri Sarcodactylis 5-13 part, Calyx Kaki 8-16 part, Semen Canavaliae 8-16 part, Flos Caryophylli 4-8 part, Radix Glycyrrhizae 4-8 part.

Preferably, above-mentioned treatment middle and advanced stage diabetic nephropathy merges the Chinese medicine of nausea and vomiting, is made up of the raw material of Chinese medicine medicine of following weight portion:

Fructus Psoraleae 10-14 part, Fructus Alpiniae Oxyphyllae 10-14 part, Semen Cuscutae 10-14 part, Radix Achyranthis Bidentatae 10-14 part, Radix Salviae Miltiorrhizae 10-14 part, Folium Sennae 10-14 part, Semen Pharbitidis 5-7 part, Fructus Citri Sarcodactylis 7-11 part, Calyx Kaki 10-14 part, Semen Canavaliae 10-14 part, Flos Caryophylli 5-7 part, Radix Glycyrrhizae 5-7 part.

Preferred, above-mentioned treatment middle and advanced stage diabetic nephropathy merges the Chinese medicine of nausea and vomiting, is made up of the raw material of Chinese medicine medicine of following weight portion:

Fructus Psoraleae 12 parts, Fructus Alpiniae Oxyphyllae 12 parts, Semen Cuscutae 12 parts, Radix Achyranthis Bidentatae 12 parts, Radix Salviae Miltiorrhizae 12 parts, Folium Sennae 12 parts, Semen Pharbitidis 6 parts, Fructus Citri Sarcodactylis 9 parts, Calyx Kaki 12 parts, Semen Canavaliae 12 parts, Flos Caryophylli 6 parts, 6 parts, Radix Glycyrrhizae.

The ratio of above weight proportion is through that science screening obtains, and for especial patient, as serious symptom or mild, fat or modest patient, can the proportioning of amount of corresponding adjustment composition, and increase or reduce being no more than 100%, drug effect is substantially constant.

The weight portion of said medicine, if in units of g, the normally consumption of 1 dose.

The indication of Chinese medicine of the present invention: be used for the treatment of middle and advanced stage diabetic nephropathy and merge nausea and vomiting.

The taboo item of Chinese medicine of the present invention: the fasting for the treatment of period in a medicine is greasy, raw and cold, the smelling of fish or mutton, irritant and stodgy food.

The pathogenic characteristic of diabetic nephropathy is: with Liver and kidney deficiency of both QI and YIN, and the kidney network stasis of blood is stagnant for falling ill originally, and basic pathology link is kidney network stasis blocking, kidney network stasis.At the beginning of morbidity, the disease being located in the liver kidney, deficiency of both QI and YIN, the kidney network stasis of blood is stagnant.The main water of kidney, department opens entire, diabetes with the passing of time, damage of kidney-YIN, cloudy loss gas, and it is deficient to cause kidney qi, astringency inducing is had no right, and opens entire mistake department, frequent micturition frequent micturition, turbid urine and sweet; The hepatic and renal YIN deficiency, hyperactivity of YANG due to deficiency of YIN, dizzy, tinnitus, slight Hypertension.The course of disease is delayed, and deficiency of YIN affecting YANG, spleen is suffered from a deficiency of the kidney and declined, kidney network stasis blocking.Spleen is suffered from a deficiency of the kidney and is declined, kidney network stasis blocking, and water liquid dysbolismus then water storage of wetting is stayed, and overflow skin, then face podedema, very then hydrothorax ascites; Yang deficiency can not warm four end, then aversion to cold and cold limbs.Pathological changes late period, kidney network stasis, kidney body labor declines, and kidney mistake department, stop in turbid poison, the five internal organs are impaired, and negative and positive of qi and blood is decayed.Kidney yang decays, and water is wet to spread unchecked, and stop in turbid poison, deteriorated case comes in great numbers.General on turbid poison, stomach-QI being unable to descend normally, then there is the symptoms of digestive tract such as nausea and vomiting in adverse rising of stomach-QI;

Therefore, the symptoms of digestive tract such as nausea and vomiting are very common in middle and advanced stage diabetic nephropathy, tonify Qi of the kidney, eliminating blood stasis and smoothing collaterals, toxin expelling let out the ruling by law of turbid, regulating the flow of Qi and the middle Jiao, stopping nausea and vomiting by lowering the adverse flow of QI and treat diabetic nephropathy middle and advanced stage and merge nausea and vomiting.

Become ulcer; Light red tongue, tongue in vain greasy, deep-thready pulse are resembling of the cold Sheng of yang deficiency.

Chinese prescription mechanism of the present invention is as follows:

Monarch drug: Fructus Psoraleae, Fructus Alpiniae Oxyphyllae, Semen Cuscutae merit are monarch drug with tonifying the kidney to consolidate the essence, and kidney qi is filled, water liquid gasification discrepancy officials, water turbid damp poison is from going.

Ministerial drug: Fructus Citri Sarcodactylis merit is with regulating the flow of Qi and the middle Jiao; Calyx Kaki, Semen Canavaliae merit with stopping nausea and vomiting by lowering the adverse flow of QI, warming the kidney to activate YANG, Flos Caryophylli merit with warming middle-JIAO to send down the adverse QI, warming the kidney to activate YANG, Fructus Crataegi merit with promoting digestion and removing stagnation, promote appetite; Five medicines share treatment stomach-QI being unable to descend normally, the singultus that adverse rising of stomach-QI causes, nausea and vomiting and inappetence.

Adjuvant drug: Folium Sennae merit is to rush down lower intestinal stasis relieving, and toxin expelling is let out turbid, removes pathological factor; Semen Pharbitidis merit is with removing water retention by purgation, and water is wet to be gone, and face podedema, hydrothorax ascites are from disappearing; Radix Achyranthis Bidentatae, Radix Salviae Miltiorrhizae merit are with promoting blood circulation to remove obstruction in the collateral, and the kidney network stasis of blood of dispelling is stagnant, improves Renal microcirculation.

Make medicine: Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.

The all medicines of we's reasonable recipe share, play altogether tonify Qi of the kidney, eliminating blood stasis and smoothing collaterals, toxin expelling let out turbid, regulating the flow of Qi and the middle Jiao, stopping nausea and vomiting by lowering the adverse flow of QI effect, the middle and advanced stage diabetic nephropathy that links closely merges the etiology and pathogenesis of nausea and vomiting, while improving kidneys of patients function, obviously alleviates nausea and vomiting symptom.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.

Embodiment 1

Treat the Chinese medicine that middle and advanced stage diabetic nephropathy merges nausea and vomiting, each crude drug weight proportion is as follows:

Fructus Psoraleae 12g, Fructus Alpiniae Oxyphyllae 12g, Semen Cuscutae 12g, Radix Achyranthis Bidentatae 12g, Radix Salviae Miltiorrhizae 12g, Folium Sennae 12g, Semen Pharbitidis 6g, Fructus Citri Sarcodactylis 9g, Calyx Kaki 12g, Semen Canavaliae 12g, Flos Caryophylli 6g, Radix Glycyrrhizae 6g.

Embodiment 2

Treat the Chinese medicine that middle and advanced stage diabetic nephropathy merges nausea and vomiting, each crude drug weight proportion is as follows:

Fructus Psoraleae 10g, Fructus Alpiniae Oxyphyllae 14g, Semen Cuscutae 10g, Radix Achyranthis Bidentatae 14g, Radix Salviae Miltiorrhizae 10g, Folium Sennae 14g, Semen Pharbitidis 5g, Fructus Citri Sarcodactylis 11g, Calyx Kaki 10g, Semen Canavaliae 14g, Flos Caryophylli 5g, Radix Glycyrrhizae 7g.

Embodiment 3

Treat the Chinese medicine that middle and advanced stage diabetic nephropathy merges nausea and vomiting, each crude drug weight proportion is as follows:

Fructus Psoraleae 14g, Fructus Alpiniae Oxyphyllae 10g, Semen Cuscutae 14g, Radix Achyranthis Bidentatae 10g, Radix Salviae Miltiorrhizae 14g, Folium Sennae 10g, Semen Pharbitidis 7g, Fructus Citri Sarcodactylis 7g, Calyx Kaki 14g, Semen Canavaliae 10g, Flos Caryophylli 7g, Radix Glycyrrhizae 5g.

Embodiment 4

Treat the Chinese medicine that middle and advanced stage diabetic nephropathy merges nausea and vomiting, each crude drug weight proportion is as follows:

Fructus Psoraleae 8g, Fructus Alpiniae Oxyphyllae 16g, Semen Cuscutae 8g, Radix Achyranthis Bidentatae 16g, Radix Salviae Miltiorrhizae 8g, Folium Sennae 16g, Semen Pharbitidis 4g, Fructus Citri Sarcodactylis 13g, Calyx Kaki 8g, Semen Canavaliae 16g, Flos Caryophylli 4g, Radix Glycyrrhizae 8g.

Embodiment 5

Treat the Chinese medicine that middle and advanced stage diabetic nephropathy merges nausea and vomiting, each crude drug weight proportion is as follows:

Fructus Psoraleae 16g, Fructus Alpiniae Oxyphyllae 8g, Semen Cuscutae 16g, Radix Achyranthis Bidentatae 8g, Radix Salviae Miltiorrhizae 16g, Folium Sennae 8g, Semen Pharbitidis 8g, Fructus Citri Sarcodactylis 5g, Calyx Kaki 16g, Semen Canavaliae 8g, Flos Caryophylli 8g, Radix Glycyrrhizae 4g.

Merge nausea and vomiting Chinese medicine to treatment middle and advanced stage diabetic nephropathy of the present invention and carried out clinical pharrnacokinetics test, Details as Follows:

1. data and method

1.1 object of study

Choose 200 routine diabetic nephropathy middles and advanced stage and merge nausea and vomiting patient.

1.1.1 diagnostic criteria

Western medicine diagnose standard:

The diagnosis of diabetic nephropathy middle and advanced stage was IV phase by Mogensen staging scale, and 133umol/L (1.5mg/dl)≤serum creatinine≤265umol/L (3mg/dl) person;

Tcm diagnosis standard:

According to the CM syndrome differentiation criterion that diabetes (diabetes) branch of Chinese Chinese medicine association formulates, card belongs to kidney qi virtual loss, turbid malicious inner stopper (possess suffer from a deficiency of the kidney, the person that stops CM syndrome differentiation criterion in the deficiency of vital energy, turbid poison be in kidney qi virtual loss, turbid poison and stop card).

1.1.2 inclusive criteria

Allly be diagnosed as diabetic renal insufficiency 133umol/L (1.5mg/dl)≤serum creatinine≤265umol/L (3mg/dl) and Chinese medical discrimination meets the person that stops card in kidney qi virtual loss, turbid poison, age is between 35 ~ 75 years old, merge the symptoms of digestive tract such as Nausea and vomiting, test case can be included in.

1.1.3 exclusion standard

(1) above-mentioned diagnostic criteria is not met.

(2) within nearly 1 month, the acute metablize confusion and the urinary system infection persons such as diabetic ketoacidosis is had.

(3) the severe primary diseases such as cardiovascular and cerebrovascular vessel, liver, kidney, immunity and hemopoietic system are associated with.

(4) age <35 year or age >75 year, psychotic, or those who are allergic to this drug.

(5) gestation or women breast-feeding their children, or prepare pregnant person.

1.1.4 standard is rejected

(1) find after on-test that experimenter does not meet case inclusive criteria.

(2) experimenter's compliance is poor, not service test medication

1.2 method

1.2.1 Therapeutic Method

Chinese herbs decoction, day potion, sooner or later sub-service 1 month is a course for the treatment of.

1.2.2. observation index

Observe the change of clinical symptoms, sign, urine protein, serum creatinine, endogenous creatinine clearance rate before and after treatment.Endogenous creatinine clearance rate computing formula:

Man: interior granulation promoting joins clearance rate (ml/min)=(140-age) x body weight (kg)/72x serum creatinine concentration (mg/dl)

Female: interior granulation promoting joins clearance rate (ml/min)=(140-age) x body weight (kg)/85x serum creatinine concentration (mg/dl)

1.2.3 the standard of curative effect evaluation

(1) efficacy on diabetic nephropathy evaluation criterion:

Cure: urine protein, serum creatinine, drop to normal range, interior granulation promoting is joined clearance rate and is recovered normal;

Effective: urine protein reduces >=40%, serum creatinine reduces >=20%, and interior granulation promoting joins clearance rate increases >=20%.

Effective: urine protein, serum creatinine decline >=10%, interior granulation promoting joins clearance rate increases >=10%, but does not reach effective standard.

Invalid: urine protein, blood flesh are joined, interior granulation promoting is joined clearance rate and all do not reached above standard.

(2) symptom of digestive tract the standard of curative effect evaluation

Cure: nausea and vomiting symptom disappears completely;

Effective: nausea and vomiting symptom is clearly better;

Effective: nausea and vomiting symptom takes a turn for the better to some extent;

Invalid: nausea and vomiting symptom is unchanged even to be increased the weight of;

2. result

Before and after 2.1 treatments, urine protein, serum creatinine, interior granulation promoting join clearance rate

	24h urine protein (mg/24h)	Serum creatinine (umol/L)	Interior granulation promoting joins clearance rate (ml/min)
				Before treatment	1.97±0.47	198.37±30.26	32.37±6.58
After treatment	0.46±0.12	102.22±22.31	56.24±7.09

2.2 efficacy on diabetic nephropathy

200 routine patients, cure 62 examples (31.0%), effective 78 examples (39.0%), effective 50 examples (25.0%), invalid 10 examples (5.0%); Cure rate 31.0%, total obvious effective rate 70.0%, total effective rate 95.0%.

2.3 nausea and vomiting symptom curative effects

200 routine patients, cure 142 examples (71.0%), effective 30 examples (15.0%), effective 20 examples (10.0%), invalid 8 examples (4.0%), cure rate 71.0%, total obvious effective rate 86.0%, total effective rate 96.0%.

Claims (3)

1. treat the Chinese medicine that middle and advanced stage diabetic nephropathy merges nausea and vomiting, be made up of the raw material of Chinese medicine medicine of following weight portion:

Fructus Psoraleae 8-16 part, Fructus Alpiniae Oxyphyllae 8-16 part, Semen Cuscutae 8-16 part, Radix Achyranthis Bidentatae 8-16 part, Radix Salviae Miltiorrhizae 8-16 part, Folium Sennae 8-16 part, Semen Pharbitidis 4-8 part, Fructus Citri Sarcodactylis 5-13 part, Calyx Kaki 8-16 part, Semen Canavaliae 8-16 part, Flos Caryophylli 4-8 part, Radix Glycyrrhizae 4-8 part.

2. treatment middle and advanced stage diabetic nephropathy according to claim 1 merges the Chinese medicine of nausea and vomiting, it is characterized in that, is made up of the raw material of Chinese medicine medicine of following weight portion:

Fructus Psoraleae 10-14 part, Fructus Alpiniae Oxyphyllae 10-14 part, Semen Cuscutae 10-14 part, Radix Achyranthis Bidentatae 10-14 part, Radix Salviae Miltiorrhizae 10-14 part, Folium Sennae 10-14 part, Semen Pharbitidis 5-7 part, Fructus Citri Sarcodactylis 7-11 part, Calyx Kaki 10-14 part, Semen Canavaliae 10-14 part, Flos Caryophylli 5-7 part, Radix Glycyrrhizae 5-7 part.

3. treatment treatment middle and advanced stage diabetic nephropathy according to claim 2 merges the Chinese medicine of nausea and vomiting, it is characterized in that, is made up of the raw material of Chinese medicine medicine of following weight portion:

Fructus Psoraleae 12 parts, Fructus Alpiniae Oxyphyllae 12 parts, Semen Cuscutae 12 parts, Radix Achyranthis Bidentatae 12 parts, Radix Salviae Miltiorrhizae 12 parts, Folium Sennae 12 parts, Semen Pharbitidis 6 parts, Fructus Citri Sarcodactylis 9 parts, Calyx Kaki 12 parts, Semen Canavaliae 12 parts, Flos Caryophylli 6 parts, 6 parts, Radix Glycyrrhizae.